A kind of food and medicine homologous hydrogen-rich beverage for assisting in reducing blood sugar and its preparation method

Abstract

A kind of food and medicine homologous hydrogen-rich beverage for assisting hypoglycemic and preparation method thereof belong to the field of health food processing technology, it overcomes the shortcomings of existing hypoglycemic beverage unreasonable compatibility, weak efficacy, active ingredient loss, insufficient safety, the present application is prepared from the following raw materials, by weight parts, mulberry leaf 12-18 parts, bitter gourd 15-20 parts, 8-12 parts of rhizoma polygonati, 6-10 parts of polygonatum, 10-16 parts of radix puerariae, high-concentration hydrogen-rich water is supplemented to 900-1100 parts, erythritol 3-5 parts.

Description

Technical Field

[0001] This invention belongs to the field of health food processing technology, and in particular to a hydrogen-rich beverage that is both food and medicine and has the same origin, which helps to lower blood sugar, and its preparation method. Background Technology

[0002] Hyperglycemia and type 2 diabetes have become prevalent chronic metabolic diseases worldwide. Long-term high blood sugar can easily lead to complications affecting multiple systems, including the cardiovascular, renal, and nervous systems, seriously endangering human health. Although commonly used hypoglycemic drugs can quickly control blood sugar, long-term use has drawbacks such as gastrointestinal reactions, the risk of hypoglycemia, and metabolic burden on the liver and kidneys, making them unsuitable for daily long-term management.

[0003] Currently, existing herbal drinks for lowering blood sugar often suffer from the following drawbacks: First, they use only one or two ingredients, resulting in poor synergy and limited, slow-acting blood sugar-lowering effects. Second, the carrier is ordinary purified water, lacking active synergistic ingredients, which cannot improve the oxidative stress damage caused by high blood sugar. Third, the preparation process often involves high-temperature boiling, which destroys heat-sensitive active ingredients such as flavonoids, saponins, and polysaccharides in the ingredients, reducing the product's efficacy. Fourth, the formulas often contain added sucrose and fructose syrup, which can actually raise blood sugar levels, limiting the target population.

[0004] According to patent novelty searches and comparisons with existing technologies, there are no publicly available technologies for preparing a blood sugar-lowering beverage by combining mulberry leaves, bitter melon, polygonatum, Solomon's seal, kudzu root, and high-concentration hydrogen-rich water with low-temperature extraction and instantaneous high-temperature sterilization processes. Summary of the Invention

[0005] The purpose of this invention is to provide a hydrogen-rich beverage made from food and medicinal ingredients and using hydrogen-rich water as a carrier to assist in lowering blood sugar, and its preparation method. It overcomes the shortcomings of existing hypoglycemic beverages, such as unreasonable formulation, weak efficacy, loss of active ingredients, and insufficient safety. This invention achieves its purpose by using the following raw materials, by weight: 12-18 parts mulberry leaves, 15-20 parts bitter melon, 8-12 parts polygonatum, 6-10 parts Solomon's seal, 10-16 parts kudzu root, high-concentration hydrogen-rich water to make up to 900-1100 parts, and 3-5 parts erythritol.

[0006] The preparation steps of this invention are as follows: Step 1: Raw material pretreatment: Weigh mulberry leaves, bitter melon, polygonatum, unicornu, and kudzu root according to the formula weight parts, manually remove mold and impurities, rinse 3 times with running water, cut into small sections / slices, place in a low-temperature vacuum drying oven at 40-50℃, dry until the moisture content is ≤8%, pulverize and pass through a 40-60 mesh pharmacopoeia sieve to obtain a fine powder of mixed raw materials; Step 2: Low-temperature extraction: Add 8-10 times the amount of high-concentration hydrogen-rich water to the fine powder of mixed raw materials, put it into a constant temperature extraction tank, control the temperature at 55-65℃, stir and extract for 60-90 minutes at a stirring speed of 30-50 r / min, after extraction, filter through a 200-mesh filter cloth to remove the residue, and obtain the herbal extract stock solution; Step 3: Preparation and homogenization: Add erythritol to the extract stock solution, stir at low speed until completely dissolved, add hydrogen-rich water to 900-1100 parts, and homogenize under high pressure at 25-31 MPa for 2 minutes. Second, ensure the beverage is uniform and stable, without sediment or layering; Step 4: Instant sterilization: The homogenized preparation solution is transported through pipelines to an ultra-high temperature instant sterilizer, with the temperature controlled at 110-120℃ and the sterilization time at 3-5 seconds. After sterilization, it is immediately cooled to 25-30℃ through a plate heat exchanger. Step 5: Aseptic filling and packaging. The cooled beverage is sent to the aseptic filling workshop, where it is filled and sealed using food-grade aseptic packaging materials. After passing quality inspection, the finished beverage is obtained.

[0007] Optimal formula: 15 parts mulberry leaves, 18 parts bitter melon, 10 parts polygonatum, 8 parts Solomon's seal, 13 parts kudzu root, high-concentration hydrogen-rich water to make up to 1000 parts, and 4 parts erythritol.

[0008] Among them, the dissolved hydrogen content of the high-concentration hydrogen-rich water is ≥1.6ppm and the oxidation-reduction potential (ORP) is ≤-450mV; all raw materials are within the scope of the "National List of Food and Drug Homologous Items", comply with the national food safety standards GB 2760 and GB 7101, and do not contain preservatives, pigments, flavorings, sucrose, or ingredients prohibited for medicinal use.

[0009] The beneficial effects of this invention are: it provides a scientifically formulated, synergistic, highly active, sugar-free, safe, and industrially producible auxiliary hypoglycemic food-grade hydrogen-rich beverage, which is especially suitable for daily dietary therapy and health care for people with impaired glucose tolerance, impaired fasting glucose, and high risk of type 2 diabetes.

[0010] The specific effects are as follows: 1. Innovative formulation for significant blood sugar reduction: This invention adopts a triple formulation approach of "core blood sugar reduction + Yin-nourishing and pancreatic protection + microcirculation regulation". With mulberry leaves (containing DNJ) and bitter melon (containing bitter melon polypeptides and saponins) as the core, it directly inhibits α-glucosidase, delays sugar absorption, and mimics insulin activity. Combined with Polygonatum sibiricum and Polygonatum odoratum to nourish Yin and moisten dryness, repair pancreatic islet cells, and relieve thirst symptoms. Pueraria lobata is added to improve insulin resistance and regulate the body's microcirculation. High-concentration hydrogen-rich water removes advanced glycation end products, has antioxidant properties, and reduces oxidative damage to the pancreatic islets. The synergistic effect of multiple components and multiple targets makes the blood sugar reduction effect far superior to that of a single formula. Experiments have verified that the postprandial blood glucose reduction is increased by more than 40%.

[0011] 2. High safety and wide range of applicable groups: All ingredients are food and medicine homologous, non-toxic and non-addictive. Erythritol is used as a sugar-free sugar substitute, which does not participate in blood sugar metabolism and does not produce calories. Diabetic patients, people with impaired glucose tolerance, and middle-aged and elderly people can drink it daily for a long time without any side effects.

[0012] 3. Advanced technology, complete preservation of active ingredients: Low-temperature extraction is used instead of traditional high-temperature decoction, combined with instantaneous high-temperature sterilization at 110-120℃, which maximizes the preservation of heat-sensitive hypoglycemic active ingredients in the ingredients and avoids loss of efficacy. At the same time, it ensures that the product meets the microbial standards and complies with food safety production standards.

[0013] 4. Suitable for industrial production: The preparation process is simple, the equipment is universal, and the operation is convenient. It can realize large-scale mass production, and the production cost is controllable. It has strong practicality and market transformation value.

[0014] The research team of this project observed statistical data on the effects of hydrogen-rich water combined with herbal medicine on 120 people with hyperglycemia: (I) Basic Instructions 1. Compound formula: 15 parts mulberry leaves, 18 parts bitter melon, 10 parts polygonatum, 8 parts Solomon's seal, 13 parts kudzu root, 1000 parts high-concentration hydrogen-rich water, and 4 parts erythritol; 2. Group setup: A. Blank group (ordinary drinking water), B. Single hydrogen group (pure hydrogen-rich water), C. Herbal group (herbal medicine + ordinary drinking water), D. Compound test group (hydrogen-rich + herbal medicine); 3. Sample size: 30 cases per group, totaling 120 cases; 4. Intervention period: 28 consecutive days of intervention, with a fixed daily dose. 5. Test indicators: fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPBG), and glycated hemoglobin (HbA1c); 6. Testing time: before intervention, 7 days, 14 days, 28 days after intervention, and 7 days after intervention (follow-up); (II) Basic data statistics of clinical observation of four groups of subjects (n=30): Table 1

[0015] (III) Criteria for Evaluating Therapeutic Effect Significant effect: fasting blood glucose <7.0 mmol / L, or 2-hour postprandial blood glucose <8.0 mmol / L, and HbA1c decrease ≥1.0%; Effective: Fasting blood glucose decreased by ≥1.0 mmol / L, 2-hour postprandial blood glucose decreased by ≥2.0 mmol / L, and HbA1c decreased by 0.5%-0.9%; Ineffective: The above standards are not met, and blood glucose levels show no improvement or even increase; Overall effectiveness rate: (Significantly effective + Effective) / Number of cases in this group × 100%; (iv) Fill in the remarks Standardized blood glucose meter testing, fasting for 8-12 hours, and accurate post-meal timing; During the intervention, discontinue the use of other blood sugar-lowering health products and medications, and maintain a consistent diet and exercise routine. Record adverse reactions in detail, including symptoms, time of occurrence, and treatment. (V) Statistical Summary of Clinical Observation on the Lowering of Blood Sugar by Hydrogen-Rich Water Combined with Food-Based Herbs

[0016] Objective: To explore the hypoglycemic effects of hydrogen-rich water, medicinal herbs (both alone and in combination), and to screen the optimal hypoglycemic dietary intervention program. Methods: 120 subjects were randomly divided into four groups: A) blank control group, B) hydrogen-rich water group, C) medicinal herbs group, and D) combined treatment group, with 30 subjects in each group. The intervention period was 28 days. Fasting blood glucose, 2-hour postprandial blood glucose, and glycated hemoglobin (HbA1c) levels were measured before and after intervention in each group. Clinical efficacy was statistically analyzed using one-way ANOVA and χ² test. Results: After 28 days of intervention, compared with the blank group (A), the fasting blood glucose, 2-hour postprandial blood glucose, and HbA1c levels of subjects in groups B, C, and D were significantly reduced, with highly significant differences in the decrease values ​​(P < 0.01). Among them, the D compound treatment group showed the best hypoglycemic effect, with decreases in fasting blood glucose, 2-hour postprandial blood glucose, and HbA1c of 2.3 mmol / L, 5.3 mmol / L, and 1.7%, respectively, which were significantly higher than those in the single hydrogen group (B) and the herbal group (C) (P < 0.05 or P < 0.01), and the total clinical effective rate reached 100%. Conclusion: The combination of hydrogen-rich water and medicinal and edible herbs has a synergistic hypoglycemic effect, with a significantly better hypoglycemic effect than single intervention regimens. It can effectively improve the blood glucose and glycated hemoglobin levels of subjects and has good value for the development of functional hypoglycemic beverages and clinical dietary therapy applications. Detailed Implementation

[0017] The present invention will be further described in detail below with reference to specific embodiments. The following embodiments are only used to illustrate the present invention and are not intended to limit the scope of protection of the present invention.

[0018] Example 1: This invention is prepared from the following raw materials, by weight: 12-18 parts mulberry leaves, 15-20 parts bitter melon, 8-12 parts polygonatum, 6-10 parts Solomon's seal, 10-16 parts kudzu root, high-concentration hydrogen-rich water to make up to 1000 parts, and 3-5 parts erythritol. The preparation steps are as follows: Step 1: Raw material pretreatment: Weigh each ingredient, remove impurities and wash, dry at 40-50℃, pulverize through a 40-60 mesh sieve to obtain a mixed fine powder; Step 2: Low-temperature extraction: Add 8-10 times the amount of hydrogen-rich water, extract at 55-65℃ with constant stirring for 60-90 min, stirring speed 30-50 r / min, filter through a 200 mesh sieve to obtain the extract stock solution; Step 3: Homogenization: Dissolve erythritol, add hydrogen-rich water to make up to 900-1100 parts, homogenize under high pressure at 25-31 MPa for 2 minutes. The fourth step is instant sterilization: sterilize at 110-120℃ for 3-5 seconds, and quickly cool to room temperature; the fifth step is aseptic filling to obtain the finished blood sugar-lowering beverage.

[0019] Example 2: This invention is prepared from the following raw materials, by weight: 15 parts mulberry leaves, 18 parts bitter melon, 10 parts polygonatum, 8 parts Solomon's seal, 13 parts kudzu root, high-concentration hydrogen-rich water to make up to 1000 parts, and 4 parts erythritol. The preparation steps are as follows: Step 1: Raw material pretreatment: Weigh each ingredient, remove impurities and wash, dry at 45℃, pulverize and pass through a 50-mesh sieve to obtain a mixed fine powder; Step 2: Low-temperature extraction: Add 9 times the amount of hydrogen-rich water, stir and extract at 60℃ for 75 min, stirring speed 40 r / min, filter through a 200-mesh sieve to obtain the extract stock solution; Step 3: Mixing and homogenization: Add erythritol to dissolve, add hydrogen-rich water to make up to 1000 parts, homogenize twice under high pressure at 28MPa; Step 4: Instant sterilization: Sterilize at 110℃ for 4s, and quickly cool to room temperature; Step 5: Aseptic filling to obtain the finished blood sugar lowering beverage.

[0020] Example 3: The moisture content of the raw material after drying is ≤8%.

[0021] Example 4: The hydrogen-rich water has a dissolved hydrogen content ≥1.6ppm and an oxidation-reduction potential (ORP) ≤-450mV.

Claims

1. A hydrogen-rich beverage derived from both food and medicine, which helps lower blood sugar, characterized by: It is prepared from the following raw materials, by weight: 12-18 parts mulberry leaves, 15-20 parts bitter melon, 8-12 parts polygonatum, 6-10 parts Solomon's seal, 10-16 parts kudzu root, high-concentration hydrogen-rich water to make up to 1000 parts, and 3-5 parts erythritol. The preparation steps are as follows: Step 1: Raw material pretreatment: Weigh each ingredient, remove impurities and clean, dry at low temperature of 40-50℃, pulverize and pass through a 40-60 mesh sieve to obtain a mixed fine powder; Step 2: Low temperature extraction: Add 8-10 times the amount of hydrogen-rich water, stir and extract at a constant temperature of 55-65℃ for 60-90 min, stirring speed of 30-50 r / min, and filter through a 200 mesh sieve to obtain the extract stock solution; Step 3: Mixing and homogenization: Add erythritol to dissolve, add hydrogen-rich water to make up to 900-1100 parts, and homogenize twice under high pressure of 25-31 MPa; Step 4: Instant sterilization: Sterilize at 110-120℃ for 3-5 seconds, and quickly cool to room temperature; Step 5: Aseptic filling to obtain the finished blood sugar lowering beverage.

2. The hydrogen-rich beverage derived from food and medicine for assisting in lowering blood sugar as described in claim 1, characterized in that: It is prepared from the following raw materials, by weight: 15 parts mulberry leaves, 18 parts bitter melon, 10 parts polygonatum, 8 parts Solomon's seal, 13 parts kudzu root, high-concentration hydrogen-rich water to make up to 1000 parts, and 4 parts erythritol. The preparation steps are as follows: Step 1: Raw material pretreatment: Weigh each ingredient, remove impurities and clean, dry at 45℃, pulverize and pass through a 50-mesh sieve to obtain a mixed fine powder; Step 2: Low-temperature extraction: Add 9 times the amount of hydrogen-rich water, stir and extract at 60℃ for 75 min, stirring speed 40 r / min, and filter through a 200-mesh sieve to obtain the extract stock solution; Step 3: Mixing and homogenization: Add erythritol to dissolve, add hydrogen-rich water to make up to 1000 parts, and homogenize twice under high pressure at 28MPa; Step 4: Instant sterilization: Sterilize at 110℃ for 4s, and quickly cool to room temperature; Step 5: Aseptic filling to obtain the finished blood sugar-lowering beverage.

3. The hydrogen-rich beverage derived from food and medicine for assisting in lowering blood sugar as described in claim 1, characterized in that: The moisture content of the raw materials after the first drying step is ≤8%.

4. A hydrogen-rich beverage derived from food and medicine for assisting in lowering blood sugar, as described in claim 1, characterized in that: The hydrogen-rich water has a dissolved hydrogen content ≥1.6ppm and an oxidation-reduction potential (ORP) ≤-450mV.

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