Marker for distinguishing colorectal cancer and colorectal adenoma and application thereof

Abstract

The invention belongs to the technical field of diagnosis, and particularly relates to a marker for distinguishing colorectal cancer and colorectal adenoma and application of the marker. The invention discloses one or more of 75 markers as the marker for distinguishing the colorectal cancer and the colorectal adenoma for the first time, and the colorectal cancer and the colorectal adenoma can be distinguished by detecting the content, the expression quantity and / or the activity of the marker.

Description

Technical Field

[0001] The present invention belongs to the field of diagnostic technology, and specifically relates to markers for distinguishing colorectal cancer from colorectal adenoma and applications thereof. Background Art

[0002] Colorectal cancer (carcinoma of the colon and rectum) is a common malignant tumor of the gastrointestinal tract. Its incidence and mortality are second only to gastric cancer, esophageal cancer, and primary liver cancer among digestive system malignancies. In recent years, the incidence of colorectal cancer has been increasing year by year. While its etiology is not fully understood, factors such as the environment, diet, and lifestyle (alcohol consumption and smoking) may contribute to the risk. Furthermore, familial polyps, ulcerative colitis, and a family history of tumors are also high-risk factors.

[0003] Colorectal cancer develops through a progression from normal to adenoma to tumor. Some patients can remain in the colorectal adenoma stage for 10 to 15 years before developing cancer. This adenoma stage provides a crucial window for early diagnosis and intervention of colorectal cancer. Research has largely focused on screening and identifying molecular markers that can distinguish between normal individuals and cancer patients. Currently, molecular markers that can monitor the progression of colorectal cancer, specifically the adenoma-to-tumor transition, are scarce. Therefore, identifying molecular markers that can differentiate between colorectal adenomas and colorectal cancer is crucial for early diagnosis and intervention of colorectal cancer. Summary of the Invention

[0004] The purpose of the first aspect of the present invention is to provide the use of a substance for detecting a marker in the preparation of a product for distinguishing colorectal cancer from colorectal adenoma.

[0005] The second aspect of the present invention aims to provide a marker combination for distinguishing colorectal cancer from colorectal adenoma.

[0006] The third aspect of the present invention aims to provide a product for distinguishing colorectal cancer from colorectal adenoma.

[0007] The fourth aspect of the present invention aims to provide a method for constructing a model for distinguishing colorectal cancer from colorectal adenoma.

[0008] The fifth aspect of the present invention aims to provide a device or system for distinguishing colorectal cancer from colorectal adenoma.

[0009] The sixth aspect of the present invention aims to provide a computer device.

[0010] The seventh aspect of the present invention aims to provide a computer storable medium.

[0011] The purpose of the eighth aspect of the present invention is to provide a method for distinguishing colorectal cancer from colorectal adenoma.

[0012] In order to achieve the above object, the technical solution adopted by the present invention is:

[0013] The first aspect of the present invention provides the use of a substance for detecting a marker in preparing a product:

[0014] The product is used to differentiate colorectal cancer from colorectal adenoma;

[0015] The marker is A, and A includes at least one of B, that is, it can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87 6, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, or 75;

[0016] The B group includes: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAM DC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPI NT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, UPB1 (i.e., 75 proteins in Table 1).

[0017] Preferably, the A comprises any 1, 2, 3, 4, 5, 6, 7, or 8 of the Bs.

[0018] Preferably, the A comprises a single marker, and the single marker is any one of the B, such as: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, EN PP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITG A11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE 8. MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRT N3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, or UPB1.

[0019] Preferably, the single marker is: CLEC3B, IGFBP2, FAP, CEACAM5, AREG, PLXDC2, MEGF9, DPP4, CKB, TNC, CFP, LRG1, ITIH3, FGA, CD34, SERPINA1, HEG1, MAMDC4, MZB1, MCAM, ADA M12, PEPD, AGR3, PTX3, SSC4D, GDF15, ADAMTSL4, ITGA11, NAGPA, CD58, SSBP1, ITGAV, CPM, RTN4R, APOA4, PTH, C1QTNF1, DCXR, UPB1, TINAGL1, CNTN4, IL17RA, MF GE8, CA14, RPGR, ACY1, PKD1, PEAR1, PDIA4, SLAMF8, PCDH7, NCS1, PPY, KRT19, ENP P6, GNAS, LILRA4, RAB37, HPGDS, ESM1, IL1R2, COMP, KHK, or CDH23 (i.e., 64 proteins in Table 2); among them, the content, expression and / or activity of IGFBP2, CEACAM5, AREG, CKB, TNC, LRG1, ITIH3, FGA, SERPINA1, MZB1, ADAM12, PTX3, GDF15, ADAMTSL4, SSBP1, C1QTNF1, TINAGL1, PDIA4, SLAMF8, PPY, KRT19, RAB37, and ESM1 in the subjects with colorectal cancer are increased compared with the levels in the subjects with colorectal adenoma, and ... The content, expression and / or activity of CLEC3B, FAP, PLXDC2, MEGF9, DPP4, CFP, CD34, HEG1, MAMDC4, MCAM, PEPD, AGR3, SSC4D, ITGA11, NAGPA, CD58, ITGAV, CPM, RTN4R, APOA4, PTH, DCXR, UPB1, CNTN4, IL17RA, MFGE8, CA14, RPGR, ACY1, PKD1, PEAR1, PCDH7, NCS1, ENPP6, GNAS, LILRA4, HPGDS, IL1R2, COMP, KHK, and CDH23 in the test subject are decreased compared with the test subject having colorectal adenoma.

[0020] Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, IGFBP2, ADAMTSL4, PEPD, MAMDC4, FGA, CEACAM5, MEGF9, LRG1, ITIH3, TNC, ITGAV, CD34, CKB, SL AMF8, DPP4, HPGDS, KHK, MCAM, AGR3, DCXR, FAP, PKD1, IL1R2, PTX3, RAB37, PLXD C2, MZB1, CPM, or CFP (i.e., 34 proteins in Table 3).

[0021] Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, or IGFBP2.

[0022] Preferably, the A comprises a combination of 2 markers, and the combination of 2 markers is any two of the Bs.

[0023] Preferably, the 2markers combination is: SERPINA1 and IL17RA, AREG and HEG1, CLEC3B and SERPINA1, AREG and PKD1, AREG and PEPD, PDIA4 and PEPD, PRDX1 and SERPINA1, DCXR and SERPINA1, AREG and CD55, IL1RAP and SERPINA1, ADAM12 and FAP, PLXDC2 and SERPINA1, PEPD and SERPINA1, AREG and CD34, PDIA4 and PKD1, AREG and NCS1, ALCAM and PDIA4, or AREG and MCAM (i.e., the 2markers combination in Table 4).

[0024] Preferably, the A comprises a combination of 3 markers, and the combination of 3 markers is any 3 of the B.

[0025] Preferably, the 3 markers combination is any 3 of C, and the C is: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF9, NCS1, PDIA4, PEPD, PKD1, PLXDC2, PRDX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC.

[0026] Preferably, the three markers combination is: AREG, PKD1 and DCXR, CEACAM5, FGA and HEG1, AREG, ADAM12 and NCS1, PDIA4, CEACAM5 and HEG1, SERPINA1, IL17RA and PLXDC2, SERPINA1, TBCB and PLXDC2, AREG, FGA and HEG1, PDIA4, PKD1 and PEPD, AREG, CEACAM5 and HEG1, AREG, AD AMTSL4 and PKD1, AREG, ADAM12 and PKD1, PDIA4, PEPD and IL17RA, PDIA4, PEPD and HEG1, TNC, MAMDC4 and MCAM, AREG, TNC and PKD1, SERPINA1, CEACAM5 and HEG1, SERPINA1, CL EC3B and IL17RA, SERPINA1, PDIA4 and PLXDC2, PDIA4, FGA and HEG1, ADAM12, AGR3 and IL1RA P, SERPINA1, ADAM12 and PRDX1, PDIA4, PEPD and FAP, AREG, CD34 and DCXR, CEACAM5, AD AMTSL4 and HEG1, ADAM12, CEACAM5 and HEG1, SERPINA1, ASPN and PLXDC2, CEACAM5, FGA and MEGF9, PDIA4, TBCB and FAP, SERPINA1, AREG and PLXDC2, PDIA4, PKD1 and DCXR, SERPIN A1, IL1RAP and PLXDC2, TNC, MAMDC4 and PLXDC2, FGA, MAMDC4 and HEG1, SERPINA1, PDIA 4 and IL17RA, PDIA4, CEACAM5 and PEPD, PDIA4, CEACAM5 and MEGF9, CEACAM5, SLAMF8 and MEGF9, SERPINA1, CLEC3B and IL1RAP, AREG, SLAMF8 and DCXR, PDIA4, ASPN and HEG1, AREG, FGA and PKD1, FGA, SLAMF8 and HEG1, AREG, MCAM and DCXR, PDIA4, ITIH3 and PKD1, SERPIN A1, CEACAM5 and MEGF9, SERPINA1, FGA and HEG1, ADAM12, DCXR and IL1RAP, SERPINA1, ADAM12 and NCS1, PDIA4, MCAM and DCXR, AREG, HEG1 and DCXR, SERPINA1, AREG and IL17RA, SERPINA1, SLAMF8 and DCXR, PDIA4, ASPN and PEPD,SERPINA1, CLEC3B and PRDX1, AREG, TB CB and HEG1, TNC, PKD1 and MAMDC4, PDIA4, PKD1 and MAMDC4, PDIA4, IL17RA and ALCAM, PDIA4, TNC and MCAM, AREG, PDIA4 and PKD1, PDIA4, TNC and IL17RA, AREG, ADAMTSL4 and HE G1, SERPINA1, SLAMF8 and PEPD, ADAM12, PDIA4 and PEPD, ADAM12, ITIH3 and PKD1, AREG, HEG1 and MCAM, SERPINA1, TNC and PLXDC2, CEACAM5, HEG1 and PRDX1, PKD1, SLAMF8 and DCXR, ADAM12, FGA and HEG1, PDIA4, ITIH3 and MCAM, PDIA4, FGA and PKD1, SERPINA1, HEG1 and PLXDC2, AREG, PEPD and HEG1, ADAM12, FGA and CD34, ADAM12, FAP and PRDX1, FGA, TB CB and HEG1, CEACAM5, TNC and MEGF9, SERPINA1, PDIA4 and PKD1, AREG, ASPN and PKD1, AD AM12, FGA and PEPD, SERPINA1, FAP and PRDX1, PDIA4, FGA and PEPD, PDIA4, TNC and PKD1, AREG, PDIA4 and PEPD, SERPINA1, ADAMTSL4 and IL17RA, ADAM12, CD55 and FAP, AREG, ASPN and AGR3, AREG, ASPN and IL17RA, SERPINA1, CEACAM5 and IL17RA, AREG, MEGF9 and NCS1, SERPINA1, ADAM12 and PKD1, CEACAM5, TNC and HEG1, PDIA4, MAMDC4 and PLXDC2, PDIA4, IGFBP2 and PKD1, AREG, TBCB and PKD1, SERPINA1, ADAM12 and IL17RA, ADAM12, CEACAM5 and NCS1, SERPINA1, ADAM12 and CLEC3B, AREG, TNC and MCAM, FGA, IGFBP2 and PKD1, AREG, PKD1 and PEPD, ADAM12, TBCB and FAP, AREG, ITIH3 and PKD1, PDIA4, CEACAM5 and IL17RA, AREG, PKD1 and CD55, TNC, IGFBP2 and MCAM, CEACAM5, SLAMF8 and HEG1, AREG, TBCB and CD55,AREG, FAP and IL1RAP, PDIA4, ITIH3 and CD34, AREG, FGA and NCS1, ADAM12, FGA and NC S1, SERPINA1, ADAM12 and PEPD, PDIA4, HEG1 and PLXDC2, SERPINA1, CEACAM5 and PRDX1, SERPINA1, TNC and IL17RA, AREG, ASPN and HEG1, AREG, PDIA4 and IL17RA, PDIA4, PEPD and MC AM, PDIA4, IGFBP2 and CD55, ADAM12, CEACAM5 and MEGF9, AREG, CEACAM5 and PKD1, AREG, PDIA4 and CD34, AREG, ADAM12 and CD55, AREG, ADAM12 and DCXR, PDIA4, MEGF9 and PEP D, SERPINA1, PKD1 and DCXR, SERPINA1, CLEC3B and ASPN, AREG, ASPN and MCAM, ADAM12, ITIH3 and CD34, SERPINA1, CLEC3B and PLXDC2, AREG, TNC and NCS1, SERPINA1, CEACAM5 and PKD1, SERPINA1, SLAMF8 and HEG1, AREG, MAMDC4 and PLXDC2, ADAM12, PEPD and FAP, SERP INA1, DCXR and PLXDC2, AREG, ADAMTSL4 and NCS1, AREG, ADAM12 and IL17RA, SERPINA1, AREG and CD55, PDIA4, IGFBP2 and PEPD, SERPINA1, PDIA4 and HEG1, SERPINA1, IL17RA and DCXR, PDIA4, CEACAM5 and PKD1, SERPINA1, SLAMF8 and PLXDC2, AREG, NCS1 and MCAM, SERP INA1, PKD1 and PLXDC2, ADAM12, ASPN and AGR3, SLAMF8, MCAM and DCXR, PDIA4, PEPD and CD34, CEACAM5, IGFBP2 and HEG1, AREG, FGA and MEGF9, PDIA4, CEACAM5 and DCXR, AREG, TNC and HEG1, SERPINA1, TNC and PKD1, SERPINA1, CD34 and DCXR, PDIA4, TBCB and HEG1, SERPIN A1, FGA and CLEC3B, ADAM12, CEACAM5 and IL1RAP, SERPINA1, MAMDC4 and PLXDC2, CEACAM M5, ITIH3 and HEG1, CEACAM5, TNC and FAP,SERPINA1, CEACAM5 and DCXR, SERPINA1, AREG and DCXR, PDIA4, ASPN and MCAM, ADAM12, ITIH3 and CLEC3B, AREG, MCAM and IL1RAP, ADAM12, CEACAM5 and PRDX1, AREG, ADAMTSL4 and CD55, CEACAM5, TNC and MCAM, AREG, PK D1 and PRTN3, AREG, MAMDC4 and HEG1, SERPINA1, AREG and CLEC3B, AREG, PDIA4 and HEG1, SERPINA1, PRDX1 and PLXDC2, SERPINA1, MEGF9 and IL17RA, SERPINA1, ADAM12 and PLXDC2, AREG, PEPD and NCS1, PDIA4, TBCB and PEPD, ADAM12, TBCB and NCS1, SERPINA1, PDIA4 and MEGF9, SERPINA1, CEACAM5 and IL1RAP, TNC, IGFBP2 and PKD1, PDIA4, CD55 and ALCAM, SERPI NA1, AREG and PKD1, AREG, FGA and DCXR, SERPINA1, FAP and PLXDC2, PDIA4, IGFBP2 and ALCAM, SERPINA1, CEACAM5 and PEPD, AREG, AGR3 and IL1RAP, SERPINA1, AGR3 and IL1RAP, ADAM12, FGA and PKD1, AREG, CLEC3B and PKD1, ADAM12, TBCB and PKD1, CEACAM5, TBCB and HEG1, AREG, PDIA4 and DCXR, AREG, HEG1 and IL1RAP, SERPINA1, ADAM12 and IL1RAP, PDIA4, TNC and PLXDC2, PDIA4, SLAMF8 and PEPD, AREG, TNC and PLXDC2, AREG, FGA and MCAM, PDI A4, PKD1 and ALCAM, PDIA4, PKD1 and PRDX1, ADAM12, FAP and IL1RAP, PDIA4, TBCB and MCA M, SERPINA1, CD34 and IL1RAP, ADAM12, PDIA4 and DCXR, AREG, PKD1 and HEG1, SERPINA1, PEPD and PLXDC2, SERPINA1, HEG1 and PRDX1, PDIA4, DCXR and ALCAM, SERPINA1, ADAM12 and DCXR, SERPINA1, CLEC3B and SLAMF8, AREG, PKD1 and MAMDC4, ADAM12, ASPN and FAP,FGA, MAMDC4 and CD34, AREG, ADAMTSL4 and MCAM, AREG, MAMDC4 and CD55, PDIA4, ADAMTSL4 and PKD1, ADAM12, MAMDC4 and CD34, AREG, PKD1 and ALCAM, ADAMTSL4, SLAMF8 and PEPD, PDIA4, TBCB and PKD1, SERPINA1, IL17RA and CD55, SERPINA1, DCXR and IL1RAP, PDIA4, TBCB and CD34, TNC, ASPN and MCAM, SERPINA1, PKD1 and IL17RA, PDIA4, ITIH3 and PEPD, SER PINA1, CEACAM5 and PLXDC2, ADAM12, ASPN and HEG1, PDIA4, MAMDC4 and MCAM, SERPINA1, ADAM12 and CD34, PDIA4, IGFBP2 and MCAM, AREG, TBCB and FAP, ADAM12, IL1RAP and ALCAM, CEACAM5, TNC and IL17RA, SERPINA1, TBCB and PRDX1, AREG, ADAM12 and ALCAM, ADAM12, TBCB and IL1RAP, SERPINA1, CLEC3B and CD55, ADAM12, FGA and MAMDC4, PDIA4, TNC and ME GF9, SERPINA1, ADAMTSL4 and HEG1, AREG, PDIA4 and NCS1, SERPINA1, ADAMTSL4 and PKD1, SERPINA1, PDIA4 and PRDX1, AREG, PDIA4 and CD55, SERPINA1, CEACAM5 and CD34, PDIA4, IL 1RAP and ALCAM, SERPINA1, IL17RA and PRDX1, AREG, MAMDC4 and CD34, ADAM12, ITIH3 and NCS1, CEACAM5, FGA and PEPD, AREG, TNC and FAP, SERPINA1, FGA and IL17RA, AREG, DCXR and IL1RAP, PDIA4, PKD1 and IL17RA, PDIA4, TNC and FAP, FGA, IGFBP2 and HEG1, AREG, IL1RA P and PLXDC2, SERPINA1, CLEC3B and TBCB, ADAM12, PDIA4 and PKD1, AREG, ADAM12 and HEG1, PDIA4, PLXDC2 and ALCAM, ADAM12, PDIA4 and ALCAM, PDIA4, FAP and PRDX1,or SERPINA1, PKD1 and SLAMF8 (i.e., the 3 markers combination in Table 5).

[0027] Preferably, the A comprises a combination of 4 markers, and the combination of 4 markers is any 4 of the B.

[0028] Preferably, the four markers are combined into any four of the Cs.

[0029] Preferably, the 4 markers combination is: CEACAM5, FGA, PEPD and HEG1, AREG, CEACAM5, FGA and HEG1, ADAM12, CEACAM5, FGA and HEG1, PDIA4, CEACAM5, PEPD, HEG1, CEACAM5, FGA, HEG1 and PRDX1, AREG, PDIA4, DCXR and ALCAM, SERPINA1, CEACAM5, FGA and HEG1, AREG, FGA, HEG1 and IL1RAP, AREG, FGA, PEPD and HEG1, ADAM12, PDIA4, DCXR and ALCAM, PDIA 4, PKD1, DCXR and IL1RAP, SERPINA1, ADAM12, FAP and PRDX1, PDIA4, TNC, PEPD and FAP, SERPINA1, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, PEPD and DCXR, AREG, PDIA4, PKD1 and DC XR, PDIA4, CEACAM5, PKD1 and DCXR, PDIA4, PEPD, FAP and DCXR, SERPINA1, AREG, IL1RAP and PLXDC2, PDIA4, TBCB, PEPD and FAP, AREG, PDIA4, CEACAM5 and HEG1, AREG, ADAM 12, FAP and HEG1, SERPINA1, CEACAM5, IL1RAP and PLXDC2, PDIA4, FGA, PKD1 and DCXR, PD IA4, CEACAM5, DCXR and ALCAM, ADAM12, FGA, MAMDC4 and HEG1, PDIA4, FGA, IGFBP2 and PKD1, ADAM12, LRG1, FAP and PRDX1, CEACAM5, TNC, FGA and HEG1, ADAM12, FGA, AGR3 and IL1RAP, SERPINA1, MAMDC4, IL1RAP and PLXDC2, PDIA4, TNC, MCAM and DCXR, SERPINA 1. ADAM12, IL1RAP and PLXDC2, ADAM12, CEACAM5, FAP and PRDX1, AREG, ADAM12, PKD1 and DCXR, AREG, PKD1, SLAMF8 and DCXR, TNC, AGR3, MAMDC4 and IL1RAP, ADAM12, TBCB, FAP and PRDX1, PDIA4, CLEC3B, PKD1 and DCXR, PDIA4, FGA, PEPD and HEG1, PDIA4, PEPD, HEG1 and FAP, ADAM12, FGA, FAP and PRDX1,ADAM12, PDIA4, PKD1 and DCXR, PDIA4, SLAMF8, MCAM and DCXR, PDIA4, DCXR, IL1RAP and ALCAM, ADAM12, PEPD, FAP and PRDX1, SERPINA1, AREG, FGA and HEG1, PDIA4, TNC, IGFBP2 and MCAM, SERPINA1, AREG, PKD1 and DCXR, ARE G, TNC, MAMDC4 and NCS1, ADAM12, FAP, PRDX1 and DCXR, AREG, ADAM12, TNC and NCS1, PDIA4, IGFBP2, PKD1 and DCXR, PDIA4, IL17RA, DCXR and ALCAM, ADAM12, CLEC3B, AGR3 and IL1RAP, CEACAM5, AGR3, SLAMF8 and HEG1, SERPINA1, TNC, DCXR and PLXDC2, FGA, AG R3, SLAMF8 and HEG1, PDIA4, CEACAM5, MEGF9 and PEPD, PDIA4, TNC, MAMDC4 and CD55, CEACAM5, SLAMF8, PEPD and HEG1, SERPINA1, SLAMF8, DCXR and PLXDC2, SERPINA1, PEPD, IL1RAP and PLXDC2, SERPINA1, CEACAM5, CLEC3B and PRDX1, PDIA4, TNC, ITIH3 and PKD1, ADAM12, FGA, SLAMF8 and NCS1, TNC, CLEC3B, AGR3 and IL1RAP, PDIA4, TBCB, PKD1 and DCX R, PDIA4, FAP, DCXR and ALCAM, CEACAM5, AGR3, HEG1 and PRDX1, SERPINA1, PDIA4, PK D1 and DCXR, ADAM12, TNC, AGR3 and IL1RAP, PDIA4, PKD1, PRTN3 and PEPD, ADAM12, PDIA 4, CD55 and FAP, ADAM12, CEACAM5, DCXR and IL1RAP, SERPINA1, MEGF9, PRTN3 and IL1RAP, AREG, ADAM12, HEG1 and IL1RAP, AREG, MAMDC4, IL1RAP and PLXDC2, CEACAM5, ADAMTS L4, SLAMF8 and HEG1, ADAM12, AGR3, MAMDC4 and IL1RAP, FGA, CLEC3B, MAMDC4 and HEG1, PDIA4, ITIH3, PEPD and FAP, AREG, ADAM12, IL1RAP and PLXDC2,CEACAM5, ADAMTSL4, HE G1 and PRDX1, FGA, TBCB, MAMDC4 and HEG1, ADAM12, SLAMF8, DCXR and IL1RAP, SERPINA1, PDIA4, CEACAM5 and HEG1, AREG, TBCB, PKD1 and DCXR, AREG, CEACAM5, HEG1 and IL1RAP, PDIA4, ITIH3, PKD1 and PEPD, SERPINA1, TBCB, SLAMF8 and PLXDC2, AREG, TNC, PKD1 and MAMDC4, SERPINA1, PDIA4, MAMDC4 and PLXDC2, ADAM12, DCXR, IL1RAP and ALCAM, FGA, SLAMF8, PEPD and HEG1, PDIA4, IGFBP2, DCXR and ALCAM, SERPINA1, SLAMF8, PEPD and DCX R, PDIA4, ADAMTSL4, PKD1 and DCXR, ADAM12, TNC, FAP and PRDX1, SERPINA1, CLEC3B, IL1RAP and PLXDC2, PDIA4, PRTN3, PEPD and FAP, CEACAM5, SLAMF8, HEG1 and DCXR, PDIA4, MCAM, DCXR and ALCAM, SERPINA1, CEACAM5, HEG1 and IL1RAP, SERPINA1, HEG1, IL1RAP and PLXDC2, AREG, PKD1, DCXR and IL1RAP, AREG, ADAM12, PDIA4 and CD55, ADAM12, MAM DC4, FAP and PRDX1, PDIA4, PEPD, DCXR and IL1RAP, PDIA4, IGFBP2, CD55 and MCAM, CEACAM M5, FGA, TBCB and HEG1, CEACAM5, FGA, AGR3 and HEG1, CEACAM5, FGA, SLAMF8 and HEG1, PDIA4, CEACAM5, FGA and HEG1, CEACAM5, FGA, HEG1 and IL1RAP, CEACAM5, FGA, ADAMT SL4 and HEG1, AREG, FGA, AGR3 and HEG1, PDIA4, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, MAMDC4 and DCXR, AREG, FGA, PKD1 and HEG1, AREG, FGA, MAMDC4 and HEG1, AREG, FGA, TBCB and HEG1, CEACAM5, FGA, HEG1 and DCXR, CEACAM5, FGA, MAMDC4 and HEG1, CEACA M5, FGA, HEG1 and PLXDC2,CEACAM5, FGA, HEG1 and NCS1, CEACAM5, FGA, ASPN and HEG1, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, CEACAM5, IL17RA and DCXR, CEACAM5, FGA, PR TN3 and HEG1, CEACAM5, FGA, IGFBP2 and HEG1, CEACAM5, TNC, AGR3 and HEG1, CEACAM5, FGA, HEG1 and CD34, PDIA4, TNC, PKD1 and DCXR, CEACAM5, FGA, CLEC3B and HEG1, PDIA4, PKD1, IL17RA and DCXR, CEACAM5, FGA, MEGF9 and HEG1, CEACAM5, FGA, ITIH3 and HEG1, CEACAM5, FGA, LRG1 and HEG1, AREG, FGA, HEG1 and MCAM, ADAM12, CEACAM5, HEG1 and PRDX1, PDIA4, CEACAM5, HEG1 and CD55, AREG, FGA, ASPN and HEG1, AREG, ADAM12, PKD 1 and IL1RAP, AREG, FGA, MEGF9 and HEG1, AREG, ADAM12, PKD1 and NCS1, CEACAM5, FGA, HEG1 and MCAM, PDIA4, SLAMF8, IL17RA and DCXR, PDIA4, PEPD, HEG1 and ALCAM, ADAM12, PDIA4, PEPD and DCXR, AREG, FGA, HEG1 and PLXDC2, PDIA4, TNC, TBCB and FAP, SERPINA1, ADAM12, NCS1 and PLXDC2, ADAM12, CEACAM5, FGA and NCS1, AREG, FGA, HEG1 and ALCAM, AREG, PDIA4, PKD1 and HEG1. IA4, PEPD and DCXR, AREG, PDIA4, FGA and HEG1, PDIA4, TNC, PKD1 and MAMDC4, PDIA4, CEACAM5, TNC and HEG1, AREG, ADAM12, FGA and PKD1, SERPINA1, MAMDC4, SLAMF8 and PLXDC2, AREG, ADAM12, ITIH3 and NCS1, AREG, FGA, HEG1 and NCS1, PDIA4, CEACAM5, AGR3 and HEG1, AREG, FGA, HEG1 and DCXR, SERPINA1, AREG, DCXR and PLXDC2, AREG, FGA, PKD1 and DCXR, AREG, FGA, ADAMTSL4 and HEG1,SERP INA1, SLAMF8, HEG1 and PLXDC2, PDIA4, FGA, PEPD and FAP, PDIA4, CEACAM5, PEPD and NCS 1, PDIA4, CEACAM5, IL17RA and CD55, ADAM12, PDIA4, DCXR and IL1RAP, AREG, ADAM12, DCXR and IL1RAP, PDIA4, PKD1, DCXR and ALCAM, ADAM12, TNC, MAMDC4 and IL1RAP, AREG, ADAM12, FGA and NCS1, AREG, FGA, PKD1 and IL1RAP, AREG, PDIA4, MCAM and DCXR, AREG, CEACAM5, AGR3 and HEG1, CEACAM5, TNC, SLAMF8 and HEG1, SERPINA1, TNC, IL1RAP and PL XDC2, PDIA4, TNC, PKD1 and PEPD, PDIA4, CEACAM5, MCAM and DCXR, SERPINA1, SLAMF8, IL1RAP and PLXDC2, SERPINA1, AREG, HEG1 and PLXDC2, CEACAM5, FGA, HEG1 and ALCAM, AREG, FGA, HEG1 and PRDX1, PDIA4, FGA, IL17RA and DCXR, PDIA4, TNC, MAMDC4 and FAP, PDIA4, CEACAM5, MAMDC4 and HEG1, ADAM12, CEACAM5, HEG1 and IL1RAP, ADAM12, PDIA4, PEPD and FAP, PDIA4, CEACAM5, HEG1 and FAP, ADAM12, CEACAM5, PEPD and IL1RAP, AREG , TNC, ITIH3 and NCS1, FGA, TBCB, PEPD and HEG1, CEACAM5, FGA, IL17RA and HEG1, ADAM12, FGA, SLAMF8 and HEG1, ADAM12, TNC, DCXR and IL1RAP, ADAM12, CEACAM5, TBCB and HEG1, PDIA4, TNC, IGFBP2 and PKD1, CEACAM5, FGA, HEG1 and FAP, AREG, FGA, PKD1 and NCS1, ADAM12, AGR3, HEG1 and IL1RAP, AREG, FGA, HEG1 and CD55, ADAM12, PDIA4, CD55 and DCXR, AREG, PDIA4, PEPD and HEG1, PDIA4, CEACAM5, PKD1 and PEPD, AREG, FGA, SLAMF8 and HE G1, PDIA4, PKD1, AGR3 and PEPD,SERPINA1, TNC, PKD1 and PLXDC2, PDIA4, PKD1, CD34 and DCXR, AREG, CEACAM5, ADAMTSL4 and HEG1, PDIA4, PEPD, HEG1 and IL1RAP, PDIA4, CEACAM5, PEPD and DCXR, PDIA4, CEACAM5, TNC and FAP, ADAM12, FGA, AGR3 and HEG1, PDIA4, CEACAM5, HEG1 and PRDX1, SERPINA1, SLAMF8, NCS1 and PLXDC2, AREG, ADAM12, HEG1 and CD55, SERPINA1, SLAMF8, HEG1 and DCXR. AM5, FGA and MEGF9, AREG, FGA, IL17RA and HEG1, PDIA4, TBCB, PEPD and HEG1, ADAM12, TNC, MAMDC4 and PLXDC2, PDIA4, TBCB, PKD1 and MAMDC4, SERPINA1, CEACAM5, PEPD and IL1RAP, PDIA4, PEPD, FAP and PRDX1, AREG, ADAM12, FAP and IL1RAP, AREG, ADAM12, TB CB and CD55, PDIA4, TNC, MAMDC4 and NCS1, PDIA4, TNC, PKD1 and AGR3, ADAM12, TNC, FA P and IL1RAP, ADAM12, ITIH3, AGR3 and IL1RAP, SERPINA1, ADAM12, TNC and PLXDC2, AREG, AGR3, MAMDC4 and IL1RAP, SERPINA1, PDIA4, PKD1 and PLXDC2, PDIA4, IGFBP2, PEPD and FAP, PDIA4, FGA, PKD1 and MAMDC4, AREG, CEACAM5, IL17RA and HEG1, FGA, MAMDC4, SLAMF 8 and HEG1, PDIA4, IL17RA, MCAM and DCXR, PDIA4, ASPN, PKD1 and PEPD, PDIA4, TBCB, MC AM and DCXR, SERPINA1, CD34, IL1RAP and PLXDC2, ADAM12, FGA, TBCB and HEG1, SERPINA1, CEACAM5, HEG1 and PRDX1, AREG, ADAM12, IGFBP2 and CD55, PDIA4, PKD1, PEPD and HEG1, PDIA4, ITIH3, MCAM and DCXR, ADAM12, CEACAM5, FAP and IL1RAP,PDIA4, ITIH3, PKD1 and DCXR, SERPINA1, DCXR, IL1RAP and PLXDC2, CEACAM5, FGA, FAP and PRDX1, AREG, PKD1, PRTN3 and IL1RAP, SERPINA1, AREG, CD34 and DCXR, PDIA4, CEACAM5, MEGF9 and DCXR, PDIA 4, PEPD, HEG1 and DCXR, AREG, PDIA4, NCS1 and DCXR, SERPINA1, ADAMTSL4, IL1RAP and PL XDC2, PDIA4, TNC, MAMDC4 and PLXDC2, SERPINA1, TNC, MAMDC4 and PLXDC2, ADAM12, AGR3, FAP and IL1RAP, FGA, IGFBP2, HEG1 and IL1RAP, PDIA4, TBCB, CD55 and FAP, CEACAM5, TBCB, SLAMF8 and HEG1, PDIA4, ITIH3, NCS1 and MCAM, SERPINA1, TBCB, IL1RAP and PLXDC2, ADAM12, CEACAM5, TNC and HEG1, AREG, ADAM12, CD55 and IL1RAP, PDIA4, MEGF9, PEPD and FAP, PDIA4, FGA, MAMDC4 and PLXDC2, SERP INA1, PDIA4, DCXR and PLXDC2, SERPINA1, PDIA4, IL1RAP and PLXDC2, SERPINA1, ADAM12, DCXR and PLXDC2, SERPINA1, TNC, NCS1 and PLXDC2, AREG, MAMDC4, HEG1 and IL1RAP, ADAM12, CEACAM5, CD34 and PRDX1, CEACAM5, AGR3, HEG1 and IL1RAP, SERPINA1, CEACAM5, ADAMTSL4 and PEPD, PDIA4, ITIH3, PEPD and MCAM, SERPINA1, PDIA4, TBCB and PLXDC2, CEACAM5, FGA, SLAMF8 and MEGF9, PDIA4, PEP D, FAP and IL1RAP, SERPINA1, PDIA4, PEPD and FAP, SERPINA1, MEGF9, IL1RAP and PLXDC2, CEACAM5, TNC, FAP and PRDX1, AREG, ADAM12, PKD1 and AGR3, AREG, ADAM12, PKD1 and CD 55, SERPINA1, FAP, PRDX1 and DCXR, PDIA4, TNC, MAMDC4 and MCAM,PDIA4, FGA, PKD1 and HEG1, CEACAM5, TNC, HEG1 and PRDX1, PDIA4, FGA, HEG1 and ALCAM, PDIA4, IGFBP2, PKD1 and CD55, PDIA4, FGA, MAMDC4 and HEG1, SERPINA1, ADAM12, CEACAM5 and CD55, ARE G, TNC, PEPD and HEG1, SERPINA1, SLAMF8, MEGF9 and DCXR, PDIA4, MAMDC4, DCXR and ALCAM, SERPINA1, CLEC3B, SLAMF8 and DCXR, ADAM12, FGA, MAMDC4 and IL1RAP, TNC, AGR 3. HEG1 and IL1RAP, AREG, ADAMTSL4, PEPD and HEG1, SERPINA1, PDIA4, IL17RA and PLXDC2, ADAM12, FGA, FAP and CD34, SERPINA1, PDIA4, TNC and PLXDC2, SERPINA1, FGA, HEG1 and PLXDC2, AREG, ASPN, PKD1 and DCXR, AREG, TBCB, CD55 and FAP, FGA, MAMDC4, HEG1 and I L1RAP, SERPINA1, CEACAM5, AGR3 and HEG1, AREG, FGA, HEG1 and FAP, ADAM12, AGR3, SLAMF8 and IL1RAP, PDIA4, ASPN, PEPD and FAP, CEACAM5, MAMDC4, SLAMF8 and HEG1, AREG, ADAM12, CD55 and DCXR, AREG, PDIA4, DCXR and IL1RAP, SERPINA1, PKD1, IL1RAP and PLXD C2, FGA, TBCB, AGR3 and HEG1, AREG, CEACAM5, TBCB and HEG1, AREG, FGA, PKD1 and PEP D, AREG, FGA, MAMDC4 and PLXDC2, TNC, AGR3, MEGF9 and IL1RAP, SERPINA1, SLAMF8, CD55 and PLXDC2, AREG, ADAM12, DCXR and ALCAM, SERPINA1, CEACAM5, HEG1 and PLXDC2, SERPINA1, PDIA4, HEG1 and PLXDC2, AREG, TNC, AGR3 and FAP, PDIA4, MAMDC4, CD34 and DCXR, SERPINA1, AREG, MAMDC4 and PLXDC2, PDIA4, CD55, DCXR and ALCAM, AREG, ADAM 12, FGA and CD34,CEACAM5, TNC, HEG1 and IL1RAP, ADAM12, PDIA4, FAP and PRDX1, PDIA4, TBCB, MAMDC4 and CD55, PDIA4, TNC, FAP and MCAM, AREG, FGA, PKD1 and MAMDC4, PDIA4, PKD1, PRTN3 and DCXR, SERPINA1, CD55, IL1RAP and PLXDC2, SERPINA1, ADAM12, PKD1 and IL1RAP, FGA, IGFBP2, PKD1 and IL1RAP, AREG, PDIA4 , FGA and PKD1, PDIA4, MAMDC4, PEPD and HEG1, SERPINA1, PDIA4, FGA and HEG1, SERPINA1, CEACAM5, TNC and HEG1, SERPINA1, TNC, AGR3 and IL1RAP, PDIA4, TNC, HEG1 and DCXR, PDIA4, CEACAM5, TBCB and HEG1, PDIA4, CEACAM5, CD55 and ALCAM, PDIA4, ADAMTSL4, PKD1 and PEPD, AREG, AGR3, CD34 and IL1RA P, AREG, PDIA4, CD34 and DCXR, ADAM12, ITIH3, CLEC3B and IL1RAP, TNC, LRG1, AGR3 and IL1RAP, PDIA4, CEACAM5, CD34 and DCXR, PDIA4, TNC, ASPN and PEPD, PDIA4, FGA, PKD1 and PEPD, AREG, ADAMTSL4, PKD1 and IL1RAP, PDIA4, TNC, ITIH3 and MCAM, SERPINA1, ADAM12, AGR3 and IL1RAP, PDIA4, CEACAM5, CD55 and DCXR, ADAM12, PDIA4, PKD1 and AGR3, ARE G, CEACAM5, TNC and HEG1, ADAM12, CEACAM5, FGA and MEGF9, SERPINA1, PDIA4, PKD1 and PEPD, CEACAM5, TNC, MEGF9 and IL1RAP, PDIA4, SLAMF8, DCXR and ALCAM, PDIA4, IL17RA, FAP and DCXR, PDIA4, FGA, DCXR and ALCAM, PDIA4, TBCB, MAMDC4 and PLXDC2, PDIA4, TBCB, FAP and DCXR, TNC, TBCB, MAMDC4 and PLXDC2, ADAM12, CD55, FAP and PRDX1, PDIA4, TNC, FAP and PLXDC2,PDIA4, CEACAM5, HEG1 and PLXDC2, AREG, PDIA4, PEPD and FAP, PDIA4, SLAMF8, PEPD and DCXR, TNC, MAMDC4, IL1RAP and PLXDC2, PDIA4, ITIH3, PKD1 and MAMDC4, CEACAM5, ITIH3, TBCB and HEG1, PDIA4, PKD1, MAMDC4 and CD55, SERPINA1, AD AM12, CEACAM5 and NCS1, AREG, ADAM12, CEACAM5 and HEG1, ADAM12, PDIA4, PEPD and IL 1RAP, PDIA4, TNC, IL17RA and DCXR, AREG, CEACAM5, HEG1 and PRDX1, ADAM12, FGA, AG R3 and CD34, PDIA4, PKD1, CD55 and DCXR, AREG, LRG1, IL1RAP and PLXDC2, AREG, TNC, IL1RAP and PLXDC2, AREG, ADAM12, PEPD and NCS1, PDIA4, CEACAM5, PEPD and FAP, AREG, AD AM12, FAP and NCS1, AREG, TBCB, HEG1 and CD55, CEACAM5, ITIH3, ADAMTSL4 and HEG1, SE RPINA1, ADAM12, NCS1 and IL1RAP, SERPINA1, AREG, CEACAM5 and HEG1, SERPINA1, TNC, TBCB and PLXDC2, SERPINA1, AREG, CD55 and DCXR, SERPINA1, FAP, PRDX1 and IL1RAP, SERPI NA1, PDIA4, CD34 and PLXDC2, SERPINA1, SLAMF8, IL17RA and PLXDC2, PDIA4, TNC, AGR3 and FAP, PDIA4, CEACAM5, TNC and MCAM, PDIA4, CD34, DCXR and ALCAM, PDIA4, AGR3, MEG F9 and IL1RAP, PDIA4, CEACAM5, ASPN and HEG1, ADAM12, PDIA4, CD34 and DCXR, SERPINA1, CEACAM5, CLEC3B and HEG1, PDIA4, TNC, PKD1 and MCAM, PDIA4, PEPD, IL17RA and FAP, PDIA4, PEPD, FAP and MCAM, AREG, IGFBP2, PKD1 and IL1RAP, AREG, PDIA4, CD55 and ALCAM, AREG, TNC, MAMDC4 and HEG1,SERPINA1, AREG, PKD1 and IL1RAP, PDIA4, IGFBP2, PKD1 and PEPD, SERPINA1, AREG, PDIA4 and PKD1, ADAM12, FGA, HEG1 and IL1RAP, PDIA4, IGFBP2, MCAM and DCXR, ADAM12, TBCB, MAMDC4 and PLXDC2, SERPINA1, AREG, IL17RA and PLXDC2, FGA, SLAMF8, HEG1 and IL1RAP, ADAM12, LRG1, AGR3 and IL1RAP, AREG, PDIA4, FAP and DC XR, CEACAM5, HEG1, FAP and PRDX1, SERPINA1, CEACAM5, TNC and PLXDC2, AREG, PDIA4, HEG1 and CD55, PDIA4, AGR3, PEPD and FAP, ADAM12, ITIH3, FAP and PRDX1, ADAM12, MAMD C4, IL1RAP and PLXDC2, AREG, PDIA4, TBCB and NCS1, ADAM12, FGA, ITIH3 and NCS1, FGA, AGR3, MEGF9 and IL1RAP, SERPINA1, ADAM12, PKD1 and PLXDC2, PDIA4, PEPD, IL17RA and DCX R, SERPINA1, AREG, PKD1 and PLXDC2, CEACAM5, ASPN, AGR3 and HEG1, PDIA4, MAMDC4, CD55 and ALCAM, AREG, ADAM12, NCS1 and IL1RAP, SERPINA1, AREG, MEGF9 and IL1RAP, PDIA4, AGR3, PEPD and HEG1, PDIA4, TNC, FAP and IL1RAP, ADAM12, ITIH3, PKD1 and PRDX1, AD AM12, ITIH3, NCS1 and IL1RAP, ADAM12, ITIH3, PKD1 and IL1RAP, SERPINA1, CEACAM5, MEG F9 and IL1RAP, PDIA4, MAMDC4, CD55 and ALCAM, AREG, ADAM12, NCS1 and IL1RAP, 3 and IL1RAP, SERPINA1, FGA, HEG1 and IL1RAP, TNC, AGR3, FAP and IL1RAP, ADAM12, SLAMF 8, DCXR and ALCAM, PDIA4, ITIH3, PEPD and HEG1, AREG, TNC, FAP and IL1RAP, SERPINA1, SLAMF8, IL17RA and DCXR,ADAM12, ITIH3, CLEC3B and NCS1, SERPINA1, CLEC3B, FAP and PRD X1, PDIA4, TBCB, MAMDC4 and MCAM, PDIA4, IGFBP2, CD55 and ALCAM, SERPINA1, TNC, IL 17RA and PLXDC2, ADAM12, CEACAM5, CLEC3B and IL1RAP, PDIA4, TNC, IL17RA and MCAM, AREG, PDIA4, CEACAM5 and CD55, ADAM12, TBCB, MAMDC4 and CD55, AREG, CEACAM5, FGA and MEGF9, SERPINA1, AREG, ADAM12 and PLXDC2, SERPINA1, PKD1, DCXR and IL1RAP, SERPI NA1, MAMDC4, IL17RA and PLXDC2, PDIA4, TBCB, PKD1 and PEPD, FGA, AGR3, HEG1 and IL1RAP, ADAM12, CEACAM5, TNC and NCS1, SERPINA1, CEACAM5, SLAMF8 and DCXR, PDIA4, TN C, PKD1 and PLXDC2, AREG, TNC, AGR3 and MEGF9, PDIA4, TNC, ASPN and MCAM, ADAM12, CEACAM5, CD34 and IL1RAP, ADAM12, TNC, AGR3 and FAP, PDIA4, TNC, FAP and DCXR, AREG, ADAM12, AGR3 and NCS1, ADAM12, FGA, AGR3 and NCS1, CEACAM5, PKD1, SLAMF8 and DCXR, PDIA4, PEPD, FAP and CD34, SERPINA1, SLAMF8, PEPD and PLXDC2, AREG, ADAM12, MAMDC 4 and NCS1, PDIA4, IL17RA, CD55 and ALCAM, PDIA4, PEPD, MCAM and DCXR, PDIA4, FGA, HE G1 and IL1RAP, SERPINA1, CEACAM5, PKD1 and DCXR, ADAM12, FGA, PEPD and HEG1, PDIA4, PKD1, PEPD and FAP, PDIA4, CEACAM5, HEG1 and MCAM, SERPINA1, PKD1, DCXR and PLXDC2, PDIA4, PKD1, MEGF9 and DCXR, AREG, FGA, CLEC3B and HEG1, SERPINA1, AGR3, IL1RAP and PL XDC2, ADAM12, PDIA4, FGA and PEPD,AREG, PDIA4, CD55 and PLXDC2, SERPINA1, FGA, IL1RAP and PLXDC2, PDIA4, PKD1, PEPD and ALCAM, SERPINA1, FGA, CLEC3B and HEG1, PDIA4, ADAMTSL4, DCXR and ALCAM, TNC, IGFBP2, PKD1 and IL1RAP, PDIA4, TNC, PKD1 and FAP, SERPINA1, PDIA4, PEPD and HEG1, PDIA4, CEACAM5, MEGF9 and NCS1, SERPINA1, SLAMF8, DCX R and ALCAM, CEACAM5, SLAMF8, HEG1 and PRDX1, ADAM12, PDIA4, MAMDC4 and PLXDC2, AREG, ADAM12, MCAM and DCXR, CEACAM5, TNC, PEPD and FAP, ADAM12, TNC, IGFBP2 and NCS1, CEACAM5, FGA, CLEC3B and IL1RAP, CEACAM5, FGA, MEGF9 and PRDX1, SERPINA1, CE ACAM5, TBCB and PLXDC2, AREG, FGA, ITIH3 and HEG1, PDIA4, TNC, CD55 and FAP, SERPINA1, AGR3, SLAMF8 and HEG1, FGA, ASPN, AGR3 and HEG1, PDIA4, FGA, AGR3 and HEG1, ADAM12, PKD1, SLAMF8 and DCXR, AREG, TNC, MAMDC4 and CD55, SERPINA1, CEACAM5, PRDX1 and DC XR, PDIA4, MAMDC4, CD55 and DCXR, PDIA4, CEACAM5, TBCB and FAP, ADAM12, PDIA4, CE ACAM5 and DCXR, SERPINA1, CLEC3B, AGR3 and IL1RAP, CEACAM5, TBCB, ADAMTSL4 and HEG1, SERPINA1, MAMDC4, HEG1 and PLXDC2, PDIA4, PKD1, FAP and DCXR, PDIA4, CD34, MCAM and DCXR, AREG, PKD1, MAMDC4 and DCXR, ADAM12, PDIA4, PEPD and HEG1, AREG, ADAM12, AGR3 and IL1RAP, PDIA4, FGA, MCAM and DCXR, AREG, CEACAM5, PEPD and HEG1, ADAM12, CLEC3B, TBCB and CD34, SERPINA1, PDIA4, DCXR and ALCAM, AREG, FGA, PRTN3 and HEG1,SERPINA1, TNC, FAP and PLXDC2, CEACAM5, TNC, PEPD and HEG1, AREG, ADAM12, NCS1 and PLXDC2, TNC, ITIH3, MAMDC4 and PLXDC2, PDIA4, ITIH3, PKD1 and AGR3, PDIA4, PKD1, MAM DC4 and PRDX1, CEACAM5, TNC, HEG1 and FAP, ADAM12, PDIA4, CD55 and ALCAM, SERPINA1, PDIA4, CLEC3B and IL17RA, FGA, SLAMF8, HEG1 and DCXR, SERPINA1, FGA, PEPD and HEG1, ADAM12, CEACAM5, ITIH3 and IL1RAP, TNC, IGFBP2, MCAM and IL1RAP, CEACAM5, TNC, MAM DC4 and CD55, ADAM12, CEACAM5, HEG1 and FAP, AREG, PDIA4, PKD1 and IL1RAP, ADAM12, PDIA4, PKD1 and PEPD, FGA, CLEC3B, HEG1 and IL1RAP, CEACAM5, TNC, AGR3 and FAP, ADAM12, CEACAM5, CLEC3B and HEG1, AREG, PDIA4, TNC and FAP, ADAM12, CEACAM5, CD34 and DC XR, PDIA4, CEACAM5, HEG1 and IL1RAP, PDIA4, MAMDC4, MCAM and DCXR, ADAM12, CEAC AM5, IL1RAP and PLXDC2, ADAM12, PEPD, DCXR and IL1RAP, AREG, PDIA4, FGA and NCS1, AREG, FGA, ASPN and PKD1, AREG, AGR3, MEGF9 and IL1RAP, PDIA4, TBCB, DCXR and ALCAM, PDIA4, PKD1, PRDX1 and DCXR, AREG, PKD1, CD55 and DCXR, SERPINA1, PRTN3, IL1RAP and PL XDC2, SERPINA1, FGA, AGR3 and HEG1, ADAM12, ITIH3, PEPD and IL1RAP, ADAM12, CEACAM 5. TBCB and CD34, PDIA4, FGA, IGFBP2 and MCAM, PDIA4, IGFBP2, PKD1 and PRDX1, SERPINA1, AREG, ADAM12 and NCS1, SERPINA1, AREG, PDIA4 and CD55, ADAM12, TNC, NCS1 and PLXDC2, PDIA4, CEACAM5, HEG1 and NCS1,PDIA4, PKD1, PEPD and MCAM, SERPINA1, PDIA4, CEACAM5 and IL17RA, PDIA4, TBCB, MAMDC4 and HEG1, PDIA4, MAMDC4, HEG1 and CD55, FGA, TBC B, SLAMF8 and HEG1, SERPINA1, PDIA4, SLAMF8 and PLXDC2, CEACAM5, FGA, IGFBP2 and PRD X1, ADAM12, AGR3, CD34 and IL1RAP, AREG, PDIA4, TNC and HEG1, PDIA4, CEACAM5, ADA MTSL4 and HEG1, SERPINA1, CEACAM5, CD55 and DCXR, PDIA4, CEACAM5, CD34 and ALCAM, PDIA4, PEPD, HEG1 and MCAM, SERPINA1, AREG, CD55 and PLXDC2, AREG, ADAMTSL4, PKD1 and PEPD, SERPINA1, AREG, ADAM12 and CD55, ADAM12, CEACAM5, HEG1 and CD55, ADAM12, TNC, PKD1 and MAMDC4, PDIA4, ADAMTSL4, PEPD and HEG1, ADAM12, CEACAM5, SLAMF8 and HEG1, CEACAM5, HEG1, PRDX1 and DCXR, SERPINA1, CEACAM5, TNC and PKD1, AREG, ADA M12, LRG1 and NCS1, AREG, SLAMF8, PEPD and DCXR, SERPINA1, CEACAM5, IL17RA and PRDX1, AREG, ADAM12, FAP and PRDX1, ADAM12, ITIH3, CLEC3B and CD55, SERPINA1, TNC, AGR3 and MEGF9, ADAM12, FGA, ASPN and HEG1, AREG, ADAM12, AGR3 and HEG1, CEACAM5, FGA, PKD1 and HEG1, AREG, PKD1, MCAM and DCXR, AREG, TNC, MCAM and IL1RAP, ADAM12, TNC, IL1RAP and PLXDC2, PDIA4, FGA, FAP and PRDX1, ADAM12, TBCB, FAP and IL1RAP, PDIA4, CE ACAM5, AGR3 and MEGF9, PDIA4, PEPD, FAP and NCS1, PDIA4, AGR3, MAMDC4 and HEG1, ADA M12, CLEC3B, DCXR and IL1RAP, SERPINA1, CEACAM5, HEG1 and CD34,ADAM12, CEACAM5, HEG1 and PLXDC2, SERPINA1, MAMDC4, DCXR and PLXDC2, AREG, ITIH3, PKD1 and DCXR, ARE G, PDIA4, CD55 and DCXR, ADAM12, CEACAM5, ITIH3 and HEG1, PDIA4, CEACAM5, PKD1 and HEG1, AREG, TNC, PKD1 and IL1RAP, PDIA4, MAMDC4, FAP and PRDX1, CEACAM5, TNC, TBCB and HEG1, SERPINA1, AREG, FGA and PKD1, CEACAM5, TNC, MAMDC4 and HEG1, ADAM12, FG A, PKD1 and MAMDC4, PDIA4, SLAMF8, PEPD and HEG1, ADAM12, FGA, FAP and NCS1, SERPINA1, AREG, PRDX1 and PLXDC2, PDIA4, CEACAM5, MAMDC4 and DCXR, PDIA4, TNC, PKD1 and HEG1, ADAM12, PDIA4, MAMDC4 and CD34, CEACAM5, MEGF9, PRTN3 and IL1RAP, SERPINA1, TBCB, MAMDC4 and PLXDC2, PDIA4, IGFBP2, P EPD and HEG1, SERPINA1, CEACAM5, CLEC3B and IL17RA, AREG, CEACAM5, HEG1 and DCXR, CEACAM5, TBCB, AGR3 and HEG1, AREG, TNC, TBCB and FAP, PDIA4, FAP, PRDX1 and DCXR, PDIA4, CEACAM5, SLAMF8 and HEG1, SERPINA1, IL17RA, IL1RAP and PLXDC2, PDIA4, CEACAM5, PEPD and MCAM, PDIA4, MAMDC4, CD55 and FA P, AREG, ADAM12, SLAMF8 and DCXR, AREG, PDIA4, TBCB and CD55, SERPINA1, ADAM12, CEACAM5 and HEG1, CEACAM5, ADAMTSL4, MAMDC4 and HEG1, PDIA4, PKD1, MCAM and DCXR, AREG, FGA, MAMDC4 and NCS1, ADAM12, ITIH3, NCS1 and PLXDC2, AREG, TNC, IGFBP2 and NCS1, AREG, ADAM12, HEG1 and NCS1, PDIA4, TNC, PEPD and HEG1, PDIA4, CEACAM5, MEGF 9 and HEG1,AREG, PDIA4, IL17RA and NCS1, SERPINA1, FGA, ADAMTSL4 and HEG1, AREG, PDIA4, CD55 and MCAM, ADAM12, PDIA4, CEACAM5 and PEPD, PDIA4, FGA, AGR3 and FAP, TNC, MAMDC4, SLAMF8 and DCXR, ADAM12, CEACAM5, TBCB and CD55, SERPINA1, ADAM12, TNC and NCS1, SERPINA1, ADAM12, DCXR and IL1RAP, AREG, SLAMF8, MCAM and DCXR, PDIA4, ADAMTSL4, PKD1 and MAMDC4, ADAM12, CEACAM5, HEG1 and CD34, ADAM12, ITIH3, DCXR and IL1RAP, FGA, CLEC3B, TBCB and HEG1, ADAM12, CE ACAM5, TBCB and NCS1, PKD1, MAMDC4, SLAMF8 and DCXR, PDIA4, MCAM, PRDX1 and DCXR, AREG, PDIA4, ADAMTSL4 and PKD1, AREG, PDIA4, CD55 and IL1RAP, ADAM12, MAMDC4, FAP and IL1RAP, SERPINA1, PDIA4, AGR3 and PLXDC2, ADAM12, TBCB, CD55 and FAP, SERPINA1, IL17RA, DCXR and PLXDC2, SERPINA1, TBCB, PEPD and PLXDC2, AREG, ADAM12, TBCB and DCXR, SERPINA1, AREG, DCXR and IL1RAP, SERP INA1, CEACAM5, SLAMF8 and PLXDC2, AREG, ADAM12, IGFBP2 and NCS1, ADAM12, IGFBP2, AGR3 and IL1RAP, ADAM12, FGA, CLEC3B and HEG1, PDIA4, TNC, TBCB and MCAM, AREG, FGA, PKD1 and AGR3, SERPINA1, CEACAM5, ADAMTSL4 and HEG1, IGFBP2, PKD1, SLAMF8 and DCXR, SERPINA1, ADAM12, SLAMF8 and DCXR, PDIA4, TNC, MEGF9 and PEPD, AREG, TNC, FGA and HEG1, PDIA4, SLAMF8, HEG1 and DCXR, PDIA4, TBCB, CD55 and ALCAM, AREG, PDIA4, ASPN and PKD1, PDIA4, AGR3, CD55 and FAP,PDIA4, PEPD, CD55 and FAP, ADAM12, CD34, DCXR and IL1RAP, AREG, PDIA4, CEACAM5 and DCXR, ADAM12, CEACAM5, MEGF9 and IL1RAP, CEACAM 5, ITIH3, SLAMF8 and HEG1, AREG, PDIA4, PKD1 and PEPD, PDIA4, CLEC3B, DCXR and ALCAM, SERPINA1, CEACAM5, NCS1 and PLXDC2, FGA, IGFBP2, PKD1 and HEG1, AREG, SLAMF8, NCS1 and DCXR, SERPINA1, CEACAM5, IL17RA and DCXR, SERPINA1, ADAM12, CEACAM5 and IL1RAP, AREG, PDIA4, AGR3 and CD55, AREG, CEAC AM5, MAMDC4 and HEG1, PDIA4, IGFBP2, CLEC3B and PKD1, ADAM12, FGA, IGFBP2 and NCS1, SERPINA1, ADAM12, MAMDC4 and PLXDC2, AREG, ADAM12, CEACAM5 and NCS1, PDIA4, ITIH3, DCXR and ALCAM, SERPINA1, SLAMF8, MCAM and DCXR, AREG, ADAM12, PDIA4 and NCS1, AREG, FGA, HEG1 and CD34, SERPINA1, AREG, ADAM12, MAMDC4 and PLXDC2 M12 and PKD1, ADAM12, PDIA4, CEACAM5 and HEG1, ADAM12, CEACAM5, SLAMF8 and NCS1, SERPINA1, FGA, HEG1 and PRDX1, PDIA4, TNC, PEPD and MCAM, ADAM12, TNC, FAP and NCS1, AREG, ADAM12, NCS1 and ALCAM, ADAM12, FGA, ITIH3 and HEG1, AREG, PDIA4, TNC and PKD 1, AREG, SLAMF8, CD55 and DCXR, SERPINA1, PDIA4, PEPD and IL17RA, ADAM12, CEACAM5, FGA and FAP, AREG, TNC, HEG1 and NCS1, SERPINA1, CEACAM5, DCXR and PLXDC2, CEACAM5, TNC, ITIH3 and HEG1, PDIA4, TNC, FGA and MCAM, AREG, PDIA4, PKD1 and CD55, AREG, CD34, MCAM and DCXR, SERPINA1, PKD1, PRTN3 and DCXR, AREG, PKD1, MAMDC4 and PRDX1,AREG, PDIA4, CD55 and FAP, PDIA4, ASPN, PKD1 and DCXR, AREG, CEACAM5, HEG1 and CD55, SERPI NA1, TBCB, CD55 and PLXDC2, AREG, ADAM12, ASPN and CD55, AREG, ADAMTSL4, PEPD and IL1RAP, TNC, ITIH3, FAP and PRDX1, PDIA4, FGA, AGR3 and MEGF9, AREG, PDIA4, ITIH3 and NC S1, PDIA4, HEG1, MCAM and DCXR, AREG, IGFBP2, ADAMTSL4 and PKD1, SERPINA1, PDIA4, ASPN and PLXDC2, ADAM12, TNC, ITIH3 and NCS1, AREG, LRG1, PKD1 and DCXR, TNC, FGA, MAMDC4 and HEG1, SERPINA1, MAMDC4, FAP and PRDX1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4, TNC, TBCB and PKD1, PDIA4, PKD1, DCXR and PLXDC2, AREG, TNC, PKD1 and HEG1, PDIA4, ASPN, PEPD and HEG1, AREG, ADAM12, CD55 and NCS1, AREG, TNC, PKD1 and PEPD, SERP INA1, TNC, AGR3 and PLXDC2, CEACAM5, FGA, AGR3 and MEGF9, AREG, FGA, MCAM and DCX R, AREG, SLAMF8, HEG1 and DCXR, SERPINA1, CEACAM5, PEPD and PLXDC2, ADAM12, PDIA4, MCAM and DCXR, PDIA4, PKD1, MAMDC4 and PLXDC2, PDIA4, MAMDC4, IL1RAP and PLXDC2, CEACAM5, TBCB, MAMDC4 and CD55, SLAMF8, MCAM, DCXR and IL1RAP, SERPINA1, SLAMF8, MEGF9 and IL1RAP, AM12, ITIH3, CD34 and NCS1, SERPINA1, CEACAM5, PEPD and HEG1, PDIA4, FGA, ITIH3 and PKD 1, PDIA4, MCAM, DCXR and IL1RAP, ADAM12, TNC, TBCB and FAP, AREG, TBCB, ADAMTSL4 and PKD1, AREG, ADAM12, TBCB and NCS1,ADAM12, PDIA4, FGA and HEG1, SERPINA1, CLEC3B, CD34 and IL1RAP, SERPINA1, TNC, HEG1 and PLXDC2, SERPINA1, AREG, MEGF9 and CD55, PDIA4, FGA, ASPN and HEG1, PDIA4, PEPD, CD34 and DCXR, AREG, AGR3, HEG1 and IL1RAP, PD IA4, TNC, ITIH3 and FAP, SERPINA1, AREG, TBCB and PLXDC2, SERPINA1, CLEC3B, IL17RA and IL1RAP, PDIA4, PKD1, CD55 and ALCAM, AREG, FGA, MEGF9 and IL1RAP, SERPINA1, TNC, FA P and PRDX1, PDIA4, MAMDC4, HEG1 and MCAM, ADAM12, FGA, PEPD and FAP, CEACAM5, IGF BP2, SLAMF8 and HEG1, ADAM12, AGR3, IL1RAP and PLXDC2, SERPINA1, ADAM12, FGA and NCS 1, PDIA4, CD55, DCXR and IL1RAP, SERPINA1, TNC, CLEC3B and IL17RA, PDIA4, PKD1, PEPD and NCS1, CEACAM5, FGA, MEGF9 and DCXR, PDIA4, MEGF9, DCXR and ALCAM, PDIA4, MAMD C4, MCAM and PRDX1, PDIA4, TBCB, FAP and PRDX1, FGA, MAMDC4, HEG1 and MCAM, PDIA4, PKD1, MAMDC4 and PEPD, AREG, IGFBP2, TBCB and CD55, SERPINA1, PDIA4, CEACAM5 and PEP D, PDIA4, HEG1, DCXR and ALCAM, PDIA4, TNC, HEG1 and MCAM, PDIA4, IGFBP2, TBCB and MCAM, PDIA4, TNC, HEG1 and FAP, SERPINA1, AREG, AGR3 and IL1RAP, SERPINA1, PDIA4, MA MDC4 and CD55, AREG, ADAM12, AGR3 and CD55, ADAM12, FGA, HEG1 and PRDX1, PDIA4, CEA CAM5, TNC and PKD1, PDIA4, IL17RA, CD55 and DCXR, AREG, TNC, MEGF9 and CD55, AREG, ADAMTSL4, PEPD and NCS1, FGA, IGFBP2, PKD1 and DCXR,AREG, TNC, MEGF9 and NCS1, PDIA4, MAMDC4, HEG1 and DCXR, PDIA4, MAMDC4, IL17RA and DCXR, SERPINA1, FGA, CLEC3B and IL 17RA, ADAM12, TNC, MAMDC4 and FAP, AREG, ADAM12, SLAMF8 and NCS1, SERPINA1, MAM DC4, PLXDC2 and ALCAM, PDIA4, PKD1, SLAMF8 and PEPD, PDIA4, TNC, FAP and PRDX1, PDIA4, TNC, MAMDC4 and DCXR, PDIA4, PKD1, HEG1 and DCXR, ADAM12, TNC, ITIH3 and PKD1, SERPINA1, SLAMF8, CD55 and DCXR, CEACAM5, TNC, ADAMTSL4 and HEG1, CEACAM5, ADAMTSL4, PEPD and HEG1, PDIA4, ASPN, ADAMTSL4 and PEPD, AREG, FGA, PKD1 and MEGF9, PDIA4, MA MDC4, FAP and PLXDC2, SERPINA1, ADAM12, TBCB and PLXDC2, AREG, FGA, LRG1 and HEG1, SERPINA1, ADAM12, CD34 and PLXDC2, PDIA4, ASPN, PKD1 and AGR3, SERPINA1, CEACAM5, TNC and MEGF9, PDIA4, TBCB, FAP and IL1RAP, FGA, IGFBP2, PKD1 and PEPD, SERPINA1, AREG, IL17RA and CD55, PDIA4, TNC, DCXR and ALCAM, PDIA4, CEACAM5, HEG1 and CD34, TNC, AGR 3. MAMDC4 and FAP, PDIA4, TBCB, HEG1 and DCXR, PDIA4, TNC, PEPD and PLXDC2, PDIA4, PKD1, PEPD and IL1RAP, PDIA4, CEACAM5, TNC and DCXR, AREG, ADAM12, TNC and PKD1, PDIA4, ASPN, PEPD and CD55, AREG, IGFBP2, PRTN3 and CD55, SERPINA1, AGR3, MEGF9 and IL1RA P, ADAM12, FGA, NCS1 and IL1RAP, FGA, MAMDC4, SLAMF8 and PLXDC2, SERPINA1, PDIA4, TBCB and CD55, AREG, PDIA4, CEACAM5 and PKD1, PDIA4, ITIH3, PKD1 and NCS1,SERPINA1, CEACAM5, CD55 and PLXDC2, SERPINA1, ADAM12, CEACAM5 and PEPD, AREG, FGA, IGFBP2 and NCS1, PDIA4, CEACAM5, TNC and MEGF9, AREG, TNC, AGR3 and NCS1, CEACAM5, ASPN, TBC B and HEG1, ADAM12, TNC, MAMDC4 and NCS1, PDIA4, PKD1, AGR3 and MAMDC4, or AREG, ADAM12, PDIA4 and DCXR (i.e., 886 4-markers combinations in Table 6).

[0030] Preferably, the 4 markers combination is: CEACAM5, FGA, PEPD and HEG1, AREG, CEACAM5, FGA and HEG1, ADAM12, CEACAM5, FGA and HEG1, PDIA4, CEACAM5, PEPD, HEG1, CEACAM5, FGA, HEG1 and PRDX1, AREG, PDIA4, DCXR and ALCAM, SERPINA1, CEACAM5, FGA and HEG1, AREG, FGA, HEG1 and IL1RAP, AREG, FGA, PEPD and HEG1, ADAM12, PDIA4, DCXR and ALCAM, PDIA 4, PKD1, DCXR and IL1RAP, SERPINA1, ADAM12, FAP and PRDX1, PDIA4, TNC, PEPD and FAP, SERPINA1, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, PEPD and DCXR, AREG, PDIA4, PKD1 and DC XR, PDIA4, CEACAM5, PKD1 and DCXR, PDIA4, PEPD, FAP and DCXR, SERPINA1, AREG, IL1RAP and PLXDC2, PDIA4, TBCB, PEPD and FAP, AREG, PDIA4, CEACAM5 and HEG1, AREG, ADAM12, FAP and HEG1, SERPINA1, CEACAM5, IL1RAP and PLXDC2, PDIA4, FGA, PKD1 and DCXR, PD IA4, CEACAM5, DCXR and ALCAM, ADAM12, FGA, MAMDC4 and HEG1, PDIA4, FGA, IGFBP2 and PKD1, ADAM12, LRG1, FAP and PRDX1, CEACAM5, TNC, FGA and HEG1, ADAM12, FGA, AGR3 and IL1RAP, SERPINA1, MAMDC4, IL1RAP and PLXDC2, PDIA4, TNC, MCAM and DCXR, SERPINA 1. ADAM12, IL1RAP and PLXDC2, ADAM12, CEACAM5, FAP and PRDX1, AREG, ADAM12, PKD1 and DCXR, AREG, PKD1, SLAMF8 and DCXR, TNC, AGR3, MAMDC4 and IL1RAP, ADAM12, TBCB, FAP and PRDX1, PDIA4, CLEC3B, PKD1 and DCXR, PDIA4, FGA, PEPD and HEG1, PDIA4, PEPD, HEG1 and FAP, ADAM12, FGA, FAP and PRDX1,ADAM12, PDIA4, PKD1 and DCXR, PDIA4, SLAMF8, MCAM and DCXR, PDIA4, DCXR, IL1RAP and ALCAM, ADAM12, PEPD, FAP and PRDX1, SERPINA1, AREG, FGA and HEG1, PDIA4, TNC, IGFBP2 and MCAM, SERPINA1, AREG, PKD1 and DCXR, ARE G, TNC, MAMDC4 and NCS1, ADAM12, FAP, PRDX1 and DCXR, AREG, ADAM12, TNC and NCS1, PDIA4, IGFBP2, PKD1 and DCXR, PDIA4, IL17RA, DCXR and ALCAM, ADAM12, CLEC3B, AGR3 and IL1RAP, CEACAM5, AGR3, SLAMF8 and HEG1, SERPINA1, TNC, DCXR and PLXDC2, FGA, AG R3, SLAMF8 and HEG1, PDIA4, CEACAM5, MEGF9 and PEPD, PDIA4, TNC, MAMDC4 and CD55, CEACAM5, SLAMF8, PEPD and HEG1, SERPINA1, SLAMF8, DCXR and PLXDC2, SERPINA1, PEPD, IL1RAP and PLXDC2, SERPINA1, CEACAM5, CLEC3B and PRDX1, PDIA4, TNC, ITIH3 and PKD1, ADAM12, FGA, SLAMF8 and NCS1, TNC, CLEC3B, AGR3 and IL1RAP, PDIA4, TBCB, PKD1 and DCX R, PDIA4, FAP, DCXR and ALCAM, CEACAM5, AGR3, HEG1 and PRDX1, SERPINA1, PDIA4, PK D1 and DCXR, ADAM12, TNC, AGR3 and IL1RAP, PDIA4, PKD1, PRTN3 and PEPD, ADAM12, PDIA 4, CD55 and FAP, ADAM12, CEACAM5, DCXR and IL1RAP, SERPINA1, MEGF9, PRTN3 and IL1RAP, AREG, ADAM12, HEG1 and IL1RAP, AREG, MAMDC4, IL1RAP and PLXDC2, CEACAM5, ADAMTS L4, SLAMF8 and HEG1, ADAM12, AGR3, MAMDC4 and IL1RAP, FGA, CLEC3B, MAMDC4 and HEG1, PDIA4, ITIH3, PEPD and FAP, AREG, ADAM12, IL1RAP and PLXDC2,CEACAM5, ADAMTSL4, HE G1 and PRDX1, FGA, TBCB, MAMDC4 and HEG1, ADAM12, SLAMF8, DCXR and IL1RAP, SERPINA1, PDIA4, CEACAM5 and HEG1, AREG, TBCB, PKD1 and DCXR, AREG, CEACAM5, HEG1 and IL1RAP, PDIA4, ITIH3, PKD1 and PEPD, SERPINA1, TBCB, SLAMF8 and PLXDC2, AREG, TNC, PKD1 and MAMDC4, SERPINA1, PDIA4, MAMDC4 and PLXDC2, ADAM12, DCXR, IL1RAP and ALCAM, FGA, SLAMF8, PEPD and HEG1, PDIA4, IGFBP2, DCXR and ALCAM, SERPINA1, SLAMF8, PEPD and DCX R, PDIA4, ADAMTSL4, PKD1 and DCXR, ADAM12, TNC, FAP and PRDX1, SERPINA1, CLEC3B, IL1RAP and PLXDC2, PDIA4, PRTN3, PEPD and FAP, CEACAM5, SLAMF8, HEG1 and DCXR, PDIA4, MCAM, DCXR and ALCAM, SERPINA1, CEACAM5, HEG1 and IL1RAP, SERPINA1, HEG1, IL1RAP and PLXDC2, AREG, PKD1, DCXR and IL1RAP, AREG, ADAM12, PDIA4 and CD55, ADAM12, MAM DC4, FAP and PRDX1, PDIA4, PEPD, DCXR and IL1RAP, or PDIA4, IGFBP2, CD55 and MCAM (i.e., the 110 4-markers combinations in italics in Table 6).

[0031] Preferably, the A comprises a combination of 5 markers, and the combination of 5 markers is any five of the combinations in B.

[0032] Preferably, the 5 markers are combined into a1) and a2):

[0033] a1) the 4-markers combination (preferably any one of the 110 4-markers combinations mentioned above);

[0034] a2) any one of the above B;

[0035] The a2) is different from any one of the markers in the combination of 4 markers in a1).

[0036] Preferably, the 5 markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC, PDIA4, PKD1, PEPD, DCXR and TBCB, CEACAM5, TNC, FGA, HEG1 and DCXR, PDIA4, PEPD, DCXR, IL1RAP and TNC, CEACAM5, FGA, PEPD, HEG1 and SERPINA1, ADAM12, PEPD, FAP, PRDX1 and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC, PDIA4, PRTN3, PEPD, FAP and DCXR, SERPINA1, ADAM12, IL1RAP, PLXDC2 and TBCB, ADAM12, PDIA4, DCXR, ALCAM and NCS1. R3, MAMDC4, IL1RAP and LRG1, CEACAM5, ADAMTSL4, HEG1, PRDX1 and PDIA4, PDIA4, PKD1, PEPD, DCXR and MAMDC4, SERPINA1, AREG, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PEPD, FAP, DCXR and MCAM, TNC, AGR3, MAMDC4, IL1RAP and CLEC3B, ADAM12, AGR3, MAMDC4, IL1RAP and SERPINA1, AREG, ADAM12, TNC, N CS1 and PEPD, PDIA4, PEPD, HEG1, FAP and TNC, PDIA4, PKD1, PEPD, DCXR and FAP, SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4, PDIA4, PEPD, FAP, DCXR and TBCB, SERPINA1, CEACAM5, FGA, HEG1 and MAMDC4, PDIA4, PKD1, PRTN3, PEPD and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and ADAMTSL4, ADAM12, MAMD C4, FAP, PRDX1 and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and NCS1, PDIA4, PEPD, HEG1, FAP and DCXR, CEACAM5, SLAMF8, PEPD, HEG1 and ADAM12, AREG, PDIA4, DCXR, ALCAM and MAMDC4, PDIA4, PKD1, DCXR, IL1RAP and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and MAM DC4, PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4,ADAM12, FGA, MAMDC4, HEG1 and TBC B, AREG, PDIA4, PKD1, DCXR and MAMDC4, AREG, PDIA4, PKD1, DCXR and TNC, CEACAM5, AGR3, HEG1, PRDX1 and SLAMF8, PDIA4, PKD1, PEPD, DCXR and SERPINA1, ADAM12, DCXR, IL1RAP, ALCAM and TNC, CEACAM5, AGR3, SLAMF8, HEG1 and TBCB, PDIA4, ADAMTSL4, PK D1, DCXR and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and DCXR, PDIA4, FAP, DCXR, ALC AM and PEPD, TNC, AGR3, MAMDC4, IL1RAP and ALCAM, AREG, PKD1, SLAMF8, DCXR and IGF BP2, TNC, AGR3, MAMDC4, IL1RAP and MCAM, ADAM12, AGR3, MAMDC4, IL1RAP and SLAMF 8, ADAM12, PDIA4, DCXR, ALCAM and CLEC3B, PDIA4, IL17RA, DCXR, ALCAM and AGR3, PD IA4, MCAM, DCXR, ALCAM and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and DCXR, SERPIN A1, HEG1, IL1RAP, PLXDC2 and DCXR, PDIA4, TNC, PEPD, FAP and MCAM, AREG, TBCB, PK D1, DCXR and CEACAM5, SERPINA1, PDIA4, PKD1, DCXR and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and TNC, ADAM12, FGA, MAMDC4, HE G1, ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and TNC, AREG, MAMDC4, IL1RAP, PLXDC 2 and FAP, TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4, PDIA4, PKD1, PEPD, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and MAMDC4, PDIA4, IGFBP2, PKD1, DCXR and MAMDC4, CEACAM 5. AGR3, HEG1, PRDX1 and MAMDC4, FGA, SLAMF8, PEPD, HEG1 and SERPINA1,AREG, ADAM12, PDIA4, CD55 and DCXR, PDIA4, PEPD, FAP, DCXR and SERPINA1, ADAM12, MAMDC4, FAP, PRDX1 and TBCB, ADAM12, FGA, AGR3, IL1RAP and CEACAM5, PDIA4, PKD1, DCXR, IL1RAP and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MCAM, SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and MCAM, PDIA4, CEACAM5, DCXR, ALCAM and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and TB CB, ADAM12, PEPD, FAP, PRDX1 and IL17RA, AREG, ADAM12, TNC, NCS1 and DCXR, PDIA4, CLEC3B, PKD1, DCXR and PEPD, AREG, FGA, HEG1, IL1RAP and PDIA4, SERPINA1, PKD1, SLA MF8, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and TBCB, ADAM12, FAP, PRDX1, DCXR and PEPD, AREG, PDIA4, PKD1, DCXR and NCS1, PDIA4, PEPD, DCXR, IL1RAP and MCAM, AREG, TNC, MAMDC4, NCS1 and TBCB, PDIA4, PKD1, PRTN3, PEPD and ADAMTSL4, ADAM12, AGR3, MAMDC4, IL1RAP and CEACAM5, SERPINA1, AREG, FGA, HEG1 and MAMDC4, PDIA4, TBCB, PKD1, DCXR and ALCAM , PDIA4, TBCB, PEPD, FAP and TNC, CEACAM5, AGR3, HEG1, PRDX1 and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and LRG1, ADAM12, FGA, MAMDC4, HEG1 and SERPINA1, FGA, AGR3, SLAMF8, HEG1 and TNC, AREG, PDIA4, CEACAM5, HEG1 and MAMDC4, ADAM12, CEACAM5, FGA, HEG1 and IL17RA, AREG, MAMDC4, IL1RAP, PLXDC2 and TBCB, SERPINA1, CEACAM5, FGA, HEG1 and PDIA4,ADAM12, AGR3, MAMDC4, IL1RAP and FAP, ADAM 12, PDIA4, PKD1, DCXR and PEPD, ADAM12, AGR3, MAMDC4, IL1RAP and MCAM, AREG, FGA, PEPD, HEG1 and TBCB, PDIA4, TNC, MCAM, DCXR and PEPD, ADAM12, FGA, AGR3, IL1RAP and MAMDC4, PDIA4, CEACAM5, DCXR, ALCAM and PRDX1, SERPINA1, AREG, FGA, HEG1 and IL17RA, AREG, TNC, PKD1, MAMDC4 and NCS1, TNC, AGR3, MAMDC4, IL1RAP and DCXR, TNC, AGR3, MAMDC4, IL1RAP and FAP, AREG, CEACAM5, FGA, HEG1 and PRDX1, CEACAM5, SLAM F8, PEPD, HEG1 and LRG1, PDIA4, PEPD, FAP, DCXR and CEACAM5, FGA, AGR3, SLAMF8, HE G1 and TBCB, AREG, FGA, PEPD, HEG1 and DCXR, PDIA4, PKD1, PEPD, DCXR and LRG1, CEACAM5, AGR3, SLAMF8, HEG1 and TNC, PDIA4, PEPD, FAP, DCXR and SLAMF8, ADAM12, FGA, MAMDC4, HEG1 and NCS1, AREG, FGA, PEPD, HEG1 and NCS1, ADAM12, FAP, PRDX1, DCXR and ALCAM, ADAM12, PEPD, FAP, PRDX1 and MCAM, ADAM12, CEACAM5, FAP, PRDX1 and PEP D, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PEPD, SERPINA1, SLAMF8, DCXR, PLXDC2 and MAMDC4, SERPINA1, PDIA4, PKD1, DCXR and ALCAM, AREG, PKD1, DCXR, IL1RAP and PDIA4, CEACAM5, AGR3, SLAMF8, HEG1 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP and SERPINA1, PDIA4, DCXR, IL1RAP, ALCAM and MCAM, PDIA4, PEPD, DCXR, IL1RAP and CEACAM5, PDIA4, TBCB, PEPD, FAP and LRG1,ADAM12, AGR3, MAMDC4, IL1RAP and ITIH3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ALCAM, ADAM12, FGA, SLAMF 8, NCS1 and ALCAM, ADAM12, TNC, AGR3, IL1RAP and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and MAMDC4, AREG, TNC, PKD1, MAMDC4 and PEPD, SERPINA1, CEACAM5, HEG1, IL1RAP and DC XR, PDIA4, ITIH3, PKD1, PEPD, HEG1 and MCAM, PDIA4, PR TN3, PEPD, FAP and LRG1, TNC, AGR3, MAMDC4, IL1RAP and PDIA4, SERPINA1, ADAM12, FA P, PRDX1 and DCXR, PDIA4, TBCB, PEPD, FAP and CEACAM5, ADAM12, FGA, MAMDC4, HEG1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and DCXR, SERPINA1, SLAMF8, PEPD, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and IL17RA, ADAM12, FGA, FAP, PRDX1 and AGR3, TNC, AGR 3, MAMDC4, IL1RAP and LRG1, PDIA4, TBCB, PKD1, DCXR and NCS1, SERPINA1, AREG, PKD1, DCXR and PDIA4, AREG, ADAM12, PDIA4, CD55 and CLEC3B, PDIA4, TNC, PEPD, FAP and CEAC AM5, ADAM12, LRG1, FAP, PRDX1 and IL17RA, FGA, TBCB, MAMDC4, HEG1 and TNC, PDIA4, CEACAM5, PEPD, HEG1 and ADAM12, PDIA4, TNC, ITIH3, PKD1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and MCAM, PDIA4, DCXR, IL1RAP, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1 and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and PEPD, PDIA4, PEPD, DCXR, IL1RAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and PEPD, ADAM12, DCXR, IL1RAP, ALCAM and NCS1,PDIA4, FAP, DCXR, ALCAM and PRDX1, SERPINA1, TNC, DCXR, PLXDC2 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and AGR3, PDIA4, TBCB, PEPD, FAP and NCS1, ADAM12, FGA, AGR 3, IL1RAP and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and FAP, PDIA4, FGA, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, SLAMF8, NCS1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and MAMDC4, AREG, ADAM12, FGA, HEG1 and ALCAM, ADAM12, PDIA4, PKD1, DCXR and ALCAM, SE RPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB, FGA, AGR3, SLAMF8, HEG1 and NCS1, PDIA4, PEPD, HEG1, FAP and SERPINA1, SERPINA1, TNC, DCXR, PLXDC2 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MCAM, SERPINA1, SLAMF8, DCXR, PLXDC2 and FAP, CEACAM5, ADAMTSL4, SL AMF8, HEG1 and MAMDC4, PDIA4, IGFBP2, DCXR, ALCAM and IL17RA, ADAM12, TNC, FAP, PRDX1 and PEPD, PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA, CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12, SERPINA1, SLAMF8, PEPD, DCXR and NCS1, PDIA4, ADAMTSL4, PKD1, DCXR and FAP, FAP, AGR3, SLAMF8, HEG1 and DCXR, PDIA 4, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and NCS1, CEACAM5, TNC, FGA, HEG1 and NCS1, ADAM12, CLEC3B, AGR3, IL1RAP and TBCB, ADAM12, PEPD, FAP, PRDX 1 and SERPINA1, ADAM12, FGA, AGR3, IL1RAP and IL17RA, SERPINA1, PDIA4, MAMDC4, PLXD C2 and NCS1,PDIA4, DCXR, IL1RAP, ALCAM and FAP, SERPINA1, AREG, PKD1, DCXR and CEAC AM5, PDIA4, FAP, DCXR, ALCAM and ITIH3, CEACAM5, AGR3, HEG1, PRDX1 and PDIA4, SERP INA1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4, IL17RA, DCXR, ALCAM and MAMDC4, PDI A4, FGA, PEPD, HEG1 and DCXR, ADAM12, LRG1, FAP, PRDX1 and ALCAM, FGA, AGR3, SLA MF8, HEG1 and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and IGFBP2, SERPINA1, TBCB, SL AMF8, PLXDC2 and MCAM, PDIA4, PEPD, FAP, DCXR and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and MCAM, SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5, AREG, PKD1, DCXR, IL1RAP and NCS1, PDIA4, CEACAM5, PKD1, DCXR and TBCB, SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP, PDIA4, FGA, IGFBP2, PKD1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1 and PKD1, PDI A4, PEPD, HEG1, FAP and MAMDC4, PDIA4, IL17RA, DCXR, ALCAM and TNC, AREG, PKD1, DCXR, IL1RAP and MAMDC4, AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3, ADAM12, AGR3, MA MDC4, IL1RAP and PRDX1, SERPINA1, PDIA4, CEACAM5, HEG1 and NCS1, ADAM12, CEACAM5, FAP, PRDX1, DCXR, AREG, PKD1, DCXR, IL1RAP and ALCAM, PDIA4, FAP, DCXR, ALCAM and MAMDC4, PDIA4, PEPD, HEG1, FAP and LRG1, ADAM12, TBCB, FAP, PRDX1 and TNC, CEAC AM5, SLAMF8, HEG1, DCXR and NCS1, CEACAM5, FGA, HEG1, PRDX1 and ALCAM, PDIA4, TN C, MCAM, DCXR and MAMDC4,FGA, CLEC3B, MAMDC4, HEG1 and PDIA4, AREG, TNC, PKD1, MAMDC4 and TBCB, AREG, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, MCAM, DCXR, ALC AM and PRDX1, ADAM12, FAP, PRDX1, DCXR and IL17RA, SERPINA1, CEACAM5, CLEC3B, PRD X1 and ALCAM, CEACAM5, FGA, PEPD, HEG1 and AGR3, PDIA4, CEACAM5, PEPD, HEG1 and SLAMF8, PDIA4, TBCB, PEPD, FAP and ALCAM, PDIA4, PEPD, FAP, DCXR and LRG1, AREG, AD AM12, PKD1, DCXR and NCS1, CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2, SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD, ADAM12, MAMDC4, FAP, PRDX1 and IL17RA, ADAM12, AGR3, MA MDC4, IL1RAP and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD, AREG, PDIA4, PKD1, DCXR and ADAMTSL4, CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B, AREG, ADAM12, FGA, HEG1 and AGR3, AREG, FGA, HEG1, IL1RAP and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and PEP D, AREG, PKD1, DCXR, IL1RAP and MCAM, PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4, AREG, ADAM12, PDIA4, CD55 and NCS1, ADAM12, FGA, AGR3, IL1RAP and TNC, SERPINA1, PEP D, IL1RAP, PLXDC2 and LRG1, AREG, PKD1, DCXR, IL1RAP and PEPD, TNC, AGR3, MAMDC4, IL1RAP and CEACAM5, AREG, TNC, MAMDC4, NCS1 and DCXR, AREG, PKD1, SLAMF8, DCXR and NCS1, AREG, TNC, MAMDC4, NCS1 and ALCAM, PDIA4, PRTN3, PEPD, FAP and ADAMTSL4, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB,CEACAM5, AGR3, SLAMF8, HEG1 and SERPI NA1, PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B, ADAM12, FGA, FAP, PRDX1 and PEPD, TNC, CLEC3B, AGR3, IL1RAP and ADAMTSL4, CEACAM5, AGR3, SLAMF8, HEG1 and ALCAM, ADAM12, CEACAM5, FAP, PRDX1 and PDIA4, AREG, PDIA4, DCXR, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and TNC, SERPINA1, PEPD, IL1RA P, PLXDC2 and MAMDC4, AREG, PKD1, SLAMF8, DCXR and TBCB, FGA, AGR3, SLAMF8, HEG1 and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4, ADAM12, FGA, AGR3, IL1RAP and ALCAM, PDIA4, PRTN3, PEPD, FAP and SERPINA1, ADAM12, CLEC3B, AGR3, IL1RAP and NCS1, SERPINA1, PKD1, SLAMF8, DCXR and TBCB, ADA M12, MAMDC4, FAP, PRDX1 and ADAMTSL4, TNC, CLEC3B, AGR3, IL1RAP and PRDX1, AREG, PKD1, DCXR, IL1RAP and TNC, FGA, AGR3, SLAMF8, HEG1 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and DCXR, AREG, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and FGA, ADAM12, FGA, FAP, PRDX1 and NCS1, SERPINA1, AREG, IL1RAP, PLXDC2 and AGR3, PDIA4, CEACAM5, MEGF9, PE PD and ADAM12, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and NCS1, PDIA4, PEPD, DCXR, IL1RA P and ALCAM, SERPINA1, SLAMF8, PEPD, DCXR and MAMDC4, AREG, TNC, PKD1, MAMDC4 and FAP, PDIA4, PKD1, PEPD, DCXR and ADAMTSL4,PDIA4, MCAM, DCXR, ALCAM and CEACAM5, SERPINA1, CEACAM5, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ALCAM, PDIA 4, FGA, PKD1, DCXR and PEPD, SERPINA1, PDIA4, PKD1, DCXR and MAMDC4, AREG, ADAM12, HEG1, IL1RAP and PDIA4, AREG, FGA, HEG1, IL1RAP and NCS1, ADAM12, TNC, AGR3, IL1RAP and SERPINA1, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and PDIA4, AREG, ADAM12, PKD1, DCXR and PRDX1, ADAM12, TNC, AGR3, IL1RAP and ITIH3, CEACAM5, FGA, PEPD, HEG1 and TN C, PDIA4, ADAMTSL4, PKD1, DCXR and NCS1, FGA, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PKD1, PEPD, DCXR and ALCAM, PDIA4, TNC, IGFBP2, MCAM and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CEACAM5, AREG, CEACAM5, HEG1, IL1RAP and PRDX1, ADAM12, CEACAM5, FAP, PRDX1 and ITIH3, PDIA4, TBCB, PKD1, DCXR and ITIH3, AREG, TBCB, PKD1, DCXR and TN C, SERPINA1, SLAMF8, PEPD, DCXR and PDIA4, PDIA4, TNC, PEPD, FAP and CLEC3B, AREG, MAMDC4, IL1RAP, PLXDC2 and CLEC3B, PDIA4, TBCB, PKD1, DCXR and IL17RA, CEACAM5, FGA, PEPD, HEG1 and ADAM12, TNC, AGR3, MAMDC4, IL1RAP and PKD1, PDIA4, TNC, MCAM, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and MCAM, PDIA4, TNC, MAMDC4, CD55 and DCXR, AREG, PDIA4, DCXR, ALCAM and PEPD, AREG, TNC, MAMDC4, NCS1 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and IL17RA, ADAM12, FGA, MAMDC4, HEG1 and PEPD,AREG, FGA, HEG1, IL1RAP and DCXR, ADAM12, FGA, AGR3, IL1RAP and PEPD, PDIA4, CEACAM5, PKD1, DCXR and NCS1, CEACAM5, ADAMTSL4, HEG1, PRDX1 and IGFBP2, ADAM12, MAMDC4, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, PKD1, DCXR and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CLEC3B, SERPINA1, MAMDC4, IL1RAP, PL XDC2 and CEACAM5, AREG, ADAM12, HEG1, IL1RAP and DCXR, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and NCS1, ADAM12, PDIA4, CD55, FAP and AGR3, PDIA4, TBCB, PEPD, FAP and PRDX1, ADAM12, LRG1, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8, PDIA4, PKD1, DCXR, IL1RAP and FAP, AREG, FGA, PEPD, HE G1 and ADAMTSL4, SERPINA1, TNC, DCXR, PLXDC2 and PDIA4, SERPINA1, MEGF9, PRTN3, IL1RAP and AGR3, PDIA4, IGFBP2, PKD1, DCXR and IL17RA, SERPINA1, PDIA4, PKD1, DCXR and NC S1, PDIA4, TNC, MCAM, DCXR and NCS1, PDIA4, IGFBP2, PKD1, DCXR and ALCAM, PDIA4, PEPD, DCXR, IL1RAP and FAP, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1, PDIA4, FAP, DCXR, ALCAM and TBCB, AREG, CEACAM5, HEG1, IL1RAP and AGR3, PDIA4, TNC, ITIH3, PKD1 and TBCB, SERPINA1, AREG, IL1RAP, PLXDC2 and TNC, ADAM12, DCXR, IL1RAP, ALCAM and MAMDC4, PDIA4, TBCB, PEPD, FAP and AGR3, PDIA4, FGA, IGFBP2, PKD1 and ITIH3, C, PKD1, MAMDC4 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and SERPINA1,AREG, MA MDC4, IL1RAP, PLXDC2 and MCAM, SERPINA1, CEACAM5, CLEC3B, PRDX1 and AGR3, SERPINA 1, SLAMF8, PEPD, DCXR and ALCAM, PDIA4, PEPD, HEG1, FAP and CEACAM5, AREG, ADAM12, TNC, NCS1 and PRDX1, CEACAM5, FGA, PEPD, HEG1 and DCXR, AREG, TBCB, PKD1, DCX R and NCS1, SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and TBCB, ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4, SERPINA1, PKD1, SLAMF8, DCXR and PEPD, AREG, ADAM12, PDIA4, CD55 and AGR3, PDIA4, PKD1, DCXR, IL1RAP and ADAMTSL4, ADAM12, PDIA4, CD55, FAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and TBCB, SERPINA1, PDIA4, MAMD C4, PLXDC2 and PEPD, PDIA4, FAP, DCXR, ALCAM and NCS1, PDIA4, IL17RA, DCXR, ALCAM and NCS1, SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR, SERPINA1, CEACAM5, CLEC3B, PRD X1 and PDIA4, PDIA4, PEPD, DCXR, IL1RAP and PRDX1, SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD, ADAM12, PDIA4, DCXR, ALCAM and AGR3, CEACAM5, AGR3, SLAMF8, HEG1 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and ALCAM, AREG, TBCB, PKD1, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCAM, SERPINA1, AREG, PKD1, DCXR and ALCAM, AREG, ADAM12, PKD1, DCXR and ALCAM, AREG, PDIA4, DCXR, ALCAM and AGR3,ADAM12, PDIA4, CD55, FAP and PRDX1, SERPINA1, SLAMF8, DCXR, PLXDC2 and TNC, ADAM12, PDIA4, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXD C2 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and DCXR, SERPINA1, MEGF9, PRTN3, IL1RAP and TNC, CEACAM5, FGA, HEG1, PRDX1 and PEPD, PDIA4, PEPD, FAP, DCXR and TNC, PDIA 4, FGA, IGFBP2, PKD1 and TBCB, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAM12, AM12, HEG1, IL1RAP and ITIH3, ADAM12, PDIA4, DCXR, ALCAM and IGFBP2, AREG, PDIA4, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and MAMDC4, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and PRDX1, SERPINA1, PDIA4, MA MDC4, PLXDC2 and LRG1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and AGR3, SERPINA1, PDIA4, MAMDC4, PLXDC2 and TBCB, AREG, ADAM12, IL1RAP, PLXDC2 and DCXR, SERPINA1, AREG, FGA, HEG1 and PEPD, SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM, SERPINA1, PDIA4, PK D1, DCXR and AGR3, ADAM12, MAMDC4, FAP, PRDX1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and AGR3, PDIA4, ITIH3, PEPD, FAP and IL17RA, SERPINA1, AREG, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and ALCAM, CEACA M5, FGA, PEPD, HEG1 and IGFBP2, PDIA4, CEACAM5, PEPD, HEG1 and TBCB, PDIA4, FGA, PK D1, DCXR and MAMDC4,PDIA4, CEACAM5, PKD1, DCXR and PEPD, ADAM12, DCXR, IL1RAP, ALCAM and CEACAM5, SERPINA1, AREG, IL1RAP, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, ALCAM and CLEC3B, SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1, ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2, CEACAM5, TNC, FGA, HEG1 and MAMDC4, SERPINA1, TNC, DCXR, PLXDC2 and FAP, AREG, CEACAM5, FGA, HEG1 and MEGF9, FGA, AGR3, SLAMF8, HEG1 and FAP, SERPI NA1, SLAMF8, DCXR, PLXDC2 and ALCAM, SERPINA1, PKD1, SLAMF8, DCXR and PDIA4, ADA M12, TBCB, FAP, PRDX1 and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and ALCAM, PDIA4, MCAM, DCXR, ALCAM and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and IL17RA, SERPINA1, AREG, IL1RA P, PLXDC2 and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and ALCAM, PDIA4, TBCB, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and PEPD, PDIA4, CEACAM5, PKD1, DCXR and TNC, SERPIN A1, SLAMF8, PEPD, DCXR and ADAMTSL4, AREG, TNC, PKD1, MAMDC4 and DCXR, PDIA4, CE ACAM5, DCXR, ALCAM and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and TNC, AREG, ADAM 12, IL1RAP, PLXDC2 and ALCAM, AREG, PKD1, DCXR, IL1RAP and TBCB, PDIA4, TNC, MAMD C4, CD55 and ADAM12, PDIA4, PKD1, PRTN3, PEPD and TBCB, ADAM12, FGA, MAMDC4, HEG1 and FAP, PDIA4, PKD1, PRTN3, PEPD and AGR3, PDIA4, CLEC3B, PKD1, DCXR and MAMDC4, SE RPINA1, HEG1, IL1RAP, PLXDC2 and PEPD,ADAM12, PDIA4, PKD1, DCXR and NCS1, FGA, SLA MF8, PEPD, HEG1 and ALCAM, SERPINA1, AREG, IL1RAP, PLXDC2 and TBCB, PDIA4, TBCB, PKD1, DCXR and LRG1, PDIA4, PEPD, DCXR, IL1RAP and NCS1, SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1, ADAM12, FGA, AGR3, IL1RAP and DCXR, AREG, ADAM12, PKD1, DCXR and IL17RA, ADAM12, CEACAM5, DCXR, IL1RAP and FGA, TNC, CLEC3B, AGR3, IL1RAP and FAP, FGA, CLEC3B, MAMDC4, HEG1 and AGR3, AREG, MA MDC4, IL1RAP, PLXDC2 and DCXR, CEACAM5, FGA, PEPD, HEG1 and TBCB, AREG, ADAM12, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ITIH3, AREG, PDIA4, CEACAM5, HEG1 and PEPD, PDIA4, ITIH3, PKD1, PEPD and DCXR, CEACAM5, AGR3, HEG1, PRDX1 and SERPINA1, ADAM12, AGR3, MAMDC4, IL1RAP and DCXR, AREG, TBCB, PKD1, DCXR and ADAMTSL4, SERPINA1, PKD1, SLAMF8, DCXR and ALCAM, AD AM12, FGA, SLAMF8, NCS1 and IL17RA, PDIA4, PKD1, PEPD, DCXR and MCAM, CEACAM5, AGR3, HEG1, PRDX1 and CLEC3B, AREG, TBCB, PKD1, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and IL17RA, PDIA4, SLAMF8, MCAM, DCXR and PRDX1, FGA, AGR3, SLAMF8, HEG1 and PDI A4, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL4, PDIA4, FAP, DCXR, ALCAM and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and CLEC3B, PDI A4, ADAMTSL4, PKD1, DCXR and SERPINA1,PDIA4, PKD1, DCXR, IL1RAP and IL17RA, ADAM12, TNC, FAP, PRDX1 and NCS1, SERPINA1, SLAMF8, DCXR, PLXDC2 and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5, ADAM12, CEACAM5, DCXR, IL1RAP and LRG1, ADAM12, FGA, SLAMF8, NCS1 and SERPINA1, ADAM12, PDIA4, CD55, FAP and IL17RA, SERPINA1, PEPD, IL1RAP, PLXDC2 and MCAM , PDIA4, PEPD, DCXR, IL1RAP and MAMDC4, PDIA4, PEPD, DCXR, IL1RAP and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and LRG1, AREG, PDIA4, CEACAM5, HEG1 and NCS1, PDIA4, TNC, MCAM, DCXR and PRDX1, PDIA4, CEACAM5, PEPD, HEG1 and PRDX1, SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2, PDIA4, ITIH3, PEPD, FAP and ALCAM, CEAC AM5, AGR3, SLAMF8, HEG1 and LRG1, PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4, SERPI NA1, PEPD, IL1RAP, PLXDC2 and DCXR, FGA, SLAMF8, PEPD, HEG1 and CLEC3B, ADAM12, DCXR, IL1RAP, ALCAM and ITIH3, AREG, ADAM12, PKD1, DCXR and MCAM, PDIA4, SLAMF8, MCAM, DCXR and FAP, ADAM12, TNC, AGR3, IL1RAP and TBCB, PDIA4, SLAMF8, MCAM, DCXR and SERPINA1, PDIA4, FGA, PKD1, DCXR and TBCB, PDIA4, FGA, PEPD, HEG1 and TNC, CEACAM M5, ADAMTSL4, HEG1, PRDX1 and MAMDC4, ADAM12, MAMDC4, FAP, PRDX1 and CLEC3B, PDIA4, PKD1, PRTN3, PEPD and NCS1, PDIA4, TBCB, PKD1, DCXR and ADAM12, ADAM12, CEAC AM5, FGA, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PDIA4,CEACAM5, FGA, HEG1, PRDX1 and SERPINA1, CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4, PDIA4, TNC, MAMDC4, CD55 and NCS1, ADAM12, PEPD, FAP, PRDX1 and PDIA4, FGA, SLAMF8, PEPD, HEG1 and TNC, AREG, PDIA4, PKD1, DCXR and CEACAM5, SERPINA1, AREG, PKD1, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and TNC, ADAM12, FGA, AGR3, IL1RAP and CLEC3B, PDIA4, IGFBP2, DCXR, ALCAM and TNC, AREG, ADAM12, HEG1, IL1RAP and PRDX1, EGF9, PEPD and NCS1, ADAM12, PDIA4, DCXR, ALCAM and IL17RA, SERPINA1, ADAM12, FAP, PRDX1 and TBCB, PDIA4, CEACAM5, PKD1, DCXR and FGA, AREG, ADAM12, IL1RAP, PLXDC2 and PDIA4, PDIA4, FGA, PKD1, DCXR and ASPN, CEACAM5, ADAMTSL4, HEG1, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PDIA4, AREG, TNC, MAMDC4, NCS1 and ITIH3, SERPINA1, AREG, FGA, HEG1 and PDIA4, PDIA4, CEACAM5, PEPD, HEG1 and NCS1, CEACAM5, SLAMF8, PEP D, HEG1 and IGFBP2, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF 8, NCS1 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and PEPD, PDIA4, PEPD, FAP, DCXR and NCS1, TNC, CLEC3B, AGR3, IL1RAP and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and PDIA4, PDIA4, PKD1, PRTN3, PEPD and PRDX1, SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8, ADAM12, FGA, AGR3, IL1RAP and PRDX1, PDIA4, ITIH3, PEPD, FAP and CEACAM5,CEACAM5, FGA, HE G1, PRDX1 and IL17RA, ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and IGFBP2, ADAM12, PDIA4, CD55, FAP and MAMDC4, AREG, ADAM12, PKD1, DCXR and CLEC3B, SERPINA1, PKD1, SLAMF8, DCXR and LRG1, CEACAM5, SLAMF8, PEPD, HEG1 and TNC, AREG, TNC, MAMDC4, NCS1 and MCAM, TNC, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, LRG1, FAP, PRDX1 and DCXR, PDIA4, ADAMTSL4, PKD1, DCXR and AGR3, AREG, TNC, PK D1, MAMDC4 and IGFBP2, ADAM12, TBCB, FAP, PRDX1 and DCXR, AREG, PDIA4, PKD1, DCXR and ALCAM, FGA, TBCB, MAMDC4, HEG1 and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and PDI A4, SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM, PDIA4, ITIH3, PKD1, PEPD and IGFBP2, PDI A4, PEPD, DCXR, IL1RAP and ADAMTSL4, AREG, MAMDC4, IL1RAP, PLXDC2 and ALCAM, ADAM12, DCXR, IL1RAP, ALCAM and ADAMTSL4, PDIA4, CEACAM5, DCXR, ALCAM and NCS1, AD AM12, CEACAM5, DCXR, IL1RAP and PRDX1, CEACAM5, SLAMF8, HEG1, DCXR and AGR3, SER PINA1, PEPD, IL1RAP, PLXDC2 and ITIH3, SERPINA1, HEG1, IL1RAP, PLXDC2 and ALCAM, ADA M12, FGA, FAP, PRDX1 and PDIA4, PDIA4, TNC, MAMDC4, CD55 and TBCB, AREG, FGA, PEPD, HEG1 and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and LRG1, ADAM12, PDIA4, DCXR, ALCAM and MCAM, CEACAM5, SLAMF8, HEG1, DCXR and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and MCAM,ADAM12, TNC, FAP, PRDX1 and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and MAMD C4, AREG, PDIA4, DCXR, ALCAM and ADAM12, AREG, TBCB, PKD1, DCXR and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and PEPD, AREG, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, TBCB, PEPD, FAP and ADAMTSL4, SERPINA1, CLEC3B, IL1RAP, PLXDC2 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and NCS1, AREG, MAMDC4, IL1RA P, PLXDC2 and PDIA4, SERPINA1, TNC, DCXR, PLXDC2 and AGR3, ADAM12, CLEC3B, AGR3, IL1RAP and CEACAM5, PDIA4, FGA, PKD1, DCXR and ADAMTSL4, PDIA4, ITIH3, PKD1, PEPD and FAP, PDIA4, FGA, PKD1, DCXR and LRG1, PDIA4, CEACAM5, MEGF9, PEPD and ALCAM, ADAM12, FGA, MAMDC4, HEG1 and TNC, CEACAM5, FG A, HEG1, PRDX1 and PDIA4, ADAM12, CEACAM5, FAP, PRDX1 and ADAMTSL4, PDIA4, TNC, MCAM, DCXR and CLEC3B, PDIA4, TNC, MAMDC4, CD55 and FGA, AREG, FGA, HEG1, IL1RAP and FAP, CEACAM5, FGA, PEPD, HEG1 and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3, PDIA4, PKD1, PRTN3, PEPD and MAMDC4, PDI A4, TNC, PEPD, FAP and ALCAM, AREG, FGA, PEPD, HEG1 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and ASPN, SERPINA1, CEACAM5, CLEC3B, PRDX1 and MAMDC4, ADAM12, FGA, FAP, PRDX1 and IL17RA, PDIA4, FGA, PKD1, DCXR and NCS1, AREG, MAMDC4, IL1RAP, PLXDC 2 and TNC, PDIA4, DCXR, IL1RAP, ALCAM and MAMDC4,SERPINA1, CEACAM5, FGA, HEG1 and AGR3, PDIA4, SLAMF8, MCAM, DCXR and AGR3, AREG, ADAM12, PKD1, DCXR and SERPINA1, PDIA4, IGFBP2, CD55, MCAM and DCXR, PDIA4, FGA, PKD1, DCXR and ALCAM, PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4, PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4, PDIA4, IGFBP2, PKD1, DCXR and LRG1, AREG, ADAM12, PKD1, DC XR and CEACAM5, ADAM12, DCXR, IL1RAP, ALCAM and PRDX1, ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4, PDIA4, PEPD, FAP, DCXR and AGR3, TNC, AGR3, MAMDC4, IL1RAP and TB CB, ADAM12, PDIA4, DCXR, ALCAM and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1 and NCS1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and ALCAM, AREG, PDIA4, CEACAM5, HEG1 and PRDX1, ADAM12, TBCB, FAP, PRDX1 and CLEC3B, PDIA4, PEPD, HEG1, FAP and PRDX1, TNC, AGR3, MAMDC4, IL1RAP and PEPD, ADAM12, CEACAM5, FGA, HEG1 and PDIA4, PDIA4, IGFBP2, DCX R, ALCAM and TBCB, CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA, PDIA4, FGA, PEPD, HEG1 and TBCB, ADAM12, FGA, SLAMF8, NCS1 and ITIH3, AREG, TBCB, PKD1, DCXR and PDIA4, PDIA4, PKD1, PRTN3, PEPD and DCXR, PDIA4, PEPD, FAP, DCXR and CLEC3B, PDIA4, SLAMF8, MCAM, DCXR and MAMDC4, AREG, PDIA4, DCXR, ALCAM and TBCB, SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3, SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4,ADAM12, PDIA4, DCXR, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1 and MAMDC4, AREG, PKD1, DCXR, IL1RAP and FA P, ADAM12, PDIA4, PKD1, DCXR and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and AGR3, PDIA4, TNC, ITIH3, PKD1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and IL17RA, FGA, TBCB, MA MDC4, HEG1 and AGR3, PDIA4, TNC, PEPD, FAP and AGR3, SERPINA1, AREG, PKD1, DCXR and ADAMTSL4, FGA, AGR3, SLAMF8, HEG1 and SERPINA1,PDIA4TBCB, PKD1, DCXR and PEPD, PDIA4, TBCB, PEPD, FAP and DCXR, SERPINA1, PDIA4, PKD1, DCXR and PEPD, ADAM12, TNC, AG R3, IL1RAP and MAMDC4, ADAM12, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, TBCB, FAP, PR DX1 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and ADAM12, TNC, CLEC3B, AGR3, IL1RAP and MAMDC4, CEACAM5, ADAMTSL4, HEG1, PRDX1 and AGR3, PDIA4, DCXR, IL1RAP, ALCAM and PEPD, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PEPD, CEACAM5, AGR3, SLAMF8, HEG1 and FGA, PDIA4, TBCB, PKD1, DCXR and CEACAM5, PDIA4, TN C, PEPD, FAP and TBCB, ADAM12, PDIA4, PKD1, DCXR and TBCB, ADAM12, PEPD, FAP, PRDX1 and DCXR, PDIA4, TNC, PEPD, FAP and DCXR, PDIA4, PKD1, PEPD, DCXR and CEACAM5, AREG, MAMDC4, IL1RAP, PLXDC2 and SERPINA1, CEACAM5, SLAMF8, HEG1, DCXR and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and ADAM12, ADAM12, MA MDC4, FAP, PRDX1 and PEPD, ADAM12, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, CEACAM5, PEPD, HEG1 and FAP, or CEACAM5, TNC, FGA, HEG1 and PEPD (i.e., 699 5-marker combinations in Table 7).

[0037] Preferably, the 5 markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC, PDIA4, PKD1, PEPD, DCXR and TBCB, CEACAM5, TNC, FGA, HEG1 and DCXR, PDIA4, PEPD, DCXR, IL1RAP and TNC, CEACAM5, FGA, PEPD, HEG1 and SERPINA1, ADAM12, PEPD, FAP, PRDX1 and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC, PDIA4, PRTN3, PEPD, FAP and DCXR, SERPINA1, ADAM12, IL1RAP, PLXDC2 and TBCB, ADAM12, PDIA4, DCXR, ALCAM and NCS1. R3, MAMDC4, IL1RAP and LRG1, CEACAM5, ADAMTSL4, HEG1, PRDX1 and PDIA4, PDIA4, PKD 1, PEPD, DCXR and MAMDC4, SERPINA1, AREG, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PEPD, FAP, DCXR and MCAM, TNC, AGR3, MAMDC4, IL1RAP and CLEC3B, ADAM12, AGR3, MAMDC4, IL1RAP and SERPINA1, AREG, ADAM12, TNC, NCS1 and PEPD, PDIA4, PEPD, HEG1, FAP and TNC, PDIA4, PKD1, PEPD, DCXR and FAP, SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4, PDIA4, PEPD, FAP, DCXR and TBCB, SERPINA1, CEACAM5, FGA, HEG1 and MAMDC4, PDIA4, PKD1, PRTN3, PEPD and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and ADAMTSL4, ADAM12, MAMD C4, FAP, PRDX1 and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and NCS1, PDIA4, PEPD, HEG1, FAP and DCXR, CEACAM5, SLAMF8, PEPD, HEG1 and ADAM12, AREG, PDIA4, DCXR, ALCAM and MAMDC4, PDIA4, PKD1, DCXR, IL1RAP and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and MAM DC4, PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4,ADAM12, FGA, MAMDC4, HEG1 and TBC B, AREG, PDIA4, PKD1, DCXR and MAMDC4, AREG, PDIA4, PKD1, DCXR and TNC, CEACAM5, AGR3, HEG1, PRDX1 and SLAMF8, PDIA4, PKD1, PEPD, DCXR and SERPINA1, ADAM12, DCXR, IL1RAP, ALCAM and TNC, CEACAM5, AGR3, SLAMF8, HEG1 and TBCB, PDIA4, ADAMTSL4, PK D1, DCXR and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and DCXR, PDIA4, FAP, DCXR, ALCAM and PEPD, TNC, AGR3, MAMDC4, IL1RAP and ALCAM, AREG, PKD1, SLAMF8, DCXR and IGF BP2, TNC, AGR3, MAMDC4, IL1RAP and MCAM, ADAM12, AGR3, MAMDC4, IL1RAP and SLAMF 8, ADAM12, PDIA4, DCXR, ALCAM and CLEC3B, PDIA4, IL17RA, DCXR, ALCAM and AGR3, PD IA4, MCAM, DCXR, ALCAM and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and DCXR, SERPIN A1, HEG1, IL1RAP, PLXDC2 and DCXR, PDIA4, TNC, PEPD, FAP and MCAM, AREG, TBCB, PK D1, DCXR and CEACAM5, SERPINA1, PDIA4, PKD1, DCXR and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and TNC, ADAM12, FGA, MAMDC4, HE G1, ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and TNC, AREG, MAMDC4, IL1RAP, PLXDC 2 and FAP, TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4, PDIA4, PKD1, PEPD, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and MAMDC4, PDIA4, IGFBP2, PKD1, DCXR and MAMDC4, CEACAM 5. AGR3, HEG1, PRDX1 and MAMDC4, FGA, SLAMF8, PEPD, HEG1 and SERPINA1,AREG, ADAM12, PDIA4, CD55 and DCXR, PDIA4, PEPD, FAP, DCXR and SERPINA1, ADAM12, MAMDC4, FAP, PRDX1 and TBCB, ADAM12, FGA, AGR3, IL1RAP and CEACAM5, PDIA4, PKD1, DCXR, IL1RAP and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MCAM, SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and MCAM, PDIA4, CEACAM5, DCXR, ALCAM and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and TB CB, ADAM12, PEPD, FAP, PRDX1 and IL17RA, AREG, ADAM12, TNC, NCS1 and DCXR, PDIA4, CLEC3B, PKD1, DCXR and PEPD, AREG, FGA, HEG1, IL1RAP and PDIA4, SERPINA1, PKD1, SLA MF8, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and TBCB, ADAM12, FAP, PRDX1, DCXR and PEPD, AREG, PDIA4, PKD1, DCXR and NCS1, PDIA4, PEPD, DCXR, IL1RAP and MCAM, AREG, TNC, MAMDC4, NCS1 and TBCB, PDIA4, PKD1, PRTN3, PEPD and ADAMTSL4, ADAM12, AGR3, MAMDC4, IL1RAP and CEACAM5, SERPINA1, AREG, FGA, HEG1 and MAMDC4, PDIA4, TBCB, PKD1, DCXR and ALCAM, PDIA4, TBCB, PEPD, FAP and TNC, CEACAM5, AGR3, HEG1, PRDX1 and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and LRG1, ADAM12, FGA, MAMDC4, HEG1 and SERPINA1, FGA, AGR3, SLAMF8, HEG1 and TNC, AREG, PDIA4, CEACAM5, HEG1 and MAMDC4, ADAM12, CEACAM5, FGA, HEG1 and IL17RA, AREG, MAMDC4, IL1RAP, PLXDC2 and TBCB, SE RPINA1, CEACAM5, FGA, HEG1 and PDIA4,ADAM12, AGR3, MAMDC4, IL1RAP and FAP, ADAM 12, PDIA4, PKD1, DCXR and PEPD, ADAM12, AGR3, MAMDC4, IL1RAP and MCAM, AREG, FGA, PEPD, HEG1 and TBCB, PDIA4, TNC, MCAM, DCXR and PEPD, ADAM12, FGA, AGR3, IL1RAP and MAMDC4, PDIA4, CEACAM5, DCXR, ALCAM and PRDX1, SERPINA1, AREG, FGA, HEG1 and IL17RA, AREG, TNC, PKD1, MAMDC4 and NCS1, TNC, AGR3, MAMDC4, IL1RAP and DCXR, TNC, AGR3, MAMDC4, IL1RAP and FAP, AREG, CEACAM5, FGA, HEG1 and PRDX1, CEACAM5, SLAM F8, PEPD, HEG1 and LRG1, PDIA4, PEPD, FAP, DCXR and CEACAM5, FGA, AGR3, SLAMF8, HE G1 and TBCB, AREG, FGA, PEPD, HEG1 and DCXR, PDIA4, PKD1, PEPD, DCXR and LRG1, CEAC AM5, AGR3, SLAMF8, HEG1 and TNC, PDIA4, PEPD, FAP, DCXR and SLAMF8, ADAM12, FGA, MAMDC4, HEG1 and NCS1, AREG, FGA, PEPD, HEG1 and NCS1, ADAM12, FAP, PRDX1, DCXR and ALCAM, ADAM12, PEPD, FAP, PRDX1 and MCAM, ADAM12, CEACAM5, FAP, PRDX1 and PEP D, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PEPD, SERPINA1, SLAMF8, DCXR, PLXDC2 and MAMDC4, SERPINA1, PDIA4, PKD1, DCXR and ALCAM, AREG, PKD1, DCXR, IL1RAP and PDIA4, CEACAM5, AGR3, SLAMF8, HEG1 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP and SERPINA1, PDIA4, DCXR, IL1RAP, ALCAM and MCAM, PDIA4, PEPD, DCXR, IL1RAP and CEACAM5, PDIA4, TBCB, PEPD, FAP and LRG1,ADAM12, AGR3, MAM DC4, IL1RAP and ITIH3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ALCAM, ADAM12, FGA, SLAMF 8, NCS1 and ALCAM, ADAM12, TNC, AGR3, IL1RAP and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and MAMDC4, AREG, TNC, PKD1, MAMDC4 and PEPD, SERPINA1, CEACAM5, HEG1, IL1RAP and DC XR, PDIA4, ITIH3, PKD1, PEPD and MAMDC4, AREG, FGA, PEPD, HEG1 and MCAM, PDIA4, PR TN3, PEPD, FAP and LRG1, TNC, AGR3, MAMDC4, IL1RAP and PDIA4, SERPINA1, ADAM12, FA P, PRDX1 and DCXR, PDIA4, TBCB, PEPD, FAP and CEACAM5, ADAM12, FGA, MAMDC4, HEG1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and DCXR, SERPINA1, SLAMF8, PEPD, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and IL17RA, ADAM12, FGA, FAP, PRDX1 and AGR3, TNC, AGR 3, MAMDC4, IL1RAP and LRG1, PDIA4, TBCB, PKD1, DCXR and NCS1, SERPINA1, AREG, PKD1, DCXR and PDIA4, AREG, ADAM12, PDIA4, CD55 and CLEC3B, PDIA4, TNC, PEPD, FAP and CEAC AM5, ADAM12, LRG1, FAP, PRDX1 and IL17RA, FGA, TBCB, MAMDC4, HEG1 and TNC, PDIA4, CEACAM5, PEPD, HEG1 and ADAM12, PDIA4, TNC, ITIH3, PKD1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and MCAM, PDIA4, DCXR, IL1RAP, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1 and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and PEPD, PDIA4, PEPD, DCXR, IL1RAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and PEPD, ADAM12, DCXR, IL1RAP, ALCAM and NCS1,PDIA4, FAP, DCXR, ALCAM and PRDX1, SERPINA1, TNC, DCXR, PLXDC2 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and AGR3, PDIA4, TBCB, PEPD, FAP and NCS1, ADAM12, FGA, AGR 3, IL1RAP and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and FAP, PDIA4, FGA, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, SLAMF8, NCS1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and MAM DC4, AREG, ADAM12, FGA, HEG1 and ALCAM, SE RPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB, FGA, AGR3, SLAMF8, HEG1 and NCS1, PDIA4, PEPD, HEG1, FAP and SERPINA1, SERPINA1, TNC, DCXR, PLXDC2 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MCAM, SERPINA1, SLAMF8, DCXR, PLXDC2 and FAP, CEACAM5, ADAMTSL4, SL AMF8, HEG1 and MAMDC4, PDIA4, IGFBP2, DCXR, ALCAM and IL17RA, ADAM12, TNC, FAP, PRDX1 and PEPD, PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA, CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12, SERPINA1, SLAMF8, PEPD, DCXR and NCS1, PDIA4, ADAMTSL4, PKD1, DCXR and FAP, FAP, AGR3, SLAMF8, HEG1 and DCXR, PDIA 4, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and NCS1, CEACAM5, TNC, FGA, HEG1 and NCS1, ADAM12, CLEC3B, AGR3, IL1RAP and TBCB, ADAM12, PEPD, FAP, PRDX 1 and SERPINA1, ADAM12, FGA, AGR3, IL1RAP and IL17RA, SERPINA1, PDIA4, MAMDC4, PLXD C2 and NCS1,PDIA4, DCXR, IL1RAP, ALCAM and FAP, SERPINA1, AREG, PKD1, DCXR and CEAC AM5, PDIA4, FAP, DCXR, ALCAM and ITIH3, CEACAM5, AGR3, HEG1, PRDX1 and PDIA4, SERP INA1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4, IL17RA, DCXR, ALCAM and MAMDC4, PDI A4, FGA, PEPD, HEG1 and DCXR, ADAM12, LRG1, FAP, PRDX1 and ALCAM, FGA, AGR3, SLA MF8, HEG1 and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and IGFBP2, SERPINA1, TBCB, SL AMF8, PLXDC2 and MCAM, PDIA4, PEPD, FAP, DCXR and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and MCAM, SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5, AREG, PKD1, DCXR, IL1RAP and NCS1, PDIA4, CEACAM5, PKD1, DCXR and TBCB, SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP, PDIA4, FGA, IGFBP2, PKD1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1 and PKD1, PDI A4, PEPD, HEG1, FAP and MAMDC4, PDIA4, IL17RA, DCXR, ALCAM and TNC, AREG, PKD1, DCXR, IL1RAP and MAMDC4, AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3, ADAM12, AGR3, MA MDC4, IL1RAP and PRDX1, SERPINA1, PDIA4, CEACAM5, HEG1 and NCS1, ADAM12, CEACAM5, FAP, PRDX1, DCXR, AREG, PKD1, DCXR, IL1RAP and ALCAM, PDIA4, FAP, DCXR, ALCAM and MAMDC4, PDIA4, PEPD, HEG1, FAP and LRG1, ADAM12, TBCB, FAP, PRDX1 and TNC, CEAC AM5, SLAMF8, HEG1, DCXR and NCS1, CEACAM5, FGA, HEG1, PRDX1 and ALCAM, PDIA4, TN C, MCAM, DCXR and MAMDC4,FGA, CLEC3B, MAMDC4, HEG1 and PDIA4, AREG, TNC, PKD1, MAMDC4 and TBCB, AREG, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, MCAM, DCXR, ALC AM and PRDX1, ADAM12, FAP, PRDX1, DCXR and IL17RA, SERPINA1, CEACAM5, CLEC3B, PRD X1 and ALCAM, CEACAM5, FGA, PEPD, HEG1 and AGR3, PDIA4, CEACAM5, PEPD, HEG1 and SLAMF8, PDIA4, TBCB, PEPD, FAP and ALCAM, PDIA4, PEPD, FAP, DCXR and LRG1, AREG, AD AM12, PKD1, DCXR and NCS1, CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2, SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD, ADAM12, MAMDC4, FAP, PRDX1 and IL17RA, ADAM12, AGR3, MA MDC4, IL1RAP and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD, AREG, PDIA4, PKD1, DCXR and ADAMTSL4, CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B, AREG, ADAM12, FGA, HEG1 and AGR3, AREG, FGA, HEG1, IL1RAP and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and PEP D, AREG, PKD1, DCXR, IL1RAP and MCAM, PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4, AREG, ADAM12, PDIA4, CD55 and NCS1, ADAM12, FGA, AGR3, IL1RAP and TNC, SERPINA1, PEP D, IL1RAP, PLXDC2 and LRG1, AREG, PKD1, DCXR, IL1RAP and PEPD, TNC, AGR3, MAMDC4, IL1RAP and CEACAM5, AREG, TNC, MAMDC4, NCS1 and DCXR, AREG, PKD1, SLAMF8, DCXR and NCS1, AREG, TNC, MAMDC4, NCS1 and ALCAM, PDIA4, PRTN3, PEPD, FAP and ADAMTSL4, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB,CEACAM5, AGR3, SLAMF8, HEG1 and SERPI NA1, PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B, ADAM12, FGA, FAP, PRDX1 and PEPD, TNC, CLEC3B, AGR3, IL1RAP and ADAMTSL4, CEACAM5, AGR3, SLAMF8, HEG1 and ALCAM, ADAM12, CEACAM5, FAP, PRDX1 and PDIA4, AREG, PDIA4, DCXR, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and TNC, SERPINA1, PEPD, IL1RA P, PLXDC2 and MAMDC4, AREG, PKD1, SLAMF8, DCXR and TBCB, FGA, AGR3, SLAMF8, HEG1 and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4, ADAM12, FGA, AGR3, IL1RAP and ALCAM, PDIA4, PRTN3, PEPD, FAP and SERPINA1, ADAM12, CLEC3B, AGR3, IL1RAP and NCS1, SERPINA1, PKD1, SLAMF8, DCXR and TBCB, ADA M12, MAMDC4, FAP, PRDX1 and ADAMTSL4, TNC, CLEC3B, AGR3, IL1RAP and PRDX1, AREG, PKD1, DCXR, IL1RAP and TNC, FGA, AGR3, SLAMF8, HEG1 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and DCXR, AREG, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and FGA, ADAM12, FGA, FAP, PRDX1 and NCS1, SERPINA1, AREG, IL1RAP, PLXDC2 and AGR3, PDIA4, CEACAM5, MEGF9, PE PD and ADAM12, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and NCS1, PDIA4, PEPD, DCXR, IL1RA P and ALCAM, SERPINA1, SLAMF8, PEPD, DCXR and MAMDC4, AREG, TNC, PKD1, MAMDC4 and FAP, PDIA4, PKD1, PEPD, DCXR and ADAMTSL4,PDIA4, MCAM, DCXR, ALCAM and CEACAM5, SERPINA1, CEACAM5, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ALCAM, PDIA 4, FGA, PKD1, DCXR and PEPD, SERPINA1, PDIA4, PKD1, DCXR and MAMDC4, AREG, ADAM12, HEG1, IL1RAP and PDIA4, AREG, FGA, HEG1, IL1RAP and NCS1, ADAM12, TNC, AGR3, IL1RAP and SERPINA1, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and PDIA4, AREG, ADAM12, PKD1, DCXR and PRDX1, ADAM12, TNC, AGR3, IL1RAP and ITIH3, CEACAM5, FGA, PEPD, HEG1 and TN C, PDIA4, ADAMTSL4, PKD1, DCXR and NCS1, FGA, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PKD1, PEPD, DCXR and ALCAM, PDIA4, TNC, IGFBP2, MCAM and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CEACAM5, AREG, CEACAM5, HEG1, IL1RAP and PRDX1, ADAM12, CEACAM5, FAP, PRDX1 and ITIH3, PDIA4, TBCB, PKD1, DCXR and ITIH3, AREG, TBCB, PKD1, DCXR and TN C, SERPINA1, SLAMF8, PEPD, DCXR and PDIA4, PDIA4, TNC, PEPD, FAP and CLEC3B, AREG, MAMDC4, IL1RAP, PLXDC2 and CLEC3B, PDIA4, TBCB, PKD1, DCXR and IL17RA, CEACAM5, FGA, PEPD, HEG1 and ADAM12, TNC, AGR3, MAMDC4, IL1RAP and PKD1, PDIA4, TNC, MCAM, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and MCAM, PDIA4, TNC, MAMDC4, CD55 and DCXR, AREG, PDIA4, DCXR, ALCAM and PEPD, AREG, TNC, MAMDC4, NCS1 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and IL17RA, ADAM12, FGA, MAMDC4, HEG1 and PEPD,AREG, FGA, HEG1, IL1RAP and DCXR, ADAM12, FGA, AGR3, IL1RAP and PEPD, PDIA4, CEACAM5, PKD1, DCXR and NCS1, CEACAM5, ADAMTSL4, HEG1, PRDX1 and IGFBP2, ADAM12, MAMDC4, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, PKD1, DCXR and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CLEC3B, SERPINA1, MAMDC4, IL1RAP, PL XDC2 and CEACAM5, AREG, ADAM12, HEG1, IL1RAP and DCXR, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and NCS1, ADAM12, PDIA4, CD55, FAP and AGR3, PDIA4, TBCB, PEPD, FAP and PRDX1, ADAM12, LRG1, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8, PDIA4, PKD1, DCXR, IL1RAP and FAP, AREG, FGA, PEPD, HE G1 and ADAMTSL4, SERPINA1, TNC, DCXR, PLXDC2 and PDIA4, SERPINA1, MEGF9, PRTN3, IL1RAP and AGR3, PDIA4, IGFBP2, PKD1, DCXR and IL17RA, SERPINA1, PDIA4, PKD1, DCXR and NC S1, PDIA4, TNC, MCAM, DCXR and NCS1, PDIA4, IGFBP2, PKD1, DCXR and ALCAM, PDIA4, PEPD, DCXR, IL1RAP and FAP, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1, PDIA4, FAP, DCXR, ALCAM and TBCB, AREG, CEACAM5, HEG1, IL1RAP and AGR3, PDIA4, TNC, ITIH3, PKD1 and TBCB, SERPINA1, AREG, IL1RAP, PLXDC2 and TNC, ADAM12, DCXR, IL1RAP, ALCAM and MAMDC4, PDIA4, TBCB, PEPD, FAP and AGR3, PDIA4, FGA, IGFBP2, PKD1 and ITIH3, C, PKD1, MAMDC4 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and SERPINA1,AREG, MA MDC4, IL1RAP, PLXDC2 and MCAM, SERPINA1, CEACAM5, CLEC3B, PRDX1 and AGR3, SERPINA 1, SLAMF8, PEPD, DCXR and ALCAM, PDIA4, PEPD, HEG1, FAP and CEACAM5, AREG, ADAM12, TNC, NCS1 and PRDX1, CEACAM5, FGA, PEPD, HEG1 and DCXR, AREG, TBCB, PKD1, DCX R and NCS1, SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and TBCB, ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4, SERPINA1, PKD1, SLAMF8, DCXR and PEPD, AREG, ADAM12, PDIA4, CD55 and AGR3, PDIA4, PKD1, DCXR, IL1RAP and ADAMTSL4, ADAM12, PDIA4, CD55, FAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and TBCB, SERPINA1, PDIA4, MAMD C4, PLXDC2 and PEPD, PDIA4, FAP, DCXR, ALCAM and NCS1, PDIA4, IL17RA, DCXR, ALCAM and NCS1, SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR, SERPINA1, CEACAM5, CLEC3B, PRD X1 and PDIA4, PDIA4, PEPD, DCXR, IL1RAP and PRDX1, SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD, ADAM12, PDIA4, DCXR, ALCAM and AGR3, CEACAM5, AGR3, SLAMF8, HEG1 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and ALCAM, AREG, TBCB, PKD1, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCAM, SERPINA1, AREG, PKD1, DCXR and ALCAM, AREG, ADAM12, PKD1, DCXR and ALCAM, AREG, PDIA4, DCXR, ALCAM and AGR3,ADAM12, PDIA4, CD55, FAP and PRDX1, SERPINA1, SLAMF8, DCXR, PLXDC2 and TNC, ADAM12, PDIA4, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXD C2 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and DCXR, SERPINA1, MEGF9, PRTN3, IL1RAP and TNC, CEACAM5, FGA, HEG1, PRDX1 and PEPD, PDIA4, PEPD, FAP, DCXR and TNC, PDIA 4, FGA, IGFBP2, PKD1 and TBCB, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAM12, AM12, HEG1, IL1RAP and ITIH3, ADAM12, PDIA4, DCXR, ALCAM and IGFBP2, AREG, PDIA4, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and MAMDC4, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and PRDX1, SERPINA1, PDIA4, MA MDC4, PLXDC2 and LRG1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and AGR3, SERPINA1, PDIA4, MAMDC4, PLXDC2 and TBCB, AREG, ADAM12, IL1RAP, PLXDC2 and DCXR, SERPINA1, AREG, FGA, HEG1 and PEPD, SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM, SERPINA1, PDIA4, PK D1, DCXR and AGR3, ADAM12, MAMDC4, FAP, PRDX1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and AGR3, PDIA4, ITIH3, PEPD, FAP and IL17RA, SERPINA1, AREG, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and ALCAM, CEACA M5, FGA, PEPD, HEG1 and IGFBP2, PDIA4, CEACAM5, PEPD, HEG1 and TBCB, PDIA4, FGA, PK D1, DCXR and MAMDC4,PDIA4, CEACAM5, PKD1, DCXR and PEPD, ADAM12, DCXR, IL1RAP, ALCAM and CEACAM5, SERPINA1, AREG, IL1RAP, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, ALCAM and CLEC3B, SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1, ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2, CEACAM5, TNC, FGA, HEG1 and MAMDC4, SERPINA1, TNC, DCXR, PLXDC2 and FAP, AREG, CEACAM5, FGA, HEG1 and MEGF9, FGA, AGR3, SLAMF8, HEG1 and FAP, SERPI NA1, SLAMF8, DCXR, PLXDC2 and ALCAM, SERPINA1, PKD1, SLAMF8, DCXR and PDIA4, ADA M12, TBCB, FAP, PRDX1 and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and ALCAM, PDIA4, MCAM, DCXR, ALCAM and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and IL17RA, SERPINA1, AREG, IL1RA P, PLXDC2 and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and ALCAM, PDIA4, TBCB, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and PEPD, PDIA4, CEACAM5, PKD1, DCXR and TNC, SERPIN A1, SLAMF8, PEPD, DCXR and ADAMTSL4, AREG, TNC, PKD1, MAMDC4 and DCXR, PDIA4, CE ACAM5, DCXR, ALCAM and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and TNC, AREG, ADAM 12, IL1RAP, PLXDC2 and ALCAM, AREG, PKD1, DCXR, IL1RAP and TBCB, PDIA4, TNC, MAMD C4, CD55 and ADAM12, PDIA4, PKD1, PRTN3, PEPD and TBCB, ADAM12, FGA, MAMDC4, HEG1 and FAP, PDIA4, PKD1, PRTN3, PEPD and AGR3, PDIA4, CLEC3B, PKD1, DCXR and MAMDC4, SE RPINA1, HEG1, IL1RAP, PLXDC2 and PEPD,ADAM12, PDIA4, PKD1, DCXR and NCS1, FGA, SLA MF8, PEPD, HEG1 and ALCAM, SERPINA1, AREG, IL1RAP, PLXDC2 and TBCB, PDIA4, TBCB, PKD1, DCXR and LRG1, PDIA4, PEPD, DCXR, IL1RAP and NCS1, SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1, ADAM12, FGA, AGR3, IL1RAP and DCXR, AREG, ADAM12, PKD1, DCXR and IL17RA, ADAM12, CEACAM5, DCXR, IL1RAP and FGA, TNC, CLEC3B, AGR3, IL1RAP and FAP, FGA, CLEC3B, MAMDC4, HEG1 and AGR3, AREG, MA MDC4, IL1RAP, PLXDC2 and DCXR, CEACAM5, FGA, PEPD, HEG1 and TBCB, AREG, ADAM12, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ITIH3, AREG, PDIA4, CEACAM5, HEG1 and PEPD, PDIA4, ITIH3, PKD1, PEPD and DCXR, CEACAM5, AGR3, HEG1, PRDX1 and SERPINA1, ADAM12, AGR3, MAMDC4, IL1RAP and DCXR, AREG, TBCB, PKD1, DCXR and ADAMTSL4, SERPINA1, PKD1, SLAMF8, DCXR and ALCAM, AD AM12, FGA, SLAMF8, NCS1 and IL17RA, PDIA4, PKD1, PEPD, DCXR and MCAM, CEACAM5, AGR3, HEG1, PRDX1 and CLEC3B, AREG, TBCB, PKD1, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and IL17RA, PDIA4, SLAMF8, MCAM, DCXR and PRDX1, FGA, AGR3, SLAMF8, HEG1 and PDI A4, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL4, PDIA4, FAP, DCXR, ALCAM and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and CLEC3B, PDI A4, ADAMTSL4, PKD1, DCXR and SERPINA1,PDIA4, PKD1, DCXR, IL1RAP and IL17RA, ADAM12, TNC, FAP, PRDX1 and NCS1, SERPINA1, SLAMF8, DCXR, PLXDC2 and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5, ADAM12, CEACAM5, DCXR, IL1RAP and LRG1, ADAM12, FGA, SLAMF8, NCS1 and SERPINA1, ADAM12, PDIA4, CD55, FAP and IL17RA, SERPINA1, PEPD, IL1RAP, PLXDC2 and MCAM , PDIA4, PEPD, DCXR, IL1RAP and MAMDC4, PDIA4, PEPD, DCXR, IL1RAP and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and LRG1, AREG, PDIA4, CEACAM5, HEG1 and NCS1, PDIA4, TNC, MCAM, DCXR and PRDX1, PDIA4, CEACAM5, PEPD, HEG1 and PRDX1, SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2, PDIA4, ITIH3, PEPD, FAP and ALCAM, CEAC AM5, AGR3, SLAMF8, HEG1 and LRG1, PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4, SERPI NA1, PEPD, IL1RAP, PLXDC2 and DCXR, FGA, SLAMF8, PEPD, HEG1 and CLEC3B, ADAM12, DCXR, IL1RAP, ALCAM and ITIH3, AREG, ADAM12, PKD1, DCXR and MCAM, PDIA4, SLAMF8, MCAM, DCXR and FAP, ADAM12, TNC, AGR3, IL1RAP and TBCB, PDIA4, SLAMF8, MCAM, DCXR and SERPINA1, PDIA4, FGA, PKD1, DCXR and TBCB, PDIA4, FGA, PEPD, HEG1 and TNC, CEACAM M5, ADAMTSL4, HEG1, PRDX1 and MAMDC4, ADAM12, MAMDC4, FAP, PRDX1 and CLEC3B, PDIA4, PKD1, PRTN3, PEPD and NCS1, PDIA4, TBCB, PKD1, DCXR and ADAM12, ADAM12, CEAC AM5, FGA, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PDIA4,CEACAM5, FGA, HEG1, PRDX1 and SERPINA1, CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4, PDIA4, TNC, MAMDC4, CD55 and NCS1, ADAM12, PEPD, FAP, PRDX1 and PDIA4, FGA, SLAMF8, PEPD, HEG1 and TNC, AREG, PDIA4, PKD1, DCXR and CEACAM5, SERPINA1, AREG, PKD1, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and TNC, ADAM12, FGA, AGR3, IL1RAP and CLEC3B, PDIA4, IGFBP2, DCXR, ALCAM and TNC, AREG, ADAM12, HEG1, IL1RAP and PRDX1, EGF9, PEPD and NCS1, ADAM12, PDIA4, DCXR, ALCAM and IL17RA, SERPINA1, ADAM12, FAP, PRDX1 and TBCB, PDIA4, CEACAM5, PKD1, DCXR and FGA, AREG, ADAM12, IL1RAP, PLXDC2 and PDIA4, PDIA4, FGA, PKD1, DCXR and ASPN, CEACAM5, ADAMTSL4, HEG1, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PDIA4, AREG, TNC, MAMDC4, NCS1 and ITIH3, SERPINA1, AREG, FGA, HEG1 and PDIA4, PDIA4, CEACAM5, PEPD, HEG1 and NCS1, CEACAM5, SLAMF8, PEP D, HEG1 and IGFBP2, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF 8, NCS1 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and PEPD, PDIA4, PEPD, FAP, DCXR and NCS1, TNC, CLEC3B, AGR3, IL1RAP and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and PDIA4, PDIA4, PKD1, PRTN3, PEPD and PRDX1, SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8, ADAM12, FGA, AGR3, IL1RAP and PRDX1, PDIA4, ITIH3, PEPD, FAP and CEACAM5,CEACAM5, FGA, HE G1, PRDX1 and IL17RA, ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and IGFBP2, ADAM12, PDIA4, CD55, FAP and MAMDC4, AREG, ADAM12, PKD1, DCXR and CLEC3B, SERPINA1, PKD1, SLAMF8, DCXR and LRG1, CEACAM5, SLAMF8, PEPD, HEG1 and TNC, AREG, TNC, MAMDC4, NCS1 and MCAM, TNC, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, LRG1, FAP, PRDX1 and DCXR, PDIA4, ADAMTSL4, PKD1, DCXR and AGR3, AREG, TNC, PK D1, MAMDC4 and IGFBP2, ADAM12, TBCB, FAP, PRDX1 and DCXR, AREG, PDIA4, PKD1, DCXR and ALCAM, FGA, TBCB, MAMDC4, HEG1 and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and PDI A4, SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM, PDIA4, ITIH3, PKD1, PEPD and IGFBP2, PDI A4, PEPD, DCXR, IL1RAP and ADAMTSL4, AREG, MAMDC4, IL1RAP, PLXDC2 and ALCAM, ADAM12, DCXR, IL1RAP, ALCAM and ADAMTSL4, PDIA4, CEACAM5, DCXR, ALCAM and NCS1, AD AM12, CEACAM5, DCXR, IL1RAP and PRDX1, CEACAM5, SLAMF8, HEG1, DCXR and AGR3, SER PINA1, PEPD, IL1RAP, PLXDC2 and ITIH3, SERPINA1, HEG1, IL1RAP, PLXDC2 and ALCAM, ADA M12, FGA, FAP, PRDX1 and PDIA4, PDIA4, TNC, MAMDC4, CD55 and TBCB, AREG, FGA, PEPD, HEG1 and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and LRG1, ADAM12, PDIA4, DCXR, ALCAM and MCAM, CEACAM5, SLAMF8, HEG1, DCXR and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and MCAM,ADAM12, TNC, FAP, PRDX1 and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and MAMD C4, AREG, PDIA4, DCXR, ALCAM and ADAM12, AREG, TBCB, PKD1, DCXR and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and PEPD, AREG, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, TBCB, PEPD, FAP and ADAMTSL4, SERPINA1, CLEC3B, IL1RAP, PLXDC2 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and NCS1, AREG, MAMDC4, IL1RA P, PLXDC2 and PDIA4, SERPINA1, TNC, DCXR, PLXDC2 and AGR3, ADAM12, CLEC3B, AGR3, IL1RAP and CEACAM5, PDIA4, FGA, PKD1, DCXR and ADAMTSL4, PDIA4, ITIH3, PKD1, PEPD and FAP, PDIA4, FGA, PKD1, DCXR and LRG1, PDIA4, CEACAM5, MEGF9, PEPD and ALCAM, ADAM12, FGA, MAMDC4, HEG1 and TNC, CEACAM5, FG A, HEG1, PRDX1 and PDIA4, ADAM12, CEACAM5, FAP, PRDX1 and ADAMTSL4, PDIA4, TNC, MCAM, DCXR and CLEC3B, PDIA4, TNC, MAMDC4, CD55 and FGA, AREG, FGA, HEG1, IL1RAP and FAP, CEACAM5, FGA, PEPD, HEG1 and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3, PDIA4, PKD1, PRTN3, PEPD and MAMDC4, PDI A4, TNC, PEPD, FAP and ALCAM, AREG, FGA, PEPD, HEG1 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and ASPN, SERPINA1, CEACAM5, CLEC3B, PRDX1 and MAMDC4, ADAM12, FGA, FAP, PRDX1 and IL17RA, PDIA4, FGA, PKD1, DCXR and NCS1, AREG, MAMDC4, IL1RAP, PLXDC 2 and TNC, PDIA4, DCXR, IL1RAP, ALCAM and MAMDC4,SERPINA1, CEACAM5, FGA, HEG1 and AGR3, PDIA4, SLAMF8, MCAM, DCXR and AGR3, AREG, ADAM12, PKD1, DCXR and SERPINA1, PDIA4, IGFBP2, CD55, MCAM and DCXR, PDIA4, FGA, PKD1, DCXR and ALCAM, PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4, PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4, PDIA4, IGFBP2, PKD1, DCXR and LRG1, AREG, ADAM12, PKD1, DC XR and CEACAM5, ADAM12, DCXR, IL1RAP, ALCAM and PRDX1, ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4, PDIA4, PEPD, FAP, DCXR and AGR3, TNC, AGR3, MAMDC4, IL1RAP and TB CB, ADAM12, PDIA4, DCXR, ALCAM and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1 and NCS1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and ALCAM, AREG, PDIA4, CEACAM5, HEG1 and PRDX1, ADAM12, TBCB, FAP, PRDX1 and CLEC3B, PDIA4, PEPD, HEG1, FAP and PRDX1, TNC, AGR3, MAMDC4, IL1RAP and PEPD, ADAM12, CEACAM5, FGA, HEG1 and PDIA4, PDIA4, IGFBP2, DCX R, ALCAM and TBCB, CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA, PDIA4, FGA, PEPD, HEG1 and TBCB, ADAM12, FGA, SLAMF8, NCS1 and ITIH3, AREG, TBCB, PKD1, DCXR and PDIA4, PDIA4, PKD1, PRTN3, PEPD and DCXR, PDIA4, PEPD, FAP, DCXR and CLEC3B, PDIA4, SLAMF8, MCAM, DCXR and MAMDC4, AREG, PDIA4, DCXR, ALCAM and TBCB, SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3, SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4,ADAM12, PDIA4, DCXR, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1 and MAMDC4, AREG, PKD1, DCXR, IL1RAP and FAP, ADAM12, PDIA4, PKD1, DCXR and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and AGR3, PDIA4, TNC, ITIH3, PKD1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and IL17RA, FGA, TBCB, MAMDC4, HEG1 and AGR3, PDIA4, TNC, PEPD, FAP and AGR3, SERPINA1, AREG, PKD1, DCXR and ADAMTSL4, or FGA, AGR3, SLAMF8, HEG1 and SERPINA1 (i.e., the 674 5-marker combinations marked in italics in Table 7).

[0038] Preferably, the A includes a 6-markers combination, and the 6-markers combination is any six of the Bs.

[0039] Preferably, the 6 markers are combined into b1) and b2):

[0040] b1) the 5-markers combination (preferably any one of the 674 5-markers combinations mentioned above);

[0041] b2) any one of the above B;

[0042] The b2) is different from any one of the markers in the combination of 5 markers in b1).

[0043] Preferably, the 6 markers combination is: SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7, PDIA4, CEACAM5, PKD1, DCXR, FGA and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and ITGA11, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PEAR1, CEACAM5, FGA, HEG1, PRDX1, IL17RA and PCDH7, CEACAM5, FGA, PEPD, HEG1, NCS1 and CNTN4, ADAM12, CEACAM5, FGA, H EG1, PDIA4 and CKB, CEACAM5, FGA, PEPD, HEG1, ALCAM and PEAR1, CEACAM5, FGA, PEPD, HEG1, TBCB and NAGPA, AREG, FGA, PEPD, HEG1, CEACAM5 and TINAGL1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and AGR3, CEACAM5, FGA, HEG1, PRDX1, IL17RA and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and DCXR, AREG, FGA, PEPD, HEG1, CEACAM5 and PDIA4, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PCD H7, TNC, AGR3, MAMDC4, IL1RAP, FGA and PRDX1, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and CD58, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PDIA4, AREG, FGA, PEPD, HEG1, CEACAM5 and AGR3, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and TINAGL1, CEACAM5, FGA, PEPD, HEG1, ALCAM and CKB, CEACAM5, FGA, PEPD, HEG1, ALCAM and CD58, PDIA4, CEACAM5, PKD1, DCXR, FGA and NCS1, SERPINA1, CE ACAM5, FGA, HEG1, AGR3 and GDF15, CEACAM5, FGA, HEG1, PRDX1, IL17RA and ITGAV, CE ACAM5, FGA, PEPD, HEG1, NCS1 and TBCB,PDIA4, FGA, PKD1, DCXR, ALCAM and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and ENPP6, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and IGFBP2, CEACAM5, FGA, PEPD, HEG1, ALCAM and IGFBP2, AREG, FGA, PEPD, HEG1, CE ACAM5 and ITGA11, ADAM12, FGA, SLAMF8, NCS1, DCXR and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and GDF15, CEACAM5, FGA, PEPD, HEG1, ALCAM and AGR3, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and COMP, CEACAM5, FGA, PEPD, HEG1, NCS1 and AGR3, CEACAM5, FGA, PEPD, HEG1, ALCAM and ACY1, CEACAM5, FGA, PEPD, HEG1, TNC and PDIA4, AREG, PDIA4, CEACAM5, HEG1, DCXR and PCDH7, FGA, AGR3, SLAMF8, HEG1, LRG1 and PCDH7, FGA, AGR 3, SLAMF8, HEG1, SERPINA1 and PEAR1, CEACAM5, FGA, PEPD, HEG1, ALCAM and ITGA11, AREG, FGA, PEPD, HEG1, CEACAM5 and NAGPA, PDIA4, TNC, MAMDC4, CD55, FGA and CNTN4, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CANT1, CEACAM5, FGA, PEPD, HEG1, NCS1 and PCDH7, AREG, FGA, PEPD, HEG1, CEACAM5 and IGFBP2, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGA11, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CPM. DX1, IL17RA and CPM, SERPINA1, CEACAM5, FGA, HEG1, MCAM and NCS1, FGA, AGR3, SLA MF8, HEG1, SERPINA1 and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, ASPN and CANT1, CEAC AM5, FGA, PEPD, HEG1, NCS1 and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and ACY1,AREG, FGA, PEPD, HEG1, CEACAM5 and PRDX1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CA NT1, PDIA4, SLAMF8, MCAM, DCXR, AGR3 and PCDH7, CEACAM5, FGA, PEPD, HEG1, ALC AM and CA14, AREG, FGA, PEPD, HEG1, CEACAM5 and NCS1, SERPINA1, CEACAM5, FGA, HE G1, MCAM and CNTN4, AREG, FGA, PEPD, HEG1, CEACAM5 and DCXR, CEACAM5, FGA, PEPD, HEG1, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ITGA11, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CNTN4, SERPINA1, CEACAM5, FGA, HEG1, MCAM and APOA4, PDIA 4, CEACAM5, PKD1, DCXR, LRG1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CD58, TNC, AGR3, MAMDC4, IL1RAP, TBCB and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and TINAGL1, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CPM, SERPINA1, CEACAM5, FGA, HEG1, ASPN and PDIA4, SERPINA1, CEACAM5, FGA, HEG1, MCAM and ACY1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and AGR3. 1, PRDX1, IL17RA and ITGA11, CEACAM5, FGA, PEPD, HEG1, NCS1 and TINAGL1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and AGR3, PDIA4, TNC, MAMDC4, CD55, ADAMTSL4 and ITGA11, AREG, FGA, PEPD, HEG1, CEACAM5 and CNTN4, PDIA4, FGA, PKD1, DCXR, NCS1 and IGFBP2, CEACAM5, SLAMF8, PEPD, HEG1, TNC and PDIA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and PEAR1, CEACAM5, FGA, PEPD, HEG1, ALCAM and NCS1,CEACAM5, FGA, PEPD, HEG1, NCS1 and CD34, SERPINA1, CEA CAM5, FGA, HEG1, AGR3 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and CNTN4, FGA, TBCB, MAMDC4, HEG1, AGR3 and PRDX1, ADAM12, FGA, FAP, PRDX1, MAMDC4 and CA NT1, AREG, PDIA4, CEACAM5, HEG1, PRDX1 and AGR3, CEACAM5, FGA, HEG1, PRDX1, PDI A4 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and TINAGL1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and TBCB, AREG, FGA, PEPD, HEG1, CEACAM5 and PCDH7, SERPINA1, CE ACAM5, FGA, HEG1, AGR3 and CNTN4, TNC, AGR3, MAMDC4, IL1RAP, TBCB and PDIA4, CEA CAM5, FGA, PEPD, HEG1, DCXR and ENPP6, SERPINA1, CEACAM5, FGA, HEG1, MCAM and PE AR1, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CNTN4, CEACAM5, FGA, PEPD, HEG1, NCS1 and CPM, CEACAM5, FGA, PEPD, HEG1, NCS1 and CA14, CEACAM5, FGA, HEG1, PRDX1, IL17RA and ACY1, TNC, AGR3, MAMDC4, IL1RAP, FGA and ENPP6, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4 and DCXR, ADAM12, FGA, MAMDC4, HEG1, TNC and TINA GL1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CD58, PDIA4, CEACAM5, PKD1, DCXR, FGA and CNTN4, PDIA4, TNC, MAMDC4, CD55, FGA and DCXR, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CANT1, AREG, FGA, PEPD, HEG1, CEACAM5 and CD34, PDIA4, CLEC3B, PKD1, DCXR, AGR3 and PCDH7, FGA, TBCB, MAMDC4, HEG1, AGR3 and CEACAM5,CEACAM5, FGA, HEG1, PRDX1, IL17RA and DCX R, AREG, ADAM12, PKD1, DCXR, CEACAM5 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1, PEPD and CFP, CEACAM5, FGA, PEPD, HEG1, ALCAM and TINAGL1, AREG, PDIA4, DCXR, ALCAM, ADAM12 and PEPD, AREG, FGA, PEP D, HEG1, CEACAM5 and TBCB, CEACAM5, FGA, PEPD, HEG1, ALCAM and GDF15, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and DCXR, SERPINA1, CEACAM5, FGA, HEG1, ASPN and PCDH7, SE RPINA1, TNC, DCXR, PLXDC2, AGR3 and IGFBP2, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PRDX1, AREG, FGA, PEPD, HEG1, CEACAM5 and COMP, CEACAM5, FGA, PEPD, HEG1, NCS1 and APOA4, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and TBCB, CEACAM5, FGA, HEG1, PRDX1, IL17RA and PPY, CEACAM5, FGA, PEPD, HEG1, ALCAM and PRDX1, TNC, AGR3, MAM DC4, IL1RAP, FGA and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and PCDH7, PDIA4, TNC, MAMDC4, CD55, TBCB and CPM, PDIA4, CEACAM5, PKD1, DCXR, FGA and PCDH7, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and TINAGL1, ADAM12, CEACAM5, FGA, H EG1, PDIA4 and TBCB, AREG, FGA, PEPD, HEG1, CEACAM5 and CA14, TNC, AGR3, MAMDC4, IL1RAP, FGA and GDF15, CEACAM5, FGA, PEPD, HEG1, TBCB and CFP, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and PCDH7, PDIA4, PKD1, DCXR, IL1RAP, NCS1 and CEACAM5,SERPINA1, CEACAM5, FGA, HEG1, ASPN and CNTN4, AREG, ADAM12, PKD1, DCXR, CEACAM5 and NAGPA, ADAM12, FGA, AGR3, IL1RAP, PRDX1 and CPM, CEACAM5, FG A. HEG1, PRDX1, IL17RA and TINAGL1, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and PCDH7, CEACAM5, FGA, P EPD, HEG1, NCS1 and PRDX1, TNC, AGR3, MAMDC4, IL1RAP, FGA and CNTN4, AREG, FGA, PEPD, HEG1, CEACAM5 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CNTN4, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and DCXR, ADAM12, FGA, AGR3, IL1RAP, CEACAM5 and SPINT1, CEACAM5, FGA, PEPD, HEG1, NCS1 and IL17RA, CEACA M5, SLAMF8, HEG1, DCXR, ALCAM and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA and GDF 15, SERPINA1, CEACAM5, FGA, HEG1, MCAM and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CANT1, ADAM12, TNC, FAP, PRDX1, IGFBP2 and CNTN4, AREG, PDIA4, CEACAM5, HEG1, DCXR and ITGAV, PDIA4, FGA, PKD1, DCXR, ALCAM and CPM, SERPINA1, PDIA4, CE ACAM5, HEG1, SLAMF8 and MFGE8, ADAM12, FGA, MAMDC4, HEG1, TNC and COMP, PDIA4, CEACAM5, PKD1, DCXR, FGA and AGR3, AREG, PDIA4, CEACAM5, HEG1, DCXR and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5 and CANT1, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ACY1, AREG, TBCB, PKD1, DCXR, ALCAM and ITGA11, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and PCDH7,CEACAM5, FGA, HEG1, PRDX1, IL17RA and CANT1, PDIA4, TNC, PEPD, FAP, ALCAM and AGR3, PDIA4, CEACAM5, MEGF9, PEPD, ALCAM and TINAGL1, PDIA4, FGA, PKD1, DCXR, LRG1 and ITGA11, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and CA14, TNC, AG R3, MAMDC4, IL1RAP, FGA and PCDH7, PDIA4, TNC, MAMDC4, CD55, FGA and CANT1, AREG, ADAM12, PKD1, DCXR, CEACAM5 and PEAR1, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and CD55, PDIA4, ITIH3, PKD1, PEPD, FAP and CEACAM5, SERPINA1, CEACAM5, FGA, HEG1, AS PN and COMP, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and PDIA4, CEACAM5, FGA, PEPD, HEG1, TNC and TBCB, TNC, AGR3, MAMD C4, IL1RAP, FGA and TBCB, CEACAM5, FGA, PEPD, HEG1, NCS1 and ITGAV, CEACAM5, SLA MF8, PEPD, HEG1, TNC and ITGA11, TNC, AGR3, MAMDC4, IL1RAP, FGA and TINAGL1, CEAC AM5, FGA, PEPD, HEG1, ALCAM and PCDH7, PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and PCD H7, AREG, FGA, HEG1, IL1RAP, FAP and ITGA11, PDIA4, IGFBP2, DCXR, ALCAM, TNC and TBCB, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CFP, ADAM12, PDIA4, DCXR, ALCA M, TBCB and PCDH7, CEACAM5, FGA, PEPD, HEG1, TBCB and MZB1, CEACAM5, FGA, PEPD, HEG1, ALCAM and PPY, AREG, FGA, PEPD, HEG1, CEACAM5 and CKB, FGA, AGR3, SLAMF8, HEG1, LRG1 and GDF15, CEACAM5, FGA, HEG1, PRDX1, IL17RA and COMP,CEACAM5, FGA, HEG1, PRDX1, PDIA4 and TINAGL1, ADAM12, FGA, AGR3, IL1RAP, PRDX1 and CFP, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TBCB, AREG, PDIA4, CEACAM5, HEG1, DCXR and CD58, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and GDF15, P DIA4, TNC, PEPD, FAP, AGR3 and CANT1, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CD34, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TINAGL1, TNC, AGR3, MAMDC4, IL1RAP, PEPD and TINAGL1, AREG, FGA, PEPD, HEG1, CEACAM5 and ACY1, FGA, AGR3, SLAMF8, HEG1, LRG1 and CPM, CEACAM5, FGA, HEG1, PRDX1, PEPD and MZB1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CA14, CEACAM5, FGA, PEPD, HEG1, ALCAM and PDIA4, AREG, FGA, PEPD, HEG1, CEACAM5 and CDH23, SERPINA1, SLAMF8, PEPD , DCXR, IL17RA and PCDH7, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CD34, PDIA4, CEACAM5, PKD1, DCXR, FGA and ACY1, CEACAM5, FGA, PEPD, HEG1, ALCAM and CNTN4, ADAM12, FGA, FAP, PRDX1, MAMDC4 and CNTN4, ADAM12, FGA, FAP, PRDX1, MA MDC4 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and IL17RA, FGA, AGR3, SLAMF8, HEG1, CEACAM5 and PKD1, FGA, AGR3, SLAMF8, HEG1, LRG1 and CKB, PDIA4, CEACAM5, PKD1, DCXR, FGA and ITGA11, AREG, ADAM12, PKD1, DCXR, CEACAM5 and TNC, CEACAM5, SLAMF8, PEPD, HEG1, TNC and DCXR, AREG, ADAM12, PKD1, DCXR, CEACAM5 and PEPD, AREG, FGA, PEPD, HEG1, CEACAM5 and CFP,SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CPM, CEACAM5, FGA, PEPD, HEG1, NCS1 and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TINAGL1, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and DCXR, CEACAM5, FGA, PEPD, HEG1, NCS1 and TNC, SERPINA1, CEA CAM5, FGA, HEG1, ASPN and PEAR1, ADAM12, PDIA4, DCXR, ALCAM, TBCB and AGR3, ARE G, ADAM12, PKD1, DCXR, SERPINA1 and TNC, SERPINA1, AREG, PKD1, DCXR, ADAMTSL4 and PCDH7, ADAM12, FGA, FAP, PRDX1, MAMDC4 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and NCS1, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5 and CPM, PDIA4, TNC, MA MDC4, CD55, ADAMTSL4 and CPM, AREG, FGA, PEPD, HEG1, CEACAM5 and CPM, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and NCS1, CEACAM5, FGA, PEPD, HEG1, ALCAM and ITGAV, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and MAMDC4, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CANT1, CEACAM5, FGA, PEPD, HEG1, DCXR and CLEC3B, PDIA4, PKD1, DCXR, IL1RAP , PEPD and ENPP6, SERPINA1, AREG, FGA, HEG1, PDIA4 and DPP4, SERPINA1, CLEC3B, IL1RAP, PLXDC2, DCXR and TNC, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CD58, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and TBCB, CEACAM5, SLAMF8, PEPD, HEG1, TNC and AGR3, FGA, TBCB, MAMDC4, HEG1, AGR3 and PEAR1, ADAM12, FGA, FAP, PRDX1, PDIA4 and TBCB,CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and GDF15, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CD58, PDIA4, PEPD, FAP, DCXR, CLEC3B and PEAR1, CEACAM5, FGA, PEPD, HEG1, TNC and NAGPA, FGA, CLEC3B, MAMDC4, HEG1, CEA CAM5 and PCDH7, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and CANT1, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ACY1, CEACAM5, FGA, HEG1, PRDX1, IL17RA and AGR3, PDIA4, TNC, MAMDC4, CD55, FGA and TBCB, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CNTN4, CEAC AM5, SLAMF8, HEG1, DCXR, ALCAM and CANT1, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and CNTN4, AREG, FGA, PEPD, HEG1, MAMDC4 and NCS1, FGA, AGR3, SLAMF8, HEG1, LRG1 and ACY1, FGA, AGR3, SLAMF8, HEG1, CEACAM5 and PDIA4, PDIA4, FGA, PKD1, DCX R, NCS1 and CPM, AREG, ADAM12, PKD1, DCXR, CEACAM5 and CD34, AREG, TNC, PKD1, MAMDC4, IGFBP2 and ACY1, PDIA4, FGA, PKD1, DCXR, ALCAM and TBCB, FGA, TBCB, MAMD C4, HEG1, AGR3 and ITGA11, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and KHK, FGA, TBCB, MAMDC4, HEG1, AGR3 and CNTN4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4 and CEACAM 5, PDIA4, CEACAM5, MEGF9, PEPD, NCS1 and AGR3, AREG, TNC, MAMDC4, NCS1, MCAM and TBCB, ADAM12, DCXR, IL1RAP, ALCAM, PRDX1 and PEPD, AREG, ADAM12, PKD1, DCX R, CEACAM5 and CPM,AREG, FGA, PEPD, HEG1, CEACAM5 and CANT1, AREG, PKD1, DCXR, IL1RAP, FAP and PEPD, AREG, FGA, PEPD, HEG1, MAMDC4 and CEACAM5, SERPINA1, CEACAM M5, FGA, HEG1, AGR3 and TNC, SERPINA1, CEACAM5, FGA, HEG1, MCAM and KHK, PDIA4, CEACAM5, DCXR, ALCAM, NCS1 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and TI NAGL1, CEACAM5, AGR3, HEG1, PRDX1, FGA and PCDH7, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CKB, TNC, AGR3, MAMDC4, IL1RAP, TBCB and COMP, SERPINA1, CEACAM5, FGA, HEG1, ASPN and CPM, CEACAM5, FGA, HEG1, PRDX1, IL17RA and KHK, PDIA4, PKD1, DCXR , IL1RAP, PEPD and ITGA11, CEACAM5, FGA, PEPD, HEG1, ALCAM and APOA4, PDIA4, TNC, MAMDC4, CD55, TBCB and AGR3, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CKB, PDIA4, FGA, PKD1, DCXR, ASPN and PCDH7, TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and CNTN4, ARE G, PKD1, DCXR, IL1RAP, FAP and ITGA11, CEACAM5, FGA, PEPD, HEG1, DCXR and SSC4D, CEACAM5, FGA, PEPD, HEG1, NCS1 and CANT1, AREG, TNC, PKD1, MAMDC4, IGFBP2 and CA NT1, ADAM12, TNC, AGR3, IL1RAP, PDIA4 and CNTN4, PDIA4, PEPD, FAP, DCXR, NCS1 and PCDH7, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and AGR3, TNC, AGR3, MAMDC4, IL1RAP, PDIA4 and CA14, ADAM12, CEACAM5, DCXR, IL1RAP, FGA and PCDH7, CEACAM5, SLAMF8, PEPD, HEG1, TNC and ITGAV, CEACAM5, FGA, PEPD, HEG1, AGR3 and TBCB,AREG, FGA, PEP D, HEG1, CEACAM5 and ENPP6, AREG, FGA, PEPD, HEG1, MAMDC4 and CNTN4, PDIA4, CEA CAM5, MEGF9, PEPD, ALCAM and PCDH7, PDIA4, IGFBP2, DCXR, ALCAM, TNC and PCDH7, PDIA4, FGA, PKD1, DCXR, NCS1 and GDF15, FGA, AGR3, SLAMF8, HEG1, LRG1 and TINAGL1, PDIA4, TNC, ITIH3, PKD1, MAMDC4 and CANT1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and CANT1, ADAM12, FGA, SLAMF8, NCS1, DCXR and CNTN4, CEACAM5, FGA, HEG1, PRDX 1. IL17RA and IGFBP2, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and ITGA11, ADAM12, FGA, AGR3, IL1RAP, PRDX1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CPM, PDIA4, FGA, PKD1, DCXR, ASPN and TBCB, SERPINA1, ADAM12, FAP, PRDX1, TBCB and AGR3, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CPM, CEACAM5, FGA, PEPD, HEG1, ALCAM and CPM, AREG, FGA, HEG1, IL1RAP, FAP and CK B, CEACAM5, TNC, FGA, HEG1, DCXR and IL1R2, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CA14, AREG, FGA, PEPD, HEG1, CEACAM5 and ITGAV, AREG, TBCB, PKD1, DCXR, NCS1 and PEPD, PDIA4, FGA, PKD1, DCXR, ALCAM and IGFBP2, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and IGFBP2, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and CANT1, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CNTN4, AREG, ADA M12, PKD1, DCXR, CEACAM5 and AGR3, ADAM12, CEACAM5, DCXR, IL1RAP, FGA and SSC4D,PDIA4, FGA, PKD1, DCXR, ASPN and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and PCDH7, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CD55, PDIA4, FGA, PKD1, DCXR, NCS1 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and DDC, PDIA4, TNC, PEPD, FAP, AGR3 and CEACAM5, AREG, FGA, PEPD, HEG1, CEACAM5 and CD58, CEACAM5, FGA, PEPD, HEG1, ALCAM and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and GDF15, FGA, TBCB, MAMDC 4. HEG1, AGR3 and TINAGL1, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and CANT1, CEACAM5, TNC, FGA, HEG1, DCXR and TBCB, ADAM12, TNC, FAP, PRDX1, IGFBP2 and CPM, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ITGAV, CEACAM5, FGA, HEG1, PRDX1, IL17RA and TBCB, AREG, FGA, HEG1, IL1RAP, FAP and MAMDC4, PDIA4, SLAMF8, MCAM, DCXR, AGR3 and IGFBP 2, ADAM12, CLEC3B, AGR3, IL1RAP, CEACAM5 and CA14, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGAV, PDIA4, CEACAM5, MEGF9, PEPD, NCS1 and TBCB, PDIA4, FGA, PKD1, DCX R, ADAMTSL4 and CNTN4, AREG, TBCB, PKD1, DCXR, ALCAM and HPGDS, PDIA4, PKD1, DCXR, IL1RAP, NCS1 and SSC4D, ADAM12, FGA, MAMDC4, HEG1, TNC and CD34, PDIA4, CEAC AM5, PKD1, DCXR, LRG1 and CKB, PDIA4, FGA, PKD1, DCXR, ALCAM and PCDH7, PDIA4, CEACAM5, DCXR, ALCAM, NCS1 and TNC, PDIA4, CEACAM5, PKD1, DCXR, FGA and MCAM, PDIA4, TNC, MAMDC4, CD55, FGA and AGR3,PDIA4, ITIH3, PKD1, PEPD, FAP and CANT1, PDIA4, FGA, PKD1, DCXR, NCS1 and CNTN4, ADAM12, PDIA4, DCXR, ALCAM, ADAMTSL4 and CNTN4, AREG, MAMDC4, IL1RAP, PLXDC2, TNC and ITGA11, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PDIA4, ADAM12, PDIA4, CD55, FAP, MAMDC4 and CEACAM5, AREG, PDIA4, PKD1, DCXR, ALCAM and DDC, ADAM12, PDIA4, DCXR, ALCAM, TBCB and CEACAM5, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and TBCB, PDIA4, FGA, PKD1, DCXR, NCS1 and TBCB, PDIA4, CEA CAM5, DCXR, ALCAM, NCS1 and PRDX1, AREG, ADAM12, IL1RAP, PLXDC2, PDIA4 and CD58, AREG, PDIA4, PKD1, DCXR, ALCAM and DPP4, PDIA4, CEACAM5, PKD1, DCXR, FGA and TBC B, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and AGR3, CEACAM5, AGR3, HEG1, PRDX1, AL CAM and DCXR, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and COMP, PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and CKB, AREG, TNC, MAMDC4, NCS1, ITIH3 and CD58, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CKB, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CNTN4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and ACY1, ADAM12, FGA, MAMDC4, HEG1, TNC and ITGAV, AREG, PDIA4, PKD1, DCXR, ALCAM and NCS1, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA and CFP, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and NCS1, FGA, TBCB, MAMDC4, HEG1, SERPINA1 and CNTN4,PDIA4, CEACAM5, PKD1, DCXR, FGA and CKB, ADAM12, FGA, SLAMF8, NCS1, DCXR and PCDH7, CEACAM5, FGA, PEP D, HEG1, NCS1 and ITIH3, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CPM, PDIA4, IGFBP2, PKD1, DCXR, LRG1 and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA and SERPINA1, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and AGR3, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PDI A4, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and ITGA11, ADAM12, DCXR, IL1RAP, ALCAM, PRDX1 and DPP4, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and COMP, SERPINA1, PKD1, SLA MF8, DCXR, LRG1 and CEACAM5, PDIA4, CEACAM5, MEGF9, PEPD, DCXR and FAP, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CNTN4, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and IL17RA, ADAM12, CEACAM5, FAP, PRDX1, ADAMTSL4 and CNTN4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4 and PCDH7, SERPINA1, SLAMF8, PEPD, DCXR, IL17RA and ENPP6, CEACAM5, FGA, HEG1, PRDX1, IL17RA and PDIA4 , CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1, MAMDC4 and PDIA4, ADAM12, CEACAM5, DCXR, IL1RAP, PRDX1 and APOA4, CEACAM5, SLAMF8, PEPD, HEG1, TNC and TBCB, SERPINA1, CEACAM5, FGA, HEG1, MCAM and PPY, CEACAM5, FGA, PEPD, HEG1, ALCAM and CD34, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and TNC, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TNC,SERPINA1, TNC, DCXR, PLXDC2, AGR3 and ACY1, AREG, TNC, PKD1, MAMDC4, IGFBP2 and CD58, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and ACY1, CEACAM5, FGA, HEG1, PRDX1, PEPD and TBCB, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and ITGAV, ADAM12, CEACAM5, FGA, HEG1, PDIA 4 and CD34, PDIA4, FGA, PKD1, DCXR, LRG1 and IGFBP2, TNC, AGR3, MAMDC4, IL1RAP, IG FBP2 and CPM, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5 and ACY1, AREG, FGA, PEPD, HEG1, MAMDC4 and CANT1, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CA14, AREG, TBCB, PKD1, DCXR, ALCAM and CNTN4, PDIA4, FGA, PEPD, HEG1, TBCB and NCS1, PDIA4, ADAMTSL4, PKD 1. DCXR, AGR3 and CANT1, PDIA4, CEACAM5, PEPD, HEG1, NCS1 and COMP, PDIA4, FGA, PEPD, HEG1, TBCB and ITGA11, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and PEAR1, AREG, PKD1, SLAMF8, DCXR, TBCB and LILRA4, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and TI NAGL1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CANT1, ADAM12, FGA, MAMDC4, HE G1, TNC and CEACAM5, AREG, MAMDC4, IL1RAP, PLXDC2, TNC and PDIA4, ADAM12, CEACAM5, FGA, HEG1, PKD1 and PDIA4, SERPINA1, AREG, FGA, HEG1, PDIA4 and ITGA11, FGA, AGR3, SLAMF8, HEG1, LRG1 and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and APOA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and C1QTNF1, TNC, AGR3, MAMDC4, IL1RAP, TBCB and CNTN4,ADAM12, PDIA4, DCXR, ALCAM, TBCB and CPM, PDIA4, FGA, PKD1, DCXR, LR G1 and PEAR1, AREG, FGA, PEPD, HEG1, CEACAM5 and GDF15, AREG, ADAM12, IL1RAP, PL XDC2, PDIA4 and NCS1, FGA, TBCB, MAMDC4, HEG1, SERPINA1 and COMP, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CDH23, AD AM12, FGA, AGR3, IL1RAP, PRDX1 and CKB, ADAM12, AGR3, MAMDC4, IL1RAP, PDIA4 and TINAGL1, ADAM12, FGA, MAMDC4, HEG1, TNC and AGR3, PDIA4, CEACAM5, MEGF9, PEPD, ALCAM and CKB, PDIA4, IGFBP2, DCXR, ALCAM, TNC and PRDX1, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and CANT1, TNC, AGR3, MAMDC4, IL1RAP, PEPD and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and MAMDC4, CEACAM5, FGA, HEG1, PRDX1, IL17RA and NCS 1, CEACAM5, TNC, FGA, HEG1, MAMDC4 and IGFBP2, AREG, PDIA4, CEACAM5, HEG1, PRD X1 and C1QTNF1, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CFP, CEACAM5, FGA, PEPD, HEG1, TNC and PCDH7, FGA, AGR3, SLAMF8, HEG1, LRG1 and CNTN4, CEACAM5, AGR3, HE G1, PRDX1, ALCAM and PDIA4, or SERPINA1, MEGF9, PRTN3, IL1RAP, MCAM and RPGR (i.e., 475 6-marker combinations in Table 8).

[0044] Preferably, the A comprises a combination of 7 markers, and the combination of 7 markers is any seven of the combinations in B.

[0045] Preferably, the 7 markers are combined into c1) and c2):

[0046] c1) the 6-markers combination (preferably any one of the 475 6-markers combinations mentioned above);

[0047] c2) any one of the above B;

[0048] The c2) is different from any one of the markers in the combination of 6 markers in c1).

[0049] Preferably, the 7 markers combination is: ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and HEG1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and LILRA4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5 M5, SPINT1 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and PEAR1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and LILRA4, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and PDI A4,ADAM12,CEACAM5,FGA,HEG1,PDIA4,KHK and ADAMTSL4,ADAM12,SLAMF8,DCXR,IL1RAP,MAMDC4,CEACAM5 and NCS1,ADAM12,CEACAM5,FGA,HEG1,PDIA4,KHK and LILR A4,AREG,ADAM12,PKD1,DCXR,CEACAM5,PEAR1 and COMP,ADAM12,CEACAM5,FGA,HE G1, PDIA4, AGR3 and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and CLEC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and FAP, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and MCAM, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, DCXR and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and AGR3,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and ADA MTSL4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and FAP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and PDIA4, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and NCS1, ADAM12, CEACAM5, DCXR, IL1RAP, FG A, PCDH7 and COMP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and NCS1, ADAM12, SLA MF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and LRCH4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and HEG1, ADAM12, CEACAM5, DCXR, IL 1RAP, FGA, PCDH7 and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and HEG1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MAMDC4, AREG, ADAM12, PKD1, DCXR, CEACAM5, TN C and NCS1, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and IL17RA, AREG, ADAM12, PKD 1, DCXR, CEACAM5, CPM and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and SSC4D,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, COMP and LILRA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and NCS1, TNC, AGR3, MAMD C4, IL1RAP, FGA, PRDX1 and COMP,AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and LILRA4,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and NCS1,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and NCS1,ADAM12, CEACAM5, DCXR, IL1RAP, PRDX1, APOA4 and COMP,ADAM12 , SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and C1QTNF1, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TB CB and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and LILRA4, SERPINA1, CEACAM5, FGA, HEG1, AGR3, CANT1 and IL17RA, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and PDIA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and PRDX1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7 and RAB37,AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and AGR3, ADAM12, FGA, FAP, PRDX1, MAMDC4, CE ACAM5 and AGR3, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and FAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and IL17RA, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and AGR3, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and MCAM, PDIA4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5 and R AB37, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and HEG1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and ITGA11, AREG, FGA, PEPD, HEG1, CEACAM5, DCXR and PEAR1, ADA M12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1, ALCAM, CA14 and DPP4, SERPINA1, CEACAM5, FGA, HEG1, MCAM, PEAR1 and PCDH7, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and IL17RA, ADA M12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and PRDX1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and PRDX1, CEACAM5, SLAMF8, HEG1, DCXR, AGR3, IL17RA and CDH23,ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and AGR3, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and HEG1, TNC, AGR3, MAMDC4, IL1RAP, PEPD, TINAGL1 and HE G1,ADAM12,FGA,AGR3,IL1RAP,PRDX1,CPM and MCAM,ADAM12,CEACAM5,FGA,HEG1,PDIA4,DCXR and LILRA4,ADAM12,CEACAM5,F GA, HEG1, PDIA4, AGR3 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and NCS1, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPI NT1 and FAP, FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5 and IL17RA, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and PCDH7, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and HEG1, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and RTN4R, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and LRCH4, AR EG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and CPM, AREG, FGA, PEPD, HEG1, CEACAM5, NCS1 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and IL17RA, CEACAM5, FGA, PEP D, HEG1, NCS1, PEAR1 and LILRA4,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and IL17RA, CEACAM5, FGA, PEPD, HEG1, ALCAM, TINAGL1 and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and ADAMTSL4, AD AM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAM DC4 and PRDX1, SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and MCAM, ADAM12, FGA, AG R3, IL1RAP, CEACAM5, SPINT1 and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and C1QTNF1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and MAMDC4, ADAM12, CEACAM5, FGA, HEG 1, PDIA4, AGR3 and LRCH4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and PDIA4, CEACAM5, AGR3, HEG1, PRDX1, ALCAM, NCS1 and IL17RA, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and ADAMTSL4, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and PDIA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PCDH7, CEACAM5, SLAMF8, PEPD, HEG1, IG FBP2, TBCB and IL17RA,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and LILRA4, FGA, TBC B, MAMDC4, HEG1, AGR3, CEACAM5 and MCAM, CEACAM5, FGA, HEG1, PRDX1, IL17RA, CN TN4 and IL1RAP, TNC, AGR3, MAMDC4, IL1RAP, PDIA4, CA14 and HEG1, ADAM12, CEACAM5, FG A, HEG1, PDIA4, KHK and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and NCS1, CEACAM5, FGA, PEPD, HEG1, NCS1, CAN1 and FAP. T1 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEA CAM5 and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR3 and IL17RA, PDIA4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5 and COMP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and RAB37, ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and LRCH4, CEACAM5, FGA, PEPD, HEG1, ALCAM, TBCB and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TN4 and CNTN1. C, AGR3, MAMDC4, IL1RAP, FGA, TBCB and MCAM, CEACAM5, FGA, PEPD, HEG1, ALCAM, CKB and IL17RA, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and CLEC3B, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and COMP, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and MCAM, CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15 and IL1RAP,ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and PLXDC2, ADAM12, CEAC AM5, FGA, HEG1, PDIA4, PCDH7 and ESM1, AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1 and RAB37, CEACAM5, SLAMF8, PEPD, HEG1, TNC, CPM and PEAR1, PDIA4, CEACAM5, MEGF9, PEPD, NCS1, AGR3 and RAB37, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and RAB37, CEACAM M5, FGA, PEPD, HEG1, NCS1, ACY1 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR 3 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and MZB1, CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15 and PEAR1, CEACAM5, SLAMF8, HEG1, DCXR, AGR3, PEAR1 and RAB37, ADAM12, CEACAM5, FGA, HEG 1, PDIA4, CNTN4 and GNAS, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and RAB37, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, ASPN, CANT1 and AGR3, ADAM12, CEACAM M5, DCXR, IL1RAP, FGA, PCDH7 and MZB1, ADAM12, FGA, MAMDC4, HEG1, TNC, COMP and PRDX1, AREG, PDIA4, CEACAM5, HEG1, DCXR, PCDH7 and CDH23, ADAM12, FGA, AGR3, IL1RA P, CEACAM5, SPINT1 and CDH23,AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and PRDX1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and HEG1, ADAM12, TNC, AGR3, IL1RAP, PDI A4, CNTN4 and MAMDC4, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and RAB37, PDIA4, CEACAM5, PKD1, DCXR, FGA, PEAR1 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, ITGA11 and IL1RAP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and CKB, CEACAM5, FGA, PEPD, HEG1, NCS1, GDF15 and PEAR1, AD AM12, CEACAM5, FGA, HEG1, PDIA4, KHK and FAP, PDIA4, CEACAM5, PKD1, DCXR, FGA, ITGA11 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and LRCH4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and FAP, AREG, FGA, PEPD, HEG1, CEACAM5, TBCB and ADAMT SL4, AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1 and IL17RA, ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and MCAM, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and NCS1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3, ACY1 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP, FGA, PCDH7 and NCS 1,ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and IL17RA,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and FAP,AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and NCS1, AREG, FGA, PEPD, HEG1, CEACAM5, TBCB and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and MCAM, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, IL17RA and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, COMP and MZ B1, CEACAM5, FGA, HEG1, PRDX1, PDIA4, PEAR1 and RAB37, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and LILRA4, ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, ALCAM, PDIA4 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and MCAM, ADAM12, FGA, AGR3, IL 1RAP, ADAMTSL4, ITGA11 and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and NCS1, AREG, FGA, PEPD, HEG1, CEACAM5, CKB and IL1RAP, AREG, FGA, PEPD, HEG1, CEACAM5, CANT1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, AGR3, TNC and PEAR1, AREG, FGA, PEPD, HEG1, CEACAM5, NCS1 and PCDH7, CEACAM5, FGA, PEPD, HEG1, ALCAM, ACY1 and MCAM, ACAM5, FGA, PEPD, HEG1, TNC, TBCB and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and CLEC3B, SERPINA1, CEACAM5, FGA, HEG1, AGR3, CNTN4 and IL1RAP, SERPINA1, CEA CAM5, FGA, HEG1, AGR3, PDIA4 and IL17RA, TNC, AGR3, MAMDC4, IL1RAP, FGA, ENPP6 and COMP,CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7 and PEAR1, CEACAM5, FGA, PEPD, HEG1, TNC, TBCB and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MA MDC4 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and ADAMTSL4, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, KHK and RAB37, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and PEAR1, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and COMP, ADAM12, CEACAM5, FGA, HE G1, PDIA4, TBCB and C1QTNF1, CEACAM5, FGA, HEG1, PRDX1, PDIA4, ACY1 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, CD58 and CLEC3B, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3 and IL1RAP. A, HEG1, PDIA4, CNTN4 and LILRA4, FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5 and COMP, SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and PCDH7, ADAM12, SLAMF8, DCXR, IL1RA P, MAMDC4, CEACAM5 and COMP, SERPINA1, CEACAM5, FGA, HEG1, MCAM, NCS1 and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA, AGR3 and IL17RA, AREG, ADAM12, PKD1, DCXR, CEAC AM5, PEAR1 and ITGA11, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and MAMDC4, FGA, AGR3, SLAMF8, HEG1, CEACAM5, PDIA4 and IL1RAP, AREG, FGA, PEPD, HEG1, CEACAM5, PDIA4 and IL17RA,AREG, PDIA4, CEACAM5, HEG1, DCXR, PEAR1 and PCDH7, CEACAM5, FGA, PEPD, HEG1, TNC, PDIA4 and IL17RA, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and LILRA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and PCDH7, AREG, ADAM12, PKD1, DCXR, CEA CAM5, CANT1 and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, ITGA11 and HEG1, G, ADAM12, PKD1, DCXR, CEACAM5, TNC and CFP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and FAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and HEG1, TNC, AGR3, MAMDC4, IL1RAP, TBCB, PDIA4 and MCAM, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and LILRA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3, GDF15 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RA P, FGA, PCDH7 and SERPINA1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and MAMDC4, ADA M12, CEACAM5, FGA, HEG1, PDIA4, TBCB and MZB1, TNC, AGR3, MAMDC4, IL1RAP, TBCB, COMP and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and COMP, SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and AGR3, ADAM 12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PRDX1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and NCS1, TNC, AGR3, MAMDC4, IL1RAP, FGA, TBCB and HEG1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and RAB37,AREG, FGA, PEPD, HEG1, CEACAM5, ITGA11 and IL1RAP, AREG, ADAM12, PKD1, DCX R, CEACAM5, CD34 and AGR3, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and NCS1, PDIA4, CEACAM5, MEGF9, PEPD, NCS1, AGR3 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and CDH23, CEACAM5, FGA, PEPD, HEG1, TBCB, MZB1 and IL1RAP AM12, PKD1, DCXR, CEACAM5, PEPD and COMP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and LILRA4, SERPINA1, CEACAM5, FGA, HEG1, MCAM, AGR3 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and CDH23, CEACAM5, SLAMF8, PEPD, HEG1, TN C, PDIA4 and IL1RAP, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and ESM1, ADAM12, CEACAM 5, FGA, HEG1, PDIA4, DCXR and IL17RA, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and PEAR 1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and RTN4R, or AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and APOA4 (i.e., 301 7-marker combinations in Table 9).

[0050] Preferably, the A includes an 8-marker combination, and the 8-marker combination is any eight of the Bs.

[0051] Preferably, the 8 markers are combined into d1) and d2):

[0052] d1) the 7-markers combination (preferably any one of the 301 7-markers combinations mentioned above);

[0053] d2) any one of the above B;

[0054] The d2) is different from any one of the markers in the 7 markers combination in d1).

[0055] Preferably, the 8 markers combination is: ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and LRCH4, ADAM12, CEACAM5, DCXR, IL1RA P, FGA, PCDH7, SERPINA1 and PLXDC2, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG 1 and DCXR, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and HPGDS, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, NCS1 and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and SL AMF8, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, CDH23 and IL1RAP, ADAM12, CE ACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, SERPIN A1 and HPGDS, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19, ADAM12, CEA CAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and MCAM, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and PKD1, ADAM12, CEAC AM5, FGA, HEG1, PDIA4, PCDH7, FAP and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and IL1RAP, ADAM12, FGA, AGR 3. IL1RAP, PRDX1, PCDH7, HEG1 and CEACAM5, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and PEPD,ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and PKD1, AD AM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, COMP and UPB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PCDH7 and IL1RAP, CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and KHK, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and ALCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PCDH7 and C1QTNF1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDI A4 and PLXDC2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CDH23 and IGFBP2, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, and PEAR1 and IGFBP2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, and IL17RA and IGFBP2, AREG, FGA, PEPD, HEG1, CEACAM5, CKB, and IL1RAP and SERPINA1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and RAB37 and PKD1, ADAM12, and FG A, AGR3, IL1RAP, PRDX1, PCDH7, HEG1, ASPN, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM, CLEC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37, NAGP A, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and IGFBP2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and PKD1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and UPB1, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, ESM1 and CANT1,ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and ALCAM, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and CL EC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and SSBP1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MCAM and PCDH7, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, FAP and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and UPB 1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, ADAMTSL4 and CFP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and IGFBP2, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBC B, PEAR1 and CANT1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and KHK, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and TBCB, CEACAM5, SLAMF8, PEPD, HE G1, TNC, PDIA4, IL1RAP and SSC4D, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and SSBP1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, AGR3 and IL1RAP, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDI A4, CNTN4, PCDH7 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and LRC H4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 and IL1RAP, ADAM12, CEACAM 5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and MFGE8, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, RTN4R and CLEC3B,AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, PEAR1 and KRT19, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, C1QTNF1 and PEPD, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, RAB37 and PCDH7, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, ESM1 and SERPI NA1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and PEPD, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MAMDC4 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MFGE8, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RA P with SSC4D, CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP with IL17RA, ADAM12, CE ACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and CANT1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and CLEC3B, ADAM12, C EACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and DCXR, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and MZB1, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, PCDH7 and FAP, AREG, FGA, PEPD, HEG1, CEACAM5, CANT1, PCDH7 and SERPI NA1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and IGFBP2, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, ITGA11 and PCDH7, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, FAP and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, PEAR1 and IGFBP2,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, MAMDC4 and IL1RAP, or ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and C1QTNF1 (i.e., 83 8-marker combinations in Table 10).

[0056] Preferably, the A also includes at least one of E, the union of the E and the A (the aforementioned A not including E) is the B, and the E and the A (the aforementioned A not including E) have no intersection (for example: the A (the aforementioned A not including E) includes SERPINA1, then E is B that only does not include SERPINA1 (that is, the union of E and SERPINA1 is B); the A (the aforementioned A not including E) includes AREG, then E is B that only does not include AREG).

[0057] Preferably, the test sample of the product is selected from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; further, it is body fluid.

[0058] Preferably, the body fluid comprises at least one of blood, lymph, pleural effusion, cerebrospinal fluid, joint fluid, ascites, saliva, lymph, and body fluid; further comprises blood.

[0059] Preferably, the tissue comprises intestinal mucosal tissue.

[0060] Preferably, the blood comprises at least one of serum, plasma, dried blood spots, and whole blood; further comprises serum.

[0061] Preferably, the excrement comprises at least one of urine, feces, and tears.

[0062] Preferably, the test sample is selected from the serum of the subject to be tested.

[0063] Preferably, the subject to be tested includes mammals, such as humans, non-human primates (such as gorillas and apes), rodents (such as rats, mice, and guinea pigs), pets (such as cats and dogs), and livestock (such as horses, cows, sheep, pigs, and rabbits).

[0064] Preferably, the subject to be tested includes humans.

[0065] Preferably, the substance for detecting a marker comprises a substance for quantitatively detecting a marker.

[0066] Preferably, the substance for detecting a marker includes a substance for detecting a marker at a gene level and / or a protein level.

[0067] Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip method, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance technology, immuno-PCR technology, and biotin-avidin technology.

[0068] Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunocoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation analysis, flow cytometry fluorescence resolution, and single molecule detection technology; further comprises enzyme-linked immunosorbent assay; and further comprises double antibody sandwich method.

[0069] Preferably, the substance for detecting the marker is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer.

[0070] Preferably, the substance specific to the marker comprises any one of h1) to h4):

[0071] h1) an antibody that specifically binds to the marker;

[0072] h2) a ligand protein or polypeptide that specifically binds to the marker;

[0073] h3) non-protein compounds that specifically recognize markers;

[0074] h4) Nucleic acid aptamers that specifically recognize markers.

[0075] Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody.

[0076] Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system.

[0077] Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma, for example, the markers may be phospholipids disclosed in CN102680597A.

[0078] Preferably, the product further comprises auxiliary detection reagents for gene expression levels, and the auxiliary detection reagents for gene expression levels include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance.

[0079] Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

[0080] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0081] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0082] The second aspect of the present invention provides a marker combination, which comprises at least two of the B described in the first aspect of the present invention, and can be 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105 , 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, or 75 kind of species.

[0083] Preferably, the marker combination comprises any 2, 3, 4, 5, 6, 7, or 8 of the Bs.

[0084] Preferably, the marker combination is a 2-markers combination, a 3-markers combination, a 4-markers combination, a 5-markers combination, a 6-markers combination, a 7-markers combination or an 8-markers combination in the first aspect of the present invention.

[0085] Preferably, the marker combination is used to distinguish colorectal cancer from colorectal adenoma.

[0086] Preferably, the marker combination is derived from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; further, body fluids.

[0087] Preferably, the subject to be detected, body fluid, tissue, cell, or excrement is the subject to be detected, body fluid, tissue, cell, or excrement in the first aspect of the present invention.

[0088] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0089] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0090] The third aspect of the present invention is to provide a product comprising substances for detecting the marker combination of the second aspect of the present invention.

[0091] Preferably, the product is used to differentiate colorectal cancer from colorectal adenoma.

[0092] Preferably, the substance for detecting the marker combination comprises a substance for quantitatively detecting the marker combination.

[0093] Preferably, the substance for detecting the marker combination comprises a substance for detecting the marker combination at the gene level and / or protein level.

[0094] Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip method, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance technology, immuno-PCR technology, and biotin-avidin technology.

[0095] Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunocoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation analysis, flow cytometry fluorescence resolution, and single molecule detection technology; further comprises enzyme-linked immunosorbent assay; and further comprises double antibody sandwich method.

[0096] Preferably, the substance for detecting the marker combination is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer.

[0097] Preferably, the substance specific to the marker comprises any one of h1) to h4):

[0098] h1) an antibody that specifically binds to the marker;

[0099] h2) a ligand protein or polypeptide that specifically binds to the marker;

[0100] h3) non-protein compounds that specifically recognize markers;

[0101] h4) Nucleic acid aptamers that specifically recognize markers.

[0102] Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody.

[0103] Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system.

[0104] Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma, for example, the markers may be phospholipids disclosed in CN102680597A.

[0105] Preferably, the product further comprises auxiliary detection reagents for gene expression levels, and the auxiliary detection reagents for gene expression levels include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance.

[0106] Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

[0107] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0108] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0109] The fourth aspect of the present invention is to provide a method for constructing a model, which comprises the step of constructing a model using the markers in the first aspect of the present invention.

[0110] Preferably, the method comprises the step of model building using the marker combination according to the second aspect of the present invention.

[0111] Preferably, the model is used to differentiate between colorectal cancer and colorectal adenoma.

[0112] Preferably, the algorithm for constructing the model includes at least one of logarithmic regression, linear discriminant analysis, eigengene linear discriminant analysis, support vector machine, random forest (RandomRest), recursive partitioning tree, XGBoost, ShrunkenCentroids, StepAIC, Kth-Nearest Neighbor, Boosting, neural network, Bayesian network, and hidden Markov model; further includes at least one of random forest (RandomRor est) and XGBoost.

[0113] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0114] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0115] A fifth aspect of the present invention is to provide a device or system comprising:

[0116] Detection module: used to detect the content, activity and / or expression of the marker in the first aspect of the present invention in the test sample; and

[0117] Analysis module: used to input the data acquired by the detection module into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0118] Preferably, the device or system is used to differentiate between colorectal cancer and colorectal adenoma.

[0119] Preferably, the detection module is used to detect the content, activity and / or expression level of the marker combination according to the second aspect of the present invention in a test sample.

[0120] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0121] Preferably, the device or system further comprises: an output module for outputting information according to the analysis results obtained by the analysis module.

[0122] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0123] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0124] A sixth aspect of the present invention provides a computer device, comprising a memory and a processor, wherein the memory stores a program, and when the processor executes the program, it implements any one of the following methods i1) to i2):

[0125] i1) The method for constructing the model according to the fourth aspect of the present invention;

[0126] i2)

[0127] S1: obtaining the content, activity and / or expression of the marker in the first aspect of the present invention in the test sample; and

[0128] S2: Input the data acquired in S1 into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0129] Preferably, S1 in i2) is to obtain the content, activity and / or expression level of the marker combination in the second aspect of the present invention in the test sample.

[0130] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0131] Preferably, i2) further includes the following step: outputting information based on the obtained analysis results.

[0132] The seventh aspect of the present invention provides a computer-storable medium, which includes a stored computer program; wherein, when the computer program is running, the computer-readable storage medium is controlled to implement any one of methods i1) to i2) in the sixth aspect of the present invention.

[0133] The eighth aspect of the present invention provides a method for distinguishing colorectal cancer from colorectal adenoma, comprising the step of detecting the content, expression level and / or activity of the marker in the first aspect of the present invention in a test sample.

[0134] Preferably, the method comprises the step of detecting the content, expression level and / or activity of the marker combination in the second aspect of the present invention in the test sample.

[0135] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0136] Preferably, the product of the first aspect of the present invention is used to detect the content, expression and / or activity of the marker of the first aspect of the present invention in a test sample.

[0137] Preferably, the product of the third aspect of the present invention is used to detect the content, expression level and / or activity of the marker combination of the second aspect of the present invention in a test sample.

[0138] Preferably, the method further comprises the step of inputting the data on the content, expression level and / or activity of the marker in the first aspect of the present invention or the combination of markers in the second aspect of the present invention in the obtained test sample into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0139] Preferably, the method further comprises the step of: outputting information according to the obtained analysis results.

[0140] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; further, it is colorectal advanced adenoma.

[0141] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0142] The beneficial effects of the present invention are:

[0143] The present invention discloses for the first time ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LR G1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEP One or more of D, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SL AMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, and UPB1 are used as markers for distinguishing colorectal cancer from colorectal adenoma. The distinction between colorectal cancer and colorectal adenoma can be achieved by detecting the content, expression level and / or activity of the above markers. BRIEF DESCRIPTION OF THE DRAWINGS

[0144] Figure 1 This is the AUC comparison result of some single-marker RandomForest models and XGBboost models.

[0145] Figure 2 It is the ROC curve diagram of some 2-markers combinations (SERPINA1 and IL17RA; AREG and HEG1).

[0146] Figure 3 This is the result of the AUC comparison of the RandomForest model and the XGBboost model for some 2markers combinations.

[0147] Figure 4 The ROC curves of some 3-markers combinations (AREG, PKD1 and DCXR; SERPINA1, IL17RA and PLXDC2) are shown.

[0148] Figure 5 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 3markers combinations.

[0149] Figure 6 This is the ROC curve diagram of some 4-markers combinations (CEACAM5, FGA, AREG and HEG1; SERPINA1, ADAM12, FAP and PRDX1).

[0150] Figure 7 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 4-markers combinations.

[0151] Figure 8 The ROC curves of some 5-marker combinations (ADAM12, AGR3, MAMDC4, IL1RAP and TNC; CEACAM5, TNC, FGA, HEG1 and DCXR) are shown.

[0152] Figure 9 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 5-markers combinations.

[0153] Figure 10 This is the ROC curve diagram of some 6-markers combinations (SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7; PDIA4, CEACAM5, PKD1, DCXR, FGA and PEAR1).

[0154] Figure 11 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 6-markers combinations.

[0155] Figure 12 This is the ROC curve diagram of some 7-marker combinations (ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4).

[0156] Figure 13 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 7-markers combinations.

[0157] Figure 14This is the ROC curve of some 8-marker combinations (ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN).

[0158] Figure 15 This is the AUC comparison result of the RandomForest model and the XGBboost model for some 8-markers combinations. DETAILED DESCRIPTION

[0159] The present invention is further described in detail below through specific examples.

[0160] It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0161] The experimental methods in the following examples, where specific conditions are not specified, were generally performed under conventional conditions or the conditions recommended by the manufacturers. The materials and reagents used in these examples were commercially available unless otherwise specified.

[0162] The information of the proteins involved in the following examples is shown in Table 1.

[0163] Table 1 Protein information

[0164]

[0165]

[0166]

[0167]

[0168]

[0169] Note: ENSG_Name is the gene name included in the Ensembl database; UNIPROT_SWISSPROT_ACC_Name is the protein name included in the UniProt protein database Swiss-Prot.

[0170] Example 1 Markers for distinguishing colorectal cancer from colorectal adenoma

[0171] 1. Clinical Sample Collection

[0172] In this example, 139 patients diagnosed with colorectal cancer and 39 patients diagnosed with advanced polyps were collected in the hospital. Fresh blood samples were collected before surgery in the hospital, and the protein expression levels in the blood were detected by the protein detection olink platform as markers for modeling and prediction. According to the clinical progression of the patient's disease, the patient group was divided into two groups: 139 cases of colorectal cancer (60 cases in the early stage group and 79 cases in the late stage group) and 39 cases in the colorectal advanced adenoma group. All patients with colorectal cancer and colorectal advanced adenoma were newly diagnosed diseases, and had no other serious diseases or cancers. They had not received surgery or other treatments at the time of sampling. The age range of the colorectal cancer group in the experimental group was 28 to 83 years old, with an average age of 57.6 years old and a male to female ratio of 85:54; the age range of the colorectal advanced adenoma group in the experimental group was 21 to 84 years old, with an average age of 55.2 years old and a male to female ratio of 28:11.

[0173] Sample inclusion criteria:

[0174] Inclusion criteria for the experimental group: (1) patients with confirmed preoperative advanced colorectal adenoma, colon cancer, or rectal cancer; (2) aged 18 to 80 years, regardless of gender; (3) no history of malignant tumors in other parts of the body; (4) no previous treatment with any other form of anti-tumor therapy before resection; (5) no history of blood transfusion in the past three years.

[0175] Sample exclusion criteria: (1) patients diagnosed with colorectal cancer who have completed surgical treatment or received radiotherapy, chemotherapy, and targeted drug treatment; (2) patients with other non-colorectal cancer tumors, or patients with colorectal metastasis from other tumors.

[0176] Clinical manifestations: 1) In the experimental group (patients with colorectal cancer), pathological examination showed the presence of cancer cells. Some patients had bloody stools, colorectal cramps, anemia, weakness and fatigue.

[0177] 2) Control group (patients with advanced adenomas): adenomas that met one or more of the following criteria: a) diameter >10 mm; b) villous components; c) severe dysplasia or high-grade intraepithelial neoplasia. Some patients experienced bloody stools, colorectal cramps, anemia, weakness, and fatigue.

[0178] In this example, the experimental and control groups were patients who visited the Sixth Affiliated Hospital of Sun Yat-sen University between April and August 2023 and were recruited in strict accordance with the above inclusion criteria. A total of 139 patients diagnosed with colorectal cancer and 39 patients diagnosed with advanced colorectal adenomas were recruited. All specimen collections were approved by the Institutional Review Board of the Sixth Affiliated Hospital of Sun Yat-sen University with signed informed consent from the subjects' families.

[0179] 2. Blood Sample Processing

[0180] 5 mL of peripheral venous blood was collected from the patients and healthy controls using EDTA anticoagulant purple-top tubes, centrifuged for 10 minutes, and the upper plasma was collected and stored vertically in a -80°C refrigerator.

[0181] 3. Protein Detection

[0182] In this example, the inventors performed plasma proteomic testing on 178 plasma samples using the proximity extension assay (PEA) platform. Specifically, in the test, 3072 protein-specific antibodies were individually labeled with unique PEA oligonucleotide probes. Each antibody was labeled with two independent and complementary sequences. These bound antibodies were mixed into eight independent 384-well plates, each of which included three protein replicates for inter-plate quality control. During the test, 178 samples were randomly distributed on three different 96-well plates and incubated with antibodies labeled with PEA probes at +4°C overnight. After the immune reaction, the extension and pre-amplification mixture was added to the incubated samples for PCR amplification at room temperature. The PCR amplification products were then mixed before adding the individual sample index sequence, followed by a second PCR amplification. After sample mixing, the generated library was magnetic bead purified and quality controlled on a Bioanalyzer. Finally, sequencing was performed using an Illumina NovaSeq 6000 instrument, using two S1 flow cells with a read length of 2 × 50 bases. Counts of known barcode sequences were then converted to normalized protein expression units (NPX) through a quality control and normalization process, resulting in a total of 2,884 proteins being quantified.

[0183] 4. Construction of a protein marker screening model to distinguish colorectal cancer from colorectal adenoma

[0184] The inventors used the XGBoost machine learning method to evaluate potential proteins that can distinguish colorectal adenoma from colorectal cancer. In order to avoid the bias of sample selection on machine learning modeling, 100 random modelings were performed using the Bootstrap method. In each modeling, 70% (125 cases) of 39 samples of colorectal advanced adenoma and 139 samples of colorectal cancer were selected as the training set (for screening single markers and the construction of models of markers combinations), and the remaining 30% (53 cases) were used as the test set (for verifying the diagnostic efficacy of single markers and markers combinations screened out from the training set).

[0185] (1) The independent predictive ability of each protein in distinguishing colorectal adenoma from colorectal cancer was evaluated by AUC (area under the curve), sensitivity, and specificity. The mean and confidence interval were calculated 100 times. The predictive efficacy of the proteins was ranked, and proteins with AUC greater than 0.7 were screened out.

[0186] (2) The XGBoost machine learning algorithm with no restriction on the number of proteins was used to build a model, and a model with high classification accuracy was screened out. The weight and frequency of each protein in the model were statistically analyzed, thereby identifying four key proteins, AREG, ADAM12, CEACAM5, and SERPINA1, for use in predictive model construction.

[0187] (3) Among the 2884 proteins, the XGBoost machine learning method was used to evaluate the combination of each protein with one of AREG, ADAM12, CEAC AM5, and SERPINA1. The AUC, sensitivity, and specificity were evaluated, and protein combinations with an AUC greater than 0.80 were selected.

[0188] After the above three steps, the proteins obtained in each step were combined to obtain 75 markers: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NA GPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX 3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TN C, UPB1; among them, 64 proteins had significant differences, as shown in Table 2 (wherein, in Table 2: p.adj is the t-test difference-corrected P value, Mean_AP is the average expression value of the protein after standardization in colorectal adenoma, Mean_CRC is the average expression value of the protein after standardization in colorectal cancer, -LogFC is the difference fold of the average expression value between the two groups of samples (mean_CRC-mean_AP; when -LogFC is greater than 0, it indicates that the protein is overexpressed in colorectal adenocarcinoma patients; when -LogFC is less than 0, it indicates that the protein is underexpressed in colorectal cancer patients). The prediction efficacy AUC values ​​of the 75 proteins ranged from 0.553 to 0.7448. Among them, the prediction efficacy AUC values ​​of 64 proteins with significant differences ranged from 0.553 to 0.7448, and the prediction efficacy AUC values ​​of 34 proteins were greater than 0.65, as shown in Table 3 (wherein, Mean_AUC in Table 3 represents the mean AUC of the protein combination in the XGBoost machine learning model for 100 training classifications, sd_AUC represents the standard deviation of the AUC of the 100 training classifications, and Median_AUC represents the median AUC of the 100 training classifications, the same below). It can be seen that the above 75 markers can be used to distinguish colorectal cancer from colorectal adenoma.

[0189] Table 2 64 proteins with significant differences in the training set

[0190]

[0191]

[0192]

[0193] Table 3 34 proteins with prediction efficiency AUC greater than 0.65 in the test set

[0194]

[0195]

[0196] Furthermore, in order to verify the accuracy and stability of the above selected markers, the inventors used the RandomForest machine learning method to conduct modeling and prediction analysis on the 10 markers with better performance. The modeling method is as follows: 70% (125 cases) of 39 colorectal advanced adenoma samples and 139 colorectal cancer samples were randomly selected as training sets, and the remaining 30% (53 cases) were used as test sets. The model was trained 100 times, and then the average AUC of the 100 models was statistically compared with that of XGBboost. The results are as follows: Figure 1 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0197] Among the 75 protein markers mentioned above, the combination marker examples are as follows. Combinations of, but not limited to, 2, 3, 4, 5, 6, 7, and 8 proteins were used, and the AUC, sensitivity, and specificity of each combination were evaluated using the XGBoost machine learning method. The Random Forest machine learning method was used to further verify the combinations with the best results, as follows:

[0198] 2-marker combinations: any two of the above 75 markers are combined, for a total of 2775 combinations, such as SERPINA1 and IL17RA; AREG and HEG1; CLEC3B and SERPINA1; etc. The predictive efficacy AUC values ​​of these 2775 2-marker combinations range from 0.57 to 0.8169 (due to the large number of combinations, the AUC values ​​of the 2-marker combinations are not listed one by one, and only the range values ​​of the AUC values ​​of the 2775 2-marker combinations are given to demonstrate the diagnostic effect of the above 2775 2-marker combinations); among them, some 2-marker combinations with AUC greater than 0.80 are shown in Table 4, and the ROC curves of some 2-marker combinations (SERPINA1 and IL17RA; AREG and HEG1) are shown in Figure 2 As shown in Figure 2, the above 2775 2-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0199] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 3 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0200] Table 4. Some 2-marker combinations with prediction effectiveness AUC greater than 0.80 in the test set

[0201]

[0202]

[0203] 3-marker combination: Based on the results of 2-markers, proteins whose expression levels in combination with other proteins were greater than 0.7 were selected, totaling 33 proteins: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF9, NCS1, PDIA4, PEPD, PKD1, PLXDC2, PR DX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC; that is, any three combinations of the above 33 markers, a total of 5456 combinations, such as: AREG, PKD1 and DCXR; CEACAM5, FGA and HEG1; AREG, ADAM12 and NCS1; etc.; the predictive efficacy AUC values ​​of these 5456 3-marker combinations range from 0.637 to 0.8664 (due to too many combinations, the AUC values ​​of the 3-marker combinations are not listed one by one, and only the AUC values ​​of the 5456 3-marker combinations are given). The range of C values ​​is used to demonstrate the diagnostic effect of the above 5456 3-markers combinations); among them, some 3-markers combinations with AUC greater than or equal to 0.83 are shown in Table 5 (wherein, Mean_AUC in Table 5 represents the average AUC of 100 training classifications of the protein combination in the XGBoost machine learning model, sd_AUC is the standard deviation of the AUC of 100 training classifications, Median_AUC is the median of the AUC of 100 training classifications, specificity is the average specificity of 100 training classifications, sensitivity is the average sensitivity of 100 training classifications, accuracy is the average correct rate of 100 training classifications, PPV is the positive predictive value, and NPV is the negative predictive value, the same below), and the ROC curves of some 3-markers combinations (AREG, PKD1 and DCXR; SERPINA1, IL17RA and PLXDC2) are shown in Figure 5. Figure 4 As shown in Figure 3, the above 5456 3-markers combination can be used to distinguish colorectal cancer from colorectal adenoma.

[0204] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 5 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0205] Table 5 Some 3-marker combinations with prediction effectiveness AUC greater than or equal to 0.83 in the test set

[0206]

[0207]

[0208]

[0209]

[0210]

[0211]

[0212]

[0213]

[0214]

[0215]

[0216]

[0217]

[0218]

[0219] 4-marker combination: any combination of four of the above 33 markers, a total of 40,920 combinations, such as: CEACAM5, FGA, PEPD and HEG1; CEACAM5, FGA, TBCB and HEG1; CEACAM5, FGA, AGR3 and HEG1, etc. The predictive efficacy AUC values ​​of these 40,920 4-marker combinations range from 0.66 to 0.9036. (Due to the large number of combinations, we will not list them one by one.) The AUC values ​​of the kers combinations are shown in Table 6 . Only the range of AUC values ​​of 40,920 4-marker combinations is given to demonstrate the diagnostic effect of the above 40,920 4-marker combinations. Among them, some 4-marker combinations with AUC greater than or equal to 0.86 are shown in Table 6 , with the range of AUC values ​​being 0.86 to 0.9036. The ROC curves of some 4-marker combinations (CEACAM5, FGA, AREG and HEG1; SERPINA1, ADAM12, FAP and PRDX1) are shown in Table 6 . Figure 6As shown in Figure 3, the above 40,920 4-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0220] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 7 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0221] Table 6 Some 4-marker combinations with prediction effectiveness AUC greater than or equal to 0.86 in the test set

[0222]

[0223]

[0224]

[0225]

[0226]

[0227]

[0228]

[0229]

[0230]

[0231]

[0232]

[0233]

[0234]

[0235]

[0236]

[0237]

[0238]

[0239]

[0240]

[0241]

[0242]

[0243]

[0244]

[0245]

[0246]

[0247]

[0248]

[0249]

[0250]

[0251]

[0252]

[0253]

[0254]

[0255]

[0256]

[0257]

[0258]

[0259]

[0260]

[0261]

[0262]

[0263] 5-marker combination: Based on the 4-marker combination, the combination with AUC greater than or equal to 0.86 was selected for further verification. Among these combinations, for combinations with 3 protein duplications, the combination with the highest AUC was retained and the other combinations were eliminated. Finally, 110 combinations were obtained by deduplication (the 4-marker combinations marked in italics in Table 6, i.e., the 110 4-marker combinations in the invention content), and then combined with the remaining 71 proteins, for a total of 7810 combinations, such as: ADAM12, AGR3, MAMDC4, IL1RAP and TNC; PDIA4, PKD1, PEP D, DCXR and TBCB; CEACAM5, TNC, FGA, HEG1 and DCXR; etc.; the predictive efficacy AUC values ​​of these 7810 5-marker combinations range from 0.82 to 0.9377. (Due to the large number of combinations, the AUC values ​​of the 5-marker combinations are not listed one by one. Only the range values ​​of the AUC values ​​of the 7810 5-marker combinations are given to demonstrate the diagnostic effect of the above 7810 5-marker combinations); Among them, some 5-marker combinations with AUC greater than or equal to 0.9246 are shown in Table 7, and the range values ​​of AUC values ​​are 0.9246 to 0.9377. The ROC curves of some 5-marker combinations (ADAM12, AGR3, MAMDC4, IL1RAP and TNC; CEACAM5, TNC, FGA, HEG1 and DCXR) are shown in Table 7. Figure 8 As shown in Figure 3, the above 7810 5-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0264] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 9 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0265] Table 7: Some 5-marker combinations with prediction effectiveness AUC greater than or equal to 0.9246 in the test set

[0266]

[0267]

[0268]

[0269]

[0270]

[0271]

[0272]

[0273]

[0274]

[0275]

[0276]

[0277]

[0278]

[0279]

[0280]

[0281]

[0282]

[0283]

[0284]

[0285]

[0286]

[0287]

[0288]

[0289]

[0290]

[0291]

[0292]

[0293]

[0294]

[0295]

[0296]

[0297] 6-marker combination: Based on the 5-marker combination, the combination with AUC greater than or equal to 0.9246 was selected for further verification. Among these combinations, 674 combinations were obtained after deduplication (the 5-marker combinations marked in italics in Table 7, i.e., the 674 5-marker combinations in the invention content), which were then combined with the remaining 70 proteins, for a total of 47,180 combinations, such as SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7; PDIA4, CEACAM5, PKD1, DCX R, FGA and PEAR1; the predictive efficacy AUC values ​​of these 47180 6-marker combinations ranged from 0.8323 to 0.9415. (Due to the large number of combinations, the AUC values ​​of the 6-marker combinations are not listed one by one. Only the range values ​​of the AUC values ​​of the 47180 6-marker combinations are given to demonstrate the diagnostic effect of the above 47180 6-marker combinations); among them, some 6-marker combinations with AUC greater than or equal to 0.925 are shown in Table 8, and the range values ​​of AUC values ​​are 0.925 to 0.9415. The ROC curves of some 6-marker combinations (SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7; PDIA4, CEACAM5, PKD1, DCXR, FGA and PEAR1) are shown in Table 8. Figure 10 As shown in Figure 3, the above 47,180 6-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0298] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 11 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0299] Table 8 Six-marker combinations with prediction effectiveness AUC greater than or equal to 0.925 in the test set

[0300]

[0301]

[0302]

[0303]

[0304]

[0305]

[0306]

[0307]

[0308]

[0309]

[0310]

[0311]

[0312]

[0313]

[0314]

[0315]

[0316]

[0317]

[0318]

[0319]

[0320]

[0321]

[0322] 7-markers combination: Based on the 6-markers combination, the combination with AUC greater than or equal to 0.925 was selected for further verification, and 475 combinations were obtained (the 6-markers combination in Table 8, i.e., the 475 6-markers combinations in the invention content), which were then combined with the remaining 69 proteins, for a total of 32,775 combinations, such as ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4; AREG, ADAM12, PKD1, DCX R, CEACAM5, PEAR1 and ADAMTSL4; etc.; the predictive efficacy AUC values ​​of these 32775 7-marker combinations ranged from 0.8426 to 0.9486. (Due to the large number of combinations, the AUC values ​​of the 7-marker combinations are not listed one by one. Only the range values ​​of the AUC values ​​of the 32775 7-marker combinations are given to demonstrate the diagnostic effect of the above 32775 7-marker combinations); among them, some 7-marker combinations with AUC greater than or equal to 0.935 are shown in Table 9, and the AUC values ​​ranged from 0.935 to 0.9486. The ROC curves of some 7-marker combinations (ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH 7 and ADAMTSL4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4) are shown as follows Figure 12 As shown in Figure 3, the above 32,775 7-markers combination can be used to distinguish colorectal cancer from colorectal adenoma.

[0323] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 13 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0324] Table 9: Some 7-marker combinations with prediction effectiveness AUC greater than or equal to 0.935 in the test set

[0325]

[0326]

[0327]

[0328]

[0329]

[0330]

[0331]

[0332]

[0333]

[0334]

[0335]

[0336]

[0337]

[0338]

[0339]

[0340] 8-markers combination: Based on the 7-markers combination, the combination with AUC greater than or equal to 0.935 was selected for further verification, and 301 combinations were obtained (the 7-markers combination in Table 9, i.e., the 301 7-markers combinations in the invention content), which were then combined with the remaining 68 proteins, for a total of 20,468 combinations, such as ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; CEACAM5 , SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN, etc.; the predictive efficacy AUC values ​​of these 20468 8-marker combinations ranged from 0.8455 to 0.9398. (Due to the large number of combinations, the AUC values ​​of the 8-marker combinations are not listed one by one. Only the range values ​​of the AUC values ​​of the 20468 8-marker combinations are given to demonstrate the diagnostic effect of the above 20468 8-marker combinations); among them, some 8-marker combinations with AUC greater than or equal to 0.93 are shown in Table 10, and the AUC values ​​ranged from 0.93 to 0.9398. The ROC curves of some 8-marker combinations (ADAM12, CE ACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM 5, AGR3, IL1RAP and KRT19; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN) are shown as follows Figure 14 As shown in Figure 2, the above 20,468 8-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0341] The AUC comparison results of the RandomForest model and the XGBboost model are as follows Figure 15 As shown in the figure, the AUCs of the RandomForest model and the XGBboost model are very consistent: the average AUCs of the 100 random models are basically the same, and the standard deviations SD (black lines) of the AUCs of the 100 random models are also very close, that is, the stability is also very close; this shows the interchangeability of the model algorithms in the implementation scheme.

[0342] Table 10: Some 8-marker combinations with prediction effectiveness AUC greater than or equal to 0.93 in the test set

[0343]

[0344]

[0345]

[0346]

[0347]

[0348] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. Application of detection marker substances in product preparation: The product is used to differentiate colorectal cancer from colorectal adenoma; The marker is A, and A comprises at least one of B; The B group includes: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA 11. ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PK D1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, UPB1.

2. The use according to claim 1, characterized in that: Said A includes any 1, 2, 3, 4, 5, 6, 7, or 8 of said B; Preferably, said A comprises a single marker, and said single marker is any one of said B; Preferably, the single marker is: CLEC3B, IGFBP2, FAP, CEACAM5, AREG, PLXDC2, MEGF9, DPP4, CKB, TNC, CFP, LRG1, ITIH3, FGA, CD34, SERPINA1, HEG1, MAMDC4, MZB1, MCAM, ADAM12, PEPD, AGR3, PTX3, SSC4D, GDF15, ADAMTSL4, ITGA11, NAGPA, CD58, S SBP1, ITGAV, CPM, RTN4R, APOA4, PTH, C1QTNF1, DCXR, UPB1, TINAGL1, CNTN4, IL17RA, MFGE8, CA14, RPGR, ACY1, PKD1 , PEAR1, PDIA4, SLAMF8, PCDH7, NCS1, PPY, KRT19, ENPP6, GNAS, LILRA4, RAB37, HPGDS, ESM1, IL1R2, COMP, KHK, or CDH twenty three; Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, IGFBP2, ADAMTSL4, PEPD, MAMDC4, FGA, CEACAM5, MEGF9, LRG1, ITIH3, TNC, ITGAV, CD34, CKB, SLAMF8, DPP4, HPGDS, KHK, MCAM, AGR3, DCXR, FAP, PKD1, IL1R2, PTX3, RAB37, PLXDC2, MZB1, CPM, or CFP; Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, or IGFBP2.

3. The use according to claim 1, characterized in that: Said A comprises a combination of 2 markers, and said combination of 2 markers is any 2 of said B; Preferably, the 2 markers combination is: SERPINA1 and IL17RA, AREG and HEG1, CLEC3B and SERPINA1, AREG and PKD1, AREG and PEPD, PDIA4 and PEPD, PRDX1 and SERPINA1, DCXR and SERPINA1, AREG and CD55, IL1RAP and SERPINA1, ADAM12 and FAP, PLXDC2 and SERPINA1, PEPD and SERPINA 1, AREG and CD34, PDIA4 and PKD1, AREG and NCS1, ALCAM and PDIA4, or AREG and MCAM; Preferably, said A comprises a combination of 3 markers, and said combination of 3 markers is any 3 of said B; Preferably, the 3 markers combination is any 3 of C, wherein C is: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF9, NCS1, PDIA4, PEPD, PKD1, PLXDC2, PRDX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC; Preferably, the three markers combination is: AREG, PKD1 and DCXR, CEACAM5, FGA and HEG1, AREG, ADAM12 and NCS1, PDIA4, CEACAM5 and HEG1, SERPINA1, IL17RA and PLXDC2, SERPINA1, TBCB and PLXDC2, AREG, FGA and HEG1, PDIA4, PKD1 and PEPD, AREG, CEACAM5 and HEG1, AREG, ADAMTSL4 and PKD1, AREG, ADAM12 and PKD1, PDIA4, PEPD and IL17RA, PDIA4, PEPD and HEG1, TNC, MAMDC4 and MCAM, AREG, TNC and PKD1, SERPINA1, CEACAM5 and HEG1, SERPINA1, CLEC3B and IL17RA, SERPINA1, PDIA4 and PLXDC2, PDIA4, FGA and HEG1, ADAM 12, AGR3 and IL1RAP, SERPINA1, ADAM12 and PRDX1, PDIA4, PEPD and FAP, AREG, CD34 and DCXR, CEACAM5, ADAMTSL4 and HEG1, ADAM12, CEACAM5 and HEG1, SERPINA1, ASPN and PLXDC2, CEACAM5, FGA and MEGF9, PDIA4, TBCB and FAP, SERPINA1, AREG and PLXDC2, PDIA4, PKD1 and DCXR, SERPINA1, IL1RAP and PLXDC2, TNC, MAMDC4 and PLXDC2, FGA, MAMDC4 and HEG1, SERPINA1, PDIA4 and IL17RA, PDIA4, CEACAM5 and PEPD, PDIA4, CEACAM5 and PEPD. M5 and MEGF9, CEACAM5, SLAMF8 and MEGF9, SERPINA1, CLEC3B and IL1RAP, AREG, SLA MF8 and DCXR, PDIA4, ASPN and HEG1, AREG, FGA and PKD1, FGA, SLAMF8 and HEG1, AREG, MCAM and DCXR, PDIA4, ITIH3 and PKD1, SERPINA1, CEACAM5 and MEGF9, SERPINA1, FGA and HEG1, ADAM12, DCXR and IL1RAP, SERPINA1, ADAM12 and NCS1, PDIA4, MCAM and DCXR, AREG, HEG1 and DCXR, SERPINA1, AREG and IL17RA, SERPINA1, SLAMF8 and DCXR, PDIA4, ASPN and PEPD,SERPINA1, CLEC3B and PRDX1, AREG, TBCB and HEG1, TNC, PKD1 and MAMDC4, PDIA4, PKD1 and MAMDC4, PDIA4, IL17RA and ALCAM, PDIA4, TNC and MCAM, AREG, PDIA4 and PKD1, PDIA4, TNC and IL17RA, AREG, ADAMTSL4 and HEG1, SERPINA1, SLA MF8 and PEPD, ADAM12, PDIA4 and PEPD, ADAM12, ITIH3 and PKD1, AREG, HEG1 and MCAM, SERPINA1, TNC and PLXDC2, CEACAM5, HEG1 and PRDX1, PKD1, SLAMF8 and DCXR, ADAM12, FGA and HEG1, PDIA4, ITIH3 and MCAM, PDIA4, FGA and PKD1, SERPINA1, HEG1 and PLXD C2, AREG, PEPD and HEG1, ADAM12, FGA and CD34, ADAM12, FAP and PRDX1, FGA, TBCB and HEG1, CEACAM5, TNC and MEGF9, SERPINA1, PDIA4 and PKD1, AREG, ASPN and PKD1, ADAM12, FGA and PEPD, SERPINA1, FAP and PRDX1, PDIA4, FGA and PEPD, PDIA4, TNC and PK D1, AREG, PDIA4 and PEPD, SERPINA1, ADAMTSL4 and IL17RA, ADAM12, CD55 and FAP, AREG, ASPN and AGR3, AREG, ASPN and IL17RA, SERPINA1, CEACAM5 and IL17RA. GF9 and NCS1, SERPINA1, ADAM12 and PKD1, CEACAM5, TNC and HEG1, PDIA4, MAMDC4 and PLXDC2, PDIA4, IGFBP2 and PKD1, AREG, TBCB and PKD1, SERPINA1, ADAM12 and IL17RA, ADAM12, CEACAM5 and NCS1, SERPINA1, ADAM12 and CLEC3B, AREG, TNC and MCAM, FGA, IGFBP2 and PKD1, AREG, PKD1 and PEPD, ADAM12, TBCB and FAP, AREG, ITIH3 and PKD1, PD IA4, CEACAM5 and IL17RA, AREG, PKD1 and CD55, TNC, IGFBP2 and MCAM, CEACAM5, SLA MF8 and HEG1, AREG, TBCB and CD55,AREG, FAP and IL1RAP, PDIA4, ITIH3 and CD34, AREG, FGA and NCS1, ADAM12, FGA and NCS1, SERPINA1, ADAM12 and PEPD, PDIA4, HEG1 and PLXD C2, SERPINA1, CEACAM5 and PRDX1, SERPINA1, TNC and IL17RA, AREG, ASPN and HEG1, AREG, PDIA4 and IL17RA, PDIA4, PEPD and MCAM, PDIA4, IGFBP2 and CD55, ADAM12, CEACAM M5 and MEGF9, AREG, CEACAM5 and PKD1, AREG, PDIA4 and CD34, AREG, ADAM12 and CD55, AREG, ADAM12 and DCXR, PDIA4, MEGF9 and PEPD, SERPINA1, PKD1 and DCXR, SERPINA1, CLEC3B and ASPN, AREG, ASPN and MCAM, ADAM12, ITIH3 and CD34, SERPINA1, CLEC3B and PLXDC2, AREG, TNC and NCS1, SERPINA1, CEACAM5 and PKD1, SERPINA1, SLAMF8 and HEG 1, AREG, MAMDC4 and PLXDC2, ADAM12, PEPD and FAP, SERPINA1, DCXR and PLXDC2, AREG, ADAMTSL4 and NCS1, AREG, ADAM12 and IL17RA, SERPINA1, AREG and CD55, PDIA4, IGFBP2 and PEPD, SERPINA1, PDIA4 and HEG1, SERPINA1, IL17RA and DCXR, PDIA4, CEACAM 5 and PKD1, SERPINA1, SLAMF8 and PLXDC2, AREG, NCS1 and MCAM, SERPINA1, PKD1 and PL XDC2, ADAM12, ASPN and AGR3, SLAMF8, MCAM and DCXR, PDIA4, PEPD and CD34, CEACAM M5, IGFBP2 and HEG1, AREG, FGA and MEGF9, PDIA4, CEACAM5 and DCXR, AREG, TNC and HEG1, SERPINA1, TNC and PKD1, SERPINA1, CD34 and DCXR, PDIA4, TBCB and HEG1, SERPIN A1, FGA and CLEC3B, ADAM12, CEACAM5 and IL1RAP, SERPINA1, MAMDC4 and PLXDC2, CE ACAM5, ITIH3 and HEG1, CEACAM5 TNC and FAP,SERPINA1, CEACAM5 and DCXR, SERPINA 1, AREG and DCXR, PDIA4, ASPN and MCAM, ADAM12, ITIH3 and CLEC3B, AREG, MCAM and IL1RAP, ADAM12, CEACAM5 and PRDX1, AREG, ADAMTSL4 and CD55, CEACAM5, TNC and MC AM, AREG, PKD1 and PRTN3, AREG, MAMDC4 and HEG1, SERPINA1, AREG and CLEC3B, ARE G, PDIA4 and HEG1, SERPINA1, PRDX1 and PLXDC2, SERPINA1, MEGF9 and IL17RA, SERPINA1, ADAM12 and PLXDC2, AREG, PEPD and NCS1, PDIA4, TBCB and PEPD, ADAM12, TBCB and NCS1, SERPINA1, PDIA4 and MEGF9, SERPINA1, CEACAM5 and IL1RAP, TNC, IGFBP2 and PKD1, PDIA4, C D55 and ALCAM, SERPINA1, AREG and PKD1, AREG, FGA and DCXR, SERPINA1, FAP and PLXDC2, PDIA4, IGFBP2 and ALCAM, SERPINA1, CEACAM5 and PEPD, AREG, AGR3 and IL1RAP, SERPINA1, AGR3 and IL1RAP, ADAM12, FGA and PKD1, AREG, CLEC3B and PKD1, ADAM12, TBCB and PKD1, CEAC AM5, TBCB and HEG1, AREG, PDIA4 and DCXR, AREG, HEG1 and IL1RAP, SERPINA1, ADAM12 and IL1RAP, PDIA4, TNC and PLXDC2, PDIA4, SLAMF8 and PEPD, AREG, TNC and PLXDC2, AREG, FGA and MCAM, PDIA4, PKD1 and ALCAM, PDIA4, PKD1 and PRDX1, ADAM12, FAP and IL1RAP, PDIA4, TBC B and MCAM, SERPINA1, CD34 and IL1RAP, ADAM12, PDIA4 and DCXR, AREG, PKD1 and HEG1, SERPINA1, PEPD and PLXDC2, SERPINA1, HEG1 and PRDX1, PDIA4, DCXR and ALCAM, SERPINA1, ADAM12 and DCXR, SERPINA1, CLEC3B and SLAMF8, AREG, PKD1 and MAMDC4, ADAM12, ASPN and FAP,FGA, MAMDC4 and CD34, AREG, ADAMTSL4 and MCAM, AREG, MAMDC4 and CD55, PDIA4, ADAMTSL4 and PKD1, ADAM12, MAMDC4 and CD34, AREG, PKD1 and ALCAM, ADAMTSL4, SLAMF8 and PEPD, PDIA4, TBCB and PKD1, SERPINA1, IL17RA and CD55, SERPINA1, DCXR and IL1RAP, P DIA4, TBCB and CD34, TNC, ASPN and MCAM, SERPINA1, PKD1 and IL17RA, PDIA4, ITIH3 and PEPD, SERPINA1, CEACAM5 and PLXDC2, ADAM12, ASPN and HEG1, PDIA4, MAMDC4 and MCAM, SERPINA1, ADAM12 and CD34, PDIA4, IGFBP2 and MCAM, AREG, TBCB and FAP, ADAM12, IL 1RAP and ALCAM, CEACAM5, TNC and IL17RA, SERPINA1, TBCB and PRDX1, AREG, ADAM12 and ALCAM, ADAM12, TBCB and IL1RAP, SERPINA1, CLEC3B and CD55, ADAM12, FGA and MAMDC4, PDIA4, TNC and MEGF9, SERPINA1, ADAMTSL4 and HEG1, AREG, PDIA4 and NCS1, SERPINA 1. ADAMTSL4 and PKD1, SERPINA1, PDIA4 and PRDX1, AREG, PDIA4 and CD55, SERPINA1, CEACAM5 and CD34, PDIA4, IL1RAP and ALCAM, SERPINA1, IL17RA and PRDX1, AREG, MAMDC4 and CD34, ADAM12, ITIH3 and NCS1, CEACAM5, FGA and PEPD, AREG, TNC and FAP, SERPINA 1. FGA and IL17RA, AREG, DCXR and IL1RAP, PDIA4, PKD1 and IL17RA, PDIA4, TNC and FAP, FGA, IGFBP2 and HEG1, AREG, IL1RAP and PLXDC2, SERPINA1, CLEC3B and TBCB, ADAM12, PDIA4 and PKD1, AREG, ADAM12 and HEG1, PDIA4, PLXDC2 and ALCAM, ADAM12, PDIA4 and ALCAM, PDIA4, FAP and PRDX1, or SERPINA1, PKD1 and SLAMF8; Preferably, said A comprises a combination of 4 markers, and said combination of 4 markers is any 4 of said B; Preferably, the 4 markers combination is any 4 of the C; Preferably, the four markers combination is: CEACAM5, FGA, PEPD and HEG1, AREG, CEACAM5, FGA and HEG1, ADAM12, CEACAM5, FGA and HEG1, PDIA4, CEACAM5, PEPD, HEG1, CEACAM5, FGA, HEG1 and PRDX1, AREG, PDIA4, DCXR and ALCAM, SERPINA1, CEACAM5, FGA and HEG1, AREG, FGA, HEG1 and IL1RAP, AREG, FGA, PEPD and HEG1, ADAM12, PDIA4, DCXR and ALCAM, PDIA4, PK D1, DCXR and IL1RAP, SERPINA1, ADAM12, FAP and PRDX1, PDIA4, TNC, PEPD and FAP, SERPIN A1, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, PEPD and DCXR, AREG, PDIA4, PKD1 and DCXR, PDIA4, CEACAM5, PKD1 and DCXR, PDIA4, PEPD, FAP and DCXR, SERPINA1, AREG, IL1RAP and PLXDC2, PDIA4, TBCB, PEPD and FAP, AREG, PDIA4, CEACAM5 and HEG1, AREG, ADAM12, FG A and HEG1, SERPINA1, CEACAM5, IL1RAP and PLXDC2, PDIA4, FGA, PKD1 and DCXR, PDIA4, CEACAM5, DCXR and ALCAM, ADAM12, FGA, MAMDC4 and HEG1, PDIA4, FGA, IGFBP2 and PKD1, ADAM12, LRG1, FAP and PRDX1, CEACAM5, TNC, FGA and HEG1, ADAM12, FGA, AGR3 and IL1RAP, SERPINA1, MAMDC4, IL1RAP and PLXDC2, PDIA4, TNC, MCAM and DCXR, SERPINA1, ADAM12, IL1RAP and PLXDC2, ADAM12, CEACAM5, FAP and PRDX1, AREG, ADAM12, PKD1 and DCX R, AREG, PKD1, SLAMF8 and DCXR, TNC, AGR3, MAMDC4 and IL1RAP, ADAM12, TBCB, FAP and PRDX1, PDIA4, CLEC3B, PKD1 and DCXR, PDIA4, FGA, PEPD and HEG1, PDIA4, PEPD, HEG1 and FAP, ADAM12, FGA, FAP and PRDX1,ADAM12, PDIA4, PKD1 and DCXR, PDIA4, SLAMF8, MCAM and DCXR, PDIA4, DCXR, IL1RAP and ALCAM, ADAM12, PEPD, FAP and PRDX1, SERPINA1, AREG, FGA and HEG1, PDIA4, TNC, IGFBP2 and MCAM, SERPINA1, AREG, PKD1 and DCXR, ARE G, TNC, MAMDC4 and NCS1, ADAM12, FAP, PRDX1 and DCXR, AREG, ADAM12, TNC and NCS1, PDIA4, IGFBP2, PKD1 and DCXR, PDIA4, IL17RA, DCXR and ALCAM, ADAM12, CLEC3B, AGR3 and IL1RAP, CEACAM5, AGR3, SLAMF8 and HEG1, SERPINA1, TNC, DCXR and PLXDC2, FGA, AG R3, SLAMF8 and HEG1, PDIA4, CEACAM5, MEGF9 and PEPD, PDIA4, TNC, MAMDC4 and CD55, CEACAM5, SLAMF8, PEPD and HEG1, SERPINA1, SLAMF8, DCXR and PLXDC2, SERPINA1, PEPD, IL1RAP and PLXDC2, SERPINA1, CEACAM5, CLEC3B and PRDX1, PDIA4, TNC, ITIH3 and PKD1, ADAM12, FGA, SLAMF8 and NCS1, TNC, CLEC3B, AGR3 and IL1RAP, PDIA4, TBCB, PKD1 and DCX R, PDIA4, FAP, DCXR and ALCAM, CEACAM5, AGR3, HEG1 and PRDX1, SERPINA1, PDIA4, PK D1 and DCXR, ADAM12, TNC, AGR3 and IL1RAP, PDIA4, PKD1, PRTN3 and PEPD, ADAM12, PDIA4, CD55 and FAP, ADAM12, CEACAM5, DCXR and IL1RAP, SERPINA1, MEGF9, PRTN3 and IL1RAP, AREG, ADAM12, HEG1 and IL1RAP, AREG, MAMDC4, IL1RAP and PLXDC2, CEACAM5, ADAMTSL 4, SLAMF8 and HEG1, ADAM12, AGR3, MAMDC4 and IL1RAP, FGA, CLEC3B, MAMDC4 and HEG1, PDIA4, ITIH3, PEPD and FAP, AREG, ADAM12, IL1RAP and PLXDC2,CEACAM5, ADAMTSL4, HE G1 and PRDX1, FGA, TBCB, MAMDC4 and HEG1, ADAM12, SLAMF8, DCXR and IL1RAP, SERPINA1, PDIA4, CEACAM5 and HEG1, AREG, TBCB, PKD1 and DCXR, AREG, CEACAM5, HEG1 and IL1RAP, PDIA4, ITIH3, PKD1 and PEPD, SERPINA1, TBCB, SLAMF8 and PLXDC2, AREG, TNC, PKD1 and MAMDC4, SERPINA1, PDIA4, MAMDC4 and PLXDC2, ADAM12, DCXR, IL1RAP and ALCAM, FGA, SLAMF8, PEPD and HEG1, PDIA4, IGFBP2, DCXR and ALCAM, SERPINA1, SLAMF8, PEPD and DCX R, PDIA4, ADAMTSL4, PKD1 and DCXR, ADAM12, TNC, FAP and PRDX1, SERPINA1, CLEC3B, IL1RAP and PLXDC2, PDIA4, PRTN3, PEPD and FAP, CEACAM5, SLAMF8, HEG1 and DCXR, PDIA4, MCAM, DCXR and ALCAM, SERPINA1, CEACAM5, HEG1 and IL1RAP, SERPINA1, HEG1, IL1RAP and PLXDC2, AREG, PKD1, DCXR and IL1RAP, AREG, ADAM12, PDIA4 and CD55, ADAM12, MAM DC4, FAP and PRDX1, PDIA4, PEPD, DCXR and IL1RAP, PDIA4, IGFBP2, CD55 and MCAM, CEACAM M5, FGA, TBCB and HEG1, CEACAM5, FGA, AGR3 and HEG1, CEACAM5, FGA, SLAMF8 and HEG1, PDIA4, CEACAM5, FGA and HEG1, CEACAM5, FGA, HEG1 and IL1RAP, CEACAM5, FGA, ADAMT SL4 and HEG1, AREG, FGA, AGR3 and HEG1, PDIA4, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, MAMDC4 and DCXR, AREG, FGA, PKD1 and HEG1, AREG, FGA, MAMDC4 and HEG1, AREG, FGA, TBCB and HEG1, CEACAM5, FGA, HEG1 and DCXR, CEACAM5, FGA, MAMDC4 and HEG1, CEACA M5, FGA, HEG1 and PLXDC2,CEACAM5, FGA, HEG1 and NCS1, CEACAM5, FGA, ASPN and HEG1, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, CEACAM5, IL17RA and DCXR, CEACAM5, FGA, PRTN3 and HEG1, CEACAM5, FGA, IGFBP2 and HEG1, CEACAM5, TNC, AGR3 and HEG1, CEACAM5, FGA, HEG1 and CD34, PDIA4, TNC, PKD1 and DCXR, CEACAM 5. FGA, CLEC3B and HEG1, PDIA4, PKD1, IL17RA and DCXR, CEACAM5, FGA, MEGF9 and HEG1, CEACAM5, FGA, ITIH3 and HEG1, CEACAM5, FGA, LRG1 and HEG1, AREG, FGA, HEG1 and MCAM, ADAM12, CEACAM5, HEG1 and PRDX1, PDIA4, CEACAM5, HEG1 and CD55, AREG, FGA, ASPN and HEG1, AREG, ADAM12, PKD 1 and IL1RAP, AREG, FGA, MEGF9 and HEG1, AREG, ADAM12, PKD1 and NCS1, CEACAM5, FGA, HEG1 and MCAM, PDIA4, SLAMF8, IL17RA and DCXR, PDIA4, PEPD, HEG1 and ALCAM, ADAM12, PDIA4, PEPD and DCXR, AREG, FGA, HEG1 and PLXDC2, PDIA4, TNC, TBCB and FAP, SERPINA 1. ADAM12, NCS1 and PLXDC2, ADAM12, CEACAM5, FGA and NCS1, AREG, FGA, HEG1 and ALCAM, AREG, PDIA4, PKD1 and HEG1, AREG, PDIA4, PEPD and DCXR, AREG, PDIA4, FGA and HEG1, PDIA4, TNC, PKD1 and MAMDC4, PDIA4, CEACAM5, TNC and HEG1, AREG, ADAM12, FGA and PK D1, SERPINA1, MAMDC4, SLAMF8 and PLXDC2, AREG, ADAM12, ITIH3 and NCS1, AREG, FGA, HEG1 and NCS1, PDIA4, CEACAM5, AGR3 and HEG1, AREG, FGA, HEG1 and DCXR, SERPINA1, AREG, DCXR and PLXDC2, AREG, FGA, PKD1 and DCXR, AREG, FGA, ADAMTSL4 and HEG1,SERP INA1, SLAMF8, HEG1 and PLXDC2, PDIA4, FGA, PEPD and FAP, PDIA4, CEACAM5, PEPD and NCS 1, PDIA4, CEACAM5, IL17RA and CD55, ADAM12, PDIA4, DCXR and IL1RAP, AREG, ADAM12, DCXR and IL1RAP, PDIA4, PKD1, DCXR and ALCAM, ADAM12, TNC, MAMDC4 and IL1RAP, AREG, ADAM12, FGA and NCS1, AREG, FGA, PKD1 and IL1RAP, AREG, PDIA4, MCAM and DCXR, AREG, CEACAM5, AGR3 and HEG1, CEACAM5, TNC, SLAMF8 and HEG1, SERPINA1, TNC, IL1RAP and PL XDC2, PDIA4, TNC, PKD1 and PEPD, PDIA4, CEACAM5, MCAM and DCXR, SERPINA1, SLAMF8, IL1RAP and PLXDC2, SERPINA1, AREG, HEG1 and PLXDC2, CEACAM5, FGA, HEG1 and ALCAM, AREG, FGA, HEG1 and PRDX1, PDIA4, FGA, IL17RA and DCXR, PDIA4, TNC, MAMDC4 and FAP, PDIA4, CEACAM5, MAMDC4 and HEG1, ADAM12, CEACAM5, HEG1 and IL1RAP, ADAM12, PDIA4, PEPD and FAP, PDIA4, CEACAM5, HEG1 and FAP, ADAM12, CEACAM5, PEPD and IL1RAP, AREG , TNC, ITIH3 and NCS1, FGA, TBCB, PEPD and HEG1, CEACAM5, FGA, IL17RA and HEG1, ADAM12, FGA, SLAMF8 and HEG1, ADAM12, TNC, DCXR and IL1RAP, ADAM12, CEACAM5, TBCB and HEG1, PDIA4, TNC, IGFBP2 and PKD1, CEACAM5, FGA, HEG1 and FAP, AREG, FGA, PKD1 and NCS1, ADAM12, AGR3, HEG1 and IL1RAP, AREG, FGA, HEG1 and CD55, ADAM12, PDIA4, CD55 and DCXR, AREG, PDIA4, PEPD and HEG1, PDIA4, CEACAM5, PKD1 and PEPD, AREG, FGA, SLAMF8 and HE G1, PDIA4, PKD1, AGR3 and PEPD,SERPINA1, TNC, PKD1 and PLXDC2, PDIA4, PKD1, CD34 and DCXR, AREG, CEACAM5, ADAMTSL4 and HEG1, PDIA4, PEPD, HEG1 and IL1RAP, PDIA4, CEACAM5, PEPD and DCXR, PDIA4, CEACAM5, TNC and FAP, ADAM12, FGA, AGR3 and HEG1, PDIA4, CEACAM5, HEG1 and PRDX1, SERPINA1, SLAMF8, NCS1 and PLXDC2, AREG, ADAM12, HEG1 and CD55, SERPINA1, SLAMF8, NCS1 and PLXDC2. AM5, FGA and MEGF9, AREG, FGA, IL17RA and HEG1, PDIA4, TBCB, PEPD and HEG1, ADAM12, TNC, MAMDC4 and PLXDC2, PDIA4, TBCB, PKD1 and MAMDC4, SERPINA1, CEACAM5, PEPD and IL1RAP, PDIA4, PEPD, FAP and PRDX1, AREG, ADAM12, FAP and IL1RAP, AREG, ADAM12, TB CB and CD55, PDIA4, TNC, MAMDC4 and NCS1, PDIA4, TNC, PKD1 and AGR3, ADAM12, TNC, FA P and IL1RAP, ADAM12, ITIH3, AGR3 and IL1RAP, SERPINA1, ADAM12, TNC and PLXDC2, AREG, AGR3, MAMDC4 and IL1RAP, SERPINA1, PDIA4, PKD1 and PLXDC2, PDIA4, IGFBP2, PEPD and FAP, PDIA4, FGA, PKD1 and MAMDC4, AREG, CEACAM5, IL17RA and HEG1, FGA, MAMDC4, SLAMF 8 and HEG1, PDIA4, IL17RA, MCAM and DCXR, PDIA4, ASPN, PKD1 and PEPD, PDIA4, TBCB, MC AM and DCXR, SERPINA1, CD34, IL1RAP and PLXDC2, ADAM12, FGA, TBCB and HEG1, SERPINA1, CEACAM5, HEG1 and PRDX1, AREG, ADAM12, IGFBP2 and CD55, PDIA4, PKD1, PEPD and HEG1, PDIA4, ITIH3, MCAM and DCXR, ADAM12, CEACAM5, FAP and IL1RAP,PDIA4, ITIH3, PKD1 and DCXR, SERPINA1, DCXR, IL1RAP and PLXDC2, CEACAM5, FGA, FAP and PRDX1, AREG, PKD1, PRTN3 and IL1RAP, SERPINA1, AREG, CD34 and DCXR, PDIA4, CEACAM5, MEGF9 and DCXR, PDIA 4, PEPD, HEG1 and DCXR, AREG, PDIA4, NCS1 and DCXR, SERPINA1, ADAMTSL4, IL1RAP and PL XDC2, PDIA4, TNC, MAMDC4 and PLXDC2, SERPINA1, TNC, MAMDC4 and PLXDC2, ADAM12, AGR3, FAP and IL1RAP, FGA, IGFBP2, HEG1 and IL1RAP, PDIA4, TBCB, CD55 and FAP, CEACAM5, TBCB, SLAMF8 and HEG1, PDIA4, ITIH3, NCS1 and MCAM, SERPINA1, TBCB, IL1RAP and PLXDC2, ADAM12, CEACAM5, TNC and HEG1, AREG, ADAM12, CD55 and IL1RAP, PDIA4, MEGF9, PEPD and FAP, PDIA4, FGA, MAMDC4 and PLXDC2, SERP INA1, PDIA4, DCXR and PLXDC2, SERPINA1, PDIA4, IL1RAP and PLXDC2, SERPINA1, ADAM12, DCXR and PLXDC2, SERPINA1, TNC, NCS1 and PLXDC2, AREG, MAMDC4, HEG1 and IL1RAP, ADAM12, CEACAM5, CD34 and PRDX1, CEACAM5, AGR3, HEG1 and IL1RAP, SERPINA1, CEACAM5, ADAMTSL4 and PEPD, PDIA4, ITIH3, PEPD and MCAM, SERPINA1, PDIA4, TBCB and PLXDC2, CEACAM5, FGA, SLAMF8 and MEGF9, PDIA4, PEP D, FAP and IL1RAP, SERPINA1, PDIA4, PEPD and FAP, SERPINA1, MEGF9, IL1RAP and PLXDC2, CEACAM5, TNC, FAP and PRDX1, AREG, ADAM12, PKD1 and AGR3, AREG, ADAM12, PKD1 and CD 55, SERPINA1, FAP, PRDX1 and DCXR, PDIA4, TNC, MAMDC4 and MCAM,PDIA4, FGA, PKD1 and HEG1, CEACAM5, TNC, HEG1 and PRDX1, PDIA4, FGA, HEG1 and ALCAM, PDIA4, IGFBP2, PKD1 and CD55, PDIA4, FGA, MAMDC4 and HEG1, SERPINA1, ADAM12, CEACAM5 and CD55, ARE G, TNC, PEPD and HEG1, SERPINA1, SLAMF8, MEGF9 and DCXR, PDIA4, MAMDC4, DCXR and ALCAM, SERPINA1, CLEC3B, SLAMF8 and DCXR, ADAM12, FGA, MAMDC4 and IL1RAP, TNC, AGR 3. HEG1 and IL1RAP, AREG, ADAMTSL4, PEPD and HEG1, SERPINA1, PDIA4, IL17RA and PLXDC2, ADAM12, FGA, FAP and CD34, SERPINA1, PDIA4, TNC and PLXDC2, SERPINA1, FGA, HEG1 and PLXDC2, AREG, ASPN, PKD1 and DCXR, AREG, TBCB, CD55 and FAP, FGA, MAMDC4, HEG1 and I L1RAP, SERPINA1, CEACAM5, AGR3 and HEG1, AREG, FGA, HEG1 and FAP, ADAM12, AGR3, SLAMF8 and IL1RAP, PDIA4, ASPN, PEPD and FAP, CEACAM5, MAMDC4, SLAMF8 and HEG1, AREG, ADAM12, CD55 and DCXR, AREG, PDIA4, DCXR and IL1RAP, SERPINA1, PKD1, IL1RAP and PLXD C2, FGA, TBCB, AGR3 and HEG1, AREG, CEACAM5, TBCB and HEG1, AREG, FGA, PKD1 and PEP D, AREG, FGA, MAMDC4 and PLXDC2, TNC, AGR3, MEGF9 and IL1RAP, SERPINA1, SLAMF8, CD55 and PLXDC2, AREG, ADAM12, DCXR and ALCAM, SERPINA1, CEACAM5, HEG1 and PLXDC2, SERPINA1, PDIA4, HEG1 and PLXDC2, AREG, TNC, AGR3 and FAP, PDIA4, MAMDC4, CD34 and DCXR, SERPINA1, AREG, MAMDC4 and PLXDC2, PDIA4, CD55, DCXR and ALCAM, AREG, ADAM 12, FGA and CD34,CEACAM5, TNC, HEG1 and IL1RAP, ADAM12, PDIA4, FAP and PRDX1, PDIA4, TBCB, MAMDC4 and CD55, PDIA4, TNC, FAP and MCAM, AREG, FGA, PKD1 and MAMDC4, PDIA4, PKD1, PRTN3 and DCXR, SERPINA1, CD55, IL1RAP and PLXDC2, SERPINA1, ADAM12, PKD1 and IL1RAP, FGA, IGFBP2, PKD1 and IL1RAP, AREG, PDIA4 , FGA and PKD1, PDIA4, MAMDC4, PEPD and HEG1, SERPINA1, PDIA4, FGA and HEG1, SERPINA1, CEACAM5, TNC and HEG1, SERPINA1, TNC, AGR3 and IL1RAP, PDIA4, TNC, HEG1 and DCXR, PDIA4, CEACAM5, TBCB and HEG1, PDIA4, CEACAM5, CD55 and ALCAM, PDIA4, ADAMTSL4, PKD1 and PEPD, AREG, AGR3, CD34 and IL1RA P, AREG, PDIA4, CD34 and DCXR, ADAM12, ITIH3, CLEC3B and IL1RAP, TNC, LRG1, AGR3 and IL1RAP, PDIA4, CEACAM5, CD34 and DCXR, PDIA4, TNC, ASPN and PEPD, PDIA4, FGA, PKD1 and PEPD, AREG, ADAMTSL4, PKD1 and IL1RAP, PDIA4, TNC, ITIH3 and MCAM, SERPINA1, ADAM12, AGR3 and IL1RAP, PDIA4, CEACAM5, CD55 and DCXR, ADAM12, PDIA4, PKD1 and AGR3, ARE G, CEACAM5, TNC and HEG1, ADAM12, CEACAM5, FGA and MEGF9, SERPINA1, PDIA4, PKD1 and PEPD, CEACAM5, TNC, MEGF9 and IL1RAP, PDIA4, SLAMF8, DCXR and ALCAM, PDIA4, IL17RA, FAP and DCXR, PDIA4, FGA, DCXR and ALCAM, PDIA4, TBCB, MAMDC4 and PLXDC2, PDIA4, TBCB, FAP and DCXR, TNC, TBCB, MAMDC4 and PLXDC2, ADAM12, CD55, FAP and PRDX1, PDIA4, TNC, FAP and PLXDC2,PDIA4, CEACAM5, HEG1 and PLXDC2, AREG, PDIA4, PEPD and FAP, PDIA4, SLAMF8, PEPD and DCXR, TNC, MAMDC4, IL1RAP and PLXDC2, PDIA4, ITIH3, PKD1 and MAMDC4, CEACAM5, ITIH3, TBCB and HEG1, PDIA4, PKD1, MAMDC4 and CD55, SERPINA1, AD AM12, CEACAM5 and NCS1, AREG, ADAM12, CEACAM5 and HEG1, ADAM12, PDIA4, PEPD and IL 1RAP, PDIA4, TNC, IL17RA and DCXR, AREG, CEACAM5, HEG1 and PRDX1, ADAM12, FGA, AG R3 and CD34, PDIA4, PKD1, CD55 and DCXR, AREG, LRG1, IL1RAP and PLXDC2, AREG, TNC, IL1RAP and PLXDC2, AREG, ADAM12, PEPD and NCS1, PDIA4, CEACAM5, PEPD and FAP, AREG, AD AM12, FAP and NCS1, AREG, TBCB, HEG1 and CD55, CEACAM5, ITIH3, ADAMTSL4 and HEG1, SE RPINA1, ADAM12, NCS1 and IL1RAP, SERPINA1, AREG, CEACAM5 and HEG1, SERPINA1, TNC, TBCB and PLXDC2, SERPINA1, AREG, CD55 and DCXR, SERPINA1, FAP, PRDX1 and IL1RAP, SERPI NA1, PDIA4, CD34 and PLXDC2, SERPINA1, SLAMF8, IL17RA and PLXDC2, PDIA4, TNC, AGR3 and FAP, PDIA4, CEACAM5, TNC and MCAM, PDIA4, CD34, DCXR and ALCAM, PDIA4, AGR3, MEG F9 and IL1RAP, PDIA4, CEACAM5, ASPN and HEG1, ADAM12, PDIA4, CD34 and DCXR, SERPINA1, CEACAM5, CLEC3B and HEG1, PDIA4, TNC, PKD1 and MCAM, PDIA4, PEPD, IL17RA and FAP, PDIA4, PEPD, FAP and MCAM, AREG, IGFBP2, PKD1 and IL1RAP, AREG, PDIA4, CD55 and ALCAM, AREG, TNC, MAMDC4 and HEG1,SERPINA1, AREG, PKD1 and IL1RAP, PDIA4, IGFBP2, PKD1 and PEPD, SERPINA1, AREG, PDIA4 and PKD1, ADAM12, FGA, HEG1 and IL1RAP, PDIA4, IGFBP2, MC AM and DCXR, ADAM12, TBCB, MAMDC4 and PLXDC2, SERPINA1, AREG, IL17RA and PLXDC2, FGA, SLAMF8, HEG1 and IL1RAP, ADAM12, LRG1, AGR3 and IL1RAP, AREG, PDIA4, FAP and DCX R, CEACAM5, HEG1, FAP and PRDX1, SERPINA1, CEACAM5, TNC and PLXDC2, AREG, PDIA4, HEG1 and CD55, PDIA4, AGR3, PEPD and FAP, ADAM12, ITIH3, FAP and PRDX1, ADAM12, MAMD C4, IL1RAP and PLXDC2, AREG, PDIA4, TBCB and NCS1, ADAM12, FGA, ITIH3 and NCS1, FGA, AGR3, MEGF9 and IL1RAP, SERPINA1, ADAM12, PKD1 and PLXDC2, PDIA4, PEPD, IL17RA and DCX R, SERPINA1, AREG, PKD1 and PLXDC2, CEACAM5, ASPN, AGR3 and HEG1, PDIA4, MAMDC4, CD55 and ALCAM, AREG, ADAM12, NCS1 and IL1RAP, SERPINA1, AREG, MEGF9 and IL1RAP, PDIA4, AGR3, PEPD and HEG1, PDIA4, TNC, FAP and IL1RAP, ADAM12, ITIH3, PKD1 and PRDX1, AD AM12, ITIH3, NCS1 and IL1RAP, ADAM12, ITIH3, PKD1 and IL1RAP, SERPINA1, CEACAM5, MEG F9 and IL1RAP, PDIA4, MAMDC4, CD55 and ALCAM, AREG, ADAM12, NCS1 and IL1RAP, 3 and IL1RAP, SERPINA1, FGA, HEG1 and IL1RAP, TNC, AGR3, FAP and IL1RAP, ADAM12, SLAMF 8, DCXR and ALCAM, PDIA4, ITIH3, PEPD and HEG1, AREG, TNC, FAP and IL1RAP, SERPINA1, SLAMF8, IL17RA and DCXR,ADAM12, ITIH3, CLEC3B and NCS1, SERPINA1, CLEC3B, FAP and PRD X1, PDIA4, TBCB, MAMDC4 and MCAM, PDIA4, IGFBP2, CD55 and ALCAM, SERPINA1, TNC, IL 17RA and PLXDC2, ADAM12, CEACAM5, CLEC3B and IL1RAP, PDIA4, TNC, IL17RA and MCAM, AREG, PDIA4, CEACAM5 and CD55, ADAM12, TBCB, MAMDC4 and CD55, AREG, CEACAM5, FGA and MEGF9, SERPINA1, AREG, ADAM12 and PLXDC2, SERPINA1, PKD1, DCXR and IL1RAP, SERPI NA1, MAMDC4, IL17RA and PLXDC2, PDIA4, TBCB, PKD1 and PEPD, FGA, AGR3, HEG1 and IL1RAP, ADAM12, CEACAM5, TNC and NCS1, SERPINA1, CEACAM5, SLAMF8 and DCXR, PDIA4, TN C, PKD1 and PLXDC2, AREG, TNC, AGR3 and MEGF9, PDIA4, TNC, ASPN and MCAM, ADAM12, CEACAM5, CD34 and IL1RAP, ADAM12, TNC, AGR3 and FAP, PDIA4, TNC, FAP and DCXR, AREG, ADAM12, AGR3 and NCS1, ADAM12, FGA, AGR3 and NCS1, CEACAM5, PKD1, SLAMF8 and DCXR, PDIA4, PEPD, FAP and CD34, SERPINA1, SLAMF8, PEPD and PLXDC2, AREG, ADAM12, MAMDC 4 and NCS1, PDIA4, IL17RA, CD55 and ALCAM, PDIA4, PEPD, MCAM and DCXR, PDIA4, FGA, HE G1 and IL1RAP, SERPINA1, CEACAM5, PKD1 and DCXR, ADAM12, FGA, PEPD and HEG1, PDIA4, PKD1, PEPD and FAP, PDIA4, CEACAM5, HEG1 and MCAM, SERPINA1, PKD1, DCXR and PLXDC2, PDIA4, PKD1, MEGF9 and DCXR, AREG, FGA, CLEC3B and HEG1, SERPINA1, AGR3, IL1RAP and PL XDC2, ADAM12, PDIA4, FGA and PEPD,AREG, PDIA4, CD55 and PLXDC2, SERPINA1, FGA, IL1RAP and PLXDC2, PDIA4, PKD1, PEPD and ALCAM, SERPINA1, FGA, CLEC3B and HEG1, PDIA4, ADAMTSL4, DCXR and ALCAM, TNC, IGFBP2, PKD1 and IL1RAP, PDIA4, TNC, PKD1 and FAP, SERPINA1, PDIA4, PEPD and HEG1, PDIA4, CEACAM5, MEGF9 and NCS1, SERPINA1, SLAMF8, DCXR and ALCAM, CEACAM5, SLAMF8, HEG1 and PRDX1, ADAM12, PDIA4, MAMDC4 and PLXDC2, AREG, ADAM12, MCAM and DCXR, CEACAM5, TNC, PEPD and FAP, ADAM12, TNC, IGFBP2 and NCS 1, CEACAM5, FGA, CLEC3B and IL1RAP, CEACAM5, FGA, MEGF9 and PRDX1, SERPINA1, CEAC AM5, TBCB and PLXDC2, AREG, FGA, ITIH3 and HEG1, PDIA4, TNC, CD55 and FAP, SERPINA1, AGR3, SLAMF8 and HEG1, FGA, ASPN, AGR3 and HEG1, PDIA4, FGA, AGR3 and HEG1, ADAM12, PKD1, SLAMF8 and DCXR, AREG, TNC, MAMDC4 and CD55, SERPINA1, CEACAM5, PRDX1 and DC XR. ACAM5 and DCXR, SERPINA1, CLEC3B, AGR3 and IL1RAP, CEACAM5, TBCB, ADAMTSL4 and HEG1, SERPINA1, MAMDC4, HEG1 and PLXDC2, PDIA4, PKD1, FAP and DCXR, PDIA4, CD34, MCAM and DCXR, AREG, PKD1, MAMDC4 and DCXR, ADAM12, PDIA4, PEPD and HEG1, AREG, ADAM12, AGR3 and IL1RAP, PDIA4, FGA, MCAM and DCXR, AREG, CEACAM5, PEPD and HEG1, ADAM12, CLEC3B, TBCB and CD34, SERPINA1, PDIA4, DCXR and ALCAM, AREG, FGA, PRTN3 and HEG1,SERPINA1, TNC, FAP and PLXDC2, CEACAM5, TNC, PEPD and HEG1, AREG, ADAM12, NCS1 and PLXDC2, TNC, ITIH3, MAMDC4 and PLXDC2, PDIA4, ITIH3, PKD1 and AGR3, PDIA4, PKD1, MAM DC4 and PRDX1, CEACAM5, TNC, HEG1 and FAP, ADAM12, PDIA4, CD55 and ALCAM, SERPINA1, PDIA4, CLEC3B and IL17RA, FGA, SLAMF8, HEG1 and DCXR, SERPINA1, FGA, PEPD and HEG1, ADAM12, CEACAM5, ITIH3 and IL1RAP, TNC, IGFBP2, MCAM and IL1RAP, CEACAM5, TNC, MAM DC4 and CD55, ADAM12, CEACAM5, HEG1 and FAP, AREG, PDIA4, PKD1 and IL1RAP, ADAM12, PDIA4, PKD1 and PEPD, FGA, CLEC3B, HEG1 and IL1RAP, CEACAM5, TNC, AGR3 and FAP, ADAM12, CEACAM5, CLEC3B and HEG1, AREG, PDIA4, TNC and FAP, ADAM12, CEACAM5, CD34 and DC XR, PDIA4, CEACAM5, HEG1 and IL1RAP, PDIA4, MAMDC4, MCAM and DCXR, ADAM12, CEAC AM5, IL1RAP and PLXDC2, ADAM12, PEPD, DCXR and IL1RAP, AREG, PDIA4, FGA and NCS1, AREG, FGA, ASPN and PKD1, AREG, AGR3, MEGF9 and IL1RAP, PDIA4, TBCB, DCXR and ALCAM, PDIA4, PKD1, PRDX1 and DCXR, AREG, PKD1, CD55 and DCXR, SERPINA1, PRTN3, IL1RAP and PL XDC2, SERPINA1, FGA, AGR3 and HEG1, ADAM12, ITIH3, PEPD and IL1RAP, ADAM12, CEACAM 5. TBCB and CD34, PDIA4, FGA, IGFBP2 and MCAM, PDIA4, IGFBP2, PKD1 and PRDX1, SERPINA1, AREG, ADAM12 and NCS1, SERPINA1, AREG, PDIA4 and CD55, ADAM12, TNC, NCS1 and PLXDC2, PDIA4, CEACAM5, HEG1 and NCS1,PDIA4, PKD1, PEPD and MCAM, SERPINA1, PDIA4, CEACAM5 and IL17RA, PDIA4, TBCB, MAMDC4 and HEG1, PDIA4, MAMDC4, HEG1 and CD55, FGA, TBC B, SLAMF8 and HEG1, SERPINA1, PDIA4, SLAMF8 and PLXDC2, CEACAM5, FGA, IGFBP2 and PRD X1, ADAM12, AGR3, CD34 and IL1RAP, AREG, PDIA4, TNC and HEG1, PDIA4, CEACAM5, ADA MTSL4 and HEG1, SERPINA1, CEACAM5, CD55 and DCXR, PDIA4, CEACAM5, CD34 and ALCAM, PDIA4, PEPD, HEG1 and MCAM, SERPINA1, AREG, CD55 and PLXDC2, AREG, ADAMTSL4, PKD1 and PEPD, SERPINA1, AREG, ADAM12 and CD55, ADAM12, CEACAM5, HEG1 and CD55, ADAM12, TNC, PKD1 and MAMDC4, PDIA4, ADAMTSL4, PEPD and HEG1, ADAM12, CEACAM5, SLAMF8 and HEG1, CEACAM5, HEG1, PRDX1 and DCXR, SERPINA1, CEACAM5, TNC and PKD1, AREG, ADA M12, LRG1 and NCS1, AREG, SLAMF8, PEPD and DCXR, SERPINA1, CEACAM5, IL17RA and PRDX1, AREG, ADAM12, FAP and PRDX1, ADAM12, ITIH3, CLEC3B and CD55, SERPINA1, TNC, AGR3 and MEGF9, ADAM12, FGA, ASPN and HEG1, AREG, ADAM12, AGR3 and HEG1, CEACAM5, FGA, PKD1 and HEG1, AREG, PKD1, MCAM and DCXR, AREG, TNC, MCAM and IL1RAP, ADAM12, TNC, IL1RAP and PLXDC2, PDIA4, FGA, FAP and PRDX1, ADAM12, TBCB, FAP and IL1RAP, PDIA4, CEA CAM5, AGR3 and MEGF9, PDIA4, PEPD, FAP and NCS1, PDIA4, AGR3, MAMDC4 and HEG1, ADAM 12, CLEC3B, DCXR and IL1RAP, SERPINA1, CEACAM5, HEG1 and CD34,ADAM12, CEACAM5, HEG1 and PLXDC2, SERPINA1, MAMDC4, DCXR and PLXDC2, AREG, ITIH3, PKD1 and DCXR, AREG, PDIA4, CD55 and DCXR, ADAM12, CEACAM5, ITIH3 and HEG1, PDIA4, CEACAM5, PKD1 and HEG1, AREG, TNC, PKD1 and IL1RAP, PDIA4, MAMDC4, FAP and PRDX1, CEACAM5, TNC, TBCB and HE G1, SERPINA1, AREG, FGA and PKD1, CEACAM5, TNC, MAMDC4 and HEG1, ADAM12, FGA, PK D1 and MAMDC4, PDIA4, SLAMF8, PEPD and HEG1, ADAM12, FGA, FAP and NCS1, SERPINA1, AREG, PRDX1 and PLXDC2, PDIA4, CEACAM5, MAMDC4 and DCXR, PDIA4, TNC, PKD1 and HEG1, ADAM12, PDIA4, MAMDC4 and CD34, CEACAM5, MEGF9, PRTN3 and IL1RAP, SERPINA1, TBCB, MAMDC4 and PLXDC2, PDIA4, IGFBP2, PEPD and HEG1, SERPINA1, CEACAM5, CLEC3B and IL17RA, AREG, CEACAM5, HEG1 and DCXR, CEACAM5, TNC, PKD1 and HEG1 EACAM5, SLAMF8 and HEG1, SERPINA1, IL17RA, IL1RAP and PLXDC2, PDIA4, CEACAM5, PEPD and MCAM, PDIA4, MAMDC4, CD55 and FAP, AREG, ADAM12, SLAMF8 and DCXR, AREG, PDIA4, TBCB and CD55, SERPINA1, ADAM12, CEACAM5 and HEG1, CEACAM5, ADAMTSL4, MAMDC4 and HEG1, PDIA4, PKD1, MCAM and DCXR, AREG, FGA, MAMDC4 and NCS1, ADAM12, ITIH3, NCS1 and PLXDC2, AREG, TNC, IGFBP2 and NCS1, AREG, ADAM12, HEG1 and NCS1, PDIA4, TNC, PEPD and HEG1, PDIA4, CEACAM5, MEGF9 and HEG1,AREG, PDIA4, IL17RA and NCS1, SERPINA1, FGA, ADAMTSL4 and HEG1, AREG, PDIA4, CD55 and MCAM, ADAM12, PDIA4, CEACAM5 and PEPD, PDIA4, FGA, AGR3 and FAP, TNC, MAMD C4, SLAMF8 and DCXR, ADAM12, CEACAM5, TBCB and CD55, SERPINA1, ADAM12, TNC and NCS 1, SERPINA1, ADAM12, DCXR and IL1RAP, AREG, SLAMF8, MCAM and DCXR, PDIA4, ADAM5 L4, PKD1 and MAMDC4, ADAM12, CEACAM5, HEG1 and CD34, ADAM12, ITIH3, DCXR and IL1RAP, FGA, CLEC3B, TBCB and HEG1, ADAM12, CEACAM5, TBCB and NCS1, PKD1, MAMDC4, SLAMF 8 and DCXR, PDIA4, MCAM, PRDX1 and DCXR, AREG, PDIA4, ADAMTSL4 and PKD1, AREG, PDI A4, CD55 and IL1RAP, ADAM12, MAMDC4, FAP and IL1RAP, SERPINA1, PDIA4, AGR3 and PLXDC2, ADAM12, TBCB, CD55 and FAP, SERPINA1, IL17RA, DCXR and PLXDC2, SERPINA1, TBCB, PEPD and PLXDC2, AREG, ADAM12, TBCB and DCXR, SERPINA1, AREG, DCXR and IL1RAP, SERPIN A1, CEACAM5, SLAMF8 and PLXDC2, AREG, ADAM12, IGFBP2 and NCS1, ADAM12, IGFBP2, AGR3 and IL1RAP, ADAM12, FGA, CLEC3B and HEG1, PDIA4, TNC, TBCB and MCAM, AREG, FGA, PKD1 and AGR3, SERPINA1, CEACAM5, ADAMTSL4 and HEG1, IGFBP2, PKD1, SLAMF8 and DCXR, SERP INA1, ADAM12, SLAMF8 and DCXR, PDIA4, TNC, MEGF9 and PEPD, AREG, TNC, FGA and HEG1, PDIA4, SLAMF8, HEG1 and DCXR, PDIA4, TBCB, CD55 and ALCAM, AREG, PDIA4, ASPN and PKD 1, PDIA4, AGR3, CD55 and FAP,PDIA4, PEPD, CD55 and FAP, ADAM12, CD34, DCXR and IL1RAP, AREG, PDIA4, CEACAM5 and DCXR, ADAM12, CEACAM5, MEGF9 and IL1RAP, CEACAM5, ITIH3, SLAMF8 and HEG1, AREG, PDIA4, PKD1 and PEPD, PDIA4, CLEC3B, DCXR and ALCAM, SERPINA1, CEACAM5, NCS1 and PLXDC2, FGA, IGFBP2, PKD1 and HEG1, AREG, SLAMF8, NCS1 and DCXR, SERPINA1, CEACAM5, IL17RA and DCXR, SERPINA1, ADAM12, CEACAM5 and IL1RAP, AREG, PD IA4, AGR3 and CD55, AREG, CEACAM5, MAMDC4 and HEG1, PDIA4, IGFBP2, CLEC3B and PKD1, ADAM12, FGA, IGFBP2 and NCS1, SERPINA1, ADAM12, MAMDC4 and PLXDC2, AREG, ADAM12, CEACAM5 and NCS1, PDIA4, ITIH3, DCXR and ALCAM, SERPINA1, SLAMF8, MCAM and DCXR, AREG, ADAM12, PDIA4 and NCS1, AREG, FGA, HEG1 and CD34, SERPINA1, AREG, ADAM12 and PKD1, ADAM12, PDIA4, CEACAM5 and HEG1, ADAM12, CEACAM5, SLAMF8 and NCS1, SERPINA1, FGA, HEG1 and PRDX1, PDIA4, TNC, PEPD and MCAM, ADAM12, TNC, FAP and NCS1, AREG, AD AM12, NCS1 and ALCAM, ADAM12, FGA, ITIH3 and HEG1, AREG, PDIA4, TNC and PKD1, AREG, SLAMF8, CD55 and DCXR, SERPINA1, PDIA4, PEPD and IL17RA, ADAM12, CEACAM5, FGA and FA P, AREG, TNC, HEG1 and NCS1, SERPINA1, CEACAM5, DCXR and PLXDC2, CEACAM5, TNC, ITIH3 and HEG1, PDIA4, TNC, FGA and MCAM, AREG, PDIA4, PKD1 and CD55, AREG, CD34, MCA M and DCXR, SERPINA1, PKD1, PRTN3 and DCXR,AREG, PKD1, MAMDC4 and PRDX1, AREG, PDI A4, CD55 and FAP, PDIA4, ASPN, PKD1 and DCXR, AREG, CEACAM5, HEG1 and CD55, SERPINA1, TBCB, CD55 and PLXDC2, AREG, ADAM12, ASPN and CD55, AREG, ADAMTSL4, PEPD and IL1RAP, TNC, ITIH3, FAP and PRDX1, PDIA4, FGA, AGR3 and MEGF9, AREG, PDIA4, ITIH3 and NCS1, PDI A4, HEG1, MCAM and DCXR, AREG, IGFBP2, ADAMTSL4 and PKD1, SERPINA1, PDIA4, ASPN and PLXDC2, ADAM12, TNC, ITIH3 and NCS1, AREG, LRG1, PKD1 and DCXR, TNC, FGA, MAMDC4 and HEG1, SERPINA1, MAMDC4, FAP and PRDX1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4 , TNC, TBCB and PKD1, PDIA4, PKD1, DCXR and PLXDC2, AREG, TNC, PKD1 and HEG1, PDIA4, ASPN, PEPD and HEG1, AREG, ADAM12, CD55 and NCS1, AREG, TNC, PKD1 and PEPD, SERPINA1, TNC, AGR3 and PLXDC2, CEACAM5, FGA, AGR3 and MEGF9, AREG, FGA, MCAM and DCXR, ARE G, SLAMF8, HEG1 and DCXR, SERPINA1, CEACAM5, PEPD and PLXDC2, ADAM12, PDIA4, MCA M and DCXR, PDIA4, PKD1, MAMDC4 and PLXDC2, PDIA4, MAMDC4, IL1RAP and PLXDC2, CEAC AM5, TBCB, MAMDC4 and CD55, SLAMF8, MCAM, DCXR and IL1RAP, SERPINA1, SLAMF8, ME GF9 and IL1RAP, AREG, TNC, MAMDC4 and MCAM, CEACAM5, LRG1, MEGF9 and IL1RAP, ADAM12, ITIH3, CD34 and NCS1, SERPINA1, CEACAM5, PEPD and HEG1, PDIA4, FGA, ITIH3 and PKD1, PDIA4, MCAM, DCXR and IL1RAP, ADAM12, TNC, TBCB and FAP, AREG, TBCB, ADAMTSL4 and PKD1,AREG, ADAM12, TBCB and NCS1, ADAM12, PDIA4, FGA and HEG1, SERPINA1, CLEC3B, CD34 and IL1RAP, SERPINA1, TNC, HEG1 and PLXDC2, SERPINA1, AREG, MEGF9 and CD55, PDIA4, FGA, ASPN and HEG1, PDIA4, PEPD, CD34 and DCXR, AREG, AGR3, HEG1 and IL1RAP, PDIA4, TNC, ITIH3 and FAP, SERPINA1, AREG, TBCB and PLXDC2, SERPINA1, CLEC3B, IL17RA and IL1RAP, PDIA4, PKD1, CD55 and ALCAM, AREG, FGA, MEGF9 and IL1RAP, SERPINA1 TNC, FAP and PRD X1, PDIA4, MAMDC4, HEG1 and MCAM, ADAM12, FGA, PEPD and FAP, CEACAM5, IGFBP2, SL AMF8 and HEG1, ADAM12, AGR3, IL1RAP and PLXDC2, SERPINA1, ADAM12, FGA and NCS1, PDI A4, CD55, DCXR and IL1RAP, SERPINA1, TNC, CLEC3B and IL17RA, PDIA4, PKD1, PEPD and NCS 1, CEACAM5, FGA, MEGF9 and DCXR, PDIA4, MEGF9, DCXR and ALCAM, PDIA4, MAMDC4, MCAM and PRDX1, PDIA4, TBCB, FAP and PRDX1, FGA, MAMDC4, HEG1 and MCAM, PDIA4, PKD1, MAMDC4 and PEPD, AREG, IGFBP2, TBCB and CD55, SERPINA1, PDIA4, CEACAM5 and PEPD, PDI A4, HEG1, DCXR and ALCAM, PDIA4, TNC, HEG1 and MCAM, PDIA4, IGFBP2, TBCB and MCAM, PDIA4, TNC, HEG1 and FAP, SERPINA1, AREG, AGR3 and IL1RAP, SERPINA1, PDIA4, MAMDC4 and CD55, AREG, ADAM12, AGR3 and CD55, ADAM12, FGA, HEG1 and PRDX1, PDIA4, CEACAM5, TNC and PKD1, PDIA4, IL17RA, CD55 and DCXR, AREG, TNC, MEGF9 and CD55, AREG, ADAMTS L4, PEPD and NCS1,FGA, IGFBP2, PKD1 and DCXR, AREG, TNC, MEGF9 and NCS1, PDIA4, MAM DC4, HEG1 and DCXR, PDIA4, MAMDC4, IL17RA and DCXR, SERPINA1, FGA, CLEC3B and IL17RA, ADAM12, TNC, MAMDC4 and FAP, AREG, ADAM12, SLAMF8 and NCS1, SERPINA1, MAMDC4, PLXDC2 and ALCAM, PDIA4, PKD1, SLAMF8 and PEPD, PDIA4, TNC, FAP and PRDX1, PDIA4, TNC, MAMDC4 and DCXR, PDIA4, PKD1, HEG1 and DCXR, ADAM12, TNC, ITIH3 and PKD1, SERPINA1, SLAMF8, CD55 and DCXR, CEACAM5, TNC, ADAMTSL4 and HEG1, CEACAM5, ADAMTSL4, PEP D and HEG1, PDIA4, ASPN, ADAMTSL4 and PEPD, AREG, FGA, PKD1 and MEGF9, PDIA4, MAMDC 4, FAP and PLXDC2, SERPINA1, ADAM12, TBCB and PLXDC2, AREG, FGA, LRG1 and HEG1, SERPI NA1, ADAM12, CD34 and PLXDC2, PDIA4, ASPN, PKD1 and AGR3, SERPINA1, CEACAM5, TNC and MEGF9, PDIA4, TBCB, FAP and IL1RAP, FGA, IGFBP2, PKD1 and PEPD, SERPINA1, AREG, IL 17RA and CD55, PDIA4, TNC, DCXR and ALCAM, PDIA4, CEACAM5, HEG1 and CD34, TNC, AGR3, MAMDC4 and FAP, PDIA4, TBCB, HEG1 and DCXR, PDIA4, TNC, PEPD and PLXDC2, PDIA4, PKD1, PEPD and IL1RAP, PDIA4, CEACAM5, TNC and DCXR, AREG, ADAM12, TNC and PKD1, PDIA4, ASPN, PEPD and CD55, AREG, IGFBP2, PRTN3 and CD55, SERPINA1, AGR3, MEGF9 and IL1RAP, ADA M12, FGA, NCS1 and IL1RAP, FGA, MAMDC4, SLAMF8 and PLXDC2, SERPINA1, PDIA4, TBCB and CD55, AREG, PDIA4, CEACAM5 and PKD1,PDIA4, ITIH3, PKD1 and NCS1, SERPINA1, CEACAM5, CD55 and PLXDC2, SERPINA1, ADAM12, CEACAM5 and PEPD, AREG, FGA, IGFBP2 and NCS1, PDI A4, CEACAM5, TNC and MEGF9, AREG, TNC, AGR3 and NCS1, CEACAM5, ASPN, TBCB and HEG1, ADAM12, TNC, MAMDC4 and NCS1, PDIA4, PKD1, AGR3 and MAMDC4, or AREG, ADAM12, PDI A4 and DCXR; Preferably, the 4 markers combination is: CEACAM5, FGA, PEPD and HEG1, AREG, CEACAM5, FGA and HEG1, ADAM12, CEACAM5, FGA and HEG1, PDIA4, CEACAM5, PEPD, HEG1, CEACAM5, FGA, HEG1 and PRDX1, AREG, PDIA4, DCXR and ALCAM, SERPINA1, CEACAM5, FGA and HEG 1, AREG, FGA, HEG1 and IL1RAP, AREG, FGA, PEPD and HEG1, ADAM12, PDIA4, DCXR and ALCAM, PDIA4, PKD1, DCXR and IL1RAP, SERPINA1, ADAM12, FAP and PRDX1, PDIA4, TN C, PEPD and FAP, SERPINA1, PKD1, SLAMF8 and DCXR, PDIA4, PKD1, PEPD and DCXR, G, PDIA4, PKD1 and DCXR, PDIA4, CEACAM5, PKD1 and DCXR, PDIA4, PEPD, FAP and DCXR, SERPINA1, AREG, IL1RAP and PLXDC2, PDIA4, TBCB, PEPD and FAP, AREG, PDIA4, CEACA M5 and HEG1, AREG, ADAM12, FGA and HEG1, SERPINA1, CEACAM5, IL1RAP and PLXDC2, PDIA4, FGA, PKD1 and DCXR, PDIA4, CEACAM5, DCXR and ALCAM, ADAM12, FGA, MAMD C4 and HEG1, PDIA4, FGA, IGFBP2 and PKD1, ADAM12, LRG1, FAP and PRDX1, CEACAM5, TNC, FGA and HEG1, ADAM12, FGA, AGR3 and IL1RAP, SERPINA1, MAMDC4, IL1RAP and PLX DC2, PDIA4, TNC, MCAM and DCXR, SERPINA1, ADAM12, IL1RAP and PLXDC2, ADAM12, CEACAM5, FAP and PRDX1, AREG, ADAM12, PKD1 and DCXR, AREG, PKD1, SLAMF8 and DCX R, TNC, AGR3, MAMDC4 and IL1RAP, ADAM12, TBCB, FAP and PRDX1, PDIA4, CLEC3B, PKD1 and DCXR, PDIA4, FGA, PEPD and HEG1, PDIA4, PEPD, HEG1 and FAP, ADAM12, FGA, FAP and PRDX1,ADAM12, PDIA4, PKD1 and DCXR, PDIA4, SLAMF8, MCAM and DCXR, PDIA4, DCXR, IL1RAP and ALCAM, ADAM12, PEPD, FAP and PRDX1, SERPINA1, AREG, FGA and HEG 1, PDIA4, TNC, IGFBP2 and MCAM, SERPINA1, AREG, PKD1 and DCXR, AREG, TNC, MAM DC4 and NCS1, ADAM12, FAP, PRDX1 and DCXR, AREG, ADAM12, TNC and NCS1, PDIA4, IG FBP2, PKD1 and DCXR, PDIA4, IL17RA, DCXR and ALCAM, ADAM12, CLEC3B, AGR3 and IL1RAP, CEACAM5, AGR3, SLAMF8 and HEG1, SERPINA1, TNC, DCXR and PLXDC2, FGA, AGR3, SLAMF8 and HEG1, PDIA4, CEACAM5, MEGF9 and PEPD, PDIA4, TNC, MAMDC4 and CD55, CE ACAM5, SLAMF8, PEPD and HEG1, SERPINA1, SLAMF8, DCXR and PLXDC2, SERPINA1, PEP D, IL1RAP and PLXDC2, SERPINA1, CEACAM5, CLEC3B and PRDX1, PDIA4, TNC, ITIH3 and PKD1, ADAM12, FGA, SLAMF8 and NCS1, TNC, CLEC3B, AGR3 and IL1RAP, PDIA4, TBCB, PKD1 and DCXR, PDIA4, FAP, DCXR and ALCAM, CEACAM5, AGR3, HEG1 and PRDX1, SERPIN A1, PDIA4, PKD1 and DCXR, ADAM12, TNC, AGR3 and IL1RAP, PDIA4, PKD1, PRTN3 and PEP D, ADAM12, PDIA4, CD55 and FAP, ADAM12, CEACAM5, DCXR and IL1RAP, SERPINA1, ME GF9, PRTN3 and IL1RAP, AREG, ADAM12, HEG1 and IL1RAP, AREG, MAMDC4, IL1RAP and PLXDC2, CEACAM5, ADAMTSL4, SLAMF8 and HEG1, ADAM12, AGR3, MAMDC4 and IL1RAP, FGA, CLEC3B, MAMDC4 and HEG1, PDIA4, ITIH3, PEPD and FAP, AREG, ADAM12, IL1RAP and PLXDC2,CEACAM5, ADAMTSL4, HEG1 and PRDX1, FGA, TBCB, MAMDC4 and HEG1, ADAM 12, SLAMF8, DCXR and IL1RAP, SERPINA1, PDIA4, CEACAM5 and HEG1, AREG, TBCB, PKD 1 and DCXR, AREG, CEACAM5, HEG1 and IL1RAP, PDIA4, ITIH3, PKD1 and PEPD, SERPINA1, TBCB, SLAMF8 and PLXDC2, AREG, TNC, PKD1 and MAMDC4, SERPINA1, PDIA4, MAMDC4 and PLXDC2, ADAM12, DCXR, IL1RAP and ALCAM, FGA, SLAMF8, PEPD and HEG1, PDIA4, I GFBP2, DCXR and ALCAM, SERPINA1, SLAMF8, PEPD and DCXR, PDIA4, ADAMTSL4, PKD1 and DCXR, ADAM12, TNC, FAP and PRDX1, SERPINA1, CLEC3B, IL1RAP and PLXDC2, PDIA4, PRTN3, PEPD and FAP, CEACAM5, SLAMF8, HEG1 and DCXR, PDIA4, MCAM, DCXR and ALCA M, SERPINA1, CEACAM5, HEG1 and IL1RAP, SERPINA1, HEG1, IL1RAP and PLXDC2, AREG, PKD1, DCXR and IL1RAP, AREG, ADAM12, PDIA4 and CD55, ADAM12, MAMDC4, FAP and PRDX1, PDIA4, PEPD, DCXR and IL1RAP, or PDIA4, IGFBP2, CD55 and MCAM; Preferably, said A comprises a combination of 5 markers, and said combination of 5 markers is any five of said B; Preferably, the 5 markers are combined into a1) and a2): a1) the combination of the four markers; a2) any one of the above B; a2) is different from any one of the markers in the combination of 4 markers in a1); Preferably, the 5 markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC, PDIA4, PKD1, PEPD, DCXR and TBCB, CEACAM5, TNC, FGA, HEG1 and DCXR, PDIA4, PEPD, DCXR, IL1RAP and TNC, CEACAM5, FGA, PEPD, HEG1 and SERPINA1, ADAM12, PEPD, FAP, PRDX1 and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC, PDIA4, PRTN3, PEPD, FAP and DCX R, SERPINA1, ADAM12, IL1RAP, PLXDC2 and TBCB, ADAM12, PDIA4, DCXR, ALCAM and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and LRG1, CEACAM5, ADAMTSL4, HEG1, PRDX1 and PDIA4, PDIA4, PKD1, PEPD, DCXR and MAMDC4, SERPINA1, AREG, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PEPD, FAP, DCXR and MCAM, TNC, AGR3, MAMDC4, IL1RAP and CLE C3B, ADAM12, AGR3, MAMDC4, IL1RAP and SERPINA1, AREG, ADAM12, TNC, NCS1 and PEPD, PDIA4, PEPD, HEG1, FAP and TNC, PDIA4, PKD1, PEPD, DCXR and FAP, SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4, PDIA4, PEPD, FAP, DCXR and TBCB, SERPINA1, CEA CAM5, FGA, HEG1 and MAMDC4, PDIA4, PKD1, PRTN3, PEPD and TNC, SERPINA1, MAMDC 4, IL1RAP, PLXDC2 and ADAMTSL4, ADAM12, MAMDC4, FAP, PRDX1 and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and NCS1, PDIA4, PEPD, HEG1, FAP and DCXR, CEACAM5, SLAMF 8, PEPD, HEG1 and ADAM12, AREG, PDIA4, DCXR, ALCAM and MAMDC4, PDIA4, PKD1, DCXR, IL1RAP and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and MAMDC4,PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, MAMDC4, HEG1 and TBCB, AREG, PDIA4, PK D1, DCXR and MAMDC4, AREG, PDIA4, PKD1, DCXR and TNC, CEACAM5, AGR3, HEG1, PRDX1 and SLAMF8, PDIA4, PKD1, PEPD, DCXR and SERPINA1, ADAM12, DCXR, IL1RAP, AL CAM and TNC, CEACAM5, AGR3, SLAMF8, HEG1 and TBCB, PDIA4, ADAMTSL4, PKD1, DC XR and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and DCXR, PDIA4, FAP, DCXR, ALCAM and PEPD, TNC, AGR3, MAMDC4, IL1RAP and ALCAM, AREG, PKD1, SLAMF8, DCXR and IGF BP2, TNC, AGR3, MAMDC4, IL1RAP and MCAM, ADAM12, AGR3, MAMDC4, IL1RAP and SL AMF8, ADAM12, PDIA4, DCXR, ALCAM and CLEC3B, PDIA4, IL17RA, DCXR, ALCAM and AGR3, PDIA4, MCAM, DCXR, ALCAM and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and DC XR, SERPINA1, HEG1, IL1RAP, PLXDC2 and DCXR, PDIA4, TNC, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and CEACAM5, SERPINA1, PDIA4, PKD1, DCXR and TBCB, SERPIN A1, ADAM12, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and TNC, ADAM12, FGA, MAMDC4, HEG1, ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and TNC, AREG, MAMDC4, IL1RAP, PLXDC2 and FAP, TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4, PDIA4, PKD1, PEPD, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and MAMDC4, PDIA4, IGFBP2, PKD1, DCXR and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and MAMDC4,FGA, SLAMF8, PEPD, HEG1 and SERPINA1, AREG, ADAM12, PDIA4, CD55 and DCXR, PDIA4, PEPD, FAP, DCXR and SERPINA1, ADAM12, MAMDC4, FAP, PRDX1 and TBCB, ADAM12, FGA, AGR3, IL1RAP and CEACAM5, PDIA4, PKD1, DCXR, IL1RAP and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MCAM, SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and MCAM, PDIA4, CEACAM5, DCXR, ALCAM and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and TBCB, ADAM12, PEPD, FAP, PRDX 1 and IL17RA, AREG, ADAM12, TNC, NCS1 and DCXR, PDIA4, CLEC3B, PKD1, DCXR and PEP D, AREG, FGA, HEG1, IL1RAP and PDIA4, SERPINA1, PKD1, SLAMF8, DCXR and AGR3, PD IA4, PRTN3, PEPD, FAP and TBCB, ADAM12, FAP, PRDX1, DCXR and PEPD, AREG, PDIA4, PKD1, DCXR and NCS1, PDIA4, PEPD, DCXR, IL1RAP and MCAM, AREG, TNC, MAMDC4, NCS1 and TBCB, PDIA4, PKD1, PRTN3, PEPD and ADAMTSL4, ADAM12, AGR3, MAMDC4, IL1RAP and CEACAM5, SERPINA1, AREG, FGA, HEG1 and MAMDC4, PDIA4, TBCB, PKD1, DCXR and ALCAM, PDIA4, TBCB, PEPD, FAP and TNC, CEACAM5, AGR3, HEG1, PRDX1 and ADA MTSL4, CEACAM5, AGR3, HEG1, PRDX1 and LRG1, ADAM12, FGA, MAMDC4, HEG1 and SE RPINA1, FGA, AGR3, SLAMF8, HEG1 and TNC, AREG, PDIA4, CEACAM5, HEG1 and MAMD C4, ADAM12, CEACAM5, FGA, HEG1 and IL17RA, AREG, MAMDC4, IL1RAP, PLXDC2 and TBCB,SERPINA1, CEACAM5, FGA, HEG1 and PDIA4, ADAM12, AGR3, MAMDC4, IL1RAP and FAP, ADAM12, PDIA4, PKD1, DCXR and PEPD, ADAM12, AGR3, MAMDC4, IL1RAP and MCA M, AREG, FGA, PEPD, HEG1 and TBCB, PDIA4, TNC, MCAM, DCXR and PEPD, ADAM12, FGA, AGR3, IL1RAP and MAMDC4, PDIA4, CEACAM5, DCXR, ALCAM and PRDX1, SERPINA1, AREG, FGA, HEG1 and IL17RA, AREG, TNC, PKD1, MAMDC4 and NCS1, TNC, AGR3, MAM DC4, IL1RAP and DCXR, TNC, AGR3, MAMDC4, IL1RAP and FAP, AREG, CEACAM5, FGA, HEG1 and PRDX1, CEACAM5, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PEPD, FAP, DCXR and CEACAM5, FGA, AGR3, SLAMF8, HEG1 and TBCB, AREG, FGA, PEPD, HEG1 and DCXR, PDIA4, PKD1, PEPD, DCXR and LRG1, CEACAM5, AGR3, SLAMF8, HEG1 and TNC, PDIA4, PEPD, FAP, DCXR and SLAMF8, ADAM12, FGA, MAMDC4, HEG1 and NCS1, AREG, FGA, PEP D, HEG1 and NCS1, ADAM12, FAP, PRDX1, DCXR and ALCAM, ADAM12, PEPD, FAP, PRDX 1 and MCAM, ADAM12, CEACAM5, FAP, PRDX1 and PEPD, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PEPD, SERPINA1, SLAMF8, DCXR, PLXD C2 and MAMDC4, SERPINA1, PDIA4, PKD1, DCXR and ALCAM, AREG, PKD1, DCXR, IL1RA P and PDIA4, CEACAM5, AGR3, SLAMF8, HEG1 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP and SERPINA1, PDIA4, DCXR, IL1RAP, ALCAM and MCAM, PDIA4, PEPD, DCXR, IL1RAP and CEACAM5,PDIA4, TBCB, PEPD, FAP and LRG1, ADAM12, AGR3, MAMDC4, IL1RAP and ITIH3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ALCAM, ADAM12, FGA, SLAMF8, NCS1 and ALCAM, ADAM12, TNC, AGR3, IL1RAP and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and MAMDC4, AREG, TNC, PKD1, MAMDC4 and PEPD, SERPINA1, CEACAM5, HEG1, IL1RAP and DCXR, PDIA4, ITIH3, PKD1, PEPD and MAMDC4, AREG, FGA, PEPD, HEG1 and MCAM, PDIA4, PRT N3, PEPD, FAP and LRG1, TNC, AGR3, MAMDC4, IL1RAP and PDIA4, SERPINA1, ADAM12, FAP, PRDX1 and DCXR, PDIA4, TBCB, PEPD, FAP and CEACAM5, ADAM12, FGA, MAMDC4, HEG1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and DCXR, SERPINA1, SLAMF8, PEPD, DC XR and FAP, PDIA4, CEACAM5, PKD1, DCXR and IL17RA, ADAM12, FGA, FAP, PRDX1 and AGR3, TNC, AGR3, MAMDC4, IL1RAP and LRG1, PDIA4, TBCB, PKD1, DCXR and NCS1, SERPINA1, AREG, PKD1, DCXR and PDIA4, AREG, ADAM12, PDIA4, CD55 and CLEC3B, PDIA4, TNC, PEPD, FAP and CEACAM5, ADAM12, LRG1, FAP, PRDX1 and IL17RA, FGA, TBCB, MA MDC4, HEG1 and TNC, PDIA4, CEACAM5, PEPD, HEG1 and ADAM12, PDIA4, TNC, ITIH3, PKD1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and MCAM, PDIA4, DCXR, IL1RAP, ALCA M and TBCB, CEACAM5, FGA, HEG1, PRDX1 and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and PEPD, PDIA4, PEPD, DCXR, IL1RAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and PEP D,ADAM12, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, FAP, DCXR, ALCAM and PRDX1, SERPINA1, TNC, DCXR, PLXDC2 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and AGR3, PDIA4, TBCB, PEPD, FAP and NCS1, ADAM12, FGA, AGR3, IL1RAP and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and FAP, PDIA4, FGA, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, SL AMF8, NCS1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and MAMDC4, AREG, ADAM12, FG A, HEG1 and ALCAM, ADAM12, PDIA4, PKD1, DCXR and ALCAM, SERPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB, FGA, AGR3, SLAMF 8, HEG1 and NCS1, PDIA4, PEPD, HEG1, FAP and SERPINA1, SERPINA1, TNC, DCXR, PLXD C2 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MCAM, SERPINA1, SLAMF8, DCXR, PLXDC2 and FAP, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and MAMDC4, PDIA4, IGFBP2, DCXR, AL CAM and IL17RA, ADAM12, TNC, FAP, PRDX1 and PEPD, PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA, CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12, SERPINA1, SLAMF8, PEPD, DCXR and NCS1, PDIA4, ADAMTSL4, PKD1, DCXR and FAP, FGA, AGR3, SLAMF8, HEG1 and DCXR, PDIA4, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and NCS1, CEA CAM5, TNC, FGA, HEG1 and NCS1, ADAM12, CLEC3B, AGR3, IL1RAP and TBCB, ADAM12, PEPD, FAP, PRDX1 and SERPINA1, ADAM12, FGA, AGR3, IL1RAP and IL17RA,SERPINA1, PDIA4, MAMDC4, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, ALCAM and FAP, SERPINA1, AREG, PKD1, DCXR and CEACAM5, PDIA4, FAP, DCXR, ALCAM and ITIH3, CEACAM5, AGR3, HEG1, PRDX1 and PDIA4, SERPINA1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4, IL17RA, DCXR, ALCAM and MAMDC4, PDIA4, FGA, PEPD, HEG1 and DCXR, ADAM12, LRG1 , FAP, PRDX1 and ALCAM, FGA, AGR3, SLAMF8, HEG1 and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and IGFBP2, SERPINA1, TBCB, SLAMF8, PLXDC2 and MCAM, PDIA4, PEPD, FAP, DCXR and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and MCAM, SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5, AREG, PKD1, DCXR, IL1RAP and NCS1, PDIA4, CEACAM5, PKD1, DC XR and TBCB, SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP, PDIA4, FGA, IGFBP2, PKD1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1 and PKD1, PDIA4, PEPD, HEG1, FAP and MAMDC4, PDIA4, IL17RA, DCXR, ALCAM and TNC, AREG, PKD1, DCXR, IL1RAP and MAMDC4, AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3, ADAM12, AGR3, MAMDC4, IL1RAP and PRDX1, SERPI NA1, PDIA4, CEACAM5, HEG1 and NCS1, ADAM12, CEACAM5, FAP, PRDX1, DCXR, ARE G, PKD1, DCXR, IL1RAP and ALCAM, PDIA4, FAP, DCXR, ALCAM and MAMDC4, PDIA4, PEPD, HEG1, FAP and LRG1, ADAM12, TBCB, FAP, PRDX1 and TNC, CEACAM5, SLAMF8, HE G1, DCXR and NCS1, CEACAM5, FGA, HEG1, PRDX1 and ALCAM,PDIA4, TNC, MCAM, DC XR and MAMDC4, FGA, CLEC3B, MAMDC4, HEG1 and PDIA4, AREG, TNC, PKD1, MAMDC4 and TBCB, AREG, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, MCAM, DCXR, ALCAM and PRDX1, ADAM12, FAP, PRDX1, DCXR and IL17RA, SERPINA1, CEACAM5, CLEC3B, PRDX1 and ALCAM, CEACAM5, FGA, PEPD, HEG1 and AGR3, PDIA4, CEACAM5, PEPD, HEG1 and SL AMF8, PDIA4, TBCB, PEPD, FAP and ALCAM, PDIA4, PEPD, FAP, DCXR and LRG1, AREG, ADAM12, PKD1, DCXR and NCS1, CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2, SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD, ADAM12, MAMDC4, FAP, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD, AREG , PDIA4, PKD1, DCXR and ADAMTSL4, CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B, AREG, ADAM12, FGA, HEG1 and AGR3, AREG, FGA, HEG1, IL1RAP and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and PEPD, AREG, PKD1, DCXR, IL1RAP and MCAM, PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4, AREG, ADAM12, PDIA4, CD55 and NCS1, ADAM12, FGA, AGR3, IL 1RAP and TNC, SERPINA1, PEPD, IL1RAP, PLXDC2 and LRG1, AREG, PKD1, DCXR, IL1RAP and PEPD, TNC, AGR3, MAMDC4, IL1RAP and CEACAM5, AREG, TNC, MAMDC4, NCS1 and DCXR, AREG, PKD1, SLAMF8, DCXR and NCS1, AREG, TNC, MAMDC4, NCS1 and ALCAM, PDIA4, PRTN3, PEPD, FAP and ADAMTSL4, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB,CEACAM5, AGR3, SLAMF8, HEG1 and SERPINA1, PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B, ADAM12, FGA, FAP, PRDX1 and PEPD, TNC, CLEC3B, AGR3, IL1RAP and ADAMTSL4, CEACAM5, AGR3, SLAMF8, HEG1 and ALCAM, ADAM12, CEACAM5, FAP, PRDX1 and PDIA4, AREG, PDIA4, DCXR, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and TNC, SERPINA1, P EPD, IL1RAP, PLXDC2 and MAMDC4, AREG, PKD1, SLAMF8, DCXR and TBCB, FGA, AGR3, SLAMF8, HEG1 and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4, ADAM12, FGA, AGR3, IL1RAP and ALCAM, PDIA4, PRTN3, PEPD, FAP and SERPINA1, ADAM12, CLEC3B, AGR3, IL1RAP and NCS1, SERPINA1, PKD1, SLAMF8, DCXR and TBCB, ADAM12, MAMDC4, F AP, PRDX1 and ADAMTSL4, TNC, CLEC3B, AGR3, IL1RAP and PRDX1, AREG, PKD1, DCXR, IL1RAP and TNC, FGA, AGR3, SLAMF8, HEG1 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and DCXR, AREG, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and FGA, ADAM12, FGA, FAP, P RDX1 and NCS1, SERPINA1, AREG, IL1RAP, PLXDC2 and AGR3, PDIA4, CEACAM5, MEGF9, PEPD and ADAM12, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and NCS1, PDIA4, PEPD, DCXR, IL1RAP and ALCAM, SERPINA1, SLAMF8, PEPD, DCXR and MAMDC4, AREG, TNC, PKD1, MAMDC4 and FAP, PDIA4, PKD1, PEPD, DCXR and ADAMTSL4, PDIA4, MCAM, DCXR, ALCAM and CEACAM5,SERPINA1, CEACAM5, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ALCAM, PDIA4, FGA, PKD1, DCXR and PEPD, SERPINA1, PDIA4, PKD1, DCXR and MAMDC4, AREG, ADAM12, HEG1, IL1RAP and PDIA4, AREG, FGA, HEG1, IL1RAP and NCS1, ADAM12, TNC, AGR3, IL1RAP and SERPINA1, CEAC AM5, ADAMTSL4, SLAMF8, HEG1 and PDIA4, AREG, ADAM12, PKD1, DCXR and PRDX1, ADAM12, TNC, AGR3, IL1RAP and ITIH3, CEACAM5, FGA, PEPD, HEG1 and TNC, PDIA4, ADAMTSL4, PKD1, DCXR and NCS1, FGA, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PKD1, PEPD, DCXR and ALCAM, PDIA4, TNC, IGFB P2, MCAM and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CEACAM5, AREG, CEACAM5, HEG1, IL1RAP and PRDX1, ADAM12, CEACAM5, FAP, PRDX1 and ITIH3, PDIA4, TBCB, PKD 1, DCXR and ITIH3, AREG, TBCB, PKD1, DCXR and TNC, SERPINA1, SLAMF8, PEPD, DCXR and PDIA4, PDIA4, TNC, PEPD, FAP and CLEC3B, AREG, MAMDC4, IL1RAP, PLXDC2 and CLE C3B, PDIA4, TBCB, PKD1, DCXR and IL17RA, CEACAM5, FGA, PEPD, HEG1 and ADAM12, TNC, AGR3, MAMDC4, IL1RAP and PKD1, PDIA4, TNC, MCAM, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and MCAM, PDIA4, TNC, MAMDC4, CD55 and DCXR, AREG, PDIA4, DCXR, ALCAM and PEPD, AREG, TNC, MAMDC4, NCS1 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and IL17RA, ADAM12, FGA, MAMDC4, HEG1 and PEPD, AREG, FGA, HEG1, IL1RAP and DCX R,ADAM12, FGA, AGR3, IL1RAP and PEPD, PDIA4, CEACAM5, PKD1, DCXR and NCS1, CE ACAM5, ADAMTSL4, HEG1, PRDX1 and IGFBP2, ADAM12, MAMDC4, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, PKD1, DCXR and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CLEC3B, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, AREG, ADAM12, HEG1, IL1RAP and DCXR. C2 and NCS1, ADAM12, PDIA4, CD55, FAP and AGR3, PDIA4, TBCB, PEPD, FAP and PRDX1, ADAM12, LRG1, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8, PDIA4, PKD1, DCXR, IL1RAP and FAP, AREG, FGA, PEPD, HEG1 and ADAMTSL4, SERPINA1, TNC, DCXR, PLXDC2 and PDIA4, SERPINA1, MEGF 9. PRTN3, IL1RAP and AGR3, PDIA4, IGFBP2, PKD1, DCXR and IL17RA, SERPINA1, PDIA4, PKD1, DCXR and NCS1, PDIA4, TNC, MCAM, DCXR and NCS1, PDIA4, IGFBP2, PKD1, DCXR and ALCAM, PDIA4, PEPD, DCXR, IL1RAP and FAP, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1, PDIA4, FAP, DCXR, ALCAM and TBCB, AREG, CEACAM5, HEG1, IL1RAP and AGR 3, PDIA4, TNC, ITIH3, PKD1 and TBCB, SERPINA1, AREG, IL1RAP, PLXDC2 and TNC, ADAM12, DCXR, IL1RAP, ALCAM and MAMDC4, PDIA4, TBCB, PEPD, FAP and AGR3, PDIA4, FGA, IGFBP2, PKD1 and ITIH3, AREG, TNC, PKD1, MAMDC4 and ALCAM, ADAM12, CEACA M5, DCXR, IL1RAP and SERPINA1, AREG, MAMDC4, IL1RAP, PLXDC2 and MCAM,SERPINA 1, CEACAM5, CLEC3B, PRDX1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and ALCAM, PDIA4, PEPD, HEG1, FAP and CEACAM5, AREG, ADAM12, TNC, NCS1 and PRDX1, CEACAM5, FGA, PEPD, HEG1 and DCXR, AREG, TBCB, PKD1, DCXR and NCS1, SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and TBCB, ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4.

4. CD55 and AGR3, PDIA4, PKD1, DCXR, IL1RAP and ADAMTSL4, ADAM12, PDIA4, CD55, FAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and TBCB, SERPINA1, PDIA4, MAMDC4, PLXD C2 and PEPD, PDIA4, FAP, DCXR, ALCAM and NCS1, PDIA4, IL17RA, DCXR, ALCAM and NCS 1, SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR, SERPINA1, CEACAM5, CLEC3B, PRDX1 and PDIA4, PDIA4, PEPD, DCXR, IL1RAP and PRDX1, SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD, ADAM12, PDIA4, DCXR, ALCAM and AGR3, CEACAM5, AGR3, SLAMF8, HEG1 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and ALCAM, AREG, TBCB, PKD1, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCA M, SERPINA1, AREG, PKD1, DCXR and ALCAM, AREG, ADAM12, PKD1, DCXR and ALCAM, AREG, PDIA4, DCXR, ALCAM and AGR3, ADAM12, PDIA4, CD55, FAP and PRDX1,SERPINA 1, SLAMF8, DCXR, PLXDC2 and TNC, ADAM12, PDIA4, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and DCXR, SER PINA1, MEGF9, PRTN3, IL1RAP and TNC, CEACAM5, FGA, HEG1, PRDX1 and PEPD, PDIA4, PEPD, FAP, DCXR and TNC, PDIA4, FGA, IGFBP2, PKD1 and TBCB, SERPINA1, PDIA4, CEA CAM5, HEG1 and ADAM12, AREG, ADAM12, HEG1, IL1RAP and ITIH3, ADAM12, PDIA4, DCXR, ALCAM and IGFBP2, AREG, PDIA4, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL 1RAP and MAMDC4, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and PRDX1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and LRG1, SERPINA1, PDI A4, MAMDC4, PLXDC2 and AGR3, SERPINA1, PDIA4, MAMDC4, PLXDC2 and TBCB, AREG, ADAM12, IL1RAP, PLXDC2 and DCXR, SERPINA1, AREG, FGA, HEG1 and PEPD, SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM, SERPINA1, PDIA4, PKD1, DCXR and AGR3, ADAM12, MAMDC4, FAP, PRDX1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4, PDIA4, CE ACAM5, MEGF9, PEPD and AGR3, PDIA4, ITIH3, PEPD, FAP and IL17RA, SERPINA1, AREG, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and ALCAM, CEACAM5, FGA, PEP D, HEG1 and IGFBP2, PDIA4, CEACAM5, PEPD, HEG1 and TBCB, PDIA4, FGA, PKD1, DCXR and MAMDC4, PDIA4, CEACAM5, PKD1, DCXR and PEPD,ADAM12, DCXR, IL1RAP, ALCA M and CEACAM5, SERPINA1, AREG, IL1RAP, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, AL CAM and CLEC3B, SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1, ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2, CEACAM5, TNC, FGA, HEG1 and MAMDC4, SERPINA1, TNC, DCXR, PL XDC2 and FAP, AREG, CEACAM5, FGA, HEG1 and MEGF9, FGA, AGR3, SLAMF8, HEG1 and FAP, SERPINA1, SLAMF8, DCXR, PLXDC2 and ALCAM, SERPINA1, PKD1, SLAMF8, DCXR and PDIA4, ADAM12, TBCB, FAP, PRDX1 and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and ALCA M, PDIA4, MCAM, DCXR, ALCAM and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and IL17RA, SERPINA1, AREG, IL1RAP, PLXDC2 and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and ALCAM, PDIA4, TBCB, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and PEPD, PDIA4, CEACA M5, PKD1, DCXR and TNC, SERPINA1, SLAMF8, PEPD, DCXR and ADAMTSL4, AREG, TNC, PKD1, MAMDC4 and DCXR, PDIA4, CEACAM5, DCXR, ALCAM and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and ALCAM, AREG, PKD1, DCXR, IL1RAP and TBCB, P DIA4, TNC, MAMDC4, CD55 and ADAM12, PDIA4, PKD1, PRTN3, PEPD and TBCB, ADAM12, FGA, MAMDC4, HEG1 and FAP, PDIA4, PKD1, PRTN3, PEPD and AGR3, PDIA4, CLEC3B, PKD1, DCXR and MAMDC4, SERPINA1, HEG1, IL1RAP, PLXDC2 and PEPD, ADAM12, PDIA4, PKD1, DCXR and NCS1,FGA, SLAMF8, PEPD, HEG1 and ALCAM, SE RPINA1, AREG, IL1RAP, PLXDC2 and TBCB, PDIA4, TBCB, PKD1, DCXR and LRG1, PDIA4, PEPD, DCXR, IL1RAP and NCS1, SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1, ADAM12, FGA, AGR3, IL1RAP and DCXR, AREG, ADAM12, PKD1, DCXR and IL17RA, ADAM12, CEACAM5, DCXR, IL1RAP and FGA, TNC, CLEC3B, AGR3, IL1RAP and FAP, FGA, CLEC3B, MAMDC 4. HEG1 and AGR3, AREG, MAMDC4, IL1RAP, PLXDC2 and DCXR, CEACAM5, FGA, PEPD, HEG1 and TBCB, AREG, ADAM12, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ITIH3, AREG, PDIA4, CEACAM5, HEG1 and PEPD, PDIA4, ITIH3, PKD1, PEPD and DCXR, CE ACAM5, AGR3, HEG1, PRDX1 and SERPINA1, ADAM12, AGR3, MAMDC4, IL1RAP and DCXR, AREG, TBCB, PKD1, DCXR and ADAMTSL4, SERPINA1, PKD1, SLAMF8, DCXR and ALCAM, ADAM12, FGA, SLAMF8, NCS1 and IL17RA, PDIA4, PKD1, PEPD, DCXR and MCAM, CEACA M5, AGR3, HEG1, PRDX1 and CLEC3B, AREG, TBCB, PKD1, DCXR and AGR3, PDIA4, PRTN 3, PEPD, FAP and IL17RA, PDIA4, SLAMF8, MCAM, DCXR and PRDX1, FGA, AGR3, SLAMF 8. HEG1 and PDIA4, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL4, PDIA4, FAP, DCXR, ALCAM and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and CLEC3B, PDIA4, ADAMTSL4, PKD1, DCXR and SERPINA1, PDIA4, PKD1, DCXR, IL1RAP and IL17RA,ADAM12, TNC, FAP, PRDX1 and NCS1, SERPINA1, SLAMF8, DCXR, PLX DC2 and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5, ADAM12, CEACAM5, DCXR, IL1RAP and LRG1, ADAM12, FGA, SLAMF8, NCS1 and SERPINA1, ADAM12, PDIA4, CD55, FAP and IL17RA, SERPINA1, PEPD, IL1RAP, PLXDC2 and MCAM, PDIA4, PEPD, DCXR, IL1RA P and MAMDC4, PDIA4, PEPD, DCXR, IL1RAP and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and LRG1, AREG, PDIA4, CEACAM5, HEG1 and NCS1, PDIA4, TNC, MCAM, DCXR and PRDX1, PDIA4, CEACAM5, PEPD, HEG1 and PRDX1, SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2, PDIA4, ITIH3, PEPD, FAP and ALCAM, CEACAM5, AGR3, SLAMF8, HEG1 and LR G1, PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and DCXR, FGA, SLAMF8, PEPD, HEG1 and CLEC3B, ADAM12, DCXR, IL1RAP, ALCAM and ITIH3, AREG, ADAM12, PKD1, DCXR and MCAM, PDIA4, SLAMF8, MCAM, DCXR and FAP, ADAM12, TNC, AGR3, IL1RAP and TBCB, PDIA4, SLAMF8, MCAM, DCXR and SERPINA1, PDIA4, FGA, PKD1, DCXR and TBCB, PDIA4, FGA, PEPD, HEG1 and TNC, CEACAM5, ADAM TSL4, HEG1, PRDX1 and MAMDC4, ADAM12, MAMDC4, FAP, PRDX1 and CLEC3B, PDIA4, PKD1, PRTN3, PEPD and NCS1, PDIA4, TBCB, PKD1, DCXR and ADAM12, ADAM12, CEACAM 5, FGA, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PDIA4, CEACAM5, FGA, HEG1, PRDX1 and SERPINA1,CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4, PDIA4, TNC, MA MDC4, CD55 and NCS1, ADAM12, PEPD, FAP, PRDX1 and PDIA4, FGA, SLAMF8, PEPD, HE G1 and TNC, AREG, PDIA4, PKD1, DCXR and CEACAM5, SERPINA1, AREG, PKD1, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and TNC, ADAM12, FGA, AGR3, IL1RAP and CLEC3B, PDIA4, IGFBP2, DCXR, ALCAM and TNC, AREG, ADAM12, HEG1, IL1RAP and PRDX1, PDIA4, C EACAM5, MEGF9, PEPD and NCS1, ADAM12, PDIA4, DCXR, ALCAM and IL17RA, SERPINA1, ADAM12, FAP, PRDX1 and TBCB, PDIA4, CEACAM5, PKD1, DCXR and FGA, AREG, ADAM12, IL1RAP, PLXDC2 and PDIA4, PDIA4, FGA, PKD1, DCXR and ASPN, CEACAM5, ADAMTSL 4, HEG1, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PDIA4, AREG, TNC, MAMDC4, NCS1 and ITIH3, SERPINA1, AREG, FGA, HEG1 and PDIA4, PDIA4, CEACAM5, PEPD, HEG1 and NCS1, CEACAM5, SLAMF8, PEPD, HEG1 and IGFBP2, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and PEPD, PDIA4, PEPD, FAP, DCXR and NCS1, TNC, CLEC3B, AGR3, IL1RAP and CE ACAM5, SERPINA1, ADAM12, FAP, PRDX1 and PDIA4, PDIA4, PKD1, PRTN3, PEPD and PRD X1, SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8, ADAM12, FGA, AGR3, IL1RAP and PR DX1, PDIA4, ITIH3, PEPD, FAP and CEACAM5, CEACAM5, FGA, HEG1, PRDX1 and IL17RA,ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and IGFBP2, ADAM12, PDIA4, CD55, FAP and MAMDC4, AREG, ADAM12, PKD1, DCXR and CLEC3B, SER PINA1, PKD1, SLAMF8, DCXR and LRG1, CEACAM5, SLAMF8, PEPD, HEG1 and TNC, AREG, TNC, MAMDC4, NCS1 and MCAM, TNC, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, LRG1, FAP, PRDX1 and DCXR, PDIA4, ADAMTSL4, PKD1, DCXR and AGR3, AREG, TNC, PKD1, MAMDC4 and IGFBP2, ADAM12, TBCB, FAP, PRDX1 and DCXR, AREG, PDIA4, PKD1, DCXR and ALCAM, FGA, TBCB, MAMDC4, HEG1 and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and PD IA4, SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM, PDIA4, ITIH3, PKD1, PEPD and IGFBP2, PDIA4, PEPD, DCXR, IL1RAP and ADAMTSL4, AREG, MAMDC4, IL1RAP, PLXDC2 and ALCA M, ADAM12, DCXR, IL1RAP, ALCAM and ADAMTSL4, PDIA4, CEACAM5, DCXR, ALCAM and NCS1, ADAM12, CEACAM5, DCXR, IL1RAP and PRDX1, CEACAM5, SLAMF8, HEG1, DC XR and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ITIH3. XDC2 and ALCAM, ADAM12, FGA, FAP, PRDX1 and PDIA4, PDIA4, TNC, MAMDC4, CD55 and TBCB, AREG, FGA, PEPD, HEG1 and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and LRG1, AD AM12, PDIA4, DCXR, ALCAM and MCAM, CEACAM5, SLAMF8, HEG1, DCXR and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and MCAM, ADAM12, TNC, FAP, PRDX1 and IGFBP2,ADA M12, SLAMF8, DCXR, IL1RAP and MAMDC4, AREG, PDIA4, DCXR, ALCAM and ADAM12, AREG, TBCB, PKD1, DCXR and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and PEPD, AREG, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, TBCB, PEPD, FAP and ADAMTSL4, SERPINA1, CLEC3B, IL1RAP, PLXDC2 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and NCS1, AREG, MAMD C4, IL1RAP, PLXDC2 and PDIA4, SERPINA1, TNC, DCXR, PLXDC2 and AGR3, ADAM12, CLE C3B, AGR3, IL1RAP and CEACAM5, PDIA4, FGA, PKD1, DCXR and ADAMTSL4, PDIA4, ITIH 3. PKD1, PEPD and FAP, PDIA4, FGA, PKD1, DCXR and LRG1, PDIA4, CEACAM5, MEGF9, PEPD and ALCAM, ADAM12, FGA, MAMDC4, HEG1 and TNC, CEACAM5, FGA, HEG1, PRDX1 and PDIA4, ADAM12, CEACAM5, FAP, PRDX1 and ADAMTSL4, PDIA4, TNC, MCAM, DCXR and CLEC3B, PDIA4, TNC, MAMDC4, CD55 and FGA, AREG, FGA, HEG1, IL1RAP and FAP, CEACAM5, FGA, PEPD, HEG1 and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3, PDI A4, PKD1, PRTN3, PEPD and MAMDC4, PDIA4, TNC, PEPD, FAP and ALCAM, AREG, FGA, PEPD, HEG1 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and ALCAM, SERPINA1, CEAC AM5, FGA, HEG1 and ASPN, SERPINA1, CEACAM5, CLEC3B, PRDX1 and MAMDC4, ADAM12, FGA, FAP, PRDX1 and IL17RA, PDIA4, FGA, PKD1, DCXR and NCS1, AREG, MAMDC4, IL1RAP, PLXDC2 and TNC, PDIA4, DCXR, IL1RAP, ALCAM and MAMDC4,SERPINA1, CEACAM5, FGA, HEG1 and AGR3, PDIA4, SLAMF8, MCAM, DCXR and AGR3, AREG, ADAM12, PKD1, DCXR and SERPINA1, PDIA4, IGFBP2, CD55, MCAM and DCXR, PDIA4, FGA, PKD1, DCXR and ALCAM, PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4, PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4, PDIA4, IGFBP2, PKD1, DCXR and LRG1, PDIA4, CEACAM5, PKD1, DCXR and LRG1, AREG, ADAM12, PKD1, DCXR and CEACAM5, ADAM12, DCXR, IL1RAP, ALCAM and PR DX1, ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4, PDIA4, PEPD, FAP, DCXR and AGR 3, TNC, AGR3, MAMDC4, IL1RAP and TBCB, ADAM12, PDIA4, DCXR, ALCAM and ADAMTS L4, CEACAM5, FGA, PEPD, HEG1 and NCS1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and ALC AM, AREG, PDIA4, CEACAM5, HEG1 and PRDX1, ADAM12, TBCB, FAP, PRDX1 and CLEC3B, PDIA4, PEPD, HEG1, FAP and PRDX1, TNC, AGR3, MAMDC4, IL1RAP and PEPD, ADAM12, CEACAM5, FGA, HEG1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and TBCB, CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA, PDIA4, FGA, PEPD, HEG1 and TBCB, ADAM12, FGA, SLA MF8, NCS1 and ITIH3, AREG, TBCB, PKD1, DCXR and PDIA4, PDIA4, PKD1, PRTN3, PEPD and DCXR, PDIA4, PEPD, FAP, DCXR and CLEC3B, PDIA4, SLAMF8, MCAM, DCXR and MAMDC4, AREG, PDIA4, DCXR, ALCAM and TBCB, SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3, SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4,ADAM12, PDIA4, DCXR, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1 and MAMDC4, AREG, PKD1, DCXR, IL1RAP and FAP, ADAM12, PDIA4, PKD1, DCXR and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and AGR3, PDIA4, TNC, ITIH3, PKD1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and IL17RA, FGA, TBCB, MAMDC 4, HEG1 and AGR3, PDIA4, TNC, PEPD, FAP and AGR3, SERPINA1, AREG, PKD1, DCXR and ADAMTSL4, FGA, AGR3, SLAMF8, HEG1 and SERPINA1,PDIA4TBCB, PKD1, DCXR and PEPD, PDIA4, TBCB, PEPD, FAP and DCXR, SERPINA1, PDIA4, PKD1, DCXR and PEPD, ADAM12, TNC, AGR3, IL1RAP and MAMDC4, ADAM12, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, TBCB, FAP, PRDX1 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and ADAM12, TNC, CLEC3B, AGR3, IL1RAP and MAMDC4, CEACAM5, ADAMTSL4, HEG1, PRDX1 and AGR3, PDIA4, DCXR, IL1RAP, ALCAM and PEPD, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PEPD, CEACAM5, AGR3, SLAMF8, HEG1 and FGA, PDIA4, TBCB, PKD1, DCXR and CEACAM5, PDIA4, TNC, PEPD, FAP and TBCB, ADAM12, PDIA4, PKD1, DCXR and TBCB, ADAM12, PEPD, FAP, PRDX1 and DCXR, PDIA4, TNC, PEPD, FAP and DCXR, PDIA4, PKD1, PEPD, DCXR and CEACAM5, AREG, MAMDC4, IL1RAP, PLXDC2 and SERPINA1, CEACAM5, SLAMF8, HEG1, DCXR and ADAMTSL4, TNC, AGR3, MAMDC 4. IL1RAP and ADAM12, ADAM12, MAMDC4, FAP, PRDX1 and PEPD, ADAM12, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, CEACAM5, PEPD, HEG1 and FAP, or CEACAM5, TNC, FGA, HE G1 and PEPD; Preferably, the 5 markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC, PDIA4, PKD 1, PEPD, DCXR and TBCB, CEACAM5, TNC, FGA, HEG1 and DCXR, PDIA4, PEPD, DCXR, IL1RAP and TNC, CEACAM5, FGA, PEPD, HEG1 and SERPINA1, ADAM12, PEPD, FAP, PRDX1 and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC, PDIA4, PRTN3, PEPD, FAP and DCXR, SERPINA1, ADAM12, IL1RAP, PLXDC2 and TBCB, ADAM12, PDIA4, DCXR, ALCAM and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and LRG1, CEACAM5, ADAMTSL4, HEG1, PR DX1 and PDIA4, PDIA4, PKD1, PEPD, DCXR and MAMDC4, SERPINA1, AREG, IL1RAP, PLXD C2 and MAMDC4, PDIA4, PEPD, FAP, DCXR and MCAM, TNC, AGR3, MAMDC4, IL1RAP and CLEC3B, ADAM12, AGR3, MAMDC4, IL1RAP and SERPINA1, AREG, ADAM12, TNC, NCS1 and PEPD, PDIA4, PEPD, HEG1, FAP and TNC, PDIA4, PKD1, PEPD, DCXR and FAP, SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4, PDIA4, PEPD, FAP, DCXR and TBCB, SERPINA1, CE ACAM5, FGA, HEG1 and MAMDC4, PDIA4, PKD1, PRTN3, PEPD and TNC, SERPINA1, MAMD C4, IL1RAP, PLXDC2 and ADAMTSL4, ADAM12, MAMDC4, FAP, PRDX1 and NCS1, ADAM12, AGR3, MAMDC4, IL1RAP and NCS1, PDIA4, PEPD, HEG1, FAP and DCXR, CEACAM5, SLAMF 8, PEPD, HEG1 and ADAM12, AREG, PDIA4, DCXR, ALCAM and MAMDC4, PDIA4, PKD1, DCXR, IL1RAP and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and MAMDC4,PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, MAMDC4, HEG1 and TBCB, AREG, PDIA4, PK D1, DCXR and MAMDC4, AREG, PDIA4, PKD1, DCXR and TNC, CEACAM5, AGR3, HEG1, PRDX1 and SLAMF8, PDIA4, PKD1, PEPD, DCXR and SERPINA1, ADAM12, DCXR, IL1RAP, AL CAM and TNC, CEACAM5, AGR3, SLAMF8, HEG1 and TBCB, PDIA4, ADAMTSL4, PKD1, DC XR and MAMDC4, PDIA4, CEACAM5, MEGF9, PEPD and DCXR, PDIA4, FAP, DCXR, ALCAM and PEPD, TNC, AGR3, MAMDC4, IL1RAP and ALCAM, AREG, PKD1, SLAMF8, DCXR and IGF BP2, TNC, AGR3, MAMDC4, IL1RAP and MCAM, ADAM12, AGR3, MAMDC4, IL1RAP and SL AMF8, ADAM12, PDIA4, DCXR, ALCAM and CLEC3B, PDIA4, IL17RA, DCXR, ALCAM and AGR3, PDIA4, MCAM, DCXR, ALCAM and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and DC XR, SERPINA1, HEG1, IL1RAP, PLXDC2 and DCXR, PDIA4, TNC, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and CEACAM5, SERPINA1, PDIA4, PKD1, DCXR and TBCB, SERPIN A1, ADAM12, IL1RAP, PLXDC2 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and TNC, ADAM12, FGA, MAMDC4, HEG1, ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and TNC, AREG, MAMDC4, IL1RAP, PLXDC2 and FAP, TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4, PDIA4, PKD1, PEPD, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and MAMDC4, PDIA4, IGFBP2, PKD1, DCXR and MAMDC4, CEACAM5, AGR3, HEG1, PRDX1 and MAMDC4,FGA, SLAMF8, PEPD, HEG1 and SERPINA1, AREG, ADAM12, PDIA4, CD55 and DCXR, PDIA4, PEPD, FAP, DCXR and SERPINA1, ADAM12, MAMDC4, FAP, PRDX1 and TBCB, ADAM12, FGA, AGR3, IL1RAP and CEACAM5, PDIA4, PKD1, DCXR, IL1RAP and TNC, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MCAM, SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and MCAM, PDIA4, CEACAM5, DCXR, ALCAM and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and TBCB, ADAM12, PEPD, FAP, PRDX 1 and IL17RA, AREG, ADAM12, TNC, NCS1 and DCXR, PDIA4, CLEC3B, PKD1, DCXR and PEP D, AREG, FGA, HEG1, IL1RAP and PDIA4, SERPINA1, PKD1, SLAMF8, DCXR and AGR3, PD IA4, PRTN3, PEPD, FAP and TBCB, ADAM12, FAP, PRDX1, DCXR and PEPD, AREG, PDIA4, PKD1, DCXR and NCS1, PDIA4, PEPD, DCXR, IL1RAP and MCAM, AREG, TNC, MAMDC4, NCS1 and TBCB, PDIA4, PKD1, PRTN3, PEPD and ADAMTSL4, ADAM12, AGR3, MAMDC4, IL1RAP and CEACAM5, SERPINA1, AREG, FGA, HEG1 and MAMDC4, PDIA4, TBCB, PKD1, DCXR and ALCAM, PDIA4, TBCB, PEPD, FAP and TNC, CEACAM5, AGR3, HEG1, PRDX1 and ADA MTSL4, CEACAM5, AGR3, HEG1, PRDX1 and LRG1, ADAM12, FGA, MAMDC4, HEG1 and SE RPINA1, FGA, AGR3, SLAMF8, HEG1 and TNC, AREG, PDIA4, CEACAM5, HEG1 and MAMD C4, ADAM12, CEACAM5, FGA, HEG1 and IL17RA, AREG, MAMDC4, IL1RAP, PLXDC2 and TBCB,SERPINA1, CEACAM5, FGA, HEG1 and PDIA4, ADAM12, AGR3, MAMDC4, IL1RAP and FAP, ADAM12, PDIA4, PKD1, DCXR and PEPD, ADAM12, AGR3, MAMDC4, IL1RAP and MCA M, AREG, FGA, PEPD, HEG1 and TBCB, PDIA4, TNC, MCAM, DCXR and PEPD, ADAM12, FGA, AGR3, IL1RAP and MAMDC4, PDIA4, CEACAM5, DCXR, ALCAM and PRDX1, SERPINA1, AREG, FGA, HEG1 and IL17RA, AREG, TNC, PKD1, MAMDC4 and NCS1, TNC, AGR3, MAM DC4, IL1RAP and DCXR, TNC, AGR3, MAMDC4, IL1RAP and FAP, AREG, CEACAM5, FGA, HEG1 and PRDX1, CEACAM5, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PEPD, FAP, DCXR and CEACAM5, FGA, AGR3, SLAMF8, HEG1 and TBCB, AREG, FGA, PEPD, HEG1 and DCXR, PDIA4, PKD1, PEPD, DCXR and LRG1, CEACAM5, AGR3, SLAMF8, HEG1 and TNC, PDIA4, PEPD, FAP, DCXR and SLAMF8, ADAM12, FGA, MAMDC4, HEG1 and NCS1, AREG, FGA, PEP D, HEG1 and NCS1, ADAM12, FAP, PRDX1, DCXR and ALCAM, ADAM12, PEPD, FAP, PRDX 1 and MCAM, ADAM12, CEACAM5, FAP, PRDX1 and PEPD, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PEPD, SERPINA1, SLAMF8, DCXR, PLXD C2 and MAMDC4, SERPINA1, PDIA4, PKD1, DCXR and ALCAM, AREG, PKD1, DCXR, IL1RA P and PDIA4, CEACAM5, AGR3, SLAMF8, HEG1 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP and SERPINA1, PDIA4, DCXR, IL1RAP, ALCAM and MCAM, PDIA4, PEPD, DCXR, IL1RAP and CEACAM5,PDIA4, TBCB, PEPD, FAP and LRG1, ADAM12, AGR3, MAMDC4, IL1RAP and ITIH3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ALCAM, ADAM12, FGA, SLAMF8, NCS1 and ALCAM, ADAM12, TNC, AGR3, IL1RAP and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and MAMDC4, AREG, TNC, PKD1, MAMDC4 and PEPD, SERPINA1, CEACAM5, HEG1, IL1RAP and DCXR, PDIA4, ITIH3, PKD1, PEPD and MAMDC4, AREG, FGA, PEPD, HEG1 and MCAM, PDIA4, PRT N3, PEPD, FAP and LRG1, TNC, AGR3, MAMDC4, IL1RAP and PDIA4, SERPINA1, ADAM12, FAP, PRDX1 and DCXR, PDIA4, TBCB, PEPD, FAP and CEACAM5, ADAM12, FGA, MAMDC4, HEG1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and DCXR, SERPINA1, SLAMF8, PEPD, DC XR and FAP, PDIA4, CEACAM5, PKD1, DCXR and IL17RA, ADAM12, FGA, FAP, PRDX1 and AGR3, TNC, AGR3, MAMDC4, IL1RAP and LRG1, PDIA4, TBCB, PKD1, DCXR and NCS1, SERPINA1, AREG, PKD1, DCXR and PDIA4, AREG, ADAM12, PDIA4, CD55 and CLEC3B, PDIA4, TNC, PEPD, FAP and CEACAM5, ADAM12, LRG1, FAP, PRDX1 and IL17RA, FGA, TBCB, MA MDC4, HEG1 and TNC, PDIA4, CEACAM5, PEPD, HEG1 and ADAM12, PDIA4, TNC, ITIH3, PKD1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and MCAM, PDIA4, DCXR, IL1RAP, ALCA M and TBCB, CEACAM5, FGA, HEG1, PRDX1 and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and PEPD, PDIA4, PEPD, DCXR, IL1RAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and PEP D,ADAM12, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, FAP, DCXR, ALCAM and PRDX1, SERPINA1, TNC, DCXR, PLXDC2 and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP and AGR3, PDIA4, TBCB, PEPD, FAP and NCS1, ADAM12, FGA, AGR3, IL1RAP and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and FAP, PDIA4, FGA, PEPD, HEG1 and ADAMTSL4, ADAM12, FGA, SL AMF8, NCS1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and MAMDC4, AREG, ADAM12, FG A, HEG1 and ALCAM, ADAM12, PDIA4, PKD1, DCXR and ALCAM, SERPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB, FGA, AGR3, SLAMF 8, HEG1 and NCS1, PDIA4, PEPD, HEG1, FAP and SERPINA1, SERPINA1, TNC, DCXR, PLXD C2 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MCAM, SERPINA1, SLAMF8, DCXR, PLXDC2 and FAP, CEACAM5, ADAMTSL4, SLAMF8, HEG1 and MAMDC4, PDIA4, IGFBP2, DCXR, AL CAM and IL17RA, ADAM12, TNC, FAP, PRDX1 and PEPD, PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA, CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12, SERPINA1, SLAMF8, PEPD, DCXR and NCS1, PDIA4, ADAMTSL4, PKD1, DCXR and FAP, FGA, AGR3, SLAMF8, HEG1 and DCXR, PDIA4, DCXR, IL1RAP, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and NCS1, CEA CAM5, TNC, FGA, HEG1 and NCS1, ADAM12, CLEC3B, AGR3, IL1RAP and TBCB, ADAM12, PEPD, FAP, PRDX1 and SERPINA1, ADAM12, FGA, AGR3, IL1RAP and IL17RA,SERPINA1, PDIA4, MAMDC4, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, ALCAM and FAP, SERPINA1, AREG, PKD1, DCXR and CEACAM5, PDIA4, FAP, DCXR, ALCAM and ITIH3, CEACAM5, AGR3, HEG1, PRDX1 and PDIA4, SERPINA1, PDIA4, CEACAM5, HEG1 and ALCAM, PDIA4, IL17RA, DCXR, ALCAM and MAMDC4, PDIA4, FGA, PEPD, HEG1 and DCXR, ADAM12, LRG1 , FAP, PRDX1 and ALCAM, FGA, AGR3, SLAMF8, HEG1 and CEACAM5, SERPINA1, ADAM12, FAP, PRDX1 and IGFBP2, SERPINA1, TBCB, SLAMF8, PLXDC2 and MCAM, PDIA4, PEPD, FAP, DCXR and ADAMTSL4, CEACAM5, AGR3, HEG1, PRDX1 and MCAM, SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5, AREG, PKD1, DCXR, IL1RAP and NCS1, PDIA4, CEACAM5, PKD1, DC XR and TBCB, SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP, PDIA4, FGA, IGFBP2, PKD1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1 and PKD1, PDIA4, PEPD, HEG1, FAP and MAMDC4, PDIA4, IL17RA, DCXR, ALCAM and TNC, AREG, PKD1, DCXR, IL1RAP and MAMDC4, AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3, ADAM12, AGR3, MAMDC4, IL1RAP and PRDX1, SERPI NA1, PDIA4, CEACAM5, HEG1 and NCS1, ADAM12, CEACAM5, FAP, PRDX1, DCXR, ARE G, PKD1, DCXR, IL1RAP and ALCAM, PDIA4, FAP, DCXR, ALCAM and MAMDC4, PDIA4, PEPD, HEG1, FAP and LRG1, ADAM12, TBCB, FAP, PRDX1 and TNC, CEACAM5, SLAMF8, HE G1, DCXR and NCS1, CEACAM5, FGA, HEG1, PRDX1 and ALCAM,PDIA4, TNC, MCAM, DC XR and MAMDC4, FGA, CLEC3B, MAMDC4, HEG1 and PDIA4, AREG, TNC, PKD1, MAMDC4 and TBCB, AREG, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, MCAM, DCXR, ALCAM and PRDX1, ADAM12, FAP, PRDX1, DCXR and IL17RA, SERPINA1, CEACAM5, CLEC3B, PRDX1 and ALCAM, CEACAM5, FGA, PEPD, HEG1 and AGR3, PDIA4, CEACAM5, PEPD, HEG1 and SL AMF8, PDIA4, TBCB, PEPD, FAP and ALCAM, PDIA4, PEPD, FAP, DCXR and LRG1, AREG, ADAM12, PKD1, DCXR and NCS1, CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2, SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD, ADAM12, MAMDC4, FAP, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD, AREG , PDIA4, PKD1, DCXR and ADAMTSL4, CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B, AREG, ADAM12, FGA, HEG1 and AGR3, AREG, FGA, HEG1, IL1RAP and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and PEPD, AREG, PKD1, DCXR, IL1RAP and MCAM, PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4, AREG, ADAM12, PDIA4, CD55 and NCS1, ADAM12, FGA, AGR3, IL 1RAP and TNC, SERPINA1, PEPD, IL1RAP, PLXDC2 and LRG1, AREG, PKD1, DCXR, IL1RAP and PEPD, TNC, AGR3, MAMDC4, IL1RAP and CEACAM5, AREG, TNC, MAMDC4, NCS1 and DCXR, AREG, PKD1, SLAMF8, DCXR and NCS1, AREG, TNC, MAMDC4, NCS1 and ALCAM, PDIA4, PRTN3, PEPD, FAP and ADAMTSL4, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB,CEACAM5, AGR3, SLAMF8, HEG1 and SERPINA1, PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B, ADAM12, FGA, FAP, PRDX1 and PEPD, TNC, CLEC3B, AGR3, IL1RAP and ADAMTSL4, CEACAM5, AGR3, SLAMF8, HEG1 and ALCAM, ADAM12, CEACAM5, FAP, PRDX1 and PDIA4, AREG, PDIA4, DCXR, ALCAM and NCS1, PDIA4, PRTN3, PEPD, FAP and TNC, SERPINA1, P EPD, IL1RAP, PLXDC2 and MAMDC4, AREG, PKD1, SLAMF8, DCXR and TBCB, FGA, AGR3, SLAMF8, HEG1 and PEPD, ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4, ADAM12, FGA, AGR3, IL1RAP and ALCAM, PDIA4, PRTN3, PEPD, FAP and SERPINA1, ADAM12, CLEC3B, AGR3, IL1RAP and NCS1, SERPINA1, PKD1, SLAMF8, DCXR and TBCB, ADAM12, MAMDC4, F AP, PRDX1 and ADAMTSL4, TNC, CLEC3B, AGR3, IL1RAP and PRDX1, AREG, PKD1, DCXR, IL1RAP and TNC, FGA, AGR3, SLAMF8, HEG1 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP and TBCB, SERPINA1, ADAM12, IL1RAP, PLXDC2 and DCXR, AREG, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and FGA, ADAM12, FGA, FAP, P RDX1 and NCS1, SERPINA1, AREG, IL1RAP, PLXDC2 and AGR3, PDIA4, CEACAM5, MEGF9, PEPD and ADAM12, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and NCS1, PDIA4, PEPD, DCXR, IL1RAP and ALCAM, SERPINA1, SLAMF8, PEPD, DCXR and MAMDC4, AREG, TNC, PKD1, MAMDC4 and FAP, PDIA4, PKD1, PEPD, DCXR and ADAMTSL4, PDIA4, MCAM, DCXR, ALCAM and CEACAM5,SERPINA1, CEACAM5, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ALCAM, PDIA4, FGA, PKD1, DCXR and PEPD, SERPINA1, PDIA4, PKD1, DCXR and MAMDC4, AREG, ADAM12, HEG1, IL1RAP and PDIA4, AREG, FGA, HEG1, IL1RAP and NCS1, ADAM12, TNC, AGR3, IL1RAP and SERPINA1, CEAC AM5, ADAMTSL4, SLAMF8, HEG1 and PDIA4, AREG, ADAM12, PKD1, DCXR and PRDX1, ADAM12, TNC, AGR3, IL1RAP and ITIH3, CEACAM5, FGA, PEPD, HEG1 and TNC, PDIA4, ADAMTSL4, PKD1, DCXR and NCS1, FGA, SLAMF8, PEPD, HEG1 and LRG1, PDIA4, PKD1, PEPD, DCXR and ALCAM, PDIA4, TNC, IGFB P2, MCAM and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CEACAM5, AREG, CEACAM5, HEG1, IL1RAP and PRDX1, ADAM12, CEACAM5, FAP, PRDX1 and ITIH3, PDIA4, TBCB, PKD 1, DCXR and ITIH3, AREG, TBCB, PKD1, DCXR and TNC, SERPINA1, SLAMF8, PEPD, DCXR and PDIA4, PDIA4, TNC, PEPD, FAP and CLEC3B, AREG, MAMDC4, IL1RAP, PLXDC2 and CLE C3B, PDIA4, TBCB, PKD1, DCXR and IL17RA, CEACAM5, FGA, PEPD, HEG1 and ADAM12, TNC, AGR3, MAMDC4, IL1RAP and PKD1, PDIA4, TNC, MCAM, DCXR and AGR3, PDIA4, PRTN3, PEPD, FAP and MCAM, PDIA4, TNC, MAMDC4, CD55 and DCXR, AREG, PDIA4, DCXR, ALCAM and PEPD, AREG, TNC, MAMDC4, NCS1 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and IL17RA, ADAM12, FGA, MAMDC4, HEG1 and PEPD, AREG, FGA, HEG1, IL1RAP and DCX R,ADAM12, FGA, AGR3, IL1RAP and PEPD, PDIA4, CEACAM5, PKD1, DCXR and NCS1, CE ACAM5, ADAMTSL4, HEG1, PRDX1 and IGFBP2, ADAM12, MAMDC4, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, PKD1, DCXR and MAMDC4, ADAM12, TNC, AGR3, IL1RAP and CLEC3B, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and CEACAM5, AREG, ADAM12, HEG1, IL1RAP and DCXR. C2 and NCS1, ADAM12, PDIA4, CD55, FAP and AGR3, PDIA4, TBCB, PEPD, FAP and PRDX1, ADAM12, LRG1, FAP, PRDX1 and PDIA4, PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8, PDIA4, PKD1, DCXR, IL1RAP and FAP, AREG, FGA, PEPD, HEG1 and ADAMTSL4, SERPINA1, TNC, DCXR, PLXDC2 and PDIA4, SERPINA1, MEGF 9. PRTN3, IL1RAP and AGR3, PDIA4, IGFBP2, PKD1, DCXR and IL17RA, SERPINA1, PDIA4, PKD1, DCXR and NCS1, PDIA4, TNC, MCAM, DCXR and NCS1, PDIA4, IGFBP2, PKD1, DCXR and ALCAM, PDIA4, PEPD, DCXR, IL1RAP and FAP, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1, PDIA4, FAP, DCXR, ALCAM and TBCB, AREG, CEACAM5, HEG1, IL1RAP and AGR 3, PDIA4, TNC, ITIH3, PKD1 and TBCB, SERPINA1, AREG, IL1RAP, PLXDC2 and TNC, ADAM12, DCXR, IL1RAP, ALCAM and MAMDC4, PDIA4, TBCB, PEPD, FAP and AGR3, PDIA4, FGA, IGFBP2, PKD1 and ITIH3, AREG, TNC, PKD1, MAMDC4 and ALCAM, ADAM12, CEACA M5, DCXR, IL1RAP and SERPINA1, AREG, MAMDC4, IL1RAP, PLXDC2 and MCAM,SERPINA 1, CEACAM5, CLEC3B, PRDX1 and AGR3, SERPINA1, SLAMF8, PEPD, DCXR and ALCAM, PDIA4, PEPD, HEG1, FAP and CEACAM5, AREG, ADAM12, TNC, NCS1 and PRDX1, CEACAM5, FGA, PEPD, HEG1 and DCXR, AREG, TBCB, PKD1, DCXR and NCS1, SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and TBCB, ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4.

4. CD55 and AGR3, PDIA4, PKD1, DCXR, IL1RAP and ADAMTSL4, ADAM12, PDIA4, CD55, FAP and TBCB, CEACAM5, AGR3, HEG1, PRDX1 and TBCB, FGA, SLAMF8, PEPD, HEG1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and TBCB, SERPINA1, PDIA4, MAMDC4, PLXD C2 and PEPD, PDIA4, FAP, DCXR, ALCAM and NCS1, PDIA4, IL17RA, DCXR, ALCAM and NCS 1, SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR, SERPINA1, CEACAM5, CLEC3B, PRDX1 and PDIA4, PDIA4, PEPD, DCXR, IL1RAP and PRDX1, SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD, ADAM12, PDIA4, DCXR, ALCAM and AGR3, CEACAM5, AGR3, SLAMF8, HEG1 and NCS1, ADAM12, MAMDC4, FAP, PRDX1 and ALCAM, AREG, TBCB, PKD1, DCXR and FAP, PDIA4, CEACAM5, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCA M, SERPINA1, AREG, PKD1, DCXR and ALCAM, AREG, ADAM12, PKD1, DCXR and ALCAM, AREG, PDIA4, DCXR, ALCAM and AGR3, ADAM12, PDIA4, CD55, FAP and PRDX1,SERPINA 1, SLAMF8, DCXR, PLXDC2 and TNC, ADAM12, PDIA4, PKD1, DCXR and AGR3, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and DCXR, SER PINA1, MEGF9, PRTN3, IL1RAP and TNC, CEACAM5, FGA, HEG1, PRDX1 and PEPD, PDIA4, PEPD, FAP, DCXR and TNC, PDIA4, FGA, IGFBP2, PKD1 and TBCB, SERPINA1, PDIA4, CEA CAM5, HEG1 and ADAM12, AREG, ADAM12, HEG1, IL1RAP and ITIH3, ADAM12, PDIA4, DCXR, ALCAM and IGFBP2, AREG, PDIA4, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL 1RAP and MAMDC4, SERPINA1, CEACAM5, IL1RAP, PLXDC2 and ADAM12, FGA, CLEC3B, MAMDC4, HEG1 and PRDX1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and LRG1, SERPINA1, PDI A4, MAMDC4, PLXDC2 and AGR3, SERPINA1, PDIA4, MAMDC4, PLXDC2 and TBCB, AREG, ADAM12, IL1RAP, PLXDC2 and DCXR, SERPINA1, AREG, FGA, HEG1 and PEPD, SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM, SERPINA1, PDIA4, PKD1, DCXR and AGR3, ADAM12, MAMDC4, FAP, PRDX1 and DCXR, PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4, PDIA4, CE ACAM5, MEGF9, PEPD and AGR3, PDIA4, ITIH3, PEPD, FAP and IL17RA, SERPINA1, AREG, PKD1, DCXR and PEPD, AREG, ADAM12, HEG1, IL1RAP and ALCAM, CEACAM5, FGA, PEP D, HEG1 and IGFBP2, PDIA4, CEACAM5, PEPD, HEG1 and TBCB, PDIA4, FGA, PKD1, DCXR and MAMDC4, PDIA4, CEACAM5, PKD1, DCXR and PEPD,ADAM12, DCXR, IL1RAP, ALCA M and CEACAM5, SERPINA1, AREG, IL1RAP, PLXDC2 and NCS1, PDIA4, DCXR, IL1RAP, AL CAM and CLEC3B, SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1, ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2, CEACAM5, TNC, FGA, HEG1 and MAMDC4, SERPINA1, TNC, DCXR, PL XDC2 and FAP, AREG, CEACAM5, FGA, HEG1 and MEGF9, FGA, AGR3, SLAMF8, HEG1 and FAP, SERPINA1, SLAMF8, DCXR, PLXDC2 and ALCAM, SERPINA1, PKD1, SLAMF8, DCXR and PDIA4, ADAM12, TBCB, FAP, PRDX1 and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and ALCA M, PDIA4, MCAM, DCXR, ALCAM and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and IL17RA, SERPINA1, AREG, IL1RAP, PLXDC2 and ALCAM, PDIA4, FGA, IGFBP2, PKD1 and ALCAM, PDIA4, TBCB, PEPD, FAP and MCAM, AREG, TBCB, PKD1, DCXR and PEPD, PDIA4, CEACA M5, PKD1, DCXR and TNC, SERPINA1, SLAMF8, PEPD, DCXR and ADAMTSL4, AREG, TNC, PKD1, MAMDC4 and DCXR, PDIA4, CEACAM5, DCXR, ALCAM and PEPD, SERPINA1, TBCB, SLAMF8, PLXDC2 and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and ALCAM, AREG, PKD1, DCXR, IL1RAP and TBCB, P DIA4, TNC, MAMDC4, CD55 and ADAM12, PDIA4, PKD1, PRTN3, PEPD and TBCB, ADAM12, FGA, MAMDC4, HEG1 and FAP, PDIA4, PKD1, PRTN3, PEPD and AGR3, PDIA4, CLEC3B, PKD1, DCXR and MAMDC4, SERPINA1, HEG1, IL1RAP, PLXDC2 and PEPD, ADAM12, PDIA4, PKD1, DCXR and NCS1,FGA, SLAMF8, PEPD, HEG1 and ALCAM, SE RPINA1, AREG, IL1RAP, PLXDC2 and TBCB, PDIA4, TBCB, PKD1, DCXR and LRG1, PDIA4, PEPD, DCXR, IL1RAP and NCS1, SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1, ADAM12, FG A, AGR3, IL1RAP and DCXR, AREG, ADAM12, PKD1, DCXR and IL17RA, ADAM12, CEACAM 5, DCXR, IL1RAP and FGA, TNC, CLEC3B, AGR3, IL1RAP and FAP, FGA, CLEC3B, MAMDC 4. HEG1 and AGR3, AREG, MAMDC4, IL1RAP, PLXDC2 and DCXR, CEACAM5, FGA, PEPD, HEG1 and TBCB, AREG, ADAM12, HEG1, IL1RAP and PEPD, ADAM12, PDIA4, CD55, FAP and ITIH3, AREG, PDIA4, CEACAM5, HEG1 and PEPD, PDIA4, ITIH3, PKD1, PEPD and DCXR, CE ACAM5, AGR3, HEG1, PRDX1 and SERPINA1, ADAM12, AGR3, MAMDC4, IL1RAP and DCXR, AREG, TBCB, PKD1, DCXR and ADAMTSL4, SERPINA1, PKD1, SLAMF8, DCXR and ALCAM, ADAM12, FGA, SLAMF8, NCS1 and IL17RA, PDIA4, PKD1, PEPD, DCXR and MCAM, CEACA M5, AGR3, HEG1, PRDX1 and CLEC3B, AREG, TBCB, PKD1, DCXR and AGR3, PDIA4, PRTN 3, PEPD, FAP and IL17RA, PDIA4, SLAMF8, MCAM, DCXR and PRDX1, FGA, AGR3, SLAMF 8. HEG1 and PDIA4, SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL4, PDIA4, FAP, DCXR, ALCAM and TNC, AREG, ADAM12, IL1RAP, PLXDC2 and AGR3, SERPINA1, PDIA4, PKD1, DCXR and CLEC3B, PDIA4, ADAMTSL4, PKD1, DCXR and SERPINA1, PDIA4, PKD1, DCXR, IL1RAP and IL17RA,ADAM12, TNC, FAP, PRDX1 and NCS1, SERPINA1, SLAMF8, DCXR, PLX DC2 and AGR3, FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5, ADAM12, CEACAM5, DCXR, IL1RAP and LRG1, ADAM12, FGA, SLAMF8, NCS1 and SERPINA1, ADAM12, PDIA4, CD55, FAP and IL17RA, SERPINA1, PEPD, IL1RAP, PLXDC2 and MCAM, PDIA4, PEPD, DCXR, IL1RA P and MAMDC4, PDIA4, PEPD, DCXR, IL1RAP and IGFBP2, ADAM12, SLAMF8, DCXR, IL1RAP and LRG1, AREG, PDIA4, CEACAM5, HEG1 and NCS1, PDIA4, TNC, MCAM, DCXR and PRDX1, PDIA4, CEACAM5, PEPD, HEG1 and PRDX1, SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2, PDIA4, ITIH3, PEPD, FAP and ALCAM, CEACAM5, AGR3, SLAMF8, HEG1 and LR G1, PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4, SERPINA1, PEPD, IL1RAP, PLXDC2 and DCXR, FGA, SLAMF8, PEPD, HEG1 and CLEC3B, ADAM12, DCXR, IL1RAP, ALCAM and ITIH3, AREG, ADAM12, PKD1, DCXR and MCAM, PDIA4, SLAMF8, MCAM, DCXR and FAP, ADAM12, TNC, AGR3, IL1RAP and TBCB, PDIA4, SLAMF8, MCAM, DCXR and SERPINA1, PDIA4, FGA, PKD1, DCXR and TBCB, PDIA4, FGA, PEPD, HEG1 and TNC, CEACAM5, ADAM TSL4, HEG1, PRDX1 and MAMDC4, ADAM12, MAMDC4, FAP, PRDX1 and CLEC3B, PDIA4, PKD1, PRTN3, PEPD and NCS1, PDIA4, TBCB, PKD1, DCXR and ADAM12, ADAM12, CEACAM 5, FGA, HEG1 and DCXR, AREG, ADAM12, FGA, HEG1 and PDIA4, CEACAM5, FGA, HEG1, PRDX1 and SERPINA1,CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4, PDIA4, TNC, MA MDC4, CD55 and NCS1, ADAM12, PEPD, FAP, PRDX1 and PDIA4, FGA, SLAMF8, PEPD, HE G1 and TNC, AREG, PDIA4, PKD1, DCXR and CEACAM5, SERPINA1, AREG, PKD1, DCXR and NCS1, PDIA4, TBCB, PKD1, DCXR and TNC, ADAM12, FGA, AGR3, IL1RAP and CLEC3B, PDIA4, IGFBP2, DCXR, ALCAM and TNC, AREG, ADAM12, HEG1, IL1RAP and PRDX1, PDIA4, C EACAM5, MEGF9, PEPD and NCS1, ADAM12, PDIA4, DCXR, ALCAM and IL17RA, SERPINA1, ADAM12, FAP, PRDX1 and TBCB, PDIA4, CEACAM5, PKD1, DCXR and FGA, AREG, ADAM12, IL1RAP, PLXDC2 and PDIA4, PDIA4, FGA, PKD1, DCXR and ASPN, CEACAM5, ADAMTSL 4, HEG1, PRDX1 and IL17RA, ADAM12, AGR3, MAMDC4, IL1RAP and PDIA4, AREG, TNC, MAMDC4, NCS1 and ITIH3, SERPINA1, AREG, FGA, HEG1 and PDIA4, PDIA4, CEACAM5, PEPD, HEG1 and NCS1, CEACAM5, SLAMF8, PEPD, HEG1 and IGFBP2, SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PDIA4, ADAM12, FGA, SLAMF8, NCS1 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and PEPD, PDIA4, PEPD, FAP, DCXR and NCS1, TNC, CLEC3B, AGR3, IL1RAP and CE ACAM5, SERPINA1, ADAM12, FAP, PRDX1 and PDIA4, PDIA4, PKD1, PRTN3, PEPD and PRD X1, SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8, ADAM12, FGA, AGR3, IL1RAP and PR DX1, PDIA4, ITIH3, PEPD, FAP and CEACAM5, CEACAM5, FGA, HEG1, PRDX1 and IL17RA,ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and IGFBP2, ADAM12, PDIA4, CD55, FAP and MAMDC4, AREG, ADAM12, PKD1, DCXR and CLEC3B, SER PINA1, PKD1, SLAMF8, DCXR and LRG1, CEACAM5, SLAMF8, PEPD, HEG1 and TNC, AREG, TNC, MAMDC4, NCS1 and MCAM, TNC, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, LRG1, FAP, PRDX1 and DCXR, PDIA4, ADAMTSL4, PKD1, DCXR and AGR3, AREG, TNC, PKD1, MAMDC4 and IGFBP2, ADAM12, TBCB, FAP, PRDX1 and DCXR, AREG, PDIA4, PKD1, DCXR and ALCAM, FGA, TBCB, MAMDC4, HEG1 and SERPINA1, ADAM12, TNC, AGR3, IL1RAP and PD IA4, SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM, PDIA4, ITIH3, PKD1, PEPD and IGFBP2, PDIA4, PEPD, DCXR, IL1RAP and ADAMTSL4, AREG, MAMDC4, IL1RAP, PLXDC2 and ALCA M, ADAM12, DCXR, IL1RAP, ALCAM and ADAMTSL4, PDIA4, CEACAM5, DCXR, ALCAM and NCS1, ADAM12, CEACAM5, DCXR, IL1RAP and PRDX1, CEACAM5, SLAMF8, HEG1, DC XR and AGR3, SERPINA1, PEPD, IL1RAP, PLXDC2 and ITIH3. XDC2 and ALCAM, ADAM12, FGA, FAP, PRDX1 and PDIA4, PDIA4, TNC, MAMDC4, CD55 and TBCB, AREG, FGA, PEPD, HEG1 and MAMDC4, FGA, AGR3, SLAMF8, HEG1 and LRG1, AD AM12, PDIA4, DCXR, ALCAM and MCAM, CEACAM5, SLAMF8, HEG1, DCXR and ALCAM, SERPINA1, CEACAM5, FGA, HEG1 and MCAM, ADAM12, TNC, FAP, PRDX1 and IGFBP2,ADA M12, SLAMF8, DCXR, IL1RAP and MAMDC4, AREG, PDIA4, DCXR, ALCAM and ADAM12, AREG, TBCB, PKD1, DCXR and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and PEPD, AREG, PDIA4, CEACAM5, HEG1 and DCXR, PDIA4, TBCB, PEPD, FAP and ADAMTSL4, SERPINA1, CLEC3B, IL1RAP, PLXDC2 and DCXR, PDIA4, PKD1, DCXR, IL1RAP and NCS1, AREG, MAMD C4, IL1RAP, PLXDC2 and PDIA4, SERPINA1, TNC, DCXR, PLXDC2 and AGR3, ADAM12, CLE C3B, AGR3, IL1RAP and CEACAM5, PDIA4, FGA, PKD1, DCXR and ADAMTSL4, PDIA4, ITIH 3. PKD1, PEPD and FAP, PDIA4, FGA, PKD1, DCXR and LRG1, PDIA4, CEACAM5, MEGF9, PEPD and ALCAM, ADAM12, FGA, MAMDC4, HEG1 and TNC, CEACAM5, FGA, HEG1, PRDX1 and PDIA4, ADAM12, CEACAM5, FAP, PRDX1 and ADAMTSL4, PDIA4, TNC, MCAM, DCXR and CLEC3B, PDIA4, TNC, MAMDC4, CD55 and FGA, AREG, FGA, HEG1, IL1RAP and FAP, CEACAM5, FGA, PEPD, HEG1 and ALCAM, AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3, PDI A4, PKD1, PRTN3, PEPD and MAMDC4, PDIA4, TNC, PEPD, FAP and ALCAM, AREG, FGA, PEPD, HEG1 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1 and ALCAM, SERPINA1, CEAC AM5, FGA, HEG1 and ASPN, SERPINA1, CEACAM5, CLEC3B, PRDX1 and MAMDC4, ADAM12, FGA, FAP, PRDX1 and IL17RA, PDIA4, FGA, PKD1, DCXR and NCS1, AREG, MAMDC4, IL1RAP, PLXDC2 and TNC, PDIA4, DCXR, IL1RAP, ALCAM and MAMDC4,SERPINA1, CEACAM5, FGA, HEG1 and AGR3, PDIA4, SLAMF8, MCAM, DCXR and AGR3, AREG, ADAM12, PKD1, DCXR and SERPINA1, PDIA4, IGFBP2, CD55, MCAM and DCXR, PDIA4, FGA, PKD1, DCXR and ALCAM, PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4, PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4, PDIA4, IGFBP2, PKD1, DCXR and LRG1, PDIA4, CEACAM5, PKD1, DCXR and LRG1, AREG, ADAM12, PKD1, DCXR and CEACAM5, ADAM12, DCXR, IL1RAP, ALCAM and PR DX1, ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4, PDIA4, PEPD, FAP, DCXR and AGR 3, TNC, AGR3, MAMDC4, IL1RAP and TBCB, ADAM12, PDIA4, DCXR, ALCAM and ADAMTS L4, CEACAM5, FGA, PEPD, HEG1 and NCS1, SERPINA1, PDIA4, MAMDC4, PLXDC2 and ALC AM, AREG, PDIA4, CEACAM5, HEG1 and PRDX1, ADAM12, TBCB, FAP, PRDX1 and CLEC3B, PDIA4, PEPD, HEG1, FAP and PRDX1, TNC, AGR3, MAMDC4, IL1RAP and PEPD, ADAM12, CEACAM5, FGA, HEG1 and PDIA4, PDIA4, IGFBP2, DCXR, ALCAM and TBCB, CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA, PDIA4, FGA, PEPD, HEG1 and TBCB, ADAM12, FGA, SLA MF8, NCS1 and ITIH3, AREG, TBCB, PKD1, DCXR and PDIA4, PDIA4, PKD1, PRTN3, PEPD and DCXR, PDIA4, PEPD, FAP, DCXR and CLEC3B, PDIA4, SLAMF8, MCAM, DCXR and MAMDC 4, AREG, PDIA4, DCXR, ALCAM and TBCB, SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3, SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4,ADAM12, PDIA4, DCXR, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1 and MAMDC4, AREG, PKD1, DCXR, IL1RAP and FAP, ADAM12, PDIA4, PKD1, DCXR and ITIH3, PDIA4, CLEC3B, PKD1, DCXR and AGR3, PDIA4, TNC, ITIH3, PKD1 and MAMDC4, SERPINA1, SLAMF8, PEPD, DCXR and IL17RA, FGA, TBCB, MAMDC 4, HEG1 and AGR3, PDIA4, TNC, PEPD, FAP and AGR3, SERPINA1, AREG, PKD1, DCXR and ADAMTSL4, or FGA, AGR3, SLAMF8, HEG1 and SERPINA1; Preferably, said A comprises a combination of 6 markers, and said combination of 6 markers is any six of said B; Preferably, the 6 markers are combined into b1) and b2): b1) the 5 markers combination; b2) any one of the above B; b2) is different from any one of the markers in the combination of 5 markers in b1); Preferably, the 6 markers combination is: SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7, PDIA4, CEACAM5, PKD1, DCXR, FGA and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and ITG A11, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PCDH7, SERPINA1, CEACAM5, FGA, HE G1, AGR3 and PEAR1, CEACAM5, FGA, HEG1, PRDX1, IL17RA and PCDH7, CEACAM5, FGA, PEPD, HEG1, NCS1 and CNTN4, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CKB, CEACAM 5, FGA, PEPD, HEG1, ALCAM and PEAR1, CEACAM5, FGA, PEPD, HEG1, TBCB and NAGPA, AREG, FGA, PEPD, HEG1, CEACAM5 and TINAGL1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and AGR3, CEACAM5, FGA, HEG1, PRDX1, IL17RA and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and DCXR, AREG, FGA, PEPD, HEG1, CEACAM5 and PDIA4, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PCDH7, TNC, AGR3, MAMDC4, IL1RAP, FGA and PRDX1, SE RPINA1, TNC, DCXR, PLXDC2, AGR3 and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and CD58, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PDIA4, AREG, FGA, PEPD, HEG1, CEACAM5 and AGR3, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and TINAGL1, CEACAM5, FGA, PEPD, HEG1, ALCAM and CKB, CEACAM5, FGA, PEPD, HEG1, ALCAM and CD58, PDIA4, CEACAM5, PKD1, DCXR, FGA and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and GDF 15, CEACAM5, FGA, HEG1, PRDX1, IL17RA and ITGAV, CEACAM5, FGA, PEPD, HEG1, NCS1 and TBCB,PDIA4, FGA, PKD1, DCXR, ALCAM and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and ENPP6, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and IGFBP2, CEACAM5, FGA, PEPD, HEG1, ALCAM and IGFBP2, AREG, FGA, PEPD, HEG1, CEACAM5 and ITGA11, ADAM12, FGA, SLAMF8, NCS1, DCXR and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and GDF15, CEACAM5, FGA, PEPD, HEG1, ALCAM with AGR3, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and COMP, CEACAM5, FGA, PEPD, HEG1, NCS1 and AGR3, CEACAM5, FGA, PEPD, HEG1, ALCAM and ACY1, CEACAM5, FGA, PEPD, HEG1, TNC and PDIA4, AREG, PDIA4, CEACAM5, HEG1, DCXR and PCDH7, FGA, AGR3, SLAMF8, HEG1, LRG1 and PCDH7, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PEAR1, CEACAM5, FGA, PEPD, HEG1, ALCAM and IT GA11, AREG, FGA, PEPD, HEG1, CEACAM5 and NAGPA, PDIA4, TNC, MAMDC4, CD55, FGA and CNTN4, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CANT1, CEACAM5, FGA, PEPD, HEG1, NCS1 and PCDH7, AREG, FGA, PEPD, HEG1, CEACAM5 and IGFBP2, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGA11, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CPM, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CPM, SERPINA1, CEACAM5, FGA, HEG1, MC AM and NCS1, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, ASPN and CANT1, CEACAM5, FGA, PEPD, HEG1, NCS1 and PEAR1, CEACAM5, FGA, PEPD, HEG1, NCS1 and ACY1,AREG, FGA, PEPD, HEG1, CEACAM5 and PRDX1, ADA M12, CEACAM5, FGA, HEG1, PDIA4 and CANT1, PDIA4, SLAMF8, MCAM, DCXR, AGR3 and PCDH7, CEACAM5, FGA, PEPD, HEG1, ALCAM and CA14, AREG, FGA, PEPD, HEG1, CEA CAM5 and NCS1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CNTN4, AREG, FGA, PEPD, HEG1, CEACAM5 and DCXR, CEACAM5, FGA, PEPD, HEG1, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ITGA11, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CNTN4, SERPINA1, CEACAM5, FGA, HEG1, MCAM and APOA4, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CD58, TNC, AGR3, MAMD C4, IL1RAP, TBCB and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and TINAGL1, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CPM, SERPINA1, CEACAM5, FGA, HEG1, ASPN and PDIA4, SERPINA1, CEACAM5, FGA, HEG1, MCAM and ACY1, SERPINA1, CEACAM5, FG A, HEG1, AGR3 and ACY1, CEACAM5, FGA, HEG1, PRDX1, IL17RA and ITGA11, CEACAM5, FGA, PEPD, HEG1, NCS1 and TINAGL1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and AGR3, PDIA4, TNC, MAMDC4, CD55, ADAMTSL4 and ITGA11, AREG, FGA, PEPD, HEG1, CEACA M5 and CNTN4, PDIA4, FGA, PKD1, DCXR, NCS1 and IGFBP2, CEACAM5, SLAMF8, PEPD, HEG1, TNC and PDIA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and PEAR1, CEACAM5, FGA, PEPD, HEG1, ALCAM and NCS1,CEACAM5, FGA, PEPD, HEG1, NCS1 and CD34, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and CNTN4, FGA, TBCB, MAMDC4, HEG1, AGR3 and PRDX1, ADAM12, FGA, FAP, PRDX1, MA MDC4 and CANT1, AREG, PDIA4, CEACAM5, HEG1, PRDX1 and AGR3, CEACAM5, FGA, HE G1, PRDX1, PDIA4 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and TINAGL1, SE RPINA1, CEACAM5, FGA, HEG1, MCAM and TBCB, AREG, FGA, PEPD, HEG1, CEACAM5 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CNTN4, TNC, AGR3, MAMDC4, IL1RAP, TBCB and PDIA4, CEACAM5, FGA, PEPD, HEG1, DCXR and ENPP6, SERPINA1, CEA CAM5, FGA, HEG1, MCAM and PEAR1, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CNTN4, CEACAM5, FGA, PEPD, HEG1, NCS1 and CPM, CEACAM5, FGA, PEPD, HEG1, NCS1 and CA 14. CEACAM5, FGA, HEG1, PRDX1, IL17RA and ACY1, TNC, AGR3, MAMDC4, IL1RAP, FGA and ENPP6, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4 and DCXR, ADAM12, FGA, MAM DC4, HEG1, TNC and TINAGL1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CD58, PDIA4, CEACAM5, PKD1, DCXR, FGA and CNTN4, PDIA4, TNC, MAMDC4, CD55, FGA and DCXR, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CANT1, AREG, FGA, PEPD, HEG1, CEACAM5 and CD34, PDIA4, CLEC3B, PKD1, DCXR, AGR3 and PCDH7, FGA, TBCB, MAMDC4, HEG1, AGR3 and CEACAM5,CEACAM5, FGA, HEG1, PRDX1, IL17RA and DCXR, AREG, ADAM12, PKD1, DCXR, CEACAM5 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and TBCB, CEACAM5, FGA, HEG1, PRDX1, PEPD and CFP, CEACAM5, FGA, PEPD, HEG1, ALCAM and TINAGL1, AREG, PDIA4, DCXR, ALCAM, ADAM12 and PEPD, AREG, FGA, PEPD, HEG1, CEACAM5 and TBCB, CEACAM5, FGA, PEPD, HEG1, ALCAM and GDF15, FGA, AGR3, SLAM F8, HEG1, SERPINA1 and DCXR, SERPINA1, CEACAM5, FGA, HEG1, ASPN and PCDH7, SERP INA1, TNC, DCXR, PLXDC2, AGR3 and IGFBP2, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PRDX1, AREG, FGA, PEPD, HEG1, CEACAM5 and COMP, CEACAM5, FGA, PEPD, HEG1, NCS1 and APOA4, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and TBCB, CEACAM5, FGA, HEG1, PRDX1, IL17RA and PPY, CEACAM5, FGA, PEPD, HEG1, ALCAM and PRDX1, TNC, AGR3, MAMDC4, IL1RAP, FGA and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and PCD H7, PDIA4, TNC, MAMDC4, CD55, TBCB and CPM, PDIA4, CEACAM5, PKD1, DCXR, FGA and PCDH7, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and TINAGL1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and TBCB, AREG, FGA, PEPD, HEG1, CEACAM5 and CA14, TNC, AGR3, MAMDC4, IL1RAP, FGA and GDF15, CEACAM5, FGA, PEPD, HEG1, TBCB and CFP, CEACAM 5, FGA, HEG1, PRDX1, PDIA4 and PCDH7, PDIA4, PKD1, DCXR, IL1RAP, NCS1 and CEACA M5,SERPINA1, CEACAM5, FGA, HEG1, ASPN and CNTN4, AREG, ADAM12, PKD1, DCXR, CEACAM5 and NAGPA, ADAM12, FGA, AGR3, IL 1RAP, PRDX1 and CPM, CEACAM5, FGA, HEG1, PRDX1, IL17RA and TINAGL1, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and PCDH7, CEACAM5, FGA, PEPD, HEG1, NCS1 and PRDX1, TNC, AGR3, MAMDC4, IL1RAP, FGA and CNTN4, AREG, FGA, PEPD, HEG1, CEACAM5 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CNTN4, ADAM12, CEAC AM5, FGA, HEG1, PDIA4 and DCXR, ADAM12, FGA, AGR3, IL1RAP, CEACAM5 and SPINT1, CEACAM5, FGA, PEPD, HEG1, NCS1 and IL17RA, CEACAM5, SLAMF8, HEG1, DCXR, AL CAM and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA and GDF15, SERPINA1, CEACAM5, FGA, HEG1, MCAM and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CANT1, ADAM12, TNC, FAP, PRDX1, IGFBP2 and CNTN4, AREG, PDIA4, CEACAM5, HEG1, DCXR and ITG AV, PDIA4, FGA, PKD1, DCXR, ALCAM and CPM, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and MFGE8, ADAM12, FGA, MAMDC4, HEG1, TNC and COMP, PDIA4, CEACAM5, PKD1, DCXR, FGA and AGR3, AREG, PDIA4, CEACAM5, HEG1, DCXR and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5 and CANT1, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ACY1, AREG, TBCB, PKD1, DCXR, ALCAM and ITGA11, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and PCDH7,CEACAM5, FGA, HEG1, PRDX1, IL17RA and CANT1, PDIA4, TNC, PEPD, FAP, ALCAM and AGR3, PDIA4, CEACAM5, MEGF9, PEPD, ALCAM and TINAGL1, PDIA4, FGA, PKD1, DCXR, LRG1 and ITGA11, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and CA14, TNC, AG R3, MAMDC4, IL1RAP, FGA and PCDH7, PDIA4, TNC, MAMDC4, CD55, FGA and CANT1, AREG, ADAM12, PKD1, DCXR, CEACAM5 and PEAR1, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and CD55, PDIA4, ITIH3, PKD1, PEPD, FAP and CEACAM5, SERPINA1, CEACA M5, FGA, HEG1, ASPN and COMP, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and MAMDC4, TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and PDIA4, CEACAM5, FGA, PEPD, HEG1, TNC and TBCB, TNC, AGR3, MAMDC4, IL1RAP, FGA and TBCB, CEACAM5, FGA, PEPD, HEG1, NCS1 and ITGAV, CEACAM5, SLAMF8, PEPD, HEG1, TNC and ITGA11, TNC, AGR3, MAMDC4, IL1RAP, FGA and TINAGL1, CEACAM5, FGA, PEPD, HEG1, ALCAM and PCDH7, PDIA4, FG A, PKD1, DCXR, ADAMTSL4 and PCDH7, AREG, FGA, HEG1, IL1RAP, FAP and ITGA11, PD IA4, IGFBP2, DCXR, ALCAM, TNC and TBCB, SERPINA1, PDIA4, CEACAM5, HEG1, SLAM F8 and CFP, ADAM12, PDIA4, DCXR, ALCAM, TBCB and PCDH7, CEACAM5, FGA, PEPD, HEG1, TBCB and MZB1, CEACAM5, FGA, PEPD, HEG1, ALCAM and PPY, AREG, FGA, PEPD, HEG1, CEACAM5 and CKB, FGA, AGR3, SLAMF8, HEG1, LRG1 and GDF15, CEACAM5, FGA, HEG1, PRDX1, IL17RA and COMP,CEACAM5, FGA, HEG1, PRDX1, PDIA4 and TINAGL1, ADAM12, FGA, AGR3, IL1RAP, PRDX1 and CFP, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TBCB, AREG, PDIA4, CEACAM5, HEG1, DCXR and CD58, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and GDF15, PDIA4, TNC, PEPD, FAP, AGR3 and CANT1, CEACAM5, SLAMF8, PEP D, HEG1, TNC and CD34, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TINAGL1, TNC, AGR3, MAMDC4, IL1RAP, PEPD and TINAGL1, AREG, FGA, PEPD, HEG1, CEACAM5 and ACY1, FGA, AGR3, SLAMF8, HEG1, LRG1 and CPM, CEACAM5, FGA, HEG1, PRDX1, PEPD and MZB1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CA14, CEACAM5, FGA, PEPD, HEG1, ALCAM and PDIA4, AREG, FGA, PEPD, HEG1, CEACAM5 and CDH23, SERPINA1, SL AMF8, PEPD, DCXR, IL17RA and PCDH7, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CD34, PDIA4, CEACAM5, PKD1, DCXR, FGA and ACY1, CEACAM5, FGA, PEPD, HEG1, ALCAM and CNTN4, ADAM12, FGA, FAP, PRDX1, MAMDC4 and CNTN4, ADAM12, FGA, FAP, PRD X1, MAMDC4 and ITGA11, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and IL17RA, FGA, AG R3, SLAMF8, HEG1, CEACAM5 and PKD1, FGA, AGR3, SLAMF8, HEG1, LRG1 and CKB, PDIA4, CEACAM5, PKD1, DCXR, FGA and ITGA11, AREG, ADAM12, PKD1, DCXR, CEACA M5 and TNC, CEACAM5, SLAMF8, PEPD, HEG1, TNC and DCXR, AREG, ADAM12, PKD1, DCXR, CEACAM5 and PEPD, AREG, FGA, PEPD, HEG1, CEACAM5 and CFP,SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CPM, CEACAM5, FGA, PEPD, HEG1, NCS1 and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TINAGL1, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM and DCXR, CEACAM5, FGA, PEPD, HEG1, NCS1 and TNC, SERPINA1, CEACAM5, FGA, HEG1, ASPN and PEAR1, ADAM12, PDIA4, DCXR, ALCAM, TBCB and AGR3, AREG, ADAM12, PKD1, DCXR, SERPINA1 and TN C, SERPINA1, AREG, PKD1, DCXR, ADAMTSL4 and PCDH7, ADAM12, FGA, FAP, PRDX1, MAMDC4 and CEACAM5, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and NCS1, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5 and CPM, PDIA4, TNC, MAMDC4, CD55, ADAMTSL4 and CPM, AREG, FGA, PEPD, HEG1, CEACAM5 and CPM , SERPINA1, CEACAM5, FGA, HEG1, AGR3 and NCS1, CEACAM5, FGA, PEPD, HEG1, ALCAM and ITGAV, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and MAMDC4, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CANT1, CEACAM5, FGA, PEPD, HEG1, DCXR and CLEC3B, PDIA4, PKD1, DCXR, IL1RAP, PEPD and ENPP6, SE RPINA1, AREG, FGA, HEG1, PDIA4 and DPP4, SERPINA1, CLEC3B, IL1RAP, PLXDC2, DC XR and TNC, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CD58, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and TBCB, CEACAM5, SLAMF8, PEPD, HEG1, TNC and AGR3, FGA, TBCB, MAMDC4, HEG1, AGR3 and PEAR1, ADAM12, FGA, FAP, PRDX1, PDIA4 and TBCB,CEACAM 5, SLAMF8, HEG1, DCXR, AGR3 and GDF15, SERPINA1, CEACAM5, FGA, HEG1, ASPN and TNC, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CD58, PDIA4, PEPD, FAP, DCXR, CLEC3B and PEAR1, CEACAM5, FGA, PEPD, HEG1, TNC and NAGPA, FGA, CLEC3B, MAMDC 4, HEG1, CEACAM5 and PCDH7, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and CANT1, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ACY1, CEACAM5, FGA, HEG1, PRDX1, IL17RA and AGR3, PDIA4, TNC, MAMDC4, CD55, FGA and TBCB, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CNTN4, CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and CANT1, CEACAM 5. ADAMTSL4, HEG1, PRDX1, IL17RA and CNTN4, AREG, FGA, PEPD, HEG1, MAMDC4 and NCS1, FGA, AGR3, SLAMF8, HEG1, LRG1 and ACY1, FGA, AGR3, SLAMF8, HEG1, CEA CAM5 and PDIA4, PDIA4, FGA, PKD1, DCXR, NCS1 and CPM, AREG, ADAM12, PKD1, DCX R, CEACAM5 and CD34, AREG, TNC, PKD1, MAMDC4, IGFBP2 and ACY1, PDIA4, FGA, PK D1, DCXR, ALCAM and TBCB, FGA, TBCB, MAMDC4, HEG1, AGR3 and ITGA11, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and KHK, FGA, TBCB, MAMDC4, HEG1, AGR3 and CNTN4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4 and CEACAM5, PDIA4, CEACAM5, MEGF9, PEPD, NCS1 and AGR3, AREG, TNC, MAMDC4, NCS1, MCAM and TBCB, ADAM12, DCXR, IL1RAP, ALCAM, PRDX1 and PEPD, AREG, ADAM12, PKD1, DCXR, CEACAM5 and CPM,AREG, FGA, PEPD, HEG1, CEACAM5 and CANT1, AREG, PKD1, DCXR, IL1RAP, FAP and PE PD, AREG, FGA, PEPD, HEG1, MAMDC4 and CEACAM5, SERPINA1, CEACAM5, FGA, HE G1, AGR3 and TNC, SERPINA1, CEACAM5, FGA, HEG1, MCAM and KHK, PDIA4, CEACAM5, DCXR, ALCAM, NCS1 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and TINAGL1, CEACAM5, AGR3, HEG1, PRDX1, FGA and PCDH7, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CKB, TNC, AGR3, MAMDC4, IL1RAP , TBCB and COMP, SERPINA1, CEACAM5, FGA, HEG1, ASPN and CPM, CEACAM5, FGA, HEG1, PRDX1, IL17RA and KHK, PDIA4, PKD1, DCXR, IL1RAP, PEPD and ITGA11, CEACAM5, FGA, PEPD, HEG1, ALCAM and APOA4, PDIA4, TNC, MAMDC4, CD55, TBCB and AGR3, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CK B, PDIA4, FGA, PKD1, DCXR, ASPN and PCDH7, TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and CNTN4, AREG, PKD1, DCXR, IL1RAP, FAP and ITGA11, CEACAM5, FGA, PEPD, HEG1, DCXR and SSC4D, CEACAM5, FGA, PEPD, HEG1, NCS1 and CANT1, AREG, TNC, PKD1, MAMDC4, IGFBP2 and CANT1, ADAM12, TNC, A GR3, IL1RAP, PDIA4 and CNTN4, PDIA4, PEPD, FAP, DCXR, NCS1 and PCDH7, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and AGR3, TNC, AGR3, MAMDC4, IL1RAP, PDIA4 and CA14, ADAM12, CEACAM5, DCXR, IL1RAP, FGA and PCDH7, CEACAM5, SLAMF8, PEPD, HEG1, TNC and ITGAV, CEACAM5, FGA, PEPD, HEG 1, AGR3 and TBCB,AREG, FGA, PEPD, HEG1, CEACAM5 and ENPP6, AREG, FGA, PEPD, HEG1, MAMDC4 and CNTN4, PDIA4, CEACAM5, MEGF9, PEPD, ALCAM and PCDH7, PDIA4, IGFBP2, DCXR, ALCAM, TNC and PCDH7, PDIA4, FGA, PKD1, DCXR, NCS1 and GDF15, FGA, AGR3, SLAMF8, HEG1, LRG1 and T INAGL1, PDIA4, TNC, ITIH3, PKD1, MAMDC4 and CANT1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and CANT1, ADAM12, FGA, SLAMF8, NCS1, DCXR and CNTN4, CEACAM5, FGA, HEG1, PRDX1, IL17RA and IGFBP2, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and ITGA11, ADA M12, FGA, AGR3, IL1RAP, PRDX1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CPM, PDIA4, FGA, PKD1, DCXR, ASPN and TBCB, SERPINA1, ADAM12, FAP, PRDX1, TBCB and AGR3, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CPM, CEACAM5, FGA, PEPD, HEG1, ALCAM with CPM, AREG, FGA, HEG1, IL1RAP, FAP and CKB, CEACAM5, TNC, FGA, HEG1, DCXR and IL1R2, CEACAM5, FGA, HEG1, PRDX1, IL17RA and CA14, AREG, FGA, PEPD, HEG1, CEACAM5 and ITGAV, AREG, TBCB, PKD1, DCXR, NCS1 and PEPD, PDIA4, FGA, PKD1, DCXR, ALCAM and IGFBP 2, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and IGFBP2, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and CANT1, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CNTN4, AREG, ADAM12, PKD1, DCXR, CEACAM5 and AGR3, ADAM12, CEACAM5, DCXR, IL1RAP, FGA and SSC 4D, PDIA4, FGA, PKD1, DCXR, ASPN and ITGA11,CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and PCDH7, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CD55, PDIA4, FGA, PKD1, DCXR, NCS1 and PEAR1, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and DDC, PDIA4, TNC, PEPD, FAP, AGR3 and CEACAM5, AREG, FGA, PEPD, HEG1, CEACAM5 and CD58, CEACAM5, FGA, PEPD, HEG1, ALCAM and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and GDF15, FGA, TBCB, MAMDC4, HEG1, AGR3 and TINAGL1, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and CANT1, CEACAM5, TNC, FGA, HEG1, DCXR and TBCB, ADAM12, TNC, FAP, PR DX1, IGFBP2 and CPM, CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ITGAV, CEACAM5, FGA, HEG1, PRDX1, IL17RA and TBCB, AREG, FGA, HEG1, IL1RAP, FAP and MAMDC4, PDIA4, SLAMF8, MCAM, DCXR, AGR3 and IGFBP2, ADAM12, CLEC3B, AGR3, IL1RAP, CEACAM5 and CA14, SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGAV, PDIA4, CEACAM5, MEGF9, PEPD, NCS1 and TBCB, PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and CNT N4, AREG, TBCB, PKD1, DCXR, ALCAM and HPGDS, PDIA4, PKD1, DCXR, IL1RAP, NCS1 and SSC4D, ADAM12, FGA, MAMDC4, HEG1, TNC and CD34, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CKB, PDIA4, FGA, PKD1, DCXR, ALCAM and PCDH7, PDIA4, CEACAM5, DCXR, ALCAM, NCS1 and TNC, PDIA4, CEACAM5, PKD1, DCXR, FGA and MCAM, PDIA4, TNC, MAMDC4, CD55, FGA and AGR3, PDIA4, ITIH3, PKD1, PEPD, FAP and CANT1,PDIA4, FGA, PKD1, DCXR, NCS1 and CNTN4, ADAM12, PDIA4, DCXR, ALCAM, ADAMTSL4 and CNTN4, AREG, MAMDC 4, IL1RAP, PLXDC2, TNC and ITGA11, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PDIA4, ADAM12, PDIA4, CD55, FAP, MAMDC4 and CEACAM5, AREG, PDIA4, PKD1, DCXR, ALC AM and DDC, ADAM12, PDIA4, DCXR, ALCAM, TBCB and CEACAM5, CEACAM5, FGA, HE G1, PRDX1, PDIA4 and TBCB, PDIA4, FGA, PKD1, DCXR, NCS1 and TBCB, M5, DCXR, ALCAM, NCS1 and PRDX1, AREG, ADAM12, IL1RAP, PLXDC2, PDIA4 and CD58, AREG, PDIA4, PKD1, DCXR, ALCAM and DPP4, PDIA4, CEACAM5, PKD1, DCXR, FGA and TBCB, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and AGR3, CEACAM5, AGR3, HEG1, PRD X1, ALCAM and DCXR, CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and COMP, PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and CKB, AREG, TNC, MAMDC4, NCS1, ITIH3 and CD58, SERPIN A1, CEACAM5, FGA, HEG1, AGR3 and CKB, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CNTN4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and ACY1, ADAM12, FGA, MAMDC4, HE G1, TNC and ITGAV, AREG, PDIA4, PKD1, DCXR, ALCAM and NCS1, CEACAM5, ADAMTS L4, HEG1, PRDX1, IL17RA and AGR3, PDIA4, CEACAM5, PKD1, DCXR, FGA and CFP, CEA CAM5, FGA, HEG1, PRDX1, PDIA4 and NCS1, FGA, TBCB, MAMDC4, HEG1, SERPINA1 and CNTN4, PDIA4, CEACAM5, PKD1, DCXR, FGA and CKB,ADAM12, FGA, SLAMF8, NCS1, DCXR and PCDH7, CEACAM5, FGA, PEPD, HEG1, NCS1 and ITIH3, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CPM, PDIA4, IGFBP2, PKD1, DCXR, LRG1 and AGR3, PDIA4, CEACA M5, PKD1, DCXR, FGA and SERPINA1, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and AGR3, FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PDIA4, CEACAM5, SLAMF8, PEPD, H EG1, IL17RA and ITGA11, ADAM12, DCXR, IL1RAP, ALCAM, PRDX1 and DPP4, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and COMP, SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and CE ACAM5, PDIA4, CEACAM5, MEGF9, PEPD, DCXR and FAP, CEACAM5, SLAMF8, PEPD, HEG1, TNC and CNTN4, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and IL17RA, ADAM12, CEA CAM5, FAP, PRDX1, ADAMTSL4 and CNTN4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC 4 and PCDH7, SERPINA1, SLAMF8, PEPD, DCXR, IL17RA and ENPP6, CEACAM5, FGA, HEG 1, PRDX1, IL17RA and PDIA4, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TBCB, ADAM12, FGA, FAP, PRDX1, MAMDC4 and PDIA4, ADAM12, CEACAM5, DCXR, IL1RAP, PRDX1 and APOA4, CEACAM5, SLAMF8, PEPD, HEG1, TNC and TBCB, SERPINA1, CEACAM5, FGA, HEG1, MCAM and PPY, CEACAM5, FGA, PEPD, HEG1, ALCAM and CD34, CEACAM5, SLA MF8, PEPD, HEG1, IL17RA and TNC, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and TNC, SERPINA1, TNC, DCXR, PLXDC2, AGR3 and ACY1,AREG, TNC, PKD1, MAMDC4, IGFBP2 and CD58, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and ACY1, CEACAM5, FGA, HEG1, PRDX1, PEPD and TBCB, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and ITGAV, ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CD34, PDIA4, FGA, PKD1, DCXR, LRG1 and IGFBP2, TN C, AGR3, MAMDC4, IL1RAP, IGFBP2 and CPM, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5 and ACY1, AREG, FGA, PEPD, HEG1, MAMDC4 and CANT1, PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CA14, AREG, TBCB, PKD1, DCXR, ALCAM and CNTN4, PDIA4, FGA, PEPD, HEG1, TBCB and NCS1, PDIA4, ADAMTSL4, PKD1, DCXR, AGR3 and CANT1, PDIA4, CEAC AM5, PEPD, HEG1, NCS1 and COMP, PDIA4, FGA, PEPD, HEG1, TBCB and ITGA11, SERPI NA1, PKD1, SLAMF8, DCXR, LRG1 and PEAR1, AREG, PKD1, SLAMF8, DCXR, TBCB and LILRA4, SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and TINAGL1, SERPINA1, CEACAM 5, FGA, HEG1, MCAM and CANT1, ADAM12, FGA, MAMDC4, HEG1, TNC and CEACAM5, AREG, MAMDC4, IL1RAP, PLXDC2, TNC and PDIA4, ADAM12, CEACAM5, FGA, HEG1, PKD1 and PDIA4, SERPINA1, AREG, FGA, HEG1, PDIA4 and ITGA11, FGA, AGR3, SLAMF8, HEG1, LRG1 and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3 and APOA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and C1QTNF1, TNC, AGR3, MAMDC4, IL1RAP, TBCB and CNT N4, ADAM12, PDIA4, DCXR, ALCAM, TBCB and CPM,PDIA4, FGA, PKD1, DCXR, LRG1 and PEAR1, AREG, FGA, PEPD, HEG1, CEACAM5 and GDF15, AREG, ADAM12, IL1RAP, PL XDC2, PDIA4 and NCS1, FGA, TBCB, MAMDC4, HEG1, SERPINA1 and COMP, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and CDH23, ADAM12, FGA, AGR3, IL1RAP, PRDX1 and CKB, ADAM12, AGR3, MAMDC4, IL1RAP, PDIA4 and TINAGL1, ADAM12, FGA, MAMDC4, HEG1, TNC and AGR3, PDIA4, CEACAM M5, MEGF9, PEPD, ALCAM and CKB, PDIA4, IGFBP2, DCXR, ALCAM, TNC and PRDX1, CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and CANT1, TNC, AGR3, MAMDC4, IL1RAP, PEPD and ITGA11, SERPINA1, CEACAM5, FGA, HEG1, MCAM and MAMDC4, CEACAM5, FG A, HEG1, PRDX1, IL17RA and NCS1, CEACAM5, TNC, FGA, HEG1, MAMDC4 and IGFBP2, AREG, PDIA4, CEACAM5, HEG1, PRDX1 and C1QTNF1, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CFP, CEACAM5, FGA, PEPD, HEG1, TNC and PCDH7, FGA, AGR3, SLAMF8, HEG1, LRG1 and CNTN4, CEACAM5, AGR3, HEG1, PRDX1, ALCAM and PDIA4, or SERPINA1, MEGF9, PRTN3, IL1RAP, MCAM and RPGR; Preferably, said A comprises a combination of 7 markers, and said combination of 7 markers is any seven of said B; Preferably, the 7 markers are combined into c1) and c2): c1) the 6 markers combination; c2) any one of the above B; Said c2) is different from any one of the markers in the combination of 6 markers in c1); Preferably, the 7 markers combination is: ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HE G1, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and HEG1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and LILRA4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and PEAR1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and PEAR1 ,AREG,ADAM12,PKD1,DCXR,CEACAM5,CANT1 AND LILRA4,ADAM12,CEACAM5,DCXR,IL1RAP,FGA,PCDH7 AND PDIA4,ADAM12,CEACAM5,FGA,HEG1,PDIA4,KHK AND ADAMTSL4,ADAM12,SLAMF8,DCXR,IL1RAP,MAMDC4,CEACAM5 AND NCS1,ADAM12,CEACAM5,FGA,HEG1,PDIA4,KHK AND LILRA4,AREG,ADAM12,PKD1,DCXR,CEACAM5,PEAR1 AND COMP,ADAM12,CEACAM5,FGA,HEG1,PDIA4,AGR3 AND IL17RA,ADAM12,CEACAM5,FG A, HEG1, PDIA4, KHK and CLEC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and FAP, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and MCAM, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, DCX R and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and AGR3,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT 1 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and ADAMTSL4, ADAM12, CEAC AM5, FGA, HEG1, PDIA4, MAMDC4 and FAP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and PDIA4, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and NCS1, AREG, ADAM12, PK D1, DCXR, CEACAM5, CANT1 and NCS1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH 7 and COMP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and NCS1, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and NCS1, AREG, ADAM12, PK D1, DCXR, CEACAM5, PEAR1 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and LRCH4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and HEG1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and HEG1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and ADAM TSL4,ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MAMDC4,AREG, ADAM12, PK D1, DCXR, CEACAM5, TNC and NCS1,ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and IL17RA,AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and NCS1,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and SSC4D, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and MZ B1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, COMP and LILRA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and NCS1, TNC, AGR3, MAMDC4, IL1RAP, FGA, PRDX1 and COMP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and NCS1, ADAM 12, CEACAM5, DCXR, IL1RAP, PRDX1, APOA4 and COMP, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and C1QTNF1, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and MCA M,AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and LILRA4,SERPINA1, CEACAM5, FGA, HEG1, AGR3, CANT1 and IL17RA,AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and PDIA4,AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and PRDX1,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and CLEC3B,ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and ADAM TSL4,CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7 and RAB37, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and NCS 1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and AGR3, ADAM12, FGA, FAP, PRDX 1, MAMDC4, CEACAM5 and AGR3, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and FA P, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and IL17RA. R, CEACAM5, TNC and AGR3, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and MCAM, PDI A4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5 and RAB37, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and HEG1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and ITGA11, AREG, FGA, PEPD, HEG1, CEACAM5, DCXR and PEAR1, ADAM12, CEACAM5 M5, FGA, HEG1, PDIA4, CANT1 and NCS1,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT 1 and ADAMTSL4,CEACAM5, FGA, PEPD, HEG1, ALCAM, CA14 and DPP4,SERPINA1, CEACA M5, FGA, HEG1, MCAM, PEAR1 and PCDH7,AREG, ADAM12, PKD1, DCXR, CEACAM5, PE AR1 and IL17RA,ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and CDH23,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and ADAMTSL4,ADAM12, FGA, AGR3, IL1RAP, CEACA M5, SPINT1 and PRDX1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and PRDX1,CEACAM5, SLAMF8, HEG1, DCXR, AGR3, IL17RA and CDH23, ADAM12, SLAMF8, DCXR, IL1RAP, MA MDC4, CEACAM5 and PEAR1, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and AGR3, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and HEG1, TNC, AGR3, MAMDC4, IL1RAP, PEPD, TINAGL1 and HEG1, ADAM 12, FGA, AGR3, IL1RAP, PRDX1, CPM and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA 4. DCXR and LILRA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and NCS1, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and FAP, FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5 and IL17RA, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and FAP, ADA M12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and PCDH7, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and HEG1, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and RTN4R, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and LRCH4, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and IL17RA, ADAM12, CE ACAM5, FGA, HEG1, PDIA4, ITGA11 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and CPM, AREG, FGA, PEPD, HEG1, CEACAM5, NCS1 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA 11 and IL17RA,CEACAM5, FGA, PEPD, HEG1, NCS1, PEAR1 and LILRA4, AREG, ADAM12, PK D1, DCXR, CEACAM5, PEPD and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and IL17RA, CEACAM5, FGA, PEPD, HEG1, ALCAM, TINAGL1 and PEAR1, AREG, ADAM12, PKD 1. DCXR, CEACAM5, ITGA11 and ADAMTSL4, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and MCAM, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, PCDH7 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and PRDX1, SERPINA1, CEA CAM5, FGA, HEG1, AGR3, PEAR1 and MCAM, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and MCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and MCAM. ACAM5, FGA, HEG1, PDIA4, MAMDC4 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and C1QTNF1, AREG, ADA M12, PKD1, DCXR, CEACAM5, TNC and MAMDC4, ADAM12, CEACAM5, FGA, HEG1, PDIA 4, AGR3 and LRCH4, ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and PDIA4, CEA CAM5, AGR3, HEG1, PRDX1, ALCAM, NCS1 and IL17RA, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and ADAMTSL4, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and PDIA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PCDH7,CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB and IL17RA,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and LILRA 4, FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5 and MCAM, CEACAM5, FGA, HEG1, PRD X1, IL17RA, CNTN4 and IL1RAP, TNC, AGR3, MAMDC4, IL1RAP, PDIA4, CA14 and HEG1, ADA M12, CEACAM5, FGA, HEG1, PDIA4, KHK and NCS1, SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and NCS1, CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1 and FAP, CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and ADAMTSL4, ADAM12, SLAM F8, DCXR, IL1RAP, MAMDC4, CEACAM5 and ADAMTSL4, CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR3 and IL17RA, PDIA4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5 and COMP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and RAB37, ADAM12, FGA, FAP, PRDX1, MAMDC 4. CEACAM5 and LRCH4, CEACAM5, FGA, PEPD, HEG1, ALCAM, TBCB and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PEAR1, TNC, AGR3, MAMDC4, IL1RAP, FGA, TBCB and MCAM, CEACAM5, FGA, PEPD, HEG1, ALCAM, CKB and IL17RA, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and CLEC3B, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SP INT1 and COMP, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and MCAM,CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and CLEC 3B,ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and PLXDC2,ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and ESM1,AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1 and RAB37,CEACAM5, SLAMF8, PEPD, HEG1, TNC, CPM and PEAR1,PDIA4, CEACAM5, MEGF9, PEPD, NCS1, AGR3 and RAB37,AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and RAB37,CEACAM 5, FGA, PEPD, HEG1, NCS1, ACY1 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR3 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and MZB1, CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15 and PEAR1, CEACAM5, SLAMF8, HEG1, DCXR, AGR3, PEAR1 and RAB37, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and GNAS, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMD C4 and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and RAB37, AREG, ADAM12, PK D1, DCXR, CEACAM5, CANT1 and PEAR1, SERPINA1, CEACAM5, FGA, HEG1, ASPN, CANT 1 and AGR3, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and MZB1, ADAM12, FGA, MA MDC4, HEG1, TNC, COMP and PRDX1, AREG, PDIA4, CEACAM5, HEG1, DCXR, PCDH7 and CDH23,ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and PRDX1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and HE G1, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and MAMDC4, ADAM12, CEACAM5, DCX R, IL1RAP, FGA, PCDH7 and RAB37, PDIA4, CEACAM5, PKD1, DCXR, FGA, PEAR1 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, ITGA11 and IL1RAP, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and CKB, CEACAM5, FGA, PEPD, HEG1, NCS1, GDF15 and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and FAP, PDIA4, CEACAM5, PKD1, DCXR, FGA, ITGA11 and CDH23, ADAM12, CEACAM5 ACAM5, FGA, HEG1, PDIA4, ITGA11 and LRCH4, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and FAP, AREG, FGA, PEPD, HEG1, CEACAM5, TBCB and ADAMTSL4, AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1 and IL17RA, AD AM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and MCAM, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and MCAM, AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and NCS1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and NCS 1, SERPINA1, CEACAM5, FGA, HEG1, AGR3, ACY1 and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and ADAMT SL4, TNC, AGR3, MAMDC4, IL1RAP, FGA, PCDH7 and NCS1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and IL17RA,ADAM12, CEACAM5, FGA, HEG 1, PDIA4, CANT1 and FAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11 and NCS1, AREG, FGA, PEPD, HEG1, CEACAM5, TBCB and LILRA4, AREG, ADAM12, PKD1, DCXR, CEACAM 5, ITGA11 and MCAM, ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, IL17RA and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, COMP and MZB1, CEACAM5, FGA, HEG1, PRDX1, PDIA4, PEAR1 and RAB37, AREG, AD AM12, PKD1, DCXR, CEACAM5, PEPD and LILRA4, ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1 and IL1RAP, CEACAM5, FGA, PEPD, HEG1, ALCAM, PDIA4 and AGR3, CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and MCAM, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, ITGA11 and MCAM, ADAM12, CEACA M5, FGA, HEG1, PDIA4, AGR3 and NCS1, AREG, FGA, PEPD, HEG1, CEACAM5, CKB and IL1RAP, AREG, FGA, PEPD, HEG1, CEACAM5, CANT1 and PCDH7, SERPINA1, CEACAM5, FGA, HEG1, AGR3, TNC and PEAR1, AREG, FGA, PEPD, HEG1, CEACAM5, NCS1 and PCDH7, CEACA M5, FGA, PEPD, HEG1, ALCAM, ACY1 and MCAM, CEACAM5, FGA, PEPD, HEG1, TNC, TBCB and NCS1, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and CLEC3B, SERPINA1, CE ACAM5, FGA, HEG1, AGR3, CNTN4 and IL1RAP, SERPINA1, CEACAM5, FGA, HEG1, AGR3, PDIA4 and IL17RA,TNC, AGR3, MAMDC4, IL1RAP, FGA, ENPP6 and COMP, CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7 and PEAR1, CEACAM5, FGA, PEPD, HEG1, TNC, TBCB and C1QTNF1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and PEAR1, ADAM12, CEACAM5, FG A, HEG1, PDIA4, TBCB and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and CDH23, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and ADAMTSL4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and RAB37, ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and PEA R1, TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and COMP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and C1QTNF1, CEACAM5, FGA, HEG1, PRDX1, PDIA4, ACY1 and AGR3, CE ACAM5, FGA, PEPD, HEG1, NCS1, CD58 and CLEC3B, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and IL1RAP, ADAM12, CEAC AM5, FGA, HEG1, PDIA4, CNTN4 and LILRA4, FGA, TBCB, MAMDC4, HEG1, AGR3, CEAC AM5 and COMP,SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and PCDH7,ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and COMP,SERPINA1, CEACAM5, FGA, HEG1, MCAM, NCS1 and AGR3,PDIA4, CEACAM5, PKD1, DCXR, FGA, AGR3 and IL17RA,AREG, ADA M12, PKD1, DCXR, CEACAM5, PEAR1 and ITGA11,ADAM12, CEACAM5, FGA, HEG1, PDIA 4, CNTN4 and MAMDC4, FGA, AGR3, SLAMF8, HEG1, CEACAM5, PDIA4 and IL1RAP,AREG, FGA, PEPD, HEG1, CEACAM5, PDIA4 and IL17RA, AREG, PDIA4, CEACAM5, HEG1, DCXR, PEAR1 and PCDH7, CEACAM5, FGA, PEPD, HEG1, TNC, PDIA4 and IL17RA, AREG, ADAM12, PK D1, DCXR, CEACAM5, NAGPA and LILRA4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and PCDH7, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and ADAMTSL4, ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, ITGA11 and HEG1, AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and CFP, ADAM12, CEACAM5, FGA, HEG1 , PDIA4, CD58 and FAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and HEG1, TNC, AGR3, MAMDC4, IL1RAP, TBCB, PDIA4 and MCAM, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and LILRA4, CEACAM5, SLAMF8, HEG1, DCXR, AGR3, GDF15 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and SERPI NA1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and MAMDC4, ADAM12, CEACAM5, FG A, HEG1, PDIA4, TBCB and MZB1, TNC, AGR3, MAMDC4, IL1RAP, TBCB, COMP and HEG1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB and COMP, SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC and CDH23, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and AGR3, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PRDX1. 4.TBCB and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and NCS1, TNC, AGR3, MAMDC4, IL1RAP, FGA, TBCB and HEG1,AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT 1 and RAB37, AREG, FGA, PEPD, HEG1, CEACAM5, ITGA11 and IL1RAP, AREG, ADAM12, PKD 1, DCXR, CEACAM5, CD34 and AGR3, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and NCS1, PDIA4, CEACAM5, MEGF9, PEPD, NCS1, AGR3 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and CDH23, CEACAM5, FGA, PEPD, HEG1, TBCB, MZB1 and IL1RAP, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and COMP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and LILRA4, SE RPINA1, CEACAM5, FGA, HEG1, MCAM, AGR3 and IL1RAP, ADAM12, CEACAM5, FGA, HE G1, PDIA4, AGR3 and FAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and CDH23, CE ACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4 and IL1RAP, AREG, FGA, PEPD, HEG1, CEAC AM5, PCDH7 and ESM1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and IL17RA, ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and PEAR1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and RTN4R, or AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and APOA4; Preferably, said A comprises an 8-markers combination, and said 8-markers combination is any eight of said B; Preferably, the 8 markers are combined into d1) and d2): d1) the 7 markers combination; d2) any one of the above B; Said d2) is different from any one of the markers in the combination of 7 markers in d1); Preferably, the 8 markers combination is: ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTS L4 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and LRCH4, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, SERPINA1 and PLXDC2, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and DCXR, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and HP GDS, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, NCS1 and C1QTNF1, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, PCDH7, FAP and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and SLAMF8, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, CDH23 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MCAM, AD AM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and ALCAM, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, SERPINA1 and HPGDS, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and MC AM, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and PKD1, ADAM12, CEA CAM5, FGA, HEG1, PDIA4, PCDH7, FAP and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and IL1RAP, ADAM 12. FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and CEACAM5, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and PEPD,ADAM12, CE ACAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and PKD1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, COMP and UPB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PC DH7 to IL1RAP, CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP to ASPN, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 to KHK, ADAM12, CEACAM5, FGA, HE G1, PDIA4, PCDH7, FAP and ALCAM, ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PCDH7 and C1QTNF1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and PLXDC2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 and IGFBP2, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, PEAR1 and IGFBP2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, IL17RA and IGFBP2, AREG, FGA, PEPD, HEG1, CEACAM5, CKB, IL1RAP and SER PINA1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and PKD1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and ASPN, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and CLEC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB 37 with NAGPA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 with CLEC3B, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM with IGFBP2, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP with PKD1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 with UPB1,AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, ESM1 and CANT1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and ALCAM, ADAM12, FGA, AGR3, IL1RAP, PRDX 1. PCDH7, HEG1 and CLEC3B, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and SSBP1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MCAM and PCDH7, ADAM 12. CEACAM5, FGA, HEG1, PDIA4, MAMDC4, FAP and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and UPB1, ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH 7, ADAMTSL4 and CFP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and IGFBP2, CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB, PEAR1 and CANT1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and KHK, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and TBCB, CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and SSC4D, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and SSBP1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, AGR3 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCD H7, FAP and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and MFGE8, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, RTN4R and CLEC3B,AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, PEAR1 and KRT19, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, C1QTNF1 and PEP D, AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, RAB37 and PCDH7, AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, ESM1 and SER PINA1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and PEPD, ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MAMDC4 and IL1RAP, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MFGE8, AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, I L1RAP and SSC4D, CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and IL17RA, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and CANT1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and CLEC3B, ADAM12, CEACAM5, FGA, HEG1, P DIA4, PCDH7, FAP and DCXR, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and MZB1, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and LRCH4, ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, PCDH7 and FAP, AREG, FGA, PEPD, HEG 1, CEACAM5, CANT1, PCDH7 and SERPINA1, ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and IGFBP2, AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, ITGA11 and PCDH7, ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, FAP and IL1RAP, ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, PEAR1 and IGFBP2,ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, MAMDC4, and IL1RAP, or ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM, and C1QTNF1.

4. The use according to any one of claims 1 to 3, characterized in that: Said A further comprises at least one of E, the union of said E and said A in any one of claims 1 to 3 is said B, and said E has no intersection with said A in any one of claims 1 to 3; Preferably, the test sample of the product is selected from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; Preferably, the body fluid comprises at least one of blood, lymph, pleural effusion, cerebrospinal fluid, joint fluid, ascites, saliva, lymph, and body fluid; Preferably, the tissue comprises intestinal mucosal tissue; Preferably, the blood comprises at least one of serum, plasma, dried blood spots, and whole blood; Preferably, the excreta comprises at least one of urine, feces, and tears; Preferably, the subject to be tested comprises a mammal; Preferably, the substance for detecting a marker comprises a substance for detecting a marker at the gene level and / or protein level; Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance, immuno-PCR, and biotin-avidin technology; Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation assay, flow cytometry fluorescence resolution, and single molecule detection technology; Preferably, the substance for detecting the marker is selected from: one or more of a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer; Preferably, the substance specific to the marker comprises any one of h1) to h4): h1) an antibody that specifically binds to the marker; h2) a ligand protein or polypeptide that specifically binds to the marker; h3) non-protein compounds that specifically recognize markers; h4) nucleic acid aptamers that specifically recognize markers; Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody; Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system; Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma; Preferably, the product further comprises auxiliary detection reagents for gene expression, and the auxiliary detection reagents for gene expression include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance; Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance. 5 . A marker combination comprising at least two of the Bs according to claim 1 .

6. The marker combination according to claim 5, characterized in that: The marker combination comprises any 2, 3, 4, 5, 6, 7, or 8 of the B in any one of claims 1 to 4; Preferably, the marker combination is A described in any one of claims 3 to 4.

7. A product comprising a substance for detecting the marker combination according to any one of claims 5 to 6.

8. The product according to claim 7, characterized in that: The substance for detecting the marker combination includes a substance for detecting the marker combination at the gene level and / or protein level; Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance, immuno-PCR, and biotin-avidin technology; Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation assay, flow cytometry fluorescence resolution, and single molecule detection technology; Preferably, the substance for detecting the marker combination is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer; Preferably, the substance specific to the marker comprises any one of h1) to h4): h1) an antibody that specifically binds to the marker; h2) a ligand protein or polypeptide that specifically binds to the marker; h3) non-protein compounds that specifically recognize markers; h4) nucleic acid aptamers that specifically recognize markers; Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody; Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system; Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma; Preferably, the product further comprises auxiliary detection reagents for gene expression, and the auxiliary detection reagents for gene expression include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance; Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

9. A method for constructing a model, comprising the step of constructing a model using the marker according to any one of claims 1 to 4.

10. The construction method according to claim 9, characterized in that: The method comprises the step of constructing a model using the marker combination according to claim 5 or 6; Preferably, the algorithm for constructing the model includes at least one of logarithmic regression, linear discriminant analysis, eigengene linear discriminant analysis, support vector machine, random forest, recursive partitioning tree, XGBoost, ShrunkenCentroids, StepAIC, Kth-Nearest Neighbor, Boosting, neural network, Bayesian network, and hidden Markov model.

11. A device or system comprising: Detection module: used to detect the content, activity and / or expression of the marker described in any one of claims 1 to 4 in the test sample; and Analysis module: used to input the data obtained by the detection module into the model constructed according to the construction method according to claim 9 or 10 for analysis.

12. The device or system according to claim 11, characterized in that: The detection module is used to detect the content, activity and / or expression of the marker combination according to claim 5 or 6 in the test sample; Preferably, the test sample is the test sample described in claim 4; Preferably, the device or system further comprises: an output module for outputting information according to the analysis results obtained by the analysis module.

13. A computer device comprising a memory and a processor, wherein the memory stores a program, and when the processor executes the program, it implements any one of the following methods i1) to i2): i1) A method for constructing a model according to claim 9 or 10; i2) S1: Obtaining the content, activity and / or expression of the marker according to any one of claims 1 to 4 in the test sample; and S2: Input the data acquired in S1 into the model constructed according to the construction method according to claim 9 or 10 for analysis.

14. The computer device according to claim 13, wherein: i2) S1 is to obtain the content, activity and / or expression of the marker combination according to claim 5 or 6 in the test sample; Preferably, the test sample is the test sample described in claim 4; Preferably, i2) further includes the following step: outputting information based on the obtained analysis results.

15. A computer readable storage medium comprising a stored computer program; wherein: When the computer program is running, the computer-readable storage medium is controlled to implement any one of the methods i1) to i2) in claim 13 or 14.

16. A method for distinguishing colorectal cancer from colorectal adenoma, comprising the step of detecting the content, expression level and / or activity of the marker according to any one of claims 1 to 4 in a test sample.

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