Composition with effect of assisting in reducing blood fat as well as preparation method and application of composition

Abstract

The invention discloses a composition with an auxiliary blood fat reducing effect as well as a preparation method and application thereof, and relates to the technical field of medicines. In the composition disclosed by the invention, the hawthorn, the lotus leaf, the mulberry leaf and the algae oil are mutually matched for use and have a synergistic effect, so that the effects of remarkably reducing the body weight, reducing the content of low-density lipoprotein, the content of Apo-B and the content of GLU in blood and improving indexes of high-density lipoprotein and Apo-A1 are achieved. The composition is applied to preparation of the blood fat reducing medicine and / or health food, and the blood fat reducing effect is stable.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to a composition with an auxiliary lipid-lowering effect, its preparation method, and its application. Background Technology

[0002] Hyperlipidemia is a condition in which the levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in the blood are elevated, while the level of high-density lipoprotein cholesterol (HDL-C) is decreased. It not only causes atherosclerosis and increases the risk of cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke, but is also closely related to the occurrence and development of diseases such as fatty liver and pancreatitis. Currently, the main medications used clinically to treat hyperlipidemia include statins, fibrates, niacin, and cholesterol absorption inhibitors. Statins primarily work by inhibiting HMG-CoA reductase, reducing cholesterol synthesis and thus lowering LDL-C levels in the blood. However, long-term use of statins may cause adverse reactions such as muscle pain, liver damage, and elevated blood sugar. Fibrates are mainly used to lower triglyceride levels, but their use alone or in combination with statins carries the risk of increasing myopathy and rhabdomyolysis. While niacin effectively raises HDL-C levels, it can cause discomfort such as skin flushing and itching, leading to poor patient compliance. Cholesterol absorption inhibitors have a single mechanism of action and often require combination with statins to achieve the desired lipid-lowering effect, which not only increases treatment costs but may also introduce more drug interaction risks. While some natural plant extracts and health products claim to lower blood lipids, their effectiveness and safety lack sufficient clinical evidence due to their complex composition, unclear mechanisms of action, and difficulty in controlling quality standards. Traditional Chinese medicinal herbs such as hawthorn, lotus leaf, and alisma, as well as classic compound preparations like Xuezhikang capsules, demonstrate unique advantages in regulating lipid metabolism through the synergistic effects of multiple components and targets.

[0003] Chinese invention patent CN111184783A discloses a compound mulberry leaf lipid-lowering tea bag with lipid-lowering effect and its preparation method, which is composed of six ingredients: mulberry leaf, hawthorn, lotus leaf, sophora japonica flower buds, monk fruit, and radish seed. The preparation method involves extracting the prescription medicinal materials with water, concentrating the extract, precipitating the concentrate with ethanol, concentrating, drying, and pulverizing the precipitate to obtain a concentrated medicinal extract powder, and then adding black tea or other medicinal (or edible) materials.

[0004] Chinese invention patent CN113907231A discloses a method for preparing a mulberry leaf bio-beverage, comprising the following steps: weighing fresh mulberry leaves, angelica dahurica, hawthorn, lotus leaves, coix seed, poria cocos, dandelion, appropriate amount of water, and seasoning ingredients; primary fermentation: fermenting fresh mulberry leaves with a compound bacterial solution containing Aspergillus niger, Trichoderma, brewer's yeast, and water to obtain a primary fermentation liquid; promoting fermentation: adding angelica dahurica to the primary fermentation liquid for continued fermentation, inactivating and filtering to obtain a promoted fermentation liquid; traditional Chinese medicine fermentation: mixing hawthorn, lotus leaves, coix seed, poria cocos, and dandelion, adding Lactobacillus plantarum, brewer's yeast, and water for fermentation, inactivating and filtering to obtain a traditional Chinese medicine fermentation liquid; mixing the promoted fermentation liquid, traditional Chinese medicine fermentation liquid, water, and seasoning ingredients evenly, and boiling to obtain the beverage.

[0005] In their article "Research and Efficacy Study of Hawthorn, Lotus Leaf and Buckwheat Plant Beverage" (Liu Li, Wu Lei, Wang Chuning, et al. Research and Efficacy Study of Hawthorn, Lotus Leaf and Buckwheat Plant Beverage [J]. Chinese Materia Medica and Clinical Practice, 2023, 14(01):36-41.), Liu Li et al. developed a "medicinal and edible" plant beverage with auxiliary hypoglycemic and hypolipidemic effects. The beverage was made from a combination of bitter buckwheat and hawthorn, lotus leaf, mulberry leaf, mulberry, kudzu root, and buckwheat, all "medicinal and edible" plants. The beverage was decocted three times with 12 times the amount of water each time, for 1 hour, concentrated under normal pressure, and centrifuged for 20 minutes. The total cholesterol and triglycerides in egg yolk-induced hyperlipidemia mice drinking the beverage were significantly lower than those in the egg yolk-induced hyperlipidemia model control group; blood glucose levels in egg yolk-induced hyperlipidemia mice were significantly lower than those in the blank control group; blood glucose levels in the alloxan-induced diabetes model control group were significantly higher than before administration; and the difference in blood glucose levels before and after drinking the beverage was significantly lower than that in the model control group. This indicates that the hawthorn, lotus leaf, and buckwheat beverage has the effects of lowering blood lipids and blood sugar.

[0006] However, current formulations of traditional Chinese medicine for lowering blood lipids are complex, often employing at least six components, resulting in unclear efficacy and a lack of synergistic regulatory effects. Furthermore, the lipid-lowering effects of some compositions are unstable, exhibiting significant individual variations and marked differences in efficacy among different patients. Therefore, there is a need to develop a composition that is simple in composition, safe and effective, with a clear mechanism of action, few adverse reactions, and significant lipid-lowering efficacy. Summary of the Invention This invention provides a composition with auxiliary lipid-lowering effects, its preparation method, and its application. The composition has simple components and stable lipid-lowering effects. Hawthorn, lotus leaf, mulberry leaf, and algal oil, through scientific formulation and a simple preparation process, significantly reduce weight, lower the levels of low-density lipoprotein (LDL-C), Apo-B, and GLU in the blood, and increase high-density lipoprotein (HDL-C) and Apo-A1 levels.

[0007] To achieve the above-mentioned objectives, the technical solution of the present invention is as follows: First, the present invention provides a composition with an auxiliary effect in lowering blood lipids, which consists of the following components: hawthorn, lotus leaf, mulberry leaf and algal oil.

[0008] Preferably, the composition comprises, by weight, the following components: 7-12 parts hawthorn, 7-12 parts lotus leaf, 4-9 parts mulberry leaf and 0.5-2 parts algal oil.

[0009] More preferably, the composition comprises, by weight, the following components: 9 parts hawthorn, 9 parts lotus leaf, 6 parts mulberry leaf and 1 part algal oil.

[0010] Then, the present invention provides a method for preparing the above composition, comprising the steps of: decocting hawthorn, lotus leaf and mulberry leaf with water to extract, concentrating the extract, and then mixing it with algal oil to obtain the composition.

[0011] Preferably, in the preparation method, the amount of water added during the extraction process is 5-15 times the mass of hawthorn, lotus leaf, and mulberry leaf.

[0012] More preferably, in the preparation method, the amount of water added during the extraction process is 10 times the mass of hawthorn, lotus leaf, and mulberry leaf.

[0013] Preferably, in the preparation method, the decoction is performed 1-3 times, each time for 0.5-2 hours.

[0014] More preferably, in the preparation method, the decoction is performed twice, each time for 1 hour.

[0015] Preferably, the concentration of the extract is divided into two steps: first, the extract is concentrated to 70%-90% of its original volume, then centrifuged, and the supernatant is taken and further concentrated to 20%-40% of the original extract volume.

[0016] More preferably, the concentration of the extract is divided into two steps: first, the extract is concentrated to 80% of its original volume, then centrifuged, and the supernatant is taken and further concentrated to 30% of the original extract volume.

[0017] Preferably, in the preparation method, the mixture needs to be dried before being mixed with algal oil.

[0018] The present invention then provides the use of the above composition in the preparation of lipid-lowering drugs and / or health foods.

[0019] Furthermore, the present invention provides a lipid-lowering drug comprising the above-mentioned composition.

[0020] Preferably, the lipid-lowering drug further includes the component maltodextrin.

[0021] More preferably, the mass ratio of the composition to maltodextrin is 18.5-35:20-40.

[0022] More preferably, the mass ratio of the composition to maltodextrin is 1:1.

[0023] Furthermore, the present invention provides a lipid-lowering health food, comprising the above-mentioned composition.

[0024] Finally, the present invention provides a method for preparing the above-mentioned lipid-lowering drug or lipid-lowering health food, comprising the steps of: decocting hawthorn, lotus leaf and mulberry leaf in water to extract the lipids, concentrating the extract, mixing it with maltodextrin, and then mixing it with algal oil to obtain the lipid-lowering drug or lipid-lowering health food.

[0025] Preferably, in the preparation method, the amount of water added during the extraction process is 5-15 times the mass of hawthorn, lotus leaf, and mulberry leaf.

[0026] More preferably, in the preparation method, the amount of water added during the extraction process is 10 times the mass of hawthorn, lotus leaf, and mulberry leaf.

[0027] Preferably, in the preparation method, the decoction is performed 1-3 times, each time for 0.5-2 hours.

[0028] More preferably, in the preparation method, the decoction is performed twice, each time for 1 hour.

[0029] Preferably, the concentration of the extract is divided into two steps: first, the extract is concentrated to 70%-90% of its original volume, then centrifuged, and the supernatant is taken and further concentrated to 20%-40% of the original extract volume.

[0030] More preferably, the concentration of the extract is divided into two steps: first, the extract is concentrated to 80% of its original volume, then centrifuged, and the supernatant is taken and further concentrated to 30% of the original extract volume.

[0031] Preferably, in the preparation method, after mixing with maltodextrin, a drying process is required.

[0032] In this invention, hawthorn has the effect of promoting digestion and removing blood stasis, lotus leaf has the effect of clearing the mind and removing turbidity, mulberry leaf has the effect of calming the liver and clearing heat, and algal oil has the effect of moistening the intestines and clearing the meridians. The four ingredients work synergistically: mulberry leaf in the upper burner clears lung heat, hawthorn and lotus leaf in the middle burner strengthen the spleen and stomach, and algal oil in the lower burner nourishes kidney water and moistens the intestines and promotes bowel movements. The combination of the four ingredients, which are cold and warm in nature, is suitable for long-term use.

[0033] In this invention, lotus leaf, mulberry leaf and algal oil together activate the PPAR-α pathway and accelerate fatty acid β-oxidation; the bile secretion-promoting effects of algal oil and hawthorn synergistically accelerate cholesterol metabolism.

[0034] In this invention, hawthorn, mulberry leaves, lotus leaves, and algal oil are used in combination. Hawthorn is the principal ingredient, which is sour, sweet, and slightly warm, and enters the spleen, stomach, and liver meridians. It has the effects of promoting digestion, eliminating food stagnation, and activating blood circulation. The flavonoids and organic acids contained in hawthorn can significantly reduce serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), and inhibit the activity of key cholesterol synthesis enzymes (such as HMG-CoA reductase). Therefore, it is the principal ingredient in the formula and plays a leading role in lowering lipids. Mulberry leaves are the assistant ingredient, which is bitter, sweet, and cold, and enters the lung and liver meridians. They function to disperse wind-heat and clear the liver and improve eyesight. They are rich in polysaccharides, flavonoids, and alkaloids (such as 1-deoxynojirimycin, DNJ), which can delay fat absorption by inhibiting intestinal α-glucosidase, while regulating liver lipid metabolism and reducing triglyceride (TG) accumulation, thus assisting hawthorn in synergistically lowering lipids. Lotus leaf, used as an adjuvant, is bitter, astringent, and neutral in nature, entering the liver, spleen, and stomach meridians. It can clear heat and dampness, and promote the upward movement of clear yang. Lotus leaf alkaloids and proanthocyanidins can activate the AMPK signaling pathway, promote fatty acid oxidation, reduce lipid synthesis, and have a mild diuretic effect to help excrete turbid lipids. Its nature is mild, harmonizing the warmth of hawthorn and the coldness of mulberry leaf, thus serving as an adjuvant. The combination of these three herbs synergistically enhances their effects through multiple targets (intestinal absorption, liver synthesis, and peripheral metabolism), but lacks a combination that nourishes kidney yin and moistens the intestines to relieve constipation. From the perspective of basic TCM theory, algal oil is moist and smooth, entering the kidney meridian: algae grow in water and acquire yin-cold energy. Its oil is soft and moist, able to nourish yin and replenish essence, and tonify kidney yin. It is suitable for symptoms such as dizziness, tinnitus, soreness of the waist and knees, and five-center heat caused by kidney yin deficiency. At the same time, algal oil has a good lipid-lowering effect, so it is used in combination with hawthorn, mulberry leaf, and lotus leaf to enhance its lipid-lowering effect.

[0035] The beneficial effects of this invention are as follows: The composition of the present invention consists of hawthorn, lotus leaf, mulberry leaf and algal oil. The components work together to achieve multi-target regulation, resulting in the technical effect of synergistically lowering blood lipids and improving metabolism. Detailed Implementation

[0036] To make the technical means, creative features, and achieved objectives and effects of this invention easier to understand, the invention is further illustrated below with specific embodiments. However, the following embodiments are merely preferred embodiments of this invention and not all embodiments. Other embodiments obtained by those skilled in the art based on the embodiments described herein without creative effort are all within the protection scope of this invention. Unless otherwise specified, the operating methods and equipment used in the following embodiments are conventional operating methods, and the materials and equipment used in each embodiment are the same.

[0037] Example 1 A composition with the function of assisting in lowering blood lipids, comprising, by weight: 9 parts hawthorn, 9 parts lotus leaf, 6 parts mulberry leaf and 1 part algal oil.

[0038] Hawthorn, lotus leaf, and mulberry leaf were decocted twice with 10 times the amount of water, each time for 1 hour. The extract was concentrated to 80% of its original volume, then centrifuged. The supernatant was collected and concentrated to 30% of the original extract volume. The extract was dried and mixed with algal oil to obtain the composition.

[0039] Example 2 A composition with the function of assisting in lowering blood lipids, comprising, by weight: 7 parts hawthorn, 7 parts lotus leaf, 4 parts mulberry leaf and 0.5 parts algal oil.

[0040] The preparation method is the same as in Example 1.

[0041] Example 3 A composition with the function of assisting in lowering blood lipids, comprising, by weight: 12 parts hawthorn, 12 parts lotus leaf, 9 parts mulberry leaf and 2 parts algal oil.

[0042] The preparation method is the same as in Example 1.

[0043] Comparative Example 1 Unlike Example 1, algal oil was replaced with perilla seed oil in the composition.

[0044] The composition consists of the following components by weight: 9 parts hawthorn, 9 parts lotus leaf, 6 parts mulberry leaf and 1 part perilla seed oil.

[0045] Hawthorn, lotus leaf, and mulberry leaf were decocted twice with 10 times the amount of water, each time for 1 hour. The extract was concentrated to 80% of its original volume, then centrifuged. The supernatant was collected and concentrated to 30% of the original extract volume. The extract was dried and mixed with perilla seed oil to obtain the composition.

[0046] Comparative Example 2 Unlike Example 1, the composition contains only the following components: 9 parts hawthorn and 6 parts mulberry leaves.

[0047] Hawthorn and mulberry leaves were decocted twice with 10 times the amount of water, each time for 1 hour. The extract was concentrated to 80% of its original volume, then centrifuged. The supernatant was collected and concentrated to 30% of the original extract volume. The mixture was then dried to obtain the final composition.

[0048] Comparative Example 3 Unlike Example 1, the composition contains only the following components: 9 parts lotus leaf and 1 part algal oil.

[0049] The lotus leaves were boiled twice with 10 times the amount of water, each time for 1 hour. The extract was concentrated to 80% of its original volume, then centrifuged. The supernatant was collected and concentrated to 30% of the original extract volume. The extract was dried and mixed with algal oil to obtain the composition.

[0050] Comparative Example 4 Unlike Example 1, the composition also includes the following components: mulberry, kudzu root and buckwheat.

[0051] The composition, with components by weight: 9 parts of hawthorn, 9 parts of lotus leaf, 6 parts of mulberry leaf, 1 part of algal oil, 9 parts of mulberry fruit, 9 parts of kudzu root, and 9 parts of buckwheat.

[0052] Boil and extract hawthorn, lotus leaf, mulberry leaf, mulberry fruit, kudzu root, and buckwheat with 10 times the amount of water for 2 times, 1 hour each time. Concentrate the extract to 80% of the original volume, then centrifuge, take the supernatant and continue to concentrate to 30% of the original extract volume, dry, and mix with algal oil to obtain the composition.

[0053] Comparative Example 5 The difference from Example 1 is that the weight parts of each component in the composition are different.

[0054] The composition, with components by weight: 5 parts of hawthorn, 5 parts of lotus leaf, 2 parts of mulberry leaf, and 2 parts of algal oil.

[0055] The rest are the same as in Example 1.

[0056] Technical effect detection 1. Samples Positive control: Fish oil EPA, specification: 100 capsules / bottle, 560 mg / capsule, manufacturer: BY-HEALTH Co., Ltd., expiration date: April 22, 2026, storage conditions: room temperature, protected from light, sealed.

[0057] The compositions prepared in Examples 1 - 3 and Comparative Examples 1 - 5.

[0058] 2. Test animals 110 SPF-grade male SD rats, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., production license number of experimental animals: SCXK(Hunan)2021 - 0002, quality certificate number of experimental animals: 430727241102094826. The animals were housed in Area D of the barrier environment animal laboratory of our company, experimental animal use license number: SYXK(Hunan)2020 - 0015, laboratory temperature range: 20.0 - 26.0 °C, relative humidity range: 40% - 70%, light: 12h / 12h light / dark alternation. High-fat feed, batch number: 20240004, adding 20.0% sucrose, 15.0% lard, 1.2% cholesterol, 0.2% sodium cholate, and appropriate amounts of casein, calcium hydrogen phosphate, stone powder, etc. to the maintenance feed.

[0059] The animals were conventionally raised, with free access to food and water, and all animals started the experiment after adaptive feeding.

[0060] 3. Test methods After 5 days of acclimatization, SD rats were randomly divided into two groups based on body weight. The first group (n=10) was given a maintenance diet as a blank control group; the second group (n=100) was given a model diet. Body weight was measured weekly. Two weeks after the model group was given the model diet, blood was collected from the jugular venous plexus of the rats without fasting. Serum was separated as soon as possible after blood collection, and serum TC, TG, LDL-C, and HDL-C levels were measured. Based on TC levels and body weight, the rats in the second group were randomly divided into 10 subgroups: the model control group, the 96% fish oil EPA group (positive control group), Example 1-Example 3 groups, and Comparative Examples 1-Comparative Examples 5 groups; the blank control group served as the solvent control group. Each subgroup consisted of 10 rats, and the remaining animals were transferred to the animal management department. Each group was administered the corresponding composition orally via gavage at a dose of 5 mL / kg bw (concentration 0.45 g / mL) for 45 consecutive days. The solvent control group and the model control group received the same volume of physiological saline. Twenty-four hours after the last sample administration, blood was collected from rats without fasting to separate serum. Serum levels of TC, TG, LDL-C, HDL-C, and GLU (fasting) were measured using a biochemical analyzer. Blood was also collected from the abdominal aorta after fasting, and serum levels of Apo-A1, Apo-B, SOD, and GSH were measured by ELISA.

[0061] 4. Main reagents TC detection kits (batch numbers: 310436, 304222), TG detection kits (batch numbers: 309409, 405968), LDL-C detection kits (batch number: 311470), HDL-C detection kits (batch number: 311475), and GLU detection kits (batch number: 310437) were all purchased from Wako Pure Chemical Industries, Ltd., Japan; Rat Apo-A1 Elisa Kits (batch number: 202409), Apo-B Elisa Kits (batch number: 202409), Rat SOD Elisa Kits (batch number: 202409), and Rat GSH Elisa Kits (batch number: 202409) were all purchased from Huangshi Ains Biotechnology Co., Ltd.

[0062] 5. Main Instruments ME2002E / 02 electronic balance, Mettler Toledo Instruments (Shanghai) Co., Ltd.; LABOSPECT003 automated biochemical analyzer, Hitachi, Japan; L530 benchtop low-speed centrifuge, Hunan Xiangyi Laboratory Instrument Development Co., Ltd.; TDZ5-WS benchtop multi-tube automatic balancing centrifuge, Changsha Pingfan Instrument Co., Ltd.; Spectra Max i3x multi-functional microplate reader, Meigu Molecular Instruments (Shanghai) Co., Ltd.

[0063] 6. Test Results 6.1 Effects on the general condition and body weight of model rats No obvious abnormalities were observed in the mental state, behavior, food and water intake, feces, urine, and secretions from any of the experimental animals. As shown in Table 1 (n=10, ...). W1-W7 represent weeks 1-7. Compared with the solvent control group (blank control group), there was no statistically significant difference in the initial weight of animals in the W1 group (P>0.05). Compared with the model control group, the weight of animals in the W7 group of Example 1 was significantly reduced (P≤0.05), and there was no statistically significant difference in the weight (g) of animals in the other groups (P>0.05).

[0064] Table 1

[0065] Note: Compared with the model control group, + P≤0.05.

[0066] 6.2 Effects on blood lipid levels in model rats As shown in Table 2 (n=10, Compared with the blank control group, the rats in the model control group showed significantly increased TC, TG, and LDL-C (P≤0.05 or P≤0.01), and significantly decreased HDL-C (P≤0.01), indicating that the mixed hyperlipidemia animal model was successfully established in this experiment. Compared with the model control group, the rats in Examples 1-3 and Comparative Example 4 showed significantly decreased TC (P≤0.05), and the rats in Examples 1-2 and Comparative Example 4 showed significantly decreased TG (P≤0.05). The regression of Examples 1-3 was closer to that of the blank control group than that of Comparative Example 4. The rats in Example 1 showed significantly decreased LDL-C (P≤0.05), and the rats in Examples 1-3 showed significantly increased HDL-C (P≤0.05). No statistically significant differences were found in any of the indicators in the other groups (P>0.05).

[0067] Table 2

[0068] Note: Compared with the blank control group, # P≤0.05, ## P≤0.01; compared with the model control group, + P≤0.05.

[0069] 6.3 Effects on serum related indicators in model rats As shown in Table 3 (n=10, Compared with the blank control group, the serum Apo-A1 level in the model control group was significantly decreased (P≤0.01), while Apo-B and GLU levels were significantly increased (P≤0.05 or P≤0.01). Compared with the model control group, serum Apo-B levels in groups 1-3 were significantly decreased (P≤0.05 or P≤0.01), while serum Apo-A1 levels in group 1 were significantly increased (P≤0.05). Serum GLU levels in groups 1-3 were significantly decreased (P≤0.05 or P≤0.01). No statistically significant differences were observed in any of the other indicators among the drug administration groups (P>0.05).

[0070] Table 3

[0071] Note: Compared with the blank control group, # P≤0.05, ## P≤0.01; compared with the model control group, + P≤0.05, ++ P≤0.01.

[0072] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A composition having an auxiliary effect in lowering blood lipids, characterized in that, It is composed of the following components: hawthorn, lotus leaf, mulberry leaf and algal oil.

2. The composition according to claim 1, characterized in that, By weight, it consists of the following components: 7-12 parts hawthorn, 7-12 parts lotus leaf, 4-9 parts mulberry leaf and 0.5-2 parts algal oil.

3. The composition according to claim 2, characterized in that, By weight, it consists of the following components: 9 parts hawthorn, 9 parts lotus leaf, 6 parts mulberry leaf and 1 part algal oil.

4. A method for preparing the composition according to any one of claims 1-3, characterized in that, The steps include: boiling hawthorn, lotus leaf, and mulberry leaf in water to extract the extract, concentrating the extract, and then mixing it with algal oil to obtain a composition.

5. The preparation method according to claim 4, characterized in that, During the extraction process, the amount of water added should be 5-15 times the weight of hawthorn, lotus leaf, and mulberry leaf; the decoction should be performed 1-3 times, each time for 0.5-2 hours.

6. The preparation method according to claim 4, characterized in that, The concentration of the extract is divided into two steps: first, the extract is concentrated to 70%-90% of its original volume, then centrifuged, and the supernatant is taken and concentrated to 20%-40% of the original extract volume.

7. The use of the composition according to any one of claims 1-3 or the composition prepared by the preparation method according to any one of claims 4-6 in the preparation of lipid-lowering drugs and / or health foods.

8. A lipid-lowering drug, characterized in that, Includes the following components: the composition according to any one of claims 1-3 or the composition prepared by the preparation method according to any one of claims 4-6.

9. A lipid-lowering health food, characterized in that, Includes the following components: the composition according to any one of claims 1-3 or the composition prepared by the preparation method according to any one of claims 4-6.

10. The method for preparing the lipid-lowering drug of claim 8 or the lipid-lowering health food of claim 9, characterized in that, The process includes the following steps: boiling hawthorn, lotus leaf, and mulberry leaf in water to extract the lipids, concentrating the extract, mixing it with maltodextrin, and then mixing it with algal oil to obtain lipid-lowering drugs or lipid-lowering health foods.

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