Traditional Chinese medicine hydrogel eye pad for relieving eyestrain and preparation method of traditional Chinese medicine hydrogel eye pad

Abstract

The invention provides a traditional Chinese medicine hydrogel eye pad for relieving eyestrain and a preparation method thereof, and belongs to the technical field of hydrogel eye pads. The traditional Chinese medicine hydrogel eye patch comprises lutein microcapsules, astaxanthin microcapsules, a centella asiatica extract, natural borneol, a dogwood extract, a humectant, a solubilizer and a gelatinizing agent, the preparation method is as follows; the preparation method comprises the following steps: uniformly fusing and mixing sieved lutein, astaxanthin, centella asiatica extract, cassia seed extract, natural borneol, dogwood extract and a solubilizer at 50 DEG C, adding the mixture and a hyaluronic acid aqueous solution into a polyvinyl alcohol aqueous solution, and uniformly mixing; the preparation method comprises the following steps: firstly, preparing hydrogel by using a non-woven fabric as a raw material, then degassing, filling and freezing to obtain hydrogel, attaching the prepared hydrogel to the inner surface of the non-woven fabric, and covering the other surface of the hydrogel with a polyvinyl chloride film to obtain the hydrogel eye pad, and the prepared hydrogel eye pad has the advantages of long-acting moisturizing, slow-release synergistic effect, comfortable attachment, safety and no irritation.

Description

Technical Field

[0001] The invention belongs to the technical field of hydrogel eye patches, and particularly relates to a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue and a preparation method thereof. Background Art

[0002] With the rapid development of information technology, electronic screens have deeply permeated every aspect of human life. Prolonged use of devices like smartphones, computers, and tablets has significantly increased the average daily eye strain of modern people. According to statistics, approximately 60% of adults worldwide use electronic devices for more than six hours per day, and this figure rises to 80% among adolescents. This high-intensity, high-frequency use of the eyes leads to frequent eye fatigue, dryness, blurred vision, and even accelerates the progression of conditions such as myopia and glaucoma. Furthermore, environmental factors (such as blue light radiation and air pollution) and lifestyle changes (staying up late and lacking sleep) further exacerbate oxidative stress and metabolic disorders in the eyes. Research has shown that blue light (wavelength 400-500 nm) can penetrate the cornea and lens, directly damaging retinal pigment epithelial cells, inducing the accumulation of free radicals, and increasing the risk of macular degeneration. Chronic visual fatigue can lead to problems such as impaired ocular microcirculation, decreased tear secretion, and decreased corneal sensitivity, forming a vicious cycle that urgently requires safe and effective interventions.

[0003] Currently, the products available on the market for relieving eye fatigue mainly include artificial tears, steam eye masks, and ordinary gel patches. However, these products generally have the following shortcomings: (1) Single function: Most products only relieve symptoms through physical cooling or temporary moisturizing, and lack a synergistic repair mechanism for blue light damage, oxidative stress, and inflammatory response; (2) Ingredient limitations: Chemically synthesized ingredients (such as polyvinyl alcohol eye drops) may cause irritation or dependence, while traditional Chinese medicine eye patches mostly use crude extracts, with low active ingredient permeability and poor stability; (3) Dosage form defects: Ordinary patches are not moisturizing enough and cannot maintain a moist environment in the eyes for a long time, and they have poor adhesion and are easy to fall off. Therefore, the development of an eye patch that integrates modern pharmacology and new formulation technology, and has the comprehensive effects of antioxidant, anti-inflammatory, circulation-promoting and moisturizing functions, has become a key breakthrough in solving contemporary eye health problems. Summary of the Invention

[0004] In view of the problems in the prior art, the present invention provides a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue and a preparation method thereof.

[0005] In order to achieve the above objectives, the technical solutions adopted in this application are: In a first aspect, a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue comprises the following raw materials in parts by mass: 10-50 parts of lutein microcapsules, 1-5 parts of astaxanthin microcapsules, 10-30 parts of Centella asiatica extract, 20-50 parts of Cassia seed extract, 1-3 parts of natural borneol, 10-30 parts of Cornus officinalis extract, 55-120 parts of moisturizing agent, 10-30 parts of solubilizing agent, and 55-120 parts of gelling agent. The gelling agent includes one or more of polyvinyl alcohol and hyaluronic acid.

[0006] Preferably, the moisturizing agent includes one or more of 1,3-propylene glycol glycerol and sodium hyaluronate.

[0007] Preferably, the solubilizer includes one or more of PEG40 hydrogenated castor oil, PEG60 hydrogenated castor oil, and SuperRefinedTMP35 castor oil.

[0008] Preferably, the polyvinyl alcohol includes one or more of polyvinyl alcohol with a molecular weight of 30-70 KD, polyvinyl alcohol with a molecular weight of 85-130 KD, and polyvinyl alcohol with a molecular weight of 130-200 KD.

[0009] In the second aspect, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue is provided, wherein the specific preparation method is as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is β-cyclodextrin; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, Cassia seed extract, Cornus officinalis extract and natural borneol according to the above raw material composition ratio and pass through a 60-100 mesh sieve; Step 3: Add deionized water to the first beaker, then heat the deionized water to 85-95°C, then add polyvinyl alcohol and stir continuously until completely dissolved; after dissolution is complete, add deionized water to the first beaker to prepare a polyvinyl alcohol aqueous solution with a mass fraction of 15%-25%, and set aside; Step 4: Add deionized water to the second beaker, then add hyaluronic acid, stir until completely dissolved, then add deionized water to the second beaker to prepare a hyaluronic acid aqueous solution with a mass fraction of 1%-2%, set aside; Step 5: Add deionized water to the third beaker, then add a solubilizer, and heat to 50°C. Then, add lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, Cassia seed extract, natural borneol, Cornus officinalis extract, and moisturizer in sequence, and fully dissolve them to obtain a Chinese medicine mixture; Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly to obtain a mixed solution; Step 7: placing the mixed solution in a vacuum degassing device for degassing to obtain a degassed solution; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product is subjected to a -20°C freeze-thaw treatment 3-5 times at room temperature to prepare a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by irradiation.

[0010] Preferably, in step seven, the vacuum degassing device is set to a pressure of 5-10 kPa.

[0011] Preferably, in step 11, cobalt-60 irradiation sterilization is used.

[0012] Compared with the prior art, the advantages and positive effects of the present invention are: The present application discloses a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue and a preparation method thereof. The traditional Chinese medicine hydrogel eye patch comprises: lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, natural borneol, Cornus officinalis extract, a moisturizer, a solubilizer, and a gelling agent. The preparation method comprises: fusing and uniformly mixing the sieved lutein, astaxanthin, Centella asiatica extract, Cassia seed extract, natural borneol, Cornus officinalis extract, and a solubilizer at 50° C., adding the mixture together with a hyaluronic acid aqueous solution to a polyvinyl alcohol aqueous solution and uniformly mixing; then degassing, filling, and freezing the mixture to obtain a hydrogel, attaching the obtained hydrogel to the inner surface of a non-woven fabric, and covering the other side of the hydrogel with a polyvinyl chloride film to obtain the hydrogel eye patch. In addition, this eye patch contains lutein, which can absorb blue light and reduce the damage of blue light to the retina, which helps prevent the occurrence and development of myopia. At the same time, astaxanthin, Centella asiatica extract, Cassia seed extract, Cornus officinalis extract, and natural borneol are added; they can scavenge free radicals and protect eye cells from oxidative damage, while clearing heat and toxins from the eyes, improving blood circulation in the eyes, and reducing eye fatigue and dryness, which also has a certain auxiliary effect in preventing myopia. The above drugs were combined to prepare a gel eye patch, and its antioxidant capacity, blue light protection capacity, and moisturizing properties were studied. The results showed that the hydrogel eye patch has obvious antioxidant, blue light protection, and moisturizing properties, and has the function of preventing myopia and relieving eye fatigue. Finally, the hydrogel eye patch of this application uses microencapsulation technology (lutein and astaxanthin) to enhance the stability of photothermosensitive ingredients and control the slow release of active ingredients, extending the duration of action. Using polyvinyl alcohol as a gelling agent, the gel, prepared via a freeze-thaw physical crosslinking method, is soft and breathable, perfectly conforming to the eye contour and avoiding the pressure of traditional patches. All raw materials meet pharmaceutical or food-grade standards, are irradiated and sterilized, and contain no preservatives, making it suitable for people with sensitive skin. This product is not only suitable for office workers, students, and other long-term eye users, but can also serve as an auxiliary means of preventing and controlling myopia. Compared to competing products with single functions, this invention, through its integrated "protection-repair-nourishment" design, meets consumers' urgent demand for efficient, convenient, and natural eye care products and has broad industrial prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0014] Figure 1 This is a physical picture of the hydrogel eye patch of the present invention; Figure 2 The graph shows the change in the moisturizing rate of the hydrogel eye patch of Examples 3, 4, 5 and 6 of the present invention over time. DETAILED DESCRIPTION

[0015] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features therein can be combined with each other without conflict.

[0016] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0017] The present application discloses a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the raw materials thereof are as follows in parts by mass: 10-50 parts of lutein, 1-5 parts of astaxanthin, 10-30 parts of Centella asiatica extract, 20-50 parts of Cassia seed extract, 1-3 parts of natural borneol, 10-30 parts of Cornus officinalis extract, 55-125 parts of moisturizing agent, 10-30 parts of solubilizing agent, and 55-120 parts of gelling agent. The gelling agent includes one or more of polyvinyl alcohol or hyaluronic acid; The moisturizing agent includes 1,3-butylene glycol, 1,3-propylene glycol glycerol, sodium hyaluronate, preferably one or more of glycerol and sodium hyaluronate; The solubilizer includes one or more of PEG40 hydrogenated castor oil (C040), PEG60 hydrogenated castor oil (C060), and SuperRefined™ P35 castor oil; The polyvinyl alcohol includes polyvinyl alcohol with a molecular weight of 30-70 KD (specific model PVA 05-88), polyvinyl alcohol with a molecular weight of 85-130 KD (specific model PVA 17-88) and polyvinyl alcohol with a molecular weight of 130-200 KD (specific model PVA24-88).

[0018] The present application discloses a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue. The specific preparation method is as follows: Step 1: Weigh lutein, astaxanthin, Centella asiatica extract, Cassia seed extract, Cornus officinalis extract and natural borneol according to the above raw material composition ratio and pass through a 60-100 mesh sieve; Step 2: Encapsulating lutein and astaxanthin using microencapsulation method, using β-cyclodextrin as the encapsulation material; Step 3: Add deionized water to the first beaker, then heat the deionized water to 85-95°C, then add polyvinyl alcohol and stir continuously until completely dissolved; after dissolution is complete, add deionized water to the first beaker to prepare a polyvinyl alcohol aqueous solution with a mass fraction of 15%-25%, and set aside; Step 4: Add deionized water to the second beaker, then add hyaluronic acid, stir until completely dissolved, then add deionized water to the second beaker to prepare a hyaluronic acid aqueous solution with a mass fraction of 1%-2%, set aside; Step 5: Add deionized water to the third beaker, then add a solubilizer, and heat to 50°C. Then, add lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, Cassia seed extract, natural borneol, Cornus officinalis extract, glycerin, and sodium hyaluronate in sequence, and fully dissolve to obtain a traditional Chinese medicine mixture; Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the vacuum degassing device is set to a pressure of 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product is subjected to a -20°C freeze-thaw treatment 3-5 times at room temperature to prepare a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by irradiation.

[0019] Example 1, as Figure 1 As shown, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 1 g of lutein microcapsules, 0.1 g of astaxanthin microcapsules, 1 g of Centella asiatica extract, 2 g of Cassia seed extract, 1 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of 85-130 kD polyvinyl alcohol, and finally set the speed to 600 rpm in a magnetic stirrer and stir continuously until completely dissolved; after the dissolution is complete, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; the reason for choosing 85-130 kD polyvinyl alcohol is that it has moderate mechanical strength, is not easy to deform, and has good swelling properties; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 hydrogenated castor oil, and heat to 50°C. Then, add 1 g of lutein microcapsules, 0.1 g of astaxanthin microcapsules, 1 g of Centella asiatica extract, 2 g of Cassia seed extract, 0.3 g of natural borneol, 1 g of Cornus officinalis extract, and a moisturizer including 2 g of sodium hyaluronate and 10 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the modulation parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0020] Example 2, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 3 g of lutein microcapsules, 0.3 g of astaxanthin microcapsules, 2 g of Centella asiatica extract, 3 g of Cassia seed extract, 2 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 30-70 KD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 3 g of lutein microcapsules, 0.3 g of astaxanthin microcapsules, 2 g of Centella asiatica extract, 3 g of Cassia seed extract, 2 g of Cornus officinalis extract, 0.3 g of natural borneol, and a moisturizer including 2 g of sodium hyaluronate and 10 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0021] Example 3, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 130-200 kD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, 0.3 g of natural borneol, and a moisturizer including 2 g of sodium hyaluronate and 10 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0022] Example 4, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 130-200 kD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, 0.3 g of natural borneol, and a moisturizer including 1 g of sodium hyaluronate and 8 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0023] Example 5, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 85-130 kD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, 0.3 g of natural borneol, and a moisturizer including 0.5 g of sodium hyaluronate and 5 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0024] Example 6, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, wherein the encapsulation material is food grade or pharmaceutical grade; preparing lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 85-130 kD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 5 g of lutein microcapsules, 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol in sequence and fully dissolve them to obtain a traditional Chinese medicine mixture; Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0025] Example 7, a method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue, wherein the specific preparation steps are as follows: Step 1: Encapsulating astaxanthin using a microencapsulation method, using food grade or pharmaceutical grade materials to prepare astaxanthin microcapsules; Step 2: Weigh 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, and 0.3 g of natural borneol, and then pass through an 80-mesh sieve; Step 3: Add 100 mL of deionized water to the first beaker, then heat the deionized water to 95°C, then add 25 g of polyvinyl alcohol with a molecular weight of 30-70 KD, and stir continuously at a set speed of 600 rpm until completely dissolved; after dissolution, add deionized water to the first beaker to prepare a 25% mass fraction polyvinyl alcohol aqueous solution for later use; Step 4: Add 100 mL of deionized water to a second beaker, followed by 2 g of sodium hyaluronate. Stir until completely dissolved, then add deionized water to the second beaker to prepare a 2% hyaluronic acid aqueous solution for later use. Step 5: Add deionized water to the third beaker, followed by Super Refined™ P35 castor oil, and heat to 50°C. Then, add 0.5 g of astaxanthin microcapsules, 3 g of Centella asiatica extract, 5 g of Cassia seed extract, 3 g of Cornus officinalis extract, 0.3 g of natural borneol, and a moisturizer including 2 g of sodium hyaluronate and 10 g of 1,3-propylene glycol glycerol, and fully dissolve them to obtain a traditional Chinese medicine mixture. Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly for 10 minutes to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degassing device for degassing to remove bubbles in the solution to prevent the eye patch from affecting the fit and comfort during use due to bubbles; obtain a degassed solution; the parameters of the vacuum degassing device are controlled at 5-10 kPa; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product was subjected to five freeze-thaw treatments at -20°C and thawed at room temperature, with each freezing time of 6 hours and each room temperature storage time of 2 hours to obtain a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film as an isolation layer to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by cobalt-60 irradiation.

[0026] Evaluation of antioxidant properties: To evaluate the antioxidant effects of lutein, astaxanthin, Centella asiatica extract, Cassia seed extract, and Cornus officinalis extract, this study examined the antioxidant capacity of the above-mentioned prescriptions at different contents in Examples 1-3 through DPPH free radical scavenging experiments.

[0027] Sample preparation: Take 1 cm 2 of the hydrogel eye patch prepared in Examples 1, 2, 3, and 7 respectively. 2, chop it into pieces, add 2 mL of anhydrous ethanol, sonicate and let it stand for 30 min, then centrifuge at 5000 rpm for 10 min, and take the supernatant for use.

[0028] Preparation of vitamin C solution: Prepare vitamin C to a concentration of 0.1 mg / mL as a positive control.

[0029] Preparation of DPPH solution: Prepare DPPH solution with anhydrous ethanol to a concentration of 0.1 mM.

[0030] Separately take the above-prepared supernatant, vitamin C solution, and DDPH solution and mix them according to the following method; There are four groups: Group 1: Sample background: 100 μL sample solution + 100 μL ethanol; Group 2: negative control: 100 μL ethanol + 100 μL DDPH; Group 3: Experimental group (including Examples 1-3): 100 μL sample solution + 100 μL DDPH; Group 4: Positive control group: 100 μL vitamin C + 100 μL DDPH.

[0031] The mixed samples of each group were kept in the dark for 30 min, and their absorbance was measured at 570 nm and the clearance rate was calculated. The calculation formula of clearance rate is as follows: Clearance rate (%) = [1-(A 实验组 -A 样品背景组 ) / A 空白组 ]×100%; where A is the absorbance value at 570 nm; The results are shown in Table 1 below. Table 1 Antioxidant test results of hydrogel eye patch

[0032] As shown in Table 1 above, as more antioxidant components are added to the hydrogel eye patch, its ability to scavenge free radicals becomes stronger, and Example 3 has the best antioxidant performance; Evaluation of blue light protection performance: 1 cm2 of the hydrogel eye patches prepared in Examples 1, 2, 3, and 7 were cut into pieces and placed in the light path. The intensity of the transmitted light at 450 nm was measured and recorded using a spectrophotometer, and the transmittance and blue light blocking rate were calculated. The results are shown in Table 2 below. Table 2 Test results of blue light transmittance and blocking rate of each hydrogel eye patch

[0033] As shown in Table 2 above, Example 7 does not contain lutein, and its eye gel has a high blue light transmittance and a weak blue light blocking ability. In contrast, in Examples 1-3, as the lutein content in the prescription increases, its blue light transmittance gradually decreases, indicating that its blue light blocking ability is stronger. Therefore, adding lutein to the prescription can improve the blue light blocking ability and thus prevent myopia. Test on the moisturizing ability of glycerin and sodium hyaluronate: Since different doses of glycerin and sodium hyaluronate were added in Examples 3, 4, 5, and 6, the hydrogel eye patches of Examples 3, 4, 5, and 6 were cut into 2 cm 2 Record the mass W0 of each small piece of equal size; then place it in a dry watch glass and place it in a constant temperature and humidity chamber (temperature 25°C, humidity 50% RH). After 0.5, 1, 2, 4, 6, 8, 12, and 24 hours, take out the sample, weigh it quickly, and record W t , and then put it back immediately; at the same time, take the same sample and place it in an oven at 40°C to dry to constant weight, which is the weight after drying W dry , calculate the moisture residual rate by weight change, the structure is as follows Table 3 and Figure 2 As shown; The formula for calculating the moisturizing rate is as follows: Moisturizing rate (%) = [(W t -W dry ) / (W0-W dry )]×100%; Table 3 Test results of moisturizing rate of hydrogel eye patches of Examples 3, 4, 5, and 6

[0034] Clinical efficacy test: 90 subjects aged 18-40 who use their eyes regularly were selected for a 21-day study. The hydrogel eye patches of Examples 1, 2, and 3 were used daily, with regular diet and daily morning and evening application. No other eye products were used during the study period. Symptom improvement included: sore eyes, eye swelling, photophobia, blurred vision, dry eyes, foreign body sensation, tearing, conjunctival congestion, and general discomfort. Improvement of four of the nine symptoms, with no worsening of other symptoms, was considered effective. The symptom improvement rate was calculated using the following formula, as shown in Table 4: Effective rate of symptom improvement (%) = (effective number of people / total number of people) × 100%; Table 4 Statistical results of the effectiveness of the hydrogel eye patches for improving symptoms in Examples 1, 2, and 3

[0035] The subjects underwent comparative visual function testing using a flip-snap on days 0 and 21, respectively. The speed of the eye's response to varying levels of accommodation stimulation was measured. The accommodation stimulation alternated between two different levels. After each change in accommodation stimulation, the subjects immediately reported when the visual target became clear, and the number of flips per minute was calculated. The results are shown in Table 5 below. Before use, the average number of flips per minute for each of the 90 subjects was 6-8. After 21 days of use, the number of flips per minute for accommodation sensitivity in both eyes increased to varying degrees. Therefore, the use of the hydrogel eye patch significantly improved the eye's accommodation sensitivity, indicating that the hydrogel helps improve visual function.

[0036] Table 5 Statistics of the number of times the experimenters used flip shots

[0037] The above description is merely a preferred embodiment of the present invention and does not limit the present invention in any other form. Any technician familiar with the present invention may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes for application in other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention shall still fall within the scope of protection of the technical solution of the present invention.

Claims

1. A Chinese medicine hydrogel eye patch for relieving eye fatigue, characterized in that: The raw material composition is as follows in parts by mass: 10-50 parts of lutein microcapsules, 1-5 parts of astaxanthin microcapsules, 10-30 parts of Centella asiatica extract, 20-50 parts of Cassia seed extract, 1-3 parts of natural borneol, 10-30 parts of Cornus officinalis extract, 55-120 parts of moisturizing agent, 10-30 parts of solubilizing agent and 55-120 parts of gelling agent; The gelling agent includes one or more of polyvinyl alcohol and hyaluronic acid.

2. A Chinese medicine hydrogel eye patch for relieving eye fatigue according to claim 1, characterized in that: The moisturizing agent includes one or more of 1,3-propylene glycol glycerol and sodium hyaluronate.

3. The Chinese medicine hydrogel eye patch for relieving eye fatigue according to claim 1, characterized in that: The solubilizers include PEG40 hydrogenated castor oil, PEG60 hydrogenated castor oil, Super Refined TM P35 One or more castor oils.

4. The Chinese medicine hydrogel eye patch for relieving eye fatigue according to claim 1, characterized in that: The polyvinyl alcohol includes one or more of polyvinyl alcohol with a molecular weight of 30-70 KD, polyvinyl alcohol with a molecular weight of 85-130 KD, and polyvinyl alcohol with a molecular weight of 130-200 KD.

5. The method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue according to any one of claims 1 to 4, characterized in that: Its specific preparation method is as follows: Step 1: Encapsulating lutein and astaxanthin using a microencapsulation method, using β-cyclodextrin as the encapsulation material to prepare lutein microcapsules and astaxanthin microcapsules; Step 2: Weigh lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, Cassia seed extract, Cornus officinalis extract and natural borneol according to the above raw material composition ratio and pass through a 60-100 mesh sieve; Step 3: Add deionized water to the first beaker, then heat the deionized water to 85-95°C, then add polyvinyl alcohol and stir continuously until completely dissolved; after dissolution is complete, add deionized water to the first beaker to prepare a polyvinyl alcohol aqueous solution with a mass fraction of 15%-25%, and set aside; Step 4: Add deionized water to the second beaker, then add hyaluronic acid, stir until completely dissolved, then add deionized water to the second beaker to prepare a hyaluronic acid aqueous solution with a mass fraction of 1%-2%, set aside; Step 5: Add deionized water to the third beaker, then add a solubilizer, and heat to 50°C. Then, add lutein microcapsules, astaxanthin microcapsules, Centella asiatica extract, Cassia seed extract, natural borneol, Cornus officinalis extract, and moisturizer in sequence, and fully dissolve them to obtain a Chinese medicine mixture; Step 6: Add the traditional Chinese medicine mixture and the hyaluronic acid aqueous solution to the polyvinyl alcohol aqueous solution, and stir thoroughly to obtain a mixed solution; Step 7: Place the mixed solution in a vacuum degasser for degassing; Obtaining a degassed solution; Step 8: Pour the degassed solution into the eye patch mold and shake the mold to evenly cover every corner of the mold with the solution. Then place the mold on a flat surface and let it stand to obtain the filled product. Step 9: Using the freeze-thaw physical crosslinking method, the filled product is subjected to a -20°C freeze-thaw treatment 3-5 times at room temperature to prepare a hydrogel; Step 10: attaching the hydrogel to the inner surface of the non-woven fabric and covering the other side of the hydrogel with a polyvinyl chloride film to obtain a hydrogel eye patch; Step 11: Package the prepared hydrogel eye patch and sterilize it by irradiation.

6. The method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue according to claim 5, characterized in that: In step seven, the pressure of the vacuum degassing device is set to 5-10 kPa.

7. The method for preparing a traditional Chinese medicine hydrogel eye patch for relieving eye fatigue according to claim 5, characterized in that: In step 11, cobalt-60 irradiation is used for sterilization.

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