Scintillator excitation sensitizer system applied to malignant tumor 125 iodine particle therapy

By combining 3D modeling, radiation prediction, and localization calculation modules, scintillators with high atomic number elements and long afterglow materials are precisely implanted, solving the problem of scintillator material selection and localization in 125I particle therapy. This achieves improved ROS generation efficiency and reduced heavy metal toxicity risk, making it suitable for individualized treatment of various solid tumors.

CN120837849AInactive Publication Date: 2025-10-28TIANJIN FUXUN TECH DEV CO LTD
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Patent Information

Application Number
CN202511176755.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-21
Publication Date
2025-10-28
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

In existing technologies, the method of 125I particle therapy, which converts gamma rays into visible/ultraviolet light to activate photosensitizers and generate reactive oxygen species through scintillators, faces technical challenges in scintillator material selection and precise positioning. Low-energy gamma rays require elements with high atomic numbers to improve interception efficiency, the emission spectrum needs to be matched with the photosensitizer, and the low dose rate problem requires the accumulation of energy through long-afterglow materials. There is no mature solution for determining the optimal position of the scintillator by combining the three-dimensional structure of the tumor with the spatiotemporal distribution of radiation.

Method used

The system uses a 3D modeling module to acquire tumor tissue data, a radiation prediction module to calculate the spatiotemporal distribution of radiation dose rate, a positioning calculation module to determine the optimal placement position of the scintillator, and a guidance module for precise implantation. High atomic number element materials and long afterglow materials are used to improve energy conversion efficiency, and a multi-parameter optimization algorithm is combined to ensure the lowest possible ROS generation efficiency and heavy metal toxicity risk.

Benefits of technology

It achieves optimal localization of scintillators within tumors, improves ROS generation efficiency, reduces the risk of heavy metal toxicity, and enhances treatment efficacy and safety, making it suitable for individualized precision treatment of various solid tumors.

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Abstract

The invention relates to the technical field of malignant tumor treatment equipment, and discloses a scintillator excitation sensitizer system applied to malignant tumor 125 iodine particle treatment. Comprising a three-dimensional modeling module used for obtaining imaging data of tumor tissues and constructing a three-dimensional model; the radiation prediction module is used for calculating radiation dose rate space-time distribution around each radiator based on the 125 iodine particle cylinder radiator model, and forming an overall radiation dose rate space-time distribution prediction model through superposition; the positioning calculation module is used for determining the optimal placement position of the scintillator in the tumor tissue in combination with the three-dimensional model and the radiation dose rate space-time distribution prediction model; and the guiding module is used for generating a scintillator implantation path and guiding the puncture device to accurately implant the scintillator into the optimal implantation position. The optimal positioning of the scintillator in the tumor is realized, and the key problems of low-energy gamma ray energy conversion efficiency and safety are solved.
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