Polygonum cuspidatum four-huang phlebitis patch and manufacturing and using method thereof

Abstract

The invention relates to a polygonum cuspidatum four-huang phlebitis patch which comprises an external dressing, a towel pad and an auxiliary heating type external package. The outer dressing comprises an upper patch, a lower patch and an inner core; the upper sticking cloth and the lower sticking cloth are adhesive tape stickers, and the inner core is arranged between the upper sticking cloth and the lower sticking cloth; the inner core is made of traditional Chinese medicine paste, and the inner core is divided into a summer and autumn type and a winter and spring type. According to the polygonum cuspidatum, sihuang and phlebitis patch, the occurrence rate of phlebitis caused by sodium aescinate injection is remarkably reduced; the polygonum cuspidatum four-huang phlebitis patch is good in using effect and convenient to heat in use, extra heating materials do not need to be prepared for preheating, preheating can be carried out until the temperature-sensing color-changing coating changes color, and the polygonum cuspidatum four-huang phlebitis patch is faster, more convenient and more accurate.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medicine, in particular to a rhizoma polygoni cuspidati four Huang phlebitis patch and its preparation and use method. BACKGROUND

[0002] In traditional Chinese medicine, phlebitis belongs to "pulse numbness" and "evil pulse". It is proposed that the pathogenesis of phlebitis is related to puncture and drug damage to local blood vessels. Wet and hot and blood stasis are stagnated in blood vessels, causing local blood vessels to be unsmooth, and thus causing the disease. For example, "Sheng Ji Zong Lun" records: "The disease of evil pulse, its appearance is red and suddenly rises, and gathers, like the appearance of dead earthworms, and like water in the pulse, long and short with the birth of collaterals, get in the collaterals and do not disperse, then the blood vessels are stasis and become the disease, long-term treatment, then the stasis of the pulse changes into the disease". The evil toxin of damp heat stagnates in the meridians, causing the blood to be unsmooth in the local collaterals, and local fever, redness, swelling, pain and other symptoms often occur. Because the evil toxin of damp heat stagnates in the meridians, the blood circulation is blocked, and the pathological changes of blood stasis and blood stasis are further caused. Because the blood is unsmooth, the blood is condensed on the skin, and the transportation of body fluid is blocked, further aggravating the pathological changes of the evil toxin of damp heat. Therefore, the basic principle of traditional Chinese medicine in treating phlebitis is "activating blood and resolving stasis, clearing heat and resolving toxin, removing dampness and swelling" and the like, and certain effect has been achieved.

[0003] Sodium aescinate is a traditional Chinese medicine injection, which has the effects of anti-inflammatory, anti-exudation, improving microcirculation, detumescence and anti-oxygen free radical, and is often used for the treatment of limb swelling after trauma or operation. More than 80% of patients will have different degrees of phlebitis symptoms after 3-5 days of injection of sodium aescinate, which affects the medication compliance and disease treatment. By checking the drug instruction, it is found that the adverse reactions of the drug are more pain and swelling. By consulting the literature: the PH value of sodium aescinate is 4.6, which is significantly lower than the normal value of human body. When the PH is 4.5, it is easy to induce phlebitis. Sodium aescinate is an extract from plants, which belongs to traditional Chinese medicine preparation. The drug itself and the microparticles in the drug stimulate the blood vessels, causing phlebitis, even thrombosis phlebitis.

[0004] Current situation of prevention or intervention of phlebitis:

[0005] (1) 50% magnesium sulfate wet dressing: traditionally, 50% magnesium sulfate wet dressing is often used after the occurrence of phlebitis, which can improve the blood circulation of the exudation part and reduce the inflammatory reaction, has certain curative effect and low price. Clinical findings: magnesium sulfate crystals are precipitated after evaporation of water, the gauze is dry and hard, and it is difficult to contact the skin, which affects the absorption of the drug. If the wet dressing time exceeds 1 hour, the skin at the wet dressing site will be white, and the patient will be uncomfortable, which affects the application compliance.

[0006] (2) External application of ointments: Ruyi Huangjin Powder, Yunnan Baiyao, Sanhuang Ointment, Fuhuang Ointment, Huzhang Ointment, and Osteitis Ointment are all effective for phlebitis. The price is high: MEBO Burn Moisturizing Ointment is 75.6 yuan (40 mg), Fuhuang Ointment is 15 yuan (20 mg), Huzhang Ointment (internal preparation) is 48 yuan / tube, and Sanhuang Ointment is 58 yuan (40 mg). The production process is complicated. The dosage is large, and it is impossible to observe whether the local skin has extravasation after application. Time: Applying the medicine and scrubbing takes the nurse a long time, about 3 minutes. It is suitable for a small number of patients. It is used for prevention in wards with large infusion volumes and is inconvenient to promote.

[0007] In addition, existing intravenous patches need to be heated in a water bath before use. They must be wiped dry and hot water must be prepared before use. The heating time and degree are difficult to control, making them very inconvenient to use. If heating conditions are lacking, the effectiveness of use will be compromised.

[0008] Therefore, the Polygonum cuspidatum phlebitis patch was designed to solve the above problems. Summary of the Invention

[0009] In order to overcome the above shortcomings, the present invention provides a Polygonum cuspidatum and Four Yellow Phlebitis Patch, comprising an external dressing, a towel pad and an auxiliary heating outer packaging;

[0010] The outer dressing comprises an upper patch, a lower patch and an inner core; the upper patch and the lower patch are adhesive tapes, and the inner core is placed between the upper patch and the lower patch;

[0011] The inner core is a traditional Chinese medicine ointment, which is divided into two types: summer and autumn and winter and spring;

[0012] The summer and autumn style inner core is composed of the following raw materials in parts by weight:

[0013] 8 parts of Polygonum cuspidatum, 6 parts of Rhubarb, 6 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 6 parts of Phellodendron amurense, 1 part of Menthol, 1 part of Borneolum Syntheticum, 3 parts of Sesame Oil and 3 parts of Honey;

[0014] The winter and spring style inner core is composed of the following raw materials in parts by weight:

[0015] 8 parts of Polygonum cuspidatum, 6 parts of Rhubarb, 6 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 6 parts of Phellodendron amurense, 1 part of Angelica dahurica, 1 part of Notopterygium wilfordii, 3 parts of sesame oil and 3 parts of honey;

[0016] The towel pad is used to pad under the limbs;

[0017] The external dressing is contained in the auxiliary heating outer packaging.

[0018] Preferably, the auxiliary heating outer package comprises a layered outer package bag, which is divided into an upper space and a lower space, a heating pad is arranged in the upper space, and the external application material is arranged in the lower space; an opening is arranged in the middle of the upper surface of the upper space, and the opening is externally sealed by a tearable adhesive seal; a Celsius color-changing heat-sensitive sticker is arranged in the middle of the lower surface of the lower space; and one end of the layered outer package bag 1 is provided with a tearable opening.

[0019] Preferably, the heating pad is a paper bag containing a heating material.

[0020] Preferably, the heating material comprises iron powder, activated carbon, vermiculite, water and salt, and the heating principle is to generate heat by using the heat release of iron oxidation reaction.

[0021] Preferably, the color-changing heat-sensitive sticker is a reversible color-changing heat-sensitive sticker.

[0022] Preferably, the size of the inner core is 7*10 cm.

[0023] Preferably, the size of the upper and lower adhesive cloths is 12*16 cm.

[0024] Preferably, the manufacturing method of the summer and autumn inner core is as follows: 8 parts of giant knotweed, 6 parts of rhubarb, 6 parts of scurfpea, 6 parts of coptis, 1 part of mint and 1 part of borneol are mixed, crushed and ground; 3 parts of sesame oil and 3 parts of honey are added for preparation into a 7*10 cm summer and autumn inner core.

[0025] Preferably, the manufacturing method of the winter and spring inner core is as follows: 8 parts of giant knotweed, 6 parts of rhubarb, 6 parts of scurfpea, 6 parts of coptis, 1 part of angelica pubescens and 1 part of notopterygium are mixed, crushed and ground; 3 parts of sesame oil and 3 parts of honey are added for preparation into a 7*10 cm winter and spring inner core.

[0026] Preferably, the use method of the giant knotweed four-huang phlebitis patch is as follows: the adhesive seal is torn open, the heating pad in the layered outer package bag contacts the external air to start heating, and the heat is transmitted to the external application material through the layer between the upper space and the lower space to preheat the external application material; when the color-changing heat-sensitive sticker changes color, it indicates that the temperature of the external application material is appropriate, at which time the tearable opening is torn open to take out the external application material; the external application material is covered on the puncture point 3-5 cm above along the vein direction, and a towel is placed under the limb; after external application for half an hour, whether the patient has pain is inquired, whether phlebitis symptoms occur is observed, and whether the medication site is red and swollen is observed.

[0027] The beneficial effects of the present application are as follows:

[0028] The giant knotweed four-huang phlebitis patch significantly reduces the incidence of phlebitis caused by sodium aescinate injection.

[0029] The tiger's claw four yellow phlebitis paste has good use effect, and is convenient to heat, without additional preparation of heating materials for preheating, and can be preheated to color change of the color change heat-sensitive paste, so that the tiger's claw four yellow phlebitis paste is more convenient, faster and more accurate.

[0030] The tiger's claw four yellow phlebitis paste has the effects of activating blood circulation, removing blood stasis, reducing swelling and pain, and detoxifying and resolving nodules, and has good prevention and treatment effects on phlebitis caused by sodium aescinate injection.

[0031] The tiger's claw four yellow phlebitis paste is simple and convenient to manufacture.

[0032] The tiger's claw four yellow phlebitis paste is divided into two kinds of summer and autumn and spring and winter, different medicaments are added according to different seasons, and the use effect is better. BRIEF DESCRIPTION OF DRAWINGS

[0033] Figure 1 Front view of auxiliary heating type outer packaging

[0034] Figure 2 Back view of auxiliary heating type outer packaging

[0035] Figure 3 Sectional view of auxiliary heating type outer packaging

[0036] Figure 4 Sectional view of interlayer type outer packaging bag

[0037] Figure 5 Perspective view of external dressing

[0038] Among them:

[0039] 1-interlayer type outer packaging bag; 14-easy-to-tear opening; 11-upper space; 12-lower space; 13-opening; 2-pasting; 3-color change heat-sensitive paste; 4-warm baby; 5-external dressing; 51-upper cloth; 52-lower cloth; 53-inner core DETAILED DESCRIPTION

[0040] The tiger's claw four yellow phlebitis paste comprises an external dressing 5, a towel pad and an auxiliary heating type outer packaging

[0041] The external dressing 5 comprises an upper cloth 53, a lower cloth 51 and an inner core 52; the upper cloth 53 and the lower cloth 51 are adhesive cloth, and the inner core 52 is arranged between the upper cloth 53 and the lower cloth 51

[0042] The inner core 52 is a traditional Chinese medicine ointment, and the inner core 52 is divided into two kinds of summer and autumn and spring and winter

[0043] The inner core of the summer and autumn kind is composed of the following raw materials in parts by weight:

[0044] Rhizoma Polygoni Cuspidati 8 parts, Radix et Rhizoma Rhei 6 parts, Radix Scutellariae 6 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 6 parts, Herba Menthae 1 part, Borneolum Syntheticum 1 part, Sesami Oil 3 parts and Honey 3 parts;

[0045] The inner core of the winter and spring version is composed of the following raw materials in parts by weight:

[0046] Rhizoma Polygoni Cuspidati 8 parts, Radix et Rhizoma Rhei 6 parts, Radix Scutellariae 6 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 6 parts, Radix Angelicae Pubescentis 1 part, Herba Angelicae Pubescentis 1 part, Sesami Oil 3 parts and Honey 3 parts;

[0047] The towel pad is used to pad under the limbs;

[0048] The external application 5 is packed in the auxiliary heating outer package.

[0049] Preferably, the auxiliary heating outer package comprises a compartmentalized outer package bag 1, which is divided into an upper space 11 and a lower space 12, a heating pad is arranged in the upper space 11, and the external application 5 is arranged in the lower space 12; an opening 13 is arranged in the middle of the upper surface of the upper space 11, and the opening 13 is sealed by an easy-to-tear adhesive 2; a color-changing heat-sensitive sticker 3 that changes color at 40 degrees Celsius is arranged in the middle of the lower surface of the lower space 12; and an easy-to-tear opening 14 is arranged at one end of the compartmentalized outer package bag 1.

[0050] Preferably, the heating pad is a paper bag containing a heating material.

[0051] Preferably, the heating material comprises iron powder, activated carbon, vermiculite, water and salt, and the heating principle is to generate heat by using the heat released by the oxidation reaction of iron.

[0052] Preferably, the color-changing heat-sensitive sticker 3 is a reversible color-changing heat-sensitive sticker, and the heat-sensitive material reversibly changes color at a temperature threshold.

[0053] Preferably, the size of the inner core is 7*10 cm.

[0054] Preferably, the size of the upper and lower sticking cloths 53 and 51 is 12*16 cm.

[0055] Preferably, the manufacturing method of the inner core of the summer and autumn version is as follows: Rhizoma Polygoni Cuspidati 8 parts, Radix et Rhizoma Rhei 6 parts, Radix Scutellariae 6 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 6 parts, Herba Menthae 1 part and Borneolum Syntheticum 1 part are mixed, crushed and ground; Sesami Oil 3 parts and Honey 3 parts are added for preparation to form a 7*10 cm inner core of the summer and autumn version.

[0056] Preferably, the manufacturing method of the inner core of the winter and spring version is as follows: Rhizoma Polygoni Cuspidati 8 parts, Radix et Rhizoma Rhei 6 parts, Radix Scutellariae 6 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 6 parts, Radix Angelicae Pubescentis 1 part and Herba Angelicae Pubescentis 1 part are mixed, crushed and ground; Sesami Oil 3 parts and Honey 3 parts are added for preparation to form a 7*10 cm inner core of the winter and spring version.

[0057] Preferably, the use method of the rhizoma tigillii four-huang phlebitis patch is as follows: tear the easy-to-tear opening 14 to expose the outer dressing 5 when the color-changing heat-sensitive patch 3 changes color, which indicates that the temperature of the outer dressing 5 has reached the proper level; place the outer dressing 5 on the upper part of the puncture point 3-5 cm along the vein direction, and place a towel pad under the limb; after external application for half an hour, ask the patient whether there is pain, and observe whether there is phlebitis and whether the medication site is red and swollen.

[0058] Example One

[0059] The rhizoma tigillii four-huang phlebitis patch comprises an outer dressing 5, a towel pad, and an auxiliary heating type outer package.

[0060] The outer dressing 5 comprises an upper patch cloth 53, a lower patch cloth 51, and a summer and autumn type inner core; the upper patch cloth 53 and the lower patch cloth 51 are adhesive cloth patches, and the winter and spring type inner core is arranged between the upper patch cloth 53 and the lower patch cloth 51.

[0061] Preparation of the winter and spring type inner core: mix rhizoma tigillii 8 parts, radix et rhizoma rhei 6 parts, radix scrophulariae 6 parts, radix coptidis 6 parts, radix coptidis 6 parts, angelica pubescens 1 part, and nung-wu 1 part, crush and grind them, add sesame oil 3 parts and honey 3 parts, and mix them to prepare a winter and spring type inner core with a size of 7*10 cm.

[0062] The towel pad is used to pad under the limb.

[0063] The outer dressing 5 is arranged in the auxiliary heating type outer package.

[0064] The auxiliary heating type outer package comprises a partition type outer package bag 1, which is divided into an upper space 11 and a lower space 12; a warm pack is arranged in the upper space 11, and the warm pack is a paper bag containing a heating material; the heating material comprises iron powder, activated carbon, vermiculite, water, and salt, and the heating principle is to generate heat by iron oxidation reaction;

[0065] The outer dressing 5 is arranged in the lower space 12; an opening 13 is arranged in the middle of the upper surface of the upper space 11, and the opening 13 is sealed by an easy-to-tear opening 14; a color-changing heat-sensitive patch 3 that can change color at 40 degrees Celsius is arranged in the middle of the lower surface of the lower space 12; the color-changing heat-sensitive patch 3 is a reversible color-changing heat-sensitive patch; and one end of the partition type outer package bag 1 is provided with an easy-to-tear opening 14.

[0066] The use method of the Polygonum Cuspidatum Four Yellow Phlebitis Paste is that: the heat bead 4 in the interlayer type outer packaging bag 1 is contacted with the outside air to start heating, and the heat is transmitted to the external dressing 5 through the interlayer between the upper space 11 and the lower space 12 to preheat the external dressing 5; when the color-changing heat-sensitive paste 3 changes color, it indicates that the temperature of the external dressing 5 is heated to the right position, at which time the easy-to-tear opening 14 is torn to take out the external dressing 5; the external dressing 5 is covered on the puncture point 3-5 cm above along the vein direction, and a towel pad is placed under the limb; after external application for half an hour, the patient is asked whether there is pain, and the occurrence of phlebitis symptoms and the redness and swelling of the medication site are observed.

[0067] Example Two

[0068] The Polygonum Cuspidatum Four Yellow Phlebitis Paste comprises an external dressing 5, a towel pad and an auxiliary heating type outer packaging.

[0069] The external dressing 5 comprises an upper cloth 53, a lower cloth 51 and a summer and autumn type inner core; the upper cloth 53 and the lower cloth 51 are adhesive cloth pastes, and the summer and autumn type inner core is arranged between the upper cloth 53 and the lower cloth 51.

[0070] The summer and autumn type inner core is made by mixing Polygonum Cuspidatum 8g, Radix et Rhizoma Rhei 6g, Radix Scutellariae 6g, Rhizoma Coptidis 6g, Cortex Phellodendri 6g, Mentha 1g and borneol 1g, crushing and grinding, and then adding sesame oil 3g and honey 3g for preparation into a summer and autumn type inner core of 7*10cm.

[0071] The towel pad is used to be placed under the limb.

[0072] The external dressing 5 is arranged in the auxiliary heating type outer packaging.

[0073] The auxiliary heating type outer packaging comprises an interlayer type outer packaging bag 1, which is divided into an upper space 11 and a lower space 12; a heat bead is arranged in the upper space 11, and the heat bead is a paper bag containing a heating material; the heating material comprises iron powder, activated carbon, vermiculite, water and salt, and the heating principle is to generate heat by iron oxidation reaction;

[0074] The external dressing 5 is arranged in the lower space 12; an opening 13 is arranged in the middle of the upper surface of the upper space 11, and the opening 13 is sealed by an easy-to-tear adhesive 2 outside; a color-changing heat-sensitive paste 3 that can change color at 40 degrees Celsius is arranged in the middle of the lower surface of the lower space 12; and an easy-to-tear opening 14 is arranged at one end of the interlayer type outer packaging bag 1.

[0075] The use method of the Polygonum Cuspidatum Four-Huang Phlebitis Paste is as follows: tear the warm pack 4 in the interlayer outer packaging bag 1 to contact the outside air to start heating, the heat is transmitted to the external dressing 5 through the interlayer between the upper space 11 and the lower space 12 to preheat the external dressing 5; when the color-changing heat-sensitive paste 3 changes color, it indicates that the temperature of the external dressing 5 is heated to the right position, at this time, tear the easy-to-tear opening 14 to take out the external dressing 5; cover the external dressing 5 on the puncture point 3-5 cm above along the vein direction, place a towel pad under the limb; after external application for half an hour, ask the patient whether there is pain, observe whether there is phlebitis symptom during the period, and observe whether there is redness and swelling at the medication site.

[0076] Principle:

[0077] (1) Dialectical selection of prescription: the Polygonum Cuspidatum Four-Huang Decoction is composed on the basis of the Four-Huang Decoction commonly used in clinical medicine, with Polygonum Cuspidatum, Dahuang, Huangbai, Huanglian and Huangqin as the main prescription. In summer and autumn, add Mentha and Bingpian for better absorption; in winter and spring, replace Mentha and Bingpian with Duhuo or Qianghuo for blood activation and yang warming.

[0078] (2) Polygonum Cuspidatum: clearing heat and resolving toxicity, dispersing blood stasis and relieving pain, stopping bleeding, anti-inflammatory, astringent, preventing infection;

[0079] The Four-Huang Decoction has the effects of clearing heat and resolving toxicity, drying dampness and swelling, activating blood and relieving pain, and astringency;

[0080] Dahuang: activating blood and resolving stasis, improving capillary fragility; it has the effects of cooling blood and resolving toxicity, removing stasis and unblocking channels, as recorded in Benjing: “for blood stasis, blood clots, cold and heat, breaking symptoms, accumulation and aggregation”, Rihua Zi Bencao: “promoting qi, regulating blood, benefiting joints, unblocking stagnation, water and qi, cold and heat of limbs, and applying to all kinds of sores, carbuncles and abscesses”, modern research shows that Dahuang has the effects of antibacterial, anti-inflammatory, hemostatic, etc., and can be used externally for treating burns, pyogenic skin diseases, carbuncles and abscesses, etc.

[0081] Huangbai: clearing heat and purging fire, detoxifying; it has the effects of clearing heat and drying dampness, purging fire and removing heat, detoxifying and treating sores, as recorded in Mingyi Bie Lu: “treating shock, qi in the skin, hot and red skin, hot and red eyes, mouth sores”, Yongyao Xinfa: “treating sore pain that cannot be endured”, modern research shows that Huangbai has the effects of antibacterial and anti-inflammatory, anti-ulcer and external use for promoting absorption of subcutaneous hemorrhage, etc., and can be used for treating sores, abscesses, flaccidity and damp eczema and itching, etc.

[0082] Huangqin: clearing heat and drying dampness, purging lung fire and detoxifying;

[0083] Huanglian: clearing heat, purging fire, drying dampness and detoxifying.

[0084] Mint is the volatile oil of Chinese mint, with the effects of dispelling wind, dispelling heat, dispelling evil, and detoxifying. As recorded in the “Theory of Drug Properties”: “Eliminate anger, release toxic sweat, break blood to stop diarrhea, and open joints”, as recorded in the “Compendium of Materia Medica”: “Treat scrofula, sores, and pruritic eruptions”, modern research shows that mint has the effects of antibacterial and anti-inflammatory, stimulating the cold receptors of nerve endings, and promoting drug transdermal absorption.

[0085] Borneol: opening the orifices, refreshing, clearing heat and relieving pain;

[0086] Angelica: dispelling wind and cold, often used to improve physical discomfort caused by cold or heavy moisture;

[0087] Notopterygium: dispelling cold and relieving pain.

[0088] The whole prescription has the effects of activating blood and resolving stasis, clearing heat and resolving toxins, resolving stasis and relieving pain, stopping bleeding, anti-inflammatory, astringent, and preventing infection.

[0089] The evaluation criteria for phlebitis are:

[0090] 0 degree: no clinical symptoms (signs);

[0091] I degree: local pain, redness or edema, no cord-like changes in veins, no hard nodules;

[0092] II degree: local pain, redness or edema, cord-like changes in veins, no hard nodules;

[0093] III degree: local pain, redness or edema, cord-like changes in veins, hard nodules can be touched.

[0094] 0 degree: no phlebitis, I degree, II degree and III degree: phlebitis.

[0095] Clinical application:

[0096] 180 patients with intravenous sodium aescinate in the foot and ankle center of Henan Luoyang Orthopedic Hospital (Henan Orthopedic Hospital) from June 2020 to December 2021 were selected as the research objects, and were divided into control group, magnesium sulfate group and Rheum officinale four yellow phlebitis patch group according to the order of admission, 60 cases in each group. In the control group, 42 males and 18 females, aged 23-67 years, with an average of (45.91±7.40) years. In the magnesium sulfate group, 40 males and 20 females, aged 22-67 years, with an average of (44.90±7.26) years. In the Rheum officinale four yellow phlebitis patch group, 46 males and 14 females, aged 25-68 years, with an average of (46.10±7.25) years. There was no statistically significant difference in general data among the three groups (P>0.05), and they were comparable. This study has been reviewed by the Medical Ethics Committee of Henan Luoyang Orthopedic Hospital (Henan Orthopedic Hospital).

[0097] The control group used the conventional care program, before treatment, conventional education and strengthen the tour, check the puncture point and local skin conditions and give timely treatment.

[0098] The magnesium sulfate group used 50% magnesium sulfate (Hebei Tiancheng Pharmaceutical Co., Ltd., National Drug Code H20033861) hot compress on the basis of the control group, mixed magnesium sulfate powder with 35-40 ℃ water according to the ratio of 1:1, covered the sterile gauze on the puncture point 3-5 cm above, and fixed with transparent dressing.

[0099] The polygonum cuspidatum four yellow phlebitis paste group contacted the outside air and began to heat when the heating pad 4 in the outer packaging bag 1 with interlayer was torn open, and the heat was transmitted to the external dressing 5 through the interlayer between the upper space 11 and the lower space 12, so that the external dressing 5 was preheated. When the color-changing heat-sensitive paste 3 changed color, it meant that the temperature of the external dressing 5 was heated to the right position. At this time, the external dressing 5 was removed by tearing the easy-to-tear opening 14. The external dressing 5 was covered on the puncture point 3-5 cm above along the vein direction, and the towel pad was placed under the limb.

[0100] The three groups used 24G safety type BD indwelling needle and disposable precision filter infusion set for puncture infusion in the forearm vein.

[0101] Both used 20 mg of esculin sodium for injection (Hubei Changlian Pharmaceutical Co., Ltd., National Drug Code H20003367) dissolved in 0.9% sodium chloride solution 250 mL for intravenous infusion. The puncture point and the surrounding skin were disinfected with an iodine. After infusion of the drug, the intervention measures were implemented along the vein direction.

[0102] The course of treatment was 4 days, once a day. The patients in the magnesium sulfate group and the polygonum cuspidatum four yellow phlebitis paste group were treated with external application 5 minutes after drug infusion and removed 30 minutes after the completion of esculin sodium infusion.

[0103] Statistical methods: SPSS 24.0 statistical software was used for data processing and analysis. Measurement data was expressed as mean ± standard deviation (x ± s), paired sample t test was used for intragroup comparison, one-way analysis of variance was used for intergroup comparison, and LSD method was used for further pairwise comparison; count data was expressed as percentage (%), and χ2 test was used. The test level α = 0.05, P < 0.05 indicates that the difference is statistically significant.

[0104] Results: After 4 days of treatment, the incidence of phlebitis in the polygonum cuspidatum four yellow phlebitis paste group was 11.67%, the incidence of phlebitis in the magnesium sulfate group was 23.33%, and the incidence of phlebitis in the control group was 33.33%. The incidence of phlebitis in the polygonum cuspidatum four yellow phlebitis paste group was lower than that in the magnesium sulfate group and the control group, and the difference was statistically significant (P < 0.05).

[0105] In the description of the present application, it is to be understood by those ordinary skilled in the art that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0106] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those ordinary skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0107] The above is only the preferred embodiment of the present application, and it should be pointed out that for those ordinary skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. Polygonum cuspidatum four yellow phlebitis patch, characterized in that, It includes an external dressing (5), a towel pad and an auxiliary heating outer packaging; The outer dressing (5) comprises an upper patch (53), a lower patch (51) and an inner core (52); the upper patch (53) and the lower patch (51) are adhesive tapes, and the inner core (52) is placed between the upper patch (53) and the lower patch (51); The inner core (52) is a Chinese medicine ointment, and the inner core (52) is divided into two types: summer and autumn type and winter and spring type; The summer and autumn style inner core is composed of the following raw materials in parts by weight: 8 parts of Polygonum cuspidatum, 6 parts of Rhubarb, 6 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 6 parts of Phellodendron amurense, 1 part of Menthol, 1 part of Borneolum Syntheticum, 3 parts of Sesame Oil and 3 parts of Honey; The winter and spring style inner core is composed of the following raw materials in parts by weight: 8 parts of Polygonum cuspidatum, 6 parts of Rhubarb, 6 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 6 parts of Phellodendron amurense, 1 part of Angelica dahurica, 1 part of Notopterygium wilfordii, 3 parts of sesame oil and 3 parts of honey; The towel pad is used to pad under the limbs; The outer dressing (5) is contained in the auxiliary heating outer packaging; The auxiliary heating outer packaging comprises an interlayer outer packaging bag (1), which is divided into an upper space (11) and a lower space (12), wherein a heating pad is arranged in the upper space (11), and the outer dressing (5) is arranged in the lower space (12); an opening (13) is arranged in the middle of the upper surface of the upper space (11), and the outside of the opening (13) is sealed by an easy-tear adhesive (2); a color-changing thermal sticker (3) that can change temperature at (40) degrees Celsius is arranged in the middle of the lower surface of the lower space (12); and an easy-tear opening (14) is arranged at one end of the interlayer outer packaging bag (1).

2. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that A hot pack is a heating material packed in a paper bag.

3. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that: The heating material includes iron powder, activated carbon, vermiculite, water and salt, and the heating principle is to generate heat by utilizing the heat released by the iron oxidation reaction.

4. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that The color-changing thermosensitive patch (3) is a reversible color-changing thermosensitive patch.

5. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that: The size of the inner core is 7*10 cm; the size of the upper patch (53) and the lower patch (51) is 12*16 cm.

6. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that: The preparation method of the summer and autumn inner core is as follows: mix 8 parts of Japanese knotweed, 6 parts of rhubarb, 6 parts of scutellaria, 6 parts of coptis, 6 parts of phellodendron, 1 part of mint, and 1 part of borneol, then crush and grind; add 3 parts of sesame oil and 3 parts of honey to make a 7*10cm summer and autumn inner core.

7. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that: The method for making the winter-spring inner core is as follows: mix 8 parts of Japanese knotweed, 6 parts of rhubarb, 6 parts of scutellaria, 6 parts of coptis, 6 parts of phellodendron, 1 part of angelica dahurica, and 1 part of notopterygium wilfordii, crush and grind the mixture; add 3 parts of sesame oil and 3 parts of honey to make a 7*10cm winter-spring inner core.

8. The Polygonum cuspidatum phlebitis patch according to claim 1, characterized in that: The method of using the Polygonum cuspidatum phlebitis patch is as follows: tear open the patch (2), the heat pack (4) in the interlayer outer packaging bag (1) contacts the outside air and starts to heat up, and the heat is transmitted to the outer dressing (5) through the interlayer between the upper space (11) and the lower space (12), so that the outer dressing (5) is preheated; when the color-changing heat-sensitive patch (3) changes color, it means that the temperature of the outer dressing (5) has been heated to the right level, and the easy-tear opening (14) is torn open to take out the outer dressing (5); the outer dressing (5) is covered 3 to 5 cm above the puncture point along the direction of the vein, and a towel pad is placed under the limb; after half an hour of external application, the patient is asked whether he has pain, and during this period, whether symptoms of phlebitis occur, and whether the medication site is red and swollen.

9. Use of the Polygonum cuspidatum and Four-yellow Phlebitis Patch according to any one of claims 1 to 7 in the preparation of a medicament for preventing or treating phlebitis caused by sodium aescinate injection.

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