Magnetic control targeted inner ear drug delivery method in cochlea

By using hollow mesoporous ferroferric oxide magnetic material carriers and magnetic resonance driving technology, the problem of uneven drug distribution in traditional inner ear drug delivery methods was solved, and precise targeted delivery and uniform distribution of inner ear drugs were achieved.

CN120771306APending Publication Date: 2025-10-14THE SIXTH MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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Patent Information

Application Number
CN202511162890.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-19
Publication Date
2025-10-14

AI Technical Summary

Technical Problem

Traditional inner ear drug delivery methods cannot achieve precise delivery to specific locations within the cochlea, resulting in uneven drug distribution and low utilization, as well as systemic side effects.

Method used

Hollow mesoporous ferrosoferric oxide was used as a magnetic material carrier, surface modified with polyethylene glycol, loaded with target drugs, and injected into the rat semicircular canals through minimally invasive drilling and a microinjection pump. The 9.4T magnetic resonance magnetic field was used to drive the directional movement of the drugs in the cochlear lymph to achieve targeted release.

Benefits of technology

It improves the efficiency and accuracy of drug delivery in the inner ear, reduces the risk of tissue damage and fluid overflow, and achieves uniform distribution and efficient delivery of drugs in the cochlea.

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Abstract

The invention provides an inner ear drug delivery method in a magnetic control targeting cochlea, and relates to the technical field of magnetic material application, and the method comprises the following steps: preparing a novel magnetic material carrier; the method comprises the following steps: after anesthetizing a rat, identifying occipital bone and positioning semicircular canals of the rat under an operating microscope, performing minimally invasive drilling by adopting a 1mL injector, and injecting a novel magnetic material carrier loaded with a target inner ear medicine into the semicircular canals of the rat; when the rat semicircular canal administration meets a preset time threshold value, the rat is placed in a 9.4 T magnetic resonance magnetic field, the magnetic field direction is from the bottom of the cochlea to the top of the cochlea, the target inner ear medicine is driven to move in the cochlea lymph, and target area release is executed. According to the invention, the technical problem that the medicine is difficult to uniformly and accurately distribute in the inner ear due to the fact that the medicine can only passively move along with cochlea lymph fluid and cannot be administrated to a specific part in the cochlea in a traditional inner ear local administration method is solved.
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