Antigen expression vector, monkey pox virus mRNA vaccine and composition

By designing an mRNA vaccine antigen expression vector containing monkeypox virus antigen proteins B6R, A29L, A35R, and M1R, and combining structural modification and liposome delivery, the problems of long development cycles and low production capacity of existing monkeypox mRNA vaccines have been solved, enabling rapid production and immune protection of highly efficient and safe multivalent monkeypox virus mRNA vaccines.

CN120843563APending Publication Date: 2025-10-28UNIV OF SCI & TECH OF CHINA +1
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Patent Information

Application Number
CN202410447974.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-04-15
Publication Date
2025-10-28

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Abstract

The invention discloses an antigen expression vector, a monkey pox virus mRNA vaccine and a composition, and relates to the technical field of monkey pox vaccines. The bivalent and tetravalent mRNA vaccines provided by the invention jointly express a combination of antigens from both IMV and EEV, and can provide sufficient protection against poxvirus attack. After the mRNA vaccine provided by the invention is injected into a mouse model, obvious body fluid and cellular immune response is shown, a body can be stimulated to quickly generate a specific IgG antibody within 2-4 weeks, and B lymphocytes can be stimulated to generate a high-level neutralizing antibody. In addition, the vaccine provided by the invention is simple to prepare, can simultaneously express a plurality of antigens, is strong in immunogenicity, and has good candidate vaccine potential.
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Patent Citations

  • Subunit vaccine of monkey pox virus as well as preparation method and application of subunit vaccine

    CN116603060A

  • MRNA (messenger Ribonucleic Acid) vaccine for fusion expression of protective antigen of monkey pox virus, composition for delivering mRNA vaccine as well as preparation method and application of mRNA vaccine

    CN116785423A