Composition containing enterotoxin C and application of composition in preparation of medicine with anti-tumor effect

By improving the composition and preparation method of enterotoxin C preparations, the problems of stability, targeting and versatility have been solved, the high efficiency and safety of tumor treatment have been achieved, the transportation and use costs have been reduced, and the scope of indications has been expanded.

CN120661536APending Publication Date: 2025-09-19SHENYANG XIEHE GRP LTD
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Patent Information

Application Number
CN202510645903.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-20
Publication Date
2025-09-19

AI Technical Summary

Technical Problem

Existing enterotoxin C preparations have significant bottlenecks in stability, targeting and versatility, resulting in poor effectiveness in tumor treatment. They also pose risks of pathogen contamination, high cold chain transportation costs, systemic immune storm risks and tumor microenvironment immunosuppression.

Method used

Whey protein, soy protein isolate or collagen is used as a stabilizer, combined with sodium chloride and mannitol to form a stable hydration layer, collagen peptides or whey peptides with a molecular weight of 500-5000 Da are used as penetration enhancers, resveratrol nanoliposomes are introduced for targeted delivery, astragalus polysaccharide and ginsenoside Rg3 are added to activate the immune pathway, the amino acid ratio is optimized to reduce toxicity, and enterotoxin C is purified by ion exchange chromatography.

Benefits of technology

It significantly improves the stability and activity retention of enterotoxin C, enhances tumor targeting and bioavailability, reduces systemic toxicity, increases the objective response rate of tumor treatment, and reduces transportation and usage costs.

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Abstract

The invention provides a composition containing enterotoxin C. The composition comprises the following components: 5-100 ng / mL of enterotoxin C; 0.1 to 5 mg / mL of protein, wherein the protein is selected from whey protein, soy protein isolate or collagen; the concentration of the polypeptide is 0.05 to 3 mg / mL, and the polypeptide is collagen peptide or whey peptide with the molecular weight of 500 to 5000 Da; 1.0 to 8.0 mg / mL of an amino acid mixture, wherein the amino acid mixture comprises 18 essential and non-essential amino acids. The enterotoxin C-containing composition disclosed by the invention realizes remarkable breakthrough in the aspects of stability, targeting property and multifunctionality through a multi-component synergistic effect and technical innovation.
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