Blood cell analyzer and blood cell analysis method

Abstract

The application discloses a blood cell analyzer and a blood cell analysis method. The liquid storage assembly of the blood cell analyzer comprises a liquid storage cavity. The height of the inlet of the liquid storage cavity is less than the height of the outlet. The first end of the temporary storage mechanism of the liquid path emptying assembly is connected with the pressure supply mechanism. The second end of the temporary storage mechanism is connected with the inlet of the liquid storage assembly through the first control valve. The processor is used to control the pressure supply mechanism to switch the temporary storage mechanism to the negative pressure state in response to receiving the liquid draining instruction. The processor is also used to control the first control valve to conduct the liquid storage assembly and the temporary storage mechanism, so that the liquid in the liquid storage cavity is drained through the pipeline between the first control valve and the liquid storage assembly. The liquid in the liquid storage cavity can be drained through the pipeline between the first control valve and the liquid storage assembly by the temporary storage mechanism in the negative pressure state, the residual reagent in the liquid storage cavity is removed, the blockage failure caused by the evaporation and crystallization of the reagent is reduced or avoided, and the service life and reliability of the blood cell analyzer are improved.

Description

Technical Field

[0001] This application relates to the field of in vitro diagnostic technology, and in particular to blood cell analyzers and blood cell analysis methods. Background Technology

[0002] In blood cell analyzers, to better remove air bubbles present in the reagents, some liquid storage components have a bottom-in, top-out liquid path structure for the liquid to flow through, allowing the liquid to flow from bottom to top to another component, thereby reducing the impact of air bubbles on the analyzer's detection.

[0003] However, when the liquid storage assembly adopts a bottom-in, top-out structure, because the outlet level of the liquid in the storage chamber is higher than the inlet level, when the liquid in the storage chamber is discharged from its outlet, some reagent remains at the bottom of the storage chamber. When the reagent remains in the chamber for too long, the water in the reagent will gradually evaporate and crystallize. Crystallization can easily cause blockage of the chamber, flow channel and liquid circuit valve device, resulting in a decrease in the reliability of the blood cell analyzer. Summary of the Invention

[0004] To address the aforementioned technical problems, this application provides a blood cell analyzer and a blood cell analysis method.

[0005] To address the aforementioned problems, this application provides a blood cell analyzer, including a liquid storage component, a liquid drainage component, and a processor. The liquid storage component includes a liquid storage chamber with an inlet and an outlet, the height of which is less than the height of the outlet. The liquid drainage component includes a temporary storage mechanism, a pressure supply mechanism, and a first control valve. A first end of the temporary storage mechanism is connected to the pressure supply mechanism via a pipeline, and a second end of the temporary storage mechanism is connected to the inlet of the liquid storage component via the first control valve. The processor is connected to the liquid drainage component. In response to receiving a drainage command, the processor controls the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state. The processor also controls the first control valve to open the liquid storage component and the temporary storage mechanism, so that the liquid in the liquid storage chamber is discharged through the pipeline between the first control valve and the liquid storage component.

[0006] Optionally, the blood cell analyzer further includes a liquid collection component connected to the outlet of the liquid storage component; the processor is configured to: in response to receiving the discharge command, control the first control valve to open the liquid storage component and the temporary storage mechanism, and first control the pressure supply mechanism to switch the temporary storage mechanism to a positive pressure state so that the liquid in the liquid storage chamber is discharged to the liquid collection component through the outlet; then control the first control valve to open the liquid storage component and the temporary storage mechanism, and control the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state so that the liquid in the liquid storage chamber is discharged through the pipeline between the inlet, the first control valve and the liquid storage component.

[0007] Optionally, the blood cell analyzer includes a reagent supply component, the temporary storage mechanism includes a power pump, the first end of the first control valve is connected to the power pump via the pipeline, the second end of the first control valve is connected to the reagent supply component via the pipeline, and the third end of the first control valve is connected to the liquid storage component via the pipeline; wherein, the processor is configured to: in response to receiving the discharge command, control the pressure supply mechanism to switch the power pump to the negative pressure state; control the first control valve to open the power pump and the liquid storage component, so that the power pump draws liquid from the pipeline between the liquid storage chamber and the first control valve; control the pressure supply mechanism to switch the power pump to the positive pressure state, and control the first control valve to open the power pump and the reagent supply component, so that the power pump discharges the drawn liquid to the reagent supply component.

[0008] Optionally, the reagent supply assembly is used to provide a first reagent; before the power pump draws liquid from the pipeline between the liquid storage chamber and the first control valve, the processor is further used to: control the first control valve to connect the power pump and the reagent supply assembly, and control the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state, so that the power pump draws the first reagent from the reagent supply assembly; control the first control valve to connect the power pump and the liquid storage assembly, and control the pressure supply mechanism to switch the temporary storage mechanism to a positive pressure state, so that the power pump discharges the drawn first reagent to the liquid storage assembly to clean the liquid storage assembly.

[0009] Optionally, the blood cell analyzer further includes an incubation component, the reagent supply component is used to provide a second reagent, and the incubation component is connected to the outlet of the reservoir component; before the power pump draws liquid from the pipeline between the reservoir and the first control valve, the processor is further configured to: control the power pump to draw the second reagent from the reagent supply component when the first control valve is open to the power pump and the reagent supply component and the temporary storage mechanism is in the negative pressure state; control the power pump to discharge the drawn second reagent to the reservoir component when the first control valve is open to the power pump and the reservoir component and the temporary storage mechanism is in the positive pressure state, so as to replenish the reservoir component with the second reagent; and / or control the first control valve to open the reservoir component and the power pump, and control the pressure supply mechanism to switch the power pump to the positive pressure state so that the liquid in the reservoir is discharged to the incubation component through the outlet.

[0010] Optionally, the blood cell analyzer includes a reagent supply component, the temporary storage mechanism includes a storage tank, a power pump, and a second control valve, the power pump is connected to the storage tank via the second control valve, the storage tank is connected to the storage component via the first control valve, and the pressure supply mechanism is connected to the storage tank and the power pump respectively; wherein, the processor is configured to: in response to receiving the discharge command, control the pressure supply mechanism to switch the power pump to the negative pressure state, and control the second control valve to open the storage tank and the power pump, so that the power pump draws air from the storage tank; when the air pressure in the storage tank reaches a preset condition, control the first control valve to open the storage tank and the storage component, so that the liquid in the storage chamber is discharged to the storage tank through the pipeline between the inlet, the first control valve, and the storage component.

[0011] Optionally, the above-mentioned liquid drainage assembly further includes a third control valve and a drainage branch. The first end of the third control valve is connected to the pipeline between the liquid storage tank and the first control valve, and the second end of the third control valve is connected to the drainage branch. The processor is also used to control the first control valve to shut off and control the third control valve to open, so that the liquid in the liquid storage tank is discharged to the drainage branch.

[0012] Optionally, the pressure supply mechanism includes a first pressure source, a second pressure source, and a fourth control valve. The first pressure source is connected to the power pump, and the second pressure source is connected to the liquid storage tank via the fourth control valve. The second pressure source provides positive pressure to the liquid storage tank. The blood cell analyzer also includes a liquid collection assembly connected to the outlet of the liquid storage assembly. Before the liquid in the liquid storage chamber is discharged into the liquid storage tank through the pipeline between the inlet, the first control valve, and the liquid storage assembly, the processor, in response to receiving the discharge command, controls the first control valve to open the liquid storage tank. The processor controls the fourth control valve to open, so that the liquid in the liquid storage chamber is discharged to the liquid collection assembly through the outlet under the positive pressure of the second pressure source. Before the liquid in the liquid storage chamber is discharged to the liquid storage tank through the pipeline between the inlet, the first control valve and the liquid storage assembly, the processor is further configured to, in response to receiving the discharge command, control the second control valve to open the power pump and the liquid storage tank, and control the first pressure source to switch the power pump to a positive pressure state, so that the power pump discharges the drawn reagent to the liquid storage assembly to clean the liquid storage assembly.

[0013] Optionally, the above-mentioned liquid drainage assembly further includes a waste liquid storage mechanism. The first end of the second control valve is connected to the power pump through the above-mentioned pipeline, the second end of the second control valve is connected to the liquid storage tank through the above-mentioned pipeline, and the third end of the second control valve is connected to the waste liquid storage mechanism through the above-mentioned pipeline. The processor is configured to: in response to receiving the above-mentioned drainage command, first control the second pressure source to switch the power pump to a positive pressure state, and control the second control valve to connect the power pump and the waste liquid storage mechanism, so as to discharge the liquid from the power pump to the waste liquid storage mechanism. Then, the second pressure source is controlled to switch the power pump to the negative pressure state, and the second control valve is controlled to open the liquid storage tank and the power pump so that the power pump draws air from the liquid storage tank; the steps of controlling the second pressure source to switch the power pump to the positive pressure state and controlling the second control valve to open the power pump and the waste liquid storage mechanism, and controlling the second pressure source to switch the power pump to the negative pressure state and controlling the second control valve to open the liquid storage tank and the power pump are repeated until the air pressure in the liquid storage tank reaches the preset condition.

[0014] To address the aforementioned problems, this application provides a blood cell analysis method applied to the blood cell analyzer described above. The method includes: in response to receiving a drain command, switching the temporary storage mechanism to a positive pressure state; controlling a first control valve to open the liquid storage component and the temporary storage mechanism, driving reagents into the liquid storage component to clean it; controlling the liquid in the liquid storage component to drain from its outlet; switching the temporary storage mechanism to a negative pressure state; controlling the first control valve to open the liquid storage component and the temporary storage mechanism, so that the liquid in the liquid storage component is drained through the inlet of the liquid storage component, the first control valve, and the pipeline between the liquid storage component and the temporary storage mechanism.

[0015] This application provides a hematology analyzer and a hematology analysis method. The hematology analyzer's liquid storage component includes a liquid storage chamber with an inlet and an outlet, the height of which is less than the height of the outlet. A temporary storage mechanism of the liquid drainage component has a first end connected to a pressure supply mechanism via a pipeline, and a second end connected to the inlet of the liquid storage component via a first control valve. A processor, in response to receiving a drainage command, controls the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state. The processor also controls the first control valve to open the liquid storage component and the temporary storage mechanism, allowing the liquid in the liquid storage chamber to be drained through the pipeline between the first control valve and the liquid storage component. Therefore, this application can drain the liquid in the liquid storage chamber through the pipeline between the first control valve and the liquid storage component using the temporary storage mechanism under negative pressure, thereby removing residual reagents from the liquid storage chamber, reducing or avoiding blockages caused by reagent evaporation and crystallization, and improving the service life and reliability of the hematology analyzer. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0017] Figure 1 This is a schematic diagram of the structure of the first embodiment of the blood cell analyzer provided in this application;

[0018] Figure 2 This is a schematic diagram of the structure of the second embodiment of the blood cell analyzer provided in this application;

[0019] Figure 3 This is a schematic diagram of the third embodiment of the blood cell analyzer provided in this application;

[0020] Figure 4 This is a schematic diagram of the fourth embodiment of the blood cell analyzer provided in this application;

[0021] Figure 5 This is a schematic flowchart of an embodiment of the blood cell analysis method provided in this application.

[0022] Among them, 10, liquid storage assembly; 11, liquid storage chamber; 20, liquid drainage assembly; 21, temporary storage mechanism; 211, power pump; 212, liquid storage tank; 213, second control valve; 22, pressure supply mechanism; 221, fifth control valve; 222, first pressure source; 2221, positive pressure source; 2222, negative pressure source; 223, second pressure source; 224, fourth control valve; 23, first control valve; 24, third control valve; 25, drain branch; 26, waste liquid storage mechanism; 27, sixth control valve; 30, processor; 40, liquid collection assembly; 50, reagent supply assembly; 51, first storage bottle; 52, second storage bottle; 53, third storage bottle; 60, incubation assembly. Detailed Implementation

[0023] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0024] It should be noted that if the embodiments of this application involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicators will also change accordingly.

[0025] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, features defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0026] Specifically, in one embodiment of the related technology, in order to ensure the accuracy and reliability of the detection, the blood cell analyzer may include a reagent preheating component, which is used to preheat the reagent to a certain temperature before use, and to ensure the volume of the heated reagent.

[0027] In another embodiment of the related technology, the detection component of the blood cell analyzer may include a sheath flow chamber. The sheath flow chamber is used to encapsulate the sample liquid with sheath fluid, so that the sample liquid passes through the detection site at a stable speed and width to achieve the purpose of detection and counting. To ensure the pressure and flow rate at the detection site, a reservoir is designed in the sheath fluid channel of the sheath flow chamber to stabilize the pressure and flow rate of the sheath fluid in advance.

[0028] Therefore, the reagent preheating components and / or sheath flow cells mentioned above in related technologies can be referred to as liquid storage components. In order to better remove air bubbles present in the reagent, the liquid storage components are usually designed with a bottom-in, top-out structure, so that the fluid movement direction is from bottom to top, and the air bubbles in the fluid float upward and are discharged, thereby reducing the impact of air bubbles on the analyzer detection. However, with the above structure and the bottom-up fluid movement, some reagent will always remain in the cavity of the liquid storage component and cannot be discharged. If the reagent remains in the cavity for too long, it will lead to crystal precipitation.

[0029] To prevent reagents from evaporating and crystallizing inside hematology analyzers, related technologies typically require rinsing the tubing and chambers with pure or distilled water after emptying the instrument. However, when rinsing the reservoir assembly with water, the bottom-inlet, top-outlet structure still presents the problem of water not being completely drained. Related technologies also employ continuous water rinsing of the reservoir assembly to dilute the reagents and reduce the probability of crystallization blockage, but this method still cannot completely empty the reservoir assembly, is complex to operate, and has low reliability.

[0030] In view of this, the present application first proposes a blood cell analyzer. Please refer to... Figure 1 , Figure 1 This is a schematic diagram of the structure of the first embodiment of the blood cell analyzer provided in this application. Figure 1 As shown, in this embodiment, the blood cell analyzer includes a liquid storage component 10, a liquid drainage component 20, and a processor 30.

[0031] The liquid storage assembly 10 includes a liquid storage chamber 11, which has an inlet and an outlet, with the height of the inlet being less than the height of the outlet. The liquid drainage assembly 20 includes a temporary storage mechanism 21, a pressure supply mechanism 22, and a first control valve 23. The first end of the temporary storage mechanism 21 is connected to the pressure supply mechanism 22 via a pipeline, and the second end of the temporary storage mechanism 21 is connected to the inlet of the liquid storage assembly 10 via the first control valve 23. The processor 30 is connected to the liquid drainage assembly 20. The processor 30 is used to control the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state in response to receiving a drainage command. The processor 30 is also used to control the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, so that the liquid in the liquid storage chamber 11 is discharged through the pipeline between the first control valve 23 and the liquid storage assembly 10.

[0032] Specifically, the aforementioned liquid drainage assembly 20 includes pipes, valves, pumps, and other control components connected to the inlet of the liquid storage assembly 10. The pressure supply mechanism 22 provides a preset air pressure environment for the temporary storage mechanism 21, so that the temporary storage mechanism 21 is in a positive pressure state or a negative pressure state. When the pressure supply mechanism 22 switches the temporary storage mechanism 21 to a negative pressure state, the first control valve 23 opens the liquid storage assembly 10 and the temporary storage mechanism 21, which means that the pipe between the temporary storage mechanism 21 and the inlet of the liquid storage assembly 10 is in a negative pressure environment. The liquid in the liquid storage chamber 11 can be drawn out by the negative pressure through the inlet and discharged through the pipe between the first control valve 23 and the liquid storage assembly 10.

[0033] At this time, the processor 30 is used to change the pressure state of the pipeline by controlling at least one of the temporary storage mechanism 21, the pressure supply mechanism 22, and the first control valve 23, so as to control the liquid flow of the liquid storage assembly 10. The processor 30 may be, but is not limited to, a CPU (Central Processing Unit), an integrated circuit chip, a general-purpose processor, a digital signaling processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, or other devices with signal processing capabilities.

[0034] The liquid storage assembly 10 has a liquid storage chamber 11 with an inlet and an outlet. When the hematology analyzer is placed on a table or the ground, the height between the inlet and the ground is less than the height between the outlet and the ground; alternatively, the hematology analyzer includes a frame, and the height between the inlet and the base plane of the frame is less than the height between the outlet and the base plane. When the liquid storage chamber 11 is used for reagent storage, reagents enter the liquid storage chamber 11 through the inlet; when the hematology analyzer needs to use the reagents stored in the liquid storage chamber 11, the reagents flow out of the liquid storage chamber 11 through the outlet to a designated location.

[0035] In this embodiment, the liquid storage assembly 10 of the hematology analyzer includes a liquid storage chamber 11 with an inlet and an outlet, the height of the inlet being less than the height of the outlet. The first end of the temporary storage mechanism 21 of the liquid drainage assembly 20 is connected to the pressure supply mechanism 22 via a pipeline, and the second end of the temporary storage mechanism 21 is connected to the inlet of the liquid storage assembly 10 via a first control valve 23. The processor 30, in response to receiving a drainage command, controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state. The processor 30 is also used to control the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, so that the liquid in the liquid storage chamber 11 is discharged through the pipeline between the first control valve 23 and the liquid storage assembly 10. Therefore, this embodiment can use the temporary storage mechanism 21 under negative pressure to drain the liquid in the liquid storage chamber 11 through the pipeline between the first control valve 23 and the liquid storage assembly 10, thereby removing residual reagents from the liquid storage chamber 11, reducing or avoiding blockages caused by reagent evaporation and crystallization, and improving the service life and reliability of the hematology analyzer.

[0036] In some embodiments, see Figure 2 and Figure 3 , Figure 2 This is a schematic diagram of the structure of the second embodiment of the blood cell analyzer provided in this application. Figure 3 This is a schematic diagram of the third embodiment of the blood cell analyzer provided in this application. Figures 2-3 As shown, the blood cell analyzer also includes a liquid collection assembly 40, which is connected to the outlet of the liquid storage assembly 10. The processor 30, in response to receiving a discharge command, controls the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, and first controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state, allowing liquid to be discharged through the outlet to the liquid collection assembly 40; then controls the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, and controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state, allowing liquid to be discharged through the pipeline between the inlet, the first control valve 23, and the liquid storage assembly 10.

[0037] Specifically, the liquid collection component 40 is used to collect the reagents from the liquid storage component 10. In one embodiment, as... Figure 2 As shown, when the liquid storage assembly 10 is used as a reagent preheating device to preheat reagents, the liquid collection assembly 40 can be some component that uses heated reagents. For example, the liquid collection assembly 40 is an incubation assembly 60, used for sample incubation through the reagent in the liquid storage assembly 10. In another embodiment, such as... Figure 3 As shown, the liquid storage component 10 serves as a sheath flow pool to store a portion of the sheath fluid to ensure the stability of the sheath fluid during the sheath flow process. At this time, the liquid collection component 40 can be a waste liquid collection component connected to the outlet.

[0038] At this time, when the liquid storage component 10 is emptied, the processor 30 controls the first control valve 23 to open the liquid storage component 10 and the temporary storage mechanism 21, and first controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state, so that the liquid is directly discharged to the liquid collection component 40 through the outlet. However, the liquid at the bottom of the liquid storage component 10 cannot be discharged directly. The processor 30 also controls the first control valve 23 to open the liquid storage component 10 and the temporary storage mechanism 21, and controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state, so that the liquid remaining in the liquid storage component 10 is attracted by the negative pressure in the pipeline and discharged through the pipeline between the inlet, the first control valve 23 and the liquid storage component 10.

[0039] In one possible configuration, the temporary storage mechanism 21 includes a power pump 211, and the pressure supply mechanism 22 includes a fifth control valve 221 and a first pressure source 222. The first pressure source 222 includes a positive pressure source 2221 and a negative pressure source 2222. The first end of the fifth control valve 221 is connected to the positive pressure source 2221 via a pipeline, the second end of the fifth control valve 221 is connected to the negative pressure source 2222 via a pipeline, and the third end of the fifth control valve 221 is connected to the power pump 211 via a pipeline. In this case, the processor 30 is used to control the fifth control valve 221 to activate the positive pressure source 2221 and the power pump 211, thereby switching the temporary storage mechanism 21 to a positive pressure state; the processor 30 is also used to control the fifth control valve 221 to activate the negative pressure source 2222 and the power pump 211, thereby switching the temporary storage mechanism 21 to a negative pressure state.

[0040] Therefore, in this embodiment, the hematology analyzer controls the first control valve 23 via the processor 30 to connect the liquid storage assembly 10 and the temporary storage mechanism 21. First, it controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state, allowing the liquid to be discharged through the outlet to the liquid collection assembly 40. Then, it controls the first control valve 23 to connect the liquid storage assembly 10 and the temporary storage mechanism 21, and controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state, allowing the liquid to be discharged through the pipeline between the inlet, the first control valve 23, and the liquid storage assembly 10. This ensures the smooth discharge of liquid at the bottom of the liquid storage chamber 11, improves drainage efficiency, reduces liquid residue in the liquid storage chamber 11, and simplifies operation. It also reduces blockages caused by reagent evaporation and crystallization while ensuring system stability, thus improving the lifespan and reliability of the hematology analyzer.

[0041] In some embodiments, the blood cell analyzer includes a reagent supply component 50, a temporary storage mechanism 21 includes a power pump 211, a first end of a first control valve 23 is connected to the power pump 211 via a pipeline, a second end of the first control valve 23 is connected to the reagent supply component 50 via a pipeline, and a third end of the first control valve 23 is connected to the liquid storage component 10 via a pipeline.

[0042] The processor 30 is configured to: in response to receiving a drain command, control the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state; control the first control valve 23 to open the power pump 211 and the liquid storage assembly 10 so that the power pump 211 draws liquid from the pipeline between the liquid storage chamber 11 and the first control valve 23; control the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state, and control the first control valve 23 to open the power pump 211 and the reagent supply assembly 50 so that the power pump 211 drains the drawn liquid to the reagent supply assembly 50.

[0043] Specifically, the drain command received by the processor 30 can be an operation command generated when performing a fluid draining operation on the hematology analyzer. Upon receiving the drain command, the processor 30 controls the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state and controls the first control valve 23 to open the power pump 211 and the liquid storage assembly 10, so that the power pump 211 draws liquid from the pipeline between the liquid storage chamber 11 and the first control valve 23. After the power pump 211 draws a sufficient amount of liquid from the liquid storage assembly 10, the processor 30 further controls the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state and controls the first control valve 23 to open the power pump 211 and the reagent supply assembly 50, so that the power pump 211 discharges the drawn liquid to the reagent supply assembly 50. After the drawn liquid is discharged into the reagent supply assembly 50, the processor 30 is also used to return to the execution steps of the control pressure supply mechanism 22 switching the power pump 211 to a negative pressure state and controlling the first control valve 23 to open the power pump 211 and the liquid storage assembly 10, and to execute subsequent steps to repeat the operation multiple times until the liquid in the liquid storage chamber 11 is emptied. In a possible manner, the liquid drawing capacity of the power pump 211 is fixed. In this case, the power pump 211 can be, but is not limited to, a metering pump.

[0044] Therefore, the blood cell analyzer in this embodiment can control the power pump 211 to switch between negative and positive pressure states through the processor 30, so that the power pump 211 can draw out the liquid in the storage chamber 11 and discharge the drawn liquid to the reagent supply assembly 50. The operation method is simple, the complexity of the liquid pipeline is reduced and the maintenance cost is lowered, and the service life and reliability of the blood cell analyzer are improved.

[0045] In some embodiments, such as Figure 2As shown, the reagent supply assembly 50 is used to provide the first reagent; before the power pump 211 draws liquid from the pipeline between the storage chamber 11 and the first control valve 23, the processor 30 is also used to: control the first control valve 23 to connect the power pump 211 and the reagent supply assembly 50, and control the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state so that the power pump 211 draws the first reagent from the reagent supply assembly 50; control the first control valve 23 to connect the power pump 211 and the storage assembly 10, and control the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state so that the power pump 211 discharges the drawn first reagent to the storage assembly 10 to clean the storage assembly 10.

[0046] Specifically, the reagent supply component 50 is used to provide a first reagent to the liquid storage component 10. The first reagent can be, but is not limited to, pure water or deionized water. The reagent supply component 50 may include a first storage bottle 51 for storing the first reagent, which is connected to the first control valve 23 via a pipeline. Upon receiving a discharge command, the processor 30 controls the first control valve 23 to activate the power pump 211 and the liquid storage component 10, and controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state, so as to discharge the reagent liquid above the outlet in the liquid storage component 10 to the liquid collection component 40 (or incubation component 60). After the reagent above the outlet is emptied, the processor 30 further controls the first control valve 23 to activate the power pump 211 and the reagent supply component 50, and controls the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state, so that the power pump 211 draws the first reagent from the reagent supply component 50. The processor 30 is also used to control the first control valve 23 to turn on the power pump 211 and the liquid storage assembly 10, and to control the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state so that the power pump 211 discharges the first reagent to the liquid storage assembly 10. Therefore, the pipeline between the liquid storage assembly 10 and the first control valve 23 can be cleaned and the liquid inside the liquid storage chamber 11 can be diluted by the first reagent.

[0047] After cleaning is completed, for example, after repeatedly executing the steps of the power pump 211 drawing the first reagent from the reagent supply assembly 50 and the power pump 211 discharging the drawn first reagent into the liquid storage assembly 10, the processor 30 is further configured to execute the steps of controlling the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state; controlling the first control valve 23 to open the power pump 211 and the liquid storage assembly 10 so that the power pump 211 draws liquid from the pipeline between the liquid storage chamber 11 and the second control valve 213; controlling the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state, and controlling the first control valve 23 to open the power pump 211 and the reagent supply assembly 50 so that the power pump 211 discharges the drawn liquid into the reagent supply assembly 50. This achieves the complete discharge of liquid from the liquid storage assembly 10 into the reagent supply assembly 50.

[0048] Therefore, the blood cell analyzer in this embodiment uses the processor 30 to coordinate the control of the power pump 211, the first control valve 23 and the pressure supply mechanism 22, so that the liquid in the liquid storage component 10 can be drained while the pipeline between the first control valve 23 and the liquid storage component 10 is cleaned by the first reagent. This helps to reduce the risk of liquid crystallization in the pipeline, reduce or avoid blockage caused by reagent evaporation and crystallization, and further improve the service life and reliability of the blood cell analyzer.

[0049] Optionally, please see Figure 4 , Figure 4 This is a schematic diagram of the fourth embodiment of the blood cell analyzer provided in this application. Figure 4 As shown, the blood cell analyzer also includes an incubation component 60, a reagent supply component 50 for providing a second reagent, and the incubation component 60 is connected to the outlet of the reservoir component 10.

[0050] In one possible manner, before the power pump 211 draws liquid from the pipeline between the storage chamber 11 and the first control valve 23, the processor 30 controls the power pump 211 to draw the second reagent from the reagent supply assembly 50 when the first control valve 23 is open to the power pump 211 and the reagent supply assembly 50 and the power pump 211 is in a negative pressure state; when the first control valve 23 is open to the power pump 211 and the storage assembly 10 and the power pump 211 is in a positive pressure state, the processor 30 controls the power pump 211 to discharge the drawn second reagent to the storage assembly 10, so as to replenish the second reagent to the storage assembly 10.

[0051] Specifically, the incubation component 60 is the aforementioned liquid collection component 40, and the reagent supply component 50 includes a second storage bottle 52 for storing the second reagent. The second storage bottle 52 is connected to the first control valve 23 via a pipeline. Therefore, in the normal operation of the hematology analyzer, the processor 30 controls the first control valve 23 to activate the power pump 211 and the reagent supply component 50, and controls the power supply mechanism to switch the power pump 211 to a negative pressure state, so that the power pump 211 draws the second reagent from the reagent supply component 50 under negative pressure. The processor 30 is also used to control the first control valve 23 to activate the power pump 211 and the liquid storage component 10, and controls the power supply mechanism to switch the power pump 211 to a positive pressure state, so that the power pump 211 discharges the drawn second reagent through the pipeline and enters the liquid storage component 10 through the inlet under positive pressure. At this time, the liquid storage component 10 can be used as a temporary storage component for the second reagent, or the liquid storage component 10 can also include a heating mechanism disposed in the liquid storage cavity 11, which is used to heat the second reagent in the liquid storage cavity 11 to achieve preheating of the second reagent.

[0052] In another possible manner, before the power pump 211 draws liquid from the pipeline between the storage chamber 11 and the first control valve 23, the processor 30 controls the first control valve 23 to open the storage assembly 10 and the power pump 211, and controls the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state so that the liquid in the storage chamber 11 is discharged through the outlet to the incubation assembly 60.

[0053] Specifically, when the incubation assembly 60 needs to use the preheated second reagent, the storage chamber 11 stores a sufficient amount of the second reagent. The processor 30 controls the first control valve 23 to open the storage assembly 10 and the power pump 211, and controls the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state, so that the second reagent in the storage chamber 11 is discharged into the incubation assembly 60 through the outlet under positive pressure.

[0054] Alternatively, in response to receiving a drain command, the processor 30 first disconnects the reagent supply assembly 50 from the power pump 211, so that the power pump 211 is connected to an external air source through the second end of the first control valve 23. That is, the storage bottle of the reagent supply assembly 50 is removed, so that the power pump 211 is connected to the external air through the first control valve 23. The processor 30 is also used to first control the first control valve 23 to connect the external air source and the power pump 211, and control the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state so that the power pump 211 draws in the reagent and / or external air from the pipeline between the first control valve 23 and the external air source; then control the first control valve 23 to connect the liquid storage assembly 10 and the power pump 211, and control the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state so that the power pump 211 pumps the gas, liquid and / or liquid between the first control valve 23 and the liquid storage assembly 10 into the liquid storage assembly 10, and discharges the liquid in the liquid storage assembly 10 through the outlet to the incubation assembly 60. At this time, the processor 30 can be used to repeatedly execute the steps of controlling the first control valve 23 to open the external air source and the power pump 211, controlling the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state, and controlling the first control valve 23 to open the liquid storage component 10 and the power pump 211, and controlling the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state, until all the liquid in the liquid storage component is discharged to the incubation component 60 through the outlet. Here, "all discharge" can be understood as the vast majority being discharged, with a small amount of liquid remaining at the bottom or side wall due to contact between the liquid and the liquid storage component.

[0055] Therefore, the blood cell analyzer in this embodiment can achieve the absorption and discharge of the second reagent by precisely controlling the power pump 211, the first control valve 23 and the pressure supply mechanism 22 through the processor 30, thereby ensuring the normal use of the incubation component 60 and improving the efficiency and accuracy of detection.

[0056] In a possible configuration, when the liquid storage assembly 10 is used as a reagent preheating assembly, the first control valve 23 and the fifth control valve 221 may be, but are not limited to, three-way valves; alternatively, the first control valve 23 and the fifth control valve 221 may be other valve devices capable of controlling three liquid channels. In this case, when the fifth control valve 221 is not externally driven, it connects the negative pressure source 2222 and the power pump 211; when the processor 30 controls the fifth control valve 221 to open, it connects the positive pressure source 2221 and the power pump 211. When the first control valve 23 is not externally driven, it connects the reagent supply assembly 50 and the power pump 211; when the processor 30 controls the first control valve 23 to open, it connects the liquid storage assembly 10 and the power pump 211.

[0057] In some embodiments, the blood cell analyzer includes a reagent supply component 50, a temporary storage mechanism 21 including a storage tank 212, a power pump 211 and a second control valve 213, the power pump 211 being connected to the storage tank 212 via the second control valve 213, the storage tank 212 being connected to the storage component 10 via the first control valve 23, and a pressure supply mechanism 22 being connected to the storage tank 212 and the power pump 211 respectively.

[0058] Specifically, in this embodiment, the liquid stored in the storage chamber 11 of the liquid storage assembly 10 is sheath fluid, which is used to assist in the sample sheath flow detection of the liquid storage assembly 10; or, the liquid in the storage chamber 11 is a mixture of sheath fluid, sample solution, diluent, cleaning solution, detection reagent, etc., in any combination. In this case, the storage tank 212 is used to store the sheath fluid reagent. During the sheath flow detection process, the pressure supply mechanism 22 is used to provide a positive pressure environment for the storage tank 212, so that the sheath fluid reagent in the storage tank 212 enters the liquid storage assembly 10 for use through the pipeline between the storage tank 212 and the first control valve 23 under positive pressure.

[0059] The processor 30 is configured to: respond to receiving a discharge command, control the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state, and control the second control valve 213 to open the storage tank 212 and the power pump 211 so that the power pump 211 draws air from the storage tank 212; when the air pressure in the storage tank 212 reaches a preset condition, control the first control valve 23 to open the storage tank 212 and the storage assembly 10 so that the liquid in the storage chamber 11 is discharged to the storage tank 212 through the pipeline between the inlet, the first control valve 23 and the storage assembly 10.

[0060] Specifically, when the drain command instructs the storage component 10 to perform a drain operation, the processor 30 controls the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state and controls the second control valve 213 to open the storage tank 212 and the power pump 211 so that the power pump 211 draws air from the storage tank 212 and the air pressure in the storage tank 212 drops. When the air pressure in the storage tank 212 reaches the preset condition, that is, when the pressure value inside the storage tank 212 reaches the preset negative pressure value, the processor 30 is also used to control the first control valve 23 to open the storage tank 212 and the storage component 10, so that the pipeline between the storage tank 212 and the storage component 10 is in a negative pressure environment. Under the action of negative pressure, the liquid in the storage cavity 11 is discharged into the storage tank 212 through the inlet, the pipeline between the first control valve 23 and the storage component 10, thereby realizing the emptying of the storage cavity 11. It can be understood that the emptying here means that all the residual liquid in the storage cavity 11 is drained away.

[0061] In one possible configuration, the hematology analyzer also includes a reagent supply assembly 50 for supplying sheath fluid reagent. For example, the reagent supply assembly 50 includes a third storage bottle 53 connected to a power pump 211 via a second control valve 213. In this case, the power pump 211 can also draw sheath fluid reagent from the reagent supply assembly 50 and discharge it into a reservoir 212 to replenish the reagent in the reservoir 212.

[0062] Therefore, when the hematology analyzer in this embodiment receives a drain command, the processor 30 controls the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state, and controls the second control valve 213 to open the storage tank 212 and the power pump 211, so that the power pump 211 draws air from the storage tank 212 and makes the air pressure in the storage tank 212 reach a preset negative pressure value. The processor 30 is also used to control the first control valve 23 to open the storage tank 212 and the storage assembly 10, so that the liquid in the storage chamber 11 is discharged into the storage tank 212 through the inlet under the negative pressure of the storage tank 212, thereby removing residual reagents in the storage chamber 11, reducing or avoiding blockage failures caused by reagent evaporation and crystallization, and improving the service life and reliability of the hematology analyzer.

[0063] In some embodiments, the liquid drain assembly 20 further includes a third control valve 24 and a drain branch 25. The first end of the third control valve 24 is connected to the pipeline between the storage tank 212 and the first control valve 23, and the second end of the third control valve 24 is connected to the drain branch 25. The processor 30 is also used to control the first control valve 23 to cut off and control the third control valve 24 to open, so that the liquid in the storage tank 212 is discharged to the drain branch 25.

[0064] Specifically, the third control valve 24 is used to control the liquid flow direction in the pipeline between the storage tank 212 and the first control valve 23. After the residual reagent is drawn from the storage chamber 11 through the storage tank 212, the processor 30 controls the first control valve 23 to shut off, thereby blocking the pipeline connection between the storage tank 212 and the storage assembly 10. The processor 30 is also used to control the third control valve 24 to open, thereby opening the pipeline between the storage tank 212 and the drain branch 25, so that the liquid in the storage tank 212 can be discharged through the drain branch 25 without affecting the normal operation of other liquid circuit systems.

[0065] Therefore, in this embodiment, the processor 30 can control the third control valve 24 and the first control valve 23 to achieve rapid emptying of the liquid in the storage tank 212, preventing residual liquid from flowing back into the storage component 10. The liquid drainage operation is simple and quick.

[0066] In some embodiments, the pressure supply mechanism 22 includes a first pressure source 222, a second pressure source 223, and a fourth control valve 224. The first pressure source 222 is connected to the power pump 211, and the second pressure source 223 is connected to the storage tank 212 through the fourth control valve 224. The second pressure source 223 is used to provide positive pressure to the storage tank 212. The blood cell analyzer also includes a liquid collection assembly 40, which is connected to the outlet of the storage assembly 10.

[0067] Before the liquid in the storage chamber 11 is discharged to the storage tank 212 through the pipeline between the inlet, the first control valve 23 and the storage assembly 10, the processor 30 is used to respond to the received discharge command by controlling the first control valve 23 to open the storage assembly 10 and the storage tank 212, and controlling the fourth control valve 224 to open, so that the storage tank 212 discharges the liquid in the storage chamber 11 through the outlet to the liquid collection assembly 40 under the positive pressure of the second pressure source 223.

[0068] Specifically, when the liquid storage assembly 10 needs to be emptied, the processor 30 controls the first control valve 23 to open the liquid storage assembly 10 and the liquid storage tank 212, and controls the fourth control valve 224 to open, so that the liquid storage tank 212 discharges part of the liquid in the liquid storage cavity 11 to the liquid collection assembly 40 under the positive pressure of the second pressure source 223. The processor 30 is also used to execute the steps of controlling the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state, and controlling the second control valve 213 to open the liquid storage tank 212 and the power pump 211, so that the power pump 211 draws air from the liquid storage tank 212 and subsequent steps. Therefore, the processor 30 can flexibly respond to different liquid discharge needs by controlling the fourth control valve 224 to control the pressure of the second pressure source 223, and drive the power pump 211 through the first pressure source 222, ensuring the safety and reliability of the liquid discharge process.

[0069] Before the liquid in the storage chamber 11 is discharged to the storage tank 212 through the pipeline between the inlet, the first control valve 23 and the storage assembly 10, the processor 30 is also used to respond to the received discharge command by controlling the second control valve 213 to turn on the power pump 211 and the storage tank 212, and controlling the first pressure source 222 to switch the power pump 211 to a positive pressure state so that the power pump 211 discharges the drawn reagent to the storage assembly 10 to clean the storage assembly 10.

[0070] In some embodiments, the liquid drain assembly 20 further includes a waste liquid storage mechanism 26. The first end of the second control valve 213 is connected to the power pump 211 via a pipeline, the second end of the second control valve 213 is connected to the storage tank 212 via a pipeline, and the third end of the second control valve 213 is connected to the waste liquid storage mechanism 26 via a pipeline. The temporary storage mechanism 21 further includes a sixth control valve 27, through which the waste liquid storage mechanism 26 is connected to the pipeline between the second control valve 213 and the third storage bottle 53.

[0071] The processor 30 is configured to: respond to receiving a drain command, first control the second pressure source 223 to switch the power pump 211 to a positive pressure state, and control the second control valve 213 to open the power pump 211 and the waste liquid storage mechanism 26, so as to drain the gas and / or liquid from the power pump 211 to the waste liquid storage mechanism 26; then control the second pressure source 223 to switch the power pump 211 to a negative pressure state, and control the second control valve 213 to open the storage tank 212 and the power pump 211, so that the power pump 211 draws air from the storage tank 212; return to repeat the steps of controlling the second pressure source 223 to switch the power pump 211 to a positive pressure state and controlling the second control valve 213 to open the power pump 211 and the waste liquid storage mechanism 26, and controlling the second pressure source 223 to switch the power pump 211 to a negative pressure state and controlling the second control valve 213 to open the storage tank 212 and the power pump 211, until the air pressure in the storage tank 212 reaches a preset condition.

[0072] Specifically, when the drain command instructs the liquid in the storage chamber 11 to be emptied, the processor 30 controls the first control valve 23 to open the storage assembly 10 and the storage tank 212, and controls the fourth control valve 224 to open, so that the storage tank 212 discharges most of the liquid in the storage chamber 11 to the liquid collection assembly 40 under the positive pressure of the second pressure source 223. The processor 30 is also used to control the second pressure source 223 to switch the power pump 211 to a positive pressure state, and controls the second control valve 213 to open the power pump 211 and the waste liquid storage mechanism 26, and controls the sixth control valve 27 to open, so that the liquid in the power pump 211 is discharged to the waste liquid storage mechanism 26 under the action of positive pressure. The processor 30 is also used to control the second pressure source 223 to switch the power pump 211 to a negative pressure state, and to control the second control valve 213 to connect the storage tank 212 and the power pump 211, so that the power pump 211, under negative pressure, draws air from the storage tank 212 and draws out residual liquid in the pipeline between the storage tank 212 and the second control valve 213. As the power pump 211 draws out the air inside the storage tank 212, the air pressure inside the storage tank 212 decreases.

[0073] The processor 30 is also used to repeatedly execute the steps of discharging the liquid in the power pump 211 to the waste liquid storage mechanism 26, and subsequently executing the steps of the power pump 211 drawing air from the storage tank 212. Therefore, by repeatedly drawing air from the storage tank 212, the air pressure inside the storage tank 212 is gradually reduced until a preset negative pressure value is reached and the storage tank 212 is in a negative pressure environment. The processor 30 is also used to control the first control valve 23 to open the storage tank 212 and the storage assembly 10 when the air pressure in the storage tank 212 reaches the preset condition, so that the liquid in the storage chamber 11 enters the storage tank 212; and to control the third control valve 24 to open, so that the liquid in the storage tank 212 is discharged through the drain branch 25.

[0074] Therefore, the blood cell analyzer in this embodiment can reduce the gas pressure inside the storage tank 212 through multiple suction and discharge operations of the power pump 211, and allow the liquid in the storage chamber 11 to be sucked out under negative pressure in the storage tank 212, so as to remove residual reagents in the storage chamber 11 and reduce or avoid blockage failures caused by reagent evaporation and crystallization; the liquid and gas sucked by the power pump 211 in the storage tank 212 can be discharged through the waste liquid storage mechanism 26, reducing environmental pollution and improving the reliability of the blood cell analyzer.

[0075] In a possible configuration, when the liquid storage assembly 10 is used as a sheath flow reservoir, the second control valve 213 and the fifth control valve 221 can be, but are not limited to, three-way valves; alternatively, the second control valve 213 and the fifth control valve 221 can be other valve devices capable of controlling three liquid passages. In this case, when the fifth control valve 221 is not externally driven, it connects the negative pressure source 2222 and the power pump 211; when the processor 30 controls the fifth control valve 221 to open, it connects the positive pressure source 2221 and the power pump 211. When the second control valve 213 is not externally driven, it connects the third storage bottle 53 and the power pump 211; when the processor 30 controls the second control valve 213 to open, it connects the liquid storage tank 212 and the power pump 211. Among them, the first control valve 23, the third control valve 24, the fourth control valve 224 and the sixth control valve 27 are two-way valves, or other valve devices that can realize the control of two liquid passages.

[0076] This application also proposes a blood cell analysis method applicable to the blood cell analyzer described in any of the above embodiments. Please refer to... Figure 5 , Figure 5 This is a schematic flowchart of an embodiment of the blood cell analysis method provided in this application. Figure 5 As shown, this blood cell analysis method includes:

[0077] Step S10: In response to receiving the drain command, the temporary storage mechanism 21 is switched to a positive pressure state, and the first control valve 23 is controlled to open the liquid storage component 10 and the temporary storage mechanism 21, so as to drive the reagent into the liquid storage component 10 to clean the liquid storage component 10.

[0078] Specifically, the temporary storage mechanism 21 is used to replenish the reagents in the reservoir assembly 10. In a possible embodiment, the hematology analyzer also includes a reagent supply assembly 50, which provides a first reagent. The hematology analysis method can control the temporary storage mechanism 21 to draw the first reagent from the reagent supply assembly 50 and discharge the first reagent into the reservoir assembly 10, thereby cleaning the tubing between the temporary storage mechanism 21 and the reservoir assembly 10, as well as the reservoir assembly 10 itself, with the first reagent.

[0079] Step S20: Control the liquid in the liquid storage assembly 10 to be discharged from the outlet of the liquid storage assembly 10.

[0080] Specifically, the first control valve 23 can be controlled to open the liquid storage assembly 10 and the temporary storage mechanism 21, and the temporary storage mechanism 21 can be switched to a positive pressure state so that the residual liquid in the liquid storage assembly 10 can be discharged from the outlet of the liquid storage assembly 10.

[0081] Step S30: Switch the temporary storage mechanism 21 to a negative pressure state, and control the first control valve 23 to open the liquid storage component 10 and the temporary storage mechanism 21 so that the liquid in the liquid storage component 10 is discharged through the inlet of the liquid storage component 10, the pipeline between the first control valve 23 and the liquid storage component 10.

[0082] Specifically, the temporary storage mechanism 21 is switched to a negative pressure state, and the first control valve 23 is controlled to open the liquid storage component 10 and the temporary storage mechanism 21, so that the pipeline between the first control valve 23 and the liquid storage component 10 is in a negative pressure environment. Under the action of negative pressure, the liquid in the liquid storage chamber 11 of the liquid storage component 10 enters the pipeline between the first control valve 23 and the liquid storage component 10 through the inlet, and is discharged through the pipeline.

[0083] Therefore, the blood cell analysis method of this embodiment can efficiently discharge the liquid in the storage chamber 11 by switching the temporary storage mechanism 21 to a negative pressure state and using the first control valve 23 to open the pipeline, thereby maintaining the cleanliness and efficiency of the system, removing residual reagents in the storage chamber 11, reducing or avoiding blockage failures caused by reagent evaporation and crystallization, and improving the service life and reliability of the blood cell analyzer.

[0084] In one embodiment, in step S20, the blood cell analysis method includes: in response to receiving a drain command, controlling the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a negative pressure state. In step S30, the blood cell analysis method includes: controlling the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, and causing the liquid in the liquid storage chamber 11 to be discharged through the pipeline between the first control valve 23 and the liquid storage assembly 10.

[0085] Optionally, step S20 includes: controlling the first control valve 23 to open the liquid storage assembly 10 and the temporary storage mechanism 21, and controlling the pressure supply mechanism 22 to switch the temporary storage mechanism 21 to a positive pressure state so that the liquid in the liquid storage chamber 11 is discharged to the liquid collection assembly 40 through the outlet.

[0086] In one embodiment, in step S30, the blood cell analysis method includes: first, controlling the pressure supply mechanism 22 to switch the power pump 211 to a negative pressure state; controlling the first control valve 23 to connect the power pump 211 and the liquid storage assembly 10, so that the power pump 211 draws liquid from the pipeline between the liquid storage chamber 11 and the second control valve 213; then, controlling the pressure supply mechanism 22 to switch the power pump 211 to a positive pressure state, and controlling the first control valve 23 to connect the power pump 211 and the reagent supply assembly 50, so that the power pump 211 discharges the drawn liquid to the reagent supply assembly 50.

[0087] In one embodiment, in step S30, the blood cell analysis method includes: first, controlling the second pressure source 223 to switch the power pump 211 to a positive pressure state, and controlling the second control valve 213 to connect the power pump 211 and the waste liquid storage mechanism 26, so as to discharge the liquid from the power pump 211 to the waste liquid storage mechanism 26; then, controlling the second pressure source 223 to switch the power pump 211 to a negative pressure state, and controlling the second control valve 213 to connect the storage tank 212 and the power pump 211, so that the power pump 211 draws air from the storage tank 212; returning to repeat the steps of controlling the second pressure source 223 to switch the power pump 211 to a positive pressure state and controlling the second control valve 213 to connect the power pump 211 and the waste liquid storage mechanism 26, and controlling the second pressure source 223 to switch the power pump 211 to a negative pressure state and controlling the second control valve 213 to connect the storage tank 212 and the power pump 211, until the air pressure in the storage tank 212 reaches a preset condition.

[0088] In step S30, the blood cell analysis method includes: when the air pressure of the storage tank 212 reaches a preset condition, controlling the first control valve 23 to open the storage tank 212 and the storage assembly 10 so that the liquid in the storage chamber 11 enters the storage tank 212; controlling the first control valve 23 to cut off and controlling the third control valve 24 to open so that the liquid in the storage tank 212 is discharged to the drain branch 25.

[0089] In this application, the blood cell analysis method can be applied during instrument packaging and also during maintenance operations when the blood cell analyzer is not used for an extended period. Specifically, when the blood cell analyzer leaves the factory, all reagents inside the instrument are emptied and rinsed with pure water. The rinsed pure water solution is then drained from the outlet, and finally, residual reagents in the reservoir component 10 (bottom-in, top-out structure) are drained through the inlet. This prevents internal reagent crystallization and blockage, thus avoiding problems with initial packaging issues when the instrument is installed and used by the customer after a period of time. For example, when the blood cell analyzer is not used for an extended period, the instrument automatically initiates a purging process based on user operations. The reservoir component 10 is rinsed with cleaning solution, which is then drained from the outlet. Finally, residual reagents in the reservoir component 10 (bottom-in, top-out structure) are drained through the inlet, preventing problems caused by internal reagent crystallization and blockage during the customer's next use. For example, when the analyzer is exported to foreign regions, customs will scan and detect whether there is a large amount of residual liquid inside the instrument. If there is liquid, it will affect the export of the instrument. The blood cell analysis method of this application is used to clean the inside of the instrument and drain the residual reagent of the liquid storage component 10 through the inlet of the liquid storage component 10 with the bottom inlet and top outlet structure. This avoids the situation where the instrument does not meet the customs requirements for the export of in vitro diagnostic instruments due to reagent residue, which would affect the sale and use of the instrument.

[0090] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A blood cell analyzer characterized by comprising: The blood cell analyzer comprises: a liquid storage assembly comprising a liquid storage cavity, the liquid storage cavity having an inlet and an outlet, the height of the inlet being less than the height of the outlet; a liquid path emptying assembly comprising a temporary storage mechanism, a pressure supply mechanism, and a first control valve, a first end of the temporary storage mechanism being connected to the pressure supply mechanism through a pipeline, a second end of the temporary storage mechanism being connected to the inlet of the liquid storage assembly through the first control valve; a processor connected to the liquid path emptying assembly; wherein the processor is configured to, in response to receiving a liquid emptying instruction, control the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state, and control the first control valve to open the liquid storage assembly and the temporary storage mechanism, so that the liquid in the liquid storage cavity is discharged through the pipeline between the first control valve and the liquid storage assembly; the blood cell analyzer further comprises a liquid collection assembly connected to the outlet of the liquid storage assembly; the processor is configured to: in response to receiving the liquid emptying instruction, control the first control valve to open the liquid storage assembly and the temporary storage mechanism, and first control the pressure supply mechanism to switch the temporary storage mechanism to a positive pressure state, so that the liquid in the liquid storage cavity is discharged through the outlet to the liquid collection assembly; then control the first control valve to open the liquid storage assembly and the temporary storage mechanism, and control the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state, so that the liquid in the liquid storage cavity is discharged through the pipeline between the inlet, the first control valve, and the liquid storage assembly.

2. The blood cell analyzer according to claim 1, wherein, The blood cell analyzer comprises a reagent supply assembly, the temporary storage mechanism comprises a power pump, a first end of the first control valve is connected to the power pump through the pipeline, a second end of the first control valve is connected to the reagent supply assembly through the pipeline, and a third end of the first control valve is connected to the liquid storage assembly through the pipeline; wherein the processor is configured to: in response to receiving the liquid emptying instruction, control the pressure supply mechanism to switch the power pump to the negative pressure state; control the first control valve to open the power pump and the liquid storage assembly, so that the power pump sucks the liquid in the pipeline between the liquid storage cavity and the first control valve; control the pressure supply mechanism to switch the power pump to a positive pressure state, and control the first control valve to open the power pump and the reagent supply assembly, so that the power pump discharges the sucked liquid to the reagent supply assembly.

3. The blood cell analyzer according to claim 2, wherein, The reagent supply assembly is configured to provide a first reagent; before the power pump sucks the liquid in the pipeline between the liquid storage cavity and the first control valve, the processor is further configured to: control the first control valve to open the power pump and the reagent supply assembly, and control the pressure supply mechanism to switch the temporary storage mechanism to a negative pressure state, so that the power pump sucks the first reagent of the reagent supply assembly; The first control valve is controlled to be in a conductive state with the power pump and the reagent supply assembly, and the pressure supply mechanism is controlled to switch the power pump to the positive pressure state, so that the power pump discharges the first reagent sucked to the reagent supply assembly, and the reagent supply assembly is cleaned.

4. The blood cell analyzer of claim 2, wherein, The blood cell analyzer further comprises an incubation assembly, the reagent supply assembly is configured to supply a second reagent, and the incubation assembly is connected to an outlet of the reagent supply assembly; before the power pump sucks the liquid in the pipeline between the reagent supply assembly and the first control valve, the processor is further configured to: when the first control valve is in a conductive state with the power pump and the reagent supply assembly and the temporary storage mechanism is in the negative pressure state, the power pump is controlled to suck the second reagent in the reagent supply assembly; when the first control valve is in a conductive state with the power pump and the reagent supply assembly and the temporary storage mechanism is in the positive pressure state, the power pump is controlled to discharge the second reagent sucked to the reagent supply assembly, so that the second reagent is replenished to the reagent supply assembly; and / or, the first control valve is controlled to be in a conductive state with the reagent supply assembly and the power pump, and the pressure supply mechanism is controlled to switch the power pump to the positive pressure state, so that the liquid in the reagent supply assembly is discharged to the incubation assembly through the outlet.

5. The blood cell analyzer of claim 1, wherein, The blood cell analyzer comprises a reagent supply assembly, the temporary storage mechanism comprises a reagent tank, a power pump and a second control valve, the power pump is connected to the reagent tank through the second control valve, the reagent tank is connected to the reagent supply assembly through the first control valve, and the pressure supply mechanism is connected to the reagent tank and the power pump respectively; The processor is configured to: in response to receiving the liquid discharge instruction, the pressure supply mechanism is controlled to switch the power pump to the negative pressure state, and the second control valve is controlled to be in a conductive state with the reagent tank and the power pump, so that the power pump sucks the air in the reagent tank; when the air pressure in the reagent tank reaches a preset condition, the first control valve is controlled to be in a conductive state with the reagent tank and the reagent supply assembly, so that the liquid in the reagent supply assembly is discharged to the reagent tank through the pipeline between the inlet, the first control valve and the reagent supply assembly.

6. The blood cell analyzer of claim 5, wherein, The liquid path emptying assembly further comprises a third control valve and a liquid discharge branch, a first end of the third control valve is connected to the pipeline between the reagent tank and the first control valve, and a second end of the third control valve is connected to the liquid discharge branch; The processor is further configured to control the first control valve to be in a cut-off state and control the third control valve to be in a conductive state, so that the liquid in the reagent tank is discharged to the liquid discharge branch.

7. The blood cell analyzer of claim 5 wherein, The pressure supply mechanism comprises a first pressure source, a second pressure source and a fourth control valve, the first pressure source is connected to the power pump, the second pressure source is connected to the reagent tank through the fourth control valve, the second pressure source is configured to provide positive pressure for the reagent tank, and the blood cell analyzer further comprises a liquid collection assembly connected to an outlet of the reagent supply assembly. The processor is configured to, in response to receiving the liquid discharge instruction, control the first control valve to connect the storage assembly and the storage tank, and control the fourth control valve to be connected, so that the storage tank discharges the liquid in the storage cavity to the liquid collection assembly under the positive pressure of the second pressure source. The processor is further configured to, in response to receiving the liquid discharge instruction, control the second control valve to connect the power pump and the storage tank, and control the first pressure source to switch the power pump to the positive pressure state, so that the power pump discharges the reagent sucked to the storage assembly to clean the storage assembly.

8. The blood cell analyzer of claim 7, wherein, The liquid path emptying assembly further comprises a waste liquid storage mechanism, a first end of the second control valve is connected with the power pump through the pipeline, a second end of the second control valve is connected with the storage tank through the pipeline, and a third end of the second control valve is connected with the waste liquid storage mechanism through the pipeline. The processor is configured to: in response to receiving the liquid discharge instruction, first control the second pressure source to switch the power pump to the positive pressure state, and control the second control valve to connect the power pump and the waste liquid storage mechanism, so as to discharge the liquid in the power pump to the waste liquid storage mechanism; then control the second pressure source to switch the power pump to the negative pressure state, and control the second control valve to connect the storage tank and the power pump, so that the power pump sucks the air in the storage tank; return to repeat the steps of controlling the second pressure source to switch the power pump to the positive pressure state, and controlling the second control valve to connect the power pump and the waste liquid storage mechanism, and the steps of controlling the second pressure source to switch the power pump to the negative pressure state, and controlling the second control valve to connect the storage tank and the power pump, until the air pressure in the storage tank reaches the preset condition.

9. A method of blood cell analysis, characterized by, The blood cell analysis method is applied to the blood cell analyzer of any one of claims 1-8, and the blood cell analysis method comprises: in response to receiving a liquid discharge instruction, switching the temporary storage mechanism to a positive pressure state, controlling the first control valve to connect the storage assembly and the temporary storage mechanism, and driving the reagent into the storage assembly to clean the storage assembly; controlling the liquid in the storage assembly to be discharged from the outlet of the storage assembly; switching the temporary storage mechanism to a negative pressure state, and controlling the first control valve to connect the storage assembly and the temporary storage mechanism, so that the liquid in the storage assembly is discharged through the pipeline between the inlet of the storage assembly, the first control valve and the storage assembly.

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