Programmable device and medical system

Abstract

The embodiment of the present disclosure discloses a program control device and a medical system. The program control device is in communication connection with a stimulator implanted in a target object. The program control device comprises a display interface and a processor. The display interface comprises a display unit for displaying a postoperative brain model of the target object, an operation unit for an operator to select parameters, and a program control unit for delivering stimulation instructions to the stimulator. The processor is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operator on the operation unit, so that the operator can adjust the target stimulation parameter based on the target electric field model displayed on the display unit, and send the target stimulation parameter to the stimulator in a soft output mode when the operator triggers the program control unit. The technical scheme of the embodiment of the present disclosure can improve the accuracy of the adopted stimulation parameters.

Description

Technical Field

[0001] This disclosure relates to the field of electrical stimulation technology, and more particularly to a programmable device and medical system. Background Technology

[0002] With the rapid development of neuroscience, biomedical engineering, and materials science, neuromodulation technology is increasingly widely used in clinical medicine and basic research, becoming an important means of treating nervous system diseases, restoring nerve function, and exploring neural mechanisms.

[0003] Deep brain stimulation (DBS) is an invasive neuromodulation technique. This technique involves implanting stimulating electrodes into specific neural structures in the brain using stereotactic surgery, and then implanting a neurostimulator to connect to the electrodes. This delivers modulated, weak electrical pulses, thereby altering the electrical activity and function of brain neural circuits and networks to control and improve patient symptoms.

[0004] However, currently, stimulation parameters are generally adjusted based on the doctor's experience and the patient's real-time feedback until the parameters with better effect are determined. The process of adjusting electrical stimulation parameters is time-consuming and requires multiple trials, which increases the patient's discomfort and time cost. The treatment effect may be limited due to inaccurate positioning or improper parameter selection, which will affect the stimulation experience of the target object. At present, rapid and accurate adjustment for patients has become a technical problem that urgently needs to be solved. Summary of the Invention

[0005] This disclosure provides a programmable device and medical system to improve the accuracy of the stimulation parameters used.

[0006] According to one aspect of the present invention, a programmable device is provided, which is communicatively connected to a stimulator implanted in a target body. The programmable device includes: a display interface and a processor.

[0007] The display interface includes at least a display unit that displays a postoperative brain model of the target subject, an operation unit for the subject to select execution parameters, and a programmable control unit that delivers stimulation commands to the stimulator; wherein...

[0008] The processor is configured to generate a target electric field model superimposed on a postoperative brain model displayed on a display unit based on the target stimulation parameters selected by the operating object on the operating unit, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and send the target stimulation parameters to the stimulator in a soft output mode when the operating object triggers the programmable unit.

[0009] According to another aspect of the present invention, a medical system is provided, the system comprising:

[0010] The stimulator is implanted into the target subject's body;

[0011] At least one implantable electrode, each implantable electrode being at least partially implanted into a target nucleus in the brain of a target subject, the implantable electrode being connected to a stimulator and configured to deliver electrical stimulation to the target nucleus;

[0012] The programmable device provided in any embodiment of the present invention is communicatively connected to the stimulator.

[0013] The technical solution of this disclosure embodiment includes a programmable device that can communicate with a stimulator implanted in the target body. The programmable device includes a display interface and a processor. The display interface includes at least a display unit displaying a postoperative brain model of the target body, an operation unit for the user to select parameters, and a programmable unit for delivering stimulation commands to the stimulator. The processor can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit, based on the target stimulation parameters selected by the user on the operation unit. This allows the user to adjust the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit. When the user triggers the programmable unit, the target stimulation parameters are sent to the stimulator in a soft-output mode to achieve electrical stimulation of the target body. This technical solution allows for the display of a target electric field model generated based on the target stimulation parameters, enabling the user to accurately adjust the target stimulation parameters based on the displayed model, thereby improving the accuracy of the stimulation parameters used.

[0014] It should be understood that the description in this section is not intended to identify key or important features of the embodiments of the present invention, nor is it intended to limit the scope of the invention. Other features of the invention will become readily apparent from the following description. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this disclosure, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a structural block diagram of a programmable device provided according to an embodiment of the present disclosure.

[0017] Figure 2 This is a schematic diagram of a display interface in a programmable device according to an embodiment of the present disclosure.

[0018] Figure 3This is a structural block diagram of another programmable device provided according to an embodiment of the present disclosure.

[0019] Figure 4 This is a structural block diagram of another programmable device provided according to an embodiment of the present disclosure.

[0020] Figure 5 This is a schematic diagram of the display interface of Mode 1 in an optional example of another programmable device provided according to an embodiment of the present disclosure.

[0021] Figure 6 This is a schematic diagram of the display interface of Mode 2 in an optional example of another programmable device provided according to an embodiment of the present disclosure.

[0022] Figure 7 This is a structural block diagram of a medical system provided according to an embodiment of the present disclosure. Detailed Implementation

[0023] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0024] It should be noted that the terms "first," "second," etc., in the specification, claims, and accompanying drawings of this invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that embodiments of the invention described herein can be implemented in orders other than those illustrated or described herein. The same applies to "target," "original," etc., and will not be repeated here. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0025] It is understood that before using the technical solutions disclosed in the various embodiments of this disclosure, users should be informed of the types, scope of use, and usage scenarios of the personal information involved in this disclosure in an appropriate manner in accordance with relevant laws and regulations, and user authorization should be obtained.

[0026] Before introducing the embodiments of this disclosure, the technical field and related terms of the application of programmable control equipment, the current programmable control equipment solutions, and the reasons for the problem of low accuracy of the stimulus parameters used are explained by way of example, so as to better understand why the programmable control equipment solution proposed in the embodiments of this disclosure can improve the accuracy of the stimulus parameters used.

[0027] Implantable medical systems can include implantable neurostimulation systems, implantable cardiac stimulation systems (also known as pacemakers), implantable drug delivery systems (IDDS), and lead transfer systems. Implantable neurostimulation systems can be, for example, deep brain stimulation (DBS), implantable cortical nerve stimulation (CNS), implantable spinal cord stimulation (SCS), implantable sacral nerve stimulation (SNS), and / or implantable vagus nerve stimulation (VNS). An implantable neurostimulation system comprises a stimulator implanted within the target body (i.e., an implantable neurostimulator) and a programmed device positioned outside the target body. In other words, the stimulator is a medical device, or medical devices include stimulators. The relevant neuromodulation technology mainly involves implanting electrodes (electrodes in the form of electrode wires) at specific sites (i.e., target points, also known as target nuclei) in the tissue of an organism through stereotactic surgery. Electrical stimulation is then delivered to the target point through the electrodes to regulate the electrical activity and function of the corresponding neural structures and networks.

[0028] DBS (Deep Brain Stimulation) may include an implantable pulse generator (IPG), extension leads, and electrode leads. The IPG is connected to the electrode leads via the extension leads. The IPG can be implanted into the target body, such as in the chest or other internal locations. Alternatively, DBS may include an IPG and a lead body, with the IPG directly connected to the lead body. The IPG is implanted in the target head, for example, by creating a groove in the skull and placing the IPG within that groove. In this case, the IPG may not protrude from the skull surface or may partially protrude. The IPG responds to programmed commands from a programmable device, using a sealed battery and circuitry to provide controllable electrical stimulation (or electrical stimulation energy) to the target body's tissues. The IPG delivers one or more controllable electrical stimuli to specific areas of the tissue via the lead body. The extension leads, used in conjunction with the IPG, act as a medium for transmitting the electrical stimulation, conveying the stimulation generated by the IPG to the lead body.

[0029] Electrical stimulation can be delivered in the form of pulsed signals or non-pulsed signals. For example, electrical stimulation can be delivered as signals with various waveforms, frequencies, and amplitudes. Therefore, non-pulsed electrical stimulation can be a continuous signal, which can have a sinusoidal waveform or other continuous waveforms. After receiving electrical stimulation transmitted by the IPG or extension leads, the lead body delivers the electrical stimulation to a specific area of ​​the body tissue through multiple electrode contacts. The stimulator may have one or more lead bodies on one or both sides, with multiple electrode contacts on the lead body. The electrode contacts can be uniformly or non-uniformly arranged around the circumference of the lead body. The electrode contacts can be arranged in a 4x3 array (a total of 12 electrode contacts) around the circumference of the lead body. The electrode contacts may include stimulating electrode contacts and / or collecting electrode contacts, and the electrode contacts may be in the form of sheets, rings, or dots.

[0030] The stimulated tissue can be the target brain tissue, and the stimulated site can be a specific area of ​​the brain tissue. Generally, the stimulated site differs depending on the target object. The number of stimulation points (single-source or multi-source), the application of one or more specific electrical stimulation pathways (single-channel or multi-channel), and the stimulation parameters (values) also vary. There are no restrictions on the type of target tissue to which stimulation is applicable; it can include deep brain stimulation (DBS), spinal cord stimulation (SCS), sacral nerve stimulation, gastric stimulation, peripheral nerve stimulation, and / or functional electrical stimulation, etc.

[0031] Currently, in the DBS process, the operator directly selects stimulation parameters based on the individual circumstances of the target object to optimize the stimulation effect. However, this method lacks an intuitive and accurate stimulation parameter feedback mechanism, which may lead to low accuracy of the stimulation parameters used for electrical stimulation. This may result in the electrical stimulation range being too large or too small for the target object, thus affecting the stimulation effect of the electrical stimulation on the target object or even producing side effects.

[0032] To address this, embodiments of this disclosure can display a target electric field model generated based on the target stimulus parameters, allowing the operator to accurately adjust the target stimulus parameters based on the displayed target electric field model, thereby improving the accuracy of the stimulus parameters used. This will be described in detail below.

[0033] Figure 1 This is a structural block diagram of a programmable device provided in an embodiment of this disclosure. This embodiment is applicable to situations involving electrical stimulation of a target object.

[0034] See Figure 1The programmable device 110 of this embodiment is communicatively connected to the stimulator 120 implanted in the body of the target object. The programmable device 110 includes: a display interface 1101 and a processor 1102.

[0035] The display interface 1101 includes a display unit 11011 for displaying at least a postoperative brain model of the target object, an operation unit 11012 for selecting parameters for the operation object, and a programmable control unit 11013 for delivering stimulation commands to the stimulator; wherein...

[0036] The processor 1102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameters selected by the operating object on the operating unit 11012, so that the operating object can adjust the target stimulation parameters on the operating unit 11012 based on the target electric field model displayed on the display unit 11011, and send the target stimulation parameters to the stimulator 120 in a soft output mode when the operating object triggers the programmable control unit 11013.

[0037] In this embodiment, the programmable device 110 may include a doctor's programmable device (i.e., the programmable device 110 used by the doctor) and / or a user's programmable device (i.e., the programmable device used by the patient). In this application, the programmable device can be a doctor's programmable device, and correspondingly, the doctor operating the programmable device 110 can be referred to as the operating object. The doctor's programmable device is, for example, a smart terminal device such as a tablet computer, laptop computer, desktop computer, and / or mobile phone equipped with programmable software.

[0038] In this embodiment of the disclosure, the programmable device 110 can be communicatively connected to the stimulator 120 implanted in the target body. That is, the programmable device 110 can be used to adjust one or more stimulation parameters of the stimulator 120 (or one or more stimulation parameters of the pulse generator, with different stimulation parameters corresponding to different electrical stimuli) so that the stimulator 120 delivers electrical stimulation to the implanted electrode according to the adjusted stimulation parameters to provide electrical stimulation to the target body.

[0039] The target object can be understood as the person who has been implanted with the stimulator 120 and requires electrical stimulation. This can be a patient, whose symptoms may vary and the location of the implanted electrode may also vary.

[0040] Display interface 1101 can be understood as an interface with display function.

[0041] Processor 1102 can be understood as a processor 1102 with processing capabilities.

[0042] A postoperative brain model can be understood as a model of the brain of the target patient after surgery, where implanted electrodes have been placed.

[0043] In this embodiment, the processor 1102 can read medical images of the target object, such as magnetic resonance imaging (MRI) or computed tomography (CT) images, and convert the medical images to a three-dimensional spatial coordinate system to obtain coordinate data. Through image processing algorithms, it automatically identifies brain tissue (such as nuclei, cerebrospinal fluid, etc.) in the medical images and determines the location of the brain tissue in the medical images based on the identification results. The brain tissue includes at least a target nucleus associated with the patient's condition, which can be understood as an area of ​​the target object's brain that requires electrical stimulation. Based on the location and coordinate data, it determines at least one of the coordinates and shape of the brain tissue in the three-dimensional spatial coordinate system. The coordinates and shape of brain tissue in a three-dimensional spatial coordinate system determine the location data of the brain tissue in the brain. The location data represents the position of the target nucleus, which has a certain matching relationship with the position of the implanted electrode in the brain, thereby ensuring that electrical stimulation can be accurately applied to the target nucleus. Based on medical images, coordinate data, and location data, a postoperative brain model including the target nucleus can be generated. The generation of the postoperative brain model including the target nucleus can also display the target nucleus when the postoperative brain model is displayed in a subsequent manner, so that the patient can more accurately adjust the target stimulation parameters by using the displayed target nucleus and target electric field model.

[0044] It should be understood that the patient's postoperative medical images may include some features of the implanted electrode. Of course, different cross-sections in CT images may contain different features. An electrode model of the implanted electrode (including electrode wires and electrode contacts) in the patient's brain can be simulated based on the electrode features in the medical images. The electrode model and the patient's brain tissue module are then registered and fused to obtain the patient's postoperative brain model.

[0045] The display unit 11011 can be understood as a unit that displays at least a postoperative brain model; in addition to displaying the postoperative brain model, the display unit can also display at least one of the target electric field model, the initial electric field model, and the overlap rate display box, so that the operator can learn more information through the content displayed by the display unit, thereby facilitating more accurate adjustment or setting of parameters related to electrical stimulation.

[0046] The object of operation can be understood as the object that operates the programmable control equipment 110.

[0047] Parameter selection can be understood as the operation of selecting the target stimulus parameters.

[0048] Operation unit 11012 can be understood as a unit that can be operated on by the operation object.

[0049] The stimulation instruction can be understood as an instruction delivered to the stimulator 120 to cause the stimulator 120 to perform electrical stimulation on the target object.

[0050] The programmable control unit 11013 can be understood as a unit that delivers stimulation instructions to the stimulator 120.

[0051] The target stimulation parameters can be understood as the parameters involved in causing the stimulator 120 to stimulate the target object. The target stimulation parameters may include at least one of the following: an electrode contact combination for delivering electrical stimulation (the electrode contact combination may include at least one electrode contact identifier, such as electrode contact #2 and electrode contact #3) and electrode stimulation parameters; the electrode stimulation parameters may include at least one of the following: frequency (e.g., the number of electrical stimulation pulse signals per unit time 1 second, in Hz), pulse width (the duration of each pulse, in μs), amplitude (generally expressed as voltage, i.e., the intensity of each pulse, in V), timing (e.g., continuous or clustered, clustering refers to discontinuous temporal behavior composed of multiple processes), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode, and cyclic stimulation mode), upper and lower limits of control for the operator (the adjustable range of the operator), and upper and lower limits of control for the target object (the range that the target object can autonomously adjust).

[0052] The target electric field model can be understood as an electric field model generated based on the target stimulus parameters; the target electric field model can also be understood as a model representing the spatial distribution of the volume of activated tissue (VTA), which represents the range of influence of the electric field generated by the electrical stimulation on the brain tissue under the electrical stimulation corresponding to the target stimulus parameters.

[0053] In this embodiment of the present disclosure, the processor 1102 can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameters selected by the operating object on the operation unit 11012, so that the operating object can adjust the target stimulation parameters on the operation unit 11012 based on the target electric field model displayed on the display unit 11011. The process of generating the target electric field model can be as follows: the processor 1102 can calculate the spatial distribution of the VTA under electrical stimulation based on the target stimulation parameters and the principle of a physical model (such as an electric field model). For example, it can dynamically calculate the spatial distribution based on the location of the implanted electrode in the brain, the target stimulation parameters, and the brain structure. Based on the spatial distribution, the processor 1102 can generate the target electric field model (for example, it can be represented in the form of a three-dimensional VTA range). Alternatively, the processor 1102 can acquire individualized data of the target object (individualized data may include at least one of the following: medical images of the brain, three-dimensional coordinates of the target nucleus in a three-dimensional coordinate system, and the location of the implanted electrode in the brain), electrode parameters (electrode parameters may include at least one of the following: the type, polarity, size, material, and electrode spacing of the implanted electrode), and brain tissue characteristics (at least one of the following: tissue conductivity, dielectric constant, and anisotropy characteristics of the brain). Based on the target stimulation parameters, individualized data, electrode parameters, and brain tissue characteristics, the processor 1102 can determine at least one candidate stimulation parameter and generate the target electric field model that is superimposed on the postoperative brain model displayed on the display unit 11011.

[0054] In this embodiment of the present disclosure, before the processor 1102 generates the target electric field model, the target stimulus parameters selected by the operating object on the operation unit 11012 can be obtained. It should be noted that these target stimulus parameters can be selected by the operating object from at least one candidate stimulus parameter displayed on the operation unit 11012; this method of selecting target stimulus parameters can help the operating object efficiently select the target stimulus parameters. Alternatively, the operating object can directly input the target stimulus parameters through the operation unit 11012; this method of selecting target stimulus parameters can help obtain target stimulus parameters that better meet the needs of the operating object.

[0055] In this embodiment, after the user adjusts the target stimulation parameters on the operation unit 11012 based on the target electric field model displayed on the display unit 11011, the target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 can be updated in real time based on the target stimulation parameters. This allows the user to adjust the target stimulation parameters on the operation unit 11012 based on the updated target electric field model displayed on the display unit 11011, and repeat the step of updating the target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameters until the user considers the target stimulation parameters to be accurate and no longer adjusts them. The above-mentioned process of dynamically adjusting the target electric field model displayed on the display unit 11011 in real time allows the user to understand the target electric field model under the current target stimulation parameters, thereby facilitating more accurate adjustment of the target stimulation parameters.

[0056] In this embodiment of the disclosure, the display unit 11011 can also display the changes in the target electric field model under different target stimulus parameters (e.g., the target stimulus parameters before and after adjustment, or multiple sets of different target stimulus parameters to be selected, etc.), so as to provide more information for the operation object to adjust the target stimulus parameters.

[0057] In this embodiment of the disclosure, the selection and / or adjustment of the target stimulation parameters can be performed in current mode or voltage mode, so that the voltage or current of the electrical stimulation delivered to the patient can be more precise through the selection and / or adjustment of the target stimulation parameters.

[0058] Soft output mode can be understood as a mode of progressively delivering target stimulation parameters. This is because when delivering electrical stimulation to the brain nuclei, if a high stimulation intensity is suddenly delivered, it may cause significant discomfort to the patient, which is not conducive to subsequent treatment and the doctor's accurate control of the patient's treatment. The soft output module can deliver electrical stimulation to the patient in a progressive manner, allowing the patient to gradually adapt to the stimulation intensity and improving the patient's treatment experience.

[0059] In this embodiment of the disclosure, the processor 1102 can send the target stimulation parameters to the stimulator 120 in a soft output mode when the operation object triggers the programmable control unit 11013.

[0060] For example, the processor 1102 can generate a target electric field model superimposed on the display unit 11011 based on the target stimulation parameters selected by the operating object through the operation unit 11012. The display unit 11011 can display the postoperative brain model and the target electric field model superimposed on the postoperative brain model, so that the operating object can adjust the target stimulation parameters through the operation unit 11012 based on the target electric field model displayed on the display unit 11011 (if the operating object believes that the target stimulation parameters are accurate based on the target electric field model displayed on the display unit 11011, the target stimulation parameters may not be adjusted). When the operating object triggers the program control unit 11013, the processor 1102 can send the target stimulation parameters to the stimulator 120 in a soft output mode through a stimulation command, so that the stimulator 120 can perform electrical stimulation on the target object according to the target stimulation parameters.

[0061] In this embodiment of the disclosure, the processor 1102 may also be configured to sense the electrophysiological activity of the target object through the stimulator 120 to acquire electrophysiological signals, and adjust the target stimulation parameters according to the electrophysiological activity and electrophysiological signals to achieve closed-loop control (or adaptive adjustment) of the target stimulation parameters.

[0062] The solutions disclosed herein can be applied to the field of biomedical engineering, specifically to medical fields such as neuromodulation and electrical stimulation therapy.

[0063] The programmable device 110 of this embodiment can provide an efficient, intuitive and user-friendly display interface 1101 for the user, allowing the user to freely adjust the target stimulation parameters and view real-time electric field model feedback. This helps the user understand the specific effects of electrical stimulation on brain tissue through the displayed target electric field model, thereby enabling the user to accurately adjust the target stimulation parameters based on the displayed target electric field model. This improves the accuracy of the stimulation parameters used, avoids excessive or insufficient electrical stimulation, reduces unnecessary side effects, and ensures the safety and effectiveness of electrical stimulation.

[0064] Optionally, the operation unit 11012 includes at least a stimulation parameter adjustment control to adjust a target stimulation parameter, wherein the target stimulation parameter being adjusted includes at least one of frequency, pulse width, and amplitude.

[0065] The stimulus parameter adjustment control can be understood as a control used to adjust the target stimulus parameters.

[0066] In this embodiment of the present disclosure, the operation unit 11012 includes at least a stimulation parameter adjustment control to adjust the target stimulation parameter. The target stimulation parameter to be adjusted includes at least one of the frequency, pulse width, and amplitude of the electrical stimulation, so as to provide an adjustment function for at least one of the frequency, pulse width, and amplitude of the electrical stimulation. The adjustment of at least one of the frequency, pulse width, and amplitude of the electrical stimulation can effectively adjust the intensity dimension of the electrical stimulation, thereby improving the patient's treatment experience.

[0067] The technical solution of this disclosure embodiment includes a programmable device that can communicate with a stimulator implanted in the target body. The programmable device includes a display interface and a processor. The display interface includes at least a display unit displaying a postoperative brain model of the target body, an operation unit for the user to select parameters, and a programmable unit for delivering stimulation commands to the stimulator. The processor can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit, based on the target stimulation parameters selected by the user on the operation unit. This allows the user to adjust the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit. When the user triggers the programmable unit, the target stimulation parameters are sent to the stimulator in a soft-output mode to achieve electrical stimulation of the target body. This technical solution allows for the display of a target electric field model generated based on the target stimulation parameters, enabling the user to accurately adjust the target stimulation parameters based on the displayed model, thereby improving the accuracy of the stimulation parameters used.

[0068] In one optional technical solution, at least one implanted electrode is implanted at a target nucleus in the brain of the target subject. The stimulator is configured to deliver electrical stimulation to at least a portion of the implanted electrode. The target stimulation parameters include electrode contact combinations and electrode stimulation parameters. The processor is further configured to generate a target electric field model superimposed on a postoperative brain model displayed on a display unit based on the target stimulation parameters selected by the subject on the operating unit. This allows the subject to adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit. When the subject triggers the programming unit, the electrode contact combinations and electrode stimulation parameters are sent to the stimulator in a soft-output mode, so that the stimulator delivers electrical stimulation to the implanted electrode corresponding to the electrode contact combination according to the electrode stimulation parameters to electrically stimulate the target nucleus.

[0069] The implanted electrode can be understood as an electrode implanted in the target nucleus of the brain; through the implanted electrode implanted in the brain, electrical stimulation of the target can be achieved.

[0070] An electrode contact combination can be understood as a combination of contacts on an implanted electrode that is required to deliver electrical stimulation. Different electrode contact combinations result in different ranges of influence of the electric field generated by electrical stimulation on brain tissue. Adjusting the electrode contact combination can effectively adjust the range of influence of electrical stimulation on the brain.

[0071] Electrode stimulation parameters can be understood as the parameters used for electrical stimulation; for example, electrode stimulation parameters may include at least one of the following: current intensity, frequency, pulse width, and amplitude of electrical stimulation.

[0072] In this embodiment, at least one implanted electrode is implanted at the target nucleus. The stimulator is configured to deliver electrical stimulation to at least a portion of the implanted electrode. The target stimulation parameters include electrode contact combinations and electrode stimulation parameters. A processor generates a target electric field model superimposed on a postoperative brain model displayed on a display unit, based on the target stimulation parameters selected by the user on the operating unit. This allows the user to adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit. When the user triggers the programming unit, the electrode contact combinations and electrode stimulation parameters are sent to the stimulator in a soft-output mode, so that the stimulator delivers electrical stimulation to the implanted electrode corresponding to the electrode contact combination according to the electrode stimulation parameters, thereby electrically stimulating the target nucleus. This technical solution allows for more precise electrical stimulation of the target nucleus using target stimulation parameters that include electrode contact combinations and electrode stimulation parameters.

[0073] Based on the above solution, another optional technical solution is that the display unit further includes an overlap rate display frame, which is configured to display the overlap rate between the target electric field model and the target nucleus.

[0074] For example, see Figure 2 The overlap rate display box can be understood as a box that displays the overlap rate. This box can exist in the form of a pop-up window and does not affect the display of the target nucleus and the target electric field model.

[0075] The overlap rate can be understood as the overlap rate between the target electric field model and the target nucleus. By displaying the overlap rate, doctors can be quickly alerted to the degree of influence of the current stimulation parameters on the target nucleus, which is conducive to quickly adjusting the stimulation parameters and improving the efficiency and convenience of programming.

[0076] In this embodiment of the present disclosure, the postoperative brain model may include the target nucleus. When the postoperative brain model is displayed on the display unit, the target nucleus can also be displayed. In addition, the display unit can also display the overlapping area between the target nucleus and the target electric field model, so as to intuitively display the VTA range of the electrical stimulation represented by the target electric field model and its relationship with the target nucleus on the display interface, so that the operator can clearly understand the size and shape of the target electric field model and its spatial overlap with the target nucleus, providing a basis for the operator to adjust the target stimulation parameters.

[0077] In this embodiment of the disclosure, the display unit can also display the coverage area of ​​the target electric field model, the location of the target nucleus, and the relationship between the target nucleus and the target electric field model, etc., so that the operator can understand more relevant information that can characterize whether the target stimulus parameters are accurate, thereby facilitating more accurate adjustment of the target stimulus parameters.

[0078] In this embodiment of the present disclosure, the processor can also be configured to adjust the content displayed on the display unit according to the operation command when the operation object triggers an operation command such as rotation or scaling on the display unit, so that the operation object can more accurately view the spatial comparison between the target nucleus and the target electric field model in real time, so as to further optimize and adjust the target stimulation parameters.

[0079] In this embodiment, the display unit may include an overlap rate display frame, which can display the overlap rate between the target electric field model and the target nucleus. The above technical solution, through the display of the overlap rate, provides a basis for more accurate adjustment of the target stimulus parameters.

[0080] Another alternative technical solution is that the processor is also configured to send the adjusted target stimulation parameters to the stimulator in a soft-output mode when the operating object adjusts the target stimulation parameters on the operating unit according to the second object feedback of the target object, so that the stimulator adjusts the electrical stimulation of the target object according to the adjusted target stimulation parameters.

[0081] The second object feedback can be understood as the target object's feedback to itself; the second object feedback may include, for example, the target object's physiological indicators and / or subjective feelings, etc.

[0082] In this embodiment, the processor can send the adjusted target stimulation parameters to the stimulator in a soft-output mode when the target object adjusts the target stimulation parameters on the operation unit based on feedback from the second object. This allows the stimulator to adjust the electrical stimulation applied to the target object according to the adjusted target stimulation parameters. This technical solution enables the electrical stimulation applied to the target object to be more consistent with the target object's actual condition. In particular, it allows for timely adjustment of the target stimulation parameters when the second object feedback indicates discomfort in the target object, thus ensuring the electrical stimulation better matches the target object's actual condition and preventing discomfort.

[0083] Figure 3 This is a structural block diagram of another programmable device provided in this embodiment. This embodiment is an optimization based on the above-described technical solutions. In this embodiment, optionally, the processor is further configured to: before sending the target stimulation parameters to the stimulator in a soft-output mode, if the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, update the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate; send the initial stimulation parameters to the stimulator in a soft-output mode so that the stimulator performs electrical stimulation on the target object according to the initial stimulation parameters; and repeatedly execute the step of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters. The explanations of terms that are the same as or corresponding to those in the above embodiments are not repeated here.

[0084] For details, see Figure 3 In this embodiment, the programmable device 210 is communicatively connected to the stimulator 220 implanted in the target body. The programmable device includes: a display interface 2101 and a processor 2102.

[0085] The display interface includes a display unit 21011 for displaying at least a postoperative brain model of the target object, an operation unit 21012 for selecting parameters for the operation object, and a programmable control unit 21013 for delivering stimulation commands to the stimulator; wherein...

[0086] The processor 2102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 21011 based on the target stimulation parameters selected by the operating object on the operating unit 21012, so that the operating object can adjust the target stimulation parameters on the operating unit 21012 based on the target electric field model displayed on the display unit 21011, and send the target stimulation parameters to the stimulator 220 in a soft output mode when the operating object triggers the programmable control unit 21013;

[0087] The processor 2102 is also configured to: before sending the target stimulation parameters to the stimulator 220 in a soft-output mode, update the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate if the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters; send the initial stimulation parameters to the stimulator 220 in a soft-output mode so that the stimulator 220 provides electrical stimulation to the target object according to the initial stimulation parameters; and repeat the step of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate if the initial stimulation parameters of the stimulator 220 are less than or equal to the target stimulation parameters.

[0088] The initial stimulation parameters can be understood as the stimulation parameters used by the stimulator to initially electrically stimulate the target object, or the stimulation parameters used by the stimulator to electrically stimulate the target object before using the target stimulation parameters.

[0089] The parameter adjustment rate can be understood as the rate at which the initial stimulation parameters are adjusted; it can also be understood as the rate at which the electrical stimulation changes during the gradual delivery of electrical stimulation to the patient. By setting an appropriate parameter adjustment rate, electrical stimulation can be delivered to the patient gradually at a suitable speed, allowing the patient to gradually adapt to the intensity of the stimulation and improving the patient's treatment experience.

[0090] It should be noted that in the embodiments of this disclosure, the determination that the initial stimulus parameter is less than or equal to the target stimulus parameter, and the adjustment of the initial stimulus parameter, the stimulus parameter to be determined or adjusted may not be all the stimulus parameters. Specifically, the stimulus parameter to be determined or adjusted may be at least one of the initial stimulus parameters such as current intensity, frequency, pulse width, and amplitude, which can be adjusted and compared.

[0091] The technical solution of this disclosure involves the processor updating the initial stimulation parameters according to the initial stimulation parameters and parameter adjustment rate before sending the target stimulation parameters to the stimulator in soft output mode, provided that the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters. Then, the initial stimulation parameters are sent to the stimulator in soft output mode, allowing the stimulator to perform electrical stimulation on the target object according to the initial stimulation parameters. Finally, the step of updating the initial stimulation parameters according to the initial stimulation parameters and parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters is repeated. This technical solution adds a mechanism for progressively adjusting the stimulation parameters by adjusting the initial stimulation parameters and parameter adjustment rate until the target stimulation parameters are reached. This provides an adaptation process for the target object, avoiding discomfort or side effects caused by directly stimulating the target object according to the electrical stimulation corresponding to the target stimulation parameters.

[0092] An alternative technical solution is that the processor is further configured to: when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, before updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, generate an initial electric field model superimposed on the postoperative brain model displayed on the display unit based on the initial stimulation parameters; and after updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, adjust the initial electric field model displayed on the display unit based on the initial stimulation parameters.

[0093] The initial electric field model can be understood as an electric field model generated based on the initial stimulus parameters.

[0094] In this embodiment of the disclosure, by means of a processor, when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, before updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, an initial electric field model is generated based on the initial stimulation parameters and superimposed on the postoperative brain model displayed on the display unit. After updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, the initial electric field model displayed on the display unit is adjusted based on the initial stimulation parameters. This can provide the operating object with a progressively enhanced and visualized initial electric field model so that the operating object can understand the degree of electrical stimulation to the target object.

[0095] Another alternative technical solution is that the processor is also configured to update the parameter adjustment rate based on the adjustment result obtained when the operation object adjusts the parameter adjustment rate on the operation unit according to the first object feedback of the target object.

[0096] The first object feedback can be understood as the relevant feedback of the target object to itself when it is electrically stimulated according to the initial stimulation parameters; for example, it may include physiological indicators and / or subjective feelings, etc.

[0097] In this embodiment of the disclosure, by updating the parameter adjustment rate based on the adjustment result when the operating object adjusts the parameter adjustment rate on the operating unit according to the feedback from the first object, the controllability of the electrical stimulation change process can be increased. When the feedback from the first object indicates that the target object has discomfort, the parameter adjustment rate can be updated in a timely manner to avoid discomfort or side effects caused to the target object by the parameter adjustment rate that does not meet the needs of the target object.

[0098] Figure 4 This is a structural block diagram of another programmable device provided in this disclosure. This embodiment is based on and optimized from the above-described technical solutions. In this embodiment, optionally, the processor is further configured to determine at least one similar case from at least one candidate case that is similar to the target case of the target object, and to determine candidate stimulus parameters corresponding to the at least one similar case displayed on the operation unit, so that the target object can select the target stimulus parameter from the at least one candidate stimulus parameter on the operation unit. The explanations of terms that are the same as or corresponding to those in the above embodiments are not repeated here.

[0099] For details, see Figure 4 In this embodiment, the programmable device 310 is communicatively connected to the stimulator 320 implanted in the target body. The programmable device includes: a display interface 3101 and a processor 3102.

[0100] The display interface 3101 includes a display unit 31011 for displaying at least a postoperative brain model of the target object, an operation unit 31012 for selecting execution parameters for the operation object, and a programmable control unit 31013 for delivering stimulation commands to the stimulator; wherein...

[0101] The processor 3102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 31011 based on the target stimulation parameters selected by the operating object on the operating unit 31012, so that the operating object can adjust the target stimulation parameters on the operating unit 31012 based on the target electric field model displayed on the display unit 31011, and send the target stimulation parameters to the stimulator 320 in a soft output mode when the operating object triggers the programmable unit.

[0102] The processor 3102 is further configured to determine at least one similar case from at least one alternative case that is similar to the target case of the target object, and to determine candidate stimulus parameters corresponding to the at least one similar case displayed on the operation unit 31012, so that the target object can select the target stimulus parameter from the at least one candidate stimulus parameter on the operation unit 31012.

[0103] Here, alternative cases can be understood as cases that are considered as similar cases; alternative cases may be, for example, cases of alternative subjects who have been electrically stimulated.

[0104] The target case can be understood as the case of the target subject.

[0105] Similar cases can be understood as alternative cases that are similar to the target case.

[0106] In this embodiment of the disclosure, processor 3102 can determine at least one similar case that is similar to the target case of the target object from at least one candidate case. For example, processor 3102 can retrieve at least one similar case that is similar to the target case of the target object from at least one candidate case in an electrical stimulation parameter database.

[0107] The candidate stimulation parameters can be understood as the stimulation parameters used when the candidate subjects corresponding to similar cases are electrically stimulated.

[0108] It is understandable that, since the similarity ratio is similar to that of the target case, the candidate stimulus parameters used in the similar cases are also likely to be the target stimulus parameters that the target cases can use. Therefore, the processor 3102 can determine the candidate stimulus parameters corresponding to at least one similar case displayed on the operation unit 31012, so that the operation object can select the target stimulus parameter from at least one candidate stimulus parameter on the operation unit 31012.

[0109] In this embodiment of the disclosure, at least one similar case displayed on the operation unit 31012 can be identified as corresponding to case stimulation parameters. Based on the case stimulation parameters corresponding to at least one similar case, a range of stimulation parameters is determined. Based on the range of stimulation parameters, at least one candidate stimulation parameter is determined so that the operator can select a target stimulation parameter from the at least one candidate stimulation parameter on the operation unit 31012. Determining at least one candidate stimulation parameter based on the range of stimulation parameters can avoid the situation where the number of case stimulation parameters corresponding to at least one similar case is too small or too discrete, making it difficult to provide more and more comprehensive options for the operator to select.

[0110] In this embodiment of the present disclosure, the processor 3102 may also determine, for each candidate stimulation parameter, a candidate electric field model displayed on the display unit 31011, so that the operator can understand the range of influence of electrical stimulation on the brain under each candidate stimulation parameter, so that the operator can select a target stimulation parameter from at least one candidate stimulation parameter on the operation unit 31012 based on the candidate electric field model corresponding to at least one candidate stimulation parameter displayed.

[0111] The technical solution of this disclosure involves a processor determining at least one similar case from at least one candidate case that is similar to the target case, and determining candidate stimulus parameters corresponding to each of the at least one similar case displayed on an operating unit, so that the user can select the target stimulus parameter from the at least one candidate stimulus parameter on the operating unit. This technical solution can provide at least one optimal candidate stimulus parameter tailored to the individual differences of the target user, thereby helping to further improve the accuracy of the stimulus parameters used.

[0112] An optional technical solution, the processor, is further configured to: for each of the at least one similar cases, determine a similar electric field model of the similar case; superimpose the similar electric field model onto a postoperative brain model with a defined reference electric field region; determine the overlap rate between the similar electric field model superimposed on the postoperative brain model and the reference electric field region; determine a target candidate case from the at least one similar case based on the overlap rate corresponding to the at least one similar case; and update the at least one similar case based on the target candidate case.

[0113] The similar electric field model can be understood as an electric field model generated based on the corresponding candidate stimulus parameters of similar cases.

[0114] The reference electric field region can be understood as the region in the postoperative brain model corresponding to the brain region that requires electrical stimulation.

[0115] The overlap rate can be understood as the overlap rate between the similar electric field model and the reference electric field region.

[0116] In this embodiment of the disclosure, the processor can determine a similar electric field model for each similar case. For example, the processor can determine the similar electric field model based on the candidate stimulus parameters, individualized data, electrode parameters and brain tissue characteristics corresponding to the similar case. The similar electric field model is superimposed on the postoperative brain model with the reference electric field region defined, and the overlap rate is determined. For example, the similar electric field model can be superimposed on the postoperative brain model with the reference electric field region defined in a three-dimensional voxel mesh, and the voxel overlap rate between the voxel volume corresponding to the similar electric field model and the voxel volume corresponding to the reference electric field region can be calculated.

[0117] The target candidate cases can be understood as similar cases used to update at least one similar case; the number of target candidate cases can be at least one.

[0118] In this embodiment of the present disclosure, the processor can determine target candidate cases from at least one similar case based on the overlap rate corresponding to at least one similar case. For example, a preset number of similar cases with the highest overlap rate (e.g., 3-5) or similar cases with an overlap rate greater than the preset overlap rate can be used as target candidate cases to ensure that the subsequent target electric field model coverage is as accurate as possible, and at least one similar case is updated based on the target candidate cases.

[0119] In this embodiment of the disclosure, the processor can update at least one similar case based on the target candidate case; for example, the target candidate case can be updated to at least one similar case.

[0120] In this embodiment of the present disclosure, the display unit may also display the degree of matching between at least one candidate stimulus parameter and the reference electric field region (which can be determined according to the overlap rate corresponding to the candidate stimulus parameter), so that the operator can select the target stimulus parameter from at least one candidate stimulus parameter on the operation unit based on the displayed degree of matching between at least one candidate stimulus parameter. By displaying the degree of matching, the operator can be quickly reminded whether each candidate stimulus parameter matches the reference electric field region, which is conducive to quickly selecting the target stimulus parameter and improving the efficiency and convenience of program control.

[0121] For example, referring to Table 1 below, the display unit can display at least one candidate stimulus parameter (current intensity in Table 1) and the matching degree corresponding to each candidate stimulus parameter, so that the operating object can select the most suitable target stimulus parameter from the at least one candidate stimulus parameter on the operating unit based on the above content displayed by the display unit.

[0122] Table 1 shows the content displayed by the unit.

[0123] 1 1.2 92％ 2 2.0 88％ 3 1.8 95％ 4 2.5 85％

[0124] In this embodiment, a processor determines a similar electric field model for each similar case, superimposes the similar electric field model onto a postoperative brain model with a pre-defined reference electric field region, determines the overlap rate, and then, based on the overlap rate corresponding to at least one similar case, determines a target candidate case from at least one similar case, and updates at least one similar case based on the target candidate case. This technical solution can identify similar cases that better satisfy the brain region corresponding to the reference electric field region defined by the electrical stimulation, thereby helping to provide at least one candidate stimulation parameter for the brain region corresponding to the reference electric field region defined by the electrical stimulation, and further improving the accuracy of the stimulation parameters used.

[0125] Based on the above solution, another optional technical solution, the display unit, is further configured to display the postoperative brain model before superimposing the similar electric field model onto the postoperative brain model with the already determined reference electric field region, so that the operating object can define the reference electric field region in the displayed postoperative brain model.

[0126] In this embodiment of the disclosure, the reference electric field region can be manually defined by the operator in the displayed postoperative brain model. For example, the processor can divide the postoperative brain model or medical image into multiple voxels according to spatial resolution based on individualized data such as the location of the implanted electrodes in the brain, and obtain an interactive three-dimensional voxel grid corresponding to the brain displayed on the operating unit. This allows the operator to define or adjust the reference electric field region (which usually covers the target nucleus) in the three-dimensional voxel grid displayed on the operating unit based on clinical experience, specific stimulation requirements, or specific neuroanatomical structures, through mouse or touch screen operation. The voxel is a small cube in three-dimensional space, and each voxel represents a tiny volume unit of brain tissue. It can be used for fine electric field calculations. The size and number of voxels are closely related to the resolution of the postoperative brain model or medical image.

[0127] In this embodiment of the disclosure, the postoperative brain model can be displayed by the display unit before the similar electric field model is superimposed on the postoperative brain model with the determined reference electric field region, so that the operating object can define the reference electric field region in the displayed postoperative brain model, thereby providing the operating object with the function of defining the reference electric field region.

[0128] To better understand the technical solutions of the embodiments of this disclosure, an optional example is provided here. For example, depending on the target object having different stimulus needs and adaptability, the programmable device can provide two modes for the object to choose from, including Mode 1 and Mode 2.

[0129] When the operation object is selected as mode one, see [link / reference]. Figure 5The left side of the User Interface (UI) view operation unit allows the user to select appropriate electrode contact combinations from the target stimulation parameters. The display unit can show a three-dimensional (3D) view of the postoperative brain model. When the user selects an electrode contact combination, the activation effect of the corresponding implanted electrode can be overlaid on the display unit. The right side of the UI view operation unit allows the user to adjust the electrode stimulation parameters from the target stimulation parameters. After selecting an electrode contact combination, the user can manually adjust the electrode stimulation parameters through the operation unit. The display unit can show a 3D view of the target electric field model, which is generated based on the electrode contact combination and electrode stimulation parameters. When the target stimulation parameters are adjusted, the display unit can update the displayed target electric field model in real time, so that the user can immediately see the range of the target electric field model. The system monitors changes and determines whether the current target stimulus parameters meet the requirements. The UI view programmable unit can be used to initiate electrical stimulation. If the user believes that the range of the target electric field model has a high overlap with the target nucleus, the user can click the "Programmable" button on the programmable unit to initiate electrical stimulation. In this case, the processor automatically sends the current target stimulus parameters and the VTA range represented by the target electric field model to the stimulator. The stimulator will immediately initiate electrical stimulation according to the target stimulus parameters and VTA range. After applying electrical stimulation to the target object, the user can observe the target object's reaction and the changes in the displayed target electric field model in real time to determine whether adjustments are needed. If adjustments are needed, the user can continue to adjust the target stimulus parameters through the programmable unit and execute the step of sending the current target stimulus parameters and the VTA range represented by the target electric field model to the stimulator until the optimal electrical stimulation effect is achieved.

[0130] When the operation object is selected as mode two, see [link / reference]. Figure 6In Mode 2, the functions available on the display interface are the same as in Mode 1. However, after the user clicks the "Programming" button on the programmable unit, the processor will slowly and progressively increase the current intensity and / or other stimulation parameters based on the initial stimulation parameters. The increased initial stimulation parameters are then sent to the stimulator to ensure that the electrical stimulation intensity is low in the initial stage and that the increase is controlled within an adaptive range, ensuring that the target object can adapt to the physiological changes brought about by the electrical stimulation. The rate of increase of the current intensity and / or other stimulation parameters can be adjusted based on the displayed initial electric field model and the target object's initial feedback, increasing the controllability of the electrical stimulation process and avoiding discomfort or side effects caused by sudden changes in stimulation intensity. The display unit can display a 3D view of the initial electric field model, which can be generated from the initial stimulation parameters. The initial electric field model can gradually reach the shape of the target electric field model as the electrical stimulation progresses, giving the target object sufficient time to adapt to the electrical stimulation process and reducing the risk of discomfort and side effects.

[0131] Figure 7 This is a structural block diagram of a medical system provided in an embodiment of this disclosure. This embodiment is applicable to situations involving electrical stimulation of a target object.

[0132] See Figure 7 The medical system of this disclosure includes: a stimulator 410, which is implanted into the body of a target subject;

[0133] At least one implantable electrode 420, at least a portion of each implantable electrode 420 being implanted into a target nucleus in the brain of the target subject, the implantable electrode 420 being connected to a stimulator 410 and configured to deliver electrical stimulation to the target nucleus;

[0134] The programmable device 430 provided in any embodiment of this disclosure is communicatively connected to the stimulator 410.

[0135] The technical solution of this disclosure includes a stimulator implanted into the body of a target subject; at least one implanted electrode, at least a portion of which is implanted into a target nucleus in the brain of the target subject; the implanted electrode is connected to the stimulator and configured to deliver electrical stimulation to the target nucleus; and a programmable control device provided in any embodiment of this disclosure, which is communicatively connected to the stimulator. The above technical solution improves the accuracy of the stimulation parameters used by providing a programmable control device that can display a target electric field model generated based on the target stimulation parameters, allowing the subject to accurately adjust the target stimulation parameters based on the displayed target electric field model.

[0136] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A programmable control device, characterized in that, The programmable device is communicatively connected to a stimulator implanted in the body of a target individual, and includes: a display interface and a processor; The display interface includes a display unit for displaying at least a postoperative brain model of the target object, an operation unit for selecting parameters for the subject, and a programmable control unit for delivering stimulation commands to the stimulator; wherein... The processor is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameters selected by the operating object on the operating unit, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and send the target stimulation parameters to the stimulator in a soft output mode when the operating object triggers the programmable unit; The processor is also configured to: Before sending the target stimulation parameters to the stimulator in soft output mode, if the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, the initial stimulation parameters are updated according to the initial stimulation parameters and the parameter adjustment rate. The initial stimulation parameters are sent to the stimulator in a soft-output mode so that the stimulator can perform electrical stimulation on the target object according to the initial stimulation parameters. Repeat the step of updating the initial stimulation parameters based on the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters; The processor is also configured to: If the initial stimulation parameter of the stimulator is less than or equal to the target stimulation parameter, before updating the initial stimulation parameter according to the initial stimulation parameter and the parameter adjustment rate, an initial electric field model is generated based on the initial stimulation parameter and superimposed on the postoperative brain model displayed on the display unit. After updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, the initial electric field model displayed by the display unit is adjusted based on the initial stimulation parameters.

2. The programmable control equipment according to claim 1, characterized in that, The processor is further configured to update the parameter adjustment rate based on the adjustment result obtained when the operation object adjusts the parameter adjustment rate on the operation unit according to the first object feedback of the target object.

3. The programmable control equipment according to claim 1, characterized in that, The operation unit includes at least a stimulation parameter adjustment control to adjust the target stimulation parameter through the stimulation parameter adjustment control. The target stimulation parameter to be adjusted includes at least one of frequency, pulse width, and amplitude.

4. The programmable control equipment according to claim 1, characterized in that, The processor is further configured to determine, from at least one candidate case, at least one similar case that is similar to the target case of the target object, and to determine candidate stimulus parameters corresponding to each of the at least one similar case displayed on the operation unit, so that the target object can select the target stimulus parameter from the at least one candidate stimulus parameter on the operation unit.

5. The programmable control equipment according to claim 4, characterized in that, The processor is also configured to: For each of the at least one of the similar cases, a similar electric field model for the similar case is determined, the similar electric field model is superimposed on the postoperative brain model with a defined reference electric field region, and the overlap rate between the similar electric field model superimposed on the postoperative brain model and the reference electric field region is determined. Based on the overlap rate corresponding to at least one of the similar cases, a target candidate case is determined from at least one of the similar cases, and the at least one of the similar cases is updated based on the target candidate case.

6. The programmable control equipment according to claim 5, characterized in that, The display unit is further configured to display the postoperative brain model before superimposing the similar electric field model onto the postoperative brain model with the reference electric field region already defined, so that the operating object can frame the reference electric field region in the displayed postoperative brain model.

7. The programmable control equipment according to claim 1, characterized in that, At least one implanted electrode is implanted at a target nucleus in the brain of the target subject, and the stimulator is configured to deliver electrical stimulation to at least a portion of the implanted electrode, wherein the target stimulation parameters include electrode contact combinations and electrode stimulation parameters. The processor is further configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameters selected by the operating object on the operating unit. This allows the operating object to adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit. When the operating object triggers the programmable unit, the processor sends the electrode contact combination and the electrode stimulation parameters to the stimulator in a soft-output mode. This allows the stimulator to deliver electrical stimulation to the implanted electrode corresponding to the electrode contact combination according to the electrode stimulation parameters, thereby electrically stimulating the target nucleus.

8. The programmable control equipment according to claim 7, characterized in that, The display unit further includes an overlap rate display frame, which is configured to display the overlap rate between the target electric field model and the target nucleus.

9. The programmable control equipment according to claim 1, characterized in that, The processor is further configured to send the adjusted target stimulation parameters to the stimulator in a soft-output mode when the operating object adjusts the target stimulation parameters on the operating unit according to the second object feedback of the target object, so that the stimulator adjusts the electrical stimulation applied to the target object according to the adjusted target stimulation parameters.

10. A medical system, characterized in that, The system includes: The stimulator is implanted into the target subject's body; At least one implantable electrode, at least a portion of each implantable electrode being implanted into a target nucleus in the brain of the target subject, the implantable electrode being connected to the stimulator and configured to deliver electrical stimulation to the target nucleus; The programmable device according to any one of claims 1 to 9, wherein the programmable device is communicatively connected to the stimulator.

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