Application of phloretin in preparation of bromhidrosis inhibitor and composition for inhibiting bromhidrosis

Abstract

The invention relates to the technical field of medicines, and provides application of phloretin in preparation of an bromhidrosis inhibitor and a composition for inhibiting bromhidrosis. Researches find that the phloretin can reduce the stability of MRP8 protein, reduce the protein level of the MRP8 protein and achieve the purpose of long-acting inhibition of bromhidrosis, and the phloretin has a wide application prospect when being used in preparation of the bromhidrosis inhibitor. The composition for inhibiting bromhidrosis provided by the invention is transparent and stable, has a lasting effect of inhibiting bromhidrosis, can be prepared into spray type, roll-on type and gel type preparations by adjusting the dosage of the viscosity modifier, and has a wide market prospect; meanwhile, the composition provided by the invention does not contain aluminum and is good in safety.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, in particular to application of phloretin in preparing a composition for inhibiting underarm odor and a composition for inhibiting underarm odor. Background Art

[0002] Underarm odor, which can cause unpleasant odors and stain clothing, is a painful and troublesome problem. Some people experience excessive fear, aversion, or psychological hypersensitivity to unpleasant odors, even developing olfactory phobia. Underarm odor can severely impact work, personal life, and social interactions.

[0003] Currently, most anti-breast odor medications on the market are antiperspirants, which work by inhibiting perspiration from the apocrine sweat glands in the armpits, thereby suppressing the production of underarm odor. The main antiperspirants used are aluminum chloride or aluminum zirconium chloride. However, these methods have the following drawbacks: 1) their mechanism is unclear; 2) aluminum may affect the nervous system, raising safety concerns; 3) long-term use of antiperspirants may be associated with breast cancer in some women; and 4) side effects such as skin darkening and allergies can occur. Therefore, the development of aluminum-free formulations is currently the primary focus of research and development for these agents.

[0004] Research has shown that the production of body odor is genetically determined. The secretion of body odor precursors is linked to the human ABCC11 gene. In polarized cells within the apocrine sweat glands, the ABCC11 gene expresses the odor precursor transporter protein MRP8, which is responsible for transporting odor precursors into the sweat vacuole. Individuals without body odor have a G538A mutation in the ABCC11 gene. This mutation inhibits N-glycosylation of MRP8 at sites N838 and N844, reducing its stability. This mutation renders the ABCC11 gene dysfunctional, preventing it from transporting odor precursors out of the body through the sweat glands, thus preventing the production of body odor. Therefore, theoretically, inhibiting MRP8 activity could reduce the transport of odor precursors.

[0005] Phloretin is a natural dihydrochalcone compound found widely in fruits such as apples and pears, as well as in apple bark. It possesses multiple biological activities, including antioxidant, anti-inflammatory, and antibacterial properties. Studies have shown that phloretin can inhibit tyrosinase activity, regulate cell metabolism, and has low skin irritation. It has shown promising potential for use in whitening and anti-inflammatory skincare products. However, there are currently no studies on the use of phloretin as a suppressant for underarm odor. Summary of the Invention

[0006] In light of this, the present invention provides the use of phloretin in preparing a composition for suppressing underarm odor, as well as a composition for suppressing underarm odor. The present invention has discovered that phloretin can reduce the level of the odor precursor transporter protein MRP8. When phloretin is used in an underarm odor suppressant, a long-lasting suppressant can be obtained.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] Application of phloretin in the preparation of axillary odor inhibitor.

[0009] The present invention also provides a composition for inhibiting underarm odor, comprising the following components in mass fractions: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 1-6% of a surfactant, 0.2-2% of an antibacterial agent, 0.1-50% of a cosurfactant, 1-8% of oil, 0-3% of a viscosity regulator, and the balance being water; the phloretin is used in the form of pure phloretin or an extract containing phloretin.

[0010] Preferably, the surfactant includes one or more of a nonionic surfactant and an amphoteric surfactant; the nonionic surfactant includes one or more of fatty alcohol polyoxyethylene ether, polyoxyethylene ether fatty acid ester, polyethylene glycol fatty acid glyceride, polyethylene glycol dehydrated sorbitan monofatty acid ester, sugar ester and polyglycerol fatty acid ester; the amphoteric surfactant includes lecithin.

[0011] Preferably, the number of carbon atoms of the fatty alcohol unit in the fatty alcohol polyoxyethylene ether is 8 to 18, and the average degree of polymerization of the polyoxyethylene ether unit is 7 to 20; the average degree of polymerization of the polyoxyethylene ether unit in the polyoxyethylene ether fatty acid ester is 12 to 25, and the number of carbon atoms of the fatty acid unit is 8 to 18; the average degree of polymerization of the polyethylene glycol unit in the polyethylene glycol fatty acid glyceride is 6 to 23, and the number of carbon atoms of the fatty acid unit is 8 to 18; the number of carbon atoms of the fatty acid unit in the polyethylene glycol dehydrated sorbitan monofatty acid ester is 8 to 18; and the sugar ester includes one or more of fatty acid monosaccharide ester and fatty acid polysaccharide ester.

[0012] Preferably, the fatty alcohol polyoxyethylene ether includes fatty alcohol polyoxyethylene ether-9; the polyoxyethylene ether fatty acid ester includes polyoxyethylene ether-40 hydrogenated castor oil; the polyethylene glycol fatty acid glyceride includes one or both of polyethylene glycol (20) lauric acid glyceride and polyethylene glycol (20) oleic acid glyceride; the polyethylene glycol dehydrated sorbitan monofatty acid ester includes one or both of TW-20 and TW-80; the sugar ester includes sucrose laurate; the polyglycerol fatty acid ester includes one or more of poly-10 glyceryl laurate and poly-7 glyceryl laurate.

[0013] Preferably, the antibacterial agent comprises one or more of farnesol, phenoxyethanol, ethylhexylglycerin and laurate;

[0014] The cosurfactant comprises one or more of C2-C6 short-chain alcohols, polyols, organic acids, polyglycol compounds, formamide, butyl lactate and amino acids;

[0015] The oils and fats include one or more of chain esters, monoglycerides and lactates;

[0016] The viscosity modifier includes one or more of cellulose derivatives, natural gums and synthetic thickeners.

[0017] Preferably, the C2-C6 short-chain alcohol includes one or more of ethanol, propanol, butanol and 1-hexanol; the polyol includes one or more of propylene glycol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, glycerol and 1,3-butanediol; the organic acid includes one or more of propionic acid, butyric acid and oleic acid; the polyethylene glycol compound includes one or more of diethylene glycol ethyl ether and polyethylene glycol 400; and the amino acid includes lysine.

[0018] Preferably, the chain esters include one or more of isopropyl myristate, isopropyl palmitate, dicaprylyl carbonate, caprylic / capric triglyceride, triethyl glycerol, tributyrin, tricaprylin, propylene glycol caprylate, propylene glycol dioctyldecyl ester, diisopropyl adipate, dibutyl adipate, isopropyl palmitate, ethyl oleate, n-butyl oleate, acetylated monoglyceride, ethyl acetate, ethyl butyrate, ethyl caprylate and injection-grade soybean oil; the monoglyceride includes one or more of monolauric acid monoglyceride, monooleyl glyceride, monoisostearate, monomyristyl glyceride and monocaprylic acid glyceride; the lactic acid ester includes one or more of lauryl lactate, myristyl lactate, palmityl lactate and isostearyl lactate.

[0019] Preferably, the cellulose derivative includes one or more of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose and hydroxymethyl cellulose; the natural gum includes one or more of xanthan gum and guar gum; and the synthetic thickener includes one or more of carbomer, polyvinyl pyrrolidone and sodium polyacrylate.

[0020] Preferably, the composition for inhibiting underarm odor further comprises a pH adjuster, and the amount of the pH adjuster used is based on adjusting the pH value of the composition to 4-5.

[0021] Preferably, the composition for inhibiting underarm odor includes the following components in mass fraction: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 0-0.8% of farnesol, 1%-6% of lauryl lactate, 0-4% of poly-10 glyceryl laurate, 0-4% of polyoxyethylene fatty alcohol ether-90, 0-4% of sucrose laurate, 0-4% of polyoxyethylene ether-40 hydrogenated castor oil, 0.1-0.8% of phenoxyethanol, 0-0.5% of monolaurin, 0-3% of carbomer, 0-2% of triethanolamine, 10-50% of ethanol, and the balance is water.

[0022] The present invention provides the use of phloretin in the preparation of axillary odor suppressants. The present invention has found that phloretin can reduce the stability of MRP8 protein, thereby reducing its protein level, achieving the purpose of long-term suppression of axillary odor. The use of phloretin in the preparation of axillary odor suppressants has broad application prospects.

[0023] The present invention also provides a composition for inhibiting underarm odor, comprising the following components by mass: 0.1-1% phloretin, 0.1-1% glycyrrhetinic acid, 1-6% surfactant, 0.2-2% antibacterial agent, 0.1-50% cosurfactant, 1-8% oil, 0-3% viscosity modifier, and the balance water; the phloretin is used in the form of pure phloretin or a phloretin-containing extract. The composition for inhibiting underarm odor provided by the present invention is transparent and stable, has a long-lasting effect, and can be prepared into spray-, roll-on, and gel-type preparations by adjusting the amount of viscosity modifier, thus having broad market prospects. Furthermore, the composition provided by the present invention does not contain aluminum and has good safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is the test result of Example 1 in which phloretin reduces the level of MRP8 protein in cells. DETAILED DESCRIPTION

[0025] The present invention provides application of phloretin in preparing an underarm odor inhibitor.

[0026] In the present invention, the phloretin is preferably used together with glycyrrhetinic acid, and the phloretin can be used in the form of pure phloretin or an extract containing phloretin, which will be described in detail later.

[0027] The present invention also provides a composition for inhibiting underarm odor, comprising the following components in mass fractions: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 1-6% of a surfactant, 0.2-2% of an antibacterial agent, 0.1-50% of a cosurfactant, 1-8% of oil, 0-3% of a viscosity regulator, and the balance being water; the phloretin is used in the form of pure phloretin or an extract containing phloretin.

[0028] Unless otherwise specified, all raw materials used in this application are commercially available cosmetic grade raw materials.

[0029] The composition for suppressing underarm odor provided by the present invention comprises 0.1-1%, preferably 0.3-0.8%, and specifically 0.7% of phloretin by mass. The phloretin is used in the form of pure phloretin or an extract containing phloretin. The present invention has no special requirements for the extraction method of the phloretin-containing extract, and a method well known to those skilled in the art can be used. The phloretin-containing extract is specifically an extract containing phloretin as the main component. When the phloretin-containing extract is used, the mass of the phloretin-containing extract is measured by the mass of the phloretin contained therein. The phloretin can reduce the stability of the MRP8 protein and reduce its protein level, thereby inhibiting the transport of odor precursors and achieving the purpose of suppressing underarm odor.

[0030] The composition for inhibiting underarm odor provided by the present invention comprises 0.1-1%, preferably 0.4-0.6%, and specifically 0.5%, of glycyrrhetinic acid by mass. The glycyrrhetinic acid has antibacterial activity, inhibiting the growth of bacteria associated with underarm odor. It also inhibits MPR8, inhibiting the transport of odorous substances. Furthermore, glycyrrhetinic acid can inhibit P-gp and MRP1, and phloretin is a P-gp substrate. Therefore, glycyrrhetinic acid inhibits the pumping of phloretin by P-gp, thereby enhancing its absorption. Furthermore, glycyrrhetinic acid is also an immunomodulator, thereby improving its usability on sensitive skin.

[0031] In terms of mass fraction, the composition for inhibiting underarm odor provided by the present invention includes 1-6% of a surfactant, preferably 4-5%, and specifically 4.8%; the surfactant preferably includes one or more of a nonionic surfactant and amphoteric surfactant; the nonionic surfactant preferably includes one or more of fatty alcohol polyoxyethylene ether, polyoxyethylene ether fatty acid ester, polyethylene glycol fatty acid glyceride, polyethylene glycol dehydrated sorbitan monofatty acid ester, sugar ester and polyglycerol fatty acid ester; the number of carbon atoms of the fatty alcohol unit in the fatty alcohol polyoxyethylene ether is preferably 8-18, and the average polymerization degree of the polyoxyethylene ether unit is preferably 7-20. Specifically, the fatty alcohol polyoxyethylene ether preferably includes fatty alcohol polyoxyethylene ether-9 (AEO9); the average polymerization degree of the polyoxyethylene ether unit in the polyoxyethylene ether fatty acid ester is preferably 12-25, and the number of carbon atoms of the fatty acid unit is preferably 8-18. Specifically, the polyoxyethylene ether fatty acid ester preferably includes polyoxyethylene ether-9 (AEO9); the average polymerization degree of the polyoxyethylene ether unit in the polyoxyethylene ether fatty acid ester is preferably 12-25, and the number of carbon atoms of the fatty acid unit is preferably 8-18. Oxyethylene ether-40 hydrogenated castor oil (CO40); the average degree of polymerization of the polyethylene glycol unit in the polyethylene glycol fatty acid glyceride is preferably 6 to 23, and the number of carbon atoms of the fatty acid unit is preferably 8 to 18; specifically, the polyethylene glycol fatty acid glyceride preferably includes one or both of polyethylene glycol (20) lauric acid glyceride and polyethylene glycol (20) oleic acid glyceride; the number of carbon atoms of the fatty acid unit in the polyethylene glycol dehydrated sorbitan monofatty acid ester is preferably 8 to 18, specifically, the polyethylene glycol dehydrated sorbitan monofatty acid ester preferably includes one or both of TW-20 and TW-80; the sugar ester is preferably fatty acid glycolipid, specifically including one or more of fatty acid monosaccharide and fatty acid polysaccharide, the number of carbon atoms of the fatty acid unit in the fatty acid glycolipid is preferably 12 to 18, specifically it can be sucrose laurate; the polyglycerol fatty acid ester preferably includes one or both of poly-10 glyceryl laurate and poly-7 glyceryl laurate.

[0032] In the present invention, the amphoteric surfactant preferably includes lecithin.

[0033] In a specific embodiment of the present invention, the surfactant preferably includes at least one of poly 10 glyceryl laurate, AEO-9, sucrose laurate and CO40.

[0034] Calculated by mass fraction, the composition for inhibiting underarm odor provided by the present invention includes 0.2-2% of an antibacterial agent, preferably 0.5-1.5%, specifically 0.9%, 0.98% or 1%; the antibacterial agent preferably includes one or more of farnesol, phenoxyethanol, ethylhexylglycerin and lauric acid ester; the lauric acid ester preferably includes one or more of monolaurin and poly-10 glyceryl laurate; the monolaurin and poly-10 glyceryl laurate have both emulsifying effect and antibacterial activity.

[0035] Calculated by mass fraction, the composition for inhibiting underarm odor provided by the present invention includes 0.1 to 50% of a co-surfactant, preferably 5 to 45%; the co-surfactant preferably includes one or more of C2 to C6 short-chain alcohols, polyols, organic acids, polyglycol compounds, formamide, butyl lactate and amino acids; the C2 to C6 short-chain alcohols preferably include one or more of ethanol, propanol, butanol and 1-hexanol; the polyols preferably include one or more of propylene glycol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, glycerol and 1,3-butanediol; the organic acid preferably includes one or more of propionic acid, butyric acid and oleic acid; the polyethylene glycol compound preferably includes one or more of diethylene glycol ethyl ether (carbitol) and polyethylene glycol 400 (PEG400); the amino acid preferably includes lysine.

[0036] In terms of mass fraction, the composition for inhibiting underarm odor provided by the present invention comprises 1 to 8% of oil, preferably 1 to 7%, and more preferably 2 to 6% of oil; the oil preferably comprises one or more of chain esters, monoglycerides and lactic acid esters; the chain esters preferably comprise one or more of isopropyl myristate, isopropyl palmitate, dicaprylyl carbonate, caprylic / capric triglyceride, triethyl glycerol, tributyrin, tricaprylin, propylene glycol caprylate, propylene glycol dioctyldecyl adipate, diisopropyl adipate, dibutyl adipate, isopropyl palmitate, ethyl oleate, n-butyl oleate, acetylated monoglyceride, ethyl acetate, ethyl butyrate, ethyl caprylate and injection-grade soybean oil; the monoglyceride preferably comprises one or more of monolauric acid monoglyceride, monooleyl glyceride, monoisostearate, monomyristyl glyceride and monocaprylic acid glyceride; the lactic acid ester preferably comprises one or more of lauryl lactate, myristyl lactate, palmityl lactate and isostearyl lactate.

[0037] The underarm odor-suppressing composition provided by the present invention includes, by mass, 0-3%, preferably 0.75-1.5%, of a viscosity modifier. The viscosity modifier preferably includes one or more of a cellulose derivative, a natural gum, and a synthetic thickener. The cellulose derivative preferably includes one or more of carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose (MC), and hydroxymethyl cellulose. The natural gum preferably includes one or more of xanthan gum and guar gum. The synthetic thickener preferably includes one or more of carbomer, polyvinyl pyrrolidone, and sodium polyacrylate. By adjusting the viscosity of the composition by controlling the amount of viscosity modifier, spray-, roll-on, and gel-type preparations can be prepared.

[0038] Calculated by mass, the composition for suppressing underarm odor provided by the present invention includes the balance of water.

[0039] In the present invention, the composition for inhibiting underarm odor preferably further includes a pH regulator, and the amount of the pH regulator is based on adjusting the pH value of the composition to 4-5; in a specific embodiment of the present invention, when carbomer is used as the viscosity regulator, the pH regulator is preferably added to adjust the pH value of the composition; when the amount of the viscosity regulator is 0, or when other neutral viscosity regulators are used, the pH regulator may not be added; the pH regulator is preferably triethanolamine.

[0040] In the present invention, the composition for inhibiting underarm odor preferably comprises the following components by mass fraction: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 0.8-0.8% of farnesol, 1%-6% of lauryl lactate, 0-4% of poly-10 glyceryl laurate, 0-4% of polyoxyethylene fatty alcohol ether-90, 0-4% of sucrose laurate, 0-4% of polyoxyethylene ether-40 hydrogenated castor oil, 0.1-0.8% of phenoxyethanol, 0-0.5% of monolaurin, and 0.5% of carbomer. The invention relates to a novel composition comprising the following: a first-class chemical composition comprising: a first-class chemical composition comprising: an alcohol-based ...

[0041] Specifically, the mass fraction of phloretin is preferably 0.3-0.8%, specifically 0.7%, the mass fraction of glycyrrhetinic acid is preferably 0.2-0.6%, specifically 0.5%, the mass fraction of farnesol is preferably 0-0.5%, specifically 0.38%, the mass fraction of lauryl lactate is preferably 4-5%, specifically 4.8%, the mass fraction of poly-10 glycerol laurate is preferably 0.1-0.2%, specifically 0.12%, the mass fraction of fatty alcohol polyoxyethylene ether-9 is preferably 0-2.5%, specifically 2.4%, the mass fraction of sucrose laurate is preferably 0. The mass fraction of PEG-40 hydrogenated castor oil is preferably 0-2%, specifically 1.6%, the mass fraction of phenoxyethanol is preferably 0.5-0.7%, specifically 0.6%, the mass fraction of monolaurin is preferably 0-0.15%, specifically 0.12%, the mass fraction of carbomer is preferably 0-1.5%, specifically 0.75% or 1.5%, the mass fraction of triethanolamine is preferably 1-2%, and the mass fraction of ethanol is preferably 25-45%, specifically 30% or 44%.

[0042] In the present invention, when the amount of the viscosity modifier is 0, the composition is an emulsion and can be put into a spray bottle to prepare a spray preparation; when the amount of the viscosity modifier is small, the composition has a certain viscosity and can be put into a roll-on bottle to prepare a roll-on preparation; when the amount of the viscosity modifier is large, the viscosity of the composition is large and can be put into an emulsion dropper bottle to prepare a gel preparation.

[0043] The present invention has no special requirements on the preparation method of the composition for inhibiting underarm odor.

[0044] Specifically, when the amount of viscosity regulator in the composition is 0, the preparation method preferably includes: mixing the components except water to obtain a mixture, then adding water to the mixture under stirring conditions, and continuing stirring for 20 to 40 minutes after the addition of water is completed to obtain the composition for inhibiting underarm odor.

[0045] When the amount of the viscosity regulator in the composition is not zero and the pH value needs to be adjusted, the preparation method preferably includes: dividing water into three parts, dissolving the viscosity regulator in the first part of the water to obtain a viscosity regulator solution, and dissolving the pH regulator in the second part to obtain a pH regulator solution; mixing the components other than the viscosity regulator and the pH regulator with the third part of the water, and then adding the viscosity regulator solution and the pH regulator solution in sequence under stirring to obtain the composition for inhibiting underarm odor.

[0046] When the amount of the viscosity modifier in the composition is not zero and the pH adjustment is not required, the preparation method preferably comprises: dividing water into two parts, dissolving the viscosity modifier in the first part of water to obtain a viscosity modifier solution, mixing the second part of water with other components other than the viscosity modifier, and then sequentially adding the viscosity modifier solution under stirring to obtain the composition for inhibiting underarm odor.

[0047] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0048] The phloretin used in the following examples is all pure phloretin.

[0049] Example 1 Phloretin reduces MRP8 protein levels in cells

[0050] The ABCC11 gene was first cloned using the method described in (Bera, Lee et al., Molecular Medicine, 2001, 509-516). RACE PCR was performed using primers 5'-CCTAGTACT GAT CAC CTGCGCATC GCT-3' (SEQ ID NO. 1) and 5'-AGC GAT GCG CAG GTGATCACTAGG-3' (SEQ ID NO. 2). The 4.1 kb PCR product was cloned into the pcDNA3.1 vector to generate the plasmid pcDNA3.1\ABCC11. This plasmid was then transfected into MDCKII cells and selected with G418 to generate a stable MDCKII-ABCC11 cell line overexpressing MRP8. The MRP8-expressing MDCKII cells were incubated for 24 hours in high-glucose (22.5 mM) medium and in high-glucose (22.5 mM) medium containing 100 μM phloretin (no toxicity to cells below this concentration), and cell lysates were then prepared. The proteins were then treated with peptide N-glycosidase F (PNGase F) to convert them to non-glycosylated forms. Finally, protein levels were determined by immunoblotting.

[0051] The test results are as follows Figure 1 As shown, according to Figure 1 As can be seen from the results, the MRP8 protein level was significantly decreased in the high-glucose medium containing phloretin.

[0052] Example 2

[0053] A composition for inhibiting underarm odor was prepared according to the formula in Table 1. The specific method is as follows: mix all components except water, add water while stirring, and continue stirring for 30 minutes after adding water to obtain a transparent emulsion. The emulsion is placed in a spray bottle and can be used as a spray-type preparation.

[0054] Table 1: Formula of the composition for inhibiting underarm odor in Examples 2 to 4

[0055]

[0056] Example 3

[0057] A composition for inhibiting underarm odor was prepared according to the formula in Table 1. The specific method is as follows: mix all components except water, add water while stirring, and continue stirring for 30 minutes after adding water to obtain a transparent emulsion. The emulsion is placed in a spray bottle and can be used as a spray-type preparation.

[0058] Example 4

[0059] A composition for suppressing underarm odor was prepared according to the formula in Table 1. The specific method is as follows: lauryl lactate, phloretin, glycyrrhetinic acid, poly-10 laurin, AEO-9, monolaurin, farnesol, phenoxyethanol, and ethanol were mixed. Water was divided into three parts: one-third of the water was added to the mixture, and one-third was used to dissolve carbomer. The carbomer solution was added to the mixture under stirring, and stirring was continued until the carbomer was completely dissolved into a transparent liquid. The final one-third of the water was used to dissolve triethanolamine, and the triethanolamine solution was added dropwise to the mixture. After the addition was complete, stirring was continued for 1 hour. The resulting composition was placed in a roll-on bottle to prepare a roll-on preparation.

[0060] Example 5

[0061] A composition for suppressing underarm odor was prepared according to the formula in Table 1. The specific method is as follows: lauryl lactate, phloretin, glycyrrhetinic acid, polydecyl laurate, AEO-9, monolaurin, farnesol, phenoxyethanol, and ethanol were mixed. Water was divided into three parts: one-third of the water was added to the mixture, and one-third was used to dissolve the carbomer. The carbomer solution was added to the mixture under stirring. Stirring was continued until the carbomer was completely dissolved into a transparent liquid. The final one-third of the water was used to dissolve triethanolamine. The triethanolamine solution was added dropwise to the mixture, and stirring was continued for 1 hour after the addition was complete. The resulting composition was placed in a lotion dropper bottle to prepare a gel-type preparation.

[0062] Test Case

[0063] Seven volunteers with underarm odor used the preparation prepared in Example 3 and sprayed the product under their armpits twice. After use, a timer was kept to record the time from the fresh and pleasant smell to the generation of a faint odor. Four volunteers maintained the suppression of underarm odor for 7 days, and three volunteers maintained the suppression of underarm odor for 4 days.

[0064] The same test was performed on the preparations prepared in Examples 2 and 4 to 5, and the results showed that all of them could achieve the effect of long-term inhibition of underarm odor.

[0065] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. Application of phloretin in the preparation of axillary odor inhibitors.

2. A composition for inhibiting underarm odor, characterized in that: The invention comprises the following components by mass fraction: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 1-6% of a surfactant, 0.2-2% of an antibacterial agent, 0.1-50% of a cosurfactant, 1-8% of oil, 0-3% of a viscosity regulator, and the balance being water; the phloretin is used in the form of pure phloretin or an extract containing phloretin.

3. The composition for inhibiting underarm odor according to claim 2, characterized in that The surfactant includes one or more of a nonionic surfactant and an amphoteric surfactant; the nonionic surfactant includes one or more of a fatty alcohol polyoxyethylene ether, polyoxyethylene ether fatty acid ester, polyethylene glycol fatty acid glyceride, polyethylene glycol dehydrated sorbitan monofatty acid ester, sugar ester and polyglycerol fatty acid ester; the amphoteric surfactant includes lecithin.

4. The composition for inhibiting underarm odor according to claim 3, characterized in that The number of carbon atoms of the fatty alcohol unit in the fatty alcohol polyoxyethylene ether is 8 to 18, and the average polymerization degree of the polyoxyethylene ether unit is 7 to 20; the average polymerization degree of the polyoxyethylene ether unit in the polyoxyethylene ether fatty acid ester is 12 to 25, and the number of carbon atoms of the fatty acid unit is 8 to 18; the average polymerization degree of the polyethylene glycol unit in the polyethylene glycol fatty acid glyceride is 6 to 23, and the number of carbon atoms of the fatty acid unit is 8 to 18; the number of carbon atoms of the fatty acid unit in the polyethylene glycol dehydrated sorbitan monofatty acid ester is 8 to 18; and the sugar ester includes one or more of fatty acid monosaccharide ester and fatty acid polysaccharide ester.

5. The composition for inhibiting underarm odor according to claim 4, characterized in that The fatty alcohol polyoxyethylene ether includes fatty alcohol polyoxyethylene ether-9; the polyoxyethylene ether fatty acid ester includes polyoxyethylene ether-40 hydrogenated castor oil; the polyethylene glycol fatty acid glyceride includes one or both of polyethylene glycol (20) lauric acid glyceride and polyethylene glycol (20) oleic acid glyceride; the polyethylene glycol dehydrated sorbitan monofatty acid ester includes one or both of TW-20 and TW-80; the sugar ester includes sucrose laurate; the polyglycerol fatty acid ester includes one or more of poly-10 glyceryl laurate and poly-7 glyceryl laurate.

6. The composition for inhibiting underarm odor according to claim 2, characterized in that The antimicrobial agent comprises one or more of farnesol, phenoxyethanol, ethylhexylglycerin and laurate; The cosurfactant comprises one or more of C2-C6 short-chain alcohols, polyols, organic acids, polyglycol compounds, formamide, butyl lactate and amino acids; The oils and fats include one or more of chain esters, monoglycerides and lactates; The viscosity modifier includes one or more of cellulose derivatives, natural gums and synthetic thickeners.

7. The composition for suppressing underarm odor according to claim 6, characterized in that The C2-C6 short-chain alcohol includes one or more of ethanol, propanol, butanol and 1-hexanol; the polyol includes one or more of propylene glycol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, glycerol and 1,3-butanediol; the organic acid includes one or more of propionic acid, butyric acid and oleic acid; the polyethylene glycol compound includes one or more of diethylene glycol ethyl ether and polyethylene glycol 400; and the amino acid includes lysine.

8. The composition for inhibiting underarm odor according to claim 6, characterized in that The chain esters include one or more of isopropyl myristate, isopropyl palmitate, dicaprylyl carbonate, caprylic / capric triglyceride, triethyl glycerol, tributyrin, tricaprylin, propylene glycol caprylate, propylene glycol dioctyldecyl ester, diisopropyl adipate, dibutyl adipate, isopropyl palmitate, ethyl oleate, n-butyl oleate, acetylated monoglyceride, ethyl acetate, ethyl butyrate, ethyl caprylate and injection-grade soybean oil; the monoglyceride includes one or more of monolauric acid monoglyceride, monooleyl glyceride, monoisostearate, monomyristyl glyceride and monocaprylic acid glyceride; the lactic acid ester includes one or more of lauryl lactate, myristyl lactate, palmityl lactate and isostearyl lactate; The cellulose derivative includes one or more of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose and hydroxymethyl cellulose; the natural gum includes one or more of xanthan gum and guar gum; and the synthetic thickener includes one or more of carbomer, polyvinyl pyrrolidone and sodium polyacrylate.

9. The composition for suppressing underarm odor according to claim 1, characterized in that The composition for inhibiting underarm odor further comprises a pH adjuster, and the amount of the pH adjuster used is based on adjusting the pH value of the composition to 4-5.

10. The composition for suppressing underarm odor according to any one of claims 2 to 9, characterized in that The invention comprises the following components by mass fraction: 0.1-1% of phloretin, 0.1-1% of glycyrrhetinic acid, 0-0.8% of farnesol, 1-6% of lauryl lactate, 0-4% of poly-10 glyceryl laurate, 0-4% of fatty alcohol polyoxyethylene ether-90, 0-4% of sucrose laurate, 0-4% of polyoxyethylene ether-40 hydrogenated castor oil, 0.1-0.8% of phenoxyethanol, 0-0.5% of monolaurin, 0-3% of carbomer, 0-2% of triethanolamine, 10-50% of ethanol, and the balance is water.

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