Traditional Chinese medicine formula for treating intractable acute throat pain and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine formula for treating intractable acute throat pain and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. Comprising the following raw materials: 12-18 parts of radix scrophulariae, 12-18 parts of radix ophiopogonis, 12-18 parts of radix asparagi, 12-18 parts of radix platycodonis, 12-18 parts of radix achyranthis bidentatae, 12-18 parts of radix salviae miltiorrhizae, 12-18 parts of radix angelicae sinensis, 8-12 parts of peach kernels, 12-18 parts of fructus arctii, 8-12 parts of rhizoma anemarrhenae, 8-12 parts of cortex phellodendri, 4-8 parts of periostracum cicada, 6-10 parts of mint and 4-8 parts of wine-processed radix et rhizoma rhei. According to the formula, synergism is achieved through system synergism of the three components of nourishing yin, activating blood and relieving sore-throat, intractable severe throat pain (sore-throat fluid has painful feeling) can be rapidly relieved, drug resistance is avoided, throat pain can be cured within 3 days, and the blank of treatment of antibiotic ineffective pharyngalgia is filled up.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine formula for treating intractable acute throat pain and a preparation method thereof. Background Art

[0002] Throat discomfort refers to the discomfort symptoms in the throat. The cause and pathogenesis are complex and involve a wide spectrum of diseases. Not only throat diseases will cause throat discomfort, but also diseases of other systems in the body will occur. Throat discomfort mainly includes three types: throat pain, throat dryness and throat obstruction.

[0003] Sore throat is a common clinical symptom, often occurring during the cold season. Colds, tonsillitis, sinusitis, whooping cough, pharyngitis, and viral infections can all cause sore throats. Anything that irritates the throat and oral mucosa can cause sore throats, including viruses, bacterial infections, allergic reactions, dust, cigarettes, exhaust fumes, hot drinks or food. Tooth or gum infections can also sometimes affect the throat. Chronic coughs, extremely dry environments, gastroesophageal reflux, and speaking too loudly can also irritate the throat. Hoarseness is a common accompanying symptom. Sore throats can cause significant inconvenience to patients' lives, work, and communication with others.

[0004] At present, acute throat pain is routinely treated with antibiotics / antiviral drugs, but clinically, stubborn cases (pain rating ≥ 7, dysphagia) with high drug resistance, recurrent attacks, and ineffective infusion are prone to occur. Existing Chinese patent medicines (such as Liushen Pills) are mostly for common pharyngitis, and are not effective for stubborn severe pain, and contain toxic ingredients such as musk.

[0005] Therefore, there is an urgent need to develop a safe and effective Chinese medicine formula for treating intractable acute sore throat. Summary of the Invention

[0006] In view of this, the present invention provides a traditional Chinese medicine formula for treating intractable acute sore throat and a preparation method thereof. The formula achieves synergy through the systematic synergy of the three components of nourishing yin, activating blood circulation and relieving sore throat, can quickly relieve intractable severe sore throat (painful feeling when swallowing water), avoid drug resistance, and can be cured within 3 days, filling the treatment gap of sore throat that is ineffective with antibiotics.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] A traditional Chinese medicine formula for treating intractable acute sore throat, comprising the following raw materials in parts by weight:

[0009] 12-18 parts of Scrophulariaceae, 12-18 parts of Ophiopogon japonicus, 12-18 parts of Asparagus cochinchinensis, 12-18 parts of Platycodon grandiflorum, 12-18 parts of Achyranthes bidentata, 12-18 parts of Salvia miltiorrhiza, 12-18 parts of Angelica sinensis, 8-12 parts of peach kernel, 12-18 parts of Arctium lappa, 8-12 parts of Anemarrhena rhizome, 8-12 parts of Phellodendron chinense, 4-8 parts of Periostracum cicadae, 6-10 parts of mint, and 4-8 parts of wine-processed rhubarb.

[0010] The formula of the present invention adopts a triple synergistic mechanism design, specifically: the nerve analgesic layer uses mint and cicada shell to inhibit TRPV1 pain receptors and block the severe pain signals triggered by swallowing; the blood circulation and collateral dredge layer uses peach kernel, wine and salvia miltiorrhiza to reduce the concentration of substance P / bradykinin and improve mucosal microcirculation disorders; the yin-nourishing and fire-reducing layer uses Scrophularia, Anemarrhena and Phellodendron to downregulate TNF-α / IL-6 inflammatory factors and eliminate the immune storm caused by drug-resistant bacteria; at the same time, through the excessive use of mint (8g> the upper limit of the pharmacopoeia), the effect of the formula is very good. 5g), directly penetrates through the mucous membrane and produces a local anesthetic effect within 5 minutes; enhances the solubility of rhubarb anthraquinone and accelerates the absorption of blood-activating ingredients (the time for blood drug concentration to reach peak is shortened by 50%); the anthraquinone content is increased by 30% after being processed with Jiujun wine, which quickly clears the bowels and activates blood circulation; the sesquiterpenoid content of burdock seeds is ≥1.2mg / g, which strongly inhibits pharyngeal streptococci; the chitin hydrolyzate of cicada slough blocks the pain conduction pathway; through the above combination and principles, a targeted compound is obtained that can quickly end intractable pharyngeal pain and bypass the mechanism of Western medicine resistance.

[0011] Preferably, the raw materials include the following parts by weight: 15 parts of Scrophulariaceae, 15 parts of Ophiopogon japonicus, 15 parts of Asparagus cochinchinensis, 15 parts of Platycodon grandiflorum, 15 parts of Achyranthes bidentata, 15 parts of Salvia miltiorrhiza, 15 parts of Angelica sinensis, 10 parts of peach kernel, 15 parts of Burdock fruit, 10 parts of Anemarrhena asphodeloides, 10 parts of Phellodendron chinense, 6 parts of Cicada Periostracum, 8 parts of Menthol and 6 parts of wine-processed Rhubarb.

[0012] Preferably, the dosage form of the traditional Chinese medicine formula is any one of a spray, a decoction, a pill, a powder, a capsule or an external plaster.

[0013] The method for preparing the above-mentioned traditional Chinese medicine formula for treating intractable acute sore throat comprises the following specific steps:

[0014] (1) Weigh the raw materials according to the weight parts and set aside;

[0015] (2) The remaining raw materials except for the ginseng, mint and cicada slough are soaked and decocted for the first time, and then the ginseng, mint and cicada slough are added and decocted for the second time. After the decoction is completed, the filtrate is filtered to obtain a filtrate, and the filtrate is concentrated and used as a decoction or further prepared into other dosage forms.

[0016] Preferably, the soaking in step (2) is performed by adding water 10 times the weight of the remaining raw materials for 40-60 minutes.

[0017] Preferably, the first decoction in step (2) is first boiling over high heat and then decocting over low heat for 25-60 minutes.

[0018] Preferably, the second decoction in step (2) lasts for 5-30 minutes.

[0019] Preferably, step (2) is concentrated to concentrate the filtrate to a relative density of 1.1-1.15.

[0020] Preferably, the formulation of the present invention is suitable for people with a VAS score of ≥7 for throat pain, who are unresponsive to antibiotics (such as amoxicillin) and antiviral drugs (such as oseltamivir), and who have difficulty swallowing (unable to drink water); after one dose, the pain score decreases by ≥50% (water can be drunk) within 24 hours, and after three doses, the pain VAS score can be reduced to ≤1, and the area of ​​pharyngeal congestion disappears by ≥90%.

[0021] It can be seen from the above technical solution that compared with the prior art, the beneficial effects of the present invention are as follows:

[0022] The components of the present invention are synergistically compatible, specifically:

[0023] (1) The Yin-nourishing and Fire-reducing Synergistic Group used Scrophularia ningpoensis + Ophiopogon japonicus + Asparagus cochinchinensis to nourish Yin and promote fluid production, clear away heat, and the three herbs together increased fluid production (Ophiopogon japonicus polysaccharide promoted saliva secretion) and synergistically reduced inflammatory factors such as IL-6 (asparagus saponin inhibited the NF-κB pathway); Anemarrhena rhizome + Phellodendron chinense to clear away heat and fire, and relieve bone steaming. Anemarrhena rhizome saponins and Phellodendron chinense berberine synergistically downregulated the TRPV1 channel, enhancing the cooling and analgesic effects;

[0024] (2) The blood circulation promoting and collateral dredging synergistic group used Danshen + Angelica sinensis + peach kernel to promote blood circulation and remove blood stasis, improve microcirculation, and the combination of Tanshinone IIA and ferulic acid (Angelica sinensis) can upregulate VEGF expression and promote angiogenesis; Achyranthes bidentata + wine-processed rhubarb can guide blood downward, clear the bowels and relieve heat, and Achyranthes bidentata saponins enhance the intestinal peristalsis effect of rhubarb anthraquinones and reduce the side effect of constipation;

[0025] (3) The synergistic group for relieving sore throat and improving speech, using Platycodon grandiflorum + Arctium lappa + Cicada slough, can clear the lungs and relieve sore throat, and is anti-allergic. Platycodon saponins and arctigenin synergistically inhibit the release of histamine. DETAILED DESCRIPTION

[0026] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0027] Example 1

[0028] The present invention provides a method for preparing a traditional Chinese medicine formula for treating intractable acute throat pain, wherein the granules comprise the following specific steps:

[0029] (1) Weigh the following raw materials: Scrophulariae 15g, Ophiopogon 15g, Asparagus cochinchinensis 15g, Platycodon grandiflorum 15g, Achyranthes bidentata 15g, Salvia miltiorrhiza 15g, Angelica sinensis 15g, Peach kernel 10g, Arctium lappa 15g, Anemarrhena asphodeloides 10g, Phellodendron amurense 10g, Periostracum cicadae 6g, Mentha 8g, and Rhubarb wine-processed 6g;

[0030] (2) Add 10 times the weight of cold water to the remaining raw materials except for the ginseng, mint and cicada slough and soak for 40 minutes. Bring to a boil over high heat, then simmer over low heat for 25 minutes. Then add the ginseng, mint and cicada slough and continue simmering for 5 minutes. Filter the filtrate and concentrate it to 250 ml to prepare the water decoction.

[0031] Example 2

[0032] The present invention provides a method for preparing a traditional Chinese medicine formula for treating intractable acute throat pain, wherein the granules comprise the following specific steps:

[0033] (1) Weigh the following raw materials: Scrophulariae 12g, Ophiopogon 12g, Asparagus cochinchinensis 12g, Platycodon grandiflorum 12g, Achyranthes bidentata 12g, Salvia miltiorrhiza 12g, Angelica sinensis 12g, Peach kernel 8g, Arctium 12g, Anemarrhena 8g, Phellodendron amurense 8g, Periostracum Cicadae 4g, Mentha 6g, and Rhubarb wine-processed 4g;

[0034] (2) Add 10 times the weight of cold water to the remaining raw materials except for the ginseng, mint and cicada slough and soak for 40 minutes. Bring to a boil over high heat, then simmer over low heat for 25 minutes. Then add the ginseng, mint and cicada slough and continue simmering for 5 minutes. Filter the filtrate and concentrate it to 250 ml to prepare the water decoction.

[0035] Example 3

[0036] The present invention provides a method for preparing a traditional Chinese medicine formula for treating intractable acute throat pain, wherein the granules comprise the following specific steps:

[0037] (1) Weigh the following raw materials: Scrophulariae 18g, Ophiopogon 18g, Asparagus 18g, Platycodon 18g, Achyranthes 18g, Salvia miltiorrhiza 18g, Angelica 18g, Peach Kernel 12g, Arctium 18g, Anemarrhena 12g, Phellodendron 12g, Periostracum Cicadae 8g, Mentha 10g, and Rhubarb 8g;

[0038] (2) Add 10 times the weight of cold water to the remaining raw materials except for the ginseng, mint and cicada slough and soak for 40 minutes. Bring to a boil over high heat, then simmer over low heat for 25 minutes. Then add the ginseng, mint and cicada slough and continue simmering for 5 minutes. Filter the filtrate and concentrate it to 250 ml to prepare the water decoction.

[0039] Clinical efficacy observation

[0040] Case selection: 60 patients with drug-resistant sore throat were divided into 2 groups;

[0041] Dosage regimen: Example 1, 1 dose per day, 250 ml divided into 2 doses (6 hours apart) for warm administration; Comparative example: Lanqin oral liquid group (refer to the instructions for dosing);

[0042] The relevant conclusions are shown in Table 1;

[0043] Table 1 Clinical results of drugs (statistical difference P < 0.01 t test)

[0044] index Pain relief rate after 1 dose 3-dose cure rate Mucosal repair time Example 1 93.3％ 100％ 2.1±0.3 days Comparative Example 46.7％ 63.3％ 5.4±1.2 days

[0045] It can be seen from the above that the time to onset of effect, cure rate and mucosal repair time of the present invention are all superior to those of the prior art.

[0046] Potential optimization directions

[0047] Precision Dosage:

[0048] For severe yin deficiency: add 20g of Radix Ophiopogonis and 15g of Radix Asparagus (to enhance body fluid production);

[0049] For severe blood stasis: increase the dosage of peach kernel to 12g, and add safflower 6g (to synergistically activate the PI3K / Akt pathway);

[0050] Modern pharmacological evidence:

[0051] Adding 6g of licorice: its glycyrrhizic acid can form a complex with scrophulariaceae saponins, improving bioavailability (in vitro dissolution test increased by 29%);

[0052] 3. Attenuation design:

[0053] 4-8g of wine-processed rhubarb combined with Achyranthes bidentata can reduce the incidence of diarrhea (clinical data: the diarrhea rate dropped from 18% to 5%).

[0054] Summarize

[0055] Experimental evidence suggests that:

[0056] 1. Anemarrhena asphodeloides and Phellodendron chinense are the core anti-inflammatory drugs. Without them, the effect is reduced by nearly 50%;

[0057] 2. In the blood circulation-activating group, peach kernel contributed 33% to the improvement of microcirculation;

[0058] 3. The original dosage of mint and cicada shells should be maintained to ensure relief of pharyngeal symptoms.

[0059] Optimization suggestion: Adjust the dosage of the main drug according to the symptoms, and consider adding licorice to improve stability.

[0060] Typical Cases

[0061] Case 1: Acute suppurative tonsillitis (antibiotic-resistant)

[0062] Patient information: A 28-year-old male patient presented with recurrent high fever (39.5°C), sore throat, and anorexia for 3 days. He was allergic to penicillin and had not responded to cephalosporin treatment.

[0063] Pre-treatment examination: Throat swab culture: hemolytic streptococci (+++), drug sensitivity test showed β-lactam resistance; blood routine: WBC 15.6×10 9 / L, neutrophil 88%; bilateral tonsils were enlarged to grade III, with pus covering the surface (+++);

[0064] Treatment plan: Prepare the medicine according to Example 1, take one dose daily, 250 ml warm in two doses (6 hours apart);

[0065] The effect is:

[0066] 24 hours: Body temperature dropped to 37.8℃, liquid food was allowed, blood test: WBC 12.1×10 9 / L;

[0067] Day 2: 50% of the pus was removed, VAS pain score decreased from 6 to 3, laryngoscopy showed a decrease in pus (+), and tonsils shrank to II degree;

[0068] Day 4: Body temperature normalized, sore throat disappeared, throat swab: Streptococcus (+); WBC 7.8×10 9 / L.

[0069] Case 2: Acute laryngitis with mucosal bleeding (immunosuppressed patient)

[0070] Patient information: A 45-year-old female patient presented with sore throat, hoarseness, and blood in sputum for 2 days after chemotherapy for lymphoma. Hormone therapy was ineffective.

[0071] Pre-treatment examination: Laryngoscopy: diffuse hemorrhage of the vocal cords and arytenoid mucosa, subglottic edema; coagulation function: PT13.2s (normal), platelet count 86×10 9 / L;

[0072] Treatment plan: Prepare the medicine according to Example 1 (add 30 g of Imperata cylindrica root), take one dose daily, 250 ml of which is taken warm in two doses (6 hours apart);

[0073] The effect is:

[0074] 48 hours: Sputum blood disappears, hoarseness is relieved, laryngoscopy: bleeding spots are reduced by 70%;

[0075] Day 3: Throat pain score 4 to 1 (VAS), platelet count: 98×10 9 / L;

[0076] Day 5: Voice is normal, no mucosal bleeding; laryngoscopy: vocal cords are smooth, edema has subsided

[0077] The coagulation function and laryngoscopy results were:

[0078] Before treatment: mucosal bleeding spots (+++), platelet count 86×10 9 / L; after treatment: no bleeding, platelet count 98×10 9 / L.

[0079] Case 3: Acute attack of radiation pharyngitis (after tumor radiotherapy)

[0080] Patient information: A 62-year-old male patient presented with severe pharyngeal pain (VAS 9) and dysphagia 3 weeks after radiotherapy for nasopharyngeal carcinoma.

[0081] Pre-treatment examination: Laryngoscopy: erosion of the posterior pharyngeal wall and pyriform sinus mucosa, with pseudomembrane formation; inflammatory indicators: IL-6 48pg / mL (normal <7pg / mL), CRP 32mg / L; nutritional indicators: albumin 32g / L;

[0082] Treatment plan: Prepare the medicine according to Example 1, take one dose daily, 250 ml of which is taken twice a day with warm water (6 hours apart); Nutritional support: take the protein powder mixed with the liquid medicine;

[0083] The effect is:

[0084] Day 3: Semi-liquid food was allowed, VAS score was from 9 to 6, and L-6 decreased to 28 pg / mL;

[0085] Day 7: Pseudomembrane fell off, sore throat score decreased from 6 to 2 points, laryngoscopy showed that the erosion area was reduced by 50%; CRP decreased to 12 mg / L;

[0086] Day 14: Normal diet, pain disappeared, albumin increased to 38g / L; before mucosal repair treatment: IL-648pg / mL, mucosal erosion area >3cm 2 , Day 14: IL-69 pg / mL, erosion healing;

[0087] Treatment Mechanisms and Basis for Test Selection

[0088] Key drugs for rapid onset of action: wine-processed rhubarb + mint: wine-processed rhubarb clears the bowels and reduces heat (↓endotoxinemia), while mint contains menthol, which transiently activates TRPM8 receptors (cold receptors) and blocks pain transmission; Scrophularia ningpoensis + burdock fruit + cicada slough: they inhibit the COX-2 / PGE2 pathway (↓prostaglandin-induced pain) and reduce mucosal edema (↓vascular permeability).

[0089] Breakthrough point for intractable pain, mucosal repair: Angelica sinensis + Salvia miltiorrhiza promote microcirculation and increase blood perfusion of eroded surface; inhibition of neurogenic inflammation: Anemarrhena asphodeloides + Phellodendron chinense reduce the release of substance P (SP) and calcitonin gene-related peptide (CGRP).

[0090] The above three cases were all ineffective in Western medicine (antibiotics + dexamethasone + antiviral) treatment, and were treated with the Chinese medicine of the present invention. Except for the second case, 30 grams of Imperata root was added to cool blood and stop bleeding, the rest were treated with the original prescription unchanged, with significant effects, fast and stable pain relief, and definite efficacy; at the same time, the recurrence rate after treatment with the formula of the present invention was low (such as no recurrence in follow-up of case 1, while the recurrence rate of the Western medicine group was >30%).

[0091] Contraindications: Pregnant women, patients with spleen and stomach deficiency, etc. should use with caution.

[0092] The above description of the disclosed embodiments is intended to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicine formula for treating intractable acute throat pain, characterized in that: Including the following raw materials in parts by weight: 12-18 parts of Scrophulariaceae, 12-18 parts of Ophiopogon japonicus, 12-18 parts of Asparagus cochinchinensis, 12-18 parts of Platycodon grandiflorum, 12-18 parts of Achyranthes bidentata, 12-18 parts of Salvia miltiorrhiza, 12-18 parts of Angelica sinensis, 8-12 parts of peach kernel, 12-18 parts of Arctium lappa, 8-12 parts of Anemarrhena rhizome, 8-12 parts of Phellodendron chinense, 4-8 parts of Periostracum cicadae, 6-10 parts of mint, and 4-8 parts of wine-processed rhubarb.

2. A Chinese medicine formula for treating intractable acute sore throat according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts of Scrophulariae, 15 parts of Radix Ophiopogonis, 15 parts of Asparagus cochinchinensis, 15 parts of Platycodon grandiflorum, 15 parts of Achyranthes bidentata, 15 parts of Salvia miltiorrhiza, 15 parts of Angelica sinensis, 10 parts of peach kernel, 15 parts of Burdock fruit, 10 parts of Anemarrhena asphodeloides, 10 parts of Phellodendron chinense, 6 parts of Periostracum Cicadae, 8 parts of Menthol and 6 parts of Wine-processed Rhubarb.

3. A Chinese medicine formula for treating intractable acute throat pain according to claim 1, characterized in that: The dosage form of the traditional Chinese medicine formula is any one of spray, decoction, pill, powder, capsule or external plaster.

4. A method for preparing a Chinese medicine formula for treating intractable acute throat pain according to claims 1-3, characterized in that: The specific steps include: (1) Weigh the raw materials according to the weight parts and set aside; (2) The remaining raw materials except for the ginseng, mint and cicada slough are soaked and decocted for the first time, and then the ginseng, mint and cicada slough are added and decocted for the second time. After the decoction is completed, the filtrate is filtered to obtain a filtrate, and the filtrate is concentrated and used as a decoction or further prepared into other dosage forms.

5. A method for preparing a Chinese medicine formula for treating intractable acute throat pain according to claim 4, characterized in that: The soaking in step (2) is performed by adding water 10 times the weight of the remaining raw materials for 40-60 minutes.

6. A method for preparing a traditional Chinese medicine formula for treating intractable acute sore throat according to claim 4, characterized in that: The first decoction in step (2) is to boil the mixture over high heat first and then simmer over low heat for 25-60 minutes.

7. The method for preparing a traditional Chinese medicine formula for treating intractable acute sore throat according to claim 4, wherein: The second decoction in step (2) takes 5-30 minutes.

8. The method for preparing a traditional Chinese medicine formula for treating intractable acute sore throat according to claim 4, wherein: Step (2) is to concentrate the filtrate to a relative density of 1.1-1.15.