Composition containing pendimethalin and metamifop

Abstract

The invention provides a composition, the active ingredients of the composition comprise pendimethalin and metamifop, and the weight ratio of the pendimethalin to the metamifop is (1-10): 1. The pendimethalin and the metamifop in the weeding composition disclosed by the invention have an obvious synergistic effect on agricultural weeds in the proportion range. In addition, the composition further comprises a third active component, and the third active component can further improve the prevention and treatment effect of the composition and shows a synergistic effect.

Description

Technical Field

[0001] The invention belongs to the field of agriculture, and particularly relates to a composition comprising pendimethalin and metamifop and an application thereof. Background Art

[0002] Pendimethalin belongs to the dinitrotoluidine family of selective soil treatment herbicides and can be widely used for weed control in a variety of crop fields, including corn, soybeans, peanuts, cotton, rice, potatoes, tobacco, and vegetables. It effectively controls annual grasses and broadleaf weeds, including crabgrass, foxtail grass, bluegrass, foxtail grass, goosegrass, gray mulberry, shrimp intestine, nightshade, quinoa, amaranth, barnyard grass, jackfruit, duckweed, sedge, and Polygonum multiflorum. Pendimethalin works primarily by inhibiting meristem cell division. The primary application method for pendimethalin is soil application before or after sowing, before seedlings emerge.

[0003] Metamifop is an aryloxyphenoxypropionate herbicide developed by the Korea Institute of Chemical Technology. Its mechanism of action is to inhibit acetyl-CoA carboxylase (ACCase) in plants, preventing the synthesis of plant fatty acids and thereby suppressing weed growth. Metamifop can be used after rice reaches the three-leaf, one-heart stage and has a significant control effect on most annual grass weeds, such as barnyardgrass, chinensis, crabgrass, and goosegrass. Metamifop is low in toxicity, environmentally safe, and has low toxicity to aquatic organisms and bees.

[0004] US2016174551A1 discloses a composition containing microencapsulated pendimethalin and a co-herbicide suspension concentrate. In the list of co-herbicides, metamifop is listed as an example, but the specific combination of the two is not disclosed, nor is the effect of the combined use of the two disclosed or taught.

[0005] No research related to the combination of pendimethalin and oxadiazine was found in the prior art. Summary of the Invention

[0006] The present inventors have discovered through research that pendimethalin and metamifop have a synergistic effect in weed control, and based on this, have completed the present invention.

[0007] One aspect of the present invention relates to a composition, wherein the active ingredients of the composition include pendimethalin and metamifop, and the weight ratio of pendimethalin to metamifop is 1-10:1.

[0008] In a preferred embodiment, the weight ratio of pendimethalin to metamifop is preferably 2-5:1, for example, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, or 5:1.

[0009] In a further preferred embodiment, the weight ratio of pendimethalin to metamifop is preferably 2-2.5:1.

[0010] Typically, pendimethalin is used as a closed herbicide for soil treatment, while metamifop is applied as a post-emergence foliar spray. However, the inventors have discovered that combining the two offers significant advantages. Not only do they leverage their respective strengths, combining closed and closed herbicides to effectively control weeds at different stages, but they can also enhance each other's weed control effectiveness. This is particularly evident when the combination is applied post-emergence, where the enhanced effect is even more pronounced.

[0011] The present invention has been tested and confirmed that pendimethalin and metamifop have a significant synergistic effect on agricultural weed control within the ratio range described. However, outside this ratio range, the synergistic effect is weakened, and even no synergistic effect is observed. Therefore, the combination of pendimethalin and metamifop in the ratio described herein is preferred and essential for the present invention.

[0012] In another embodiment of the present invention, the active ingredients of the composition of the present invention include, in addition to pendimethalin and metamifop, a third active ingredient, and the third active ingredient is preferably propanil.

[0013] The addition of the third active ingredient can further enhance the control effect of the aforementioned composition. Specifically, the combination of pendimethalin and oxadixyl creates a synergistic effect with the third active ingredient, propanil, which is very beneficial for controlling agricultural weeds.

[0014] The weight ratio ranges and specific exemplary values ​​of pendimethalin to mefenacet in the aforementioned compositions are applicable to compositions further comprising a third active ingredient in this embodiment. Specifically, when the third active ingredient is included, the weight ratio of pendimethalin to mefenacet to the third active ingredient is 1-10:1:2-15, preferably 2-5:1:3-9, and more preferably 2:1:5.

[0015] In one embodiment of the present invention, the composition further comprises an agriculturally acceptable adjuvant and / or carrier and is prepared into a conventional agricultural formulation.

[0016] In one embodiment of the present invention, the total weight percentage of active ingredients in the composition is 5-60%, preferably 10-50%.

[0017] The agriculturally acceptable adjuvant and / or carrier includes one or more of a solvent, a surfactant, a thickener, a binder, a disintegrant, a defoaming agent, an antifreeze agent, a filler and / or a carrier.

[0018] The solvent includes, but is not limited to, one or more of ethanol, acetone, xylene, dimethylformamide, dimethyl sulfoxide, dichloromethane, ethyl acetate, cyclohexane, cyclohexanone, N-methylpyrrolidone, and cyclohexanol.

[0019] The surfactant includes but is not limited to: styrylphenyl polyoxyethylene ether, styrene polyoxyethylene ether ammonium sulfate, castor oil polyoxyethylene ether, p-methoxy fatty acid amide benzene sulfonate, sodium p-hydroxyphenyl lignin sulfonate, dioctyl sulfosuccinate, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene alkyl aryl ether, polyoxyethylene alkyl aryl ether phosphate salt, polyoxyethylene alkyl ether, polyoxyethylene lanolin alcohol, polyoxyethylene fatty acid ester, lignin sulfonate, naphthalenesulfonic acid formaldehyde condensate sodium salt, naphthalenesulfonate formaldehyde condensate, nonylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether phosphate, triphenethylphenol polyoxyethylene ether, trisiloxane polyoxyethylene ether, sorbitan monostearate, sorbitan fatty acid ester, calcium dodecylbenzenesulfonate, sodium lauryl sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, alkylnaphthalene sulfonate, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, sodium lauroyl sarcosinate, and fatty alcohol polyoxyethylene ether.

[0020] The thickener includes, but is not limited to, one or more of gum arabic, xanthan gum, carboxymethyl cellulose, gelatin, magnesium aluminum silicate, and sodium alginate.

[0021] The binder includes, but is not limited to, one or more of carboxymethyl cellulose, carboxyethyl cellulose, starch, and gelatin.

[0022] The disintegrant includes, but is not limited to, one or more of sodium sulfate, sodium bicarbonate, ammonium sulfate, and calcium sulfate.

[0023] The defoaming agent includes but is not limited to: one or more of butyl phosphate, isobutyl phosphate, n-octanol, and silicone.

[0024] The antifreeze agent includes but is not limited to: one or more of propylene glycol, glycerol, ethylene glycol, and polyethylene glycol.

[0025] The filler / carrier includes solid filler / carrier and liquid filler / carrier, and specific varieties include but are not limited to: bentonite, attapulgite, kaolin, calcium carbonate; one or more of water, soybean oil, corn oil, castor oil, rapeseed oil, and mineral oil.

[0026] In one embodiment of the present invention, the present invention relates to the use of the composition for controlling agricultural weeds. The agricultural weeds are preferably annual agricultural weeds, such as Echinochloa crus-galli, Leptochloa chinensis, Dalbergia vaginalis, Cyperus difformis, and Polygonum sylvestris.

[0027] The composition of the present invention produces a synergistic effect in preventing and controlling the above-mentioned agricultural weeds. DETAILED DESCRIPTION

[0028] The present invention will be further described below with reference to the embodiments, but the present invention is not limited thereto.

[0029] The various reagents used in the following examples of the present invention can be obtained commercially or homemade. In addition, unless otherwise specified, the percentages described in the following examples are all weight percentages.

[0030] 1. Indoor weed control test

[0031] The herbicidal activity of the composition of the present invention was determined according to the "Stem-leaf spray method" in accordance with NY / T 1155.4-2006 Pesticide Indoor Bioassay Test Guidelines for Herbicides Part 4: Activity Determination Test.

[0032] (1) Indoor toxicity test on barnyard grass

[0033] 1. Indoor toxicity test of the combination of pendimethalin and oxadiazon against barnyardgrass

[0034] Test target: barnyard grass (Echinochloacrus-galli);

[0035] Test agents: Pendimethalin technical and Metamifop technical. To prepare the agents, the technicals were first dissolved in an appropriate amount of acetone and then prepared to the desired concentration using a 1% Tween-80 aqueous solution.

[0036] Test Method: Sow barnyard grass in seedling trays. When the barnyard grass reaches the 2-3 leaf stage, spray each treatment (spray volume calculated as 30 L per mu), replicate four times per treatment, and calculate the average value. A treatment without the drug (1% Tween-80 aqueous solution) was also included as a blank control. After the drug solution on the weed leaves air-dried, the weeds were transferred to a greenhouse for conventional cultivation. Fourteen days after treatment, the fresh weight control efficacy of each treatment was assessed:

[0037]

[0038] E: fresh weight prevention effect;

[0039] C: fresh weight of aboveground part of control weeds;

[0040] T: fresh weight of aboveground part of treated weeds;

[0041] Then, the combined effect of the combination was calculated according to Colby's formula (SR Colby, Calculating Synergistic and Antagonistic Responsed of Herbicide Combinations. Weeds, 1967):

[0042]

[0043] X is the control effect when the active ingredient A is applied at an application rate of m, expressed as a percentage of the untreated control group;

[0044] Y is the control effect when the active ingredient B is applied at an application rate of n, expressed as a percentage of the untreated control group;

[0045] E is the control effect when the active ingredients A and B are applied at the application rates m and n, expressed as a percentage of the untreated control.

[0046] If the observed value of the protective effect (actual protective effect) is greater than the theoretical value calculated by the above formula, the composition has superadditivity, that is, there is a synergistic effect.

[0047] The test results of the composition of the present invention on barnyard grass are shown in Table 1 below.

[0048] Table 1 Results of indoor joint toxicity test on barnyard grass

[0049]

[0050] The results in Table 1 show that the combination of pendimethalin and metamifop has a significant synergistic effect on the control of barnyardgrass compared to the application of either alone.

[0051] 2. Indoor toxicity test of the combination of pendimethalin, oxadix and propanil against barnyardgrass

[0052] The synergistic effect of the combination of pendimethalin and mefenacet (abbreviated as pendimethalin·mefenacet) with propanil was determined using a similar method as described above. The results are shown in Table 2 below.

[0053] Table 2 Results of indoor combined toxicity test on barnyardgrass

[0054]

[0055] The results in Table 2 show that there is a further synergistic effect between the combination of propanil and dimethoate, that is, propanil can further enhance the weed control effect of the combination of dimethoate and mefenacet.

[0056] (2) Indoor toxicity test on Leptochloa chinensis

[0057] 1. Indoor toxicity test of the combination of pendimethalin and oxadiazon against Leptochloa chinensis. Test target: Leptochloa chinensis.

[0058] Test agents: Pendimethalin technical and Metamifop technical. To prepare the agents, the technicals were first dissolved in an appropriate amount of acetone and then prepared to the desired concentration using a 1% Tween-80 aqueous solution.

[0059] Test method: Sow Leptochloa chinensis in a seedling tray. When Leptochloa chinensis grows to the 2-3 leaf stage, spray each treatment separately (spray volume is converted to 30L per mu), repeat each treatment 4 times, and take the average value. A treatment without drug (1% Tween-80 aqueous solution) is also set as a blank control. After the drug solution on the surface of the weed leaves is naturally air-dried, move it into the greenhouse for conventional cultivation. Investigate the fresh weight prevention effect of each treatment 14 days after treatment, and evaluate its synergistic effect according to the above method. The results are shown in Table 3 below.

[0060] Table 3 Results of indoor combined toxicity test on Leptochloa chinensis

[0061]

[0062] The results in Table 3 show that the combination of pendimethalin and metamifop has a significant synergistic effect in controlling Leptochloa chinensis compared to the use of either alone.

[0063] 2. Indoor toxicity test of the combination of pendimethalin, oxadixyl and propanil on Leptochloa chinensis

[0064] Using a similar method as described above, the synergistic effect of a combination of pendimethalin and mefenacet at a ratio of 25:8.2 with propanil was determined. The results are shown in Table 4 below.

[0065] Table 4 Results of indoor combined toxicity test on Leptochloa chinensis

[0066]

[0067] The results in Table 4 show that there is a further synergistic effect between the combination of propanil and dimethoate, that is, propanil can further enhance the weed control effect of the combination of pendimethalin and metamifop.

[0068] 2. Preparation Examples

[0069] Example 1 Wettable powder

[0070] Pendimethalin 24%, metamifop 9%, trisiloxane polyoxyethylene ether 5%, calcium dodecylbenzenesulfonate 6%, kaolin to 100%.

[0071] The preparation method comprises the following steps: mixing the components, grinding and pulverizing the components to obtain the wettable powder.

[0072] Example 2 Wettable powder

[0073] Pendimethalin 26%, oxadiazon 8%, propanil 7%, styrylphenyl polyoxyethylene ether 8%, sodium naphthalenesulfonic acid formaldehyde condensate 5%, and attapulgite making up to 100%.

[0074] The preparation method is the same as that of Example 1.

[0075] Example 3: Suspension

[0076] Pendimethalin 20%, metamifop 8%, sodium naphthalenesulfonate formaldehyde condensate 5%, trisiloxane polyoxyethylene ether 7%, silicone 0.5%, magnesium aluminum silicate 3%, ethylene glycol 5%, and the balance water.

[0077] The preparation method is as follows: each component is added into water, mixed and stirred, and then dispersed and ground by high-speed shearing to obtain a suspension.

[0078] Example 4: Suspension

[0079] Pendimethalin 10%, oxadiazon 5%, propanil 25%, nonylphenol polyoxyethylene ether phosphate 5%, sodium naphthalenesulfonic acid formaldehyde condensate 6%, silicone 0.5%, xanthan gum 4%, propylene glycol 4%, balance water.

[0080] The preparation method is the same as Example 3.

[0081] Example 5 Water Dispersible Granules

[0082] Pendimethalin 15%, oxadiazon 3%, propanil 15%, sodium naphthalenesulfonic acid formaldehyde condensate 7%, nonylphenol polyoxyethylene ether 6%, carboxyethyl cellulose 4%, ammonium sulfate 4%, and kaolin as the balance.

[0083] The preparation method comprises the following steps: uniformly mixing and crushing the components except the binder, then adding the binder aqueous solution to granulate the mixture, and drying the mixture to obtain water-dispersible granules.

[0084] Example 6 Water Dispersible Granules

[0085] Pendimethalin 28%, metamifop 6%, sodium p-hydroxyphenyl lignin sulfonate 5%, triphenyl phenol polyoxyethylene ether 5%, carboxymethyl cellulose 4%, sodium sulfate 4%, and kaolin as the balance.

[0086] The preparation method is the same as Example 5.

[0087] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition, characterized in that The active ingredients of the composition include pendimethalin and metamifop, and the weight ratio of pendimethalin to metamifop is 1-10:

1.

2. The composition according to claim 1, characterized in that The weight ratio of pendimethalin to metamifop is preferably 2-5:

1.

3. The composition according to claim 1, characterized in that The active ingredients of the composition further include a third active ingredient.

4. The composition according to claim 3, characterized in that The third active ingredient is preferably propanil.

5. The composition according to claim 3 or 4, characterized in that The weight ratio of pendimethalin, metamifop and the third active ingredient is 1-10:1:2-15.

6. The composition according to any one of claims 1 to 5, characterized in that The composition further comprises agriculturally acceptable adjuvants and / or carriers and is prepared into conventional agricultural formulations.

7. The composition according to claim 6, characterized in that The agriculturally acceptable adjuvant and / or carrier includes one or more of a solvent, a surfactant, a thickener, an antifreeze agent, a binder, a disintegrant, a defoaming agent, a filler and / or a carrier.

8. The composition according to any one of claims 1 to 7, characterized in that The total weight percentage of active ingredients in the composition is 5-60%.

9. Use of the composition according to any one of claims 1 to 8 for controlling agricultural weeds.

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