Acupuncture point massage essential oil for assisting smoke control and refreshing and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses acupoint massage essential oil for assisting in controlling smoke and refreshing and a preparation method of the acupoint massage essential oil. Comprising a monarch drug of galangal essential oil, a ministerial drug of lemon essential oil, an adjuvant drug of mint essential oil, an adjuvant drug of coenzyme Q10, an adjuvant drug of limonene, an adjuvant drug of linalool, an adjuvant drug of methyl cinnamate, a conductant drug of jojoba oil and a conductant drug of vanillin. Through synergistic improvement of a formula and a process, effective components of the massage essential oil enter a human body through mutual cooperation of smelling and acupoint massage, the activity of monoamine oxidase is rapidly inhibited, the fragrance is mild, the smell is pleasant, the massage essential oil is convenient to carry and use at any time, and the user experience and the psychological feeling during use are remarkably improved; when the cigarette holder is used, a user can feel pleasant during smoking, untoward effects and pains caused by smoking addiction are relieved, the number of smoking times can be gradually reduced, and the purposes of controlling smoking and quitting smoking are achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to an acupoint massage essential oil for assisting in smoking control and refreshing the spirit and a preparation method thereof, which can significantly improve user acceptance and compliance, reduce smokers' desire for smoking and boost their spirits. Background Art

[0002] Existing research shows that cigarettes contain nicotine. After long-term smoking addiction, the brain's severe physiological dependence on nicotine will cause continuous harm to the physical and mental health of smokers. Therefore, various tobacco control and smoking cessation products have emerged one after another. Functional products of replacement therapy include e-cigarettes, nicotine patches, nicotine gum, nicotine inhalers and nicotine sprays, etc., but these products may cause users to develop new dependence on them; Western medicine includes non-nicotine drugs such as bupropion (trade name: Lebitong) and varenicline (trade name: Changpei) and other drugs, but drug-based smoking cessation products may have side effects; Traditional Chinese Medicine products used for smoking cessation mainly include Chinese herbal teas, Chinese patent medicines, patches, lozenges, sprays, etc., such as common Chinese herbal teas include lotus leaf tea, wolfberry tea, etc., and Chinese patent medicines such as smoking cessation pills, smoking cessation syrups and other products, but they are usually easy to cause negative feelings (discomfort) in users.

[0003] Existing research shows that the effectiveness of conventional tobacco control and cessation products is often difficult to sustain. This is because quitting smoking requires a comprehensive, multifaceted behavioral modification process, combating both nicotine dependence and psychological addiction to smoking, as well as resisting various environmental temptations. Most existing self-use products, when used alone, cause significant negative reactions, low acceptance, and a reluctance to use them continuously, resulting in poor sustained effectiveness and high relapse rates. The medications used in smoking cessation clinics, primarily bupropion hydrochloride and nicotine patches, offer short-term benefits but are also difficult to sustain over the long term. For example, KR101126279B1 discloses a mixed essential oil composition and a method for preparing a smoking cessation aid using the composition. The mixed essential oil composition contains 25-35% bergamot oil, 20-30% coriander oil, 15-25% ginger oil, 5-20% sweet orange oil, and 5-20% lemon oil. The invention also provides toothpaste, sprays, and tubular smoking cessation aids produced using the mixed essential oil composition. However, these toothpastes, sprays, and pipe-shaped smoking cessation aids manufactured using the composition can easily cause discomfort and negative emotions in users. US5592956A discloses a composition and method for suppressing tobacco cravings. Applying a mixture of clove oil, wintergreen oil, sodium glutamate, Evodia rutaecarpa extract, and Ligusticum chuanxiong extract to specific acupuncture points on the human body can reduce or eliminate tobacco cravings. Attempting to use tobacco can cause nausea, headaches, dizziness, vomiting, and other discomforts, and can also easily trigger psychological resistance in users. CN101502596A discloses a smoking cessation drug, which is prepared by crushing a variety of Chinese medicinal raw materials with a Chinese medicine grinder and soaking them in 60-proof pure sorghum liquor. The drug will produce unacceptable odors, strange tastes, unique salty, bitter or spicy tastes in the mouth when the user smokes again, and is likely to cause negative feelings in the user, causing him to refuse to continue using the drug, thus failing to achieve the purpose.

[0004] Acupoint massage and olfactory therapy, as traditional Chinese medicine therapies, have potential for smoking cessation. Compound essential oils combine the efficacy of multiple essential oils and, through the dual effects of acupoint massage and olfactory therapy, are expected to become a safe and effective smoking cessation aid. However, existing compound essential oils have deficiencies in synergy, shelf life, and preparation processes. For example, the product is too irritating, resulting in a poor user experience; the synergy between the components is not strong enough, resulting in poor smoking cessation effectiveness; and because essential oil components are easily oxidized, the shelf life is short, affecting the stability and effectiveness of the product; and an unreasonable preparation process can lead to loss of active ingredients and uneven system.

[0005] In summary, current smoking cessation and tobacco control products have four major technical pain points: First, the single route of action (such as oral or topical use only) leads to limited effects, and the success rate of smoking cessation is less than 30%; second, essential oil products have a short shelf life (usually ≤3 months) due to oxidation and deterioration, and the active ingredients are easily volatile; third, the frequency of use is high (4-5 times a day), and user compliance is poor; fourth, the products and usage methods are prone to induce negative feelings or emotions, and consumer acceptance is low, making it difficult to achieve continuous and lasting smoking cessation, and therefore it is impossible to continuously solve problems such as reducing or quitting smoking. Summary of the Invention

[0006] To overcome the above-mentioned shortcomings of the above-mentioned prior art, the present invention provides an acupoint massage essential oil for assisting in smoking control and refreshing the mind, and a preparation method thereof. Based on the "Traditional Chinese Medicine monarch, minister, assistant and envoy + dual absorption pathway" design, through formula optimization, process improvement and acupoint massage synergy, the various components work synergistically to quickly inhibit monoamine oxidase (MAO) activity and increase dopamine levels in the brain, thereby producing pleasure and reducing smoking addiction. At the same time, the essential oil has a mild and aromatic characteristic, which improves user acceptance and simulates and exceeds the pleasurable experience obtained by smoking, so as to achieve the comprehensive goal of "positive pleasurable feeling + rapid onset (within 10 minutes) + long-lasting effect (12 hours) + low frequency of use (1-2 times a day)". By creating a pleasurable experience similar to smoking, it significantly reduces smokers' craving for smoking and boosts their spirits, thereby solving various problems of such existing compound essential oil products.

[0007] To achieve the above object, the technical solution provided by the present invention is: Disclosed is an acupoint massage essential oil for assisting in smoking control and refreshing the mind. The oil is a high-concentration compound essential oil for external use designed based on the monarch-minister-adjuvant-adjuvant compatibility model of traditional Chinese medicine and human acupoints. The oil comprises the following components, measured by mass percentage: 25%-35% of galangal essential oil (a monarch ingredient), 20%-30% of lemon essential oil (a minister ingredient), 10%-15% of peppermint essential oil (a minister ingredient), 3%-5% of coenzyme Q10 (a minister ingredient), 8%-10% of limonene (a minister ingredient), 8%-10% of linalool (a minister ingredient), 2%-4% of methyl cinnamate (a minister ingredient), 15%-20% of jojoba oil (a minister ingredient), and 1%-3% of vanillin (a minister ingredient); and auxiliary components include 0.8% of a natural antioxidant and 1.2% of an aromatic synergist; the natural antioxidant comprises 0.5% of vitamin E and 0.3% of rosemary extract; and the aromatic synergist is rose essential oil.

[0008] The mass percentage of each component in the balanced formula is: high ginger essential oil 30%, lemon essential oil 25%, mint essential oil 12%, coenzyme Q10 4%, limonene 9%, linalool 8%, methyl cinnamate 3%, jojoba oil 16%, vanilla 2%, vitamin E 0.5%, rosemary extract 0.3%, and rose essential oil 1.2%.

[0009] The mass percentage of each component in the high ginger formula is: high ginger essential oil 32%, lemon essential oil 22%, mint essential oil 10%, coenzyme Q10 5%, limonene 8%, linalool 9%, methyl cinnamate 4%, jojoba oil 16%, vanilla 1%, vitamin E 0.5%, rosemary extract 0.3%, and rose essential oil 1.2%.

[0010] The mass percentage of each component in the high mint formula is: high ginger essential oil 25%, lemon essential oil 30%, mint essential oil 15%, coenzyme Q10 3%, limonene 10%, linalool 9%, methyl cinnamate 2%, jojoba oil 17%, vanilla 3%, vitamin E 0.5%, rosemary extract 0.3%, and rose essential oil 1.2%.

[0011] The mass percentage of each component in the high base formula is: high ginger essential oil 32%, lemon essential oil 20%, mint essential oil 13%, coenzyme Q10 4%, limonene 9%, linalool 9%, methyl cinnamate 3%, jojoba oil 20%, vanilla 2%, vitamin E 0.5%, rosemary extract 0.3%, and rose essential oil 1.2%.

[0012] A preparation method of an acupoint massage essential oil for assisting in smoking control and refreshing, comprising the following steps: (1) Raw material pretreatment: filter high ginger essential oil and lemon essential oil through a 0.22 μm organic filter membrane; dissolve coenzyme Q10 with jojoba oil in a 50°C water bath; pre-dissolve rosemary extract with anhydrous ethanol at a mass ratio of 1:5; (2) Low-temperature stepwise mixing: first, add jojoba oil to a stainless steel reaction kettle, set the temperature to 30°C, and the stirring rate to 300 r / min, then add vitamin E and rosemary extract, and stir for 10 minutes until completely dissolved; second, add high ginger essential oil and lemon essential oil in sequence, and stir for 20 minutes; third, add mint essential oil, limonene, linalool, and methyl cinnamate, and stir for 15 minutes; fourth, add dissolved coenzyme Q10 and rose essential oil, and finally add vanilla, and stir for 10 minutes until the system is uniform; (3) Vacuum degassing and sterile treatment: the mixed solution is transferred into a vacuum degassing machine, and is treated at a vacuum degree of -0.08 MPa for 5 minutes; ultrahigh temperature instant sterilization is adopted, and the solution is treated at 135 DEG C for 3 seconds, is quickly cooled to 30 DEG C, and is then naturally cooled to room temperature, to obtain the acupoint massage essential oil for assisting in smoking control and refreshing; (4) Filling and storage: sterile filling is performed by using a brown glass dropper bottle, 5-10 ml per bottle, and the bottle opening is sealed by a film; and the product is stored in the dark, in a cool place (15-25 DEG C), and at a relative humidity of less than or equal to 60%.

[0013] The acupoint massage essential oil for assisting in smoking control and refreshing and the preparation method thereof have at least the following beneficial effects: 1. The present application adopts organic combination of multiple components, is designed based on "TCM monarch, minister and assistant + double absorption path", realizes the comprehensive goal of "positive pleasant feeling + rapid effect (within 10 minutes) + long-acting effect (12 hours) + low frequency of use (1-2 times per day)", and brings the user a pleasant feeling similar to or exceeding that of smoking, significantly reduces the desire of the smoking population for smoking, and boosts the spirit. First, the double absorption path of external use + massage + sniffing is adopted, the absorption rate of the user to the MAO active ingredient is improved, and the success rate of smoking cessation is improved; second, the short storage period of the essential oil product is prolonged, and the volatilization of the effective component is avoided; third, the high frequency of use (2-3 times per day) is reduced, and the user compliance is good; fourth, the product fragrance is mild (without irritating taste), the user is induced to have a positive feeling (pleasure) and avoid a negative feeling (discomfort), the acceptance of the consumer is improved, the continuous and persistent smoking cessation is realized, and the problems of continuous reduction or cessation of the smoking addiction are solved.

[0014] 2、The present application is through the basic theory model of traditional Chinese medicine, adopts multiple component organic combination to form MAO inhibition + aroma regulation + transdermal synergistic mechanism, so that it becomes a massage essential oil for smoking population, through acupoint massage and sniffing method, produces similar beneficial effect to smoking (belongs to nicotine safe alternative therapy), produces a pleasant feeling after smoking, thereby reducing the desire of smoking population for smoking, replacing the sensory experience brought by smoking, and providing a long-acting, sustainable product for reducing the craving for smoking for the smoking population; specifically, a variety of substances inhibiting monoamine oxidase and cholinesterase are combined into a smoke friend refreshing massage essential oil specially used for smoking population, which is a compound essential oil composed of high galangal essential oil and lemon essential oil, through the use of sniffing and acupoint massage, the pleasant experience produced is helpful for the smoking population to solve the adverse reactions and pain of smoking cessation, and the smoking population can obtain similar pleasant feeling to smoking, thereby reducing the frequency of smoking, and gradually achieving the purpose of smoking cessation, providing a product for reducing or quitting the craving for smoking which is willingly accepted by the smoking population, significantly reducing the demand of smoking population for smoking and boosting the spirit.

[0015] 3、The acupoint massage essential oil for assisting in smoking control and refreshing provided by the present application is a new product considering various factors for quitting smoking, through mutual cooperation of sniffing, acupoint massage and transdermal absorption, the smoking experience substitution can be quickly achieved (within 10 minutes) when the user has the desire to smoke; the long-acting effect (about 12 hours) can be achieved by combining acupoint massage and transdermal absorption, thereby reducing the use frequency (1-2 times per day); the product is sealed in a bottle, and the user can perform acupoint massage operation on himself after simple training, which is convenient to carry and use; the fragrance after use is pleasant, can boost the spirit of the user and does not affect the surrounding population, and has good integration with the environment and scene.

[0016] 4、According to the compatibility theory of traditional Chinese medicine, the components are selected in a small amount to simplify the preparation process and reduce the cost of raw materials; combined with the improvement of the preparation method, the synergistic effect between the components of the compound essential oil is enhanced, on the one hand, the compound essential oil can be pleasant and effectively assist in smoking cessation, on the other hand, the shelf life of the compound essential oil can be more than 6 months, so as to guarantee the quality and stability of the product, facilitate batch production and long-term and continuous use of the user, and provide a long-acting, low-cost and sustainable product for reducing the craving for smoking for the smoking population.

[0017] 5、The acupoint massage essential oil for assisting in smoking control and refreshing provided by the present application is sealed in a bottle, and can be used immediately after opening, which is convenient to use; the absorption after use is complete and there is no residue, which is clean and safe; the requirements for acupoint positioning (the coating area is large) and massage method (various methods can be used) are not high, and there is no difficulty for ordinary people and professionals to use, without the need for special training, which is conducive to wide application and promotion.

[0018] 6. The method for preparing the acupoint massage essential oil for assisting smoking control and refreshing the mind, provided herein, ensures product quality and stability through steps such as raw material pretreatment, low-temperature step-by-step mixing, vacuum degassing and aseptic processing, filling, and storage. This method ensures the full dissolution of the components, particularly salicylic acid, ethyl vanillin, and ethyl vanillin, while also reducing the loss of essential oil active substances (including aromatic components) from volatilization during the preparation process. Thirdly, the method provides a finished compound essential oil with a high concentration of active ingredients. Once sealed and bottled, it is ready for use without further dilution, making it convenient for ordinary consumers to purchase, store, and use. DETAILED DESCRIPTION

[0019] The technical solutions of the present invention are described in detail below through examples.

[0020] Basic Example The acupoint massage essential oil provided in an embodiment of the present invention is a high-concentration compound essential oil for external use designed based on the monarch-minister-adjuvant-guiding compatibility model of traditional Chinese medicine and human acupoints. The oil comprises the following components, by mass percentage: 25%-35% of galangal essential oil, 20%-30% of lemon essential oil, 10%-15% of peppermint essential oil, 3%-5% of coenzyme Q10, 8%-10% of limonene, 8%-10% of linalool, 2%-4% of methyl cinnamate, 15%-20% of jojoba oil, 1%-3% of vanillin, and 0.8% of a natural antioxidant and 1.2% of an aromatic synergist as auxiliary components; the natural antioxidant comprises 0.5% of vitamin E and 0.3% of rosemary extract; and the aromatic synergist is rose essential oil.

[0021] The acupoint massage essential oil for assisting in smoking control and refreshing the mind is applied externally and massages the human acupoints including Neiguan, Hegu, Zusanli, Renzhong, ear, Fenglong and Shenmen. A single acupoint massage lasting 2-3 minutes is effective.

[0022] A method for preparing an acupoint massage essential oil for assisting in smoking control and refreshing the mind, comprising the following steps: (1) Raw material pretreatment: Filter galangal essential oil and lemon essential oil through a 0.22 μm organic filter membrane; dissolve coenzyme Q10 in jojoba oil in a 50°C water bath; pre-dissolve rosemary extract in anhydrous ethanol at a mass ratio of 1:5; (2) Low-temperature step mixing: Step 1: Add jojoba oil to a stainless steel reactor, set the temperature to 30°C, stir at a rate of 300 r / min, add vitamin E and rosemary extract, and stir for 10 minutes until completely dissolved; Step 2: Add galangal essential oil and lemon essential oil in sequence, and stir for 20 minutes; Step 3: Add peppermint essential oil, limonene, linalool, and methyl cinnamate, and stir for 15 minutes; Step 4: Add dissolved coenzyme Q10 and rose essential oil, and finally add vanillin, and stir for 10 minutes until the system is homogeneous; (3) Vacuum degassing and aseptic treatment: The mixed solution was transferred to a vacuum degasser and treated at a vacuum degree of -0.08 MPa for 5 minutes; ultra-high temperature instantaneous sterilization was performed at 135°C for 3 seconds, rapidly cooled to 30°C, and then naturally cooled to room temperature to obtain acupoint massage essential oil for assisting smoking control and refreshing. (4) Filling and storage: Aseptically fill in brown glass dropper bottles, 5-10 ml per bottle, and seal the bottle mouth with sealing film; store in a dark, cool place (15-25℃) with relative humidity ≤60%.

[0023] The mass percentages and core functions of the components of the acupoint massage essential oil product for assisting smoking control and refreshing the mind in this embodiment are shown in Table 1 below.

[0024] Table 1

[0025] The embodiment of the present invention solves the following technical problems through the coordinated improvement of the recipe 1 process: (1) Resolving the contradiction between the synergistic effect of each component and the odor acceptance. Through a reasonable component ratio, especially the addition of rose essential oil as an aromatic synergist, a "floral and fruity aroma complex system" is formed with the original aromatic components. While enhancing the synergistic effect, the odor is made milder and more pleasant. This overcomes the shortcomings of similar products that use components such as turmeric essential oil, which result in a strong irritating odor. The acceptance score increased from 95 points to 98 points.

[0026] (2) Solve the contradiction between active ingredient retention and preparation process. A low-temperature step mixing process is adopted. The mixing temperature of 30°C is far lower than the thermal stability threshold of active ingredients such as galangin and D-limonene, ensuring that the retention rate of MAO inhibitory active ingredients reaches 98%, avoiding the loss of active ingredients caused by high temperature.

[0027] (3) Solve the contradiction between the easy oxidation and deterioration of high-concentration essential oils and the need for a long shelf life. By adding natural antioxidants composed of vitamin E and rosemary extract, combined with low-temperature mixing, vacuum degassing, and light-proof packaging, the degradation rate of the active ingredients of the compound essential oil is reduced to less than 10% within 6 months, and the shelf life can be extended to more than 6 months.

[0028] The embodiment of the present application mainly realizes the following technical effects: (1) The synergistic effect is significantly enhanced. The "triple-MAO inhibition network" formed by the combination of high-palmarosa-phenol in high-palmarosa-essential oil, D-limonene and sabinene in lemon essential oil makes the MAO activity decrease by 82%, which is much higher than the 58% of single high-palmarosa-phenol. The "aroma-neuroregulation axis" formed by the combination of linalool and vanillin can improve the emotional relaxation effect by about 40% when sniffing.

[0029] (2) The effect of smoking cessation is significant. The compound essential oil can effectively reduce the frequency of smoking impulse and reduce the score of withdrawal symptoms through acupoint massage and sniffing. The clinical trial data from a third party shows that the short-term smoking cessation success rate is improved by about 25% compared with existing products, and the long-term smoking cessation success rate is improved by about 20%.

[0030] (3) The product has good stability. Accelerated experiments show that the system is still homogeneous and single-phase after 6 months, the MAO inhibition rate only decreases by 5%, and the dopamine transporter binding rate is maintained at more than 65%, which is much better than existing products.

[0031] The present application is based on the comprehensive design of "TCM monarch, minister, and auxiliary + double absorption path + pleasant experience + self-use", which realizes the comprehensive goal of "fast-acting (within 10 minutes) + long-acting (12 hours) + low-frequency use (1-2 times a day) + pleasant experience + good social environmental integration" through the synergy of formula optimization, process innovation, and user personal use at any time and anywhere. The user's experience, accessibility, compliance, and initiative are good, and they are willing to actively use and continuously use.

[0032] The following will be described in detail with multiple specific embodiment formulas.

[0033] Embodiments 1-4 The acupoint massage essential oil for assisting smoking control and refreshing and the preparation method thereof provided by embodiments 1-4 of the present application are specific selection and optimization based on the basic embodiment, and the difference lies in that the mass percentage of the components of each embodiment is specifically selected as shown in the following table 2.

[0034] Table 2

[0035] The acupoint massage essential oil for assisting smoking control and refreshing provided by embodiments 1-4 has the following monarch-minister-auxiliary compatibility logic: 1. Example 1 (Balanced type): All components take intermediate values, suitable for most quitters. 30% Galangal essential oil ensures basic MAO inhibition rate (75%), 25% lemon essential oil and 9% limonene synergistically enhance the effect, 16% jojoba oil achieves 6-8 hours of sustained release, the comprehensive onset time is 10 minutes, and the sustained effect is 10 hours, which meets the conventional smoking cessation needs.

[0036] 2. Example 2 (High-king drug type): 35% Galangal essential oil increases the MAO inhibition rate to 82%, combined with 5% coenzyme Q10 to enhance antioxidant stability, suitable for people with long smoking age (≥10 years) and heavy smoking habit (≥20 cigarettes per day). 15% jojoba oil reduces the base ratio to ensure high concentration of active ingredients, while 1% vanillin avoids excessive pungent odor.

[0037] 3. Example 3 (High-menthol type): 15% menthol essential oil increases the transdermal rate by 5 times, combined with the strong aromatic stimulation of 30% lemon essential oil, the onset time is shortened to 6-8 minutes, suitable for people with high frequency of sudden smoking habit (such as those under high work pressure). 10% linalool and 3% vanillin balance the cooling sensation of menthol, avoiding excessive irritation.

[0038] 4. Example 4 (High base type): 20% jojoba oil forms a long-acting sustained-release system, the sustained effect time is extended to 12-14 hours, combined with the medium-intensity inhibition of 32% galangal essential oil, suitable for people who need to reduce the use frequency (once a day) (such as the elderly). The low proportion of 20% lemon essential oil reduces the odor intensity, improving long-term use tolerance.

[0039] The auxiliary smoking control and refreshing acupoint massage essential oil formula provided in Examples 1-4 has reasonable composition and functional synergy, including: 1. Dynamic proportion balance: When the proportion of the king drug (galangal) increases (such as Example 2), the antioxidant component (coenzyme Q10) in the auxiliary drug is simultaneously increased to avoid oxidation of high-concentration active ingredients; when the proportion of the minister drug (lemon essential oil) decreases (such as Example 4), vanillin is maintained at an intermediate value (2%) to ensure odor coordination.

[0040] 2. Scene adaptability: The four formulas cover four scenes of “regular smoking cessation”, “heavy smoking habit”, “sudden smoking habit”, and “low frequency use”, respectively, achieving functional differentiation by adjusting the proportion of king, minister, and auxiliary drugs, and all conform to the core design of “transdermal + olfactory” dual absorption path.

[0041] 3. Stability Verification: The vitamin E and rosemary extract content in all formulas is fixed at 0.8%. Accelerated testing has shown that the active ingredient retention rate is ≥90% after 6 months, meeting storage requirements. The jojoba oil content is between 15% and 20% to ensure system uniformity (no stratification).

[0042] The acupoint massage essential oil formulas provided in Examples 1-4 for assisting in smoking control and refreshing the mind can provide users with a smoking-like experience by sniffing or applying to acupoints for massage, producing a similar feeling of pleasure to that after smoking, thereby alleviating smokers' cravings and boosting their spirits. The main synergistic effects between the various components include: 1. Synergistic inhibition system: Galangin (monarch drug), D-limonene (minister drug), and limonene (adjuvant drug) form a "triple MAO inhibition network". In vitro experiments show that the MAO-A / B inhibition rates reach 82.3% and 79.5%, respectively, which are about 40% higher than that of single galangal essential oil (58.7%).

[0043] 2. Double antioxidant protection: Vitamin E (free radical scavenging) and rosemary extract (metal ion chelation) work together to ensure that the active ingredient retention rate reaches 90% after 6 months (traditional formulas only retain 65%).

[0044] 3. Aromatic complementary network: Citral (fresh) + rose essential oil (floral) + vanillin (sweet). GC-O analysis showed a 20% increase in pleasant odor activity value (OAV) and a user acceptance score of 98 points.

[0045] A method for preparing an acupoint massage essential oil for assisting in smoking control and refreshing the mind is substantially the same as the basic embodiment, except that it further comprises the following contents: (1) Raw material pretreatment stage (11) Galangal essential oil and lemon essential oil were filtered through a 0.22 μm organic filter membrane to remove plant residues; (12) Dissolve coenzyme Q10 in 50°C jojoba oil (the solubility is increased to 95%) to avoid crystallization; (13) Rosemary extract was pre-dissolved in anhydrous ethanol (1:5 mass ratio) to enhance dispersibility.

[0046] (2) Low temperature step mixing stage (21) In a 30°C constant temperature reactor, add the ingredients in the order of “adjuvant drug → monarch drug → minister drug → adjuvant drug → auxiliary component” and stir at 300 r / min for 40 minutes to ensure the homogeneity of the system (to avoid high temperature destruction of the active ingredients).

[0047] (3) Vacuum degassing and sterilization stage -0.08 MPa vacuum treatment for 5 minutes to remove bubbles (prevent oxidation acceleration); 135℃ ultra-high temperature instant sterilization (3 seconds), rapid cooling to 30℃ (microbial kill rate 99.9%).

[0048] (4) Packaging and storage stage Packaging in brown glass dropper bottles (10ml / bottle) in the dark, stored at 15-25℃ and humidity ≤60%, shelf life 6 months.

[0049] The advantages of the preparation method provided by the embodiment are: 1. Low-temperature mixing retains 98% of the retention rate of thermosensitive components such as galangin and linalool (only 82% at 60°C mixing); 2. Step-by-step dissolution technique avoids coenzyme Q10 precipitation, and 6-month accelerated experiment shows that the system has no stratification.

[0050] The use scheme of the acupoint massage essential oil for assisting in smoking control and refreshing provided by the embodiment of the application (combined with traditional Chinese medicine acupoint theory) includes the following contents: (I) Core acupoints and operation specification reference Table 3, users can operate or operate each other after simple training.

[0051] Table 3

[0052] (II) Double absorption path cooperative operation explanation 1. Transdermal absorption optimization Acupoint pretreatment: 40℃ warm water wiping for 30 seconds, the water content of the stratum corneum from 15% to 25%, the transdermal rate is increased by 2 times; Massage timing: morning 7:00 (Neiguan + Heigu), evening 21:00 (Zusanli), combined with "finger abdominal spiral pressing method" (60 times / minute, lasting 2 minutes).

[0053] 2. Smell absorption enhancement Combined with a specially designed nasal plug type smell device (elastic foam nasal plug, containing 2ml essential oil + 0.1g β-cyclodextrin inclusion compound), deep breathing for 3 seconds→ holding breath for 2 seconds→ exhale for 5 seconds, repeat 3 times; Cooperative timing: smell for 1 minute first (activate the center)→ massage (bioavailability increased by 25%), smell once alone when a sudden smoking urge can quickly suppress the impulse.

[0054] (III) Use frequency optimization (see Table 4) Table 4

[0055] The mechanism of action (multi-dimensional collaborative network) of the acupoint massage essential oil for assisting in smoking control and refreshing the mind in the embodiment of the present invention includes: (I) MAO inhibition and dopamine regulatory pathways 1. Decomposition inhibition: Galangin competitively binds to the MAO active site, preventing dopamine decomposition; D-limonene and limonene assist in enhancing the inhibitory effect, reducing the dopamine metabolic rate by 65%.

[0056] 2. Release promotion: Citral (lemon essential oil) triggers the limbic system through the olfactory nerve, prompting the release of dopamine vesicles, and the concentration increases by 15% within 10 minutes.

[0057] 3. Reuptake blockade: Linalool inhibits the dopamine transporter (DAT), prolonging the action time of dopamine in the synaptic cleft and maintaining a sense of excitement.

[0058] (2) Aromatic neuromodulatory mechanism The sweet aroma components of citronellol and vanillin in rose essential oil are transmitted to the amygdala through the olfactory bulb, inhibiting the secretion of anxiety-related norepinephrine and reducing withdrawal anxiety scores by 45% (clinical reference data).

[0059] (3) Principle of acupoint transdermal enhancement 1. Menthol changes the lipid arrangement of the stratum corneum, increasing the transdermal rate of galangin by 3-5 times; 2. Massaging the Neiguan acupoint activates the pericardium meridian qi, and the drug is transmitted to the central nervous system through the meridians. The concentration in the brain is three times that of non-acupoint application. 3. Jojoba oil forms a "drug reservoir", achieving a biphasic kinetic of "2 hours of rapid release + 10 hours of slow release".

[0060] The effectiveness of the acupoint massage essential oil for assisting in smoking control and refreshing the mind according to the embodiment of the present invention (main experimental data and clinical cases) is shown in the following table: (1) Key experimental data (Table 5) Table 5

[0061] (2) Clinical Cases Case 1: Middle-aged men quit smoking Mr. Zhang, 45 years old (20 years of smoking, an average of 20 cigarettes per day), reduced his smoking from 15 cigarettes per day to 3 cigarettes per day after using the product of Example 1 (balanced) for one month, and his withdrawal irritability disappeared. After three months, he completely quit smoking, his cough symptoms were relieved, and lung function tests showed that his FEV1 increased by 12%.

[0062] Case 2: Elderly smoker quits smoking Mr. Li, 62 years old (35 years of smoking, chronic bronchitis), uses the morning and evening acupoint massage + sniffing scheme, uses the product of Example 2 (high Jun medicine type), 2 months later, the amount of smoking is reduced by 70%, the amount of sputum is reduced, and the quality of sleep at night is improved (the sleep time is shortened from 60 minutes to 20 minutes).

[0063] Case three: high frequency of smoking addiction control case Mr. Wang, 28 years old (5 years of smoking, 10 cigarettes per day, significant smoking addiction during work breaks), through the "acupoint massage + 1 sniffing" scheme, uses the product of Example 3 (high mint type) 2 weeks later, the smoking impulse during work period is reduced from 2 times per hour to 0.5 times, and the concentration is improved (the score of digital memory test is increased by 25%).

[0064] (Three) Product advantages and technical breakthroughs Conflict resolution: balance the speed of onset and duration through "fast release + slow release system", break through the industry bottleneck of "fast-acting short-acting".

[0065] Integration of traditional Chinese and Western medicine: combination of aromatherapy, acupoint meridian theory and transdermal absorption technology, target specificity is increased by 40%, and systemic side effects are reduced.

[0066] User experience optimization: standardized operation (5 minutes / time) + low frequency of use (1-2 times / day), compliance score reaches 92 points, which is much higher than the 75 points of traditional products.

[0067] The application provides the applicable population and precautions of the acupoint massage essential oil, which include: 1. Applicable population: 18-65 year-old smokers with smoking age ≥1 year, especially those who have resistance to drug smoking cessation and strong dependence psychology.

[0068] 2. Contraindications: pregnant women, infants and children, and those allergic to citrus / zingiberaceae are prohibited; it is prohibited to apply to damaged skin.

[0069] 3. Storage requirements: store in a cool and dark place, and use it up within 3 months after opening to ensure activity.

[0070] The acupoint massage essential oils and preparation methods for smoking control and mental refreshment provided in the aforementioned embodiments of the present invention achieve the combined goals of "enhanced effectiveness, optimized experience, and controlled costs" through comprehensive innovation across the entire process from formulation to processing to usage, providing a new product integrating traditional Chinese and Western medicine for smoking cessation aids. The active ingredients of the massage essential oils enter the human body through a combination of inhalation and acupoint massage, rapidly inhibiting monoamine oxidase activity, enabling smokers to experience the beneficial effects and pleasure of smoking, suppressing their cravings and alleviating their urge to smoke. For smokers quitting, the oils can help alleviate the adverse reactions and pain of cravings, gradually reducing their actual smoking frequency and ultimately achieving the goal of quitting. With active and sustained user experience, the combination of inhalation and acupoint massage can quickly produce a smoking-like experience, generating a pleasurable sensation, thereby alleviating smokers' cravings and boosting their spirits, helping them gradually reduce their cravings and boost their spirits. This product can be used as a nicotine substitute, providing a series of essential oil products for both medical and health care use. Through external application + acupoint massage + transdermal absorption + oral and nasal inhalation, it has a mild and pleasant fragrance, is easy to carry and use at any time, improves user experience and psychological feelings during use, increases their subjective enthusiasm and initiative, and reverses users' resistance to smoking cessation products. It can solve problems such as low consumer acceptance and users' unwillingness to use it for a long time, which leads to persistent smoking addiction, repeated quitting, and poor results.

[0071] It should be noted that within the scope of the components, proportions, and process parameters described in the present invention, the compound essential oils obtained by specifically selecting commercially available products, proportions, and parameters can achieve the technical effects described in the present invention. Therefore, the present invention will not list them one by one.

[0072] In addition, the present invention provides a compound acupoint massage essential oil product that helps smokers replace smoking. It cannot replace other medicines. Due to individual differences in the human body and the different smoking years of smokers, the reactions and effects of the product will also be different. Users need to choose a suitable product according to their actual situation. Users who do not see any effect from the compound acupoint massage essential oil applied for by the present invention should seek help from experts or doctors.

[0073] The products described above are merely exemplary embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An acupoint massage essential oil for assisting in smoking control and refreshing, characterized in that: It is a high-concentration compound essential oil for external use designed based on the monarch-minister-adjuvant-adjuvant compatibility model of traditional Chinese medicine and human acupuncture points. It includes the following components by mass percentage: monarch drug galangal essential oil 25%-35%, assistant drug lemon essential oil 20%-30%, assistant drug peppermint essential oil 10%-15%, assistant drug coenzyme Q10 3%-5%, assistant drug limonene 8%-10%, assistant drug linalool 8%-10%, assistant drug methyl cinnamate 2%-4%, assistant drug jojoba oil 15%-20%, and assistant drug vanillin 1%-3%.

2. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in claim 1, characterized in that: The invention also comprises auxiliary components of natural antioxidant 0.8% and aromatic synergist 1.2%; the natural antioxidant is composed of vitamin E 0.5% and rosemary extract 0.3%; and the aromatic synergist is rose essential oil.

3. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in claim 2, characterized in that: In its balanced formula, the mass percentage of each component is: 30% galangal essential oil, 25% lemon essential oil, 12% peppermint essential oil, 4% coenzyme Q10, 9% limonene, 8% linalool, 3% methyl cinnamate, 16% jojoba oil, 2% vanillin, 0.5% vitamin E, 0.3% rosemary extract, and 1.2% rose essential oil.

4. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in claim 2, characterized in that: The mass percentages of the components in its Gaojun medicinal formula are: 32% galangal essential oil, 22% lemon essential oil, 10% peppermint essential oil, 5% coenzyme Q10, 8% limonene, 9% linalool, 4% methyl cinnamate, 165% jojoba oil, 1% vanillin, 0.5% vitamin E, 0.3% rosemary extract, and 1.2% rose essential oil.

5. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in claim 2, characterized in that: In its high-mint formula, the mass percentage of each component is: 25% galangal essential oil, 30% lemon essential oil, 15% peppermint essential oil, 3% coenzyme Q10, 10% limonene, 9% linalool, 2% methyl cinnamate, 17% jojoba oil, 3% vanillin, 0.5% vitamin E, 0.3% rosemary extract, and 1.2% rose essential oil.

6. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in claim 2, characterized in that: In its high-base formula, the mass percentage of each component is: galangal essential oil 32%, lemon essential oil 20%, peppermint essential oil 13%, coenzyme Q10 4%, limonene 9%, linalool 9%, methyl cinnamate 3%, jojoba oil 20%, vanillin 2%, vitamin E 0.5%, rosemary extract 0.3%, and rose essential oil 1.2%.

7. The acupoint massage essential oil for assisting in smoking control and refreshing the mind as claimed in any one of claims 1 to 6, characterized in that: The human acupuncture points that are coated and massaged externally include: Neiguan, Hegu, Zusanli, Renzhong, ear, Fenglong and Shenmen. A single massage of an acupuncture point lasts for 2-3 minutes.

8. A method for preparing an acupoint massage essential oil for assisting in smoking control and refreshing the mind, characterized in that: The method for preparing the acupoint massage essential oil for assisting smoking control and refreshing the mind as claimed in any one of claims 1 to 7 comprises the following steps: (1) Raw material pretreatment: Filter galangal essential oil and lemon essential oil through a 0.22 μm organic filter membrane; dissolve coenzyme Q10 in jojoba oil in a 50°C water bath; pre-dissolve rosemary extract in anhydrous ethanol at a mass ratio of 1:5; (2) Low-temperature step mixing: Step 1: Add jojoba oil to a stainless steel reactor, set the temperature to 30°C, stir at a rate of 300 r / min, add vitamin E and rosemary extract, and stir for 10 minutes until completely dissolved; Step 2: Add galangal essential oil and lemon essential oil in sequence, and stir for 20 minutes; Step 3: Add peppermint essential oil, limonene, linalool, and methyl cinnamate, and stir for 15 minutes; Step 4: Add dissolved coenzyme Q10 and rose essential oil, and finally add vanillin, and stir for 10 minutes until the system is homogeneous; (3) Vacuum degassing and aseptic treatment: The mixed liquid is transferred to a vacuum degasser and treated at a vacuum degree of -0.08MPa for 5 minutes; ultra-high temperature instantaneous sterilization is used, treated at 135℃ for 3 seconds, quickly cooled to 30℃, and then naturally cooled to room temperature to obtain acupoint massage essential oil that assists in smoking control and refreshing.

9. The preparation method according to claim 8, characterized in that It also includes the following steps: (4) Filling and storage: Aseptically fill in brown glass dropper bottles, 5-10 ml per bottle, and seal the bottle mouth with sealing film; store in a dark, cool place (15-25℃) with relative humidity ≤60%.

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