High-elasticity medical rubber gloves and preparation method thereof
By combining hydrogenated nitrile rubber, isoprene rubber and nanocellulose, combined with homemade antibacterial agents, highly elastic medical rubber gloves are prepared, which solves the shortcomings of existing medical rubber gloves in antibacterial, elasticity and mechanical properties, and achieves more efficient protective effects.
Patent Information
- Application Number
- CN202511191913.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-25
- Publication Date
- 2025-10-10
AI Technical Summary
Existing medical rubber gloves have deficiencies in antibacterial properties, elasticity and mechanical properties, and are unable to meet the efficient protection needs of modern medical environments.
Hydrogenated nitrile rubber and isoprene rubber were used to form a complementary network, nanocellulose and a homemade antibacterial agent containing quaternary ammonium salt of pyridine and coumarin were added, and high-elasticity medical rubber gloves were prepared through a segmented vulcanization process.
The elasticity and antibacterial properties of the gloves are improved, the mechanical properties are enhanced, and the protection needs of modern medical environments are met.
Smart Images
Figure SMS_1 
Figure SMS_2
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of rubber gloves, in particular, it relates to a high-elasticity medical rubber glove and a preparation method thereof. BACKGROUND
[0002] Medical rubber gloves, as indispensable protective equipment in the medical field, play a crucial role in preventing cross-infection of pathogenic bacteria between doctors and patients and ensuring the safety of medical operations. Although traditional natural rubber gloves have good elasticity and fit, they have many technical bottlenecks in long-term use. First, the allergenic proteins in natural rubber are difficult to completely remove, and even after multiple washing and enzyme treatment, they may still cause allergic reactions such as contact dermatitis. According to statistics, about 8%-12% of medical staff have occupational health problems due to this. Second, the elastic recovery rate of existing gloves is generally less than 92%, and they are prone to permanent deformation after repeated stretching, especially at the frequently bending parts such as finger joints. The thickness reduction rate can reach more than 15% after 2 hours of use, which seriously affects the protective effect.
[0003] As a main substitute product, nitrile rubber gloves can avoid allergic risks and have better chemical resistance, but the traditional products have medium elasticity and are prone to hardening after long-term stretching, and their fit is inferior to natural rubber, which may affect flexibility, especially in complex medical operations. Moreover, in the modern medical environment, the spread of pathogens is a serious challenge. The incidence of cross-infection in hospitals is high, and hand contact is one of the main transmission routes. Although wearing gloves can provide a certain barrier, if the surface of the gloves is contaminated and not replaced in time, or if improper operation occurs during removal, it may lead to the spread of pathogens. In addition, in some special scenarios such as intensive care units (ICU), operating rooms, or infectious disease prevention areas, medical staff need to frequently contact patient body fluids, blood, and other potential sources of infection. In this case, the antibacterial properties of ordinary nitrile gloves may not fully meet the high-efficiency protection needs. Therefore, it is urgent to solve the above problems to meet the higher demands in the technical field of rubber gloves. SUMMARY
[0004] The present application provides a high-elasticity medical rubber glove and a preparation method thereof, which solves the problem of poor antibacterial property of medical rubber gloves in related technologies.
[0005] The technical scheme of the present application is as follows: The present application provides a high-elasticity medical rubber glove, which comprises the following raw materials by weight: 60-70 parts of hydrogenated nitrile rubber, 30-40 parts of isoprene rubber, 6-10 parts of nanocellulose, 20-25 parts of ethanol, 1.5-2.5 parts of vulcanizing agent, 0.8-1.6 parts of antioxidant, and 2-6 parts of bacteriostatic agent.
[0006] As a further technical solution, the vulcanizing agent is a compound of dicumyl peroxide and triallyl isocyanurate in a mass ratio of 2:3.
[0007] As a further technical solution, the antioxidant is one of antioxidant 1010, antioxidant 168 and antioxidant 1076.
[0008] As a further technical solution, the bacteriostatic agent is prepared by the following steps: A1, adding 2, 6-dichloropyridine, 7-hydroxycoumarin and chloroform in a dry three-necked flask, stirring uniformly at room temperature, mixing sodium hydroxide with deionized water, adding into the flask through a constant pressure dropping funnel, after the addition is completed, heating to 65-70 DEG C, and refluxing at the temperature for 5-6h, after the reaction is completed, post-treatment, obtaining the primary product; A2, adding the primary product, bromobutane and chloroform in a dry three-necked flask, stirring uniformly at room temperature, heating to 70-75 DEG C for condensation refluxing, and reacting at the temperature for 10-12h, after the reaction is completed, post-treatment, obtaining the bacteriostatic agent.
[0009] As a further technical solution, the ratio of the amounts of 2, 6-dichloropyridine, 7-hydroxycoumarin, chloroform, sodium hydroxide and deionized water in step A1 is 14.6g:33.5-37.1g:120mL:8.5-9.3g:30mL.
[0010] As a further technical solution, the ratio of the amounts of the primary product, bromobutane and chloroform in step A2 is 39.9g:17.1-18.3g:120mL.
[0011] The reaction formula for preparing the bacteriostatic agent is as follows:
[0012] In the process of preparing the bacteriostatic agent, the molar ratio of 6-dichloropyridine and 7-hydroxycoumarin in step A1 needs to be strictly controlled to be close to 1:2, and 7-hydroxycoumarin is in excess, so as to ensure the reaction to be complete and reduce side reactions; the bromobutane in step A2 also needs to be in excess, so as to ensure the reaction to be complete.
[0013] As can be seen from the above reaction formula, the bacteriostatic agent prepared by the application contains two antibacterial components, pyridine quaternary ammonium salt and coumarin, wherein the pyridine quaternary ammonium salt has a strong positive charge, and the bacterial cell membrane (such as a phospholipid bilayer) and the virus envelope are generally negatively charged; through electrostatic action, the pyridine quaternary ammonium salt is quickly adsorbed to the surface of microorganisms, destroys the stability of the membrane structure, and the charge of the pyridine quaternary ammonium salt is stronger than that of ordinary quaternary ammonium salt, and the antibacterial property is better; the coumarin compound can effectively inhibit the growth of bacteria or fungi and reduce bacterial drug resistance, can play a synergistic effect with the pyridine quaternary ammonium salt, and greatly enhance the antibacterial property of the base.
[0014] The application further provides a preparation method of the high-elasticity medical rubber glove. B1, mixing hydrogenated nitrile rubber and isoprene rubber in a mixer to ensure that the molecular chains of the two rubbers are fully entangled to obtain a uniform blended rubber; B2, mixing nanocellulose and ethanol in a high-speed disperser, and obtaining a stable suspension after ultrasonic treatment to avoid the influence of powder agglomeration on mechanical properties; B3, sequentially adding the blended rubber, a vulcanizing agent, an antioxidant and a bacteriostatic agent to an open mill, slowly adding the suspension after thin passing 6-8 times at 60-70 DEG C, and mixing until the ethanol is completely volatilized to obtain a uniform rubber compound; B4, preheating a preprocessed mold, then immersing the mold in the rubber compound to perform rubber dipping, drying after the rubber dipping is completed, and performing two-stage vulcanization to obtain the high-elasticity medical rubber glove.
[0015] As a further technical solution, the mixing temperature in step B1 is 80-90 DEG C, and the mixing time is 10-20 min.
[0016] As a further technical solution, the ultrasonic treatment time in step B2 is 30-60 min.
[0017] As a further technical solution, the preheating temperature in step B4 is 60-70 DEG C.
[0018] As a further technical solution, the rubber dipping time in step B4 is 10-15 s.
[0019] As a further technical solution, the drying temperature in step B4 is 70-80 DEG C, and the drying time is 5-10 min.
[0020] As a further technical solution, the first-stage vulcanization temperature in the two-stage vulcanization in step B4 is 150-160 DEG C, and the first-stage vulcanization time is 3-5 min; the second-stage vulcanization temperature is 170-180 DEG C, and the second-stage vulcanization time is 5-10 min.
[0021] As a further technical solution, the preprocessed mold is prepared by the following steps: After the glove ceramic mold is cleaned with ion water, it is immersed in a release agent solution containing zinc stearate, taken out after soaking for 10-20s, and dried at 60-70 DEG C to obtain a pretreated mold.
[0022] The working principle and beneficial effects of the present application are: 1. The rubber matrix of the gloves prepared by the present application is hydrogenated nitrile rubber, which can form a complementary network with isoprene rubber, thereby improving the elasticity of the gloves. 2. The addition of nanocellulose in the gloves prepared by the present application can improve the mechanical properties of the gloves. 3. The gloves prepared by the present application add a self-made bacteriostatic agent, which contains two antibacterial components in the molecule, can play a synergistic effect, and greatly enhance the antibacterial properties of the gloves. 4. The preparation process of the present application adopts segmented vulcanization, which can avoid the hardness rise caused by excessive crosslinking. In summary, the gloves prepared by the present application have elasticity, antibacterial properties and mechanical properties, and have important application value in the field of rubber gloves. DETAILED DESCRIPTION
[0023] The technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are involved in the scope of protection of the present application.
[0024] In the following examples and comparative examples: The hydrogenated nitrile rubber is purchased from Shanghai Zannan Science and Technology Co., Ltd., and the brand is ZN35056; the isoprene rubber is purchased from Japan Ruifeng, and the model is IR2200; the particle size of the nanocellulose is 20-50 nm.
[0025] Example 1 Preparation of bacteriostatic agent: A1, add 14.6g 2,6-dichloropyridine, 33.5g 7-hydroxycoumarin and 120mL chloroform in a dry three-necked flask, stir uniformly at room temperature, then mix 8.5g sodium hydroxide with 30mL deionized water, add to the flask through a constant pressure dropping funnel, after the addition is completed, heat to 65 DEG C, and reflux at this temperature for 5h, after the reaction is completed, separate the liquid, wash with deionized water for 3 times, dry the organic phase with anhydrous sodium sulfate, filter, and remove the solvent by rotary evaporation under reduced pressure to obtain the initial product; A2, in a dry three-necked flask, 39.9 g of the initial product, 17.1 g of bromobutane and 120 mL of chloroform were added, stirred uniformly at room temperature, heated to 70 DEG C for condensation reflux, and reacted at this temperature for 10 h, the reaction was completed, the reaction was quenched with excess methanol, filtered, and the bacteriostatic agent was obtained; Prepare the pretreated mold: After the glove ceramic mold was washed with ionized water, it was immersed in a release agent solution containing zinc stearate (5% by mass fraction), soaked for 10 s, and dried at 60 DEG C to obtain a pretreated mold; A method for preparing a high-elasticity medical rubber glove, comprising the following steps: B1, 70 parts of hydrogenated nitrile rubber and 30 parts of isoprene rubber were mixed in a mixer at 80 DEG C for 10 min to ensure that the molecular chains of the two rubbers were fully entangled, and a uniform blended rubber was obtained; B2, in a high-speed disperser, 6 parts of nanocellulose were mixed with 20 parts of ethanol, and after ultrasonic treatment for 30 min, a stable suspension was obtained to avoid the influence of powder agglomeration on mechanical properties; B3, the blended rubber, 1.5 parts of a curing agent (0.6 parts of dicumyl peroxide and 0.9 parts of triallyl isocyanurate), 0.8 parts of antioxidant 168 and 2 parts of bacteriostatic agent were sequentially added to an open mill, and after thin passing 6 times at 60 DEG C, the suspension was slowly added, and the rubber compound was mixed until the ethanol was completely volatilized; B4, the pretreated mold was preheated to 60 DEG C, then immersed in the rubber compound for 10 s, and after the dipping was completed, it was dried at 70 DEG C for 5 min, then first-stage vulcanization was carried out at 150 DEG C for 3 min, and then second-stage vulcanization was carried out at 170 DEG C for 5 min, and after the vulcanization was completed, a high-elasticity medical rubber glove was obtained.
[0026] Example 2 Preparation of bacteriostatic agent: A1, in a dry three-necked flask, 14.6 g of 2,6-dichloropyridine, 37.1 g of 7-hydroxycoumarin and 120 mL of chloroform were added, stirred uniformly at room temperature, then 9.3 g of sodium hydroxide was mixed with 30 mL of deionized water, and added to the flask through a constant pressure dropping funnel, after the addition was completed, heated to 70 DEG C, and refluxed at this temperature for 6 h, the reaction was completed, separated, washed with deionized water 3 times, the organic phase was dried with anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation under reduced pressure to obtain the initial product; A2, in a dry three-necked flask, 39.9 g of the initial product, 18.3 g of bromobutane and 120 mL of chloroform were added, stirred uniformly at room temperature, heated to 75 DEG C for condensation reflux, and reacted at this temperature for 12 h, the reaction was completed, the reaction was quenched with excess methanol, filtered, and the bacteriostatic agent was obtained; Preparation of a pre-treatment mold: After the glove ceramic mold is cleaned with ionized water, it is immersed in a release agent solution containing zinc stearate (5% by mass), soaked for 20 seconds, and then dried at 70°C to obtain a pre-treatment mold; A preparation method of a high-elasticity medical rubber glove, comprising the following steps: B1. 65 parts of hydrogenated nitrile rubber and 35 parts of isoprene rubber are mixed in a mixer at 85°C for 15 minutes to ensure that the molecular chains of the two rubbers are fully entangled, thereby obtaining a uniform blended rubber; B2. In a high-speed disperser, 8 parts of nanocellulose and 22.5 parts of ethanol are mixed, and after ultrasonic treatment for 45 minutes, a stable suspension is obtained to avoid the influence of powder agglomeration on mechanical properties; B3. The blended rubber, 2.0 parts of a vulcanizing agent (0.8 parts of dicumyl peroxide and 1.2 parts of triallyl isocyanurate), 1.2 parts of antioxidant 1010, and 4 parts of a bacteriostatic agent are sequentially added to an open mill, and after thin passing 7 times at 65°C, the suspension is slowly added and mixed until the ethanol is completely volatilized, thereby obtaining a uniform rubber compound; B4. The pre-treatment mold is preheated to 65°C, then immersed in the rubber compound for 10 seconds, and after the dipping is completed, the mold is dried at 80°C for 10 minutes, then subjected to first-stage vulcanization at 160°C for 5 minutes, and then second-stage vulcanization at 180°C for 10 minutes, thereby obtaining a high-elasticity medical rubber glove.
[0027] Example 3 The difference between this example and Example 2 is that in this example, a preparation method of a high-elasticity medical rubber glove comprises the following steps: B1. 60 parts of hydrogenated nitrile rubber and 40 parts of isoprene rubber are mixed in a mixer at 90°C for 20 minutes to ensure that the molecular chains of the two rubbers are fully entangled, thereby obtaining a uniform blended rubber; B2. In a high-speed disperser, 10 parts of nanocellulose and 25 parts of ethanol are mixed, and after ultrasonic treatment for 60 minutes, a stable suspension is obtained to avoid the influence of powder agglomeration on mechanical properties; B3. The blended rubber, 2.5 parts of a vulcanizing agent (1.0 parts of dicumyl peroxide and 1.5 parts of triallyl isocyanurate), 1.6 parts of antioxidant 1076, and 6 parts of a bacteriostatic agent are sequentially added to an open mill, and after thin passing 8 times at 70°C, the suspension is slowly added and mixed until the ethanol is completely volatilized, thereby obtaining a uniform rubber compound; B4, the pre-treatment mold is preheated to 70 DEG C, then dipped into the rubber compound, and dipped for 15s, after dipping, dried at 80 DEG C for 10min, first vulcanization at 160 DEG C for 5min, then second vulcanization at 180 DEG C for 10min, after vulcanization, high elasticity medical rubber gloves are obtained.
[0028] Comparative Example 1 The difference between the present comparative example and Example 2 is that, in the present comparative example, an equal amount of hexadecyl trimethyl ammonium bromide is used to replace the bacteriostatic agent in Example 2 to prepare the gloves.
[0029] Comparative Example 2 The medical nitrile gloves produced by Inco Medical are used.
[0030] Examples 1-3 and Comparative Examples 1-2 are subjected to the following performance tests: The antibacterial performance is determined according to GB / T 5979 standard, and the test bacterial groups are Escherichia coli and Staphylococcus aureus; The tensile strength and elastic recovery rate are determined according to GB / T 528-2009 standard, and the elastic recovery rate = (retracted length after stretching / tensile length) x 100%.
[0031] The measured results are shown in Table 1: Table 1 Performance test results
[0032] As can be seen from the test results in Table 1, the gloves prepared in the examples have higher elasticity and mechanical properties than Comparative Example 2, and higher antibacterial properties than Comparative Example 1, and thus the present application has important application value in the field of rubber gloves.
[0033] The above is only a preferred embodiment of the present application, and is not intended to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.
Claims
1. A highly elastic medical rubber glove, characterized in that: The invention comprises the following raw materials in parts by weight: 60-70 parts of hydrogenated nitrile rubber, 30-40 parts of isoprene rubber, 6-10 parts of nanocellulose, 20-25 parts of ethanol, 1.5-2.5 parts of vulcanizing agent, 0.8-1.6 parts of antioxidant and 2-6 parts of antibacterial agent.
2. A highly elastic medical rubber glove according to claim 1, characterized in that: The antibacterial agent is prepared by the following steps: A1. Add 2,6-dichloropyridine, 7-hydroxycoumarin, and chloroform to a flask and stir evenly at room temperature. Then, mix sodium hydroxide with deionized water and add the mixture dropwise to the flask. After the addition is complete, heat to 65-70°C and reflux for 5-6 hours. The reaction is complete to obtain a primary product. A2. Add the initial product, bromobutane and chloroform into a flask, stir evenly at room temperature, heat to 70-75°C for condensation and reflux, and react for 10-12 hours. When the reaction is complete, an antibacterial agent is obtained.
3. The high-elastic medical rubber glove according to claim 1, characterized in that: In step A1, the ratio of 2,6-dichloropyridine, 7-hydroxycoumarin, chloroform, sodium hydroxide and deionized water is 14.6 g:33.5-37.1 g:120 mL:8.5-9.3 g:30 mL.
4. The high-elastic medical rubber glove according to claim 1, characterized in that: The ratio of the initial product, bromobutane and chloroform used in step A2 is 39.9 g:17.1-18.3 g:120 mL.
5. The high-elastic medical rubber glove according to claim 1, characterized in that: The vulcanizing agent is prepared by mixing dicumyl peroxide and triallyl isocyanurate in a mass ratio of 2:
3.
6. The high-elasticity medical rubber glove according to claim 1, characterized in that: The antioxidant is one of antioxidant 1010, antioxidant 168 and antioxidant 1076.
7. A method for preparing a highly elastic medical rubber glove, for preparing the highly elastic medical rubber glove according to any one of claims 1 to 6, characterized in that: The following steps are involved: B1, mixing hydrogenated nitrile rubber and isoprene rubber in an internal mixer to obtain a blended rubber; B2. In a high-speed disperser, the nanocellulose is mixed with ethanol and subjected to ultrasonic treatment to obtain a suspension; B3. Add the blended rubber, vulcanizing agent, antioxidant and antibacterial agent to the open mill in sequence, pass it through the mill 6-8 times at 60-70°C, then slowly add the suspension and mix until the ethanol is completely evaporated to obtain a uniform rubber compound; B4. Preheat the pretreatment mold, then immerse it in the rubber material for dipping. After dipping, dry it, and perform two-stage vulcanization. After vulcanization, high-elasticity medical rubber gloves are obtained.
8. The method for preparing a highly elastic medical rubber glove according to claim 7, characterized in that: The dipping time in step B4 is 10-15 seconds.
9. The method for preparing a highly elastic medical rubber glove according to claim 7, characterized in that: The pretreatment mold is prepared by the following steps: After cleaning the glove ceramic mold with ionized water, immerse it in a release agent solution containing zinc stearate for 10-20 seconds, take it out, and dry it at 60-70°C to obtain a pretreated mold.