Dissolving device for heparin sodium production raw material pretreatment process

By designing the anchor-type stirring paddle and the differential rotation of the trapezoidal cavity, combined with gas assistance, efficient mincing and salt dissolution of the pig small intestinal mucosa are achieved, solving the time-consuming transfer and stirring problems in the existing technology and improving production efficiency and equipment utilization.

CN120789998AActive Publication Date: 2025-10-17NANTONG TIANRUI BIOLOGICAL TECH CO LTD
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Patent Information

Application Number
CN202511299601.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-12
Publication Date
2025-10-17
Estimated Expiration
2045-09-12

AI Technical Summary

Technical Problem

In the existing technology for producing sodium heparin, the pretreatment process of the pig small intestinal mucosa requires multiple transfers and stirring, which is time-consuming and labor-intensive, and the equipment is difficult to clean.

Method used

A dissolution device consisting of an anchor-type stirring paddle and a trapezoidal cavity was designed. The differential rotation of the stirring paddle and the rotor formed a vortex superposition effect. Combined with gas-assisted stirring, efficient mincing and salt dissolution of the pig small intestinal mucosa were achieved.

Benefits of technology

It improves the fiber breakage rate and salt dissolution rate of the pig small intestinal mucosa, reduces the damage to the tissue caused by mechanical stress, saves time and labor, and reduces the difficulty of equipment cleaning.

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Abstract

The invention relates to the field of dissolving and stirring, in particular to a dissolving device for a heparin sodium production raw material pretreatment process, which comprises a dissolving kettle, a driving mechanism connected to the dissolving kettle, a rotating pipe connected to the driving mechanism, an anchor-type stirring paddle fixedly connected to the rotating pipe, and two fixed covers fixedly connected to the stirring paddle, the two fixing covers are arc-shaped, a plurality of cavities are formed in the inner sides of the two fixing covers, the cavities are through front and back, openings are formed in one ends of the cavities, mincing teeth are arranged on the upper inner walls and the lower inner walls of the cavities, two rotating shafts are connected to the driving mechanism, a plurality of rotating blocks are fixedly connected to the two rotating shafts, and a plurality of matching teeth are arranged on the upper faces and the lower faces of the rotating blocks. The device can utilize the stirring structure to conduct mincing treatment on the mucous membrane of the small intestine of the pig, and the stirring efficiency is further improved.
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