Preparation method of fried aspongopus formula granules and prepared fried aspongopus formula granules

Abstract

The invention provides a preparation method of fried aspongopus formula granules and the fried aspongopus formula granules prepared by the preparation method, and relates to the technical field of traditional Chinese medicine processing. The preparation method of the fried aspongopus formula granules comprises the following steps: firstly, putting fried aspongopus decoction pieces into a container, decocting and extracting, and concentrating into a concentrated solution with the relative density of 1.01-1.05 g / mL after extraction; adding wood powder charcoal and beta-cyclodextrin into the concentrated solution, uniformly mixing, sequentially centrifuging and spray-drying to obtain spray-dried powder, sieving and mixing to obtain dry paste powder, and performing dry granulation on the dry paste powder to obtain the fried aspongopus formula granules. According to the preparation method disclosed by the invention, on the basis of preparing the fried aspongopus formula granules through water extraction and decoction, wood powder charcoal and beta-cyclodextrin are added into a concentrated solution. Through verification, the prepared fried aspongopus formula granules can effectively avoid the problem that aflatoxin in the existing fried aspongopus formula granules exceeds the standard under the condition of ensuring that the content index is not reduced.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine processing technology, and in particular to a method for preparing stir-fried *Corydalis yanhusuo* (a type of insect) formula granules and the resulting stir-fried *Corydalis yanhusuo* formula granules. Background Technology

[0002] Nine-fragrant insect (scientific name: Chinese Corydius Stink bugs (also known as stink bugs or stink beetles) are insects belonging to the family Astrophytum and the genus Astrophytum. Traditional Chinese medicine believes that the whole roasted and dried stink bug (roasted stink bug) can be used medicinally. It is warm in nature and salty in taste, and has the effects of regulating qi and relieving pain, warming the middle jiao and tonifying yang.

[0003] With the development of the times and the continuous progress of science and technology, traditional Chinese medicine decoction pieces are also changing, leading to the emergence of new types of Chinese medicine decoction pieces, one of which is Chinese medicine formula granules. Chinese medicine formula granules, also known as "single-herb concentrated granules," "new-type granular Chinese medicine decoction pieces," or "pre-prepared decoction pieces," are a series of pure Chinese medicine products made from Chinese medicine decoction pieces that meet processing standards, extracted, concentrated, dried, and granulated using modern processes. In recent years, they have been widely used in the field of traditional Chinese medicine. However, the production of existing *Nine-Fragrance Insect* (a type of insect) Chinese medicine formula granules has certain problems, namely, the stir-fried *Nine-Fragrance Insect* formula granules produced using existing production processes have been found to contain excessive levels of aflatoxin.

[0004] Therefore, it is both necessary and urgent to research and develop a preparation method for stir-fried stink bug formula granules, in order to solve the problem of excessive aflatoxin in existing stir-fried stink bug formula granule products while ensuring stable quality indicators.

[0005] In view of this, the present invention is hereby proposed. Summary of the Invention

[0006] The first objective of this invention is to provide a method for preparing stir-fried stink bug formula granules. The method, based on the preparation of stir-fried stink bug formula granules by water extraction and decoction, effectively removes aflatoxin from the medicinal solution by adding lignocarbon powder and betacyclodextrin to the concentrated solution.

[0007] The second objective of this invention is to provide a formula granule for stir-fried nine-fragrant insects.

[0008] In order to achieve the above-mentioned objectives of the present invention, the following technical solution is adopted: This invention provides a method for preparing stir-fried nine-fragrant insect formula granules, the preparation method comprising: (A) The stir-fried nine-fragrant insect slices were placed in a container for decoction and extraction. The decoction was then concentrated to a concentration with a relative density of 1.01~1.05 g / mL. (B) Add wood charcoal powder and beta-cyclodextrin to the concentrate and mix evenly. Then, centrifuge and spray dry to obtain spray-dried powder. After sieving and mixing, dry paste powder is obtained. Dry paste powder is then granulated to obtain the granules of the stir-fried nine-fragrant insect formula.

[0009] Furthermore, the method for decoction extraction in step (A) includes: Weigh out the stir-fried nine-fragrant insect slices and place them in a container. Add 10 to 12 times the amount of water and decoct for 1 to 1.5 hours. Filter the mixture. Add 7 to 9 times the amount of water to the residue and decoct for 0.5 to 0.8 hours. Filter the mixture and combine the two extracts to obtain the decoction extract.

[0010] Furthermore, in step (A), the concentration process utilizes a double-effect concentrator to concentrate the decoction extract, wherein: Temperature: 75~85℃ for the first effect, 65~75℃ for the second effect; Vacuum degree: -0.07~-0.03MPa for single effect, -0.08~-0.06MPa for double effect.

[0011] Furthermore, in step (B), the amount of wood-based charcoal powder added is 5-8% of the mass of the stir-fried worm slices.

[0012] Furthermore, in step (B), the amount of beta-cyclodextrin added is 5-8% of the mass of the stir-fried *Corydalis yanhusuo* slices.

[0013] Furthermore, the drying process parameters for spray drying in step (B) are as follows: Steam temperature after steaming is 140~170℃, air inlet temperature is 175~185℃, material conveying temperature is 45~60℃, blower frequency is 35~45HZ, induced draft frequency is 40~50HZ, and atomization frequency conversion is 30~45HZ.

[0014] Furthermore, the particle size of the spray-dried powder in step (B) is that of powder that has passed through an 80-mesh sieve.

[0015] Furthermore, the dry granulation method in step (B) includes: The spray-dried powder was mixed with magnesium stearate and maltodextrin to obtain a dry paste powder, which was then processed into fried nine-fragrant insect formula granules by a dry granulation machine.

[0016] Furthermore, the hydraulic cylinder pressure of the dry granulator is 5~20MPa, the feeding speed is 25~150rpm, the tableting speed is 8~40rpm, and the granulation speed is 80~120rpm. Preferably, the particle size of the granulation screen of the dry granulator is 12 mesh or 30 mesh.

[0017] The present invention provides a granule of stir-fried nine-fragrant insects prepared by the above preparation method.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a method for preparing stir-fried stink bug formula granules. The method involves first decocting and extracting stir-fried stink bug slices in a container, then concentrating the extract to a relative density of 1.01-1.05 g / mL. Subsequently, charcoal powder and beta-cyclodextrin are added to the concentrate and mixed thoroughly. The mixture is then centrifuged and spray-dried to obtain a spray-dried powder. After sieving and mixing, a dry extract powder is obtained. This dry extract powder is then granulated to obtain stir-fried stink bug formula granules. This method, based on the water extraction and decoction preparation of stir-fried stink bug formula granules, effectively removes aflatoxin from the decoction by adding charcoal powder and beta-cyclodextrin to the concentrate. Verification shows that the stir-fried stink bug formula granules prepared using this method can purify and separate aflatoxin from the decoction while ensuring that the content and other quality indicators do not decrease, effectively avoiding the problem of excessive aflatoxin levels found in existing stir-fried stink bug formula granules.

[0019] The stir-fried stink bug formula granules prepared by the method provided by this invention ensure the quality indicators such as the content of effective ingredients (1,4-dihydro-4-oxoquinoline-2-carboxylic acid per 1g) 10 If the aflatoxin in the liquid does not decrease from 2.0 mg to 7.0 mg (H7NO3), the aflatoxin in the liquid is purified and separated to ensure that the prepared stir-fried glutinous insect formula granules do not exceed the aflatoxin limit. Detailed Implementation

[0020] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] It should be noted that the "Technical Requirements for Quality Control and Standard Formulation of Traditional Chinese Medicine Formula Granules (Draft for Comments)" issued by the National Medical Products Administration stipulates that the preparation of traditional Chinese medicine formula granules, except for the molding process, should be basically consistent with traditional decoctions, that is, extraction using water as the solvent, and production using physical methods for solid-liquid separation, concentration, drying, and granulation. Therefore, the extraction solvent for the stir-fried stink bug formula granules is drinking water. This application has found in long-term production practice that, due to the characteristics of the stir-fried stink bug raw material itself, formula granules prepared by water extraction and decoction methods often have the problem of excessive aflatoxin levels.

[0022] In view of this, according to one aspect of the present invention, the present invention provides a method for preparing stir-fried nine-fragrant insect formula granules, the preparation method comprising: (A) The stir-fried nine-fragrant insect slices were placed in a container for decoction and extraction. The decoction was then concentrated to a concentration with a relative density of 1.01~1.05 g / mL. (B) Add wood charcoal powder and beta-cyclodextrin to the concentrate and mix evenly. Then, centrifuge and spray dry to obtain spray-dried powder. After sieving and mixing, dry paste powder is obtained. Dry paste powder is then granulated to obtain the granules of the stir-fried nine-fragrant insect formula.

[0023] The decoction extraction is a water extraction decoction extraction, and the decoction is performed using purified water or drinking water.

[0024] The present invention provides a method for preparing stir-fried stink bug formula granules. Based on the water extraction and decoction preparation of stir-fried stink bug formula granules, this method effectively removes aflatoxin from the medicinal solution by adding lignocellulosic charcoal and betacyclodextrin to the concentrated solution. Verification has shown that the stir-fried stink bug formula granules prepared using the method of this application can purify and separate aflatoxin from the medicinal solution while ensuring that the content and other quality indicators do not decrease, effectively avoiding the problem of excessive aflatoxin levels present in existing water extraction and decoction preparations of stir-fried stink bug formula granules.

[0025] In a preferred embodiment of the present invention, the method of step (A) decoction extraction includes: weighing the stir-fried nine-fragrant insect slices and placing them in a container, adding 10 to 12 times the amount of water, decoct and extract for 1 to 1.5 hours, and filtering; adding 7 to 9 times the amount of water to the residue, decoct and extract for 0.5 to 0.8 hours, filtering, and combining the secondary extracts to obtain the decoction extract.

[0026] In a preferred embodiment of the present invention, step (A) concentration uses a double-effect concentrator to concentrate the decoction extract, wherein: Temperature: 75~85℃ for the first effect, 65~75℃ for the second effect; Vacuum degree: -0.07~-0.03MPa for single effect, -0.08~-0.06MPa for double effect.

[0027] As a preferred embodiment, the above-described method of concentrating the decoction extract using a double-effect concentrator can effectively lower the boiling point and reduce the influence of temperature-sensitive components.

[0028] In a preferred embodiment of the present invention, the amount of wood-based charcoal powder added in step (B) is 5-8% of the mass of the stir-fried worm slices.

[0029] In a preferred embodiment, the wood-based activated carbon in this application is wood-based powdered activated carbon.

[0030] Preferably, the particle size (mesh count) of the wood-based powdered activated carbon is 200 mesh.

[0031] In a preferred embodiment of the present invention, the amount of beta-cyclodextrin added in step (B) is 5-8% of the mass of the stir-fried *Corydalis yanhusuo* slices.

[0032] In a preferred embodiment of the present invention, the drying process parameters for step (B) spray drying are as follows: Steam temperature after steaming is 140~170℃, air inlet temperature is 175~185℃, material conveying temperature is 45~60℃, blower frequency is 35~45HZ, induced draft frequency is 40~50HZ, and atomization frequency conversion is 30~45HZ.

[0033] In a preferred embodiment of the present invention, the particle size of the spray-dried powder in step (B) is powder that passes through an 80-mesh sieve.

[0034] In a preferred embodiment of the present invention, the method of dry granulation in step (B) includes: mixing spray-dried powder with magnesium stearate and maltodextrin to obtain dry powder, and preparing fried nine-fragrant insect formula granules by dry granulation machine.

[0035] Preferably, the dry granulation method includes: mixing 0.02% magnesium stearate and a corresponding amount of maltodextrin with the sieved and sprayed dry powder, setting the mixing speed to 10 rpm and the mixing time to 30 min; wherein: the amount of maltodextrin added = the total amount of raw materials × 10.0% - the amount of powder sprayed after crushing and sieving - the amount of wood charcoal powder - the amount of betacyclodextrin - the amount of magnesium stearate.

[0036] In a preferred embodiment of the present invention, the hydraulic cylinder pressure of the dry granulator is 5~20MPa, the feeding speed is 25~150rpm, the tableting speed is 8~40rpm, and the granulation speed is 80~120rpm. Preferably, the particle size of the granulation screen of the dry granulator is 12 mesh or 30 mesh.

[0037] According to one aspect of the present invention, a granule of stir-fried nine-fragrant insects prepared by the above-described preparation method is provided.

[0038] The preparation method provided by this invention produces stir-fried stink bug formula granules that, while ensuring that the content of effective ingredients does not decrease, purifies and separates aflatoxin in the medicinal solution, ensuring that the prepared stir-fried stink bug formula granules do not exceed the aflatoxin limit.

[0039] The technical solution of the present invention will be further described below with reference to the embodiments.

[0040] Example 1 A method for preparing stir-fried nine-fragrant insect formula granules, the preparation method comprising: 1. Weigh out the stir-fried nine-fragrant insect slices and place them in a container. Add 11 times the amount of water and decoct for 1.2 hours. Filter. Add 8 times the amount of water to the residue and decoct for 0.6 hours. Filter. Combine the two extracts to obtain the decoction extract.

[0041] 2. The decoction extract was concentrated using a double-effect concentrator to obtain a concentrate with a relative density of 1.01~1.05 g / mL. The parameters for the dual-effect concentration are: temperature: 80℃ for the first effect and 70℃ for the second effect; vacuum: -0.05MPa for the first effect and -0.07MPa for the second effect.

[0042] 3. Add 5.0% of the weight of the medicinal slices of wood charcoal powder and 5% of the weight of the medicinal slices of betacyclodextrin to the concentrate. Based on the volume of the concentrate after adding the excipients, control the temperature of the mixing tank at 85℃ and keep the stirrer running continuously for 30 minutes. Then, centrifuge and filter the concentrate (7000 rpm, 15 minutes, and pass the centrifuged liquid through a 350-mesh sieve) to obtain the filtrate. The particle size (mesh count) of the wood-based powdered activated carbon is 200 mesh.

[0043] 4. Spray dry the filtrate to obtain spray-dried powder that passes through an 80-mesh sieve. After sieving and mixing the spray-dried powder, obtain dry paste powder, which is then dry-granulated to obtain granules that pass through a 12-mesh sieve, thus obtaining the granules for the stir-fried nine-fragrant insect formula. The drying process parameters for the spray drying are as follows: steam temperature 150℃, air inlet temperature 180℃, material conveying temperature 50℃, blower frequency 40HZ, induced draft frequency 45HZ, and atomization frequency conversion 40HZ.

[0044] The dry granulation method includes: adding 0.02% (by weight of medicinal slices) of magnesium stearate and maltodextrin to the spray-dried powder after passing through an 80-mesh sieve and mixing (mixing speed 10 rpm, mixing time 30 min); installing a 12-mesh sieve on the dry granulator, and adjusting the main hydraulic cylinder pressure, roller speed, and feeding screw speed parameters for granulation. The amount of maltodextrin added = total amount of medicinal slices × 10.0% - amount of spray-dried powder after pulverization and sieving - amount of wood charcoal powder - amount of betacyclodextrin - amount of magnesium stearate.

[0045] The control cylinder pressure is 15MPa, the feeding speed is 100rpm, the tableting speed is 30rpm, and the granulation speed is 100rpm.

[0046] Example 2 A method for preparing stir-fried nine-fragrant insect formula granules, the preparation method comprising: 1. Weigh out the stir-fried nine-fragrant insect slices and place them in a container. Add 10 times the amount of water and decoct for 1 hour. Filter. Add 7 times the amount of water to the residue and decoct for 0.5 hours. Filter. Combine the two extracts to obtain the decoction extract.

[0047] 2. The decoction extract was concentrated using a double-effect concentrator to obtain a concentrate with a relative density of 1.01~1.05 g / mL. The parameters for the dual-effect concentration are: temperature: 85℃ for the first effect and 75℃ for the second effect; vacuum: -0.03 MPa for the first effect and -0.06 MPa for the second effect.

[0048] 3. Add 5.0% of the weight of the medicinal slices of wood charcoal powder and 5% of the weight of the medicinal slices of betacyclodextrin to the concentrate. Based on the volume of the concentrate after adding the excipients, control the temperature of the mixing tank at 75℃ and keep the stirrer running continuously for 30 minutes. Then, centrifuge and filter the concentrate (7000 rpm, 15 minutes, and pass the centrifuged liquid through a 350-mesh sieve) to obtain the filtrate. 4. Spray dry the filtrate to obtain spray-dried powder that passes through an 80-mesh sieve. After sieving and mixing the spray-dried powder, obtain dry paste powder, which is then dry-granulated to obtain granules that pass through a 12-mesh sieve, thus obtaining the granules for the stir-fried nine-fragrant insect formula. The drying process parameters for the spray drying are as follows: steam temperature 170℃, air inlet temperature 175℃, material conveying temperature 60℃, blower frequency 45HZ, induced draft frequency 50HZ, and atomization frequency conversion 45HZ.

[0049] The dry granulation method includes: adding 0.02% magnesium stearate and a corresponding amount of maltodextrin to the dry powder after passing through an 80-mesh sieve, and mixing (mixing speed 10 rpm, mixing time 30 min); installing a 12-mesh sieve on the dry granulator, and adjusting the main cylinder pressure, roller speed, and feeding screw speed parameters for granulation. The amount of maltodextrin added = total amount of raw materials × 10.0% - amount of powder sprayed after pulverization and sieving - amount of wood charcoal powder - amount of betacyclodextrin - amount of magnesium stearate.

[0050] The control cylinder pressure is 20MPa, the feeding speed is 150rpm, the tableting speed is 40rpm, and the granulation speed is 120rpm.

[0051] Example 3 A method for preparing stir-fried nine-fragrant insect formula granules, the preparation method comprising: 1. Weigh out the stir-fried nine-fragrant insect slices and place them in a container. Add 12 times the amount of water and decoct for 1.5 hours. Filter. Add 9 times the amount of water to the residue and decoct for 0.8 hours. Filter. Combine the two extracts to obtain the decoction extract.

[0052] 2. The decoction extract was concentrated using a double-effect concentrator to obtain a concentrate with a relative density of 1.01~1.05 g / mL. The parameters for the dual-effect concentration are: temperature: 75℃ for the first effect and 65℃ for the second effect; vacuum: -0.07 MPa for the first effect and -0.08 MPa for the second effect.

[0053] 3. Add 5.0% of the weight of the medicinal slices of wood charcoal powder and 5% of the weight of the medicinal slices of betacyclodextrin to the concentrate. Based on the volume of the concentrate after adding the excipients, control the temperature of the mixing tank at 95℃ and keep the stirrer running continuously for 30 minutes. Then, centrifuge and filter the concentrate (7000 rpm, 15 minutes, and pass the centrifuged liquid through a 350-mesh sieve) to obtain the filtrate. 4. Spray dry the filtrate to obtain spray-dried powder that passes through an 80-mesh sieve. After sieving and mixing the spray-dried powder, obtain dry paste powder, which is then dry-granulated to obtain granules that pass through a 12-mesh sieve, thus obtaining the granules for the stir-fried nine-fragrant insect formula. The drying process parameters for the spray drying are as follows: steam temperature 140℃, air inlet temperature 185℃, material conveying temperature 45℃, blower frequency 35HZ, induced draft frequency 40HZ, and atomization frequency conversion 30HZ.

[0054] The dry granulation method includes: adding 0.02% magnesium stearate and a corresponding amount of maltodextrin to the dry powder after passing through an 80-mesh sieve, and mixing (mixing speed 10 rpm, mixing time 30 min); installing a 12-mesh sieve on the dry granulator, and adjusting the main cylinder pressure, roller speed, and feeding screw speed parameters for granulation. The amount of maltodextrin added = total amount of raw materials × 10.0% - amount of powder sprayed after pulverization and sieving - amount of wood charcoal powder - amount of betacyclodextrin - amount of magnesium stearate.

[0055] The control cylinder pressure is 5MPa, the feeding speed is 25rpm, the tableting speed is 8rpm, and the granulation speed is 80rpm.

[0056] Comparative Example 1 This comparative example, excluding step 3, is as follows: "Add 5% of the amount of the medicinal slices of beta-cyclodextrin to the concentrate. Based on the amount of concentrate after adding the excipients, control the temperature of the mixing tank to 95°C and keep the stirring constantly running. Maintain stirring for 30 minutes and then use a centrifuge to filter and obtain the filtrate." The rest is the same as in Example 1.

[0057] That is, the difference between this comparative example and Example 1 is that no wood charcoal powder is added in this comparative example.

[0058] Comparative Example 2 This comparative example is the same as Example 1, except that the "wood powdered carbon" in step 3 is replaced with an equal amount of "multi-walled carbon nanotubes".

[0059] Comparative Example 3 This comparative example is the same as Example 1, except that the "wood powder charcoal" in step 3 is replaced with an equal amount of "glucomannan".

[0060] Comparative Example 4 In this comparative example, except that "wood powder charcoal" in step 3 is replaced with an equal amount of "montmorillonite powder", the rest is the same as in Example 1.

[0061] Comparative Example 5 In this comparative example, except that "wood powder charcoal" in step 3 is replaced with an equal amount of "aluminum silicate", the rest is the same as in Example 1.

[0062] Comparative Example 6 In this comparative example, except that the addition amount of wood powder charcoal in step 3 is 10%, the rest is the same as in Example 1.

[0063] Comparative Example 7 In this comparative example, except that the addition amount of wood powder charcoal in step 3 is 3%, the rest is the same as in Example 1.

[0064] Comparative Example 8 In this comparative example, except that the addition amount of beta - cyclodextrin in step 3 is 10%, the rest is the same as in Example 1.

[0065] Comparative Example 9 In this comparative example, except that the addition amount of beta - cyclodextrin in step 3 is 3%, the rest is the same as in Example 1.

[0066] Experimental Example 1 To show that the prepared fried Aspongopus formula granules of this application can purify and separate aflatoxin in the medicinal liquid and effectively avoid the problem of excessive aflatoxin in the existing fried Aspongopus formula granules while ensuring that the quality indexes do not decline. Now, the fried Aspongopus formula granules prepared in Examples 1 - 3 and Comparative Examples 1 - 9 are detected.

[0067] The specific detection method refers to the Guangdong Provincial Quality Standard for Traditional Chinese Medicine Formula Granules: Fried Aspongopus Formula Granules Yue PFKL20230035.

[0068] The specific detection results are shown in the following table:

[0069] As can be seen from the above table, the adsorption and removal rate of aflatoxin in the fried Aspongopus formula granules prepared in Examples 1 - 3 of this application can reach 100%, ensuring that the prepared fried Aspongopus formula granules do not have the problem of excessive aflatoxin. At the same time, the content of 1,4 - dihydro - 4 - oxo - quinoline - 2 - carboxylic acid (C 10 H7NO3) per 1 g is 4.94 - 5.33 mg, which can fully meet the requirements of the active ingredients in the fried Aspongopus formula granules.

[0070] Comparative Example 1 is an implementation method without adding an adsorbent, and its aflatoxin is significantly exceeded.

[0071] Comparative Examples 2 to 5 are embodiments of the present invention that examine other adsorbents. As can be seen from the above, compared with the "wood powder charcoal" of this application, the treatment effect of other adsorbents is poor and they cannot achieve the effect of completely removing aflatoxin.

[0072] Comparative Examples 6-9 are embodiments of the present invention that investigate the amount of "wood-based charcoal powder and beta-cyclodextrin" added. Specifically: In Comparative Example 6, the addition of 10% wood-based charcoal powder significantly reduced the content of effective substances; in Comparative Example 7, the addition of 3% wood-based charcoal powder did not completely remove aflatoxin; in Comparative Example 8, the addition of 10% thiacyclodextrin, and in Comparative Example 9, the addition of 3% thiacyclodextrin resulted in poor flocculation and low yield, leading to a decrease in effective content.

[0073] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for preparing stir-fried nine-fragrant insect formula granules, characterized in that, The preparation method includes: (A) The stir-fried nine-fragrant insect slices were placed in a container for decoction and extraction. The decoction was then concentrated to a concentration with a relative density of 1.01~1.05 g / mL. (B) Add wood charcoal powder and beta-cyclodextrin to the concentrate and mix evenly. Then, centrifuge and spray dry to obtain spray-dried powder. After sieving and mixing, dry paste powder is obtained. Dry paste powder is then granulated to obtain the granules of the stir-fried nine-fragrant insect formula.

2. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, The method for decoction extraction in step (A) includes: Weigh out the stir-fried nine-fragrant insect slices and place them in a container. Add 10 to 12 times the amount of water and decoct for 1 to 1.5 hours. Filter the mixture. Add 7 to 9 times the amount of water to the residue and decoct for 0.5 to 0.8 hours. Filter the mixture and combine the two extracts to obtain the decoction extract.

3. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, Step (A) concentration uses a double-effect concentrator to concentrate the decoction extract, wherein: Temperature: 75~85℃ for the first effect, 65~75℃ for the second effect; Vacuum degree: -0.07~-0.03MPa for single effect, -0.08~-0.06MPa for double effect.

4. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, In step (B), the amount of wood-based charcoal powder added is 5-8% of the mass of the stir-fried *Corydalis yanhusuo* (a type of worm) slices.

5. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, In step (B), the amount of beta-cyclodextrin added is 5-8% of the mass of the stir-fried *Corydalis yanhusuo* slices.

6. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, The drying process parameters for spray drying in step (B) are as follows: Steam temperature after steaming is 140~170℃, air inlet temperature is 175~185℃, material conveying temperature is 45~60℃, blower frequency is 35~45HZ, induced draft frequency is 40~50HZ, and atomization frequency conversion is 30~45HZ.

7. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, The particle size of the spray-dried powder in step (B) is that of powder that passes through an 80-mesh sieve.

8. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 1, characterized in that, The method for dry granulation in step (B) includes: The spray-dried powder was mixed with magnesium stearate and maltodextrin to obtain a dry paste powder, which was then processed into fried nine-fragrant insect formula granules by a dry granulation machine.

9. The method for preparing the stir-fried nine-fragrant insect formula granules according to claim 8, characterized in that, The hydraulic cylinder pressure of the dry granulator is 5~20MPa, the feeding speed is 25~150rpm, the tableting speed is 8~40rpm, and the granulation speed is 80~120rpm. Preferably, the particle size of the granulation screen of the dry granulator is 12 mesh or 30 mesh.

10. A granule of stir-fried nine-fragrant insects prepared by the preparation method according to any one of claims 1 to 9.

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