Composite whitening composition as well as preparation method and application thereof

Abstract

The invention relates to a composite whitening composition and a preparation method and application thereof.The composition comprises raspberry ketone glucoside and surfactin, the raspberry ketone glucoside and the surfactin are compounded in a scientific proportion according to the mechanism that the raspberry ketone glucoside and the surfactin act on different whitening targets in the melanin generation process, the brightening and whitening effects can be remarkably improved, and the whitening effect can be remarkably improved. The whitening effect is far better than that of a conventional whitening agent. And the raspberry ketone glucoside and the surfactin have simple structures, are mild and safe, and do not generate risky substances.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composite whitening composition, a preparation method and an application thereof. Background Art

[0002] The skin is the largest organ in the human body, located on the surface of the body and in direct contact with the external environment. It performs functions such as protection, excretion, temperature regulation, and sensing external stimuli. The skin is divided into three parts: the epidermis, dermis, and subcutaneous tissue. The epidermis is primarily composed of keratinocytes, melanocytes, Langerhans cells, and Merkel cells. Melanocytes, primarily located in the basal layer of the epidermis, produce melanin and transfer it to surrounding keratinocytes. Melanin resides in the nuclei of these keratinocytes, protecting chromosomes from damage caused by light radiation. However, modern people consider fair skin a hallmark of beauty, leading to an increasing demand for skin whitening products.

[0003] Traditional whitening agents, such as arbutin, niacinamide, and vitamin C derivatives, have a melanin-improving effect. However, most current whitening agents target tyrosinase activity, thereby inhibiting melanin production. However, inhibiting this single target alone has limited whitening effects and fails to minimize melanin production. Summary of the Invention

[0004] In view of this, the present application provides a composite whitening composition that can reduce the degree of reaction in the melanin production process from multiple targets including inhibiting tyrosinase activity, scavenging oxygen free radicals, stabilizing dopachrome and inhibiting the activity of dopachrome isomerase, thereby reducing the amount of melanin produced and whitening and brightening the skin.

[0005] A composite whitening composition comprises raspberry glycosides and Aobaiting.

[0006] According to one aspect of the present application, the amount of raspberry glycosides is 0.1-20 parts, and the amount of Aobaiting is 0.1-1 part.

[0007] According to one aspect of the present application, the ratio of the raspberry glycosides to the Aobaiting is 1-20:1.

[0008] According to one aspect of the present application, the ratio of the raspberry glycosides to the Aobaiting is 3-15:1.

[0009] According to one aspect of the present application, the ratio of the raspberry glycosides to the Aobaiting is 6-10:1.

[0010] A method for preparing a whitening composition comprises the following steps: S1: first, raspberry ketone and glucose are combined through a glycosidic bond to generate raspberry glycoside; S2: then, an amino acid molecule and a hypophosphorous acid molecule are combined through a covalent bond to generate a small molecule amino acid component, namely, Aobaiting; S3: raspberry glycoside and Aobaiting are added into a reactor and stirred to mix to obtain the whitening composition.

[0011] According to one aspect of the present application, the ratio of the raspberry glycosides to the Aobaiting is 1-20:1 and 3-15:1.

[0012] According to one aspect of the present application, the ratio of the raspberry glycosides to the Aobaiting can also be 6-10:1.

[0013] A whitening cosmetic comprises the above-mentioned whitening composition, wherein the mass of the whitening composition accounts for 0.01-10% of the total mass of the whitening cosmetic.

[0014] According to one aspect of the present application, one or more of moisturizers, antioxidants, whitening agents and skin conditioning agents are further included.

[0015] The beneficial effects of the present invention are as follows: The combination of the two components of the composite whitening composition can reduce the degree of melanin production by inhibiting tyrosinase activity, scavenging oxygen free radicals, stabilizing dopachrome, and inhibiting the activity of dopachrome isomerase, thereby reducing melanin production and whitening and brightening the skin. Furthermore, both components are naturally derived, have simple structures, and are safe and natural, without irritation or safety issues, making them very suitable for sensitive skin. DETAILED DESCRIPTION

[0016] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0017] Unless otherwise specified, the experimental methods used in the following examples are generally based on conventional conditions. Unless otherwise specified, the materials and reagents used in the following examples are all commercially available.

[0018] A composite whitening composition, comprising raspberry glycoside and Aobaiting. Raspberry glycoside is derived from raspberry fruit and is a component generated by the glycosidic bond between raspberry ketone and glucose. Its whitening mechanism has two pathways and multiple targets acting simultaneously. On the one hand, tyrosinase is a bifunctional polyphenol oxidase (PPO). The tyrosinase active center presents a binuclear copper center structure, consisting of two copper ion sites, which bind to histidine residues in proteins, and an endogenous bridge connects the two copper ions. The active site of tyrosinase is two copper atoms and activates oxygen molecules, causing the reactant tyrosine to bind to oxygen, an oxidation reaction to occur, and then a subsequent series of reactions to produce melanin. Therefore, raspberry glycoside can inhibit / react the oxygen molecules activated by tyrosinase, prevent the oxidation reaction catalyzed by tyrosinase, and inhibit tyrosinase activity. Secondly, under the influence of factors such as ultraviolet radiation, hormonal changes, inflammation, stress, and environmental pollution, stable oxygen atoms in the skin can lose an electron, transforming harmless oxygen into lethal reactive oxygen free radicals. This leads to oxidation reactions, which in turn produce reactive oxygen species, lipid peroxides, and nitric oxide, contributing to aging and inflammatory melanin. Raspberry glycosides can scavenge and eliminate reactive oxygen free radicals, reducing them to stable oxygen, reducing the oxidative reactions caused by reactive oxygen species in the skin, thereby reducing melanin and brightening the skin. Aobaiting is a small amino acid molecule covalently bonded to a hypophosphorous acid molecule. Aobaiting's small molecular weight allows for efficient absorption and utilization upon application to the skin surface, resulting in high bioavailability and a significant effect even at low concentrations. Aobaiting's whitening mechanism is by stabilizing dopachrome during melanin synthesis and inhibiting the activity of dopachrome isomerase, thereby preventing dopachrome polymerization and reducing melanin production.

[0019] Preferably, the amount of raspberry glycosides is 0.1-20 parts, and the amount of Aobaiting is 0.1-1 part.

[0020] Preferably, the ratio of the raspberry glycosides to the Aobaiting is 1-20:1.

[0021] Preferably, the ratio of the raspberry glycosides to the Aobaiting is 3-15:1.

[0022] Preferably, the ratio of the raspberry glycosides to the Aobaiting is 6-10:1.

[0023] The present invention also provides a method for preparing a whitening composition, comprising the following steps: S1: first, raspberry ketone and glucose are combined through a glycosidic bond to generate raspberry glycoside; S2: then, an amino acid molecule and a hypophosphorous acid molecule are combined through a covalent bond to generate a small molecule amino acid component, which is Aobaiting; S3: raspberry glycoside and Aobaiting are put into a reactor and stirred to mix to obtain a whitening composition.

[0024] The more specific steps of preparing raspberry glycosides are:

[0025] First, glucose, acetic anhydride and anhydrous sodium acetate are subjected to an esterification reaction to obtain pentaacetyl glucose; then, a solvent, raspberry ketone and a catalyst are added to the pentaacetyl glucose to carry out a condensation reaction to obtain a semi-finished product; then, a solvent and a catalyst are added to the semi-finished product to obtain crude raspberry glycoside; finally, the crude raspberry glycoside is separated and refined to obtain the required raspberry glycoside.

[0026] The more specific steps for preparing Aobaiting are:

[0027] First, diphenylmethylamine, hypophosphorous acid and acetaldehyde are subjected to a synthesis reaction, and then crystallized and filtered, and then inorganic acid is added to obtain a semi-finished product; after the semi-finished product is concentrated to dryness, ethanol is added, and after separation and purification, the required Aobaiting is obtained.

[0028] Preferably, in the aforementioned preparation method, the ratio of the raspberry glycosides to the Aobaiting is 1-20:1 and 3-15:1.

[0029] Preferably, in the aforementioned preparation method, the ratio of the raspberry glycosides to the Aobaiting can also be 6-10:1.

[0030] The present invention also provides a whitening cosmetic comprising the above-mentioned whitening composition, wherein the mass proportion of the whitening composition accounts for 0.01-10% of the total mass of the whitening cosmetic.

[0031] According to one aspect of the present application, the composite whitening composition further comprises one or more of a moisturizer, an antioxidant, a whitening agent, and a skin conditioning agent. The composite whitening composition disclosed in the present invention is a cosmetic raw material and can also be used as a cosmetic.

[0032] The composite whitening composition disclosed in the present invention can be made into different types of cosmetics with different types of cosmetic raw materials. For example, the composite whitening composition disclosed in the present invention can be mixed with conventional basic ingredients for making lotion cosmetics to obtain a lotion with whitening function; the composite whitening composition disclosed in the present invention can be mixed with conventional basic ingredients for making gel cosmetics to obtain a gel cosmetic with whitening function; the composite whitening composition disclosed in the present invention can be mixed with conventional basic ingredients for making emulsion cosmetics to obtain an emulsion cosmetic with whitening function; and the composite whitening composition disclosed in the present invention can be mixed with conventional basic ingredients for making cream cosmetics to obtain a cream cosmetic with whitening function. It is worth noting that the moisturizing, firming and anti-wrinkle composition disclosed in the present invention includes but is not limited to the preparation of the above-mentioned types of cosmetics.

[0033] It is worth noting that when preparing water-based and gel-based cosmetics, the temperature needs to be lowered to 45°C before the composite whitening composition disclosed in the present invention can be added; when preparing milk-based and cream-based cosmetics, heating and emulsification are required, and the whitening composition disclosed in the present invention can only be added when the temperature drops below 45°C.

[0034] The present invention will be further described below with reference to specific embodiments, but this should not be construed as limiting the scope of protection of the present invention. Non-essential improvements and adjustments made to the present invention by those skilled in the art based on the above-mentioned contents of the present invention still fall within the scope of protection of the present invention.

[0035] Unless otherwise specified, the materials and reagents mentioned below are commercially available products familiar to those skilled in the art. Unless otherwise specified, the methods described are all well-known methods in the art. Unless otherwise defined, technical or scientific terms used shall have the same meanings as those commonly understood by those skilled in the art.

[0036] Example 1

[0037] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 3% of a composite whitening composition, 2.5% of a moisturizer, 0.5% of an antioxidant, and 94% of conventional basic ingredients for preparing whitening lotions; the composite whitening composition comprises, by weight, 15 parts, i.e., 2.812 g, of raspberry glycosides and 1 part, i.e., 0.188 g, of Aobating.

[0038] The specific steps include:

[0039] S1: 15 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0040] S2: Add 3% of the composite whitening composition, 2.5% of the moisturizer, 0.5% of the antioxidant and 94% of the conventional basic ingredients for preparing whitening lotion into a reaction kettle, stir evenly and dissolve completely to obtain the finished whitening lotion.

[0041] Example 2

[0042] A whitening gel, calculated per 100 g, comprises, by mass percentage, 4% of a composite whitening composition, 2.5% of a moisturizer, 0.5% of an antioxidant, and 93% of conventional basic ingredients for preparing gel cosmetics; the composite whitening composition comprises, by weight, 10 parts, or 3.636 g, of raspberry glycosides and 1 part, or 0.364 g, of Aobating.

[0043] The specific steps include:

[0044] S1: 10 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0045] S2: 4% of the composite whitening composition, 2.5% of the moisturizer, 0.5% of the antioxidant and 93% of the conventional basic ingredients for preparing gel cosmetics are added into a reaction kettle, stirred evenly and dissolved completely to obtain a finished whitening gel product.

[0046] Example 3

[0047] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 8 parts, i.e. 4.444 g, of raspberry glycosides and 1 part, i.e. 0.556 g, of Aobating.

[0048] The specific steps include:

[0049] S1: 8 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0050] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0051] Example 4

[0052] A whitening cream, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 79% conventional basic ingredients for preparing cosmetics, 6% composite whitening composition and 12% water; the composite whitening composition comprises, by weight, 6 parts, i.e. 5.143 g, of raspberry glycosides and 1 part, i.e. 0.857 g, of Aobating.

[0053] The specific steps include:

[0054] S1: 6 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0055] S2: 2.5% moisturizer, 0.5% antioxidant, 79% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 6% composite whitening composition is pre-dissolved in 12% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0056] Example 5

[0057] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 3 parts, i.e. 3.750 g, of raspberry glycosides and 1 part, i.e. 1.250 g, of Aobaiting.

[0058] The specific steps include:

[0059] S1: 3 parts of raspberry glycosides and 1 part of Aobaiting were mixed to obtain a composite whitening composition;

[0060] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0061] Example 6

[0062] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 1 part, i.e. 2.50 g, of raspberry glycosides and 1 part, i.e. 2.50 g, of Aobating.

[0063] The specific steps include:

[0064] S1: Mixing 1 part of raspberry glycosides and 1 part of Aobaiting to obtain a composite whitening composition;

[0065] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0066] Example 7

[0067] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 10 parts, i.e. 4.545 g, of raspberry glycosides and 1 part, i.e. 0.455 g, of Aobating.

[0068] The specific steps include:

[0069] S1: 10 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0070] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0071] Example 8

[0072] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 15 parts, i.e. 4.688 g, of raspberry glycosides and 1 part, i.e. 0.313 g, of Aobating.

[0073] The specific steps include:

[0074] S1: 15 parts of weighed raspberry glycosides and 1 part of Aobaiting are stirred and mixed to obtain a composite whitening composition; S2: 2.5% moisturizer, 0.5% antioxidant, 82% of the conventional basic ingredients for preparing cosmetics, oil phase and water phase are added to a reactor and heated and emulsified, 5% of the composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0075] Example 9

[0076] A whitening lotion, calculated per 100 g, comprises, by mass percentage: 2.5% moisturizer, 0.5% antioxidant, 82% conventional basic ingredients for preparing cosmetics, 5% composite whitening composition and 10% water; the composite whitening composition comprises, by weight, 20 parts, i.e. 4.762 g, of raspberry glycosides and 1 part, i.e. 0.238 g, of Aobating.

[0077] The specific steps include:

[0078] S1: 20 parts of raspberry glycosides and 1 part of Aobaiting were weighed and mixed to obtain a composite whitening composition;

[0079] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% composite whitening composition is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a whitening emulsion.

[0080] Example 10

[0081] Compared with Example 3, the composite whitening composition of Example 9 includes 0.1 parts, i.e. 4.545 g, of raspberry glycosides and 1 part, i.e. 0.455 g, of Aobaiting, in parts by weight.

[0082] Example 11

[0083] Compared with Example 3, the composite whitening composition of Example 10 includes 20 parts, i.e. 4.975 g, of raspberry glycosides and 0.1 parts, i.e. 0.025 g, of Aobaiting, in parts by weight.

[0084] Comparative Example 1

[0085] A whitening lotion comprises, by mass percentage, 3% of a conventional whitening agent, 2.5% of a moisturizing agent, 0.5% of an antioxidant, and 94% of conventional basic ingredients for preparing whitening lotions, wherein the 3% conventional whitening agent is niacinamide.

[0086] The specific steps include:

[0087] 3% conventional whitening agent, 2.5% moisturizer, 0.5% antioxidant and 94% conventional basic ingredients for preparing whitening cosmetics are added into a reactor, stirred evenly and dissolved completely to obtain a finished whitening lotion.

[0088] Comparative Example 2

[0089] A whitening gel comprising, by mass percentage, 4% of a conventional whitening agent, 2.5% of a moisturizing agent, 0.5% of an antioxidant, and 93% of conventional basic ingredients for preparing whitening lotions, wherein the 4% conventional whitening agent is a 1:1 ratio of niacinamide to arbutin.

[0090] The specific steps include:

[0091] S1: Mixing 1 part of niacinamide and 1 part of arbutin to obtain a composite whitening composition;

[0092] S2: Add 4% of conventional whitening agent, 2.5% of moisturizing agent, 0.5% of antioxidant and 93% of conventional basic ingredients for preparing gel cosmetics into a reactor, stir evenly and dissolve completely to obtain a finished whitening gel product.

[0093] Comparative Example 3

[0094] A whitening lotion comprising, by mass percentage, 5% conventional whitening agent, 2.5% moisturizer, 0.5% antioxidant, 82% conventional base ingredients used in cosmetics, and 10% water. The 5% conventional whitening agent is niacinamide:tranexamic acid in a ratio of 3:2.

[0095] The specific steps include:

[0096] S1: 3 parts of niacinamide and 2 parts of tranexamic acid were weighed and stirred to obtain a conventional whitening composition;

[0097] S2: 2.5% moisturizer, 0.5% antioxidant, 82% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 5% conventional whitening agent is pre-dissolved in 10% water, added to the reactor and stirred evenly to obtain a finished whitening emulsion.

[0098] Comparative Example 4

[0099] A whitening cream comprising, by mass percentage, 6% conventional whitening agent, 2.5% moisturizer, 0.5% antioxidant, 79% conventional base ingredients for preparing cosmetics, and 12% water, wherein the 6% conventional whitening agent is niacinamide:arbutin in a 1:1 ratio.

[0100] The specific steps include:

[0101] S1: Mixing 1 part of niacinamide and 1 part of arbutin to obtain a conventional whitening composition;

[0102] S2: 2.5% moisturizer, 0.5% antioxidant, 79% oil phase and water phase of conventional basic ingredients for preparing cosmetics are added to a reactor and heated for emulsification. 6% conventional whitening agent is pre-dissolved in 12% water, added to the reactor and stirred evenly to obtain the finished whitening cream.

[0103] Whitening effect experiment of the present invention

[0104] Female volunteers aged 25-55 years with mixed or normal skin, tending towards darker skin, and an ITA° value of 28-43. The difference in ITA° between the pigmented area and the surrounding skin was greater than 10. Ten volunteers were divided into groups and applied samples prepared in the Examples and Comparative Examples to the pigmented areas every morning and evening for one month. The initial and final L, a, and b values ​​were measured for each volunteer, and the rate of change in L value and ITA° was calculated.

[0105] The higher the L value, the whiter the skin. The larger the ITA° value, the brighter the skin. A significant increase in the L and ITA° values ​​indicates a significant whitening effect.

[0106] The test results are shown in Tables 1 and 2 below.

[0107] Table 1, L value change rate (average value):

[0108] sample L value change rate (%) sample L value change rate (%) Example 1 4.9 Comparative Example 1 0.7 Example 2 7.4 Comparative Example 2 1.8 Example 3 9.9 Comparative Example 3 3.1 Example 4 11.2 Comparative Example 4 5.8 Example 5 8.8 Example 6 8.0 Example 7 10.8 Example 8 9.1 Example 9 8.5 Example 10 10.5 Example 11 5.8

[0109] Table 2, ITA° value change rate (average value):

[0110]

[0111]

[0112] From the above test results, it can be seen that the cosmetics prepared using the composite whitening composition of the present invention have significant brightening and whitening effects, which are significantly higher than the whitening effect of the comparative example, and as the addition amount of the composite whitening composition increases, the whitening and brightening effects also increase.

[0113] When adding a composite whitening composition, increasing the dosage helps increase the rate of change in L value and ITA° value, enhancing both brightening and whitening efficacy. When adding 5% of the same composite whitening composition, varying the ratio of raspberry glycosides to Aobaiting has a certain impact on the rate of change in L value and ITA° value. A ratio of 6-10:1 of raspberry glycosides to Aobaiting achieves the best brightening and whitening effects.

[0114] The best specific implementation method, but the protection scope of the present invention is not limited to this. Any technician familiar with the technical field, within the scope disclosed by the present invention, can make equivalent replacements or changes based on the technical solutions and concepts of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A composite whitening composition, characterized in that: The composition comprises raspberry glycosides and Aobaiting.

2. The composite whitening composition according to claim 1, characterized in that The amount of the raspberry glycoside is 0.1-20 parts, and the amount of the Aobaiting is 0.1-1 part.

3. The composite whitening composition according to claim 2, characterized in that The ratio of the raspberry glycosides to the Aobaiting is 1-20:

1.

4. The composite whitening composition according to claim 2, characterized in that The ratio of the raspberry glycosides to the Aobaiting is 3-15:

1.

5. The composite whitening composition according to claim 2, characterized in that The ratio of the raspberry glycosides to the Aobaiting is 6-10:

1.

6. A method for preparing a composite whitening composition, characterized in that: The following steps are involved: S1: First, raspberry ketone and glucose combine through glycosidic bonds to form raspberry glycoside; S2: Furthermore, an amino acid molecule and a hypophosphorous acid molecule are combined through a covalent bond to generate a small molecule amino acid component, which is Aobaiting; S3: Put raspberry glycosides and Aobaiting into a reactor and stir and mix them to obtain a whitening composition.

7. The method for preparing the composite whitening composition according to claim 6, wherein: The ratio of the raspberry glycoside to the Aobaiting is 1-20:1 and 3-15:

1.

8. The method for preparing the composite whitening composition according to claim 6, wherein: The ratio of the raspberry glycosides to the Aobaiting can also be 6-10:

1.

9. A whitening cosmetic, characterized in that: The whitening composition comprises the whitening composition according to any one of claims 1 to 5, wherein the mass of the whitening composition accounts for 0.01-10% of the total mass of the whitening cosmetic.

10. The whitening cosmetic according to claim 9, characterized in that Also included are one or more of moisturizers, antioxidants, whitening agents, and skin conditioning agents.

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