Dissolving device for heparin sodium production raw material pretreatment process

Abstract

The invention relates to the field of dissolving and stirring, in particular to a dissolving device for a heparin sodium production raw material pretreatment process, which comprises a dissolving kettle, a driving mechanism connected to the dissolving kettle, a rotating pipe connected to the driving mechanism, an anchor-type stirring paddle fixedly connected to the rotating pipe, and two fixed covers fixedly connected to the stirring paddle, the two fixing covers are arc-shaped, a plurality of cavities are formed in the inner sides of the two fixing covers, the cavities are through front and back, openings are formed in one ends of the cavities, mincing teeth are arranged on the upper inner walls and the lower inner walls of the cavities, two rotating shafts are connected to the driving mechanism, a plurality of rotating blocks are fixedly connected to the two rotating shafts, and a plurality of matching teeth are arranged on the upper faces and the lower faces of the rotating blocks. The device can utilize the stirring structure to conduct mincing treatment on the mucous membrane of the small intestine of the pig, and the stirring efficiency is further improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of dissolution stirring, in particular to a dissolution device for raw material pretreatment process of heparin sodium production. BACKGROUND

[0002] Heparin sodium is an anticoagulant, and the main raw material for processing heparin sodium is pig small intestine mucosa. Before processing heparin sodium, the pig small intestine needs to be pretreated. Fresh pig small intestine is taken, the mucosa of the pig small intestine is scraped off, and then the mucosa of the pig small intestine is twisted into a paste by a crusher. The paste-like pig small intestine mucosa is transferred to a stirrer, and a 5.5% sodium chloride solution is added for stirring treatment. The pig small intestine mucosa is subjected to salt dissolution treatment to promote the separation of protein and heparin. In this process, the pig small intestine mucosa needs to be transferred multiple times, which consumes time and labor, and increases the labor intensity of subsequent cleaning equipment. SUMMARY

[0003] Therefore, the technical problem to be solved by the present application is to provide a dissolution device for raw material pretreatment process of heparin sodium production, which can use a stirring structure to twist the pig small intestine mucosa, thereby further improving the stirring efficiency.

[0004] A dissolution device for raw material pretreatment process of heparin sodium production, comprising a dissolution kettle, a driving mechanism connected to the dissolution kettle, a rotating pipe connected to the driving mechanism, an anchor-shaped stirring paddle fixedly connected to the rotating pipe, two fixed covers fixedly connected to the stirring paddle, the two fixed covers being arc-shaped, a plurality of cavities formed in the inner sides of the two fixed covers, the cavities being through from front to back, an opening formed at one end of each cavity, a plurality of twisting teeth formed on the upper and lower inner walls of each cavity, two rotating shafts connected to the driving mechanism, a plurality of rotating blocks fixedly connected to the two rotating shafts, and a plurality of matching teeth formed on the upper and lower surfaces of each rotating block.

[0005] The cavities are trapezoidal and gradually widen from the opening end, and the rotating blocks are trapezoidal.

[0006] The driving mechanism comprises a mounting seat, a driving motor fixedly connected to the mounting seat, a first gear fixedly connected to the output shaft of the driving motor, the rotating pipe rotatably connected to the mounting seat, a gear ring fixedly connected to the upper end of the rotating pipe, and the first gear and the gear ring in meshing transmission.

[0007] The driving mechanism further comprises an electric push rod, a lifting frame fixedly connected to the moving end of the electric push rod, the two rotating shafts rotatably connected to the lifting frame, a second gear fixedly connected to the upper end of each rotating shaft, and the two second gears in meshing transmission with the gear ring.

[0008] The pitch circle radius of the gear ring is four times the pitch circle radius of the second gear.

[0009] The lower end of the rotating pipe is fixedly connected to an air cylinder, and a plurality of air exhaust grooves are formed on the surface of the air cylinder.

[0010] A baffle is fixedly connected to the surface of each rotating block.

[0011] Each baffle surface is provided with a groove.

[0012] A cleaning sheet is fixedly connected to each baffle.

[0013] The beneficial effects of this application include: by controlling the speed difference between the impeller and the rotor, a vortex superposition effect is generated within the cavity. This design can improve the fiber breakage rate of the small intestinal mucosa compared to traditional devices, while reducing mechanical stress damage to intact tissue. The minced material has a larger specific surface area than the original mucosa. Increasing the contact area can increase the salt dissolution rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The present invention will be further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0015] Figure 1 The figure is a schematic diagram of the overall structure of a dissolving device used in the pretreatment process of raw materials for the production of heparin sodium; Figure 2 Schematic diagram of the structure of the gear ring; Figure 3 Schematic diagram of the structure of the stirring paddle; Figure 4 Schematic diagram of the structure of the lifting frame; Figure 5 is a structural diagram of the rotating shaft; Figure 6 It is the structural diagram of the transfer block; Figure 7 Schematic diagram of the structure of the exhaust slot; Figure 8 It is a cross-sectional view of the structure of the cylinder. DETAILED DESCRIPTION

[0016] The present invention is described in detail with reference to the accompanying drawings in the embodiments of the present invention.

[0017] The utility model provides a kind of dissolving device for heparin sodium production raw material pretreatment process, including dissolving kettle 101, driving mechanism is connected on dissolving kettle 101, driving mechanism is connected on rotating tube 301, anchor type is fixedly connected with stirring paddle 304 on rotating tube 301, two fixed covers 401 are fixedly connected on stirring paddle 304, two fixed covers 401 are arc-shaped, multiple cavities 402 are formed in the inside of two fixed covers 401, and the cavities 402 are through from front to back, and the one end of cavity 402 is provided with opening 404, and multiple material twisting teeth 403 are arranged on the upper and lower two inner walls of cavity 402, two rotating shafts 501 are connected on driving mechanism, and multiple rotating blocks 502 are fixedly connected on the two rotating shafts 501, and multiple cooperation teeth 503 are arranged on the upper and lower two surfaces of rotating block 502.

[0018] Cavity 402 is trapezoidal, and gradually widens from the one end of opening 404, and rotating block 502 is trapezoidal.

[0019] Driving mechanism includes mounting seat 201, driving motor 203 is fixedly connected on mounting seat 201, first gear 202 is fixedly connected on the output shaft of driving motor 203, rotating tube 301 is rotatably connected on mounting seat 201, and gear ring 204 is fixedly connected on the upper end of rotating tube 301, and first gear 202 is engaged with gear ring 204.

[0020] Driving mechanism further includes electric push rod 102, lifting frame 103 is fixedly connected on the moving end of electric push rod 102, two rotating shafts 501 are rotatably connected on lifting frame 103, second gear 104 is fixedly connected on the upper end of two rotating shafts 501, and two second gears 104 are engaged with gear ring 204.

[0021] The radius of the division circle of gear ring 204 is four times the radius of the division circle of second gear 104.

[0022] Air cylinder 302 is fixedly connected on the lower end of rotating tube 301, and multiple exhaust grooves 303 are formed on the surface of air cylinder 302.

[0023] Baffle 504 is fixedly connected on the surface of each rotating block 502.

[0024] Groove 505 is formed on the surface of each baffle 504.

[0025] Cleaning sheet 506 is fixedly connected on each baffle 504.

[0026] Each cleaning sheet 506 has elastic deformation capacity.

[0027] Refer Figures 1-5 , In use, the worker first adds the cleaned pig small intestine mucosa into the dissolving kettle 101, then adds the sodium chloride solution with a concentration of 5.5% into the dissolving kettle 101, and then drives the first gear 202 to rotate by controlling the driving motor 203, the first gear 202 is in meshing transmission with the gear ring 204, the gear ring 204 drives the rotating tube 301 to rotate, the rotating tube 301 drives the stirring paddle 304 to rotate, the stirring paddle 304 can realize the stirring effect of the pig small intestine mucosa and the sodium chloride solution, and the sodium chloride solution can be used for salt dissolution treatment of the pig small intestine mucosa, so as to promote the separation of the protein and heparin.

[0028] Referring to Figure 8 , The stirring paddle 304 is an anchor type, the anchor type stirring paddle can form a turbulent flow by rotating, can quickly break the liquid stratification, promote the mixing of materials, and is especially suitable for the stirring treatment of the pig small intestine mucosa and the sodium chloride solution; the close cooperation of the paddle blade outer edge and the container inner wall and the small gap can also remove the solid or viscous product attached to the wall surface, so as to avoid local concentration unevenness.

[0029] The gear ring 204 can also drive the two second gears 104 to synchronously rotate, the two second gears 104 drive the two rotating shafts 501 to synchronously rotate, and the two rotating shafts 501 drive the plurality of rotating blocks 502 to rotate, because the pitch circle radius of the gear ring 204 is four times the pitch circle radius of the second gear 104, the rotating speed of the two rotating shafts 501 can be accelerated, and the rotating speed of the two rotating shafts 501 is greater than the rotating speed of the rotating shaft 501.

[0030] Referring to Figures 5-6 , When the stirring paddle 304 is stirring the small intestine mucosa and the sodium chloride solution, the plurality of rotating blocks 502 rotate around the axis of the rotating shaft 501, so that the plurality of rotating blocks 502 can also realize the stirring treatment of the small intestine mucosa and the sodium chloride solution, and the rotating blocks 502 and the stirring paddle 304 cooperate to produce a shearing effect on the materials by using the rotating speed difference between the rotating shaft 501 and the rotating tube 301, so that the shearing and crushing effect can be realized while the small intestine mucosa is stirred, the small intestine mucosa can be further fully contacted with the sodium chloride solution, the salt dissolution effect is improved, compared with the conventional method of crushing first and then stirring, the time can be effectively saved, the materials can be avoided to be transferred for many times, and the labor and the equipment cleaning difficulty can be reduced.

[0031] During the rotation of the stirring paddle 304, the fixed cover 401 is arc-shaped, so that the rotating resistance of the stirring paddle 304 can be reduced, the materials can pass through the plurality of cavities 402 on the fixed cover 401, so that the rotating resistance of the stirring paddle 304 can be further reduced, the stirring resistance can be reduced and the propulsion force can be enhanced by the cooperation of the fixed cover 401 and the plurality of cavities 402, and the materials can be prevented from splashing and gas entrainment.

[0032] Referring to Figure 7 , Because the cavity 402 is through from front to back, the cavity 402 is provided with an opening 404 at one end, and the cavity 402 is trapezoidal and gradually widened from the opening 404, the rotating block 502 is also trapezoidal, and then when the stirring paddle 304 and the plurality of rotating blocks 502 rotate, the plurality of rotating blocks 502 can enter the plurality of cavities 402 of the stirring paddle 304 respectively, the matching teeth 503 on the surface of the rotating block 502 and the stranding teeth 403 in the cavity 402 match, and when the matching teeth 503 and the stranding teeth 403 relatively move, the small intestine mucosa between them can be torn into pieces, and in the case of differential rotation, the function of stranding the small intestine mucosa inside the cavity 402 can be realized, further refining the small intestine mucosa, so that the small intestine mucosa is in a minced state, and the dissolution of the small intestine mucosa is promoted.

[0033] The trapezoidal cavity 402 is gradually widened from the opening end, and the geometry of the trapezoidal rotating block 502 matches, forming a progressive stranding space. This design can effectively control the flow direction of the material, and when the stirring paddle 304 and the rotating block 502 rotate at different speeds, a spiral shear flow field is formed inside the cavity. The relative motion of the matching teeth 503 and the stranding teeth 403 generates multi-stage shear force, which improves the shearing efficiency compared with the traditional single blade structure.

[0034] By controlling the speed difference of the stirring paddle and the rotating block, a vortex superposition effect is formed in the cavity. This design can increase the fiber breakage rate of the small intestine mucosa compared with traditional devices, while reducing the damage of mechanical stress to the intact tissue. The specific surface area of the minced material after stranding is larger than that of the original mucosa. Increasing the contact area can increase the dissolution rate of the salt.

[0035] Referring to Figures 7-8 , In the process of stirring and stranding the small intestine mucosa, the exhaust pipe of the air pump is connected to the rotating pipe 301, air is transmitted into the rotating pipe 301, and then the air enters the air cylinder 302 and is discharged through a plurality of exhaust grooves 303. When the air passes through the plurality of exhaust grooves 303, the pressure increases, so as to impact the surrounding small intestine mucosa and sodium chloride solution, and cooperate with the rotation of the air cylinder 302 to diffuse around, avoid concentrating in the middle of the dissolving kettle 101, and further improve the stirring effect.

[0036] Referring to Figure 6 , Since each rotating block 502 is fixedly connected with a baffle 504, the rotating block 502 drives the baffle 504 to move when rotating, and the plurality of baffles 504 correspond to the positions of the plurality of exhaust grooves 303, and then the baffle 504 can shield the exhaust groove 303 when the baffle 504 rotates to the position of the exhaust groove 303, and a gap is left between the baffle 504 and the exhaust groove 303. The air discharged from the exhaust groove 303 is split into bubbles after contacting the baffle 504 and diffuses around, so as to further expand the range of bubble agitation.

[0037] The groove 505 on the baffle 504 further splits the generated bubbles. After the bubbles are discharged, they collide with the groove 505 on the baffle 504, which splits them into even smaller bubbles, so that the agitation effect of the bubbles is more uniform.

[0038] The plurality of cleaning pieces 506 correspond to the positions of the plurality of exhaust grooves 303. When the rotating block 502 drives the cleaning piece 506 to contact the exhaust groove 303, the cleaning piece 506 can be inserted into the exhaust groove 303, so as to avoid the small intestine mucosa being stuck in the exhaust groove 303 and avoid blocking the exhaust groove 303, thereby ensuring the exhaust efficiency. Since the plurality of cleaning pieces 506 are made of rubber material, the plurality of cleaning pieces 506 have elastic deformation capability. When the cleaning piece 506 contacts the surface of the air cylinder 302, it can automatically deform. When the cleaning piece 506 enters the exhaust groove 303, it can automatically reset according to its elastic capability, so as to avoid hard contact between the cleaning piece 506 and the air cylinder 302.

[0039] Referring to Figures 2-3 , After the small intestine mucosa is dissolved by salt, the plurality of rotating blocks 502 are controlled to be separated from the plurality of cavities 402. The staff controls the moving end of the electric push rod 102 to extend, so as to drive the lifting frame 103 to move upward. The lifting frame 103 drives the two second gears 104 to move upward and away from the tooth ring 204, and drives the two rotating shafts 501 and the plurality of rotating blocks 502 to move away from the dissolving kettle 101.

[0040] Since the two second gears 104 are separated from the tooth ring 204 at this time, when the tooth ring 204 is controlled to rotate again, the tooth ring 204 only drives the stirring paddle 304 to stir the small intestine mucosa. At this time, sodium hydroxide solution is added to the small intestine mucosa, so that the small intestine mucosa is fully mixed with the sodium hydroxide solution, the protein in the small intestine mucosa is denatured, and the degradation of heparin is avoided.

[0041] In this process, the rotating block 502 is no longer used to cooperate with the stirring paddle 304 to shred the small intestine mucosa. By the above operation, the two second gears 104 are separated from the tooth ring 204, so as to reduce the power loss in the rotating process of the tooth ring 204, further save resources, and improve the stirring efficiency.

Claims

1. A dissolving device for the pretreatment process of raw materials for the production of heparin sodium, characterized by: It includes a dissolving kettle, which is connected to a driving mechanism, which is connected to a rotating tube, which is fixedly connected to a stirring paddle, which is an anchor type stirring paddle, and is fixedly connected to two fixed covers, which are both arc-shaped, and have multiple cavities on the inner sides of the two fixed covers, which are connected from front to back, and have openings at one end of the cavities, and are provided with cutting teeth on the upper and lower inner walls of the cavities, and two rotating shafts are connected to the driving mechanism, which are fixedly connected to multiple rotating blocks, and multiple matching teeth are provided on the upper and lower surfaces of the rotating blocks.

2. A dissolving device for the pretreatment process of raw materials for the production of heparin sodium according to claim 1, characterized in that: The cavity is trapezoidal, gradually widening from the open end, and the turning block is trapezoidal.

3. A dissolving device for the pretreatment process of raw materials for heparin sodium production according to claim 2, characterized in that: The driving mechanism includes a mounting seat, a driving motor is fixedly connected to the mounting seat, a first gear is fixedly connected to the output shaft of the driving motor, a rotating tube is rotatably connected to the mounting seat, a gear ring is fixedly connected to the upper end of the rotating tube, and the first gear is meshed with the gear ring for transmission.

4. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 3, characterized in that: The driving mechanism also includes an electric push rod, the movable end of the electric push rod is fixedly connected to the lifting frame, the two rotating shafts are rotatably connected to the lifting frame, the upper ends of the two rotating shafts are fixedly connected to the second gear, and the two second gears are engaged with the gear ring for transmission.

5. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 4, characterized in that: The pitch circle radius of the gear ring is four times the pitch circle radius of the second gear.

6. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 5, characterized in that: The lower end of the rotating tube is fixedly connected with an air cylinder, and a plurality of exhaust grooves are opened on the surface of the air cylinder.

7. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 1, characterized in that: A baffle is fixedly connected to the surface of each rotating block.

8. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 7, characterized in that: A groove is provided on the surface of each baffle.

9. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 8, characterized in that: A cleaning sheet is fixedly connected to each baffle.

10. A dissolving device for pretreatment of raw materials for heparin sodium production according to claim 9, characterized in that: Each cleaning piece has elastic deformation capability.

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