Hydrogel coating patch

Abstract

The invention discloses a hydrogel coating patch, which comprises a base material, a medicine carrying strip and a hydrogel coating, and realizes differentiated medicine delivery to different areas of a coronary sulcus of a penis, so that ejaculation is delayed, erection time is prolonged, and influence on sexual pleasure is avoided as far as possible.

Description

Technical Field

[0001] This invention belongs to the field of hydrogel patch technology, and particularly relates to a hydrogel coated patch, and further to a novel targeted topical disposable male hydrogel patch for delaying ejaculation and improving erectile function. Background Technology

[0002] Premature ejaculation (PE) is a common problem affecting approximately 20% to 40% of adult men in different parts of the world. In addition to physical effects, PE can lead to psychological and emotional problems such as low satisfaction, decreased self-esteem, and anxiety. It can also strain romantic relationships, causing interpersonal problems and reduced intimacy, creating a vicious cycle.

[0003] Currently, various treatment methods are available on the market to increase male intercourse time, mainly including oral medications, local treatments, behavioral techniques, and surgical interventions.

[0004] Oral medications are widely used to treat erectile dysfunction (PE), such as selective serotonin reuptake inhibitors (SSRIs). For example, dapoxetine has been approved for the treatment of PE in many countries. Other SSRIs, such as fluoxetine (US Patent 4,536,518) and paroxetine (US Patent 4,940,731), have also been found to effectively delay ejaculation by modulating serotonin levels in the brain, although these patents primarily focus on their use in treating depression and other conditions. In addition to SSRIs, phosphodiesterase type 5 inhibitors (PDE-5Is), such as sildenafil (Viagra, US Patent 5,250,534), tadalafil (Cialis, US Patent 6,140,329), and vardenafil (Livita, US Patent 6,469,012B1), are also used to treat PE, although researchers primarily focus on their use in treating erectile dysfunction. Tramadol, a weak opioid analgesic, is also used to delay ejaculation. However, these medications may be accompanied by various side effects, such as nausea, dizziness, dry mouth, and decreased libido. Furthermore, not all patients are suitable for using these medications, especially those with cardiovascular, hepatic, or renal complications. This underscores the importance and necessity of developing novel, safe, and effective treatments for PE.

[0005] Topical treatments in the form of anesthetic sprays or ointments are becoming increasingly popular, often containing anesthetics such as lidocaine or benzocaine, which prolong ejaculation time by reducing the sensitivity of the glans penis. However, the timing and method of administration require proper control, meaning that achieving optimal anesthetic distribution on the penis can be challenging. Secondly, overuse of anesthetics can lead to erectile dysfunction or other side effects. Furthermore, the anesthetic effect may extend to the sexual partner, resulting in decreased sexual sensitivity for both partners. There is also a risk of allergic reactions or local skin irritation when using local anesthetics.

[0006] Behavioral techniques, such as the "stop-start" method and the "squeeze" technique, can effectively delay ejaculation, but require practice, communication, and cooperation between partners. However, long-term effects may be limited, and these techniques may not address underlying psychological or physiological factors.

[0007] Although surgical intervention is relatively rare, selective dorsal nerve resection has been explored as a method to reduce penile sensitivity and delay ejaculation. However, the mechanisms of ejaculation in the local penile region have not been elucidated at the molecular biological level; furthermore, the surgery is invasive and irreversible, potentially leading to risks such as paralysis, pain, and erectile dysfunction. The long-term efficacy and safety of this surgical intervention remain controversial. Summary of the Invention

[0008] The technical problem to be solved by the present invention is to provide a hydrogel-coated patch that enables differentiated drug delivery to different areas of the coronal sulcus of the penis, thereby delaying ejaculation, prolonging erection time, and minimizing the impact on sexual pleasure.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A hydrogel-coated patch for delaying ejaculation and prolonging erection time while minimizing the impact on sexual pleasure is characterized by comprising a substrate, a drug-loaded strip, and a hydrogel coating; the substrate is ergonomically designed with a specific curvature to conform to the shape of the coronal sulcus for optimal fit and drug delivery; the drug-loaded strip is arranged on the substrate in two regions: a central region and a lateral region; the central region encapsulates a first drug mixture that promotes the dorsal nerve of the penis; the lateral regions contain a second drug mixture that inhibits the ejaculatory phase; and the hydrogel coating covers the drug-loaded strip to control the continuous release of the drug components.

[0011] Preferably, the right side of the substrate has a tail end with an adjustment hole for adaptive connection with the left tail end of the substrate, allowing free sliding to adapt to different upright and relaxed states.

[0012] Preferably, the substrate adopts a multi-layer composite material structure that integrates breathability, waterproofing, moisture absorption and fixation functions.

[0013] Preferably, the drug loading strip is prepared using materials with good elasticity, flexibility, hydrophilicity, adsorption capacity and biocompatibility.

[0014] Preferably, the first drug mixture contains herbal extracts or Western medicines that promote erection.

[0015] Preferably, the second drug mixture contains herbal extracts or Western medicines that inhibit ejaculation.

[0016] Preferably, a discrete or continuous array of protrusions is provided at the coronal sulcus of the drug loading strip, and the array of protrusions is hemispherical, semi-cylindrical, or semi-conical.

[0017] Preferably, the hydrogel coating is prepared using natural polysaccharides, synthetic polymers, or zwitterionic polymers.

[0018] Preferably, the adjustment hole allows the left tail end to actively slide and adapt to the current size to accommodate changes in the coronal sulcus circumference as the penis transitions from a flaccid to an erect state.

[0019] When using, remove the disposable male hydrogel patch 30 minutes to 12 hours before intercourse. Align the inner side of the central area with the dorsal side of the coronal sulcus, and then, with the penis in a flaccid state, wrap the hemispherical array of protrusions around the penis along the coronal sulcus. Leave the patch in place for at least 30 minutes to allow the natural herbal ingredients to fully penetrate the penile epidermis before removing it.

[0020] The disposable male hydrogel patch of the present invention adopts a multi-angle, multi-level treatment strategy, which comprehensively improves the user's sexual function and quality of life by regulating the nervous system, vascular system and endocrine system. This is the main innovation and advantage of the present invention. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0022] Figure 1 A top view of a hydrogel-coated patch placed flat on a horizontal surface;

[0023] Figure 2 Bottom view of a hydrogel-coated patch laid flat on a horizontal surface;

[0024] Figure 3 A side view of a penis with a hydrogel-coated patch attached;

[0025] Figure 4 A bottom view of a penis with a hydrogel-coated patch, featuring two types of adjustment holes: internal and external.

[0026] Figure 5 The image shows a view of the base of the penis with a hydrogel patch attached; the left image shows the hemispherical protrusion embedded in the coronal sulcus, and the right image shows the structure of the patch packaging. Detailed Implementation

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0029] Example 1:

[0030] like Figures 1 to 5 As shown, this embodiment of the invention provides a hydrogel-coated patch 1000, which can be equipped with two areas: a central area 110 and a side area 120 (the side area 120 can also be used alone as needed). It can prolong male ejaculation, help prolong penile erection time, and has little impact on sexual pleasure.

[0031] The hydrogel-coated patch 1000 includes: a substrate 100 with specific curvatures based on ergonomic design; a drug-carrying strip 105 in different regions, including a central region 110 and side regions 120; a protruding array 130 that is easy to fold in space (or this structure may be absent or replaced by other shapes); a hydrogel coating 400 covering the drug-carrying strip 105 (or this structure may be absent or replaced by other materials); and adjustment holes 160 at both ends for connection (or this structure may be absent).

[0032] 30 minutes to 12 hours before sexual activity, the user removes the disposable hydrogel patch 1000 from the packaging and aligns it with the dorsal side of the patch 1000, located in the center of the coronal sulcus 230, around the hemispherical protrusion array 130 of the penis, wrapping it around the coronal sulcus 230 when the penis is in a flaccid state. When the patch 1000 is tightly fitted to the coronal sulcus 230, the left tail end 140 of the patch is inserted into the adjustment hole 160 of the right tail end 150, adjusting it to a position suitable for the user's penis size. Leave it in place for at least 30 minutes to allow the natural herbal ingredients 300 to fully diffuse into the penile epidermis, then remove the patch 1000.

[0033] In this invention, the adjustment hole 160 on the right tail end 150 of the patch allows the left tail end 140 to actively slide and adapt to the current size, thereby accommodating the change in coronal sulcus circumference as the penis transitions from a flaccid to an erect state. Due to the adhesive properties of the hydrogel itself and the ability of the internal protruding structure to embed into the curved grooves of the coronal sulcus, the risk of patch displacement is reduced. This sliding structure can be represented as an embedded type 1100 and an externally embedded type 1200. The embedded type 1100 is cut directly to the right tail end 150, while the externally embedded type 1200 is sewn onto the right tail end 150.

[0034] The patch 1000 of the present invention may further include the following end-connection designs: double-sided adhesive, shape memory metal, magnetic attraction, Velcro connection, button or hook and loop fastener, zipper, knot, belt, etc. Compared to the adjustment hole 160, these designs have the disadvantage of higher cost or difficulty in automatically adapting to changes in the coronal sulcus circumference caused by erection. It should be emphasized that even without the end-connection structure, the coronal sulcus patch of the present invention can still adhere to the surface of the penis. Therefore, the scope of protection of the present invention covers all the aforementioned end-connection designs and designs without connection. Any coronal sulcus patch employing one or more of these designs, or variations or combinations thereof, falls within the scope of protection of this patent.

[0035] According to a preferred embodiment of the present invention, the substrate 100 may employ a multi-layer composite material structure, integrating breathability, waterproofing, moisture absorption, and fixation functions. In some embodiments, the substrate 100 may be made of materials such as polyurethane film, non-woven fabric, pressure-sensitive adhesive, release paper, or mesh polyethylene film. The right tail ends 150 and 100 of the substrate include adjustment holes 160. To better conform to the coronal sulcus, the upper and lower edge curves of the substrate 100 adopt an ergonomic design. Specifically, the present invention employs a computer-simulated discrete differential geometry method to flatten the three-dimensional modeled coronal sulcus surface onto a two-dimensional plane.

[0036] To obtain a base shape that better fits the coronal sulcus 230. In some embodiments, the total length of the substrate 100 is approximately 6-9 cm. In some embodiments, the total length of the substrate 100 is approximately 9-12 cm. In some embodiments, the total length of the substrate 100 is approximately 12-15 cm.

[0037] The drug carrier 105 is made of a material with good elasticity and flexibility, hydrophilicity, absorbency, and biocompatibility, such as special textile cotton, medical absorbent cotton, and viscous fibers. The hydrogel material is a material such as chitosan, demethylated cellulose, or a mixture of hydrogel materials. The drug carrier 105 is divided into a central zone 110 and lateral zones 120. The central zone 110 covers a large number of dorsomedial branches of the dorsal nerve of the penis (DNP), which have been shown to be closely related to erection. By encapsulating the drug mixture 310 in the central zone 110, the dorsal nerve can be promoted, thereby enhancing erection. The lateral zone 120 covers a small number of dorsomedial branches of the DNP and a large number of lateral branches of the DNP associated with ejaculation. By loading the drug mixture 320 into the lateral zone 120, premature ejaculation can be inhibited. In some embodiments, the drug mixture 310 in the central zone contains natural herbal ingredients or pharmaceutical ingredients that promote the dorsal nerve of the penis.

[0038] The drug mixture 320 in the lateral zone of this invention works in coordination with the drug mixture 310 in the central zone, comprehensively improving the user's sexual function and inhibiting premature ejaculation from multiple aspects, including the nervous, vascular, and endocrine systems. This multi-angle, multi-level treatment strategy is the main innovation and advantage of this invention.

[0039] In some embodiments, the gap 110 between the central region drug loading strips and the side region drug loading strips 120 are within 6 mm. In some embodiments, there is no separation design between the central region drug loading strip 110 and the side region drug loading strips 120.

[0040] In some embodiments, the drug delivery strip 100 includes a protruding array 160 located in the coronal sulcus depression. This protruding array is typically discrete rather than continuous, with common types including hemispherical arrays, hemispherical arrays, smooth hemiconical arrays, etc. This array serves three purposes. First, the protruding structure better adapts to the coronal sulcus depression, resulting in more uniform and controllable drug diffusion. Second, the discontinuous discrete design eliminates wrinkles that might result from continuous protruding structures and prevents concentration gradients caused by wrinkles during patch 1000 bending. Finally, this 3D embedded structure helps reduce the risk of patch 1000 displacement, thereby ensuring that the central region 110 can continuously optimize the effect on the dorsal penile nerve. In some embodiments, the protruding array may be a hemispherical protruding array 160. Due to the isotropic geometry of a sphere, the hemispherical array 160 has optimal spatial flexibility. In some embodiments, the drug delivery strip 100 does not include the protruding array 160. In some embodiments, the drug loading strip 100 is loaded with a hydrogel 400 exhibiting excellent extensibility, high hydrophilicity, and temperature sensitivity, enabling controlled and uniform release through appropriate affinity with the drug components. This hydrogel coating can achieve uniform or slow release of the drug mixture 300, thereby reducing skin irritation. The hydrogel material may include natural polysaccharides, synthetic polymers, and zwitterionic polymers.

[0041] In some embodiments, the hydrogel 400 may be selected from natural polysaccharides, including chitin and its derivatives, such as chitosan, carboxymethyl chitosan, etc. In some embodiments, the hydrogel 400 may be selected from alginates, such as sodium alginate, calcium alginate, etc. In some embodiments, the hydrogel 400 may be selected from natural macromolecular proteins, such as silk fibroin. In some embodiments, the hydrogel 400 may be selected from hyaluronic acid and its derivatives. In some embodiments, the hydrogel 400 may be selected from cellulose and its derivatives, such as hydroxypropyl cellulose, sodium carboxymethyl cellulose, etc. In some embodiments, the hydrogel 400 may be selected from natural macromolecular proteins, such as silk fibroin. In some embodiments, the hydrogel 400 may be selected from synthetic polymers, including polyacrylamide (PAM) and its derivatives, such as NIPAM. In some embodiments, the hydrogel 400 may be selected from natural macromolecular proteins, such as silk fibroin. In some embodiments, the hydrogel 400 may be selected from zwitterionic polymers, including gelatin-chitosan composites, chitosan-hyaluronic acid composites, and chitosan-polyaspartic acid composites.

[0042] In some embodiments, the drug carrier 100 includes a very small amount of hydrogel coating 400. In some embodiments, the drug carrier 100 does not include a hydrogel coating 400.

[0043] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made to the technical solutions of the present invention by those skilled in the art without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A hydrogel-coated patch for delaying ejaculation and prolonging erection time while minimizing the impact on sexual pleasure, characterized in that, Includes substrate, drug-loaded strip, and hydrogel coating; The substrate is ergonomically designed with a specific curvature to conform to the shape of the coronal sulcus for optimal fit and drug delivery. A drug-loaded strip is arranged on the substrate in two regions: a central region and a lateral region. The central region encapsulates a first drug mixture that promotes the dorsal nerve of the penis. The lateral regions contain a second drug mixture that inhibits the ejaculation phase. A hydrogel coating covers the drug-loaded strip to control the continuous release of the drug components.

2. The hydrogel-coated patch according to claim 1, characterized in that, The right side of the substrate has a tail end with an adjustment hole for adaptive connection with the left tail end of the substrate.

3. The hydrogel-coated patch according to claim 2, characterized in that, The substrate adopts a multi-layer composite material structure that integrates breathability, waterproofing, moisture absorption and fixation functions.

4. The hydrogel-coated patch according to claim 3, characterized in that, The drug-loaded strips are prepared using materials with good elasticity, flexibility, hydrophilicity, adsorption capacity, and biocompatibility.

5. The hydrogel-coated patch according to claim 4, characterized in that, The first drug mixture contains herbal extracts or Western medicines that promote erection.

6. The hydrogel-coated penile patch for prolonging sexual intercourse as described in claim 5, characterized in that, The second drug mixture contains herbal extracts or Western medicines that inhibit ejaculation.

7. The hydrogel-coated patch according to claim 6, characterized in that, Discrete or continuous arrays of protrusions are provided in the coronal sulcus of the drug loading strip, and the arrays of protrusions are hemispherical, semi-cylindrical, or semi-conical.

8. The hydrogel-coated patch according to claim 7, characterized in that, Hydrogel coatings are prepared using natural polysaccharides, synthetic polymers, or zwitterionic polymers.

9. The hydrogel-coated patch according to claim 8, characterized in that, The adjustment hole allows the left tail end to actively slide and adapt to the current size, accommodating changes in the coronal sulcus circumference as the penis transitions from a flaccid to an erect state.

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