Composition with soothing effect, preparation scheme of composition and application of cosmetic

Abstract

The invention provides a composition with a soothing effect, a preparation scheme of the composition and application of cosmetics. The composition comprises the following components in percentage by mass: 35-50% of actinidia chinensis fruit water, 2-10% of a radix gentianae extract, 1-9% of a citron fruit extract, 1-4% of a dendrobium stem extract, 1-5% of an oat extract and the balance of butanediol. All the components in the composition cooperate with one another, the multi-dimensional synergistic effect of resisting inflammation, resisting histamine, repairing a barrier, resisting oxidation and adjusting micro-ecology can be achieved, and the composition has the excellent relieving effect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with soothing effect, a preparation method thereof, and application of the composition in cosmetics. Background Art

[0002] In today's society, with changes in environmental factors, increased stress in life, and improper use of cosmetics, more and more people are facing problems such as skin sensitivity and redness. Sensitive skin is characterized by impaired skin barrier function, reduced tolerance to external stimuli, and is prone to symptoms such as redness, itching, and stinging. Although there are many types of soothing products on the market, most of them have problems such as single efficacy, insignificant effect, and poor ingredient safety. Some products only focus on anti-inflammatory or antihistamine effects and cannot solve the problem of sensitive skin from multiple dimensions; the chemical ingredients used in some products may have potential irritation to the skin, and long-term use may also cause other skin problems. Therefore, the development of a safe, efficient, multi-dimensional synergistic composition with excellent soothing effect and its preparation method, and its application in cosmetics, has important practical significance and broad market prospects. Summary of the Invention

[0003] The present invention aims to provide a soothing composition that, through the synergistic combination of its components, achieves multi-dimensional synergistic effects of anti-inflammatory, antihistamine, antioxidant, and microecological regulation, thereby effectively solving the problem of skin sensitivity and redness. The present invention also provides a simple and efficient method for preparing the composition, which can effectively retain the active ingredients of each component and promote the development of soothing compositions. Furthermore, the present invention also applies the composition to cosmetics to provide safe and effective skin care products for people with sensitive skin.

[0004] A composition with soothing effect comprises the following components in the following mass percentages: 35-50% of Chinese kiwi fruit water, 2-10% of gentian root extract, 1-9% of citron fruit extract, 1-4% of dendrobium nobile stem extract, 1-5% of oat extract and the balance of butylene glycol.

[0005] Optionally, the mass percentage of the Chinese kiwi fruit water is 42-46%.

[0006] Optionally, the mass percentage of the gentian root extract is 4-7%.

[0007] Optionally, the mass percentage of the citron fruit extract is 4-6%.

[0008] Optionally, the mass percentage of the Dendrobium nobile stem extract is 2.5-3.5%.

[0009] Optionally, the mass percentage of the oat extract is 2-3%.

[0010] The preparation method of the above-mentioned composition with soothing effect comprises the following steps:

[0011] S1: Juice the Chinese kiwi fruit, citron fruit, Dendrobium nobile stem and oats and filter to obtain a filtrate and a filter residue.

[0012] S2: The filter residue obtained in S1 is mixed with gentian root, and water is added to perform vacuum ultrasonic extraction. The extract is concentrated and then processed through a chromatography column, and then eluted. The obtained eluate is concentrated and dried to obtain a mixture;

[0013] S3: The mixture obtained in S2 and the filtrate obtained in S1 are mixed with butanediol.

[0014] A cosmetic comprising the above-mentioned composition with soothing effect.

[0015] Optionally, the mass percentage of the composition with soothing effect in the cosmetic is 0.1-7%.

[0016] Beneficial effects

[0017] This formula rapidly alleviates symptoms of sensitive skin, such as redness, burning, and itching, through its multi-dimensional, synergistic effects of anti-inflammatory, antihistamine, antioxidant, and microbiome regulation. It also addresses the root causes of skin sensitivity and improves skin tolerance. Each ingredient complements its own target (such as inflammatory pathways, vascular function, barrier structures, and immune responses), ultimately achieving a highly effective soothing effect. DETAILED DESCRIPTION

[0018] One embodiment of the present invention provides a soothing composition. The composition comprises the following components in percentage by weight: 35-50% Actinidia chinensis fruit water, 2-10% Gentiana root extract, 1-9% Citron fruit extract, 1-4% Dendrobium nobile stem extract, 1-5% Avena sativa extract, and the balance butylene glycol. Through the synergistic effects of these components, the composition achieves multi-dimensional synergistic effects of anti-inflammatory, antihistamine, antioxidant, and microbiome regulation, effectively addressing skin sensitivity and redness.

[0019] Chinese kiwifruit juice is rich in vitamin C and polyphenols. Vitamin C has antioxidant properties, scavenging free radicals, reducing oxidative damage caused by inflammation, and alleviating skin redness. Polyphenols inhibit histamine release, reduce vascular permeability, and alleviate erythema and edema caused by allergies. Furthermore, vitamin C can boost the activity of immune cells (such as white blood cells), enhancing the skin's ability to resist external stimuli and reducing immune responses to allergens.

[0020] Gentiana root extract contains active ingredients such as gentiopicroside. Gentiana picroside has significant anti-inflammatory properties. By inhibiting Toll receptor signaling, it inhibits the inflammasome NLRP3, blocks the NF-kB pathway, and reduces the expression of pro-inflammatory cytokines (such as TNF-α and IL-6), thereby alleviating skin inflammation and redness. It also has antibacterial and soothing effects, inhibiting pathogenic bacteria such as Staphylococcus aureus, reducing the risk of skin infections. It can also soothe burning and itching sensations in sensitive skin.

[0021] Citron fruit extract contains citronellal, flavonoids, and volatile oils. Flavonoids (such as hesperidin) can enhance vascular elasticity and improve redness caused by capillary dilation by downregulating the JAK-STAT pathway, inhibiting the chemokine-induced NF-kB pathway, and suppressing the production of inflammatory factors. Furthermore, they inhibit VEGF, which in turn reduces redness caused by capillary dilation. Volatile oils have antibacterial and soothing effects, alleviating inflammatory responses. They also regulate the skin's microbiome, inhibiting the growth of harmful bacteria, maintaining a balanced skin flora, and reducing allergies caused by dysbiosis.

[0022] The synergistic effect of polysaccharides and dendrobium alkaloids in the stem extract of Dendrobium nobile. The polysaccharide component promotes skin cell proliferation, blocks the binding of IL-17 to TNF receptors, inhibits skin tissue damage caused by MMP, and resists skin barrier damage. It can also inhibit TGF-β from activating smad protein phosphorylation, reduce collagen fibrosis, inhibit scar cells, and accelerate scar repair. Accelerate the repair of damaged barriers; dendrobium alkaloids have anti-inflammatory activity, which can inhibit the synthesis of inflammatory mediators (such as prostaglandin E2), relieve skin redness and burning sensation, and have antioxidant and moisturizing effects. They can scavenge free radicals and reduce oxidative stress damage to the skin; at the same time, they enhance the skin's water retention capacity and improve the dryness and desquamation problem of sensitive skin.

[0023] In oat extract, oat amides inhibit NF-KB and COX-2, reduce IL-6 and IL-8, and improve skin redness. They also inhibit the release of histamine from mast cells, blocking its binding to H1 receptors, relieving itchy skin. They also scavenged free radicals (such as DPPH and ABTS) and reduced oxidative stress damage to the skin. Butylene glycol acts as a solvent and a penetration enhancer. As a solvent, it helps dissolve other active ingredients, ensuring formula stability; it also has a slight penetration enhancer effect, enhancing the skin's absorption efficiency of active ingredients. Butylene glycol also has a moisturizing effect: as a small molecule alcohol, it absorbs water, maintains skin hydration, and reduces the decline in barrier function caused by dryness.

[0024] A good synergistic mechanism can be formed between the above components:

[0025] (1) Multi-pathway anti-inflammatory

[0026] Gentiana root extract inhibits the NF-κB inflammatory pathway, Chinese kiwi fruit water scavenges free radicals and reduces oxidative stress, and Dendrobium nobile stem extract inhibits prostaglandin synthesis. The three block the inflammatory response from different links and enhance the anti-inflammatory effect.

[0027] (2) Antihistamine and vascular protection

[0028] The flavonoids in citron fruit extract enhance vascular elasticity, while Chinese kiwi fruit water reduces vascular permeability. The two work together to reduce erythema, edema and itching caused by allergies.

[0029] (3) Microecological balance and anti-oxidation

[0030] Citron fruit extract regulates the bacterial flora and reduces inflammation caused by harmful bacteria; the antioxidant components of Chinese kiwi fruit water and Dendrobium nobile stem extract scavenge free radicals, reduce inflammation-related oxidative damage, and form an anti-inflammatory-antioxidant cycle.

[0031] In some embodiments, the mass percentage of the kiwifruit juice is 42-46%. For example, the mass percentage of the kiwifruit juice can be 35%, 38%, 40%, 42%, 44%, 46%, 50%, etc.

[0032] In some embodiments, the mass percentage of the gentian root extract is 4-7%.For example, the mass percentage of the gentian root extract can be 2%, 3%, 4%, 5%, 7%, 8%, 10%, etc.

[0033] In some embodiments, the mass percentage of citron fruit extract is 4-6%. For example, the mass percentage of citron fruit extract can be 1%, 3%, 4%, 5%, 6%, 8%, 9%, etc.

[0034] In some embodiments, the mass percentage of the Dendrobium nobile stem extract is 2.5-3.5%. For example, the mass percentage of the Dendrobium nobile stem extract can be 1%, 2%, 3%, 3.5%, 4%, etc.

[0035] In some embodiments, the mass percentage of oat extract is 2-3%.For example, the mass percentage of oat extract can be 2%, 2.2%, 2.5%, 2.8%, 3%, etc.

[0036] When the mass percentage of Chinese kiwifruit water is 42-46%, it can better synergize with other ingredients while ensuring a sufficient supply of antioxidant and anti-inflammatory ingredients. At a mass percentage of gentian root extract of 4-7%, the anti-inflammatory and antihistamine effects are more pronounced, achieving a better balance between the skin barrier repair effect and the anti-inflammatory, antioxidant, and antipruritic effects. At a mass percentage of citron fruit extract of 4-6%, the regulation of skin microecological balance and the antioxidant and anti-inflammatory effects are more prominent. At a mass percentage of Dendrobium nobile stem extract of 2.5-3.5%, its promotion of skin cell repair and regeneration and antioxidant effects are more effectively exerted. At these preferred mass percentages, the antioxidant and anti-inflammatory effects of Chinese kiwifruit water can better complement the anti-inflammatory and antihistamine effects of Gentiana root extract, jointly alleviating skin inflammation and allergic reactions. The effects of Dendrobium nobile stem extract in promoting skin cell repair and regeneration synergistically accelerate the recovery of the skin barrier. The effect of citron fruit extract in regulating the balance of skin microecology works synergistically with the anti-inflammatory and antioxidant effects of other ingredients to create a good ecological environment for the skin, thereby further enhancing the soothing effect of the entire composition.

[0037] Another embodiment of the present invention provides a method for preparing the above-mentioned composition with soothing effect, comprising the following steps:

[0038] S1: Juice is squeezed from Actinidia chinensis fruit, Citron fruit, Dendrobium nobile stem and oats, and the juice is filtered to obtain a filtrate and a filter residue.

[0039] S2: The filter residue obtained in S1 is mixed with the gentian root and water is added to perform vacuum ultrasonic extraction. The extract is concentrated and then processed through a chromatography column, and then eluted. The obtained eluate is concentrated and dried to obtain a mixture.

[0040] S3: The mixture obtained in S2 and the filtrate obtained in S1 are mixed with butanediol.

[0041] Another embodiment of the present invention provides a cosmetic comprising the above-mentioned composition with soothing effect.

[0042] Optionally, the mass percentage of the composition with soothing effect in the cosmetic is 0.1-7%.

[0043] Optionally, the cosmetic can be lotion, cream, essence, or facial mask.

[0044] Example 1

[0045] The method for preparing the composition with soothing effect in this embodiment comprises the following steps:

[0046] S1: Juice is squeezed from Actinidia chinensis fruit, Citron fruit, Dendrobium nobile stem and oats, and the juice is filtered to obtain a filtrate and a filter residue.

[0047] S2: The filter residue obtained in S1 is mixed with the gentian root and water is added to perform vacuum ultrasonic extraction. The extract is concentrated and then processed through a chromatography column, and then eluted. The obtained eluate is concentrated and dried to obtain a mixture.

[0048] S3: The mixture obtained in S2 and the filtrate obtained in S1 are mixed with butanediol.

[0049] Examples 2-5, Comparative Examples 1-2

[0050] Compared with Example 1, the difference between Examples 2-5 and Comparative Examples 1-2 is that the mass percentages of the components in the compositions are different, as shown in Table 1.

[0051] Test Case

[0052] (1) Anti-inflammatory performance test: An in vitro cell inflammation model was used to induce an inflammatory response in RAW264.7 macrophages using lipopolysaccharide (LPS). The anti-inflammatory performance of the composition was evaluated by detecting the content of inflammatory factors (such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)) in the cell culture supernatant. The lower the content of inflammatory factors, the better the anti-inflammatory performance. The results are shown in Table 1.

[0053] (2) Antihistamine Activity Test: A rat peritoneal mast cell degranulation assay was used to test the inhibitory effect of the composition on histamine release from rat peritoneal mast cells. Lower histamine release indicates better antihistamine activity. The results are shown in Table 1.

[0054] (3) Antioxidant performance test: 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) free radical scavenging test was used. The higher the free radical scavenging rate, the better the antioxidant performance. The results are shown in Table 1.

[0055] (4) Skin Microecological Regulation Performance Test: Using a microbial culture method, the composition was tested for its inhibitory effect on common harmful bacteria on the skin (e.g., Staphylococcus aureus) and its promoting effect on beneficial bacteria (e.g., Staphylococcus epidermidis). The results are shown in Table 1.

[0056] Table 1

[0057]

[0058]

[0059] It is understood that in Table 1, the sum of the mass percentages of the components in the composition is 100%.

[0060] As can be seen from Table 1, the composition in the example shows better performance in anti-inflammatory, antihistamine, antioxidant and skin microecology regulation than the comparative example.

[0061] (5) The soothing efficacy of the composition in Example 1 was tested based on transcriptome sequencing technology. The test group consisted of the composition in Example 1 + LPS + culture medium, with a composition mass concentration of 0.5%. The blank group consisted of culture medium. The model control group consisted of LPS + culture medium. The test results are shown in Table 2. It is understood that the test results of the model control group were all 1.00 and are not shown in Table 2.

[0062] Table 2

[0063]

[0064]

[0065] As can be seen from Table 2, the composition in Example 1 can block the NF-κB pathway, inhibit the JAK-STAT pathway, and inhibit TGF-β fibrosis, thereby enabling the composition to exhibit good soothing effects.

[0066] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

[0067] For those skilled in the art, according to the concept of the present invention, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A composition with soothing effect, characterized in that The invention comprises the following components in the following mass percentages: 35-50% of Chinese kiwi fruit water, 2-10% of gentian root extract, 1-9% of citron fruit extract, 1-4% of dendrobium nobile stem extract, 1-5% of oat extract and the balance of butylene glycol.

2. The soothing composition according to claim 1, wherein The mass percentage of the Chinese kiwi fruit water is 42-46%.

3. The composition with soothing effect according to claim 1, characterized in that The mass percentage of the gentian root extract is 4-7%.

4. The composition with soothing effect according to claim 1, wherein The mass percentage of the citron fruit extract is 4-6%.

5. The composition with soothing effect according to claim 1, characterized in that The mass percentage of the Dendrobium nobile stem extract is 2.5-3.5%.

6. The composition with soothing effect according to any one of claims 1 to 5, characterized in that The mass percentage of the oat extract is 2-3%.

7. The method for preparing the composition with soothing effect according to any one of claims 1 to 6, characterized in that: The steps include: S1: Juice the Chinese kiwi fruit, citron fruit, Dendrobium nobile stem and oats and filter to obtain a filtrate and a filter residue. S2: The filter residue obtained in S1 is mixed with gentian root, and water is added to perform vacuum ultrasonic extraction. The extract is concentrated and then processed through a chromatography column, and then eluted. The obtained eluate is concentrated and dried to obtain a mixture; S3: The mixture obtained in S2 and the filtrate obtained in S1 are mixed with butanediol.

8. A cosmetic, characterized in that: The invention comprises the composition with soothing effect according to any one of claims 1 to 6.

9. The cosmetic according to claim 8, wherein The mass percentage of the composition with soothing effect in the cosmetic is 0.1-7%.

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