Medicinal and edible composition for promoting spleen and stomach absorption, clearing heat and moistening intestines

Abstract

The present invention relates to the technical field of pharmaceutical compositions, and particularly discloses a spleen and stomach absorption promoting heat clearing intestine moistening medicinal and edible composition, which comprises fried hawthorn, fried malt, raw Chinese yam, poria cocos, dried orange peel, fried semen raphani, fried endothelium corneum gigeriae galli, agastache rugosus, polygonatum odoratum, dendrobe, fried white hyacinth bean, jujube, dark plum, and dandelion root. The fried hawthorn, the fried malt and the fried endothelium corneum gigeriae galli are used for promoting digestion and removing food stagnation, the raw Chinese yam and the poria cocos are used for invigorating spleen and replenishing qi, the dandelion root and the radix polygonati officinalis are used for clearing heat and nourishing yin, and the fried semen raphani and the smoked plum are used for moistening intestines and relaxing bowel, so that the double effects of invigorating spleen and assisting transportation and clearing heat and Experiments show that the traditional Chinese medicine composition can remarkably improve the gastric emptying rate and the small intestine propulsion rate, reduce the inflammatory factor level, improve the intestinal absorption capacity and fundamentally improve the problems of weakness of the spleen and the stomach and dryness-heat of the intestinal tract.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical composition technology, specifically relating to a food-medicine homologous composition that promotes spleen and stomach absorption, clears heat and moistens the intestines. Background Art

[0002] With the changes in dietary structure and the fast pace of life in modern society, problems such as weak spleen and stomach, indigestion, intestinal dryness and heat and constipation are becoming increasingly common. Traditional Chinese medicine believes that the spleen and stomach are the foundation of postnatal health. Dysfunction of the spleen and stomach can lead to obstructed food transportation and transformation, internal generation of damp heat, and in turn cause symptoms such as abdominal distension, loss of appetite and difficulty in defecation.

[0003] Currently, the solutions on the market for this type of problem include chemical drugs and traditional Chinese medicine compound prescriptions. However, some traditional Chinese medicine compound prescriptions have biased drug properties and often focus on a single symptom, making it difficult to achieve both symptomatic and root cause treatment. Summary of the Invention

[0004] The purpose of this invention is to provide a food-medicine composition that promotes spleen and stomach absorption, clears heat and moistens the intestines, in order to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A food-grade medicinal composition that promotes spleen and stomach absorption, clears heat, and moistens the intestines, is composed of the following raw materials in parts by weight:

[0007] 10-15g of stir-fried hawthorn, 7-11g of stir-fried malt, 3-7g of raw yam, 3-7g of poria cocos, 3-7g of dried tangerine peel, 10-15g of stir-fried radish seeds, 4-8g of stir-fried chicken gizzard lining, 1-3g of agastache rugosa, 2-4g of polygonatum odoratum, 1-3g of dendrobium, 2-4g of stir-fried white hyacinth bean, 1-3g of jujube, 0.5-1.5g of dried plum, and 1-3g of dandelion root.

[0008] Preferably, the weight parts of each raw material are as follows:

[0009] 12g of stir-fried hawthorn, 9g of stir-fried malt, 5g of raw yam, 5g of poria cocos, 5g of dried tangerine peel, 12g of stir-fried radish seeds, 6g of stir-fried chicken gizzard lining, 2g of agastache rugosa, 3g of polygonatum odoratum, 2g of dendrobium, 3g of stir-fried white hyacinth bean, 2g of jujube, 1g of dried plum, and 2g of dandelion root.

[0010] Preferably, the dosage form of the composition is powder, granules, capsules, tablets, or oral administration.

[0011] Preferably, the method for preparing the powder includes the following steps:

[0012] S1. Grind the stir-fried hawthorn, stir-fried malt, stir-fried radish seeds, stir-fried chicken gizzard lining, and stir-fried white hyacinth bean into 80-120 mesh respectively;

[0013] S2. Boil raw yam, poria cocos, tangerine peel, agastache rugosa, polygonatum odoratum, dendrobium, jujube, dried plum, and dandelion root in water twice, combine the filtrates and concentrate to a thick paste;

[0014] S3. Mix the powder from step S1 with the paste from step S2, and dry to obtain a powder.

[0015] Preferably, the composition further contains excipients, including at least one of starch, dextrin, and flavoring agents.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] (1) By using stir-fried hawthorn, stir-fried malt, and stir-fried chicken gizzard to aid digestion and relieve stagnation; raw yam and poria to strengthen the spleen and replenish qi; dandelion root and polygonatum to clear heat and nourish yin; and stir-fried radish seed and dried plum to moisten the intestines and promote bowel movement, the dual effects of strengthening the spleen and aiding digestion and clearing heat and moistening the intestines are achieved. Experiments show that it can significantly increase gastric emptying rate and small intestinal propulsion rate, reduce the level of inflammatory factors, and increase intestinal absorption capacity, thereby fundamentally improving the problems of spleen and stomach weakness and intestinal dryness and heat.

[0018] (2) By using ingredients that are both food and medicine, the risk of dependence on chemical drugs is avoided. Long-term use is safe and supports the development of multiple dosage forms such as powder, granules, and capsules. Flavoring agents can be added to improve palatability. Attached Figure Description

[0019] Figure 1 This is a process flow diagram of the present invention. Detailed Implementation

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] Example 1:

[0022] Please see Figure 1 As shown, a medicinal and edible composition that promotes spleen and stomach absorption, clears heat, and moistens the intestines is composed of the following raw materials in parts by weight:

[0023] 12g of stir-fried hawthorn, 9g of stir-fried malt, 5g of raw yam, 5g of poria cocos, 5g of dried tangerine peel, 12g of stir-fried radish seeds, 6g of stir-fried chicken gizzard lining, 2g of agastache rugosa, 3g of polygonatum odoratum, 2g of dendrobium nobile, 3g of stir-fried white hyacinth bean, 2g of jujube, 1g of dried plum, and 2g of dandelion root;

[0024] The preparation method of the powder includes the following steps:

[0025] The roasted hawthorn, roasted malt, roasted radish seeds, roasted chicken gizzard lining, and roasted white hyacinth bean were pulverized separately and passed through a 100-mesh sieve to obtain fine powder A;

[0026] Add raw yam, poria cocos, dried tangerine peel, agastache rugosa, polygonatum odoratum, dendrobium nobile, jujube, dried plum, and dandelion root to 8 times the amount of water, decoct twice (1.5 hours the first time and 1 hour the second time), combine the filtrates, and concentrate under reduced pressure to a thick paste B with a relative density of 1.25 (measured at 60℃).

[0027] Fine powder A and thick paste B are mixed evenly, vacuum dried at 60°C, and then pulverized through an 80-mesh sieve to obtain a powder.

[0028] Example 2:

[0029] The difference from Example 1 is that after mixing fine powder A and thick paste B, dextrin (weight ratio 1:0.2) and flavoring agent steviol glycoside (0.5%) are added, granulated, dried at 60°C, granulated, and packaged into 5-gram granules per bag.

[0030] Example 3:

[0031] The difference from Example 1 is that it is composed of the following raw materials in parts by weight:

[0032] 15g of stir-fried hawthorn, 7g of stir-fried malt, 7g of raw yam, 3g of poria cocos, 7g of dried tangerine peel, 10g of stir-fried radish seeds, 8g of stir-fried chicken gizzard lining, 1g of agastache rugosa, 4g of Solomon's seal rhizome, 1g of dendrobium, 4g of stir-fried white hyacinth bean, 1g of jujube, 1.5g of dried plum, and 3g of dandelion root;

[0033] The preparation of the capsule composition includes the following steps:

[0034] All raw materials are pulverized through a 120-mesh sieve and mixed evenly.

[0035] Microcrystalline cellulose (10% of total weight) is added as a filler and filled into capsule shells, with each capsule containing 0.5 grams of powder.

[0036] Example 4: Pharmacodynamic Experiment (Animal Model)

[0037] SPF-grade mice were randomly divided into a blank group, a model group, a positive control group (digestive tablets), a low-dose group (0.5 g / kg) of Example 1, and a high-dose group (1.0 g / kg) of Example 1, with 10 mice in each group;

[0038] Except for the control group, the other groups used an irregular hunger and satiety diet combined with a high-fat diet to establish a model of spleen and stomach weakness.

[0039] The drug was administered by gavage for 14 consecutive days, while the control group and the model group were given normal saline.

[0040] The specific experimental data are as follows:

[0041] Table 1: Effects of the composition on digestive function in mice with spleen and stomach deficiency

[0042] Group Gastric emptying rate (%) Small intestinal propulsion rate (%) IL-6 (pg / mL) TNF-α (pg / mL) Blank group 82.3±4.1 75.6±3.8 15.2±2.1 18.5±1.9 Model group 48.7±5.2 42.3±4.5 63.8±6.7 58.4±5.3 Positive control group 65.4±4.9* 58.1±4.2* 38.9±4.5* 36.2±3.8* Example 1 Low-dose group 59.6±5.1* 53.7±4.7* 49.2±5.0* 45.8±4.1* Example 1 High-dose group 72.8±4.7** 64.9±4.3** 29.5±3.8** 31.7±3.2**

[0043] Table 2: Colonic histopathological score (0-3 points, the higher the score, the more severe the damage)

[0044] Group Inflammatory cell infiltration Mucosal integrity Gland destruction Blank group 0.2±0.1 0.1±0.1 0.0±0.0 Model group 2.8±0.3 2.5±0.4 2.6±0.3 Example 1 High-dose group 1.1±0.2** 0.8±0.2** 0.9±0.2**

[0045] In the table: data are expressed as mean ± standard deviation (n=10), *P<0.05 vs model group, **P<0.01 vs model group; IL-6 and TNF-α are serum inflammatory factors, and decreased values ​​indicate significant anti-inflammatory effects;

[0046] As shown above, the gastric emptying rate of the high-dose group in Example 1 was 32.7% higher than that of the model group (P<0.01), and the small intestinal propulsion rate was 28.4% higher (P<0.01). The serum IL-6 and TNF-α levels in the high-dose group in Example 1 were 41.2% and 38.6% lower than those in the model group (P<0.01), respectively. Inflammatory cell infiltration was observed in the colonic mucosa of the model group, while the mucosal structure of the group in Example 1 was intact and the inflammation was significantly reduced.

[0047] Example 5: Clinical Observation Trial

[0048] Sixty patients with spleen and stomach deficiency and constipation were randomly divided into an experimental group (granules as described in Example 2) and a control group (placebo), with 30 patients in each group; 5 grams twice daily for 4 consecutive weeks.

[0049] The specific experimental data are as follows:

[0050] Table 3: Changes in TCM syndrome scores (after 4 weeks of treatment)

[0051] Group Abdominal distension score (0-6 points) Appetite score (0-6 points) Bowel movement frequency (times / week) Overall effectiveness (%) Experimental group (front) 4.5±1.2 4.8±1.1 1.3±0.5 - Experimental group (back) 1.2±0.6** 1.5±0.7** 4.8±1.1** 93.3 Control group (before) 4.6±1.1 4.7±1.3 1.4±0.6 - Control group (after) 3.8±1.0 3.9±1.2 2.1±0.8 36.7

[0052] Table 4: Improvement in intestinal absorption function (D-xylose absorption rate)

[0053] Group Baseline D-xylose (mmol / L) Post-treatment D-xylose (mmol / L) Rate of change (%) experimental group 1.52±0.21 1.91±0.25** +25.8％ control group 1.50±0.20 1.55±0.22 +3.3％

[0054] The table includes TCM syndrome scores (abdominal distension, appetite, bowel frequency, etc.); serum D-xylose absorption rate (reflecting intestinal absorption function);

[0055] As shown above, the total effective rate of the experimental group was 93.3%, while that of the control group was 36.7% (P<0.01); the absorption rate of D-xylose in the experimental group increased by 25.8% compared with the baseline (P<0.01).

[0056] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A food-medicine composition that promotes spleen and stomach absorption, clears heat, and moistens the intestines, characterized in that, It consists of the following raw materials in parts by weight: 10-15g of stir-fried hawthorn, 7-11g of stir-fried malt, 3-7g of raw yam, 3-7g of poria cocos, 3-7g of dried tangerine peel, 10-15g of stir-fried radish seeds, 4-8g of stir-fried chicken gizzard lining, 1-3g of agastache rugosa, 2-4g of polygonatum odoratum, 1-3g of dendrobium, 2-4g of stir-fried white hyacinth bean, 1-3g of jujube, 0.5-1.5g of dried plum, and 1-3g of dandelion root.

2. The food-medicine composition for promoting spleen and stomach absorption, clearing heat and moistening the intestines according to claim 1, characterized in that, The weight parts of each raw material are as follows: 12g of stir-fried hawthorn, 9g of stir-fried malt, 5g of raw yam, 5g of poria cocos, 5g of dried tangerine peel, 12g of stir-fried radish seeds, 6g of stir-fried chicken gizzard lining, 2g of agastache rugosa, 3g of polygonatum odoratum, 2g of dendrobium, 3g of stir-fried white hyacinth bean, 2g of jujube, 1g of dried plum, and 2g of dandelion root.

3. The food-medicine composition for promoting spleen and stomach absorption, clearing heat and moistening the intestines according to claim 1, characterized in that: The composition is available in the form of powder, granules, capsules, tablets, or for oral administration.

4. The food-medicine composition for promoting spleen and stomach absorption, clearing heat and moistening the intestines according to claim 1, characterized in that, The method for preparing the powder includes the following steps: S1. Grind the stir-fried hawthorn, stir-fried malt, stir-fried radish seeds, stir-fried chicken gizzard lining, and stir-fried white hyacinth bean into 80-120 mesh respectively; S2. Boil raw yam, poria cocos, tangerine peel, agastache rugosa, polygonatum odoratum, dendrobium, jujube, dried plum, and dandelion root in water twice, combine the filtrates and concentrate to a thick paste; S3. Mix the powder from step S1 with the paste from step S2, and dry to obtain a powder.

5. The food-medicine composition for promoting spleen and stomach absorption, clearing heat and moistening the intestines according to claim 1, characterized in that: The composition also contains excipients, including at least one of starch, dextrin, and flavoring agents.

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