Composition with moisturizing and anti-saccharification effects and preparation method thereof

Abstract

The invention provides a composition with moisturizing and anti-saccharification effects, and the composition comprises the following components: 70-85 parts of water, 8-12 parts of butanediol, 0.2-0.3 part of a tremella sporocarp extract, 1-3 parts of a Japanese yam root extract, 1-3 parts of a lotus root extract, 1-3 parts of an abelmoschus esculentus fruit extract, and 1-3 parts of 1, 2-hexanediol. The composition with the moisturizing and anti-saccharification effects shows remarkable advantages in core performance such as moisturizing, anti-saccharification, stability and transdermal absorption, selection of technological parameters directly influences the final effect, and innovativeness of collaborative optimization of the formula and the technology is verified.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with moisturizing and anti-glycation effects and a preparation method thereof. Background Art

[0002] Cosmetic compositions are widely used in the skin care field, with primary functions including moisturizing, anti-aging, and antioxidant benefits. In recent years, anti-glycation has become a research hotspot. The accumulation of advanced glycation end products (AGEs) can lead to decreased skin elasticity and wrinkle formation. Existing technologies disclose moisturizing compositions containing Tremella fuciformis extract, but their anti-glycation effects are limited. Alternatively, solutions that use a single plant extract combined with a polyol suffer from poor ingredient stability and prone to precipitation.

[0003] In existing products, butylene glycol is often compounded with high-molecular-weight polymers as a humectant, but excessive use can lead to a sticky feeling. Literature has reported the use of 1,2-hexanediol as a preservative, but its compatibility with plant extracts has not been addressed. In actual applications, direct compounding of Tremella fuciformis extract with Dioscorea zingiberensis root extract has been found to easily cause flocculation, affecting the product's appearance. Furthermore, existing anti-glycation ingredients such as aminoguanidine, while effective, are highly irritating and unsuitable for use on sensitive skin.

[0004] Existing technologies primarily address these issues with two approaches: adding surfactants to improve dispersibility, but this reduces the permeability of the active ingredient; and employing nano-encapsulation technology, which significantly increases production costs. Adjusting the pH value to stabilize the system can also alter the skin microenvironment. Therefore, there is an urgent need to develop a novel composition that combines excellent stability, high moisturizing properties, and mild anti-glycation properties.

[0005] Therefore, it is necessary to design a composition with moisturizing and anti-glycation effects and a preparation method thereof. Summary of the Invention

[0006] In order to overcome the defects in the prior art, a composition with moisturizing and anti-glycation effects and a preparation method thereof are provided.

[0007] In order to achieve the above object, the present invention provides the following technical solutions: A composition with moisturizing and anti-glycation effects comprises the following components, measured in parts by mass: 70-85 parts of water, 8-12 parts of butylene glycol, 0.2-0.3 parts of Tremella fuciformis fruiting body extract, 1-3 parts of Dioscorea zingiberensis root extract, 1-3 parts of Lotus root extract, 1-3 parts of Ambrette cinnamomea fruit extract, and 1-3 parts of 1,2-hexanediol.

[0008] The composition further comprises 0.5-1.2 parts of lecithin-coated micelles.

[0009] The preparation of the lecithin-coated micelles comprises: A. Dissolve ceramide NPs and γ-polyglutamic acid in anhydrous ethanol at a mass ratio of 1:3-1:5; B. Inject phosphate buffer containing lecithin and stir magnetically at 800 rpm for 30 minutes; C. Lecithin-coated micelles were obtained by three cycles of high-pressure homogenization.

[0010] The Tremella fuciformis fruiting body extract is prepared by the following steps: crushing the Tremella fuciformis fruiting body and mixing it with deionized water at a mass ratio of 1:20, ultrasonically extracting it at 85° C. for 40 minutes, filtering it, and then freeze-drying it.

[0011] The ultrasonic frequency is 45 kHz, and the freeze-drying temperature is -50°C to -40°C.

[0012] The coffee sunflower fruit extract is subjected to enzymatic modification treatment: the extract is reacted with cellulase at a mass ratio of 1:0.01 at a pH of 5.0 for 2 hours.

[0013] The reaction temperature in the enzymatic modification treatment is 43-47°C.

[0014] The lotus root extract is extracted by microwave-ultrasound synergistic extraction, and the specific extraction parameters are: the mass ratio of lotus root raw material to ethanol solution is 1:15, the microwave power is 800W, intermittent radiation, working for 10s / interval of 5s; 40kHz ultrasound is applied simultaneously, and the extract is purified by macroporous resin.

[0015] A method for preparing a composition with moisturizing and anti-glycation effects comprises the following steps: premixing 0.2-0.3 parts of a Tremella fuciformis fruiting body extract, 1-3 parts of a Dioscorea japonica root extract, 1-3 parts of a Lotus root extract, 1-3 parts of a Coffea sibiricum fruit extract, and 70-85 parts of water at 60°C, and stirring at 400 rpm for 20 minutes; sequentially adding 8-12 parts of butanediol and 1-3 parts of 1,2-hexanediol; cooling to 45°C, and adding 0.5-1.2 parts of lecithin-coated micelles; adjusting the pH to 5.5-6.0 with a citric acid / sodium citrate buffer system, homogenizing, and filtering through a 0.1-μm microporous filter membrane to obtain the composition with moisturizing and anti-glycation effects.

[0016] The homogenization process is carried out in two stages: first-stage homogenization at 25 MPa for 3 cycles, and second-stage homogenization at 10 MPa for 2 cycles to eliminate microbubbles. The bubble density observed under a microscope is ≤5 / mm. 2 ; After homogenization, the system viscosity is controlled to 1500-1800cP.

[0017] Compared with the prior art, the advantages and beneficial effects of the present invention are: 1. This application achieves multiple breakthroughs in efficacy through innovative formulas and process optimization: Tremella polysaccharides and lotus root polyphenols synergistically resist glycation. The former activates the SIRT1 gene to regulate sugar metabolism, while the latter chelates free sugar molecules. Combined with Dioscorea root and enzymatically hydrolyzed coffee sunflower fruit extract, a multi-pathway system is formed to inhibit AGEs production, increasing the clearance rate by 42%-55%. Butanediol and 1,2-hexanediol form a small molecule water-locking layer, synergizing with the Tremella polysaccharide three-dimensional moisturizing film and the γ-polyglutamic acid micelle sustained-release system, maintaining skin moisture at 83% for 6 hours. , an increase of 27% compared with the traditional hyaluronic acid system; lecithin-coated micelle technology combined with a two-stage homogenization process stabilizes the particle size of the active ingredient at 50-80nm, and the viscosity is controlled at 1500-1800cP, achieving 24 months without precipitation; microwave-ultrasound synergistic extraction increases the yield of lotus root polyphenols by 2.3 times, and cellulose enzymatic hydrolysis enhances the transdermal absorption of coffee sunflower fruit to 71.4%; the entire process adopts 45kHz low-temperature ultrasound and -50℃ freeze-drying technology, and the polysaccharide activity is retained by more than 95%, meeting the organic certification standards.

[0018] 2. Three-dimensional improvement of moisturizing performance Butanediol and 1,2-hexanediol form a small-molecule polyol moisturizing network, trapping water molecules through hydroxyl groups for instant hydration (a 0.5% concentration offers superior moisturizing properties to 3% glycerin). Tremella polysaccharide, with its million-level molecular weight, forms a three-dimensional moisture-locking membrane. Combined with γ-polyglutamic acid in lecithin-encapsulated micelles, this creates a three-dimensional moisturizing system within the stratum corneum: outer film formation, mid-layer sustained release, and deep penetration. Testing showed that the combination maintained 83% of initial skin moisture six hours after application, a 27 percentage point increase compared to conventional hyaluronic acid systems.

[0019] 3. Breakthrough improvement in ingredient stability Using lecithin-coated micelle technology, hydrophobic ceramide NPs and hydrophilic γ-polyglutamic acid are assembled into stable micelles with a controlled particle size range of 50-80 nm, addressing the problem of plant extract precipitation. A two-stage homogenization process (25 MPa high-pressure crushing of aggregates and 10 MPa elimination of microbubbles) stabilizes the system viscosity at 1500-1800 cP. Microscopic observations show a micelle dispersion uniformity of 98.7%, extending the shelf life to 24 months without phase separation.

[0020] 4. Significant improvement in bioavailability During the microwave-ultrasound synergistic extraction of lotus root polyphenols, 800W pulsed microwaves triggered instantaneous cell wall disruption, while 40kHz ultrasonic cavitation promoted the dissolution of active substances, increasing quercetin yield by 2.3 times. Cellulase-directed hydrolysis of sunflower berries reduced their molecular weight from 200,000 Da to 80,000 Da, increasing transdermal absorption to 71.4%. The biomimetic membrane structure formed by the lecithin coating allowed ceramides to penetrate deep into the dermis, reducing epidermal retention by 38%.

[0021] 5. Balance between process safety and cost control Tremella fuciformis extraction utilizes 45kHz low-frequency ultrasound (below the protein denaturation threshold) coupled with freeze-drying at -50°C, resulting in over 95% polysaccharide activity retention and 62% lower energy consumption than traditional reflux methods. During the enzymatic hydrolysis and modification phase, precise temperature control (43-47°C) and a pH of 5.0 ensure peak cellulase activity for 135 minutes, resulting in a substrate conversion rate of 92.7%, shortening the processing time by one-third compared to conventional methods. The entire process is free of residual organic solvents, meeting ECOCERT organic certification standards.

[0022] 6. Multi-target synergistic enhancement of anti-glycation efficacy Tremella polysaccharides in Tremella fuciformis fruiting body extract activate the cellular autophagy pathway to clear advanced glycation end products (AGEs), while polyphenolic tannins in lotus root extract chelate free sugar molecules to block the initial stages of the glycation reaction. Japanese Dioscorea root extract and Coffea chinensis fruit extract, after enzymatic modification, contain flavonoids that regulate blood sugar by modulating the activity of sugar metabolizing enzymes, forming a complete anti-glycation pathway from prevention to clearance. Compared to single-ingredient systems, this combination increases AGE clearance by 42%-55% while avoiding the irritation of aminoguanidine ingredients, making it suitable for sensitive skin. DETAILED DESCRIPTION

[0023] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0024] In this application, the models of various raw materials are briefly described as follows: Ceramide NP: purchased from Evonik, Germany, model TEGO® Cosmo C100 (nanograde, purity ≥98%).

[0025] Lecithin: purchased from Lipoid, model Lipoid S75 (hydrogenated soybean lecithin, phosphatidylcholine content ≥ 70%).

[0026] γ-Polyglutamic acid: purchased from Bloomage Biotech, model Hyalo® PGA (molecular weight 100-150 kDa, produced by fermentation method).

[0027] 1,2-Hexanediol: purchased from BASF, model Hydrolite® 5 (cosmetic grade, purity ≥99.5%).

[0028] Butanediol: purchased from Dow Chemical, model DOWANOL™ TPnB (food grade, water content ≤0.1%).

[0029] Cellulase: purchased from Novozymes, model Celluclast® 1.5L (enzyme activity ≥ 700 EGU / g).

[0030] Macroporous resin: purchased from Sunresin, model LX-68 (pore size 30-50Å, cross-linking degree 8%).

[0031] A composition with moisturizing and anti-glycation effects comprises the following components, measured in parts by mass: 70-85 parts of water, 8-12 parts of butylene glycol, 0.2-0.3 parts of Tremella fuciformis fruiting body extract, 1-3 parts of Dioscorea zingiberensis root extract, 1-3 parts of Lotus root extract, 1-3 parts of Ambrette cinnamomea fruit extract, and 1-3 parts of 1,2-hexanediol.

[0032] The composition further comprises 0.5-1.2 parts of lecithin-coated micelles.

[0033] The preparation of the lecithin-coated micelles comprises: A. Dissolve ceramide NPs and γ-polyglutamic acid in anhydrous ethanol at a mass ratio of 1:3-1:5; B. Inject phosphate buffer containing lecithin and stir magnetically at 800 rpm for 30 minutes; C. Lecithin-coated micelles were obtained by three cycles of high-pressure homogenization.

[0034] The Tremella fuciformis fruiting body extract is prepared by the following steps: crushing the Tremella fuciformis fruiting body and mixing it with deionized water at a mass ratio of 1:20, ultrasonically extracting it at 85° C. for 40 minutes, filtering it, and then freeze-drying it.

[0035] The ultrasonic frequency is 45 kHz, and the freeze-drying temperature is -50°C to -40°C.

[0036] The coffee sunflower fruit extract is subjected to enzymatic modification treatment: the extract is reacted with cellulase at a mass ratio of 1:0.01 at a pH of 5.0 for 2 hours.

[0037] The reaction temperature in the enzymatic modification treatment is 43-47°C.

[0038] The lotus root extract is extracted by microwave-ultrasound synergistic extraction, and the specific extraction parameters are: the mass ratio of lotus root raw material to ethanol solution is 1:15, the microwave power is 800W, intermittent radiation, working for 10s / interval of 5s; 40kHz ultrasound is applied simultaneously, and the extract is purified by macroporous resin.

[0039] A method for preparing a composition with moisturizing and anti-glycation effects comprises the following steps: premixing 0.2-0.3 parts of a Tremella fuciformis fruiting body extract, 1-3 parts of a Dioscorea japonica root extract, 1-3 parts of a Lotus root extract, 1-3 parts of a Coffea sibiricum fruit extract, and 70-85 parts of water at 60°C, and stirring at 400 rpm for 20 minutes; sequentially adding 8-12 parts of butanediol and 1-3 parts of 1,2-hexanediol; cooling to 45°C, and adding 0.5-1.2 parts of lecithin-coated micelles; adjusting the pH to 5.5-6.0 with a citric acid / sodium citrate buffer system, homogenizing, and filtering through a 0.1-μm microporous filter membrane to obtain the composition with moisturizing and anti-glycation effects.

[0040] The homogenization process is carried out in two stages: first-stage homogenization at 25 MPa for 3 cycles, and second-stage homogenization at 10 MPa for 2 cycles to eliminate microbubbles. The bubble density observed under a microscope is ≤5 / mm. 2 ; After homogenization, the system viscosity is controlled to 1500-1800cP.

[0041] This application achieves three breakthroughs in the field of moisturizing and anti-glycation through innovative formula system and process optimization: First, Tremella polysaccharide and lotus root polyphenol form a synergistic anti-glycation network. The former regulates sugar metabolism by activating SIRT1 gene, while the latter chelates free sugar molecules. Combined with Japanese yam root and enzymatically modified coffee sunflower fruit extract, it achieves multi-pathway inhibition of AGEs formation (clearance rate increased by 42%-55%). Secondly, it constructs a small molecule water-locking layer of butanediol-1,2-hexanediol and a three-dimensional moisturizing film of Tremella polysaccharide. The combined γ-polyglutamic acid micelle sustained-release system can maintain the skin's moisture content at 83% within 6 hours, which is 27% higher than the traditional hyaluronic acid system. Thirdly, through lecithin-coated micelle technology and a two-stage homogenization process, the particle size of the active ingredient is controlled at 50-80nm, and the viscosity of the system is stabilized at 1500-1800cP, achieving 24 months without precipitation. At the same time, the microwave-ultrasound synergistic extraction and low-temperature enzymatic hydrolysis process increase the yield of active ingredients by 2.3 times and reduce energy consumption by 62%, achieving both efficacy and production economy.

[0042] The present application is further described below with reference to specific embodiments, comparative examples, and analytical tests:

[0043] Example 1

[0044] Formula composition: 85 parts of water, 10 parts of butylene glycol, 0.3 parts of Tremella fuciformis fruiting body extract, 2 parts of Japanese Dioscorea root extract, 1 part of Lotus root extract, 3 parts of Coffea chinensis fruit extract, 1 part of 1,2-hexanediol, and 1.2 parts of lecithin-coated micelles.

[0045] Preparation process: Tremella fuciformis fruiting body extract: The Tremella fuciformis fruiting body was crushed and mixed with deionized water at a mass ratio of 1:20. Ultrasonic extraction was performed at 85°C and 45kHz for 40 minutes. The mixture was filtered and freeze-dried at -50°C.

[0046] Neptune fruit extract: Mix the extract with cellulase in a mass ratio of 1:0.01 and react at pH 5.0 and 47°C for 2 hours.

[0047] Lotus root extract: Microwave-ultrasonic synergistic extraction was used. The lotus root raw material and ethanol solution were mixed in a mass ratio of 1:15. The microwave power was 800W (working 10 seconds / interval 5 seconds), and 40kHz ultrasound was applied simultaneously. The extract was purified by macroporous resin.

[0048] Preparation of the composition: Tremella fuciformis fruiting body extract, Japanese yam root extract, lotus root extract, and coffee sunflower fruit extract were premixed with water at 60°C and stirred at 400 rpm for 20 minutes; butanediol and 1,2-hexanediol were added in sequence; after cooling to 45°C, lecithin-coated micelles were added; the pH was adjusted to 6.0 with a citric acid / sodium citrate buffer system, and the mixture was homogenized in two stages (25 MPa for 3 cycles → 10 MPa for 2 cycles) to a final viscosity of 1800 cP, and filtered through a 0.1 μm microporous membrane.

[0049] Example 2 In this embodiment, the same points as in Example 1 are not described in detail, and the differences are as follows: Formula composition: 70 parts of water, 12 parts of butylene glycol, 0.2 parts of Tremella fuciformis fruiting body extract, 3 parts of Japanese Dioscorea root extract, 3 parts of Lotus root extract, 1 part of Coffea chinensis fruit extract, 3 parts of 1,2-hexanediol, and 0.5 parts of lecithin-coated micelles.

[0050] Process adjustment: The freeze-drying temperature of Tremella fuciformis fruiting body extract is -40°C.

[0051] The enzymatic hydrolysis reaction temperature of coffee sunflower fruit was adjusted to 43°C.

[0052] The lotus root was extracted using continuous microwave irradiation (800W continuous power).

[0053] After homogenization, the viscosity is 1500 cP and the pH is 5.5.

[0054] Example 3 In this embodiment, the same points as in Example 1 are not described in detail, and the differences are as follows: Formula composition: 78 parts of water, 8 parts of butylene glycol, 0.25 parts of Tremella fuciformis fruiting body extract, 1 part of Japanese Dioscorea root extract, 2 parts of Lotus root extract, 2 parts of Coffee Sunflower fruit extract, 2 parts of 1,2-hexanediol, and 0.8 parts of lecithin-coated micelles.

[0055] Process adjustment: The ultrasonic extraction time of Tremella fuciformis fruiting body was shortened to 30 minutes.

[0056] The pH of coffee sunflower fruit enzymatic hydrolysis was adjusted to 5.5.

[0057] After homogenization, the viscosity is 1650 cP and the pH is 5.8.

[0058] Comparative Example 1

[0059] In this comparative example, the same points as in Example 1 are not repeated here, and the differences are as follows: No lecithin-coated micelles added.

[0060] Comparative Example 2

[0061] In this comparative example, the same points as in Example 1 are not repeated here, and the differences are as follows: Coffea arvense fruit extract is not enzymatically processed.

[0062] Comparative Example 3

[0063] In this comparative example, the same points as in Example 1 are not repeated here, and the differences are as follows: Lotus root extraction was carried out using the traditional thermal reflux method (without microwave-ultrasound synergy).

[0064] Comparative Example 4

[0065] In this comparative example, the same points as in Example 1 are not repeated here, and the differences are as follows: Hyaluronic acid is used instead of Tremella fuciformis fruiting body extract.

[0066] Comparative Example 5

[0067] In this comparative example, the same points as in Example 1 are not repeated here, and the differences are as follows: The homogenization process was only single-stage (25 MPa, without secondary homogenization).

[0068] Test methods and results

[0069] The products of the examples and comparative examples were tested according to the following test indicators. The test results are shown in Table 1.

[0070] 1. Moisturizing performance: The skin's moisture content was measured using a Corneometer® and the moisture retention rate was calculated 6 hours after application.

[0071] 2. Anti-glycation effect: The AGEs clearance rate was determined using the in vitro BSA-fructose model.

[0072] 3. Stability: The micelle particle size was determined by dynamic light scattering method, and the viscosity change after 3 months of storage was measured by viscometer.

[0073] 4. Transdermal absorption rate: The transdermal absorption rate of the coffee amomum villosum fruit extract was determined by the Franz diffusion cell method.

[0074] Table 1 Performance test results of the compositions under different conditions

[0075] As can be seen from Table 1, Moisturizing properties

[0076] The moisturizing properties of Examples 1-3 (80.5%-83.2%) were significantly higher than those of all comparative examples, with Comparative Example 4 (hyaluronic acid system) achieving only 56.1%, demonstrating the synergistic effect of the Tremella fuciformis polysaccharide three-dimensional moisture-locking membrane and the small-molecule polyol. The addition of lecithin-coated micelles (Example 1 vs. Comparative Example 1) increased the moisturizing property by 14.9%, demonstrating the critical role of the γ-polyglutamic acid sustained-release system in long-lasting moisturization.

[0077] Anti-glycation effect

[0078] The AGEs removal rate in Example 1 reached 54.8%, 30.1% higher than that in Comparative Example 3 (traditional extraction method), demonstrating that microwave-ultrasound synergistic extraction significantly increased the yield of lotus root polyphenols. The removal rate in Comparative Example 2 (unenzymatically digested ambrette fruit) was only 28.9%, demonstrating that enzymatic hydrolysis of cellulose effectively reduces molecular weight and enhances the activity of flavonoids.

[0079] stability

[0080] The micelle size of Example 1 was 52 nm, and the viscosity variation was ±2.1%, which was superior to the 120 nm and ±8.9% variation in Comparative Example 5 (single-stage homogenization). This demonstrates the effectiveness of the two-stage homogenization process in micelle dispersion and bubble elimination. The lack of lecithin coating in Comparative Example 1 resulted in aggregation and precipitation of the components, demonstrating the importance of a micelle structure for stability.

[0081] Transdermal absorption rate

[0082] The transdermal absorption rate of Example 1 reached 71.4%, a 27.8% increase over Comparative Example 2 (non-enzymatically hydrolyzed), demonstrating that enzymatic hydrolysis can reduce the molecular weight of the ambrette fruit extract and enhance transdermal absorption. Comparative Example 3 (traditional thermal reflux method) achieved a transdermal absorption rate of only 39.1%, further demonstrating the enhanced dissolution of the active ingredient through microwave-ultrasound synergistic extraction.

[0083] Process optimization and verification

[0084] The Tremella fuciformis extract in Example 2 was freeze-dried at -40°C. Although its moisture retention was slightly lower than that in Example 1, it still retained over 95% of its polysaccharide activity, meeting the design goals of the low-temperature process. The single-stage homogenization in Comparative Example 5 resulted in an increase in micelle size and significant viscosity fluctuations, highlighting the necessity of secondary homogenization (10 MPa to eliminate microbubbles) for product stability.

[0085] The technical solution of the present invention demonstrates significant advantages in core performance aspects such as moisturizing, anti-glycation, stability and transdermal absorption, and the selection of process parameters (such as extraction temperature, enzymatic hydrolysis pH, and homogenization pressure) directly affects the final effect, verifying the innovativeness of the coordinated optimization of formula and process.

[0086] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A composition with moisturizing and anti-glycation effects, characterized in that: The composition includes the following components in parts by mass: 70-85 parts of water, 8-12 parts of butylene glycol, 0.2-0.3 parts of Tremella fuciformis fruiting body extract, 1-3 parts of Dioscorea zingiberensis root extract, 1-3 parts of Lotus root extract, 1-3 parts of Ambrette coffee fruit extract, and 1-3 parts of 1,2-hexanediol.

2. The composition having moisturizing and anti-glycation effects according to claim 1, characterized in that: The composition further comprises 0.5-1.2 parts of lecithin-coated micelles.

3. The composition having moisturizing and anti-glycation effects according to claim 2, characterized in that: The preparation of the lecithin-coated micelles comprises: A. Dissolve ceramide NPs and γ-polyglutamic acid in anhydrous ethanol at a mass ratio of 1:3-1:5; B. Inject phosphate buffer containing lecithin and stir magnetically at 800 rpm for 30 minutes; C. Lecithin-coated micelles were obtained by three cycles of high-pressure homogenization.

4. The composition having moisturizing and anti-glycation effects according to claim 1, characterized in that: The Tremella fuciformis fruiting body extract is prepared by the following steps: crushing the Tremella fuciformis fruiting body and mixing it with deionized water at a mass ratio of 1:20, ultrasonically extracting it at 85° C. for 40 minutes, filtering it, and then freeze-drying it.

5. The composition having moisturizing and anti-glycation effects according to claim 4, characterized in that: The ultrasonic frequency is 45 kHz, and the freeze-drying temperature is -50°C to -40°C.

6. The composition with moisturizing and anti-glycation effects according to claim 1, characterized in that: The coffee sunflower fruit extract is subjected to enzymatic modification treatment: the extract is reacted with cellulase at a mass ratio of 1:0.01 at a pH of 5.0 for 2 hours.

7. The composition with moisturizing and anti-glycation effects according to claim 6, characterized in that: The reaction temperature in the enzymatic modification treatment is 43-47°C.

8. The composition with moisturizing and anti-glycation effects according to claim 1, characterized in that: The lotus root extract is extracted by microwave-ultrasound synergistic extraction, and the specific extraction parameters are: the mass ratio of lotus root raw material to ethanol solution is 1:15, the microwave power is 800W, intermittent radiation, working for 10s / interval of 5s; 40kHz ultrasound is applied simultaneously, and the extract is purified by macroporous resin.

9. A method for preparing a composition having moisturizing and anti-glycation effects according to any one of claims 1 to 8, characterized in that: 0.2-0.3 parts of Tremella fuciformis fruiting body extract, 1-3 parts of Dioscorea japonica root extract, 1-3 parts of Lotus root extract, 1-3 parts of Amomum villosum fruit extract and 70-85 parts of water are premixed at 60°C and stirred at 400 rpm for 20 minutes; 8-12 parts of butanediol and 1-3 parts of 1,2-hexanediol are added in sequence; after cooling to 45°C, 0.5-1.2 parts of lecithin-coated micelles are added; the pH is adjusted to 5.5-6.0 with a citric acid / sodium citrate buffer system, and the mixture is homogenized and filtered through a 0.1 μm microporous filter membrane to obtain a composition with moisturizing and anti-glycation effects.

10. The method for preparing a composition with moisturizing and anti-glycation effects according to claim 9, characterized in that: The homogenization process is carried out in two stages: first-stage homogenization at 25 MPa for 3 cycles, and second-stage homogenization at 10 MPa for 2 cycles to eliminate microbubbles. The bubble density observed under a microscope is ≤5 / mm. 2 ; After homogenization, the system viscosity is controlled to 1500-1800cP.

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