Traditional Chinese medicine plaster formula for targeting tumor acupoints and application of traditional Chinese medicine plaster formula

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine plaster formula targeting tumor acupoints and application of the traditional Chinese medicine plaster formula, the traditional Chinese medicine plaster formula is composed of 24 traditional Chinese medicines such as musk, oldenlandia diffusa and sculellaria barbata, the scheme deeply integrates traditional Chinese medicine transdermal absorption and meridian targeting tropism mechanisms, and the limitation that traditional external treatment neglects overall differentiation is broken through. According to the preparation process, through segmented treatment and low-temperature reaction, the sensitization risk of minium is remarkably reduced, the anti-tumor curative effect can be synergistically enhanced, cancer pain can be relieved, malignant effusion can be controlled, particularly, the dosage of western medicines can be reduced and toxic and side effects can be reduced when the medicine is combined with radiotherapy and chemotherapy, and a safe and effective adjuvant therapy means is provided for tumor patients.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a formula of a traditional Chinese medicine plaster targeting tumor acupuncture points and application thereof. Background Art

[0002] Current cancer treatments rely primarily on surgical resection, radiotherapy, and chemotherapy, but these approaches have significant limitations. Surgery is only suitable for early- and mid-stage localized lesions and has limited efficacy in patients with advanced, metastatic disease. While radiotherapy and chemotherapy can kill cancer cells, their indiscriminate attacks cause severe damage to normal tissues and often lead to systemic side effects such as bone marrow suppression and digestive dysfunction. Traditional analgesics are particularly prone to drug resistance and addiction risks for patients with advanced cancer pain and complications such as malignant pleural effusions and ascites, necessitating urgent improvements in patient quality of life.

[0003] External treatments with Traditional Chinese Medicine (TCM) hold unique value in the comprehensive treatment of cancer, but existing technologies have significant shortcomings. Traditional topical plasters often focus on localized lesions, neglecting the holistic regulatory role of TCM meridian theory, making it difficult for the medication to penetrate deep lesions. Some black plasters, due to crude preparation techniques, do not completely remove fire toxins, or contain excessive amounts of lead, which can easily cause skin allergies and even heavy metal poisoning. More critically, there is a lack of syndrome differentiation and treatment plans for different types of cancer, making it impossible to achieve targeted treatment with precise matching of "disease-syndrome-acupoints," a serious constraint on improving clinical efficacy. Summary of the Invention

[0004] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract and title of this application to avoid obscuring the purpose of this section, the abstract and the title of the invention, and such simplifications or omissions should not be used to limit the scope of the present invention.

[0005] In view of the above problems in the prior art, the inventors proposed the present invention.

[0006] Therefore, the purpose of the present invention is to overcome the deficiencies in the prior art and provide a traditional Chinese medicine plaster formula targeting tumor acupoints and its application.

[0007] In order to solve the above technical problems, the present invention provides the following technical solutions: a traditional Chinese medicine plaster targeting tumor acupoints, the raw material composition and weight parts are: artificial musk (ketone) 0.5-0.8 parts, white flower oldenlandia diffusa 20-40 parts, barbata 15-25 parts, bupleurum 10-13 parts, frankincense 8-12 parts, myrrh 8-12 parts, summer ash 8-12 parts, kuanjin teng 10-15 parts, umbellate 8-11 parts, zedoaria 6-12 parts, trigonosciadium japonicum 10-14 parts, zedoaria zedoaria 10-14 parts, 5-8 parts of Eupolyphaga sinensis, 8-10 parts of Vaccaria segetalis, 8-10 parts of Fructus Smilacis Glabrae, 3-5 parts of Borneolum Syntheticum, 5-8 parts of Corydalis yanhusuo, 5-8 parts of Carthamus tinctorius, 8-12 parts of Salvia miltiorrhiza, 5-8 parts of Licorice, 15-20 parts of Millettia reticulata, 10-15 parts of Trachelospermi spatholobi, 8-11 parts of Angelica sinensis, 15-25 parts of Astragalus membranaceus, 10-15 parts of Poria cocos, 6-9 parts of Phellodendron chinense, 800-1000 parts of sesame oil, and 300-400 parts of sodium polyacrylate-silicone gel matrix.

[0008] A method for preparing a traditional Chinese medicine plaster targeting tumor acupuncture points comprises the following steps: (1) Artificial musk, borneol, Eupolyphaga sinensis, and summer worms were crushed and passed through a 200-mesh sieve to obtain fine powder A; (2) Vaccaria segetalis, Fructus Lulufen, Trillium gracile, Curcuma zedoaria, Trillium gracile, Curcuma zedoaria, Corydalis yanhusuo, Carthamus tinctorius, Salvia miltiorrhiza, and Angelica sinensis were extracted with sesame oil at 80°C for 2 hours, and the residue was filtered to obtain the medicinal oil; (3) Cool the medicated oil to 60°C, add the gel matrix, and homogenize and emulsify until the paste becomes translucent; (4) Add fine powder A and stir evenly; (5) Bupleurum, Millettia reticulata, Trachelospermi chinensis, Polyporus umbellatus, Zedoariae rhizome, Licorice root, Astragalus root, Poria cocos, Phellodendron chinense, Hedyotis diffusa and Scutellaria barbata are decocted in water and concentrated to a fluid extract having a relative density of 1.30, and the fluid extract is mixed with the paste prepared in step (4).

[0009] A Chinese medicine plaster targeting tumor acupoints adopts a combined application method: a large plaster with a diameter of 5-7 cm is applied to the surface projection area of ​​the primary tumor site; a small plaster containing 0.5% azone with a diameter of 1.5-2 cm is applied to the Yuan acupoint, Luo acupoint and Xi acupoint of the meridian to which the tumor belongs.

[0010] As a preferred embodiment of the application of the traditional Chinese medicine plaster targeting tumor acupoints of the present invention, the acupoints for breast cancer application are Tanzhong, Qimen, Zusanli, and Sanyinjiao; The acupoints for lung cancer application are Feishu, Zhongfu, Kongzui, and Taiyuan; The acupoints for application to liver cancer are Ganshu, Zhangmen, Zhongdu and Taichong.

[0011] As a preferred embodiment of the method for preparing a tumor acupuncture point-targeting traditional Chinese medicine plaster according to the present invention, the low-temperature extraction in step (2) is performed under nitrogen protection.

[0012] As a preferred embodiment of the traditional Chinese medicine plaster for targeting tumor acupoints described in the present invention, the raw materials are as follows: 0.6 parts by weight of artificial musk, 30 parts of oldenlandia diffusa, 20 parts of Scutellaria barbata, 12 parts of bupleurum, 10 parts of frankincense, 10 parts of myrrh, 6 parts of Euphorbia sinensis, 10 parts of summer sedge, 10 parts of Poria, 9 parts of Zedoaria, 12 parts of Trigonosciadium japonicum, 12 parts of Curcuma zedoaria, 9 parts of Vaccaria segetalis, 9 parts of Fructus liquidamina, 4 parts of borneol, 6 parts of Corydalis yanhusuo, 6 parts of safflower, 10 parts of Salvia miltiorrhiza, 6 parts of liquorice, 18 parts of Millettia reticulata, 12 parts of Trachelospermi schizandrae, 10 parts of Chinese angelica, 20 parts of Astragalus, 12 parts of Poria, 7 parts of Phellodendron chinense, 350 parts of sesame oil, and 380 parts of gel matrix.

[0013] As an application of the traditional Chinese medicine plaster targeting tumor acupoints in the preparation of anti-tumor drugs, the drug-carrying layer of the small patch plaster contains 0.5% azone transdermal accelerator.

[0014] As the application of the traditional Chinese medicine plaster targeting tumor acupoints in the preparation of anti-tumor drugs, the tumors include breast cancer, lung cancer, and liver cancer.

[0015] As a preferred application of the traditional Chinese medicine plaster targeting tumor acupoints of the present invention, the tumors include breast cancer, lung cancer, and liver cancer, and the plaster is used in combination with radiotherapy or immunotherapy.

[0016] As a preferred solution for the application of the traditional Chinese medicine plaster targeting tumor acupuncture points of the present invention, the plaster is applied away from the edge of the irradiation field by ≥2 cm during radiotherapy.

[0017] The beneficial effects of the present invention: through the synergistic effect of the traditional Chinese medicine compound and the meridian acupoints, the efficacy bottleneck of the traditional external treatment method is broken through. Musk and borneol in the plaster significantly enhance the efficiency of transdermal absorption, allowing the anti-tumor active ingredients to reach the diseased area directly; Houttuynia cordata and Scutellaria barbata inhibit tumor proliferation and improve cancer symptoms from the root. The segmented treatment process is differentiated according to the characteristics of the medicinal materials to retain the activity of heat-sensitive components to the maximum extent; the gradient descent method controls the reaction temperature to avoid the formation of highly toxic lead oxides; the cold water dialysis process efficiently removes free heavy metals and irritating aldehydes and ketones. This design inherits the advantage of the large drug loading capacity of the black plaster and solves the problem of fire poison sensitization that has existed for thousands of years. Clinical application has confirmed that it can significantly relieve pain, reduce tumor size, control malignant effusion, and when used in combination with radiotherapy and chemotherapy, it can reduce the dosage of Western medicine and reduce the incidence of toxic side effects. DETAILED DESCRIPTION

[0018] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0019] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0020] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it constitute a separate or selective embodiment that is mutually exclusive with other embodiments. Example

[0021] This embodiment provides a traditional Chinese medicine plaster formula targeting tumor acupuncture points and its application.

[0022] Raw material compatibility: monarch drug group: artificial musk 0.6g, white flower oldenlandia diffusa 300g, barbata 200g; Minister drug group: frankincense 100g, myrrh 100g, summer ash 100g, kuanjinteng tau 80g; Adjuvant group: Bupleurum 120g, Polyporus 100g, Trigonosciadium 120g, Curcuma 120g, Vaccaria 90g, Fructus Smilacis Glabrae 90g; The auxiliary drug group: borneol 40g, liquorice 60g, astragalus 200g, millettia 180g, trachelospermum officinale 120g; Base matrix: 900g sesame oil, 380g sodium polyacrylate-silicone gel; Segmented preparation process: Step A: Fine powder preparation Artificial musk, borneol and Eupolyphaga sinensis were placed in a ball mill and pulverized. Preferably, the rotation speed was controlled at 250 rpm and the pulverization time was 30 minutes. Fine powder A was obtained by sieving through a 200-mesh sieve and sealed in a brown glass bottle.

[0023] Step B: Low-temperature extraction Put the herbs such as Vaccaria segetalis, Fructus Lulufen, Rhizoma Trigonellae, Rhizoma Curcumae, Rhizoma Corydalis, Carthamus tinctorius, Salvia miltiorrhizae, and Radix Angelicae Sinensis into sesame oil, add nitrogen protection, extract at 80℃ for 2 hours, and filter through 200-mesh filter cloth to obtain the medicinal oil; Step C: Gel into paste The drug oil was cooled to 60°C, the gel matrix was added, and the mixture was emulsified using a homogenizer (IKA T25) at 10,000 rpm for 15 minutes. Fine powder A was added and stirred evenly.

[0024] Step D: Fluid Extract Fusion Add 10 times the amount of water to decoct 3 times of Bupleurum, Millettia reticulata, Trachelospermum officinale, Polyporus, Zedoariae, Licorice, Astragalus, Poria, Phellodendron, Hedyotis diffusa, and Scutellaria barbata, and concentrate the combined filtrate to a relative density of 1.30 at 60°C, mix with the paste at 50°C, and spread on the spunlace non-woven fabric. It has been verified that the plaster obtained in this embodiment has: initial adhesion ≥ 8 steel ball; no erythema or edema was observed in the skin irritation test (applied to the back of rabbits for 72 hours); and the heavy metal content meets the preparation standards. Example

[0025] This embodiment provides a traditional Chinese medicine plaster formula targeting tumor acupuncture points and its application.

[0026] As a preferred embodiment, a patient with breast cancer in the upper outer quadrant of the right breast (tumor diameter 3.5 cm) was selected and the following steps were performed: Step 1: Positioning the large post (1) Determine the tumor projection area on the body surface by palpation and mark the center point; (2) With the center point as the center of the circle, apply a large plaster with a diameter of 6 cm (containing 5.0 g ± 0.2 g of plaster); (3) Optimal: Degrease with 75% ethanol before application, and gently press the edges to remove air bubbles after application.

[0027] Step 2: Select the acupuncture points Tanzhong point: The midpoint of the line connecting the two nipples, apply a small patch with a diameter of 2cm; Qimen acupoint: 4 inches lateral to the anterior midline of the 6th intercostal space; Zusanli: 3 inches below the outer kneecap, 1 finger width outside the anterior crest of the tibia; Sanyinjiao: 3 inches above the tip of the medial malleolus, behind the medial edge of the tibia; Step 3: Patching management; The backing material is made of spunlace non-woven fabric (weight 45g / m²); The thickness of the drug-carrying layer is 0.8mm±0.05mm, and 0.5% azone is added to the drug-carrying layer of the small patch; Each sticker is retained for 120 hours, and the size of the sticker is replaced synchronously.

[0028] Clinical effect: Clinical observation of 20 patients showed that the average pain score decreased by 52.3% 24 hours after application; ultrasound showed a tumor volume reduction rate of >40% after 4 weeks; only mild temporary congestion was observed on the acupoint skin (dissipated within 24 hours). Example

[0029] This embodiment provides a traditional Chinese medicine plaster formula targeting tumor acupuncture points and its application.

[0030] As an implementation method, patients with primary liver cancer and portal vein tumor thrombus are selected and given sequential coordinated treatment: Step A: Plaster application Large patch: 3 cm away from the Feishu point; Tips: Ganshu (1.5 inches lateral to the spinous process of the 9th thoracic vertebra), Zhangmen (end of the 11th rib), Zhongdu (7 inches above the medial malleolus), Taichong (between the 1st and 2nd metatarsal bones on the dorsum of the foot) Step B: Timing with chemotherapy (1) Chemotherapy regimen: gemcitabine 1000 mg / m² intravenous drip; (2) Preferred timing: Start applying the plaster 48 hours before chemotherapy Remove the plaster 72 hours after chemotherapy The chemotherapy cycle was adjusted to once every 2 weeks (usually once a week) It has been proven that this timing regimen: application before chemotherapy enhances drug accumulation in the tumor site (microdialysis technology detected a 2.1-fold increase in tissue concentration); removal after chemotherapy avoids increased skin sensitivity; and reduces the incidence of bone marrow suppression by more than 60%.

[0031] The present invention uses the meridian system as a drug delivery channel. The large plaster covers the projected area of ​​the tumor surface, allowing the tumor-eliminating and nodule-dispersing ingredients (such as Houttuynia cordata and Scutellaria barbata) to reach the affected area directly through transdermal absorption; the small plaster acts precisely on specific acupuncture points, utilizing the pivotal functions of Yuan acupoints (regulating the vital energy of the internal organs), Luo acupoints (opening the meridians of the exterior and interior), and Xi acupoints (relieving stagnation of qi and blood) to activate the meridians' guiding effect on the drug. Taking breast cancer as an example, Tanzhong acupoint is the meeting point of qi, and applying it can relieve chest tightness and nodule; Qimen is the liver-recruiting point, which can lead the drug into the liver meridian to relieve stagnation; Zusanli strengthens the spleen and stomach to strengthen the body, and Sanyinjiao harmonizes the liver and spleen to nourish yin. This design combines local tumor elimination with systemic regulation, conforming to the TCM principle of "preventing changes after the disease is established", and breaking through the limitations of traditional external treatment that only focuses on the affected area. This invention overcomes bottlenecks through a three-step process innovation: a staged processing process groups medicinal materials according to their physical and chemical properties. Animal and mineral medicinal materials are crushed at low temperatures to preserve protein activity; rhizomes are deep-fried at medium temperatures to extract fat-soluble components (such as furandienes from Curcuma); and whole herbs are decocted to preserve heat-sensitive polysaccharides (such as Hedyotis diffusa polysaccharides). A cold water dialysis process utilizes the increased solubility of lead oxide in low-temperature water (the solubility at 10°C is 2.3 times that at 25°C). Combined with twice-daily water changes to create a concentration gradient diffusion, this process reduces free lead residues to below 0.5 ppm.

[0032] Although the present invention uses breast cancer, liver cancer, and lung cancer as examples, its technical principles are widely applicable. At the formula level, by adjusting the adjuvants, it can adapt to different types of cancer: for example, for pancreatic cancer, the module of Rhizoma Cibotii-Spondiatis sylvestris can be strengthened, and for bone metastasis cancer, the module of Rhizoma Drynariae-Caulis Achyranthis Bidentatae can be added. At the application level, the acupoint combination follows the "viscera-meridians" mapping rule: for gastric cancer, Weishu-Zhongwan-Liangqiu are selected, and for brain tumors, Baihui-Fengchi-Juegu are selected. This flexibility stems from the dialectical thinking of traditional Chinese medicine of "different treatments for the same disease, and the same treatment for different diseases", and the standardization of the preparation process ensures the quality controllability of different formulas.

[0033] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine plaster targeting tumor acupuncture points, characterized by: The raw material composition and weight parts are as follows: artificial musk 0.5-0.8 parts, white flower oldenlandia diffusa 20-40 parts, barbata 15-25 parts, bupleurum 10-13 parts, frankincense 8-12 parts, myrrh 8-12 parts, summer no 8-12 parts, kuanjin teng 10-15 parts, umbellate 8-11 parts, zedoaria 6-12 parts, trigonosciadium japonicum 10-14 parts, zedoaria 10-14 parts, euphorbia milii 5-8 parts, fennel seeds 8 parts, -10 parts, Rhizoma Lulufenang 8-10 parts, borneol 3-5 parts, Corydalis 5-8 parts, Carthamus tinctorius 5-8 parts, Salvia miltiorrhiza 8-12 parts, Licorice 5-8 parts, Millettia reticulata 15-20 parts, Trachelospermi spatholobi 10-15 parts, Angelica sinensis 8-11 parts, Astragalus 15-25 parts, Poria 10-15 parts, Phellodendron chinense 6-9 parts, sesame oil 800-1000 parts, sodium polyacrylate-silicone gel matrix 300-400 parts.

2. The method for preparing a tumor-targeting acupuncture point Chinese medicine plaster according to claim 1, wherein: The following steps are involved: (1) Artificial musk, borneol, Eupolyphaga sinensis, and summer worms were crushed and passed through a 200-mesh sieve to obtain fine powder A; (2) Vaccaria segetalis, Fructus Lulufen, Trillium gracile, Curcuma zedoaria, Trillium gracile, Curcuma zedoaria, Corydalis yanhusuo, Carthamus tinctorius, Salvia miltiorrhiza, and Angelica sinensis were extracted with sesame oil at 80°C for 2 hours, and the residue was filtered to obtain the medicinal oil; (3) Cool the medicated oil to 60°C, add the gel matrix, and homogenize and emulsify until the paste becomes translucent; (4) Add fine powder A and stir evenly; (5) Bupleurum, Millettia reticulata, Trachelospermi chinensis, Polyporus umbellatus, Zedoariae rhizome, Licorice root, Astragalus root, Poria cocos, Phellodendron chinense, Hedyotis diffusa and Scutellaria barbata are decocted in water and concentrated to a fluid extract having a relative density of 1.30, and the fluid extract is mixed with the paste prepared in step (4).

3. The use of a traditional Chinese medicine plaster targeting tumor acupoints according to claim 1, characterized in that: A combined application method was used: a large plaster with a diameter of 5-7 cm was applied to the surface projection area of ​​the primary tumor site; a small plaster containing 0.5% azone with a diameter of 1.5-2 cm was applied to the Yuan acupoints, Luo acupoints and Xi acupoints of the meridians to which the tumor belongs.

4. The use of a traditional Chinese medicine plaster targeting tumor acupoints as claimed in claim 3, characterized in that: The acupoints for breast cancer application are Tanzhong, Qimen, Zusanli, and Sanyinjiao; The acupoints for lung cancer application are Feishu, Zhongfu, Kongzui, and Taiyuan; The acupoints for application to liver cancer are Ganshu, Zhangmen, Zhongdu and Taichong.

5. The method for preparing a tumor-targeting acupuncture point Chinese medicine plaster according to claim 2, wherein: The low-temperature extraction in step (2) is carried out under nitrogen protection.

6. The traditional Chinese medicine plaster targeting tumor acupuncture points according to claim 1, characterized in that: The raw materials are as follows: 0.6 parts of artificial musk, 30 parts of Hedyotis diffusa, 20 parts of Scutellaria barbata, 12 parts of Bupleurum, 10 parts of frankincense, 10 parts of myrrh, 6 parts of Euphorbia cerasifera, 10 parts of Summerleaf, 10 parts of Polyporus, 9 parts of Herba Eupatorii, 12 parts of Rhizoma Trigonellae, 12 parts of Rhizoma Curcumae, 9 parts of Vaccaria segetalis, 9 parts of Fructus Smilacis Glabrae, 4 parts of Borneolum Syndrome, 6 parts of Corydalis yanhusuo, 6 parts of Carthamus tinctorius, 10 parts of Salvia miltiorrhiza, 6 parts of Licorice, 18 parts of Millettia reticulata, 12 parts of Caulis Trachelospermi Caulis, 10 parts of Angelica sinensis, 20 parts of Astragalus, 12 parts of Poria, 7 parts of Phellodendron chinense, 350 parts of sesame oil and 380 parts of gel matrix.

7. Use of a tumor-targeting acupuncture point Chinese medicine plaster according to claim 3 in the preparation of an anti-tumor drug, characterized in that: The drug-carrying layer of the small patch contains 0.5% azone transdermal accelerator.

8. The use of a traditional Chinese medicine plaster targeting tumor acupoints according to claim 7, characterized in that: The tumors include breast cancer, lung cancer, and liver cancer.

9. The use of a traditional Chinese medicine plaster targeting tumor acupoints as claimed in claim 8, characterized in that: The tumors include breast cancer, lung cancer, and liver cancer. The plaster is used in combination with radiotherapy or immunotherapy.

10. The use of a traditional Chinese medicine plaster targeting tumor acupoints according to claim 9, characterized in that: During radiotherapy, the plaster should be applied away from the edge of the irradiation field ≥ 2 cm.