A drying device for roxithromycin bulk drug production

Abstract

The application discloses a drying device for roxithromycin bulk drug production, and relates to the technical field of bulk drug production equipment, which comprises a drying part and a detection part. The drying part is provided with a feeding port and a discharging port at two ends, and a bearing plate capable of vibrating up and down is arranged in the drying part. The detection part comprises a collecting cylinder capable of vertically rotating, the collecting cylinder is correspondingly connected to the discharging port position of the drying part, a detection assembly is arranged in the collecting cylinder, and the detection assembly is used for detecting the drying condition of the sampled bulk drug. A driving gear and a rack meshing with each other are arranged between the bearing plate and the collecting cylinder, the driving gear is rotationally connected to the drying part, a first bevel gear and a second bevel gear are further arranged, the first bevel gear is coaxially arranged with the driving gear, the first bevel gear meshes with the second bevel gear, the second bevel gear is coaxially fixed with the collecting cylinder, and the driving gear drives the first bevel gear to rotate in one direction at intervals through a one-way driving assembly. The application has the effect of improving the detection efficiency of the drying degree of the bulk drug.

Description

Technical Field

[0001] This application relates to the technical field of active pharmaceutical ingredient (API) production equipment, and in particular to a drying device for the production of roxithromycin API. Background Technology

[0002] Roxithromycin is a macrolide antibiotic primarily used to treat various infections caused by susceptible bacteria. It exerts its antibacterial effect by inhibiting bacterial protein synthesis. Roxithromycin raw material is the core component in the production of the finished roxithromycin drug. Its highly effective antibacterial properties and good safety profile make it one of the most commonly used antibiotics in clinical practice and a fundamental substance for pharmaceutical companies producing various dosage forms (such as tablets, capsules, granules, and injections).

[0003] Roxithromycin, as an antibiotic, contains a certain amount of moisture during its production process, whether through chemical synthesis or fermentation extraction. If this moisture is not removed, it will not only affect the stability of the drug, leading to degradation or deterioration, but also reduce the purity of the final product. Therefore, roxithromycin raw materials need to be dried during the production process.

[0004] Roxithromycin active pharmaceutical ingredient (API) typically exists in crystalline powder form. Therefore, fluidized bed drying is commonly used, where a high-temperature airflow continuously blows the API from bottom to top, causing the material to "boil" and ultimately achieving the desired dryness. After drying, the API needs to be tested for dryness to determine if it is completely dried. The conventional method is to randomly sample after the machine is stopped. However, this method can lead to over-drying or incomplete drying, both of which negatively impact the production quality of roxithromycin API. Summary of the Invention

[0005] To address the issue of over-drying or under-drying of active pharmaceutical ingredients (APIs) caused by routine downtime testing, this application provides a drying apparatus for the production of roxithromycin APIs.

[0006] This application provides a drying device for the production of roxithromycin raw material, which adopts the following technical solution:

[0007] A drying apparatus for the production of roxithromycin raw material, comprising:

[0008] The drying section is hollow inside and used to dry the raw materials. The drying section has an inlet and an outlet at both ends, and is equipped with a horizontally placed support plate that can vibrate up and down to evenly distribute the airflow for drying the raw materials.

[0009] The detection unit includes a collection cylinder that rotates relative to the drying unit with its rotation axis vertical. The collection cylinder is connected to the feed port of the drying unit and is used to sample the active pharmaceutical ingredient. The collection cylinder is equipped with a detection component for detecting the drying status of the sampled active pharmaceutical ingredient.

[0010] A drive gear and a rack are provided between the support plate and the collection cylinder. Both the drive gear and the rack are located below the support plate. The rack is vertically fixed to the bottom of the support plate and meshes with the drive gear. The drive gear is rotatably connected to the drying section and its rotation axis is horizontal. A first bevel gear and a second bevel gear are correspondingly provided at the bottom of the collection cylinder. The first bevel gear is coaxially arranged with the drive gear and meshes with the second bevel gear. The second bevel gear is coaxially fixed with the collection cylinder. A one-way drive assembly is provided between the drive gear and the first bevel gear so that the drive gear drives the first bevel gear to rotate unidirectionally at intervals.

[0011] Optionally, the end of the support plate near the detection part extends outward and enters the collection cylinder. A vertical auxiliary vibration element is provided at the end of the support plate near the detection part. The auxiliary vibration element includes an output shaft that can extend and retract vertically. A vibration ball is provided at the end of the output shaft. A detection chamber is vertically slidably connected inside the collection cylinder. A vibration ring is provided at the top of the detection chamber. The vibration ring extends horizontally outward outside the collection cylinder. The vibration ball is correspondingly provided above the vibration ring to transmit the vibration of the support plate to the detection chamber. The detection component is correspondingly provided on the inner top wall of each detection chamber.

[0012] Optionally, multiple detection chambers are provided and are circumferentially distributed along the axis of the collection cylinder. Along the radial direction of the collection cylinder, the outer walls of all detection chambers are vertically slidably connected to the inner wall of the collection cylinder. The vibration ring is simultaneously connected to the top of all detection chambers so that the multiple detection chambers move together as a whole. Each detection chamber has a corresponding sampling port on its top wall. Each sampling port is used to collect and sample materials at different radii within the collection cylinder. Each detection chamber has an openable and closable outlet at its bottom.

[0013] Optionally, each of the detection chambers is provided with a sealing cap at the sampling port. The sealing cap is connected to the detection chamber through an elastic connector. When the detection chamber vibrates, the sealing cap vibrates synchronously with the detection chamber to close or open the sampling port.

[0014] Optionally, along the radial direction of the collection cylinder, the top walls of all the detection chambers are inclined downwards.

[0015] Optionally, the top wall of each of the detection chambers is provided with multiple spaced-apart dispersing columns, each of which is perpendicular to the plane of the top wall.

[0016] Optionally, the top surface of the bearing plate is provided with multiple rows of guide plates, which are distributed at intervals along the direction from the feed inlet to the discharge outlet. All guide plates are inclined upward and their tops extend towards the discharge outlet.

[0017] Optionally, the unidirectional drive assembly includes a ratchet, a turntable, a locking tooth, and a spring. The ratchet is coaxial and rotatably connected to the outer ring of the turntable. The inner ring wall of the ratchet has a plurality of spaced inner ring tooth grooves distributed circumferentially. The turntable is coaxially fixed to the drive gear, and the ratchet is coaxially fixed to the first bevel gear. One end of the locking tooth is rotatably connected to the turntable, and the other end of the locking tooth extends outward and engages in the inner ring tooth groove. The end of the locking tooth away from the turntable abuts against one side wall of the ratchet in the inner ring tooth groove. The spring is used to keep the locking tooth engaged with the inner ring tooth groove of the ratchet.

[0018] In summary, this application includes at least one of the following beneficial effects:

[0019] 1. By employing a gear and rack meshing structure, the up-and-down vibration of the receiving plate is converted into the reciprocating rotation of the drive gear via the rack. The reciprocating rotation of the drive gear is then converted into the unidirectional interval rotation of the ratchet mechanism in the unidirectional drive assembly. Finally, the meshing first and second bevel gears further drive the collecting cylinder to achieve unidirectional interval rotation. The detection chamber inside the collecting cylinder also rotates unidirectionally with the collecting cylinder. During continuous rotation, the detection chamber can sample materials at different locations within the collecting cylinder, improving the accuracy of the detection. At the same time, the distance between the sampling port on each detection chamber and the central axis of the collecting cylinder is different, allowing each detection chamber to collect materials from different parts of the falling material from the inner to the outer ring during rotation, further enhancing the randomness of sampling and facilitating comprehensive detection of material dryness. The entire sampling and detection operation is carried out simultaneously during the feeding process, thereby achieving online sampling and online detection and reducing the impact on the production progress of the raw material.

[0020] 2. By installing a sealing cap on the top wall of each testing chamber, and elastically connecting the sealing cap to the top wall of the testing chamber via an elastic connector, and simultaneously installing an auxiliary vibrating component at the end of the receiving plate, when the testing chamber needs to vibrate, the output shaft of the auxiliary vibrating component extends, allowing the vibrating ball at the end to vibrate and contact the vibrating ring at the top of the testing chamber. The vibrating ball continuously vibrates and impacts the vibrating ring, causing the testing chamber to vibrate as well. At this time, the sealing cap will also vibrate. Due to the elastic connection of the elastic connector, the sealing cap remains connected to the testing chamber during vibration. The sealing cap will continuously open and close the sampling port during vibration, allowing the sampling port to switch back and forth between open and closed states. The raw material can enter the testing chamber through the gap in the open sampling port to complete the sampling of the material. At the same time, when the testing chamber vibrates up and down, it can also vibrate and flatten the material already collected inside the testing chamber, facilitating subsequent testing and thus effectively improving the accuracy of the test. Attached Figure Description

[0021] Figure 1 This is a schematic diagram illustrating the overall structure of the drying apparatus according to an embodiment of this application;

[0022] Figure 2 This is a cross-sectional schematic diagram illustrating the interior of the drying apparatus according to an embodiment of this application;

[0023] Figure 3 This is a partial cross-sectional schematic diagram illustrating the rotation principle of the inner cylinder in an embodiment of this application;

[0024] Figure 4 This is a schematic diagram illustrating the structure of a unidirectional drive component according to an embodiment of this application;

[0025] Figure 5 This is a partial schematic diagram illustrating the internal structure of the inner cylinder according to an embodiment of this application;

[0026] Figure 6 This is a cross-sectional schematic diagram illustrating the internal structure of the inner cylinder according to an embodiment of this application;

[0027] Figure 7 yes Figure 6 An enlarged view at point A.

[0028] Explanation of reference numerals in the attached drawings: 1. Drying section; 11. Feed inlet; 12. Discharge outlet; 13. Support plate; 131. Guide plate; 132. Air jet hole; 133. Drive gear; 134. Rack; 14. Vibrating component; 2. Detection section; 21. Collection cylinder; 211. Inner cylinder; 212. Outer cylinder; 213. First bevel gear; 214. Second bevel gear; 215. Support ring; 216. Vibration spring; 22. Fixing frame; 23. Detection chamber; 231. Vibration ring; 232. Sampling port; 233. Outlet; 234. Dispersing column; 235. Sealing cap; 236. Elastic connector; 3. One-way drive assembly; 31. Ratchet; 311. Inner ring tooth groove; 32. Turntable; 33. Clamping tooth; 34. Spring; 4. Auxiliary vibrating component; 41. Vibrating ball; 5. Detection instrument. Detailed Implementation

[0029] The following is in conjunction with the appendix Figure 1-7 This application will be described in further detail.

[0030] This application discloses a drying apparatus for the production of roxithromycin raw material, referring to... Figure 1 and Figure 2The drying device for the production of roxithromycin raw material includes a drying section 1 and a detection section 2 that are independent of each other. In the embodiments of this application, the drying section 1 is preferably a hollow fluidized bed for fully drying the raw material. The detection section 2 is correspondingly arranged on the feeding side of the drying section 1, and can take real-time samples of the raw material after drying in the drying section 1 and detect the degree of dryness.

[0031] The drying section 1 has a rectangular parallelepiped shape. Along its length, it has an inlet 11 and an outlet 12 at both ends, used for pouring in the raw material to be dried and unloading the dried raw material, respectively. The bottom of the drying section 1 is fixed with support legs, which can lift the drying section 1 and detach it from the ground. The support legs are preferably equipped with cushioning structures such as air cushions or spring pads, allowing them to absorb excess vibration during operation and thus making the drying section 1 work more stably.

[0032] A support plate 13 is slidably disposed inside the drying section 1. The support plate 13 is placed horizontally and vertically slidably connected to the inner wall of the drying section 1. A vertical guide rail can be fixed to the inner wall of the drying section 1. The side wall of the support plate 13 is slidably connected to the guide rail, which allows the support plate 13 to slide stably and vertically within the drying section 1. The side wall of the support plate 13 is sealed to the inner wall of the drying section 1. A vibrating element 14 is fixed to the outer wall of the drying section 1. The vibrating element 14 is preferably a mechanical oscillator. The output end of the vibrating element 14 is fixedly connected to the support plate 13, so that the vibration generated by the vibrating element 14 can drive the support plate 13 to vibrate vertically in a regular manner within the drying section 1. The amplitude and frequency of the vibration of the support plate 13 can be adjusted according to the specific drying conditions, so that the vibration of the support plate 13 can promote the drying of the raw material to a greater extent.

[0033] Multiple rows of parallel guide plates 131 are fixed to the upper surface of the support plate 13. Along the direction from the feed inlet 11 to the discharge outlet 12, the multiple rows of guide plates 131 are spaced apart, all of which are inclined upwards and extend towards the discharge outlet 12. Multiple air jet holes 132 are provided through each pair of adjacent rows of guide plates 131 on the support plate 13. Simultaneously, a heating box is fixed below the support plate 13 in the drying section 1. An electric heating element, preferably an electric heating wire, is fixed inside the heating box. The heating box is connected to an external air supply device such as a fan via an air duct, allowing the drying airflow to be introduced into the heating box for heating. The heating box may also be equipped with a filter plate and a sterilizing lamp, etc., to maintain the purity of the airflow used to dry the raw pharmaceutical material. Multiple accelerating fans are fixed to the top of the heating chamber, which actively accelerate the pre-heated airflow inside the chamber and blow it toward the support plate 13. The support plate 13 effectively distributes the hot airflow evenly. The accelerated airflow is then ejected upwards from each jet hole 132, blowing the raw material to a "boiling" state, thereby thoroughly drying the raw material. The inclined guide plate 131 effectively guides the airflow to blow obliquely toward the raw material, so that the raw material, while being suspended by the airflow, gradually moves toward the discharge port 12, facilitating its subsequent discharge from the discharge port 12. In other embodiments of this application, the jet holes 132 can be replaced with jet nozzles. Each jet nozzle is connected to the accelerating fans through a duct. The heated airflow is finally ejected from the jet nozzles, which effectively prevents the raw material from falling out of the jet holes 132 and reduces the loss of the raw material during the drying process.

[0034] Furthermore, refer to Figure 2 and Figure 3The detection unit 2 is connected to the discharge port 12 of the drying unit 1. The detection unit 2 includes a collection cylinder 21, which is equipped with a detection component. The dried raw material falls from the support plate 13 and into the collection cylinder 21 through the discharge port 12. The raw material is sampled and its dryness is detected in real time. A collection device can be placed below the collection cylinder 21. Finally, the raw material passes through the collection cylinder 21 and falls into the collection device for centralized collection. The collection cylinder 21 includes an inner cylinder 211 and an outer cylinder 212 arranged coaxially. The inner cylinder 211 is rotatably connected to the outer cylinder 212, and the axis of rotation is vertical. The outer wall of the outer cylinder 212 is directly fixed to the outer wall of the drying unit 1 through a fixing frame 22. A vertical placement frame can also be set on the outer wall of the outer cylinder 212 so that it can be placed directly and stably on the ground. The bottom of the inner cylinder 211 extends downwards outwards from the outer cylinder 212. The detection assembly includes a detection chamber 23, which is vertically slidably connected to the inner wall of the inner cylinder 211. A guide block is also fixed on the inner wall of the inner cylinder 211 at the position corresponding to the detection chamber 23. A groove is opened on the outer wall of the detection chamber 23, and the guide block is slidably connected to the groove. This allows the detection chamber 23 to slide vertically within the inner cylinder 211 and rotate synchronously with the inner cylinder 211. The rotating detection chamber 23 can sample different positions of the falling raw material, greatly improving the randomness of sampling and making the sampling coverage wider, effectively improving the accuracy of subsequent detection.

[0035] Furthermore, to enable the detection chamber 23 to rotate with the vibration of the support plate 13, a drive gear 133 and a rack 134 are provided below the support plate 13. The rack 134 is placed vertically and meshes with the drive gear 133. To avoid the operation of the drive gear 133 affecting the operation of the drying section 1, the drive gear 133 is preferably located outside the drying section 1 and can be rotatably connected to the drying section 1 via a connecting frame, with the axis of rotation being horizontal. The lower end of the rack 134 extends out of the drying section 1 and is slidably connected to the inner wall of the drying section 1. A first bevel gear 213 and a second bevel gear 214 are correspondingly provided at the bottom of the collection cylinder 21. The first bevel gear 213 is coaxially arranged with the drive gear 133, meshes with the second bevel gear 214, and the second bevel gear 214 is coaxially fixed with the inner cylinder 211.

[0036] A one-way drive assembly 3 is provided between the drive gear 133 and the first bevel gear 213. The one-way drive assembly 3 includes a ratchet 31, a turntable 32, a locking tooth 33, and a spring 34. The ratchet 31 is coaxially and rotatably connected to the outer ring of the turntable 32. The turntable 32 is coaxially fixed to the drive gear 133 via a rotating shaft. The ratchet 31 is coaxially fixed to the first bevel gear 213 via a rotating shaft. The ratchet 31 can be fixedly connected to the rotating shaft via a fixing ring. The fixing ring is coaxially fixed to the side wall of the ratchet 31 and is also fixedly connected to the rotating shaft. The ratchet 31 and the two sections of the rotating shaft are rotatably connected to the bottom of the drying section 1 via connectors. The inner ring wall of the ratchet 31 has a plurality of spaced inner ring tooth grooves 311. One end of the locking tooth 33 is rotatably connected to the outer wall of the turntable 32, and the other end of the locking tooth 33 extends outward and engages with the corresponding inner ring tooth groove 311. When the locking tooth 33 engages in one of the inner ring tooth grooves 311, the end of the locking tooth 33 away from the turntable 32 abuts against one side wall of the ratchet 31 in the inner ring tooth groove 311. The spring piece 34 is an outwardly protruding arc shape, with both ends of the spring piece 34 engaging with the turntable 32. The outwardly protruding part of the spring piece 34 abuts against the locking tooth 33 to keep the locking tooth 33 engaged with the inner ring tooth groove 311 of the ratchet 31. At this time, the turntable 32 can drive the ratchet 31 to rotate synchronously through the locking tooth 33. The turntable 32 and the drive gear 133 are coaxially fixed through the transmission shaft, while the ratchet 31 is coaxially fixed with the first bevel gear 213 through the transmission cylinder.

[0037] When the rack 134 moves upward with the support plate 13, the drive gear 133 is driven to rotate in the forward direction by the rack 134. When the turntable 32 rotates forward with the drive gear 133, the turntable 32 drives the ratchet 31 to rotate forward through the locking teeth 33. At this time, the first bevel gear 213 rotates forward with the turntable 32, and the second bevel gear 214 drives the inner cylinder 211 to rotate. At this time, the detection chamber 23 rotates accordingly. When the turntable 32 rotates in reverse with the drive gear 133, the locking teeth 33 do not engage with the inner ring tooth groove 311. At this time, the turntable 32 cannot drive the ratchet 31 to rotate through the locking teeth 33. Therefore, the ratchet 31, the first bevel gear 213 and the second bevel gear 214 all remain stationary. At this time, the detection chamber 23 and the inner cylinder 211 all remain stationary, thereby realizing unidirectional and intermittent rotational sampling of the detection chamber 23. This allows the detection chamber 23 to sample materials at different positions during continuous rotation, improving the accuracy of the detection.

[0038] Furthermore, refer to Figures 2 to 5To ensure that the detection chamber 23 vibrates together with the support plate 13, so that the raw materials collected in the detection chamber 23 can be flattened, the support plate 13 extends outward from the end near the detection section 2 and enters the collection cylinder 21. The outer cylinder 212 has a corresponding receiving groove on its side wall for the support plate 13 to be placed in. The inner cylinder 211 is located below the support plate 13. A vertical auxiliary vibrating element 4 is provided at the end of the support plate 13 near the detection section 2. The auxiliary vibrating element 4 can preferably be a telescopic cylinder. The auxiliary vibrating element 4 includes a vertically downward output shaft that can be vertically extended and retracted. A vibrating ball 41 is rolledly connected to the end of the output shaft of the auxiliary vibrating element 4. A vibration ring 231 is fixed at the top of the detection chamber 23 and can move with the detection chamber 23. The vibration ring 231 extends horizontally outward from the outside of the outer cylinder 212. The vibration ball 41 is correspondingly set above the vibration ring 231, and a support ring 215 is fixed on the outer wall of the outer cylinder 212 at the position corresponding to the vibration ring 231. The vibration ring 231 and the support ring 215 are connected by a vibration spring 216, so that there is a gap between the vibration ring 231 and the support ring 215. To prevent the vibration ring 231 from rotating, a telescopic rod (not shown) can be inserted inside the vibration ring 231 to keep the vibration spring 216 in a fixed position. At the same time, a slider is fixed to the top of the vibration spring 216 and is slidably connected to the bottom surface of the vibration ring 231. Meanwhile, a conical baffle with a gradually decreasing diameter can be fixed to the top surface of the vibration ring 231. The baffle is made of soft rubber material and can vibrate synchronously with the vibration ring 231. The baffle can also reduce the occurrence of raw materials falling out of the inner cylinder 211. In addition, to prevent the raw materials from falling out of the inner cylinder 211, a flexible ring cover is fixed to the top of the inner cylinder 211. The top of the flexible cover is fixedly connected to the vibration ring 231 and can deform with the up and down vibration of the vibration ring 231.

[0039] When the detection chamber 23 needs to vibrate along with the support plate 13, the output shaft of the auxiliary vibrator 4 extends until the vibrating ball 41 contacts the vibrating ring 231. At this time, the support plate 13 drives the vibrating ring 231 to vibrate together with the detection chamber 23 through the vibrating ball 41, so as to vibrate and flatten the material inside the detection chamber 23. When the detection chamber 23 needs to stop vibrating, the auxiliary vibrator 4 only needs to retract its output shaft, so that the vibrating ball 41 disengages from the vibrating ring 231. The extension and retraction of the output shaft of the auxiliary vibrator 4 can be directly controlled by the PLC control unit to achieve automatic operation.

[0040] Furthermore, refer to Figures 5 to 6Multiple detection chambers 23 are provided and are circumferentially spaced along the axis of the collection cylinder 21. In this embodiment, two detection chambers 23 are preferably arranged symmetrically with respect to the axis of the collection cylinder 21, with a gap between the inner walls of the two detection chambers 23. The vibrating ring 231 is fixedly connected to the top of both detection chambers 23 so that the two detection chambers 23 move together as a whole. The cross-sectional shape of the detection chamber 23 on the horizontal plane is fan-shaped, and the area of ​​the inner cylinder 211 other than the detection chambers 23 is hollow, allowing the dried raw material to fall through the inner cylinder 211. In other embodiments of this application, the number of detection chambers 23 can be increased according to the actual situation, thereby increasing the amount of raw material sampled and improving the accuracy of detection, but the detection chambers 23 are still circumferentially spaced.

[0041] Each testing chamber 23 has a sampling port 232 on its top wall. The distance between the sampling port 232 on each testing chamber 23 and the central axis of the collecting cylinder 21 is different, meaning that the sampling ports 232 on the two testing chambers 23 are located at different radii on the collecting cylinder 21, allowing the two testing chambers 23 to sample the raw material at different radii through the inner cylinder 211. Each testing chamber 23 also has an outlet 233 at its bottom. To facilitate the final fall of the material from the outlet 233, the bottom wall of the testing chamber 23 can preferably be designed as a shallow and gradually tapering cone, so that only a small amount of raw material needs to fill the bottom wall of the testing chamber 23. A small electric cylinder (not shown) can also be fixed to the bottom surface of the testing chamber 23. A baffle is fixed to the output shaft of the electric cylinder. Under normal circumstances, the baffle is close to the outlet 233 of the testing chamber 23, which can block the outlet 233. When it is necessary to unload the material, the electric cylinder drives the baffle to move and open the outlet 233.

[0042] Along the radial direction of the collection cylinder 21 and gradually approaching the axis, the top walls of both detection chambers 23 are inclined downwards to facilitate the falling of the raw material along the top walls of the detection chambers 23. Each detection chamber 23 has multiple spaced-apart dispersing columns 234 fixed on its inclined top wall, each column perpendicular to the plane of the top wall. When the detection chamber 23 vibrates with the vibrating ring 231, the dispersing columns 234 also vibrate up and down with the detection chamber 23. The falling raw material continuously impacts the vibrating dispersing columns 234, which can break up any clumps of raw material that have formed after drying. A detection instrument 5 is fixed to the top of the detection chamber 23 and its inclined inner wall. The detection instrument 5 is preferably a near-infrared spectrometer. Near-infrared spectrometers utilize the characteristic absorption peaks of the OH bonds in water molecules in the near-infrared region. By emitting near-infrared light onto the raw material sample and analyzing its absorption pattern, the moisture content in the sample can be determined, thus completing the detection of the dryness of the raw material. The application of near-infrared spectroscopy for moisture detection is widely used in actual industrial production and will not be elaborated further here.

[0043] Furthermore, each testing chamber 23 is equipped with a sealing cover 235 at the sampling port 232. The sealing cover 235 is connected to the testing chamber 23 via an elastic connector 236, which can preferably be a tension spring. Under normal circumstances, the sealing block covers the sampling port 232 to seal it. When the testing chamber 23 vibrates, the sealing cover 235 will vibrate along with the testing chamber 23. During vibration, the sealing cover 235 will open the sampling port 232 at intervals, allowing the raw material to fall into the testing chamber 23 from the intermittently opened sampling port 232, thus completing the sampling operation. When sampling is required at the sampling port 232 in the early stage, the output shaft of the auxiliary vibrating component 4 can be extended to a large extent by controlling the external control unit. In this way, the vibrating ball 41 can be closely attached to the vibrating ring 231, and the frequency and force of the impact of the vibrating ball 41 on the vibrating ring 231 are both large. The sealing cover 235 can be smoothly detached from the detection chamber 23, realizing the intermittent opening for collection of raw materials. After sampling is completed, the output shaft of the auxiliary vibrating component 4 can be extended to a smaller extent by controlling the external control unit. The impact force and frequency of the vibrating ball 41 on the vibrating ring 231 are reduced. At this time, the vibration amplitude of the detection chamber 23 and the sealing block are reduced. The sealing cover 235 remains in contact with the detection chamber 23 under the restoring force of the elastic connector 236. The sampling port 232 is closed by the sealing block. At this time, no sampling is performed. The vibration only flattens the raw materials in the detection chamber 23, which is convenient for subsequent testing.

[0044] Furthermore, in other embodiments of this application, multiple sampling ports 232 can be simultaneously opened on the same testing chamber 23, and the sampling ports 232 on the same testing chamber 23 are located at different radii of the inner cylinder 211. At the same time, the sampling ports 232 of different testing chambers 23 are located at different radii, so that the sampling ports 232 can sample materials at different radii. In addition, the testing chamber 23 rotates and samples simultaneously, and can also sample raw materials passing through different positions and radii of the inner cylinder 211, which greatly increases the randomness of sampling, improves the accuracy of subsequent testing, and helps to comprehensively test the dryness of materials. Moreover, the entire sampling and testing operation is carried out simultaneously during the feeding process, thereby realizing online sampling and online testing and reducing the impact on the production progress of raw materials.

[0045] By installing a sealing cover 235 on the top wall of each detection chamber 23, and elastically connecting the sealing cover 235 to the top wall of the detection chamber 23 via an elastic connector 236, and simultaneously installing an auxiliary vibrating element 4 at the end of the receiving plate, when the detection chamber 23 needs to vibrate, the output shaft of the auxiliary vibrating element 4 extends, allowing the vibrating ball 41 at its end to vibrate and contact the vibrating ring 231 at the top of the detection chamber 23. The vibrating ball 41 continuously vibrates and impacts the vibrating ring 231, causing the detection chamber 23 to also vibrate. At this time, the sealing cover 235 will also vibrate accordingly. The elastic connection of the connecting piece 236 ensures that the sealing cover 235 remains connected to the detection chamber 23 during vibration. Furthermore, the sealing cover 235 continuously disengages from and seals the sampling port 232 during vibration, allowing the sampling port 232 to switch between open and closed states. The raw material can enter the detection chamber 23 during the opening and closing of the sampling port 232, completing the material sampling. Simultaneously, as the detection chamber 23 vibrates up and down, it also vibrates and flattens the collected material inside, facilitating subsequent testing and effectively improving the accuracy of the test.

[0046] The implementation principle of the drying device for the production of roxithromycin raw material in this application embodiment is as follows: The vibrating support plate 13 drives the detection chamber 23 to rotate unidirectionally at intervals through the cooperation of the drive gear 133, rack 134, ratchet 31 assembly and a pair of bevel gears. The rotating detection chamber 23 can sample the raw material at different positions in the inner cylinder 211. When the vibrating ball 41 contacts the vibrating ring 231, the detection chamber 23 vibrates up and down, so that the detection chamber 23 can vibrate while rotating to sample. At this time, the sealing block also vibrates. The vibrating sealing block opens the sampling port 232 at intervals, completing the sampling and vibration flattening of the raw material, which is convenient for subsequent testing. The sampling ports 232 on the two detection chambers 23 are located at different radii of the collection cylinder 21, so that the two detection chambers 23 can sample the raw material at different radii in the inner cylinder 211, thereby realizing the sampling of raw materials at different radii and positions in the inner cylinder 211, which greatly improves the randomness of sampling and makes the sampling more comprehensive.

[0047] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A drying apparatus for the production of roxithromycin raw material, characterized in that: include The drying section (1) is hollow inside and used to dry the raw materials. The drying section (1) has an inlet (11) and a outlet (12) at both ends, and is equipped with a support plate (13) that can vibrate up and down and is placed horizontally inside, which is used to evenly distribute the airflow used to dry the raw materials. The detection unit (2) includes a collection cylinder (21) that rotates relative to the drying unit (1) and the axis of rotation is vertical. The collection cylinder (21) is connected to the feed port (12) of the drying unit (1) for sampling the raw material. The collection cylinder (21) is equipped with a detection component for detecting the drying status of the sampled raw material. A drive gear (133) and a rack (134) are provided between the support plate (13) and the collection cylinder (21). The drive gear (133) and the rack (134) are both located below the support plate (13). The rack (134) is vertically fixed to the bottom of the support plate (13) and meshes with the drive gear (133). The drive gear (133) is rotatably connected to the drying section (1) and the axis of rotation is horizontal. A first bevel gear (213) and a second bevel gear (214) are provided at the bottom of the collection cylinder (21). The first bevel gear (213) is coaxially arranged with the drive gear (133). The first bevel gear (213) meshes with the second bevel gear (214), and the second bevel gear (214) is coaxially fixed with the collection cylinder (21). A one-way drive assembly (3) is provided between the drive gear (133) and the first bevel gear (213) so that the drive gear (133) drives the first bevel gear (213) to rotate unidirectionally at intervals. The support plate (13) extends outward from one end near the detection part (2) and enters the collection cylinder (21). A vertical auxiliary vibrating element (4) is provided at one end of the support plate (13) near the detection part (2). The auxiliary vibrating element (4) includes an output shaft that can extend and retract vertically. A vibrating ball (41) is provided at the end of the output shaft. A detection chamber (23) is vertically slidably connected inside the collection cylinder (21). A vibrating ring (231) is provided at the top of the detection chamber (23). The vibrating ring (231) extends horizontally outward from the collection cylinder (21). The vibrating ball (41) is correspondingly provided above the vibrating ring (231) to transmit the vibration of the support plate (13) to the detection chamber (23). The detection component is correspondingly provided on the inner top wall of each detection chamber (23). Multiple detection chambers (23) are provided and are distributed circumferentially along the axis of the collection cylinder (21). Along the radial direction of the collection cylinder (21), the outer walls of all detection chambers (23) are vertically slidably connected to the inner wall of the collection cylinder (21). The vibration ring (231) is connected to the top of all detection chambers (23) at the same time so that the multiple detection chambers (23) move together as a whole. Each detection chamber (23) has a corresponding sampling port (232) on its top wall. Each sampling port (232) is used to collect and sample materials at different radii in the collection cylinder (21). Each detection chamber (23) has an opening and closing outlet (233) at its bottom. Each of the detection chambers (23) is provided with a sealing cap (235) at the sampling port (232). The sealing cap (235) is connected to the detection chamber (23) through an elastic connector (236). When the detection chamber (23) vibrates, the sealing cap (235) vibrates synchronously with the detection chamber (23) to close or open the sampling port (232). The one-way drive assembly (3) includes a ratchet (31), a turntable (32), a locking tooth (33), and a spring (34). The ratchet (31) is coaxial and rotatably connected to the outer ring of the turntable (32). The inner ring wall of the ratchet (31) is provided with a plurality of spaced inner ring tooth grooves (311) in the circumferential direction. The turntable (32) is coaxially fixed with the drive gear (133). The ratchet (31) is coaxially fixed with the first bevel gear (213). One end of the locking tooth (33) is rotatably connected to the turntable (32). The other end of the locking tooth (33) extends outward and engages in the inner ring tooth groove (311). The end of the locking tooth (33) away from the turntable (32) abuts against one side wall of the ratchet (31) in the inner ring tooth groove (311). The spring (34) is used to keep the locking tooth (33) engaged with the inner ring tooth groove (311) of the ratchet (31).

2. The drying apparatus for producing roxithromycin raw material according to claim 1, characterized in that: Along the radial direction of the collection cylinder (21), the top walls of all the detection chambers (23) are inclined downwards.

3. The drying apparatus for producing roxithromycin raw material according to claim 2, characterized in that: Each of the detection chambers (23) has multiple spaced-apart dispersing columns (234) on its top wall, and each dispersing column (234) is perpendicular to the plane of the top wall.

4. The drying apparatus for producing roxithromycin raw material according to claim 1, characterized in that: The top surface of the bearing plate (13) is provided with multiple rows of guide plates (131). Along the direction from the feed inlet (11) to the discharge outlet (12), the multiple rows of guide plates (131) are distributed at intervals. All guide plates (131) are inclined upward and their tops extend towards the discharge outlet (12).

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