Traditional Chinese medicine composition for treating deficiency of both qi and yin and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating deficiency of both qi and yin and application of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following components: 60-70 g of radix ophiopogonis, 7-15 g of red ginseng, 15-20 g of teasel root, 15-20 g of wine-processed fructus corni, 10-20 g of vinegar-processed tortoise shell, 7-15 g of ginger processed pinellia, 10-18 g of immature bitter orange, 10-15 g of artemisia anomala, 4-10 g of dried ginger, 7-15 g of cassia twig, 7-15 g of liquorice and 10-20 g of Chinese date, the whole formula embodies the compatibility intelligence of dredging upper energizer, dredging middle energizer and filling lower energizer, and the traditional Chinese medicine composition is clinically used for treating deficiency of both qi and yin, the symptoms comprise palpitation, chest distress, depression, insomnia, cough, dry throat, soreness of waist, weakness and the like, and the qi-yin deficiency syndrome can be effectively improved and treated.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating qi and yin deficiency syndrome and application thereof. Background Art

[0002] Qi and Yin deficiency syndrome itself is a complex syndrome characterized by the coexistence of both Qi and Yin deficiency. Its pathological mechanisms involve multiple organs and multiple aspects, including Qi, blood, and body fluids. Treatment requires a balanced approach to tonifying Qi and nourishing Yin, which increases the complexity of treatment. Patients with Qi and Yin deficiency syndrome often experience multiple concurrent symptoms, including stasis, phlegm, dampness, and heat. For example, Qi deficiency can weaken blood circulation, leading to endogenous blood stasis and a combined syndrome of stasis. Yin fluid deficiency, resulting in insufficient blood flow through the meridians, further exacerbates blood stasis, and blood stasis. Stagnation in the blood vessels impedes the circulation of body fluids, leading to the formation of phlegm and dampness. The stagnant phlegm and dampness, in turn, hinder the flow of Qi, exacerbating blood stasis. Residual heat can simmer body fluids, refining them into phlegm. Prolonged accumulation of phlegm, dampness, and blood stasis can transform into heat, leading to a complex syndrome.

[0003] Currently commonly used classic prescriptions such as Shengmai San, Zhigancao Tang, and Shenqi Dihuang Tang primarily target specific viscera (heart and lungs / heart / spleen and kidney) for Qi and Yin deficiency syndromes, treating symptoms such as palpitations, shortness of breath, irregular pulse, or edema and loose stools. However, these prescriptions focus on a single viscera or syndrome (e.g., liver and kidney Yin deficiency, lung and stomach Yin deficiency), lack coordinated regulation of the three energizers, and suffer from dosage form limitations (traditional honey pills are greasy and irritating to the stomach, while syrup preparations have a single effect). These limitations make them difficult to meet the holistic regulation needs of complex Qi and Yin deficiency syndromes, limiting their clinical effectiveness.

[0004] In view of this, the present invention is proposed. Summary of the Invention

[0005] One of the purposes of the present invention is to provide a Chinese medicine composition for treating Qi and Yin deficiency syndrome, so as to solve the technical problem in the prior art of lacking a Chinese medicine composition that can improve or treat a variety of Qi and Yin deficiency syndrome related diseases.

[0006] The second object of the present invention is to provide a Chinese medicine extract for treating Qi and Yin deficiency syndrome.

[0007] A third object of the present invention is to provide a Chinese medicine preparation for treating Qi and Yin deficiency syndrome.

[0008] A fourth object of the present invention is to provide the use of the above-mentioned traditional Chinese medicine composition, the above-mentioned traditional Chinese medicine extract or the above-mentioned traditional Chinese medicine preparation in the preparation of a medicine for treating qi and yin deficiency syndrome.

[0009] A fifth object of the present invention is to provide the use of the above-mentioned Chinese medicine composition, the above-mentioned Chinese medicine extract or the above-mentioned Chinese medicine preparation in medicines for treating palpitations, chest tightness, depression, insomnia, cough, dry throat, back pain or fatigue.

[0010] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are adopted:

[0011] In the first aspect, the present invention provides a traditional Chinese medicine composition for treating qi and yin deficiency syndrome, comprising the following components: 60-70g of Ophiopogon japonicus, 7-15g of red ginseng, 15-20g of Dipsacus asper, 15-20g of Cornus officinalis with wine, 10-20g of tortoise shell with vinegar, 7-15g of Pinellia ternata with ginger, 10-18g of Citrus aurantium, 10-15g of Northern Liujienu, 4-10g of dried ginger, 7-15g of cinnamon twig, 7-15g of licorice, and 10-20g of jujube.

[0012] Furthermore, it includes the following components: 63g of Ophiopogon japonicus, 9g of Red Ginseng, 18g of Dipsacus asper, 18g of Cornus officinalis with wine, 18g of Tortoise Shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Northern Liujienu, 6g of dried ginger, 9g of cinnamon twig, 9g of liquorice, and 15g of jujube.

[0013] In a second aspect, the present invention provides a traditional Chinese medicine extract for treating qi and yin deficiency syndrome, which is extracted from traditional Chinese medicine raw materials. The traditional Chinese medicine raw materials include the following components: 60-70g of Ophiopogon japonicus, 7-15g of Red Ginseng, 15-20g of Dipsacus asper, 15-20g of Cornus officinalis with wine, 10-20g of Tortoise Shell with vinegar, 7-15g of Pinellia ternata with ginger, 10-18g of Citrus aurantium, 10-15g of Northern Liujienu, 4-10g of dried ginger, 7-15g of cinnamon twig, 7-15g of licorice, and 10-20g of jujube.

[0014] Furthermore, the Chinese medicinal raw materials include the following components: 63g of Ophiopogon japonicus, 9g of red ginseng, 18g of Dipsacus asper, 18g of Cornus officinalis with wine, 18g of tortoise shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Northern Liujienu, 6g of dried ginger, 9g of cinnamon twig, 9g of licorice, and 15g of jujube.

[0015] In a third aspect, the present invention provides a traditional Chinese medicine preparation for treating Qi and Yin deficiency syndrome, comprising the above-mentioned traditional Chinese medicine composition or the above-mentioned traditional Chinese medicine extract.

[0016] Furthermore, the dosage form of the traditional Chinese medicine preparation includes at least one of pills, decoctions, tablets, pastes, powders, granules, mixtures, oral liquids or capsules.

[0017] In a fourth aspect, the present invention provides use of the aforementioned traditional Chinese medicine composition, the aforementioned traditional Chinese medicine extract, or the aforementioned traditional Chinese medicine preparation in the preparation of a medicine for treating Qi and Yin deficiency syndrome.

[0018] Furthermore, the Qi and Yin deficiency syndrome includes Qi and Yin deficiency diseases of the heart and lungs.

[0019] Furthermore, the heart and lung qi and yin deficiency disease includes at least one of palpitations, chest pain, depression, insomnia, cough and fatigue of qi and yin deficiency syndrome.

[0020] In a fifth aspect, the present invention provides the use of the aforementioned traditional Chinese medicine composition, the aforementioned traditional Chinese medicine extract or the aforementioned traditional Chinese medicine preparation in the preparation of any of the following medicines:

[0021] A1. Medications for treating palpitations;

[0022] A2. Drugs for treating chest pain;

[0023] A3. Medications for treating depression;

[0024] A4. Medications for treating insomnia;

[0025] A5. Medicines for treating cough;

[0026] A6. Medicines for treating asthenia.

[0027] Compared with the prior art, the Chinese medicine composition for treating Qi and Yin deficiency provided by the present invention has the following beneficial effects:

[0028] (1) Triple Burner Synergy: Ophiopogon japonicus nourishes the upper burner, Citrus aurantium promotes Qi flow in the middle burner, Dipsacus asper (adjuvant) nourishes the liver and kidneys and strengthens the tendons and bones, and Vinegar and Turtle Shell (minister) nourishes Yin and suppresses Yang, achieving "unblocked upper burner, unblocked middle burner, and full lower burner", suitable for long-term conditioning of chronic diseases;

[0029] (2) Long-lasting and safe: Four years of clinical validation have shown an efficacy of 95% and safe tolerance. Long-term use can effectively improve core symptoms such as palpitations, chest tightness, cough, and dry throat caused by Qi and Yin deficiency.

[0030] The whole formula embodies the compatibility relationship of "promoting the upper burner, unblocking the middle burner, and filling the lower burner". It is clinically used for the syndrome of both qi and yin deficiency, with symptoms such as palpitations, chest tightness, depression, insomnia, cough, dry throat, low back pain and fatigue, etc. It can effectively improve the treatment of the syndrome of both qi and yin deficiency. DETAILED DESCRIPTION

[0031] Unless otherwise defined herein, scientific and technical terms used in conjunction with the present invention shall have the meanings commonly understood by those of ordinary skill in the art. The meaning and scope of the terms should be clear; however, in the event of any potential ambiguity, the definitions provided herein take precedence over any dictionary or external definitions. In this application, the use of "or" means "and / or" unless otherwise stated. In addition, the use of the term "including" and other forms is non-limiting.

[0032] The methods and techniques of the present invention are generally performed according to conventional methods well known in the art and as described in various general and more specific references that are cited and discussed throughout the present specification unless otherwise indicated.

[0033] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0034] On the one hand, the present invention provides a traditional Chinese medicine composition for treating qi and yin deficiency syndrome, comprising the following components: 60-70g of ophiopogon japonicus, 7-15g of red ginseng, 15-20g of dipsaccharin, 15-20g of cornus fruit with wine, 10-20g of tortoise shell with vinegar, 7-15g of pinellia ternata with ginger, 10-18g of immature bitter orange, 10-15g of northern liujiu, 4-10g of dried ginger, 7-15g of cassia twig, 7-15g of liquorice, and 10-20g of jujube.

[0035] The whole formula uses Ophiopogon japonicus as the main ingredient to nourish yin and clear away heat, red ginseng to replenish qi, and cornus officinalis and tortoise shell with wine and vinegar to nourish the liver and kidneys as the auxiliary ingredients, which together achieve the effect of nourishing both qi and yin and the common origin of the liver and kidneys; Pinellia ternata to resolve phlegm and reduce adverse effects, Citrus aurantium to guide qi stagnation, Rhizoma Coptidis to promote blood circulation and dredge meridians, and Dipsacus asper to nourish the liver and kidneys and strengthen the bones and muscles as the auxiliary ingredients, to prevent excessive nourishment of yin and the generation of phlegm; cinnamon twig to warm and dredge the meridians, and dried ginger to warm the middle and dispel cold as the auxiliary ingredients, in line with the purpose of "seeking yin in yang"; jujube and licorice as the messengers, to harmonize the various medicines and nourish the heart and calm the mind. Specifically, it has the following advantages: (1) Triple Burner Synergy: Ophiopogon japonicus nourishes the upper burner, Citrus aurantium promotes Qi flow in the middle burner, Dipsacus asper (adjuvant) nourishes the liver and kidneys and strengthens the bones and tendons, and Vinegar and Turtle Shell (minister) nourishes Yin and suppresses Yang, achieving "unblocking the upper burner, unblocking the middle burner, and filling the lower burner", which is suitable for long-term conditioning of chronic diseases; (2) Long-term safety: Four years of clinical verification, the efficacy is 95% and it is safe and tolerable. Long-term use can effectively improve the core symptoms of Qi and Yin deficiency syndrome, such as palpitations, chest tightness, cough, and dry throat. The whole formula embodies the compatibility relationship of "unblocking the upper burner, unblocking the middle burner, and filling the lower burner". It is clinically used for Qi and Yin deficiency syndrome, with symptoms such as palpitations, chest tightness, depression, insomnia, cough, dry throat, low back pain and fatigue, etc., and can effectively improve the treatment of Qi and Yin deficiency syndrome.

[0036] The weight of the Ophiopogon japonicus may be, but is not limited to, 60g, 61g, 62g, 63g, 64g, 65g, 66g, 67g, 68g, 69g or 70g, or any value between 60 and 70g.

[0037] The weight of the red ginseng may be, but is not limited to, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g or 15g, or any value between 7 and 15g.

[0038] The weight of the teasel can be but is not limited to 15g, 15.5g, 16g, 16.5g, 17g, 17.5g, 18g, 18.5g, 19g, 19.5g or 20g, and can also be any value between 15 and 20g.

[0039] The weight of the wine-cooked cornus fruit can be but is not limited to 15g, 15.5g, 16g, 16.5g, 17g, 17.5g, 18g, 18.5g, 19g, 19.5g or 20g, and can also be any value between 15 and 20g.

[0040] The weight of the vinegar tortoise shell can be, but is not limited to, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g, 19g or 20g, and can also be any value between 10 and 20g.

[0041] The weight of the ginger pinellia can be, but is not limited to, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g or 15g, and can also be any value between 7 and 15g.

[0042] The weight of the Fructus Aurantii Immaturus may be, but is not limited to, 10 g, 11 g, 12 g, 13 g, 14 g, 15 g, 16 g, 17 g or 18 g, and may be any value between 10 and 18 g.

[0043] The weight of the Northern Liujinu can be but is not limited to 10g, 10.5g, 11g, 11.5g, 12g, 12.5g, 13g, 13.5g, 14g, 14.5g or 15g, and can also be any value between 10 and 15g.

[0044] The weight of the dried ginger may be, but is not limited to, 4g, 5g, 6g, 7g, 8g, 9g or 10g, or any value between 4 and 10g.

[0045] The weight of the cassia twig can be, but is not limited to, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g or 15g, and can also be any value between 7 and 15g.

[0046] The weight of the licorice can be, but is not limited to, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g or 15g, and can also be any value between 7 and 15g.

[0047] The weight of the jujube can be, but is not limited to, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g, 19g or 20g, and can also be any value between 10 and 20g.

[0048] In some specific embodiments, the composition includes: 63g of Ophiopogon japonicus, 9g of Red Ginseng, 18g of Dipsacus asper, 18g of Cornus officinalis with wine, 18g of Tortoise Shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Ligusticum wallichii, 6g of dried ginger, 9g of cinnamon twig, 9g of liquorice, and 15g of jujube.

[0049] According to another aspect of the present invention, a traditional Chinese medicine extract for treating qi and yin deficiency syndrome is provided, which is extracted from traditional Chinese medicine raw materials. The traditional Chinese medicine raw materials include the following components: 60-70g of Ophiopogon japonicus, 7-15g of Red Ginseng, 15-20g of Dipsacus asper, 15-20g of Cornus officinalis with wine, 10-20g of Tortoise Shell with vinegar, 7-15g of Pinellia ternata with ginger, 10-18g of Citrus aurantium, 10-15g of Ligusticum wallichii, 4-10g of dried ginger, 7-15g of cinnamon twig, 7-15g of licorice, and 10-20g of jujube.

[0050] In some specific embodiments, the Chinese medicinal raw materials include the following components: 63g of Ophiopogon japonicus, 9g of Red Ginseng, 18g of Dipsacus asper, 18g of Cornus officinalis with wine, 18g of Tortoise Shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Northern Liujienu, 6g of dried ginger, 9g of cinnamon twig, 9g of licorice, and 15g of jujube.

[0051] According to another aspect of the present invention, a traditional Chinese medicine preparation for treating Qi and Yin deficiency syndrome is provided, comprising the above-mentioned traditional Chinese medicine composition or the above-mentioned traditional Chinese medicine extract.

[0052] In some specific embodiments, the dosage form of the Chinese medicine preparation includes at least one of pills, decoctions, tablets, pastes, powders, granules, mixtures, oral liquids or capsules, preferably pills. The pills and the concentration process are used to improve the durability of the drug effect, adapt to the long-term conditioning of chronic diseases, and take into account portability.

[0053] According to another aspect of the present invention, there is also provided a use of the above-mentioned traditional Chinese medicine composition, the above-mentioned traditional Chinese medicine extract or the above-mentioned traditional Chinese medicine preparation in preparing a medicine for treating Qi and Yin deficiency syndrome.

[0054] In some specific embodiments, the Qi and Yin deficiency syndrome includes Qi and Yin deficiency of the heart and lungs.

[0055] In some specific embodiments, the heart and lung qi and yin deficiency disease includes at least one of palpitations, chest pain, depression, insomnia, cough and asthenia of qi and yin deficiency syndrome.

[0056] According to another aspect of the present invention, there is also provided the use of the above-mentioned Chinese medicine composition, the above-mentioned Chinese medicine extract or the above-mentioned Chinese medicine preparation in the preparation of any of the following medicines:

[0057] A1. Medications for treating palpitations;

[0058] A2. Drugs for treating chest pain;

[0059] A3. Medications for treating depression;

[0060] A4. Medications for treating insomnia;

[0061] A5. Medicines for treating cough;

[0062] A6. Medicines for treating asthenia.

[0063] The present invention is further described below by way of examples. Unless otherwise specified, the materials in the examples were prepared according to existing methods or directly purchased from the market.

[0064] Example 1

[0065] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 18g of dipsera root, 18g of cornus fruit with wine, 18g of tortoise shell with vinegar, 9g of pinellia tuber with ginger, 15g of immature bitter orange, 12g of northern liujiu, 6g of dried ginger, 9g of cassia twig, 9g of liquorice, and 15g of jujube.

[0066] Example 2

[0067] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 60g of ophiopogon japonicus, 7g of red ginseng, 20g of dipsera root, 20g of cornus fruit with wine, 18g of tortoise shell with vinegar, 15g of pinellia tuber with ginger, 10g of immature bitter orange, 10g of northern liujiu, 10g of dried ginger, 15g of cassia twig, 15g of liquorice, and 10g of jujube.

[0068] Example 3

[0069] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 70g of ophiopogon japonicus, 15g of red ginseng, 15g of dipsaccharin, 15g of cornus fruit with wine, 18g of tortoise shell with vinegar, 7g of pinellia ternata with ginger, 18g of immature bitter orange, 15g of northern liujiu, 4g of dried ginger, 7g of cassia twig, 7g of liquorice, and 20g of jujube.

[0070] Comparative Example 1

[0071] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 18g of cornus officinalis with wine, 6g of dried ginger, 9g of cassia twig, and 15g of jujube.

[0072] Comparative Example 2

[0073] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 18g of dipsera root, 18g of cornus officinalis with wine, 9g of pinellia tuber, 6g of dried ginger, 9g of cassia twig, and 15g of jujube.

[0074] Comparative Example 3

[0075] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 18g of cornus fruit with wine, 18g of tortoise shell with vinegar, 6g of dried ginger, 9g of cinnamon twig, 9g of liquorice, and 15g of jujube.

[0076] Comparative Example 4

[0077] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 18g of cornus officinalis, 12g of northern liujiu, 6g of dried ginger, 9g of cassia twig, and 15g of jujube.

[0078] Comparative Example 5

[0079] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 10g of dipspermum officinale, 18g of cornus officinalis with wine, 5g of tortoise shell with vinegar, 5g of pinellia ternata with ginger, 15g of immature bitter orange, 5g of northern liujiu, 6g of dried ginger, 9g of cassia twig, 9g of liquorice, and 15g of jujube.

[0080] Comparative Example 6

[0081] A traditional Chinese medicine composition for treating qi and yin deficiency syndrome comprises 63g of ophiopogon japonicus, 9g of red ginseng, 25g of dipspermum officinale, 18g of cornus officinalis with wine, 25g of tortoise shell with vinegar, 20g of pinellia ternata with ginger, 15g of immature bitter orange, 20g of northern liujiu, 6g of dried ginger, 9g of cassia twig, 9g of liquorice, and 15g of jujube.

[0082] Examples 4 to 6

[0083] A Chinese medicine extract of a Chinese medicine composition is prepared by selecting the formulas of Examples 1 to 3 respectively, and following the steps of: soaking the Chinese medicine raw material in 2 times the volume of water for 60 minutes, boiling it over high heat and then decocting it over low heat for 120 minutes, taking out the extract, repeating the above operation once, and mixing the two extracts for later use.

[0084] Comparative Examples 7 to 12

[0085] The difference from Example 4 is that the formulations of Comparative Examples 1 to 6 are respectively selected for preparation.

[0086] Animal experiments

[0087] 1. Experimental Animals: Healthy male Sprague Dawley rats, weighing 240-260 g, were divided into a model group and a normal group. The experiment was conducted after 1 week of adaptive feeding.

[0088] 2. Preparation of rats with Qi and Yin deficiency model: According to the method reported in the literature by Ma Mulan (see Ma Mulan et al., "Study on the efficacy of different processed products of Polygonatum sibiricum on rats with Qi and Yin deficiency model", Shanghai Journal of Traditional Chinese Medicine, 2019, No. 53(10), pp. 83-89), 250 g each of cinnamon, dried ginger, pepper and chili were added to distilled water at a liquid-to-material ratio of 10:1, and decocted for 50 minutes for the first time. After the decoction was poured out, distilled water was added and decocted for 40 minutes. The two decoctions were combined and concentrated to 1000 mL, with each mL containing 1.0 g of crude drug to obtain the modeling hot medicine. The model group rats were given 10 g·kg -1 ·d -1 The rats were administrated orally with a dose of 20 g of rubber wrapped around their tails and swam in a water tank at a temperature of (20±0.5)°C and a depth of 50 cm until exhaustion (the tip of the rat's nose was submerged in the water for 10 seconds).

[0089] The model group rats were given 30% of their basal food intake (12g) daily and gavaged with the modeling drug at 10mL / kg. Rats also swam once daily. A 20g rubber band was wrapped around the rat's tail and placed in a water tank at a temperature of (35±2)°C and a depth of 45cm. The rats swam until exhaustion (the tip of the rat's nose was submerged in the water for 5 seconds). The modeling drug was administered orally once daily and the weighted swimming session was performed once daily for two consecutive weeks.

[0090] 3. Grouping and administration: The rats in the model group with successful modeling were divided into 1 control group and 9 experimental groups, each with 8 rats. The experimental groups were given the Chinese herbal extracts prepared in Examples 4 to 6 and Comparative Examples 7 to 12, respectively, and were recorded as administration groups 1 to 9. Each rat was gavaged with 10 g / kg per day, and the model group was gavaged with the same amount of drinking water. The administration period was 6 weeks. During the 1st to 4th week of administration, 30% of the basal food intake was given to the rats every day. At the same time, the thermal modeling drug (10 g / kg) was gavaged every 3 days. During the 5th to 6th week of administration, the gavage of the thermal modeling drug was stopped, and the rats resumed their normal diet and weight-bearing swimming.

[0091] 4. Observation of the general condition of rats: observe the rats' mental state, activity and coat color.

[0092] 5. Test indicators: The body weight and grip strength of the rats were recorded before modeling, after modeling, and 2 weeks, 4 weeks, and 6 weeks after drug administration. The grip strength measurement included grasping the rat at the base of its tail, placing the rat on the grip strength meter, dragging the rat, reading the value, and measuring three times to obtain the average value.

[0093] 6. Results

[0094] 1) General condition of rats

[0095] The rats in the normal group had increased body weight, normal mental state, and smooth hair; compared with the normal group, the rats in the model control group had decreased body weight, poor mental state, decreased activity, dry hair, and hair that easily fell out when combed; compared with the model control group, the rats in the drug-treated groups did not show a significant decrease in body weight, but had improved mental state, increased activity, and reduced hair shedding. Among them, the rats in drug-treated groups 1 to 3 had the best mental state, were more active than those in drug-treated groups 4 to 8, had shiny hair, and shed the least hair.

[0096] 2) The body weight of rats is shown in Table 1. The second column of indicators for the normal group is the weight before administration, and the others are the weight after modeling.

[0097] Table 1 Comparison of body weight growth rate in different drug groups during drug administration

[0098]

[0099] As shown in Table 1, compared with the model control group, the growth rate of the drug administration group 9 was the highest in the drug administration group at 2 weeks of drug administration, followed by drug administration group 1 and drug administration group 7. The growth rate of the drug administration group 1 was the highest in the drug administration group at 4 weeks of drug administration, followed by drug administration group 2 and drug administration group 9. At 6 weeks of drug administration, the growth rate of the drug administration group 1 was the highest, followed by drug administration group 3 and drug administration group 2. It can be seen that comparative example 12 (dosage group 9) and comparative example 10 (dosage group 7) can show better improvement effects in the early stage of 2 weeks of drug administration, but the effect is not good in the later stage. The body weight of comparative example 10 (dosage group 7) decreased after 6 weeks of drug administration.

[0100] 3) The results of rat grip strength are shown in Table 2. The second column of indicators for the normal group shows the weight before administration, and the others show the weight after modeling.

[0101] Table 2 Comparison of the improvement effect of different drug groups on rat grip strength

[0102] Group Before modeling / N After modeling / before drug administration / N 6 weeks / N growth rate / % Normal group 7.35 7.51 7.65 1.86 Model control group 7.33 3.91 3.64 -6.79 Treatment group 1 6.98 3.59 5.51 53.41 Treatment group 2 7.12 3.86 5.72 48.15 Treatment group 3 7.48 4.03 5.53 37.29 Treatment group 4 7.24 3.77 4.71 25.03 Treatment group 5 7.06 3.64 4.77 31.00 Treatment group 6 7.35 3.89 4.95 27.26 Treatment group 7 7.16 3.82 4.64 21.49 Treatment group 8 7.19 3.75 5.65 50.53 Treatment group 9 7.24 3.99 5.88 47.48

[0103] As can be seen from Table 2, compared with the model control group, the gripping strength of rats in drug-treated groups 1 to 9 was improved to varying degrees, among which the gripping strength of rats in drug-treated group 1 was the best. It can be seen that the Chinese medicine compositions provided in Examples 4 to 6 can improve the gripping strength of rats in the Qi and Yin deficiency syndrome model, and have a significant effect on Qi and Yin deficiency syndrome.

[0104] According to the above animal experiments, it can be seen that the Chinese medicine composition provided by the present invention has a certain improvement effect on the Qi and Yin deficiency syndrome of the Qi and Yin deficiency syndrome model rats.

[0105] Clinical Cases

[0106] 1. Case Source: This formula was clinically validated in 80 cases from January 2021 to December 2024. Symptoms were compared before and after treatment, showing improvement in 76 cases, for an effective rate of 95%. The following case studies demonstrate the formula's efficacy using 18 volunteers who participated in the clinical validation between January 2021 and December 2024. The volunteers were diagnosed with Qi and Yin deficiency syndrome by Traditional Chinese Medicine (TCM), including three patients each of six types of Qi and Yin deficiency syndrome: palpitations, chest pain, depression, insomnia, cough, and asthenia.

[0107] 2. Diagnostic criteria

[0108] (1) Palpitations

[0109] Diagnostic criteria for TCM syndromes: formulated with reference to the "Guiding Principles for Clinical Research of New Chinese Medicines", "Diagnosis and Efficacy Criteria for TCM Internal Medicine Diseases", and the "13th Five-Year Plan" textbook for higher education in the national TCM industry, "Internal Medicine of Traditional Chinese Medicine", as follows:

[0110] 1) Main symptoms: palpitations and uneasiness in the heart.

[0111] 2) Secondary symptoms: ① fatigue, shortness of breath, especially when moving, ② chest tightness, ③ dizziness, ④ spontaneous sweating and night sweats, ⑤ fever in the five parts of the body, ⑥ dry mouth, ⑦ insomnia.

[0112] 3) Tongue and pulse: The tongue is reddish, with little or no tongue coating, and the pulse is thin, weak, deep, or rapid.

[0113] Patients with the main symptoms and two or more secondary symptoms can be diagnosed with Qi and Yin deficiency syndrome based on tongue and pulse.

[0114] (2) Chest paralysis

[0115] TCM Syndrome Diagnostic Criteria: Developed with reference to the "TCM Clinical Diagnosis and Treatment Terminology: Syndrome Section", "TCM Diagnosis and Treatment Guidelines for Chest Bi and Heart Pain", "TCM Disease and Syndrome Diagnosis and Efficacy Criteria", and "Guiding Principles for Clinical Research of New Chinese Medicines", the details are as follows:

[0116] 1) Main symptoms: chest tightness and chest pain.

[0117] 2) Secondary symptoms: palpitations and shortness of breath, which worsens with movement, fatigue, low voice, insomnia, dreaminess, spontaneous sweating, and night sweats.

[0118] 3) Tongue and pulse: The tongue is pale red, with a thin white coating, and the pulse is weak or thready.

[0119] If the patient has one of the main symptoms of chest pain or chest tightness, and two or more secondary symptoms, combined with the tongue and pulse, it can be diagnosed as qi and yin deficiency syndrome.

[0120] (3) Depression

[0121] Diagnosis of TCM Syndrome: This is formulated with reference to the "TCM Syndrome Diagnosis and Treatment Criteria" and the "TCM Syndrome Diagnosis Criteria and Treatment Plan for Depression," as follows:

[0122] 4) Main symptoms: ① Depression, ② Fatigue, ③ Insomnia and dreaminess, ④ Palpitations.

[0123] 5) Secondary symptoms: ① Suspicion and fear, ② Loss of appetite, ③ Dizziness, ④ Prone sweating, ⑤ Forgetfulness, ⑥ Dry mouth and throat.

[0124] 6) Tongue and pulse: The tongue is pale pink or red, the tongue coating is thin white and less moist, and the pulse is thin or deep and fine.

[0125] The patient should have at least 2 of the main symptoms ① and ②-④, and at least 2 of the secondary symptoms. Combined with the tongue and pulse, the patient can be diagnosed with Qi and Yin deficiency syndrome.

[0126] (4) Insomnia

[0127] Diagnostic criteria for TCM syndromes: formulated with reference to the Guiding Principles for Clinical Research of New Chinese Medicines, as follows:

[0128] 1) Main symptoms: insomnia or frequent dreams and easy awakening.

[0129] 2) Secondary symptoms: ① fatigue, ② dizziness and tinnitus, ③ dry mouth and throat, ④ hot hands and feet, ⑤ palpitations, ⑥ forgetfulness, ⑦ irritability.

[0130] 3) Tongue and pulse: Red tongue or red tip of tongue, little coating, weak or thready pulse.

[0131] Patients with three or more main and secondary symptoms can be diagnosed with Qi and Yin deficiency syndrome based on tongue and pulse.

[0132] (5) Cough

[0133] Diagnostic criteria for TCM syndromes: These criteria were developed with reference to the "Expert Consensus on TCM Diagnosis and Treatment of Cough," the "Guiding Principles for Clinical Research of New Chinese Medicine Drugs," and the "Guidelines for TCM Diagnosis and Treatment of Acute Tracheobronchitis," and are as follows:

[0134] 1) Main symptom: cough.

[0135] 2) Secondary symptoms: little sputum or dry cough; chest tightness and shortness of breath; fatigue; aversion to wind or susceptibility to colds; spontaneous sweating or night sweats; hot palms and soles; dry mouth and throat.

[0136] 3) Tongue and pulse: pale or red tongue with little coating, weak or thready pulse.

[0137] Patients with two or more main and secondary symptoms can be diagnosed with Qi and Yin deficiency syndrome based on tongue and pulse.

[0138] (6) Asthenia

[0139] TCM Syndrome Diagnostic Criteria: This was developed with reference to the Clinical Research Guidelines for New Chinese Medicines for the Treatment of Chronic Fatigue Syndrome, the National TCM Higher Education "Thirteenth Five-Year Plan" textbook "Chinese Medicine Internal Medicine," and the TCM Clinical Diagnosis and Treatment Terminology - Syndrome Section. These are as follows:

[0140] 1) Main symptoms: ① Fatigue, aggravated by exertion, ② Spontaneous sweating and shortness of breath, ③ Dizziness, ④ Palpitations and insomnia, ⑤ Back pain, dull pain in joints and muscles, ⑥ Dry throat and mouth.

[0141] 2) Secondary symptoms: hot flashes, sweating, fever in the five hearts, poor appetite, nocturnal emission, spermatorrhea or menstrual disorders, dry and hard stools, and scanty urination.

[0142] 3) Tongue and pulse: red tongue with little coating and thready and rapid pulse.

[0143] Patients with two or more main symptoms and two or more secondary symptoms can be diagnosed with Qi and Yin deficiency syndrome based on tongue and pulse.

[0144] 3. Clinical case effect evaluation

[0145] According to the specific conditions of each type of patients with Qi and Yin deficiency syndrome, a Chinese medicine composition within the formula range of the Chinese medicine composition provided by the present invention is selected. The specific conditions of the cases and medication are as follows.

[0146] 1) Palpitations due to Qi and Yin deficiency syndrome

[0147] Case 1, female, 52 years old, chief complaint: recurrent palpitations and shortness of breath for 3 months, aggravated and accompanied by general fatigue for 1 week. Current medical history: 3 months ago, the patient developed palpitations and shortness of breath after working late for a long time. An electrocardiogram at an external hospital showed frequent atrial premature beats (no report was found). She was given oral "Shensong Yangxin Capsule" for treatment, and the symptoms were slightly relieved. Since then, the above symptoms have recurred. In the past week, the above symptoms have worsened due to fatigue, accompanied by general fatigue, and she came to the clinic. Current symptoms: palpitations, shortness of breath, accompanied by general fatigue, lasting 10 minutes, relieved after rest. No nasal congestion, runny nose, no intolerance to cold or heat, no abdominal pain, diarrhea, dry mouth, no bitter taste in the mouth, hot palms and soles, no night sweats. She is prone to getting angry and prone to oral ulcers. Appetite is good, but sleep is poor, difficulty falling asleep, dreaming, can sleep for 5 hours per night, and does not feel refreshed after waking up. Bowel movements are normal. Tongue is red, with little coating, and pulse is thin and weak. The prescription consists of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Tortoise Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 6g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction is taken once a day for 14 doses. Symptoms after use include relief of palpitations and shortness of breath, decreased frequency of attacks, and duration of attacks reduced to approximately 5 minutes. Fatigue, hot palms and soles, night sweats, and dry mouth are reduced. Sleep duration is increased to 6-7 hours.

[0148] Case 2, male, 44 years old, chief complaint: palpitations for 1 week. Current medical history: The patient developed palpitations after catching a cold 1 week ago, with intermittent attacks, which worsened when lying down and after exertion, and came to the clinic. Current symptoms: palpitations, with attacks lasting from a few minutes to a few hours. No chest tightness, chest pain, shortness of breath, no dizziness, no nausea or vomiting, dry mouth, heavy sweating, which comes out with the slightest movement. Appetite is good, he usually likes to eat spicy and irritating food, has poor sleep, has difficulty falling asleep, has frequent dreams and wakes up easily, and his bowel movements are normal. Red tongue, thin fur, and thready pulse. Auxiliary examinations: Electrocardiogram: sinus rhythm, heart rate 70 beats / min; frequent ventricular premature beats. The prescription uses 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Tortoise Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici nucifera, 9g of Dry Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 20g of Jujube. Decoction in water is taken once daily for 7 doses. Symptoms after use include a significant reduction in premature beats, improved sweating and sleep, and a reduction in dry mouth.

[0149] Case 3, male, 56 years old, chief complaint: palpitations for 1 week, aggravated for 1 day. The patient experienced palpitations after drinking alcohol 1 week ago, each attack lasted 3-5 seconds, relieved after rest, and was not taken seriously. 1 day ago, the palpitations worsened, accompanied by dizziness and fatigue, and he came to the clinic. Current symptoms: palpitations, uncontrolled heartbeat during the attack, which lasted for several minutes and stopped with sweating, dizziness, and fatigue. No chest pain, nausea, or vomiting. Dry and bitter mouth in the morning, thirst not quenched by drinking, obvious sweating on the head at night. Average appetite, poor sleep, easy awakening 3 times / night, difficulty falling asleep after waking up. Stool slightly dry, normal urination. Red tongue, thin fur, thready pulse. The prescription consists of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 9g of Dry Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction is taken once a day for 14 doses. Symptoms after treatment: Recently, the frequency of palpitations accompanied by dizziness and fatigue has decreased, dry mouth has eased, nighttime sweating has decreased, sleep has improved, the number of awakenings has decreased to once per night, and the patient can fall asleep again after waking. Bowel movements are normal, and flatulence has disappeared.

[0150] 2) Chest pain due to deficiency of both Qi and Yin

[0151] Case 1, male, 62 years old, chief complaint: pain in the precordial area after activities for more than a month, aggravated for a week. Current medical history: pain in the precordial area after activities appeared more than a month ago, lasting for several minutes and relieved after rest, and relevant examinations were performed at another hospital. Symptoms worsened after exertion 1 week ago, and the frequency of pain increased, so he came to the clinic. Current symptoms: pain in the precordial area, aggravated by exertion. Stomach bloating, fatigue, tiredness and laziness, usually dry mouth, no bitter taste in the mouth, slightly more sweating, especially on the head. Good appetite, normal sleep, frequent dreams, regular bowel movements. Pale red tongue, thin fur, weak pulse. Auxiliary examinations: Cardiac ultrasound showed: degenerative lesions of the aortic valve; decreased left ventricular diastolic function. Coronary CTA showed: 1. Mixed plaques in the left coronary artery (LM) trunk, with mild stenosis of the lumen. 2. Calcified and mixed plaques in the proximal segment of the descending anterior artery (LAD), with moderate to severe localized luminal stenosis. 3. Calcified plaques in the proximal segment of the diagonal branch (D1), with mild luminal stenosis. 4. Scattered calcified, mixed, and soft plaques in the circumflex artery (LCx), with moderate localized luminal stenosis in the proximal segment and severe localized luminal stenosis in the mid- and distal segments. 5. Scattered mixed and soft plaques in the main trunk of the right coronary artery (RCA), with severe localized luminal stenosis. Please combine clinical and DSA examinations. The electrocardiogram shows sinus bradycardia (heart rate 53 bpm). The prescription is: Ophiopogon japonicus 70g, Red Ginseng 10g, Dipsacus asper 20g, Cornus officinalis 20g, Vinegar-soaked Tortoise Shell 21g, Pinellia ternata 9g, Citrus aurantium 10g, Ligusticum chuanxiong 12g, Dried Ginger 6g, Cinnamomum cassia twig 10g, Licorice root 10g, and Jujube 20g. Decoction in water, one dose daily for 21 doses. Symptoms after medication: Precordial pain significantly improved, dry mouth and fatigue alleviated, stomach bloating basically disappeared, fatigue alleviated, head sweating decreased compared to before, and sleep was good at night. Repeated electrocardiogram showed: sinus rhythm, heart rate 65 beats / min.

[0152] Case 2, female, 56 years old, chief complaint: chest tightness and shortness of breath for 1 year, aggravated for 1 week. Current medical history: Sudden onset of persistent chest tightness 1 year ago, hospitalized at a local hospital, diagnosed with "coronary heart disease", and later transferred to a higher-level hospital for "coronary angiography + drug-eluting balloon angioplasty" (specific blood vessels and lesions unknown). Postoperatively, she took regular medications such as "ticagrelor tablets and atorvastatin calcium tablets". Since then, the symptoms have intermittently occurred after fatigue or anger. 1 week ago, the symptoms worsened after fatigue, lasting for about a few minutes and relieved after rest. Presented for consultation. Current symptoms: chest tightness and shortness of breath, lasting about 10 minutes, relieved after rest, and more pronounced after fatigue or anger. Palpitations, dry mouth, bitter taste, burning sensation in the chest, more pronounced at night, preference for drinking water, dry mouth that does not subside after drinking water. Appetite is good, sleep is poor, and there are frequent dreams. Bowel movements are normal. Tongue is red, with a red tip, a thin white coating, and a thready pulse. The prescription consists of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 9g of Dry Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 20g of Jujube. Decoction is taken once a day for 14 doses. Symptoms after use: Chest tightness and palpitations have largely disappeared, but they occur after exertion or emotional excitement. Dryness, bitter taste in the mouth, and the burning sensation in the chest at night have been significantly alleviated. Sleep has improved, and the frequency of dreams has decreased.

[0153] Case 3, female, 64 years old, chief complaint: intermittent chest pain for 3 months. Current medical history: The patient developed chest pain, chest tightness and shortness of breath after being tired due to something at home 3 months ago, accompanied by palpitations, sweating, and fatigue. The symptoms were relieved after resting for 3-4 minutes, but she did not pay attention to it. In January, the above symptoms appeared after fatigue and she visited a local hospital. PCI treatment was recommended, but the patient refused. She now comes to the hospital for further treatment. Current symptoms: chest pain, chest tightness and shortness of breath, which gradually subside after rest and belching, dry mouth and bitter taste in the mouth in the morning, excessive sweating, night sweats, decreased appetite compared to before, poor sleep, easy awakening, and regular bowel movements. The tongue is red, with a thin white coating and a thready pulse. Auxiliary examinations: Coronary CTA: The left anterior descending coronary artery is stiff, with a stenosis of approximately 60%-80% at the narrowest point. The prescription consists of 60g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 6g of Dry Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction in water is taken once a day for 14 doses. Symptoms after use include significant relief of chest pain, chest tightness, shortness of breath, palpitations, sweating, and fatigue; relief of dry and bitter mouth; reduced night sweats; improved appetite; and fewer awakenings.

[0154] 3) Depression due to deficiency of both Qi and Yin

[0155] Case 1, female, 43 years old, chief complaint: depression and anxiety for more than half a year, aggravated for 1 week. Current medical history: More than half a year ago, the patient developed depression and anxiety after some test results were found to be abnormal during a physical examination. She felt chest tightness and irritability. She visited the local hospital for many times and was diagnosed with "depression". She was treated with oral medication (specific details are unknown), but the effect was poor. The above symptoms worsened 1 week ago and she came to the clinic. Current symptoms: depression, anxiety, chest tightness, shortness of breath, and irritability. Easily nervous, frightened, dry mouth in the morning, sweaty palms, poor sleep, difficulty falling asleep, easy to wake up and dreamy. Dry stool, normal urination. Red tongue, thin white fur, deep and thin pulse. The prescription consisted of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction was taken once daily for 10 doses. Symptoms after treatment included: Overall mood improved, and symptoms of chest tightness, shortness of breath, and palpitations were significantly alleviated. Dry mouth was relieved, hand sweating decreased, sleep onset was slightly faster, and bowel movements were normal.

[0156] Case 2, a 38-year-old male, presented with chief complaints of depression accompanied by palpitations and insomnia for one month. Over a month ago, the patient developed depression due to stressful family events, gradually experiencing palpitations and insomnia, leading to his consultation. Current symptoms: depression, melancholy, and palpitations. Insomnia, waking at 4 a.m. and difficulty falling asleep. Dry mouth and thirst, unsatisfactory drinking, irritability, and anxiety and tension. Fatigue, soreness in the lower back and knees, and poor appetite. Dry stools, with normal urination. Red tongue with a thin coating and a thready pulse. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction in water, one dose daily for 14 doses. Symptoms after medication: Mood has significantly improved, palpitations have decreased, sleep has improved, and sleep quality has improved. Although I still wake up at 4 a.m., I can fall asleep again after waking. Dry mouth, fatigue, and soreness in the waist and knees have been alleviated, and irritability has basically disappeared.

[0157] Case 3, a 19-year-old female, presented with chief complaints of depression and restlessness for a year, which worsened over the past month. A year ago, depression and restlessness developed due to academic pressure, but were not addressed or treated. A month ago, after her grades declined, her symptoms gradually worsened, accompanied by chest tightness, restlessness, and insomnia, prompting her to seek medical attention. Current symptoms included depression, restlessness, chest tightness, restlessness, poor concentration, a lack of interest in anything, and a reluctance to socialize. She also presented with noticeable sweating in her palms, irritability, loss of appetite, insomnia, frequent dreams, dry stools, and normal urination. Her tongue was red with a thin white coating and a thready pulse. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 6g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. The decoction was taken three times daily for a total of 14 doses. Symptoms after medication: Mood and spirit improved significantly, able to try socializing a little, chest tightness and irritability relieved, attention more focused than before, hand sweating slightly reduced, sleep quality improved, bowel movements normal.

[0158] 4) Insomnia due to Qi and Yin deficiency

[0159] Case 1, male, 48 years old, chief complaint: insomnia for over a year, aggravated for a month. Current medical history: Over a year ago, the patient developed insomnia and difficulty falling asleep, requiring oral estazolam to help with sleep. One month ago, the insomnia symptoms worsened, and estazolam was ineffective, leading to his consultation. Current symptoms: insomnia, difficulty falling asleep, sleeping 3-4 hours a night, sometimes all night, tossing and turning. Palpitations, hot flashes, sweating, soreness in the waist and knees, and easy irritability. Appetite is good, stools are dry and hard, 2-3 times a day, and urination is normal. The tongue is red, with a red tip, a scant coating, and a thready pulse. The prescription consists of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici amomi, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction in water, once daily for 14 doses. Symptoms after treatment: Insomnia symptoms have significantly improved. Estazolam has now been discontinued and sleep is now 4-5 hours per night. Palpitations, hot flashes, and sweating have decreased, lower back and knee soreness has improved, and mood has stabilized. Constipation has improved and is now normal, with daily bowel movements.

[0160] Case 2, a 59-year-old male, presented with complaints of poor sleep and frequent awakenings for two years. Presenting medical history: Two years prior, the patient developed poor sleep and frequent awakenings. He had sought treatment from various Chinese and Western medicine clinics with limited success, and presented for consultation. Current symptoms: poor sleep and frequent awakenings, waking between 1 and 3 a.m., and difficulty falling asleep again. He was heat-averse, with sweating in his palms and soles, shortness of breath after running or climbing stairs, and daytime fatigue, palpitations, and shortness of breath. He also experienced dry mouth and tongue. His appetite was normal, and his bowel movements were normal. His tongue was red, with a red tip and scant coating, and his pulse was thready and rapid. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction was taken once daily for 14 doses. Symptoms after medication: Sleep is significantly improved, able to fall asleep after waking up, heat intolerance is reduced, sweating of the palms and soles is significantly reduced, mental state is improved compared to before, shortness of breath symptoms after activities are basically gone, daytime palpitations and shortness of breath are reduced, and dry mouth and tongue are relieved.

[0161] Case 3, female, 53 years old, chief complaint: insomnia for more than 2 years, aggravated with night sweats for 1 year. Current medical history: 2 years ago, the patient developed insomnia, frequently woke up at night, could only sleep for 2-3 hours every night, affecting the daytime mental state, dizziness and headache in severe cases, but did not pay attention to or receive treatment. In the past year, the patient's insomnia worsened with night sweats all over the body. She visited many places for combined Chinese and Western medicine treatment, but the effect was not obvious, so she came to the clinic. Current symptoms: poor sleep, frequent awakenings at night, could only sleep for 2-3 hours every night, accompanied by whole body sweats, soaking clothes and quilts, occasional dizziness and headaches. Poor daytime mental state, fatigue, dry mouth, fear of heat, poor appetite, like spicy food, dry stool, 1-2 times a day, normal urination. Red tongue, little coating, thin pulse. The prescription consisted of 70g of Radix Ophiopogonis, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Rhizoma Ligustici Nuciferae, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. The decoction was taken once daily for seven doses. Symptoms after treatment: The patient's insomnia improved significantly, with fewer nighttime awakenings and a stable sleep of 4-5 hours per night. Perspiration decreased significantly, and dizziness and headaches disappeared. His daytime mental state improved significantly, fatigue decreased, dry mouth and heat intolerance eased, appetite increased, bowel movements returned to normal, and urination became normal.

[0162] 5) Cough due to Qi and Yin deficiency

[0163] Case 1, a 62-year-old female, presented with a chief complaint of cough and sputum for one month. Her current medical history: A month ago, she developed cough and sputum after catching a cold. Treatment with a combination of traditional Chinese and Western medicine alleviated her symptoms, but she now presents with frequent coughs, producing small, sticky, white sputum, and an itchy throat. She also experienced dry mouth, back pain, fatigue, frequent colds, occasional night sweats, poor appetite, and normal sleep. Her bowel movements were normal. Her tongue was red with a thin coating, and her pulse was weak. Her medical history included chronic bronchitis and chronic pharyngitis. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 20g of Jujube. The decoction was taken once daily for 14 doses. Symptoms after medication: The frequency of coughing and expectoration decreased, throat itching basically disappeared, dry mouth was alleviated, mental state was better than before, and night sweats did not occur during the medication period.

[0164] Case 2, a 25-year-old male, presented with a chief complaint of recurrent cough for six months. His current medical history: Six months prior, he developed a cough after a cold and fever, and the symptoms persisted. He visited a local hospital for a lung CT scan, which showed no significant abnormalities. He was given oral Chinese medicine to clear heat and detoxify, relieve cough, and resolve phlegm, as well as antibiotics, but these treatments were ineffective. He subsequently presented for treatment. His current symptoms included a cough that was worse at night, disrupting his sleep, an itchy throat, and difficulty coughing up phlegm. He sweated profusely, even with the slightest movement. His appetite was good, but he fell asleep late. His stools were dry, and his urination was normal. His tongue was red, slightly urinary, and his pulse was weak. The patient was given a decoction of Ophiopogon japonicus 70g, Red Ginseng 10g, Dipsacus asper 20g, Cornus officinalis 20g, Turtle Shell in Vinegar 10g, Pinellia ternata 9g, Citrus aurantium 10g, Rhizoma Ligustici amara 12g, Dried Ginger 6g, Cinnamomum cassia twig 10g, Licorice root 10g, and Jujube 10g. The decoction was administered once daily for seven doses. Symptoms after medication: cough and itchy throat symptoms are alleviated, sputum is easier to cough up than before, sweating is slightly less than before, and dry stool is improved.

[0165] Case 3, a 51-year-old female, presented with a chief complaint of coughing for over 10 years, which worsened for six months. Current medical history: The cough had been present for over 10 years, with onset every winter and improvement in spring. It has worsened in the past six months, with the cough returning in autumn. She visited a local hospital and was diagnosed with chronic bronchitis. Western medication was given, but the results were ineffective, prompting her to seek medical attention. Current symptoms include cough, itchy throat, and white, sticky phlegm. She suffers from frequent fatigue, slight chest tightness, night sweats that soak clothing, a good appetite, poor sleep, difficulty falling asleep, frequent dreams, and frequent awakenings. Her bowel movements were normal. Her tongue was red with scanty coating, and her pulse was thready and weak. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 6g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction in water was administered once daily for 21 doses. Symptoms after medication: cough and itchy throat symptoms are relieved, white sticky sputum is reduced, fatigue is improved, the number of night sweats is reduced, and sleep is improved.

[0166] 6) Consumption due to deficiency of both Qi and Yin

[0167] Case 1, a 54-year-old male, presented with chief complaints of fatigue and shortness of breath for six years. Current medical history: Six years ago, the patient developed fatigue and shortness of breath without apparent cause. He had been treated with a combination of traditional Chinese and Western medicine (unspecified) at other hospitals, but with limited success, and presented for consultation. Current symptoms: fatigue, shortness of breath after activity, and difficulty breathing. He experienced significant hair loss, no intolerance to cold, profuse sweating, dry mouth with a slight bitter taste, no dry throat, and a generally normal mood. His appetite was good, but his sleep was poor, with difficulty falling asleep. He had 3-4 bowel movements daily and normal urination. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. The decoction was taken once daily for ten doses. Symptoms after medication: Fatigue and shortness of breath are significantly relieved, sweating is reduced, dry mouth and bitter taste in the mouth are relieved, sleep is improved, and falling asleep is faster than before.

[0168] Case 2, a 46-year-old male, presented with chief complaints of general fatigue for three years, which worsened with poor sleep, dizziness, and tinnitus for six months. Current medical history: Three years ago, the patient developed general fatigue without apparent cause, but ignored it and received no treatment. Six months ago, after staying up late for an extended period, he developed dizziness, tinnitus, and poor sleep, and presented for consultation. Current symptoms: general fatigue, dizziness, tinnitus, soreness in the waist and knees, poor sleep quality, frequent dreams and easy awakenings, daytime drowsiness, and difficulty concentrating. Poor appetite, slightly dry stools, and normal urination. The prescription consisted of 60g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 20g of Jujube. Decoction was taken once daily for 14 doses. Symptoms after medication: Overall mental state is better than before, fatigue is significantly reduced, dizziness and tinnitus are basically gone, soreness in the waist and knees is reduced, sleep quality is improved, appetite is normal, and bowel movements are normal.

[0169] Case 3, a 35-year-old male, presented with chief complaints of fatigue and drowsiness for three years, which worsened over the past week. Current medical history: Three years ago, the patient developed fatigue and drowsiness after frequent late nights, which improved slightly with rest, but he received no treatment. A week ago, fatigue and drowsiness worsened after work, leading him to seek medical attention. Current symptoms: fatigue and drowsiness, mental fatigue, palpitations, slight chest tightness, shortness of breath with movement, dry mouth, lower back and knee pain, poor appetite, poor sleep, difficulty falling asleep, slightly dry stools, and normal urination. His tongue was red with a scant coating, and his pulse was thready. The prescription consisted of 70g of Ophiopogon japonicus, 10g of Red Ginseng, 20g of Dipsacus asper, 20g of Cornus officinalis with wine, 10g of Turtle Shell with vinegar, 9g of Pinellia ternata with ginger, 10g of Citrus aurantium immaturus, 12g of Ligusticum wallichii, 9g of Dried Ginger, 10g of Cinnamomum cassia, 10g of Licorice root, and 10g of Jujube. Decoction was taken once daily for 14 doses. Symptoms after medication: fatigue, shortness of breath after movement, palpitations and chest tightness improved, mental state is better than before, dry mouth is relieved, slight waist and knee pain, appetite is normal, sleep quality improved, falling asleep faster than before, bowel movements are normal, 1 time / day.

[0170] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A traditional Chinese medicine composition for treating qi and yin deficiency syndrome, comprising the following components: 60-70g of ophiopogon japonicus, 7-15g of red ginseng, 15-20g of dipspermum officinale, 15-20g of cornus officinalis with wine, 10-20g of tortoise shell with vinegar, 7-15g of pinellia ternata with ginger, 10-18g of immature bitter orange, 10-15g of northern liujiu, 4-10g of dried ginger, 7-15g of cassia twig, 7-15g of liquorice, and 10-20g of jujube.

2. The Chinese medicine composition according to claim 1, characterized in that It includes the following components: 63g of Ophiopogon japonicus, 9g of red ginseng, 18g of Dipsacus asper, 18g of Cornus officinalis with wine, 18g of tortoise shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Northern Liujienu, 6g of dried ginger, 9g of cinnamon twig, 9g of liquorice, and 15g of jujube.

3. A traditional Chinese medicine extract for treating qi and yin deficiency syndrome, which is extracted from traditional Chinese medicine raw materials, wherein the traditional Chinese medicine raw materials include the following components: 60-70g of Ophiopogon japonicus, 7-15g of Red Ginseng, 15-20g of Dipsacus asper, 15-20g of Cornus officinalis with wine, 10-20g of Tortoise Shell with vinegar, 7-15g of Pinellia ternata with ginger, 10-18g of Citrus aurantium, 10-15g of Northern Liuji Nu, 4-10g of dried ginger, 7-15g of cinnamon twig, 7-15g of liquorice, and 10-20g of jujube.

4. The Chinese medicine extract according to claim 3, characterized in that The Chinese medicinal raw materials include the following components: 63g of Ophiopogon japonicus, 9g of red ginseng, 18g of Dipsacus asper, 18g of cornus fruit with wine, 18g of tortoise shell with vinegar, 9g of Pinellia ternata with ginger, 15g of Citrus aurantium, 12g of Ligusticum wallichii, 6g of dried ginger, 9g of cassia twig, 9g of liquorice, and 15g of jujube.

5. A Chinese medicine preparation for treating Qi and Yin deficiency syndrome, characterized in that: The invention comprises the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine extract according to claim 3 or 4.

6. The Chinese medicine preparation according to claim 5, characterized in that The dosage form of the traditional Chinese medicine preparation includes at least one of pills, decoctions, tablets, powders, pastes, granules, mixtures, oral liquids or capsules.

7. Use of the Chinese medicine composition according to claim 1 or 2, the Chinese medicine extract according to claim 3 or 4, or the Chinese medicine preparation according to claim 5 or 6 in preparing a medicine for treating Qi and Yin deficiency syndrome.

8. The use according to claim 7, characterized in that The Qi and Yin deficiency syndrome includes Qi and Yin deficiency diseases of the heart and lungs.

9. The use according to claim 8, characterized in that The heart and lung qi and yin deficiency diseases include at least one of qi and yin deficiency syndromes of palpitations, chest pain, depression, insomnia, cough and asthenia.

10. Use of the Chinese medicine composition according to claim 1 or 2, the Chinese medicine extract according to claim 3 or 4, or the Chinese medicine preparation according to claim 5 or 6 in the preparation of any of the following medicines: A1. Medications for treating palpitations; A2. Drugs for treating chest pain; A3. Medications for treating depression; A4. Medications for treating insomnia; A5. Medicines for treating cough; A6. Medicines for treating asthenia.

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