Extracorporeal circulation integrated pipeline structure of extracorporeal membrane lung oxygenator

Abstract

The extracorporeal circulation integrated pipeline structure comprises a membrane type oxygenator body, one end of the membrane type oxygenator body is provided with a first vein backflow end, and the first vein backflow end and the end of the membrane type oxygenator body are integrally formed. The first vein backflow end is provided with an integrally-formed first vein backflow pipe, the other end of the membrane type oxygenator body is provided with a second vein backflow end, and the second vein backflow end is provided with an integrally-formed second vein backflow pipe; pressure control valve bodies are arranged on the first venous return pipe and the second venous return pipe, each pressure control valve body comprises a valve seat, a stepped threaded section is arranged on one side of each valve seat, a multi-stage self-sealing structure is further arranged in each valve seat, and each valve seat is detachably connected with a CRRT pipeline connector. Meanwhile, the on-machine time is shortened, the treatment cost of a patient is reduced, and the valve seat can be automatically opened and subjected to multi-stage sealing.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to an extracorporeal circulation integrated pipeline structure of an extracorporeal membrane oxygenator. Background Art

[0002] Extracorporeal membrane oxygenation (ECMO) represents the most advanced technology in extracorporeal circulation equipment. It is a high-end medical device for critical care. Its research and development involves multiple disciplines, including biomechanics, fluid mechanics, mechanical engineering, biomaterials, and medicine. It exemplifies the integration of medicine and engineering, a multidisciplinary cross-cutting approach that presents significant development challenges. ECMO's development and production capabilities, to a certain extent, represent a country's advanced medical device technology. ECMO plays a vital role in treating critically ill patients with infectious diseases and other causes of cardiopulmonary disease. ECMO is also widely used in emergency treatment and treatment for neonatal heart and respiratory failure, adult acute respiratory syndrome, cardiac arrest, intraoperative extracorporeal circulation support, cardiogenic or postoperative shock, and the transport of critically ill patients. my country currently has no domestically produced ECMO equipment; all clinically used are imported products, which are scarce and expensive, placing a heavy burden on healthcare and hindering public safety emergency response. The membrane oxygenator (membrane lung) is a key component in ECMO systems.

[0003] For example, the utility model disclosed in Publication No. CN201091703Y discloses a switching circuit between extracorporeal membrane oxygenation (ECMO) and extracorporeal circulation (CPB), comprising first and second venous return lines, a blood reservoir, a centrifugal pump head, a membrane lung, a microembolic filter, and an arterial blood supply line. The first venous return line, the blood reservoir, the centrifugal pump head, the membrane lung, the microembolic filter, and the aortic blood supply line are sequentially connected via pipes. A first three-way connector is provided between the first venous return line and the blood reservoir, and a second three-way connector is provided between the blood reservoir and the centrifugal pump head. A bypass connection pipe is provided between the membrane lung and the aortic blood supply line. A third three-way connector is also connected to the first three-way connector. The second venous return line is sequentially connected to the third three-way connector, the second three-way connector, and the centrifugal pump head via pipes, thereby forming a bypass from the vein to the centrifugal pump head connection pipe. The above scheme not only allows for independent ECMO and conventional CPB, but also allows for direct conversion between ECMO and conventional CPB.

[0004] However, in order to meet the needs of patients undergoing combined CRRT treatment, the above scheme and the current membrane oxygenator require the addition of a connecting tube at the front and back ends of the membrane oxygenator. The connecting tube is an additional pipeline, which increases the step of pre-filling the machine and increases the risk of bloodstream infection. At the same time, there is no automatic opening and closing pressure valve on the added connecting tube. During the insertion and removal of the CRRT pipeline, it cannot be automatically opened and closed, which affects the rate of blood return and blood extraction. For this reason, we propose an extracorporeal circulation integrated pipeline structure for extracorporeal membrane oxygenation. Summary of the Invention

[0005] The present invention aims to provide an integrated extracorporeal circulation piping structure for an extracorporeal membrane oxygenator (ECMO) to address the problem, raised in the aforementioned background art, that current membrane oxygenators require the addition of connecting tubes at both the front and rear ends of the membrane oxygenator to meet the needs of patients undergoing combined CRRT treatment. These connecting tubes are additional piping, adding a priming step and increasing the risk of bloodstream infection. Furthermore, the added connecting tubes lack an automatic opening and closing pressure valve, preventing automatic opening and closing during insertion and removal of the CRRT tubing, thereby affecting the blood return and blood extraction rates.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an integrated extracorporeal circulation piping structure for an extracorporeal membrane oxygenator, comprising a membrane oxygenator body, a first venous return port provided at one end of the membrane oxygenator body, the first venous return port being integrally formed with an end of the membrane oxygenator body, an integrally formed first venous return tube provided on the first venous return port, a second venous return port provided at the other end of the membrane oxygenator body, and an integrally formed second venous return tube provided on the second venous return port. The integrated piping structure reduces the number of steps required to connect the oxygenator, reduces the risk of blood infection in patients, saves time during connection, and reduces patient treatment costs.

[0007] Wherein, the first venous return tube and the second venous return tube are both provided with a pressure control valve body, and the pressure control valve body is used to automatically open and close the blood return or blood drainage pathway during the insertion and removal of the CRRT tube;

[0008] The pressure control valve body includes a valve seat, a stepped thread section is provided on one side of the valve seat, a multi-stage sealing structure is also provided inside the valve seat, and the valve seat is detachably connected to the CRRT pipeline joint.

[0009] Preferably, the multi-stage sealing structure includes an inner carrier plate, which is connected to the inner wall of the valve seat through a connecting rod, a piston covering film is provided on one side of the inner carrier plate, a first spring is provided in the piston covering film, one end of the first spring is connected to the piston rod, and a bottom piston pad is provided on one side of the piston rod, the bottom piston pad is fitted with the bottom of the threaded segment, and the elastic force of the first spring can automatically seal the connection between the threaded segment and the valve body.

[0010] Preferably, a top piston pad is provided at the end of the piston rod, and the top piston pad is movably provided in the threaded section. The top piston pad is used to seal the inner wall of the threaded section. Through the elastic force of the first spring, the top piston pad can automatically seal the threaded section.

[0011] Preferably, a special-shaped sealing rubber ring is further provided on the outer surface of the top piston pad, and the special-shaped sealing rubber ring is clamped with the special-shaped sealing groove. The special-shaped sealing groove is provided on the inner surface of the threaded section, which can further improve the sealing of the threaded section and prevent blood overflow.

[0012] Preferably, the special-shaped sealing rubber ring includes a parallel sealing portion, an arc-shaped clamping portion and an inclined lead-out portion. The parallel sealing portion fits with the horizontal sealing portion in the special-shaped sealing groove, which can improve the sealing tightness between the special-shaped sealing ring and the special-shaped sealing groove. The arc-shaped clamping portion corresponds to the arc-shaped fitting portion in the special-shaped sealing groove, which can position and fix the special-shaped sealing rubber ring. The inclined lead-out portion corresponds to the inclined portion in the special-shaped sealing groove, which facilitates the special-shaped sealing rubber ring to be led out of the special-shaped sealing groove.

[0013] Preferably, a trapezoidal guide groove is further provided on the inner wall of the threaded section, and the trapezoidal guide groove provides a gap space for the top piston pad, which can guide the blood and guide the blood into the passage tube.

[0014] Preferably, the CRRT pipeline joint includes a threaded connection cap, which corresponds to the threaded section. A passage tube is arranged in the threaded connection cap, and a thimble is also arranged in the passage tube, which corresponds to the top piston pad. The passage tube is connected to the CRRT branch pipe. During the connection process between the CRRT pipeline joint and the threaded section, the top piston pad can be automatically driven to move, thereby realizing automatic diversion of blood.

[0015] Preferably, a plurality of groups of automatic clamping components for assisting in fixing the passage tube are provided in the threaded section, the automatic clamping components include a groove, a second spring is provided in the groove, one end of the second spring is connected to the mounting seat, the mounting seat is movably provided in the groove, and a ball is rotatably provided in the mounting seat, which can improve the connection stability of the passage tube and prevent the CRRT pipe joint from loosening.

[0016] Preferably, the balls are connected to annular positioning grooves, and the annular positioning grooves are evenly arranged on the outer surface of the passage tube.

[0017] Preferably, limiting sliding blocks are provided on both sides of the mounting seat, one end of the limiting sliding block is slidably provided in the limiting sliding groove, and the limiting sliding grooves are symmetrically provided on both side surfaces of the groove, thereby improving the guiding performance of the mounting seat when moving.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) The present application adopts an integrated molding structure as a whole, which does not require the external connection of the first venous return tube and the second venous return tube, eliminating the operation steps of pre-filling the machine by medical staff, reducing the patient's blood infection rate, shortening the machine time, and reducing the patient's treatment costs.

[0020] (2) During the insertion and removal of the CRRT pipeline, the present application can automatically open the valve seat and perform multi-stage sealing, thereby achieving rapid and automatic opening and closing of the valve seat, while preventing blood overflow and achieving good sealing performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0022] Figure 2 It is a schematic diagram of the three-dimensional structure of the pressure control valve body of the present invention;

[0023] Figure 3 This is a schematic diagram of a half-section structure of the pressure control valve body of the present invention;

[0024] Figure 4 Schematic diagram of the three-dimensional structure of the multi-stage sealing structure of the present invention;

[0025] Figure 5 Schematic diagram of the structure of the top piston pad in the present invention;

[0026] Figure 6 for Figure 3 A schematic diagram of the partially enlarged structure of the middle part A;

[0027] Figure 7 Schematic diagram of the half-section structure of the CRRT pipe joint in the present invention;

[0028] Figure 8 for Figure 7 A schematic diagram of the partially enlarged structure of part B in the middle;

[0029] Figure 9 Schematic diagram of the cross section of the pressure control valve body and the CRRT pipeline joint in the present invention;

[0030] Figure 10 for Figure 9 A schematic diagram of the partially enlarged structure of the middle C part;

[0031] Figure: 1, pressure control valve body; 2, first venous return tube; 3, first venous return port; 4, membrane oxygenator body; 5, second venous return port; 6, second venous return tube; 11, connecting tube; 12, valve seat; 13, multi-stage sealing structure; 14, threaded section; 15, trapezoidal guide groove; 101, threaded connection cap; 102, ejector pin; 103, access tube; 104, CRRT branch tube; 105, connecting rod; 106, annular positioning groove; 131, piston rod; 132, inner carrier plate; 133, ejector pin The piston pad is as follows: 134, special-shaped sealing rubber ring; 135, bottom piston pad; 136, L-shaped sealing rubber ring; 137, piston coating film; 138, first spring; 139, connecting rod; 141, ball bearing; 142, mounting seat; 143, limiting slider; 144, limiting slide groove; 145, groove; 146, second spring; 1341, parallel sealing part; 1342, arc-shaped clamping part; 1343, inclined lead-out part; 1401, horizontal sealing part; 1402, arc-shaped fitting part; 1043, inclined part. DETAILED DESCRIPTION

[0032] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0033] See also Figure 1 The present invention provides a technical solution: an integrated extracorporeal circulation piping structure for an extracorporeal membrane oxygenator, comprising a membrane oxygenator body 4, a first venous return port 3 provided at one end of the membrane oxygenator body 4, the first venous return port 3 being integrally formed with an end of the membrane oxygenator body 4, a first venous return tube 2 being integrally formed on the first venous return port 3, a second venous return port 5 being integrally formed therewith at the other end of the membrane oxygenator body 4, and a second venous return tube 6 being integrally formed therewith on the second venous return port 5. Specifically, the first venous return tube 2 and the second venous return tube 6 are both integrally formed of medical-grade sterile plastic. The overall integrated piping structure reduces the number of steps required for operation, reduces the risk of blood infection in patients, saves operation time, and reduces patient treatment costs.

[0034] See also Figure 2-Figure 4, a pressure control valve body 1 is provided on both the first venous return tube 2 and the second venous return tube 6, and the pressure control valve body 1 is used to automatically open and close the blood return or blood withdrawal path during the insertion and removal of the CRRT pipeline; the pressure control valve body 1 includes a valve seat 12, a connecting tube 11 is provided on one side of the valve seat 12, and the connecting tube 11 is integrally connected with the first venous return tube 2 and the second venous return tube 6, a stepped threaded section 14 is provided on one side of the valve seat 12, and a multi-stage sealing structure 13 is also provided in the valve seat 12, and the valve seat 12 and the CRRT pipeline connector are detachably connected; the multi-stage sealing structure 13 includes an inner carrier plate 132, and the inner carrier plate 132 is connected to the inner wall of the valve seat 12 through a connecting rod 139, a piston coating film 137 is provided on one side of the inner carrier plate 132, and a first spring 138 is provided in the piston coating film 137, and one end of the first spring 138 is connected to the piston rod 131. Specifically, the piston coating film 137 can expand and contract with the first spring 138 to ensure blood circulation , to prevent the first spring 138 from blocking blood circulation, a bottom piston pad 135 is provided on one side of the piston rod 131, and the bottom piston pad 135 is in contact with the bottom of the threaded section 14. Through the elastic force of the first spring 138, the connection between the threaded section 14 and the valve seat 12 can be automatically sealed; a top piston pad 133 is provided at the end of the piston rod 131, and the top piston pad 133 is movably arranged in the threaded section 14. The top piston pad 133 is used to seal the inner wall of the threaded section 14. Through the elastic force of the second spring 146, the top piston pad 133 can automatically seal the threaded section 14. When the CRRT pipeline connector is inserted into the threaded section 14, it can simultaneously drive the top piston pad 133 and the bottom piston pad 135 to move, and at the same time the piston rod 131 compresses the first spring 138. When the CRRT pipeline connector is pulled out, the top piston pad 133 and the bottom piston pad 135 return to their original position and perform secondary sealing on the valve body.

[0035] Furthermore, an L-shaped sealing rubber ring 136 is provided on one side surface of the bottom piston pad 135. When the bottom piston pad 135 is in contact with the bottom of the threaded section 14, the L-shaped sealing rubber ring 136 is in contact with the inner wall of the threaded section 14 and the inner wall of the valve body at the same time, thereby improving the sealing performance.

[0036] See also Figure 5The outer surface of the top piston pad 133 is also provided with a special-shaped sealing rubber ring 134, which is clamped with the special-shaped sealing groove. The special-shaped sealing groove is provided on the inner surface of the threaded segment 14, which can further improve the sealing of the threaded segment 14 and prevent blood overflow; the special-shaped sealing rubber ring 134 includes a parallel sealing portion 1341, an arc-shaped clamping portion 1342 and an inclined lead-out portion 1343. The parallel sealing portion 1341 is fitted with the horizontal sealing portion 1401 in the special-shaped sealing groove, which can improve the sealing tightness between the special-shaped sealing rubber ring 134 and the special-shaped sealing groove. The arc-shaped clamping portion 1342 corresponds to the arc-shaped fitting portion 1402 in the special-shaped sealing groove, which can position and fix the special-shaped sealing rubber ring 134. The inclined lead-out portion 1343 corresponds to the inclined portion 1043 in the special-shaped sealing groove, which is convenient for the special-shaped sealing rubber ring 134 to be guided out of the special-shaped sealing groove.

[0037] Furthermore, a trapezoidal guide groove 15 is provided on the inner wall of the threaded section 14 . The trapezoidal guide groove 15 provides a gap space for the top piston pad 133 , thereby guiding the blood and directing the blood into the passage tube 103 .

[0038] See also Figure 7 as well as Figure 8 The CRRT pipeline connector includes a threaded connection cap 101, which corresponds to the threaded section 14. A passage tube 103 is arranged in the threaded connection cap 101, and a thimble 102 is also arranged in the passage tube 103. Specifically, the thimble 102 is connected to the passage tube 103 through a connecting rod 105. The thimble 102 corresponds to the top piston pad 133. The passage tube 103 is connected to the CRRT branch tube 104. During the connection process between the CRRT pipeline connector and the threaded section 14, the top piston pad 133 can be automatically driven to move, thereby realizing automatic diversion of blood.

[0039] See also Figure 3 as well as Figure 6, the threaded section 14 is also provided with multiple groups of automatic clamping components for auxiliary fixation of the passage tube 103, the automatic clamping components include a groove 145, a second spring 146 is further provided in the groove 145, one end of the second spring 146 is connected to the mounting seat 142, the mounting seat 142 is movably provided in the groove 145, a ball 141 is rotatably provided in the mounting seat 142, the ball 141 is connected to the annular positioning groove 106, the annular positioning groove 106 is evenly provided on the outer surface of the passage tube 103, when the passage tube 103 is inserted into the threaded section 14, the passage tube 103 is squeezed The ball 141 is pressed, and the ball 141 rotates in the mounting seat 142, and at the same time, the mounting seat 142 is squeezed to move in the groove 145. The mounting seat 142 compresses the second spring 146. When the threaded connection cap 101 is locked with the threaded section 14, the second spring 146 drives the mounting seat 142 to reset and move through the elastic force. The reset movement of the mounting seat 142 drives the ball 141 to reset and move, and the ball 141 is stuck in the corresponding annular positioning groove 106, which can improve the connection stability of the access tube 103 and prevent the CRRT pipeline joint from loosening.

[0040] Furthermore, limiting sliders 143 are set on both sides of the mounting seat 142, and one end of the limiting slider 143 is slidably set in the limiting slide groove 144. The limiting slide groove 144 is symmetrically set on the two side surfaces of the groove 145. When the mounting seat 142 moves, it drives the limiting slider 143 to move in the limiting slide groove 144, thereby improving the guiding performance of the mounting seat 142 when moving.

[0041] See also Figure 10When CRRT treatment is needed, the ejector pin 102 in the CRRT pipe joint is inserted into the threaded section 14. When the ejector pin 102 contacts the top piston pad 133, the ejector pin 102 drives the top piston pad 133 to move in the threaded section 14. The top piston pad 133 drives the movable rod to move, and the piston rod 131 drives the bottom piston pad 135 to move. The piston rod 131 compresses the first spring 138. When the threaded connection cap 101 is fitted with the threaded section 14, the threaded connection cap 101 is rotated. The threaded connection cap 101 drives the passage tube 103 to rotate and is inserted into the threaded section 14. When the threaded connection cap 101 rotates and moves, the ejector pin 102 drives the top piston pad 133 to move and moves the top piston pad 133 into the trapezoidal guide groove 15. At this time, The threaded connection cap 101 is locked with the threaded end, and the blood in the first venous return tube 2 is drained or returned to the valve seat 12 through the connecting tube 11, and then the blood is guided by the trapezoidal guide groove 15 to the access tube 103. The access tube 103 transports the blood to the CRRT branch tube 104, and CRRT treatment is performed. After the treatment is completed, the threaded connection cap 101 is separated from the threaded segment 14, and the first spring 138 drives the piston rod 131 to quickly reset and move under the action of the elastic force. The piston rod 131 also drives the bottom piston pad 135 and the top piston pad 133 to reset and move synchronously. The top piston pad 133 seals the threaded segment 14, and the bottom piston pad 135 seals the bottom of the threaded segment 14 to prevent blood overflow, thereby realizing the automatic opening and closing function.

[0042] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. An extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator, comprising a membrane oxygenator body (4), characterized in that: A first venous return end (3) is provided at one end of the membrane oxygenator body (4), the first venous return end (3) and the end of the membrane oxygenator body (4) are integrally formed, an integrally formed first venous return tube (2) is provided on the first venous return end (3), a second venous return end (5) is provided at the other end of the membrane oxygenator body (4), and an integrally formed second venous return tube (6) is provided on the second venous return end (5); Wherein, a pressure control valve body (1) is provided on each of the first venous return tube (2) and the second venous return tube (6), and the pressure control valve body (1) is used to automatically open and close the blood return or blood drainage pathway during the insertion and removal of the CRRT pipeline; The pressure control valve body (1) comprises a valve seat (12), a stepped threaded section (14) is provided on one side of the valve seat (12), a multi-stage sealing structure (13) is further provided in the valve seat (12), and the valve seat (12) is detachably connected to the CRRT pipeline connector.

2. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 1, characterized in that: The multi-stage sealing structure (13) includes an inner carrier plate (132), the inner carrier plate (132) is connected to the inner wall of the valve seat (12) through a connecting rod (139), a piston coating film (137) is provided on one side of the inner carrier plate (132), a first spring (138) is provided in the piston coating film (137), one end of the first spring (138) is connected to the piston rod (131), a bottom piston pad (135) is provided on one side of the piston rod (131), and the bottom piston pad (135) is in contact with the bottom of the threaded section (14).

3. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 2, characterized in that: A top piston pad (133) is provided at the end of the piston rod (131), and the top piston pad (133) is movably provided in the threaded section (14). The top piston pad (133) is used to seal the inner wall of the threaded section (14).

4. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 3, characterized in that: A special-shaped sealing rubber ring (134) is further provided on the outer surface of the top piston pad (133), and the special-shaped sealing rubber ring (134) is clamped with a special-shaped sealing groove, and the special-shaped sealing groove is provided on the inner surface of the threaded section (14).

5. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 4, characterized in that: The special-shaped sealing rubber ring (134) includes a parallel sealing portion (1341), an arc-shaped clamping portion (1342) and an inclined surface leading portion (1343), wherein the parallel sealing portion (1341) is fitted with the horizontal sealing portion (1401) in the special-shaped sealing groove, the arc-shaped clamping portion (1342) corresponds to the arc-shaped fitting portion (1402) in the special-shaped sealing groove, and the inclined surface leading portion (1343) corresponds to the inclined portion (1043) in the special-shaped sealing groove.

6. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 1 or 4, characterized in that: A trapezoidal guide groove (15) is also provided on the inner wall of the threaded section (14), and the trapezoidal guide groove (15) provides a clearance space for the top piston pad (133).

7. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 1, characterized in that: The CRRT pipe joint comprises a threaded connection cap (101), the threaded connection cap (101) corresponds to the threaded section (14), a passage tube (103) is arranged in the threaded connection cap (101), a thimble (102) is further arranged in the passage tube (103), the thimble (102) corresponds to the top piston pad (133), and the passage tube (103) is connected to the CRRT branch pipe (104).

8. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 7, characterized in that: A plurality of automatic clamping assemblies for assisting in fixing the passage tube (103) are further provided in the threaded section (14), wherein the automatic clamping assemblies include a groove (145), a second spring (146) is further provided in the groove (145), one end of the second spring (146) is connected to the mounting seat (142), the mounting seat (142) is movably provided in the groove (145), and a ball (141) is rotatably provided in the mounting seat (142).

9. The extracorporeal circulation integrated piping structure of an extracorporeal membrane oxygenator according to claim 8, characterized in that: The balls (141) are connected to the annular positioning grooves (106), and the annular positioning grooves (106) are evenly arranged on the outer surface of the passage tube (103).

10. The extracorporeal circulation integrated pipeline structure of an extracorporeal membrane oxygenator according to claim 8, characterized in that: Limiting slide blocks (143) are provided on both sides of the mounting seat (142), one end of the limiting slide block (143) is slidably provided in a limiting slide groove (144), and the limiting slide groove (144) is symmetrically provided on both side surfaces of the groove (145).

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