Botanical medicine composition for treating dysentery

Abstract

The invention relates to a botanical medicine composition for treating dysentery, and the botanical medicine composition for treating dysentery is prepared from the following components in parts by mass: 8-16 parts of scorched acorn kernel powder, 5-15 parts of scorched bamboo sawdust and 10-20 parts of scorched rhizoma nelumbinis. The scorched acorn kernel powder and the scorched lotus rhizome node are rich in tannin, can protect intestinal tracts, reduce irritation of pathogens and bacterial toxins to intestinal mucosa, and play a role in astringing to arrest diarrhea. Nodus nelumbinis rhizomatis is astringent in taste, has the effects of astringing, stopping bleeding and stopping diarrhea and can be used for various bleeding syndromes, bamboo sawdust is cold in nature and can clear away heat and dry dampness, after the Nodus nelumbinis rhizomatis and the bamboo sawdust are fried to be scorched, the effect of tonifying the spleen and stopping diarrhea is achieved by means of scorched aroma, and a certain conditioning effect on dyspepsia and diarrhea caused by weakness of the spleen and the stomach is achieved. The three medicines are combined to achieve the effects of astringing to arrest diarrhea, tonifying spleen, eliminating dampness and stopping dysentery. The traditional Chinese medicine composition has the advantages of low raw material cost, safety, low toxicity and remarkable curative effect.

Description

Technical Field

[0001] The invention belongs to the technical field of botanical preparations, and particularly relates to a botanical composition for treating dysentery. Background Art

[0002] Dysentery, a disease in Traditional Chinese Medicine (TCM), is a common intestinal infectious disease characterized by increased bowel movement, abdominal pain, anal distension, uncomfortable bowel movements, and the discharge of bloody, reddish-white pus. The primary etiology is exogenous pathogenic factors, including epidemic toxins, and internal injuries caused by unclean food. The primary pathogenesis of dysentery is damp-heat, cold-dampness, and epidemic toxins that stagnate the intestines, leading to qi and blood stasis and dysfunctional large intestine conduction, resulting in dysentery. Sudden dysentery is often a sign of excess, while chronic dysentery is often a sign of deficiency.

[0003] For the treatment of dysentery, for damp-heat dysentery, it is advisable to clear away heat and dampness, regulate qi and activate blood circulation; for cold-damp dysentery, it is advisable to warm and eliminate cold and dampness, promote qi circulation and remove stagnation; for epidemic dysentery, it is advisable to clear away heat and detoxify, cool blood and open the orifices; for deficiency-cold dysentery, it is advisable to warm and tonify the spleen and kidney, consolidate and astringe to stop dysentery; for infectious bacterial dysentery and amoebic dysentery, the emphasis should be on prevention and control of infection, and quinolone antibiotics or nitroimidazole drugs should be used when necessary.

[0004] Acorns are the fruit of trees in the genus Quercus in the Fagaceae family. After the acorn is shelled, the seed inside is the acorn kernel. Lotus nodes are the dried rhizome nodes of the lotus plant in the Nymphaeaceae family. These nodes are typically harvested in autumn and winter, cut, washed, sun-dried, and the fibrous roots removed. The therapeutic effects of burnt acorn kernel powder and burnt lotus nodes on dysentery are primarily due to their rich content of tannins (tannic acid), a natural polyphenol with remarkable astringent, antibacterial, and anti-inflammatory properties. After the acorn is roasted and shelled, the kernel is crushed and roasted for medicinal use. Tannic acid rapidly acts on the intestinal mucosa: first, it binds to intestinal proteins to form a protective layer, reducing intestinal fluid secretion and relieving diarrhea, a process known in Traditional Chinese Medicine as "astringent intestines and diarrhea-relieving." Second, it coagulates the proteins of pathogenic microorganisms, inhibiting the activity of pathogens such as Shigella and amoebas.

[0005] In addition, scorched lotus root node powder has astringent and hemostatic effects, can promote vasoconstriction, accelerate platelet aggregation, and thus reduce the amount of bleeding. It is often used clinically for various blood symptoms.

[0006] Bamboo, a perennial herbaceous plant of the genus Bambusa in the Poaceae family, is crushed into granular or powdered solids called bamboo shavings. The small amount of active substances (such as phenols and flavonoids) contained in bamboo shavings have antibacterial properties, inhibiting the growth of pathogens such as Shigella dysenteriae and alleviating intestinal infections. The charred aroma of lotus root nodes and bamboo shavings, when charred, benefits the spleen and alleviates loss of appetite and indigestion caused by spleen and stomach deficiency. They are often used in combination with spleen-tonifying herbs such as Atractylodes macrocephala and Poria cocos. Summary of the Invention

[0007] The present invention provides a botanical medicine composition for treating dysentery. The synergistic effect of scorched acorn kernel powder, scorched bamboo chips and scorched lotus root node powder can protect the intestines, assist the spleen in transportation and transformation, enhance the overall anti-dysentery ability of the composition, and has excellent efficacy in treating dysentery.

[0008] In order to achieve the purpose of the present invention, the technical solution of the present invention is as follows:

[0009] A botanical medicine composition for treating dysentery is composed of the following materials in parts by weight: 8-16 parts by weight of burnt acorn kernel powder, 5-15 parts by weight of burnt bamboo chips, 10-20 parts by weight of burnt lotus root nodes, and 0.1-0.8 parts by weight of a dispersant.

[0010] Furthermore, the preparation method comprises the following steps:

[0011] S1: Take acorn kernels, stir-fry at 125℃~165℃ for 10~15 minutes, take out and let cool, then sieve.

[0012] S2: Take bamboo chips with an average particle size of 10-50 mesh, stir-fry them at 80-130°C for 10-15 minutes, then stir-fry them at 120-175°C for 5-15 minutes until they turn brown, take them out, let them cool, and sieve them.

[0013] S3: Take lotus root nodes, stir-fry them at 100℃~130℃ for 10~35 minutes, then stir-fry them at 150℃~200℃ for 5~15 minutes, take out the charred lotus root nodes, let them cool, crush them and sieve them.

[0014] S4: Take the scorched acorn kernel powder, scorched bamboo chips and scorched lotus root node powder prepared in S1, S2 and S3, mix them evenly with a dispersant, and obtain the product.

[0015] Furthermore, a 90-120 mesh sieve is used for sieving in the preparation steps S1, S2, and S3.

[0016] Furthermore, the dispersant in the composition is a mixture of one or more of sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, gum arabic, and sodium alginate.

[0017] Furthermore, the herbal medicine composition is characterized in that it is for oral administration and is taken with water, with the amount of water being 0.5 to 10 times the total mass of the composition.

[0018] Compared with existing technologies, the present invention offers advantages in that the botanical drug composition provided by the present invention combines the tannins in the charred lotus root nodes with intestinal proteins to form a protective layer, protecting the intestines from external pathogenic microorganisms and their toxins. Lotus root nodes are astringent, stop bleeding, and relieve diarrhea, while bamboo chips clear heat and dry dampness. The charred aroma of the lotus root nodes and bamboo chips, when charred, is said to invigorate the spleen and relieve diarrhea, and has a conditioning effect on indigestion and diarrhea caused by spleen and stomach deficiency.

[0019] The invention has the advantages of low raw material cost, safety, low toxicity and significant therapeutic effect. DETAILED DESCRIPTION

[0020] The present invention is further explained below with reference to the following examples, but the examples do not limit the present invention in any form.

[0021] Example 1

[0022] Take the acorn kernels, stir-fry at 135℃ for 10 minutes, take them out and let them cool, then pass them through a 110-mesh sieve and set aside.

[0023] Take bamboo chips with an average particle size of 20 mesh, stir-fry them at 120℃ for 10 minutes, then stir-fry them at 155℃ for 15 minutes, until the bamboo chips turn brown, take them out and let them cool, then pass them through a 110 mesh sieve and set aside.

[0024] Take the lotus root nodes, stir-fry them at 125℃ for 15 minutes, then stir-fry them at 165℃ for 12 minutes. Take out the charred lotus root nodes, let them cool, crush them, pass them through a 110-mesh sieve, and set aside.

[0025] Take 15 grams of scorched acorn kernel powder, 12 grams of scorched bamboo chips, 9 grams of scorched lotus root node powder and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical medicine composition for treating dysentery.

[0026] Example 2

[0027] Take 12 grams of scorched acorn kernel powder, 15 grams of scorched bamboo chips, 9 grams of scorched lotus root node powder, and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical composition for treating dysentery. The preparation methods of scorched acorn kernel powder, scorched bamboo chips, and scorched lotus root node powder are all prepared according to the method in Example 1.

[0028] Example 3

[0029] Take 9 grams of scorched acorn kernel powder, 15 grams of scorched bamboo chips, 12 grams of scorched lotus root node powder, and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical composition for treating dysentery. The preparation methods of scorched acorn kernel powder, scorched bamboo chips, and scorched lotus root node powder are all prepared according to the method in Example 1.

[0030] Example 4

[0031] Take 9 grams of scorched acorn kernel powder, 12 grams of scorched bamboo chips, 15 grams of scorched lotus root node powder, and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical composition for treating dysentery. The preparation methods of scorched acorn kernel powder, scorched bamboo chips, and scorched lotus root node powder are all prepared according to the method in Example 1.

[0032] Example 5

[0033] Take 15 grams of scorched acorn kernel powder, 9 grams of scorched bamboo chips, 12 grams of scorched lotus root node powder, and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical composition for treating dysentery. The preparation methods of scorched acorn kernel powder, scorched bamboo chips, and scorched lotus root node powder are all prepared according to the method in Example 1.

[0034] Example 6

[0035] Take 12 grams of scorched acorn kernel powder, 9 grams of scorched bamboo chips, 15 grams of scorched lotus root node powder, and 0.5 grams of sodium alginate, mix them thoroughly, and you can get a botanical composition for treating dysentery. The preparation methods of scorched acorn kernel powder, scorched bamboo chips, and scorched lotus root node powder are all prepared according to the method in Example 1.

[0036] Comparative Example 1

[0037] Take 36 grams of burnt acorn kernel powder and 0.5 grams of sodium alginate and mix them thoroughly. The burnt acorn kernel powder is prepared according to the method of Example 1.

[0038] Comparative Example 2

[0039] Take 36 grams of charred bamboo chips and 0.5 grams of sodium alginate and mix them thoroughly. The preparation method of the charred bamboo chips is the same as that of Example 1.

[0040] Comparative Example 3

[0041] Take 36 grams of scorched lotus root node powder and 0.5 grams of sodium alginate and mix them thoroughly. The preparation method of the scorched lotus root node powder is the same as that of Example 1.

[0042] The raw materials used in the present invention are supplied by the following manufacturers

[0043] Acorn kernels were purchased from Huadian Longxiang Acorn Development Co., Ltd. as dry products; bamboo chips were purchased from Fujian Weijia Living Products Manufacturing Co., Ltd. as dry products; lotus root nodes were purchased from Yurun Agricultural and Sideline Products Management Department in Qiaocheng District, Bozhou City as dry products.

[0044] Efficacy experiments

[0045] 110 ICR mice, aged 4 to 6 weeks and weighing 18-22 g, were randomly divided into 11 groups, each with 10 mice, half male and half female; they were a positive control group (10 mg / ml levofloxacin hydrochloride purified aqueous solution), a blank control group (0.9% sodium chloride solution), Example groups 1-6, and Comparative Example groups 1-3. The bacterial dysentery model was established using Escherichia coli, with 5×10 8CFU / ml, 0.2 ml per 10 grams of body weight, intraperitoneal injection. After the mice developed diarrhea, all mice in the Example and Comparative Example groups were gavage-administered with the drug powder mixed with an equal weight of water, at a drug dosage of 0.8% of the mouse body weight. Mice in the positive control group were gavage-administered with a 10 mg / ml levofloxacin hydrochloride aqueous solution at a gavage volume of 2 ml / 100 g of mouse body weight. Mice in the blank control group were gavage-administered with a 0.9% sodium chloride solution at a gavage volume of 2 ml / 100 g of mouse body weight.

[0046] Observe the amount of stool (expressed as the number of dry fecal pellets or loose stool piles) and the diarrhea rate (the presence of unformed loose stools as an indicator of diarrhea) 1 hour before dosing and every hour after dosing for 4 consecutive hours. Dry fecal pellets were counted directly, and loose stools were measured by piles (each pile ≥ 3g was considered 1 unit). Diarrhea was determined as the presence of unformed loose stools. Diarrhea rate = number of animals with diarrhea / total number of animals × 100%.

[0047] During the experiment, mice were free to drink water and eat. Finally, the amount of feces during the period of maximum feces (1-3 hours) after drug administration and the diarrhea rate of mice within 1-4 hours were used as indicators for statistical analysis. The results are shown in Table 1.

[0048] Table 1: Effects of the herbal drug combination on diarrhea rate and fecal volume in mice with bacillary dysentery

[0049]

[0050] The results showed that the diarrhea rate and stool volume of mice in the positive control group were lower than those in the blank control group, indicating that the drug experimental design was reasonable. The mice in Example 5 had the smallest stool volume and the lowest diarrhea rate after administration, only 10%, which was the best effect among the six groups of examples. Compared with the blank control group (pure 0.9% sodium chloride solution), Example groups 1 to 6 had a significant antidiarrheal effect.

[0051] As shown in Table 1, the diarrhea rate and stool volume of the mice in any of the examples were lower than those in the mice in Comparative Examples 1, 2, and 3. Among them, Example 5 was the preferred formulation of the present application and had the best effect. The formulations in the comparative examples all contained only one of the charred acorn kernel powder, charred bamboo chips, and charred lotus root node powder, and the effects of treating dysentery were poor. Therefore, it can be seen that the present invention's use of the charred acorn kernel powder, charred bamboo chips, and charred lotus root node powder together to treat dysentery is more effective than using the charred acorn kernel powder, charred bamboo chips, or charred lotus root node powder alone to treat dysentery.

[0052] The above only lists the preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any changes made by those skilled in the art within the scope of the claims of the present invention shall fall within the protection scope of the present invention.

Claims

1. A herbal medicine composition for treating dysentery, characterized in that: The composition is prepared by mixing 8-16 weight parts of burnt acorn kernel powder (component A), 5-15 weight parts of burnt bamboo chips (component B), 10-20 weight parts of burnt lotus root nodes (component C) and 0.1-0.8 weight parts of a dispersant.

2. The herbal medicine composition according to claim 1, wherein The preparation method comprises the following steps: S1: Stir-fry acorn kernels at 125°C to 165°C for 10 to 15 minutes, remove and allow to cool, then sieve through a 90-120 mesh sieve. S2: Take bamboo chips with an average particle size of 10-50 mesh, stir-fry at 80-130°C for 10-15 minutes, then stir-fry at 120-175°C for 5-15 minutes until the bamboo chips turn brown, remove and let cool, and pass through a 90-120 mesh sieve; S3: Take lotus root nodes, stir-fry them at 100°C to 130°C for 10 to 35 minutes, then stir-fry them at 150°C to 200°C for 5 to 15 minutes, remove the burnt lotus root nodes, let them cool, crush them, and sieve them through a 90-120 mesh sieve; S4: Take the scorched acorn kernel powder, scorched bamboo chips and scorched lotus root node powder prepared in S1, S2 and S3, and mix them evenly with the dispersant to obtain the product.

3. The herbal medicine composition according to claim 1, wherein The dispersant is a mixture of one or more of sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, gum arabic and sodium alginate.

4. The herbal medicine composition according to claim 1, wherein For oral administration, take with water, the amount of water being 0.5 to 10 times the total mass of the composition.

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