Method and device for determining auxiliary material microcrystalline cellulose in lecithin tablet

Abstract

The invention discloses a method and a device for measuring microcrystalline cellulose serving as an auxiliary material in a lecithin tablet, belongs to the field of detection equipment, and can solve the problems that in an existing detection mode, viscosity of lecithin easily causes particle aggregation and influences the measurement accuracy, the operation is tedious, time-consuming and labor-consuming during pretreatment, the number of procedures is large during detection, and the detection efficiency is low in the prior art. Multiple sample transfer is needed, manual intervention links are many, and the detection stability is influenced. The method comprises the steps that S1, a pull rod is pulled upwards to drive a sliding plate to slide upwards, and lecithin pieces are put into a smashing box through a feeding port; s2, electrifying a driving motor I to drive a crushing cutter to rotate so as to crush the lecithin sheets; s3, the spiral blade rotates to drive the lecithin powder to move downwards and fall into the surfactant; and S4, opening a valve, enabling the lecithin mixed surfactant to flow out through a discharging pipe and fall on the filter paper, and electrifying a driving motor II to slick lecithin powder on the filter paper.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of detection, and particularly relates to a method and device for determining microcrystalline cellulose as an auxiliary material in lecithin tablets. BACKGROUND

[0002] Microcrystalline cellulose is a key auxiliary material for lecithin tablets, and the quality of the microcrystalline cellulose directly affects the tabletability, disintegrability and drug release characteristics of the tablets. Therefore, the content of the microcrystalline cellulose needs to be detected in the lecithin tablets. In the existing detection method, the viscosity of lecithin easily leads to particle agglomeration, which affects the accuracy of the determination. Meanwhile, the pretreatment operation is complicated, time-consuming and laborious, and the detection process is complicated, the sample needs to be transferred for multiple times, manual intervention links are many, and the stability of the detection is affected. SUMMARY

[0003] The application aims to solve the above problems in the prior art, and provides a method and device for determining microcrystalline cellulose as an auxiliary material in lecithin tablets.

[0004] To achieve the above object, the application adopts the following technical scheme:

[0005] A device for determining microcrystalline cellulose as an auxiliary material in lecithin tablets comprises a crushing device, a mixing device and a bearing device, the crushing device is slidably connected with the mixing device, the crushing device penetrates into the mixing device, and the bearing device is detachably connected with the mixing device.

[0006] The pulverizing device includes a pulverizing box, a feeding port, a filter plate, a rotating shaft, spring one, a driving motor one, a sliding plate, a pull rod, a limiting plate one, a pulverizing knife, a discharge pipe, a spiral blade, a stirring paddle, a fixing frame, a spring baffle and spring two, the pulverizing box is provided with the feeding port on the side surface, the bottom surface of the pulverizing box is provided with the filter plate, the lower end of the rotating shaft rotates through the top surface of the pulverizing box and the filter plate, spring one is sleeved on the rotating shaft, the driving motor one is fixed on the top surface of the pulverizing box, the output shaft of the driving motor one is fixedly connected with the upper end of the rotating shaft, the sliding plate is slidably connected with the rotating shaft, the bottom surface of the sliding plate is conical, the spring one is arranged between the sliding plate and the inner top surface of the pulverizing box, the sliding plate is slidably connected with the inner wall of the pulverizing box, one end of the pull rod slides through the top surface of the pulverizing box and is fixedly connected with the sliding plate, the rotating shaft is provided with the limiting plate one, the rotating shaft is fixedly provided with the pulverizing knife, the limiting plate one is located above the pulverizing knife, the lower end of the pulverizing box is provided with the discharge pipe, the lower end of the rotating shaft is rotatably connected with the inner wall of the discharge pipe through a shaft support, the rotating shaft is fixedly provided with the spiral blade, the spiral blade is slidably connected with the inner wall of the discharge pipe, the lower end of the rotating shaft is fixedly provided with the stirring paddle, the lower end of the discharge pipe is provided with an opening, the stirring paddle is arranged below the opening, the fixing frames are fixedly arranged on the both side surfaces of the pulverizing box, the spring baffle is arranged on each of the fixing frames, and two spring two are sleeved on each of the fixing frames.

[0007] The mixing device includes a mixing barrel, lugs, a vibration unit, a discharge pipe, a dispersion unit and a support frame, the upper end of the mixing barrel is provided with an upward opening, the both sides of the mixing barrel are symmetrically provided with lugs, the lugs are slidably connected with the fixing frame and are arranged between the two spring two, the discharge pipe penetrates into the mixing barrel, the vibration unit is fixedly arranged on the side wall of the mixing barrel, the lower end of the mixing barrel is provided with the discharge pipe, the valve is arranged on the discharge pipe, the dispersion unit is fixedly arranged on the lower end of the discharge pipe, and the support frame is fixedly arranged on the outer wall of the mixing barrel.

[0008] The dispersion unit includes a driving motor two, a sliding shaft, a sliding shaft baffle, spring three, a sliding sleeve and a scraper, the driving motor two is fixedly arranged on the lower end of the discharge pipe, the sliding shaft is fixedly arranged on the output shaft of the driving motor two, the sliding shaft baffle is fixedly arranged on the lower end of the sliding shaft, spring three is sleeved on the sliding shaft, the sliding shaft is provided with a long key along the length direction, the sliding sleeve is limitingly and slidably connected with the sliding shaft through the long key, and a plurality of scrapers are fixedly arranged on the side surface of the sliding sleeve.

[0009] The bearing device includes a bearing disc, a bearing disc groove, filter holes, a cavity and a water outlet, the support frame is provided with guide columns, the bearing disc slides into the guide columns, the top surface of the bearing disc is provided with the bearing disc groove, the bottom surface of the bearing disc groove is provided with a plurality of filter holes, the inside of the bearing disc is provided with a cavity, and the bottom surface of the bearing disc is provided with a water outlet.

[0010] A method for using a device for measuring microcrystalline cellulose as an excipient in lecithin tablets, the method comprising the following steps:

[0011] S1: pull the pull rod upwards to drive the sliding plate upwards, and put the lecithin tablet into the crushing box through the feeding port;

[0012] S2: power on the driving motor to drive the crushing knife to rotate and crush the lecithin tablet;

[0013] S3: the spiral blade rotates to drive the lecithin powder to move downwards and fall into the surfactant;

[0014] S4: open the valve, the lecithin mixed with the surfactant flows out through the discharge pipe and falls on the filter paper, and power on the driving motor two to scrape the lecithin powder on the filter paper flat.

[0015] Compared with the prior art, the beneficial effects of the present application are:

[0016] The present application provides a device for measuring microcrystalline cellulose as an excipient in lecithin tablets, which can solve the problems of particle agglomeration caused by the stickiness of lecithin in the existing detection method, affecting the accuracy of the measurement, and the problems of complicated and time-consuming operation during pretreatment, multiple processes during detection, multiple sample transfers, multiple manual intervention links, and affecting the stability of the detection. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a whole structure top view;

[0018] Figure 2 is a crushing device structure schematic diagram;

[0019] Figure 3 is a mixing device structure schematic diagram;

[0020] Figure 4 is a dispersion unit structure schematic diagram;

[0021] Figure 5 is a bearing device structure schematic diagram. DETAILED DESCRIPTION

[0022] The technical solutions in the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0023] A device for measuring the auxiliary material microcrystalline cellulose in lecithin tablets, comprising: a crushing device 1, a mixing device 2 and a bearing device 3, the crushing device 1 is slidably connected with the mixing device 2, the crushing device 1 penetrates into the mixing device 2, and the bearing device 3 is detachably connected with the mixing device 2.

[0024] The crushing device 1 comprises a crushing box 1-1, a feeding port 1-2, a filter plate 1-3, a rotating shaft 1-4, a spring 1-5, a driving motor 1-6, a sliding plate 1-7, a pull rod 1-8, a limiting plate 1-9, a crushing knife 1-10, a discharge pipe 1-11, a spiral blade 1-12, a stirring paddle 1-13, a fixed frame 1-14, a spring baffle 1-15 and a spring 2 1-16, the crushing box 1-1 is provided with a feeding port 1-2 on the side surface, the bottom surface of the crushing box 1-1 is provided with a filter plate 1-3, the lower end of the rotating shaft 1-4 penetrates through the top surface of the crushing box 1-1 and the filter plate 1-3, the spring 1-5 is sleeved on the upper end of the rotating shaft 1-4, the driving motor 1-6 is fixed on the top surface of the crushing box 1-1, the output shaft of the driving motor 1-6 is fixedly connected with the upper end of the rotating shaft 1-4, the sliding plate 1-7 is slidably connected with the rotating shaft 1-4, the bottom surface of the sliding plate 1-7 is tapered, the spring 1-5 is arranged between the sliding plate 1-7 and the inner top surface of the crushing box 1-1, the sliding plate 1-7 is slidably connected with the inner wall of the crushing box 1-1, one end of the pull rod 1-8 penetrates through the top surface of the crushing box 1-1 and is fixedly connected with the sliding plate 1-7, the limiting plate 1-9 is arranged on the rotating shaft 1-4, the crushing knife 1-10 is fixed on the rotating shaft 1-4, the limiting plate 1-9 is located above the crushing knife 1-10, the discharge pipe 1-11 is arranged at the lower end of the crushing box 1-1, the lower end of the rotating shaft 1-4 is rotatably connected with the inner wall of the discharge pipe 1-11 through a shaft support, the spiral blade 1-12 is fixed on the rotating shaft 1-4, the spiral blade 1-12 is slidably connected with the inner wall of the discharge pipe 1-11, the stirring paddle 1-13 is fixed on the lower end of the rotating shaft 1-4, the lower end of the discharge pipe 1-11 is provided with an opening, the stirring paddle 1-13 is arranged below the opening, the fixed frames 1-14 are fixed on the two side surfaces of the crushing box 1-1, the spring baffle 1-15 is arranged on each fixed frame 1-14, and two spring 2 1-16 are sleeved on each fixed frame 1-14.

[0025] The mixing device 2 comprises a mixing barrel 2-1, lugs 2-2, a vibration unit 2-3, a discharge pipe 2-4, a dispersion unit 2-5 and a support frame 2-6, the mixing barrel 2-1 is provided with an upward opening at the upper end, the mixing barrel 2-1 is symmetrically provided with lugs 2-2 on both sides, the lugs 2-2 are slidably connected with the fixed frame 1-14 and are arranged between the two spring twos 1-16, the discharge pipe 1-11 penetrates into the mixing barrel 2-1, the vibration unit 2-3 is fixed on the side wall of the mixing barrel 2-1, the discharge pipe 2-4 is arranged at the lower end of the mixing barrel 2-1, the discharge pipe 2-4 is provided with a valve, the dispersion unit 2-5 is fixed at the lower end of the discharge pipe 2-4, and the support frame 2-6 is fixed on the outer wall of the mixing barrel 2-1.

[0026] The dispersion unit 2-5 comprises a drive motor two 2-5-1, a sliding shaft 2-5-2, a sliding shaft baffle 2-5-3, a spring three 2-5-4, a sliding sleeve 2-5-5 and a scraper 2-5-6, the drive motor two 2-5-1 is fixed at the lower end of the discharge pipe 2-4, the output shaft of the drive motor two 2-5-1 is fixed with the sliding shaft 2-5-2, the lower end of the sliding shaft 2-5-2 is fixed with the sliding shaft baffle 2-5-3, the sliding shaft 2-5-2 is sleeved with the spring three 2-5-4, the sliding shaft 2-5-2 is provided with a long key along the length direction, the sliding sleeve 2-5-5 is limitingly and slidably connected with the sliding shaft 2-5-2 through the long key, and a plurality of scrapers 2-5-6 are uniformly fixed on the side surface of the sliding sleeve 2-5-5.

[0027] The bearing device 3 comprises a bearing disc 3-1, a bearing disc groove 3-2, a filter hole 3-3, a cavity 3-4 and a water outlet 3-5, a guide column is arranged on the support frame 2-6, the bearing disc 3-1 slides into the guide column, the top surface of the bearing disc 3-1 is provided with the bearing disc groove 3-2, the bottom surface of the bearing disc groove 3-2 is provided with a plurality of filter holes 3-3, the inside of the bearing disc 3-1 is provided with the cavity 3-4, and the bottom surface of the bearing disc 3-1 is provided with the water outlet 3-5.

[0028] Further, the vibration unit 2-3 comprises a drive motor three and an eccentric disc, the drive motor three is fixed on the side wall of the mixing barrel 2-1, and the output shaft of the drive motor three is fixed with the eccentric disc.

[0029] Further, the limiting plate one 1-9 can avoid the sliding plate 1-7 from being damaged by the impact of the crushing knife 1-10.

[0030] A method for using a device for measuring microcrystalline cellulose as an auxiliary material in lecithin tablets, the method comprising the following steps:

[0031] S1: pull up the pull rod 1-8 to drive the sliding plate 1-7 to slide upward, and put the lecithin tablets into the crushing box 1-1 through the feeding port 1-2;

[0032] S2: power on the driving motor one 1-6 to drive the crushing knife 1-10 to rotate and crush the lecithin tablets;

[0033] S3: the spiral blade 1-12 rotates to drive the lecithin powder to move downward and fall into the surfactant;

[0034] S4: open the valve, and the lecithin mixed with the surfactant flows out through the discharge pipe 2-4 and falls on the filter paper; power on the driving motor two 2-5-1 to scrape the lecithin powder on the filter paper flat.

[0035] The working principle of the present application is:

[0036] The device is connected with external power supply, when using, pull up the pull rod 1-8 to drive the sliding plate 1-7 to slide up along the rotating shaft 1-4, at the same time, compress the spring one 1-5, when the sliding plate 1-7 is above the feeding port 1-2, put the lecithin tablet into the crushing box 1-1 through the feeding port 1-2, then release the pull rod 1-8, drive the sliding plate 1-7 to reset through the spring one 1-5, the sliding plate 1-7 press on the lecithin tablet, power on the driving motor one 1-6, drive the crushing knife 1-10 to rotate through the rotating shaft 1-4 to crush the lecithin tablet, the sliding plate 1-7 can avoid the crushed lecithin tablet to splash randomly, make the lecithin tablet always in the crushing range of the crushing knife 1-10 to increase the crushing speed, at the same time, the bottom surface of the sliding plate 1-7 is conical to extrude the lecithin tablet to the surrounding, which is convenient for the crushing of the crushing knife 1-10, after the crushed lecithin is filtered through the filter plate 1-3, the lecithin powder with the right particle size falls on the spiral blade 1-12, the spiral blade 1-12 rotates through the rotating shaft 1-4 to drive the lecithin powder at the upper end to move downwards, the conveying mode of the spiral blade 1-12 can avoid the lecithin powder to fall in the surfactant too much at one time to cause the agglomeration, pour the surfactant into the mixing barrel 2-1, the lecithin powder falls in the surfactant through the spiral blade 1-12, rotate the stirring paddle 1-13 through the rotating shaft 1-4, when the lecithin powder slides out of the discharge pipe 1-11, directly rotate the stirring paddle 1-13 to disperse in the surfactant, which can further avoid the agglomeration, at the same time, the stirring paddle 1-13 rotates to stir the surfactant in the mixing barrel 2-1, which can make the lecithin powder and the surfactant fully contact, power on the vibration unit 2-3 to generate vibration, the vibration is transmitted to the surfactant in the mixing barrel 2-1 to further accelerate the reaction of the lecithin powder and the surfactant, through the lug 2-2, the fixing frame 1-14 and the spring two 1-16, the vibration generated by the vibration unit 2-3 can be offset to avoid the resonance phenomenon, place the filter paper in the bearing disc groove 3-2 in advance, after the reaction of the lecithin powder and the surfactant is completed, open the valve, the lecithin mixed with the surfactant flows out through the discharge pipe 2-4, falls on the filter paper, then close the valve, filter the surfactant through the filter hole 3-3 to flow into the cavity 3-4 to collect, which can also be discharged through the water outlet 3-5, then power on the driving motor two 2-5-1 to drive the sliding sleeve 2-5-5 to rotate through the sliding shaft 2-5-2, the sliding sleeve 2-5-5 drives the scraper 2-5-6 to rotate, scrape the lecithin powder on the filter paper, then pull up the sliding sleeve 2-5-5 to separate the scraper 2-5-6 from the filter paper, then take down the bearing disc 3-1 to replace the new bearing disc 3-1, or take out the filter paper alone to replace the new filter paper, then release the sliding sleeve 2-5-5, drive the sliding sleeve 2-5-5 to reset through the spring three 2-5-4, and make the scraper 2-5-6 press on the filter paper again.Then the discharge pipe 2-4 valve is opened, the above steps can be repeated to make the next sample, by the above-mentioned manner can solve some detection mode, lecithin viscosity is easy to cause particle agglomeration, affect the accuracy of the problem, and in the pretreatment when the operation is complicated, time-consuming and laborious, in the detection process, need to transfer the sample many times, manual intervention link is much, affect the stability of the problem of detection.

[0037] It will be apparent to those skilled in the art that the application is not limited to the details of the above-exemplified embodiments and that the present application can be implemented in other forms without departing from the spirit or essential characteristics of the present application. The presently disclosed embodiments are therefore considered in all respects to be illustrative and not restrictive, the scope of the application being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalents are intended to be embraced therein. No feature of the application is to be construed as limiting the scope of the claims to its exact counterpart.

[0038] Furthermore, it should be understood that although the description herein is made on the basis of the embodiments, not every embodiment contains only one independent technical solution, and the description herein is made in this way only for the sake of clarity, and those skilled in the art should consider the description as a whole, and the technical solutions in each embodiment can also be properly combined to form other embodiments which can be understood by those skilled in the art.

Claims

1. A device for measuring the content of microcrystalline cellulose as an auxiliary material in lecithin tablets, characterized in that: include: A crushing device (1), a mixing device (2) and a carrying device (3), wherein the crushing device (1) is slidably connected to the mixing device (2), the crushing device (1) penetrates into the mixing device (2), and the carrying device (3) is detachably connected to the mixing device (2).

2. A device for measuring the auxiliary material microcrystalline cellulose in lecithin tablets according to claim 1, characterized in that: The pulverizing device (1) comprises: a pulverizing box (1-1), a feed port (1-2), a filter plate (1-3), a rotating shaft (1-4), a spring (1-5), a driving motor (1-6), a sliding plate (1-7), a pull rod (1-8), a limit plate (1-9), a pulverizing knife (1-10), a discharge pipe (1-11), a spiral blade (1-12), a stirring paddle (1-13), a fixing frame (1-14), a spring baffle (1-15) and a spring (1-16). The pulverizing box (1-1) is provided with a feed port (1-2) on the side thereof, and a bottom surface of the pulverizing box (1-1) is provided with a A filter plate (1-3) is provided, the lower end of the rotating shaft (1-4) rotates through the top surface of the crushing box (1-1) and the filter plate (1-3), a spring (1-5) is sleeved on the rotating shaft (1-4), a driving motor (1-6) is fixed to the top surface of the crushing box (1-1), an output shaft of the driving motor (1-6) is fixedly connected to the upper end of the rotating shaft (1-4), the sliding plate (1-7) is slidably connected to the rotating shaft (1-4), the bottom surface of the sliding plate (1-7) is set to be conical, and the spring (1-5) is set between the sliding plate (1-7) and the top surface of the crushing box (1-1). The side surface of the sliding plate (1-7) is slidably connected to the inner wall of the crushing box (1-1), one end of the pull rod (1-8) slides through the top surface of the crushing box (1-1) and is fixedly connected to the sliding plate (1-7), a limiting plate (1-9) is provided on the rotating shaft (1-4), a crushing knife (1-10) is fixed on the rotating shaft (1-4), and the limiting plate (1-9) is located above the crushing knife (1-10), a discharge pipe (1-11) is provided at the lower end of the crushing box (1-1), and the lower end of the rotating shaft (1-4) is rotatably connected to the inner wall of the discharge pipe (1-11) through a shaft bracket, A spiral blade (1-12) is fixed on the rotating shaft (1-4), and the spiral blade (1-12) is slidably connected to the inner wall of the discharge pipe (1-11). A stirring paddle (1-13) is fixed to the lower end of the rotating shaft (1-4), and an opening is provided at the lower end of the discharge pipe (1-11). The stirring paddle (1-13) is arranged below the opening. Fixed frames (1-14) are symmetrically fixed on both sides of the crushing box (1-1), and spring baffles (1-15) are provided on the two fixed frames (1-14). Each of the fixed frames (1-14) is equipped with two springs 2 (1-16).

3. A device for measuring the auxiliary material microcrystalline cellulose in lecithin tablets according to claim 2, characterized in that: The mixing device (2) comprises: a mixing barrel (2-1), a lug (2-2), a vibration unit (2-3), a discharge pipe (2-4), a dispersion unit (2-5) and a support frame (2-6); the upper end of the mixing barrel (2-1) is provided with an upward opening; lugs (2-2) are symmetrically provided on both sides of the mixing barrel (2-1); the lugs (2-2) are slidably connected to the fixing frame (1-14) and are provided between the two springs (1-16); the discharge pipe (1-11) penetrates into the mixing barrel (2-1); the vibration unit (2-3) is fixed to the side wall of the mixing barrel (2-1); the lower end of the mixing barrel (2-1) is provided with a discharge pipe (2-4); the discharge pipe (2-4) is provided with a valve; the lower end of the discharge pipe (2-4) is fixed with the dispersion unit (2-5); and the outer wall of the mixing barrel (2-1) is fixed with a support frame (2-6).

4. A device for measuring the auxiliary material microcrystalline cellulose in lecithin tablets according to claim 3, characterized in that: The dispersion unit (2-5) comprises: a second drive motor (2-5-1), a sliding shaft (2-5-2), a sliding shaft baffle (2-5-3), a third spring (2-5-4), a sliding sleeve (2-5-5) and a scraper (2-5-6); the second drive motor (2-5-1) is fixed to the lower end of the discharge pipe (2-4); the sliding shaft (2-5-2) is fixed to the output shaft of the second drive motor (2-5-1); the sliding shaft baffle (2-5-3) is fixed to the lower end of the sliding shaft (2-5-2); the third spring (2-5-4) is sleeved on the sliding shaft (2-5-2); the sliding shaft (2-5-2) is provided with a long key along its length direction; the sliding sleeve (2-5-5) is connected to the sliding shaft (2-5-2) in a limited sliding manner via the long key; and a plurality of scrapers (2-5-6) are evenly distributed and fixed on the side of the sliding sleeve (2-5-5).

5. A device for measuring the auxiliary material microcrystalline cellulose in lecithin tablets according to claim 4, characterized in that: The carrying device (3) comprises: a carrying plate (3-1), a carrying plate groove (3-2), a filter hole (3-3), a cavity (3-4) and a water outlet (3-5); a guide column is provided on the support frame (2-6); the carrying plate (3-1) slides into the guide column; a carrying plate groove (3-2) is provided on the top surface of the carrying plate (3-1); a plurality of filter holes (3-3) are provided on the bottom surface of the carrying plate groove (3-2); a cavity (3-4) is provided inside the carrying plate (3-1); and a water outlet (3-5) is provided on the bottom surface of the carrying plate (3-1).

6. A method for using the device for determining the amount of microcrystalline cellulose as an auxiliary material in lecithin tablets according to claim 5, characterized in that: The method comprises the following steps: S1: Pull the pull rod (1-8) upward to drive the sliding plate (1-7) to slide upward, and put the lecithin tablets into the crushing box (1-1) through the feeding port (1-2); S2: energizing the driving motor 1 (1-6) to drive the crushing blade (1-10) to rotate and crush the lecithin flakes; S3: The spiral blades (1-12) rotate to drive the lecithin powder downward and fall into the surfactant; S4: Open the valve and the lecithin mixed surfactant flows out through the discharge pipe (2-4) and falls on the filter paper. Turn on the driving motor 2 (2-5-1) to scrape the lecithin powder on the filter paper.

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