Traditional Chinese medicine compound preparation for treating allergic rhinitis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method. The traditional Chinese medicine compound preparation is prepared from 15-30 g of radix astragali, 10-15 g of fructus xanthii, 10-15 g of flos magnoliae, 3-6 g of herba asari, 10-25 g of raw herba ephedrae, 15-20 g of cortex mori radicis, 10-15 g of flos lonicerae, 15-30 g of radix saposhnikoviae, 15-20 g of herba pogostemonis, 10-15 g of radix angelicae and 10-15 g of rhizoma atractylodis. The traditional Chinese medicine compound preparation disclosed by the invention has the beneficial effects that the traditional Chinese medicine compound preparation is used for comprehensively conditioning different symptoms of allergic rhinitis through combination of various traditional Chinese medicinal materials. The medicinal materials such as astragalus membranaceus, white mulberry root-bark and divaricate saposhnikovia root have the effects of enhancing immunity and resisting allergy, and the medicinal materials such as magnolia flower and cocklebur fruit can dredge the nasal cavity and relieve nasal obstruction; the honeysuckle, the radix angelicae, the schisandra chinensis and other medicinal materials have the effects of clearing away heat and toxic materials, diminishing inflammation and resisting bacteria. The compound improves the effect of treating allergic rhinitis through multi-aspect pharmacological action.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method. BACKGROUND

[0002] Allergic rhinitis is a common immune system disease, which is characterized by nasal congestion, runny nose, sneezing, and nasal itching, and is usually caused by allergens in the air, such as pollen, dust mites, and animal dander. The pathogenesis of this disease is mainly the abnormal reaction of the immune system, which leads to inflammation of the nasal mucosa. The existing treatment methods include antihistamine drugs, steroid drugs, and immunotherapy, but these treatment methods are usually accompanied by certain side effects, such as drowsiness, dry mouth, and weight gain.

[0003] In the field of traditional Chinese medicine, the treatment of allergic rhinitis mainly relies on the unique compatibility of traditional Chinese medicinal materials, which can regulate immune function, relieve inflammation of the nasal mucosa, and eliminate external evils to treat the disease. Traditional Chinese medicine compound treatment shows good effect in relieving symptoms and reducing side effects, and has relatively high safety for long-term use.

[0004] However, there are many kinds of traditional Chinese medicine compound preparations for treating allergic rhinitis at present, and many of these compounds are effective, but their formulations are complex, the preparation process is unstable, which leads to different drug effects, and the product form is single, which is not convenient for long-term use by patients. Therefore, it is urgent to develop a new traditional Chinese medicine compound preparation that can effectively treat allergic rhinitis and ensure the stability of drug efficacy and the convenience of patient use. SUMMARY

[0005] The purpose of the present application is to solve the above problems, and a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method are designed.

[0006] To achieve the above purpose, the technical scheme of the present application is a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method, which comprises 15-30 grams of Huangqi, 10-15 grams of Xiang'ezi, 10-15 grams of Xinyi, 3-6 grams of Xixin, 10-25 grams of Shengmaohuang, 15-20 grams of Sangbaipi, 10-15 grams of Jinhuahua, 15-30 grams of Fangfeng, 15-20 grams of Guanghuoxiang, 10-15 grams of Baiqi, 10-15 grams of Cangshu, 3-6 grams of Tianyeju, 10-15 grams of Wumei, 10-15 grams of Banlangen, 10-15 grams of Shichangpugu, 10-15 grams of Chao-bai-shu, 15-30 grams of Jiuchuanqiong, and 15-30 grams of Dannaixing.

[0007] A preparation method of a traditional Chinese medicine compound preparation for treating allergic rhinitis, comprising the following steps: S1: Wash and remove impurities from the following traditional Chinese medicinal materials: Huangqi, Xiang'erzi, Xinyi, Xixin, Shengmaohuang, Sangbaipi, Jinyinhua, Fangfeng, Guanghuoxiang, Baizhi, Cangshu, Tianyekaiye, Wuzi, Wumei, Banlangen, Shichangpu, Chao baizhu, Jiuchuanqiong, and Dananxing, etc. Dry them as needed. S2: Grind the cleaned traditional Chinese medicinal materials under dry conditions to obtain fine powder. The grinding degree of different medicinal materials can be adjusted according to the efficacy requirements, but the fineness of the powder should be moderate to facilitate subsequent extraction. S3: Add an appropriate amount of water or suitable solvent to the ground traditional Chinese medicinal powder according to the ratio of each medicinal material, and extract at a temperature of 60-80°C for 2-3 times, with each extraction time being 30-60 minutes. Reflux extraction or ultrasonic extraction techniques can be used during the extraction process to improve the extraction efficiency. S4: After filtering the extraction liquid to remove impurities, use the method of reduced pressure concentration to concentrate the extraction liquid to a certain concentration to form a concentrated liquid. S5: Dry the concentrated liquid into a dry powder by spray drying, freeze-drying, or vacuum drying. The temperature during drying should be controlled below 60°C to avoid the volatilization and destruction of effective components of medicinal materials. S6: Add an appropriate amount of excipients (such as starch, dextrin, etc.) to the dried traditional Chinese medicinal powder, and make granules by wet granulation or dry granulation method. The size of the granules should be adjusted according to the oral administration form and the needs of patients. S7: Package the prepared granules according to the dosage, and use suitable packaging materials for sealing to ensure the stability and effective components are not affected by the external environment.

[0008] Preferably, the Huangqi is 20 grams.

[0009] Preferably, the Xinyi is 10 grams.

[0010] Preferably, the Fangfeng is 15 grams.

[0011] Preferably, the Wuzi is 15 grams.

[0012] Preferably, the Dananxing is 25 grams.

[0013] Preferably, the Jiuchuanqiong is 20 grams.

[0014] Preferably, the Cangshu is 12 grams.

[0015] Preferably, the Jinyinhua is 12 grams.

[0016] The application discloses a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method thereof. DETAILED DESCRIPTION

[0017] Embodiment 1 The application discloses a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method thereof.

[0018] Embodiment 2 The application discloses a traditional Chinese medicine compound preparation for treating allergic rhinitis and a preparation method thereof. S1: the traditional Chinese medicinal materials such as Astragalus membranaceus, Xanthium sibiricum, Magnolia biondii, Asarum, Ephedra sinica, Morus alba, Lonicera japonica, Saposhnikovia divaricata, Pogostemonis Herba, Angelica dahurica, Atractylodes lancea, Stevia rebaudiana, Schisandra chinensis, Prunus mume, Isatis indigotica, Acorus gramineus, Paeonia lactiflora, and Chuanxiong are cleaned, impurities are removed, and the traditional Chinese medicinal materials are dried according to the needs; S2: the cleaned traditional Chinese medicinal materials are crushed under dry conditions to obtain fine powder; the crushing degree of different medicinal materials can be adjusted according to the medicinal effect requirements, but the fineness of the powder should be moderate, so that the subsequent extraction is facilitated; S3: the crushed traditional Chinese medicinal powder is added with appropriate water or solvent, and extracted for 2-3 times at 60-80 DEG C, and the extraction time is 30-60 minutes each time; the extraction process can adopt reflux extraction or ultrasonic extraction technology to improve the extraction efficiency; S4: after the extraction liquid is filtered to remove impurities, the extraction liquid is concentrated to a certain concentration by a reduced-pressure concentration method to form a concentrated liquid; S5: the concentrated liquid is dried into dry powder by a spray drying, freeze drying or vacuum drying method; during the drying process, the temperature should be controlled to be lower than 60 DEG C, so that the volatilization and damage of effective components of the traditional Chinese medicinal materials are avoided; S6: The dried traditional Chinese medicine powder is added with appropriate amount of excipients (such as starch, dextrin, etc.), and granules are prepared by wet granulation method or dry granulation method. The size of the granules should be adjusted according to the oral administration form and the needs of the patients; S7: The prepared granules are divided into doses, sealed and packaged with appropriate packaging materials to ensure the stability and effective components are not affected by the external environment.

[0019] Further, the Astragalus membranaceus is 20 grams.

[0020] Further, the Magnolia biondii is 10 grams.

[0021] Further, the Saposhnikovia divaricata is 15 grams.

[0022] Further, the Schisandra chinensis is 15 grams.

[0023] Further, the Arisaema cum Bile is 25 grams.

[0024] Further, the Chuanxiong Rhizome is 20 grams.

[0025] Further, the Atractylodes lancea is 12 grams.

[0026] Further, the Honeysuckle is 12 grams.

[0027] The above technical solutions only reflect the preferred technical solutions of the present application, and some changes made by the skilled in the art to some parts thereof all embody the principles of the present application and are within the protection scope of the present application.

Claims

1. A Chinese medicinal compound preparation for treating allergic rhinitis, characterized in that: Including 15-30 grams of Astragalus, 10-15 grams of Xanthium sibiricum, 10-15 grams of Magnolia, 3-6 grams of Asarum, 10-25 grams of raw Ephedra, 15-20 grams of Morus alba, 10-15 grams of Honeysuckle, 15-30 grams of Saposhnikovia divaricata, 15-20 grams of Patchouli, 10-15 grams of Angelica dahurica, 10-15 grams of Atractylodes, 3-6 grams of Stevia leaves, 10-15 grams of Schisandra chinensis, 15-30 grams of Prunus mume, 10-15 grams of Isatis root, 10-15 grams of Acorus calamus, 10-15 grams of stir-fried Atractylodes, 15-30 grams of Ligusticum chuanxiong, and 15-30 grams of Arisaema consanguineum.

2. A method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis, characterized in that: The following steps are involved: S1: Wash and remove impurities from the Chinese medicinal materials such as Astragalus, Xanthium sibiricum, Magnolia Flos, Asarum, Ephedra sinica, Morus alba, Honeysuckle, Saposhnikovia divaricata, Patchouli, Angelica dahurica, Atractylodes macrocephala, Stevia rebaudiana leaves, Schisandra chinensis, Prunus mume, Radix Isatidis, Acorus calamus, stir-fried Atractylodes macrocephala, Ligusticum chuanxiong and Arisaema cinerea respectively, and dry them as needed; S2: Grind the cleaned Chinese medicinal materials under dry conditions to obtain fine powder. The degree of grinding of different medicinal materials can be adjusted according to the desired efficacy, but the fineness of the powder must be moderate to facilitate subsequent extraction; S3: Add an appropriate amount of water or a suitable solvent to the crushed Chinese herbal medicine powder according to the ratio of each medicinal material, and extract it 2-3 times at a temperature of 60°C-80°C, with each extraction time being 30-60 minutes. Reflux extraction or ultrasonic extraction can be used during the extraction process to improve the extraction efficiency; S4: After filtering the extract to remove impurities, the extract is concentrated to a certain concentration by a reduced pressure concentration method to form a concentrated solution; S5: Prepare the concentrated solution into dry powder by spray drying, freeze drying or vacuum drying. During the drying process, the temperature should be controlled below 60°C to avoid volatilization and destruction of the active ingredients of the medicinal materials; S6: Add appropriate amounts of excipients (such as starch, dextrin, etc.) to the dried TCM powder and prepare granules by wet or dry granulation. The granule size should be adjusted according to the oral administration form and patient needs. S7: The prepared granules are divided into packages according to dosage and sealed with appropriate packaging materials to ensure their stability and that the active ingredients are not affected by the external environment.

3. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 2, characterized in that: 20 grams of the astragalus root.

4. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 2, wherein: The magnolia 10 = grams.

5. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 3, characterized in that: Described windproof 15= gram.

6. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 1, characterized in that: 15 grams of Schisandra chinensis.

7. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 1, characterized in that: The described Arisaema consanguineum is 25 grams.

8. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 1, characterized in that: The wine-cooked Chuanxiong is 20 grams.

9. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 1, characterized in that: The Atractylodes lancea is 12 grams.

10. The method for preparing a Chinese medicinal compound preparation for treating allergic rhinitis according to claim 1, characterized in that: The honeysuckle is 12 grams.