Nutrition enhancer for assisting in reducing hypertension, hyperglycemia and hyperlipidemia as well as preparation method and application of nutrition enhancer

Abstract

The invention belongs to the technical field of health-care products, and particularly relates to a nutrition enhancer for assisting in reducing hypertension, hyperglycemia and hyperlipidemia as well as a preparation method and application thereof. The nutrition enhancer for assisting in reducing the three highs comprises the following raw materials in parts by mass: 20-30 parts of puffed highland barley powder, 10-20 parts of Chinese yam powder, 5-15 parts of soybean protein, 10-20 parts of bitter gourd polypeptide, 1-10 parts of an exocarpium citri grandis extract and 10-20 parts of a cistanche deserticola extract. The nutrition enhancer disclosed by the invention has the effects of assisting in reducing blood sugar and blood fat, and also has a potential effect of reducing blood pressure.

Description

Technical Field

[0001] This invention belongs to the field of health product technology, with IPC classification number A23L33 / 00, and specifically relates to a nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, as well as its preparation method and application. Background Technology

[0002] Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. Poor long-term blood sugar control can lead to a variety of serious complications. It is worth noting that diabetic patients often do not have a single disease; some diabetic patients also have hypertension and / or hyperlipidemia. The coexistence of these three conditions is called "triple hypertension" or "metabolic syndrome," which greatly increases the risk of cardiovascular and cerebrovascular events and becomes a major cause of death and disability.

[0003] The invention patent with publication number CN111972658A and classification number A23L33 / 00 discloses a meal replacement food for lowering blood pressure, blood sugar, and cholesterol and its preparation method. The food is prepared from the following main raw materials in parts by weight: oats, Job's tears, kudzu root powder, black fungus, red yeast rice, skim milk powder, soy protein isolate, inulin, resistant dextrin, L-carnitine, taurine, nutritional additives, phospholipids, sucralose, and food flavoring.

[0004] The invention patent with publication number CN111329045A and classification number A23L33 / 00 discloses a buckwheat mixed grain powder for lowering blood pressure, blood sugar, and cholesterol. The components, by weight percentage, are 50%–80% buckwheat refined flour, 1%–10% konjac refined flour, 1%–10% Jerusalem artichoke powder, 10%–20% skim milk powder, and 10%–30% carrier. The buckwheat refined flour is a product obtained by germinating and pulverizing buckwheat. The carrier includes at least resistant dextrin.

[0005] Patent publication number CN110881655A and classification number A23L33 / 00 discloses a meal replacement food for lowering blood pressure, blood sugar, and cholesterol. This meal replacement food comprises the following ingredients in parts by weight: 20-32 parts kudzu root, 1-3 parts white kidney beans, 1-3 parts black beans, 1-3 parts pumpkin powder, 3-5 parts buckwheat, 0.5-3 parts Job's tears, 2-4 parts winged beans, 5-8 parts tartary buckwheat, 1-6 parts quinoa, 2.5-8 parts bitter melon, and 0.5-... The ingredients are: 5 parts brown rice, 1-3 parts wheat germ, 2-6 parts flaxseed powder, 20-35 parts golden wheat, 25-45 parts soybean peptides, 5-10 parts soy protein isolate, 1.5-6 parts water-soluble dietary fiber, and 8-15 parts. A method for preparing a meal replacement food for lowering blood pressure, blood sugar, and cholesterol includes the following steps: mixing the powdered ingredients from step A with the soup from step C in a 1:1 ratio, then allowing it to ferment naturally. After fermentation, the food is prepared.

[0006] Cistanche deserticola (Cistanche deserticola YC Ma), commonly known as "desert ginseng," is a perennial parasitic herb belonging to the genus Cistanche in the family Orobanchaceae. In 2021, the National Health Commission of China included Cistanche deserticola in its "List of Substances That Are Traditionally Both Food and Medicinal Herbs," allowing it to be taken directly, soaked in alcohol, cooked in porridge, soup, or brewed as tea. Cistanche deserticola commands a relatively high market price. Currently, it is mainly used for extraction as a component of traditional Chinese medicine or health products, but the residue after extraction is treated as waste, resulting in a serious waste of resources. Citrus reticulata peel (Huajuhong) was approved as a food and medicine homologous substance in 2024. It has expectorant, qi-regulating, stomach-strengthening, and digestive effects. Research on its use in products for lowering blood pressure, blood sugar, and cholesterol is relatively limited, and research in this field requires further development and refinement with relevant technologies. Summary of the Invention

[0007] The purpose of this invention is to provide a nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, as well as its preparation method and application.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] A nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 20-30 parts puffed highland barley flour, 10-20 parts Chinese yam powder, 5-15 parts soybean protein, 10-20 parts bitter melon polypeptide, 1-10 parts Citrus reticulata extract, and 10-20 parts Cistanche deserticola extract.

[0010] The puffed highland barley flour in the formula of this invention is rich in dietary fiber and β-glucan, which helps to delay sugar absorption and regulate insulin sensitivity; Chinese yam flour is rich in polysaccharides and amino acids, which can promote insulin secretion and improve glucose and lipid metabolism; soybean protein not only provides a high-quality source of plant protein, but also improves vascular elasticity through its isoflavones; bitter melon polypeptide has insulin-like activity, which can effectively lower blood sugar levels, and at the same time exerts a hypotensive effect by inhibiting angiotensin-converting enzyme (ACE); Citrus reticulata extract is rich in flavonoids, which have multiple functions such as antioxidation, anti-inflammation and blood lipid regulation; and Cistanche deserticola extract has a potential regulatory effect on blood pressure through mechanisms such as regulating the renin-angiotensin system and enhancing nitric oxide synthesis.

[0011] Preferably, the mass ratio of bitter melon polypeptide + Citrus reticulata extract to Cistanche deserticola extract is (18-23):(10-15).

[0012] By adding specific proportions of bitter melon polypeptide, Citrus reticulata extract, and Cistanche deserticola extract to the raw materials of this invention, the lipid-lowering effect of the nutritional fortifier can be significantly improved. Analysis shows that the three raw materials have a synergistic effect.

[0013] Preferably, the Cistanche deserticola extract is a residue generated during the preparation of Cistanche deserticola extract used in the preparation of health products or traditional Chinese medicines.

[0014] Preferably, the preparation method of Citrus reticulata extract includes the following steps:

[0015] (1) Wash, dry and pulverize the tangerine peel to obtain tangerine peel powder;

[0016] (2) Add sterile water and glucose to the tangerine peel powder to obtain fermentation raw material, add mixed bacteria, then anaerobic ferment, sterilize, and obtain fermentation product;

[0017] (3) Add ethanol to the fermentation product to make the volume fraction of ethanol reach 50%~60%, then heat and reflux to extract, separate solid and liquid, concentrate the supernatant under reduced pressure, and spray dry to obtain the Citrus reticulata extract.

[0018] Preferably, the dosage of the mixed bacteria is 10. 8 The fermentation feed consists of CFU / mL of mixed bacteria including Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:(1.2-1.4):(0.5-0.7).

[0019] Preferably, anaerobic fermentation at a constant temperature of 35-40℃ for 30-40 hours is performed.

[0020] The Citrus reticulata extract prepared by fermentation in this invention contains richer active components, which can have a better synergistic effect with bitter melon polypeptides and Cistanche deserticola extracts, thereby improving the effect of nutritional fortifiers on improving blood lipids, blood sugar, and blood pressure.

[0021] Preferably, the preparation method of Cistanche deserticola extract includes the following steps: drying and pulverizing Cistanche deserticola, soaking it in water, heating and refluxing it three times for 2 hours each time, filtering it through a filter membrane, collecting the extract and the extraction residue separately, drying the extraction residue, and obtaining Cistanche deserticola extract.

[0022] Preferably, the preparation method of the Chinese yam powder is as follows: peel fresh Chinese yam, cut it into small pieces, freeze-dry it, and pulverize it to less than 40 mesh.

[0023] The present invention provides a method for preparing the nutritional fortifier that assists in lowering blood pressure, blood sugar, and cholesterol, including the following steps: mixing all raw materials and pulverizing them with a pulverizer to obtain the nutritional fortifier that assists in lowering blood pressure, blood sugar, and cholesterol.

[0024] This invention provides the application of the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol in the preparation of foods that help lower these three factors.

[0025] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows:

[0026] 1. The nutritional fortifier of this invention is based on a scientific combination of various natural plant extracts and nutrients, exhibiting significant auxiliary effects in lowering blood sugar and blood lipids, while also demonstrating potential blood pressure-lowering effects. In addition to lowering blood sugar and blood lipids, the components of this invention act synergistically on the cardiovascular system through multiple mechanisms, further demonstrating an auxiliary regulatory function on blood pressure, making it particularly suitable for comprehensive nutritional intervention and health management for individuals with hypertension, hyperlipidemia, and hyperglycemia.

[0027] 2. By adding specific proportions of bitter melon polypeptide, Citrus reticulata extract, and Cistanche deserticola extract to the raw materials of this invention, the lipid-lowering effect of the nutritional fortifier can be significantly improved. Analysis suggests that the three raw materials have a synergistic effect.

[0028] 3. The Citrus reticulata extract prepared by fermentation in this invention contains richer active components, which can play a better synergistic role with bitter melon polypeptide and Cistanche deserticola extract, thereby improving the effect of nutritional fortifier on blood lipids, blood sugar and blood pressure. Detailed Implementation

[0029] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] The bacteria used in this invention are commercially available products.

[0031] *Lactobacillus plantarum* (CCTCC AB 2022355) and *Lactobacillus johnsonii* (CCTCC AB 2011139) were from the China Center for Type Culture Collection. *Lactobacillus rhamnosus* (CICC 22152), *Bifidobacterium adolescentis* (CICC 24573), and *Lactobacillus delbrueckii* (CICC 20707) were from the China Industrial Microbial Culture Collection Center. *Microbulbar pumilus* (MCCC 1K00052) was from the China Marine Microbial Culture Collection Center.

[0032] The Cistanche deserticola extract was obtained from Inner Mongolia Desert Cistanche Deserticola Co., Ltd. The preparation method is as follows: Cistanche deserticola was dried and pulverized to less than 80 mesh, soaked in 10 times its weight of water for 1 hour, and then heated and refluxed for extraction 3 times, 2 hours each time. The mixture was filtered through a 0.45 μm filter membrane, and the extract and the extraction residue were collected separately. The extraction residue was dried to obtain the Cistanche deserticola extract.

[0033] The preparation method of the Chinese yam powder is as follows: peel fresh Chinese yam, cut it into small pieces, freeze-dry it, and pulverize it to less than 40 mesh.

[0034] Bitter melon polypeptide, Gansu Yishengxiang Biotechnology Co., Ltd.

[0035] The puffed highland barley flour is produced using a twin-screw extruder. The operating parameters of the twin-screw extruder are: screw diameter 65mm, screw speed 200r / min, processing capacity 100kg / h, temperature control range 100°C, and motor power 22kW.

[0036] Example 1

[0037] This embodiment provides a nutritional fortifier to help lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 27 parts puffed highland barley flour, 14 parts Chinese yam powder, 10 parts soybean protein, 17 parts bitter melon polypeptide, 5 parts Citrus reticulata extract, and 13 parts Cistanche deserticola extract.

[0038] The preparation method of Citrus reticulata extract includes the following steps:

[0039] (1) Wash the tangerine peel, dry it, and pulverize it to less than 60 mesh to obtain tangerine peel powder;

[0040] (2) Sterilize the tangerine peel powder, add sterile water at 10 times the mass of the tangerine peel powder, and add glucose at 2% of the mass of the tangerine peel powder to obtain fermentation raw materials. Add mixed bacteria at a dosage of 10. 8 The fermentation feedstock consisted of Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:1.3:0.6. The mixture was then subjected to anaerobic fermentation at 37°C for 35 hours, followed by sterilization to obtain the fermentation product.

[0041] (3) Add ethanol to the fermentation product to make the volume fraction of ethanol reach 55%, then heat and reflux for 5 hours, separate the solid and liquid, concentrate the supernatant under reduced pressure, and spray dry to obtain the Citrus reticulata extract.

[0042] The preparation method of the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol includes the following steps: mixing all raw materials and pulverizing them to less than 100 mesh using a pulverizer to obtain the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol.

[0043] Example 2

[0044] This embodiment provides a nutritional fortifier to help lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 20 parts puffed highland barley flour, 20 parts Chinese yam powder, 5 parts soybean protein, 10 parts bitter melon polypeptide, 10 parts Citrus reticulata extract, and 15 parts Cistanche deserticola extract.

[0045] The preparation method of Citrus reticulata extract includes the following steps:

[0046] (1) Wash the tangerine peel, dry it, and pulverize it to less than 60 mesh to obtain tangerine peel powder;

[0047] (2) Sterilize the tangerine peel powder, add sterile water at 10 times the mass of the tangerine peel powder, and add glucose at 2% of the mass of the tangerine peel powder to obtain fermentation raw materials. Add mixed bacteria at a dosage of 10. 8 The fermentation feedstock consisted of Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:1.2:0.7. The mixture was then subjected to anaerobic fermentation at 37°C for 30 hours, followed by sterilization to obtain the fermentation product.

[0048] (3) Add ethanol to the fermentation product to make the volume fraction of ethanol reach 50%, then heat and reflux for 6 hours, separate the solid and liquid, concentrate the supernatant under reduced pressure, and spray dry to obtain the Citrus reticulata extract.

[0049] The preparation method of the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol includes the following steps: mixing all raw materials and pulverizing them to less than 100 mesh using a pulverizer to obtain the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol.

[0050] Example 3

[0051] This embodiment provides a nutritional fortifier to help lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 30 parts puffed highland barley flour, 10 parts Chinese yam powder, 15 parts soybean protein, 20 parts bitter melon polypeptide, 3 parts Citrus reticulata extract, and 10 parts Cistanche deserticola extract.

[0052] The preparation method of Citrus reticulata extract includes the following steps:

[0053] (1) Wash the tangerine peel, dry it, and pulverize it to less than 60 mesh to obtain tangerine peel powder;

[0054] (2) Sterilize the tangerine peel powder, add sterile water at 12 times the mass of the tangerine peel powder, and add glucose at 2% of the mass of the tangerine peel powder to obtain fermentation raw materials. Add mixed bacteria at a dosage of 10. 8 The fermentation feed consisted of CFU / mL of Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:1.4:0.5. The mixture was then anaerobic fermented at 37°C for 40 hours, sterilized, and the fermentation product was obtained.

[0055] (3) Add ethanol to the fermentation product to make the volume fraction of ethanol reach 60%, then heat and reflux for 4 hours, separate the solid and liquid, concentrate the supernatant under reduced pressure, and spray dry to obtain the Citrus reticulata extract.

[0056] The preparation method of the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol includes the following steps: mixing all raw materials and pulverizing them to less than 100 mesh using a pulverizer to obtain the nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol.

[0057] Comparative Example 1

[0058] This comparative example is the highland barley compound special dietary nutritional powder prepared in Example 1 of Chinese Patent CN 105077236 B.

[0059] Comparative Example 2

[0060] The difference between this comparative example and Example 1 is that the total number of bitter melon polypeptides, Citrus reticulata extract and Cistanche deserticola extract remains the same, but the ratio is changed.

[0061] A nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 27 parts puffed highland barley flour, 14 parts Chinese yam powder, 10 parts soybean protein, 13 parts bitter melon polypeptide, 2 parts Citrus reticulata extract, and 20 parts Cistanche deserticola extract.

[0062] Comparative Example 3

[0063] The difference between this comparative example and Example 1 is that the total number of bitter melon polypeptides, Citrus reticulata extract and Cistanche deserticola extract remains the same, but the ratio is changed.

[0064] A nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, comprising the following raw materials in parts by weight: 27 parts puffed highland barley flour, 14 parts Chinese yam powder, 10 parts soybean protein, 21 parts bitter melon polypeptide, 9 parts Citrus reticulata extract, and 5 parts Cistanche deserticola extract.

[0065] Comparative Example 4

[0066] The difference between this comparative example and Example 1 is that the Citrus reticulata extract is replaced with Pueraria lobata extract.

[0067] Comparative Example 5

[0068] The difference between this comparative example and Example 1 is that the mixed bacteria include short bacilli, Bifidobacterium adolescentis and Lactobacillus delbrueckii with a live bacteria ratio of 1:1.4:0.5.

[0069] Comparative Example 6

[0070] The difference between this comparative example and Example 1 is that the mixed bacteria include Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:1.1:0.4.

[0071] Comparative Example 7

[0072] The difference between this comparative example and Example 1 is that the mixed bacteria include Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:1.5:0.8.

[0073] Performance testing

[0074] The performance of the nutrient fortifiers prepared in Examples 1-3 and Comparative Examples 1-7 was tested.

[0075] (1) SPF grade Kunming male mice, weighing 21±2g, half male and half female, kept at a temperature of 25±2°C, relative humidity of 55±5%, with 12 hours of light per day and night, free access to food and water, and regular addition of feed and water every day.

[0076] After a single intraperitoneal injection of alloxan 160 mg / kg by bolus, mice with stable blood glucose levels at the model level (15-25 mmol / L) were selected. They were randomly divided into groups of 8.

[0077] Normal group: Healthy mice were administered 0.05g / 10g of nutritional fortifier by gavage.

[0078] Solvent control group: Healthy mice were administered physiological saline by gavage at a volume of 0.2 mL / 10 g BW.

[0079] Model group: Mice after modeling were administered physiological saline by gavage at a volume of 0.2 mL / 10 g BW.

[0080] Metformin group: Mice after modeling were administered 100 mg / kg metformin by gavage.

[0081] Experimental group: Mice after modeling were administered 0.05g / 10g of the nutritional fortifiers of Examples 1-3 and Comparative Examples 1-7 by gavage.

[0082] Fasting blood glucose levels were recorded before gavage and 45 days after gavage.

[0083] The results are shown in Table 1.

[0084] Table 1 Results of fasting blood glucose level test

[0085] Fasting blood glucose level before gavage (mmmol / L) Fasting blood glucose level after gavage (mmmol / L) normal group 7.48±1.36 7.63±1.47 Solvent control group 7.31±1.51 7.07±1.38 Model group 21.24±3.03 30.40±4.07 Metformin group 22.27±3.89 14.71±2.70 Example 1 20.36±3.14 17.28±2.41 Example 2 21.53±3.21 18.92±2.87 Example 3 21.02±3.35 18.36±2.53 Comparative Example 1 20.29±3.08 22.53±3.26 Comparative Example 2 21.13±3.45 26.45±3.54 Comparative Example 3 22.67±3.33 25.84±3.89 Comparative Example 4 22.82±3.04 25.18±3.35 Comparative Example 5 20.94±3.52 21.54±3.64 Comparative Example 6 21.76±3.06 20.42±3.71 Comparative Example 7 21.43±3.79 20.81±3.46

[0086] (2) SPF-grade male Kunming mice, weighing 21±2g, half male and half female, were housed at a temperature of 25±2°C and a relative humidity of 55±5%, with 12 hours of light per day and night. They had free access to food and water, and their food and water were added regularly each day. After 3 days of acclimatization, they were fed a high-fat diet (78.8% experimental basal diet, 10% lard, 1% commercially available cholesterol, 0.2% pig bile salts, and 10% egg yolk) for 35 days. Blood was collected from the tail vein, and a significant difference in serum TC was detected, which proved that the hyperlipidemic mouse model was successful. The mice were randomly divided into groups of 8. After successful modeling, the mice were administered drugs by gavage and continued to be fed a high-fat diet.

[0087] Normal group: Healthy mice were administered 500 mg / kg of BW nutritional fortifier by gavage.

[0088] Model group: Mice after modeling were administered physiological saline by gavage at a volume of 0.2 mL / 10 g BW.

[0089] Positive control group: Mice after modeling were administered ursolic acid aqueous solution at a concentration of 20 mg / mL by gavage, with a gavage dose of 10 mL / kg.

[0090] Experimental group: Mice after modeling were administered 500 mg / kg of the nutritional fortifiers from Examples 1-3 and Comparative Examples 1-7 by gavage.

[0091] After 5 weeks of oral administration of the drug to mice with hyperlipidemia, blood was collected from their eyeballs and they were euthanized by cervical dislocation. The total cholesterol level in their serum was then measured.

[0092] The results are shown in Table 2.

[0093] Table 2. Results of Total Cholesterol Level Test

[0094] TC (mmol / L) normal group 2.14±0.27 Model group 3.82±0.54 Positive control group 2.91±0.26 Example 1 3.05±0.25 Example 2 3.11±0.30 Example 3 3.16±0.26 Comparative Example 1 3.75±0.41 Comparative Example 2 3.51±0.55 Comparative Example 3 3.57±0.32 Comparative Example 4 3.44±0.23 Comparative Example 5 3.30±0.37 Comparative Example 6 3.21±0.44 Comparative Example 7 3.24±0.29

[0095] As shown in Table 1, the nutritional fortifiers of Examples 1-3 have the effect of lowering blood sugar and blood lipids. At the same time, the nutritional fortifiers of the present invention contain bitter melon polypeptides, flavonoids from Citrus reticulata peel, phenylethyl glycosides and polysaccharides from Cistanche deserticola, which can work synergistically to improve metabolic disorders and have the potential to regulate blood pressure.

[0096] The lipid-lowering effect of the existing technology product in Comparative Example 1 was not obvious.

[0097] The changes in the ratio of bitter melon polypeptide, Citrus reticulata extract and Cistanche deserticola extract in Comparative Examples 2 and 3 resulted in a decrease in the lipid-lowering and blood sugar-lowering effects, indicating that the synergistic effect of these three components under specific ratios can achieve the ideal lipid-lowering and blood sugar-lowering effects.

[0098] In Comparative Example 4, the Citrus reticulata extract was replaced with Pueraria lobata extract. Pueraria lobata is also a commonly used raw material for lowering blood sugar, but its effect was not ideal in the system of this invention. This shows that the raw materials of this invention are not simply additive components, but have a synergistic effect.

[0099] The effects of the modified microbial strains and formulations used in the preparation of tangerine peel extracts in Comparative Examples 5-7 decreased. Only when fermented under specific microbial strains can the active components produced achieve better synergistic effects with other components.

[0100] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol, characterized in that, The ingredients include the following parts by weight: 20-30 parts puffed highland barley flour, 10-20 parts Chinese yam flour, 5-15 parts soybean protein, 10-20 parts bitter melon polypeptide, 1-10 parts Citrus reticulata extract and 10-20 parts Cistanche deserticola extract.

2. The nutritional fortifier for assisting in lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that, The total mass of bitter melon polypeptide and Citrus reticulata extract: the mass ratio of Cistanche deserticola extract was (18-23): (10-15).

3. The nutritional fortifier for assisting in lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that, The Cistanche deserticola extract is a residue generated during the preparation of Cistanche deserticola extract used in the preparation of health products or traditional Chinese medicines.

4. The nutritional fortifier for assisting in lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that, The preparation method of Citrus reticulata extract includes the following steps: (1) Wash, dry and pulverize the tangerine peel to obtain tangerine peel powder; (2) Add sterile water and glucose to the tangerine peel powder to obtain fermentation raw material, add mixed bacteria, then anaerobic ferment, sterilize, and obtain fermentation product; (3) Add ethanol to the fermentation product to make the volume fraction of ethanol reach 50%~60%, then heat and reflux to extract, separate solid and liquid, concentrate the supernatant under reduced pressure, and spray dry to obtain the Citrus reticulata extract.

5. The nutritional fortifier for assisting in lowering blood pressure, blood sugar, and cholesterol according to claim 4, characterized in that, The mixed bacteria include Lactobacillus plantarum, Lactobacillus johnsonii, and Lactobacillus rhamnosus in a live bacteria ratio of 1:(1.2-1.4):(0.5-0.7).

6. The nutritional fortifier for assisting in lowering blood pressure, blood sugar, and cholesterol according to claim 5, characterized in that, The conditions for anaerobic fermentation are: constant temperature anaerobic fermentation at 35-40℃ for 30-40 hours.

7. The nutritional fortifier for lowering blood pressure, blood sugar, and cholesterol according to claim 3, characterized in that, The preparation method of Cistanche deserticola extract includes the following steps: drying and pulverizing Cistanche deserticola, soaking it in water, heating and reflux extraction, filtering through a filter membrane, collecting the extract and the extraction residue separately, drying the extraction residue to obtain Cistanche deserticola extract.

8. The nutritional fortifier for lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that, The preparation method of the Chinese yam powder is as follows: peel fresh Chinese yam, cut it into small pieces, freeze-dry it, and pulverize it to less than 40 mesh.

9. A method for preparing a nutritional fortifier for lowering blood pressure, blood sugar, and cholesterol as described in any one of claims 1-8, characterized in that, Includes the following steps: Mix all the ingredients, crush them, and you will get a nutritional fortifier that helps lower blood pressure, blood sugar, and cholesterol.

10. The application of the nutritional fortifier for lowering blood pressure, blood sugar, and cholesterol as described in any one of claims 1-8 in the preparation of foods for lowering blood pressure, blood sugar, and cholesterol.