Hawthorn chewable tablet with appetizing effect and preparation method thereof

Abstract

The invention relates to the technical field of health-care products, and discloses a hawthorn chewable tablet with an appetizing effect and a preparation method thereof.The hawthorn chewable tablet is formed by taking hawthorn powder as a main component and taking litsea cubeba essential oil coated freeze-dried powder, vitamin C, a flavoring agent and the like as auxiliary components through mixing, the Litsea cubeba essential oil can be adhered to the stomach wall to achieve the effect of continuously releasing the Litsea cubeba essential oil at a gastric ulcer target site, the antibacterial and anti-inflammatory effects of the Litsea cubeba essential oil can facilitate the repair of gastric tissues, and the Litsea cubeba essential oil can also regulate gastric acid secretion, so that further damage of excessive gastric acid to gastric mucosa is avoided; therefore, a good treatment effect on gastric ulcer is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of health care products, and in particular to a hawthorn chewable tablet with an appetizing effect and a preparation method thereof. Background Art

[0002] In modern society, the fast pace of life and unhealthy habits such as long-term overtime work and staying up late place a heavy burden on the digestive system. Furthermore, the increasing pressure of competition in modern society often puts people under high stress, and high mental stress can lead to gastrointestinal disorders. These problems are leading to an increasing number of people experiencing indigestion and loss of appetite. Furthermore, some patients with gastric ulcers often experience pain and discomfort due to damaged gastric mucosa, which irritates the ulcer surface when food enters the stomach. Western medicine is generally effective in treating indigestion and other problems, but its irritation and side effects make it unsuitable for long-term use. Traditional Chinese medicine, which mostly extracts its active ingredients from plants, is relatively mild and equally effective. However, its bitter and astringent taste is not to the taste of most people. This is why health supplements such as stomach-opening and digestive tablets have become increasingly popular.

[0003] Among the many appetite-stimulating and digestion-promoting tablets, hawthorn chewable tablets are highly representative. As a traditional Chinese medicine, they have been widely used to treat symptoms such as indigestion and loss of appetite since ancient times. However, existing hawthorn chewable tablets can only stimulate appetite and digestion by promoting intestinal peristalsis and enhancing the activity of pepsin. They have little effect on patients with gastric ulcers. Therefore, it is of great significance to develop hawthorn chewable tablets that can treat gastric ulcers. Summary of the Invention

[0004] In order to solve the problems mentioned in the background technology, the object of the present invention is to provide a hawthorn chewable tablet with an appetizing effect and a preparation method thereof.

[0005] The purpose of the present invention can be achieved through the following technical solutions: A method for preparing hawthorn chewable tablets with an appetizing effect, wherein the hawthorn chewable tablets are prepared from the following raw materials in parts by weight: 20-30 parts of hawthorn powder; 2-4 parts of Litsea cubeba essential oil-coated freeze-dried powder; Vitamin C 5-10 parts; 3-5 parts of seasoning; 15-25 parts of sodium carboxymethyl cellulose; 1-3 parts of magnesium stearate; The preparation method comprises the following steps: Step 1: Prepare sodium carboxymethyl cellulose mixture Mix sodium carboxymethyl cellulose with water, and mechanically stir at a stirring rate of 1000-1500 r / min to mix to form a mixed solution with a mass fraction of 15-25%; Step 2: Prepare hawthorn chewable tablets Hawthorn powder, lyophilized powder coated with essential oil of Litsea cubeba, vitamin C, and flavoring are stirred and evenly mixed, and then added to the mixed solution. After the addition, the mixture is shaken and evenly mixed. Then, magnesium stearate is added to the mixed solution under stirring to form a uniform suspension. The suspension is then dried at a temperature of 80-100° C. to a moisture content of 3-5%. The resulting material is then pulverized and passed through a 20-30 mesh sieve, and then tableted using a tablet press to obtain hawthorn chewable tablets.

[0006] As a further embodiment of the present invention, the freeze-dried powder coated with Litsea cubeba essential oil is prepared by the following method: Step 1: Prepare zein solution Add zein to the ethanol solution, start stirring, mix well, and prepare a zein solution with a mass fraction of 4-10%; In the above technical solution, since zein is insoluble in water and cannot be directly dissolved in anhydrous ethanol, studies have found that it has good solubility in ethanol-water solution, and its solubility is best in ethanol solution with a volume fraction of 60-70%. Therefore, an ethanol solution with a volume fraction of 60-70% is selected as a solvent to dissolve zein and prepare a zein solution.

[0007] Step 2: Prepare Litsea cubeba essential oil freeze-dried powder Adding the Litsea cubeba essential oil to the zein solution, mixing to form a mixture, then controlling the stirring rate to 4000-5000 r / min, adding water to the mixture while constantly stirring, and after addition, standing for 2-4 hours, and then freeze-drying to obtain Litsea cubeba essential oil freeze-dried powder; In the above technical solution, first, the wild pepper essential oil is mixed with the mixture to form a mixed liquid. At this time, a large amount of water is added to the mixed liquid to transform the solvent from a good solvent to a poor solvent, causing the hydrophilic end of the zein molecular chain to extend outward and the hydrophobic segment to extend inward, thereby generating an inner cavity structure. At this time, after the wild pepper essential oil in the poor solvent is precipitated, it will flow into the lipophilic inner cavity to achieve the encapsulation of the wild pepper essential oil. The mixture is then dried by a freeze-drying method to form a wild pepper essential oil freeze-dried powder.

[0008] Step 3: Preparation of Litsea cubeba essential oil-coated freeze-dried powder Dissolve chitosan in acetic acid solution with a mass fraction of 2% to prepare a chitosan solution, then add the freeze-dried powder of Litsea cubeba essential oil. After adding, stir evenly, then add calcium chloride, control the temperature to 50-60°C, stir for 1-3 hours, cool and discharge the material, and freeze-thaw cycles 2-4 times to obtain the freeze-dried powder coated with Litsea cubeba essential oil.

[0009] In the above technical solution, calcium chloride is used as a cross-linking agent and chitosan is used as a coating agent to further coat the freeze-dried powder of Litsea cubeba essential oil to obtain the Litsea cubeba essential oil-coated freeze-dried powder.

[0010] As a further embodiment of the present invention, in step 1, the volume fraction of the ethanol solution is 60-70%.

[0011] As a further embodiment of the present invention, in step 2, the volume ratio of the Litsea cubeba essential oil to the zein solution is 1:4-6.

[0012] As a further embodiment of the present invention, in step 2, the volume ratio of the mixed liquid to water is 1:3-6.

[0013] As a further solution of the present invention, in step three, the mass fraction of the chitosan solution is 20-30%.

[0014] In step three, As a further embodiment of the present invention, the flavoring agent is at least one of persimmon powder, lychee powder or grape powder.

[0015] A hawthorn chewable tablet with an appetizing effect is prepared by adopting the preparation method.

[0016] Beneficial effects of the present invention: The present invention prepares a freeze-dried powder coated with Litsea cubeba essential oil as an additive for chewable tablets. On the one hand, the coated Litsea cubeba essential oil is no longer easily volatile, so the medicinal efficacy can be retained for a long time. Moreover, the use of this coating structure can also solve the problem that Litsea cubeba essential oil is difficult to be compatible with other ingredients in the chewable tablet. On the other hand, because the outermost coating agent of the freeze-dried powder coated with Litsea cubeba essential oil is chitosan, which is difficult to dissolve in the neutral environment of the oral cavity, the Litsea cubeba essential oil is not released during the oral chewing process. However, the chitosan can dissolve under the acidic conditions of the stomach, and then the freeze-dried powder of Litsea cubeba essential oil inside is exposed. Through the biocompatibility of zein, it adheres to the stomach wall, achieving the effect of sustained release of Litsea cubeba essential oil at the target site of gastric ulcer. The antibacterial and anti-inflammatory effects of Litsea cubeba essential oil can help repair gastric tissue. In addition, Litsea cubeba essential oil can regulate gastric acid secretion, preventing further damage to the gastric mucosa caused by excessive gastric acid, thereby achieving a good therapeutic effect on gastric ulcer.

[0017] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. DETAILED DESCRIPTION

[0018] The following will be combined with the embodiments to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0019] Preparation Example 1 Preparation of Litsea cubeba essential oil-coated freeze-dried powder: Step 1: Prepare zein solution Add zein to a 65% ethanol solution, stir, and mix thoroughly to prepare a zein solution with a mass fraction of 8%; Step 2: Prepare Litsea cubeba essential oil freeze-dried powder 15 mL of Litsea cubeba essential oil was added to 80 mL of zein solution and mixed to form a mixture. The mixture was stirred at a rate of 5000 r / min and water was added to the mixture at a volume ratio of 1:4 under continuous stirring. After the addition, the mixture was allowed to stand for 3 h and then freeze-dried to obtain Litsea cubeba essential oil freeze-dried powder. Step 3: Preparation of Litsea cubeba essential oil-coated freeze-dried powder Chitosan was dissolved in 2% acetic acid solution to prepare 20 mL of 20% chitosan solution, and then 3 g of Litsea cubeba essential oil freeze-dried powder was added. After the addition, the mixture was stirred evenly, and then 0.5 g of calcium chloride was added. The temperature was controlled at 55°C, and after stirring for 2 hours, the mixture was cooled and discharged. After freeze-thaw cycles 3 times, the Litsea cubeba essential oil-coated freeze-dried powder was obtained.

[0020] Example 1 A hawthorn chewable tablet with an appetizing effect is prepared from the following raw materials in parts by weight: 20 parts of hawthorn powder; 2 parts of freeze-dried powder coated with Litsea cubeba essential oil; 5 parts of vitamin C; 3 parts persimmon powder; 15 parts of sodium carboxymethyl cellulose; 1 part of magnesium stearate; The preparation method comprises the following steps: Step 1: Prepare sodium carboxymethyl cellulose mixture Sodium carboxymethyl cellulose was mixed with water, and mechanically stirred at a stirring rate of 1000 r / min to form a mixed solution with a mass fraction of 20%; Step 2: Prepare hawthorn chewable tablets Hawthorn powder, lyophilized powder coated with essential oil of Litsea cubeba, vitamin C, and persimmon powder are stirred and evenly mixed, and then added to the mixed solution. After the addition, the mixture is shaken and evenly mixed. Then, magnesium stearate is added to the mixed solution under stirring to form a uniform suspension. The suspension is then dried at 80° C. to a moisture content of 4%. The resulting material is then pulverized and passed through a 30-mesh sieve. The material is then compressed using a tablet press to obtain hawthorn chewable tablets.

[0021] The preparation of the freeze-dried powder coated with the essential oil of Litsea cubeba is shown in Preparation Example 1, and the same applies to the following.

[0022] Example 2 A hawthorn chewable tablet with an appetizing effect is prepared from the following raw materials in parts by weight: 28 parts of hawthorn powder; 3.5 parts of Litsea cubeba essential oil-coated freeze-dried powder; 6 parts of vitamin C; 4 parts lychee powder; 18 parts of sodium carboxymethyl cellulose; 2 parts of magnesium stearate; The preparation method comprises the following steps: Step 1: Prepare sodium carboxymethyl cellulose mixture Sodium carboxymethyl cellulose was mixed with water, and mechanically stirred at a stirring rate of 1200 r / min to form a mixed solution with a mass fraction of 20%; Step 2: Prepare hawthorn chewable tablets Hawthorn powder, lychee essential oil-coated freeze-dried powder, vitamin C, and lychee powder are stirred and evenly mixed, and then added to the mixed solution. After the addition is completed, the mixture is shaken and evenly mixed. Then, magnesium stearate is added to the mixed solution under stirring to form a uniform suspension. The suspension is then dried at 80° C. to a moisture content of 4%. The resulting material is then pulverized and passed through a 30-mesh sieve, and then tableted using a tablet press to obtain hawthorn chewable tablets.

[0023] Example 3 A hawthorn chewable tablet with an appetizing effect is prepared from the following raw materials in parts by weight: 30 parts of hawthorn powder; 4 parts of freeze-dried powder coated with Litsea cubeba essential oil; Vitamin C 10 parts; 5 parts grape powder; 25 parts of sodium carboxymethyl cellulose; 3 parts of magnesium stearate; The preparation method comprises the following steps: Step 1: Prepare sodium carboxymethyl cellulose mixture Sodium carboxymethyl cellulose was mixed with water, and mechanically stirred at a stirring rate of 1500 r / min to form a mixed solution with a mass fraction of 20%; Step 2: Prepare hawthorn chewable tablets Hawthorn powder, lyophilized powder coated with essential oil of Litsea cubeba, vitamin C, and grape powder are stirred and evenly mixed, and then added to the mixed solution. After the addition, the mixture is shaken and evenly mixed. Then, magnesium stearate is added to the mixed solution under stirring to form a uniform suspension. The suspension is then dried at 80° C. to a moisture content of 4%. The resulting material is then pulverized and passed through a 30-mesh sieve. The material is then compressed using a tablet press to obtain hawthorn chewable tablets.

[0024] Comparative Example 1 A hawthorn chewable tablet with an appetizing effect, which differs from Example 2 in that the freeze-dried powder coated with Litsea cubeba essential oil is replaced with Litsea cubeba essential oil, and the rest remains unchanged.

[0025] Comparative Example 2 A hawthorn chewable tablet with an appetizing effect, which differs from Example 2 in that the freeze-dried powder coated with the essential oil of Litsea cubeba is removed, while the rest remains unchanged.

[0026] Test Case 120 rats weighing 50±1 g were randomly selected and divided into 6 groups with 20 rats in each group, namely Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and blank experimental group. After being raised with standard feed and drinking water for 7 days in the same laboratory environment, the experiment was carried out. The rats were deprived of food intake one day before the start of the experiment. After anesthesia, the rats were opened and 10% acetic acid solution was injected at 0.4 mm below the serosal membrane at the junction of the pyloric antrum and the gastric body to produce an acute gastric ulcer model. After 60 seconds of contact with the anterior wall serosal membrane, the stomach clamp was removed, and the stomach was replaced after washing with normal saline. The incision was sutured and disinfected. One day after the operation, the rats were gavaged with hawthorn chewable tablets of the corresponding group once a day for two consecutive weeks. One day after the last gavage, the rats were killed, the stomach was removed, and the stomach was immersed in 10% formaldehyde solution to fix the serosal layer. The stomach was cut open and the residue was removed. The stomach was then unfolded and the maximum transverse diameter X and longitudinal diameter Y through the center of the ulcer were measured. The two were multiplied and recorded as the gastric ulcer index. The test results are recorded in Table 1. ● Compared with the blank group, P < 0.05: Table 1 Test results

[0027] The analysis and test results show that the hawthorn chewable tablets prepared in Examples 1 to 3 of the present invention have good therapeutic effects on gastric ulcers. However, after replacing the lyophilized powder coated with the essential oil of Litsea cubeba with Litsea cubeba essential oil, on the one hand, the volatile Litsea cubeba essential oil is high, and a large amount of volatilization occurs during storage, resulting in reduced efficacy. In addition, the essential oil of Litsea cubeba cannot stay in the stomach, and most of it is excreted from the body with feces, resulting in a low utilization rate. Therefore, the prepared hawthorn chewable tablets have poor efficacy for gastric ulcers. After directly removing the lyophilized powder coated with the essential oil of Litsea cubeba, the advantages of the essential oil of Litsea cubeba cannot be utilized, and thus the efficacy of the prepared hawthorn chewable tablets for gastric ulcers is further reduced.

[0028] Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core ideas, including the best mode, and also enable any technician in the field to practice the present invention, including making and using any device or system, and implementing any combined method. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention. The scope of patent protection of the present invention is defined by the claims and may include other embodiments that can be thought of by those skilled in the art. If these other embodiments have structural elements similar to the literal description of the claims, or if they include equivalent structural elements that are not substantially different from the literal description of the claims, then these other embodiments should also be included in the scope of the claims.

Claims

1. A method for preparing hawthorn chewable tablets with an appetizing effect, characterized in that: The hawthorn chewable tablets are made from the following raw materials in parts by weight: 20-30 parts of hawthorn powder; 2-4 parts of Litsea cubeba essential oil-coated freeze-dried powder; Vitamin C 5-10 parts; 3-5 parts of seasoning; 15-25 parts of sodium carboxymethyl cellulose; 1-3 parts of magnesium stearate; The preparation method comprises the following steps: Step 1: Prepare sodium carboxymethyl cellulose mixture Mix sodium carboxymethyl cellulose with water, and mechanically stir at a stirring rate of 1000-1500 r / min to mix to form a mixed solution with a mass fraction of 15-25%; Step 2: Prepare hawthorn chewable tablets Hawthorn powder, lyophilized powder coated with essential oil of Litsea cubeba, vitamin C, and flavoring are stirred and evenly mixed, and then added to the mixed solution. After the addition, the mixture is shaken and evenly mixed. Then, magnesium stearate is added to the mixed solution under stirring to form a uniform suspension. The suspension is then dried at a temperature of 80-100° C. to a moisture content of 3-5%. The resulting material is then pulverized and passed through a 20-30 mesh sieve, and then tableted using a tablet press to obtain hawthorn chewable tablets.

2. The method for preparing a hawthorn chewable tablet with an appetizing effect according to claim 1, characterized in that: The Litsea cubeba essential oil-coated freeze-dried powder is prepared by the following method: Step 1: Prepare zein solution Add zein to the ethanol solution, start stirring, mix thoroughly, and prepare a zein solution with a mass fraction of 4-10%; Step 2: Prepare Litsea cubeba essential oil freeze-dried powder Adding the Litsea cubeba essential oil to the zein solution, mixing to form a mixture, then controlling the stirring rate to 4000-5000 r / min, adding water to the mixture while constantly stirring, and after addition, standing for 2-4 hours, and then freeze-drying to obtain Litsea cubeba essential oil freeze-dried powder; Step 3: Preparation of Litsea cubeba essential oil-coated freeze-dried powder Dissolve chitosan in acetic acid solution with a mass fraction of 2% to prepare a chitosan solution, then add the freeze-dried powder of Litsea cubeba essential oil. After adding, stir evenly, then add calcium chloride, control the temperature to 50-60°C, stir for 1-3 hours, cool and discharge the material, and freeze-thaw cycles 2-4 times to obtain the freeze-dried powder coated with Litsea cubeba essential oil.

3. The method for preparing a hawthorn chewable tablet with an appetizing effect according to claim 2, characterized in that: In step 1, the volume fraction of the ethanol solution is 60-70%.

4. The method for preparing a hawthorn chewable tablet with an appetizing effect according to claim 2, characterized in that: In step 2, the volume ratio of the Litsea cubeba essential oil to the zein solution is 1:4-6.

5. The method for preparing a hawthorn chewable tablet with an appetizing effect according to claim 2, characterized in that: In step 2, the volume ratio of the mixed solution to water is 1:3-6.

6. The method for preparing a hawthorn chewable tablet with an appetizing effect according to claim 2, characterized in that: In step 3, the mass fraction of the chitosan solution is 20-30%.

7. The method for preparing the hawthorn chewable tablets with an appetizing effect according to claim 1, characterized in that: The flavoring agent is at least one of persimmon powder, lychee powder or grape powder.

8. A hawthorn chewable tablet with an appetizing effect, characterized in that: The method is as described in any one of claims 1 to 7.

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