A spinal cord electrical stimulation system

Abstract

The present application relates to a kind of spinal cord electrical stimulation systems, comprising: in-vivo electrode, the in-vivo electrode is used to implant target position of spinal cord, the in-vivo electrode is provided with at least one signal transmitting device;Pulse generator, the pulse generator is electrically connected to the in-vivo electrode;Multiple external detectors, the external detector of the described is attached in the position of target spine posterior of organism back, multiple the external detector of the described is arranged in matrix, any one external detector includes a signal receiving device, a signal processing device and a signal indicating device.The present application is attached in the position corresponding to spinal cord in the back of organism with multiple external detectors, and takes X-ray image, obtains the corresponding relationship of external detector and spine, so as to be able to locate the specific position of spine, after obtaining X-ray image, it is no longer needed to use X-ray to guide puncture electrode, greatly reduce the time of patient and doctor being X-ray radiation, so as to reduce the harm of X-ray radiation.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of human life supplies, in particular to medical devices, and particularly to a spinal cord electrical stimulation system. BACKGROUND

[0002] Spinal cord electrical stimulation therapy is a rapidly developing frontier neural electrical regulation treatment method, and the current mainstream design is an implantable spinal epidural electrical stimulation system.

[0003] In the prior art, the implantable spinal epidural electrical stimulation system requires a doctor to check the real-time position of the implanted stimulation electrode in the body by X-ray to accurately implant the stimulation electrode into the target position, and to generate a stimulation signal by using the stimulation electrode to electrically stimulate the spinal cord at the target position. The entire treatment process requires X-ray fluoroscopy and patient feedback to confirm the position of the electrode, and a relatively long time is required. The longer the time, the greater the harm caused by X-rays to the doctor and the patient. SUMMARY

[0004] The purpose of the present application is to provide a spinal cord electrical stimulation system that addresses the technical problem of long X-ray exposure time for doctors and patients during implantation of the stimulation electrode in the prior art.

[0005] The spinal cord electrical stimulation system of the present application comprises an in-vivo electrode for implanting into a target position of the spinal cord, the in-vivo electrode being provided with at least one signal emitting device; a pulse generator electrically connected to the in-vivo electrode through a connecting lead; a plurality of external detectors attached to the position of the target spinal column on the back of the organism, the plurality of external detectors being arranged in a matrix, any one of the external detectors comprising a signal receiving device, a signal processing device and a signal indicating device, the signal emitting device being connected to the signal receiving device through wireless signals, the output end of the signal receiving device being electrically connected to the input end of the signal processing device, and the output end of the signal processing device being electrically connected to the input end of the signal indicating device.

[0006] Preferably, the signal indicating device is a light emitting device.

[0007] Preferably, the light emitting device comprises a first LED lamp, a second LED lamp and a third LED lamp; the signal processing device is configured to: the signal receiving device acquires the positioning signal emitted by the signal emitting device, the signal processing device judges the size result of the strength of the acquired positioning signal and the first reference value and the second reference value; a first light emitting signal is generated when the strength of the acquired positioning signal is less than the first reference value, and the first light emitting signal is sent to the first LED lamp; a second light emitting signal is generated when the strength of the acquired positioning signal is greater than the first reference value and less than the second reference value, and the second light emitting signal is sent to the second LED lamp; a third light emitting signal is generated when the acquired positioning signal is greater than the second reference value, and the second light emitting signal is sent to the third LED lamp; the first LED lamp is configured to generate light under the control of the first light emitting signal; the second LED lamp is configured to generate light under the control of the second light emitting signal; the third LED lamp is configured to generate light under the control of the third light emitting signal; wherein the first reference value is less than the second reference value, and the colors of the light generated by the first LED lamp, the second LED lamp and the third LED lamp are different.

[0008] Preferably, the first LED lamp generates yellow light, the second LED lamp generates green light, and the third LED lamp generates blue light.

[0009] Preferably, it further comprises an extracorporeal controller configured to generate a control signal and send the control signal to the pulse generator, and the pulse generator generates the predetermined stimulation signal under the control of the control signal.

[0010] Preferably, the signal receiving device comprises a coil; the signal processing device comprises a first low-pass filter, a signal gain adjuster, an ADC sampling signal device, a first multiplier, a second low-pass filter, a phase detector, a second multiplier, a third low-pass filter, a loop filter, a digital controlled oscillator, an adder, a threshold decision device, a logic judgment module; the signal indicating device comprises a first LED driving module, a second LED driving module, a third LED driving module, a first LED lamp, a second LED lamp and a third LED lamp.

[0011] Preferably, the output end of the coil is electrically connected to the input end of the first low-pass filter; the output end of the first low-pass filter is electrically connected to the input end of the signal gain adjuster; the output end of the signal gain adjuster is electrically connected to the input end of the ADC sampling signaler; the first output end of the ADC sampling signaler is electrically connected to the first input end of the first multiplier, and the second output end of the ADC sampling signaler is electrically connected to the first input end of the second multiplier; the output end of the first multiplier is electrically connected to the input end of the second low-pass filter; the first output end of the second low-pass filter is electrically connected to the first input end of the phase detector, and the second output end of the second low-pass filter is electrically connected to the first input end of the adder; the output end of the second multiplier is electrically connected to the input end of the third low-pass filter.

[0012] Preferably, the first output end of the third low-pass filter is electrically connected to the second input end of the phase detector, and the second output end of the third low-pass filter is electrically connected to the second input end of the adder; the output end of the phase detector is electrically connected to the input end of the loop filter; the output end of the loop filter is electrically connected to the input end of the numerically controlled oscillator; the first output end of the numerically controlled oscillator is electrically connected to the second input end of the first multiplier, and the second output end of the numerically controlled oscillator is electrically connected to the second input end of the second multiplier; the output end of the adder is electrically connected to the input end of the threshold decision device; the output end of the threshold decision device is electrically connected to the input end of the logic judgment module; the output end of the logic judgment module is electrically connected to the input end of the LED driving module.

[0013] Preferably, the output end of the logic judgment module is electrically connected to the input end of the first LED driving module, the second LED driving module, and the third LED driving module; the output end of the first LED driving module is electrically connected to the input end of the first LED lamp; the output end of the second LED driving module is electrically connected to the input end of the second LED lamp; the output end of the third LED driving module is electrically connected to the input end of the third LED lamp.

[0014] Preferably, a visible mark is arranged on the in-vitro detector for clearly identifying the corresponding relationship between the in-vitro detector and the spinal structure in surgery.

[0015] The working process of the present application is as follows: a plurality of external detectors are attached to the back of the organism corresponding to the target spine, and an X-ray image is taken to obtain the correspondence between the external detector and the spine, the target position corresponding external detector is determined, the signal emitting device of the in-vivo electrode emits a positioning signal during the implantation of the in-vivo electrode, the positioning signal is sent to the signal receiving device of the external detector in a wireless transmission manner, the signal processing device controls the corresponding signal indicating device to respond after processing the received signal, and the position of the electrode and the implantation depth of the electrode can be judged through the response of the signal indicating device.

[0016] The present application has positive and obvious effects compared with the prior art. The present application attaches a plurality of external detectors to the back of the organism corresponding to the target spine, and takes an X-ray image to obtain the correspondence between the external detector and the spine, so that the specific position of the spine can be located, and after obtaining the X-ray image, the in-vivo electrode is directly implanted under the assistance of the X-ray image without X-ray irradiation, thereby greatly reducing the time of X-ray irradiation of the patient and the doctor, and reducing the harm of X-ray irradiation. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of the spinal cord electric stimulation system of the present application;

[0018] Figure 2 It is a schematic diagram of attaching a plurality of external detectors to the back of the patient;

[0019] Figure 3 It is an X-ray image obtained after attaching a plurality of external detectors in the present application;

[0020] Figure 4 It is an in-vivo electrode implantation schematic diagram;

[0021] Figure 5a It is a light-emitting schematic diagram when the in-vivo electrode is implanted at a normal position;

[0022] Figure 5b It is a light-emitting schematic diagram when the in-vivo electrode is implanted at a right-biased position;

[0023] Figure 5c It is a light-emitting schematic diagram when the in-vivo electrode is implanted at a left-biased position;

[0024] Figure 5d It is a light-emitting schematic diagram when the in-vivo electrode is implanted at a deep-biased position;

[0025] Figure 5e It is a light-emitting schematic diagram when the in-vivo electrode is implanted at a shallow-biased position;

[0026] Figure 6 It is a partial circuit schematic diagram in the external detector;

[0027] Figure 7 For Figure 6 the analog signal received by the coil;

[0028] Figure 8 For Figure 6 the analog signal received by the ADC signal sampler;

[0029] Figure 9 For Figure 6 the digital signal received by the LED lamp.

[0030] Figure Marked: 100, external detector; 200, internal electrode; 300, pulse generator; 400, external controller; 500, connecting wire; 111, coil; 112, first low-pass filter; 113, signal gain adjuster; 114, ADC signal sampler; 115, first multiplier; 116, second low-pass filter; 117, phase detector; 118, second multiplier; 119, third low-pass filter; 120, loop filter; 121, digitally controlled oscillator; 122, adder; 123, threshold decision maker; 124, logic judgment module; 125, first LED driving module; 126, first LED lamp; 127, second LED lamp; 128, second LED driving module; 129, third LED lamp; 130, third LED driving module. DETAILED DESCRIPTION

[0031] Reference will now be made in detail to various embodiments of the present application, examples of which are illustrated in the accompanying drawings and described below. While the present application will be described in conjunction with the exemplary embodiments, it should be understood that the present application is not limited to these exemplary embodiments. On the contrary, the present application is intended to cover all alternatives, modifications, equivalents and other embodiments that can be included within the spirit and scope of the present application as defined by the appended claims.

[0032] Figure 1 For the structural schematic diagram of the spinal cord electrical stimulation system of the present application; Figure 2 For the schematic diagram of attaching multiple external detectors on the back of a patient; Figure 3 For the X-ray image obtained by the present application after attaching multiple external detectors; Figure 4 For the light-emitting schematic diagram when the internal electrode is implanted at position A19; Figure 5 is the light-emitting schematic diagram when the internal electrode is implanted at position A6; Figure 6 For the schematic diagram of part of the circuit in the external detector; Figure 7 For Figure 6 the analog signal received by the coil; Figure 8 For Figure 6The analog signal received by the middle ADC sampling signal device 114; Figure 9 For Figure 6 The digital signal received by the LED lamp.

[0033] The following will be combined Figures 1 to 9 The spinal cord electrical stimulation system of the present application is described.

[0034] As Figure 1 shown, the spinal cord electrical stimulation system of the present application comprises:

[0035] An in-vivo electrode 200, said in-vivo electrode 200 is used to implant in the target position of the spinal cord, said in-vivo electrode 200 is provided with at least one signal emitting device;

[0036] A pulse generator 300, said pulse generator 300 is electrically connected to said in-vivo electrode 200 through a connecting lead 500;

[0037] A plurality of external detectors 100, said external detectors 100 are attached to the target position of the posterior side of the spine on the back of the organism, a plurality of said external detectors 100 are arranged in a matrix, any one of said external detectors 100 comprises a signal receiving device, a signal processing device and a signal indicating device, said signal emitting device and said signal receiving device are connected through wireless signal, the output end of said signal receiving device is electrically connected to the input end of the signal processing device, the output end of said signal processing device is electrically connected to the input end of the signal indicating device.

[0038] As Figure 2 shown, after attaching the external detector 100 to the corresponding position of the target vertebra on the back of the organism, taking X-ray image with medical X-ray machine, as Figure 3 shown, the spine and the external detector 100 are imaged together, the corresponding relationship between the external detector 100 and the vertebra can be obtained; as Figure 4 -As shown in Fig. 5, during the process of implanting the in-vivo electrode 200 into the spinal cord, the signal emitting device constantly emits positioning signal, the positioning signal is sent to the signal receiving device of the external detector 100 in a wireless transmission manner, since the strength of the wireless signal attenuates with distance, after the external detector 100 close to the in-vivo electrode 200 receives the positioning signal, the corresponding signal indicating device responds, through the signal indicating device, the position of the electrode and the depth of the electrode implantation can be judged, so that the position of the electrode can be accurately positioned.

[0039] After the internal electrode 200 is implanted at the target location in the spinal cord, the pulse generator 300 generates a predetermined stimulation signal and sends the predetermined stimulation signal to the internal electrode 200, causing the internal electrode 200 to release the predetermined stimulation signal to electrically stimulate the spinal cord at the target location. Specifically, the pulse generator 300 is electrically connected to the internal electrode 200 via a connecting wire 500.

[0040] This invention attaches multiple external detectors 100 to the back of an organism at positions corresponding to the spinal cord and captures X-ray images to obtain the correspondence between the external detectors 100 and the spine, thereby enabling the precise location of the spine. After acquiring the X-ray images, there is no need for X-ray irradiation; the internal electrodes 200 are implanted directly with the assistance of the X-ray images, greatly reducing the time that patients and doctors are exposed to X-rays, thus reducing the harm caused by X-ray irradiation.

[0041] by Figure 2 Taking Figure 5 as an example, 28 external detectors 100 were attached to the patient's back and labeled as A1, A2, A3, ..., D7. In the X-ray images, the correspondence between the spinal nerve roots in the spinal cord and each external detector 100 can be directly seen. Assuming that the location to be treated corresponds to C3, the doctor only needs to implant the internal electrode 200 into the spinal cord corresponding to the external detector marked C3.

[0042] In an exemplary embodiment, the signal transmitting device of the in vivo electrode 200 can output a positioning signal during the implantation process and transmit the positioning signal wirelessly to the signal receiving device of the external detector 100. The signal indicating device can be a light-emitting device. After receiving the positioning signal, the external detector 100, which is closer to the in vivo electrode 200, can make the corresponding light-emitting device light up to help the doctor obtain the real-time position of the in vivo electrode 200, thereby helping the doctor to determine whether the in vivo electrode 200 has been implanted into the target position.

[0043] In an exemplary embodiment, the signal indicating device of the external detector 100 that receives the positioning signal can generate different lights according to the intensity of the received positioning signal, thereby determining the location of the internal electrode 200 based on the light emitted by the signal indicating device.

[0044] In one possible implementation, the different lights can be different colors of light. For example, the external detector 100 that receives the positioning signal can generate different colors of light according to the intensity of the received positioning signal.

[0045] Specifically, one external detector 100 includes a signal processing device and three LED lamps, the three LED lamps including a blue LED lamp, a green LED lamp and a yellow LED lamp, the signal processing device acquires a positioning signal and judges whether the acquired positioning signal exceeds a first reference value.

[0046] In response to the acquired positioning signal not exceeding the first reference value, the signal processing device generates a first light-emitting signal and sends the first light-emitting signal to the yellow LED lamp, so that the yellow LED lamp generates yellow light.

[0047] In response to the acquired positioning signal being between the first reference value and a second reference value, the signal processing device generates a second light-emitting signal and sends the second light-emitting signal to the green LED lamp, so that the green LED lamp generates green light.

[0048] In response to the acquired positioning signal exceeding the second reference value, the signal processing device generates a third light-emitting signal and sends the third light-emitting signal to the blue LED lamp, so that the blue LED lamp generates blue light.

[0049] It should be understood that here, only yellow, green and yellow light is taken as an example, and other colors of light can also be selected according to actual design requirements.

[0050] The spinal cord electrical stimulation system of the embodiment of the present application further includes an external controller 400.

[0051] The external controller 400 can send a control signal to the pulse generator 300 through wireless communication, so that the pulse generator 300 generates a predetermined stimulation signal for stimulating the spinal cord of the target organism, wherein the predetermined stimulation signal is an adjustable parameter electrical pulse signal.

[0052] The pulse generator 300 can be implanted in the target organism in whole or in part through surgery, for example, the pulse generator 300 can be implanted in the lower abdomen or upper buttocks of the patient in whole. The pulse generator 300 can receive the control signal from the external controller 400 and generate the predetermined stimulation signal corresponding to the control signal. The pulse generator 300 and the external controller 400 can communicate via wireless communication using any technology known in the art.

[0053] The connecting lead 500 can include an internal lead and an insulating coating, the internal lead being wrapped inside the insulating coating.

[0054] The inner wire is made of a conductive material, such as magnesium, and can meet the use requirement of conductivity. The insulating coating is made of an insulating material, such as polylactic acid, and can meet the use requirement of insulation, corrosion resistance and biocompatibility.

[0055] In further embodiments, as shown in FIG. 1, the in-vitro detector 100 includes a coil 111, a first low-pass filter 112, a signal gain adjuster 113, an ADC sampling signaler 114, a first multiplier 115, a second low-pass filter 116, a phase detector 117, a second multiplier 118, a third low-pass filter 119, a loop filter 120, a digital controlled oscillator 121, a summer 122, a threshold decision maker 123, a logic decision module 124, a first LED driving module 125, a second LED driving module 128, a third LED driving module 130, a first LED lamp 126, a second LED lamp 127, and a third LED lamp 129. Figure 6

[0056] The output end of the coil 111 is electrically connected to the input end of the first low-pass filter 112.

[0057] The output end of the first low-pass filter 112 is electrically connected to the input end of the signal gain adjuster 113. The output end of the signal gain adjuster 113 is electrically connected to the input end of the ADC sampling signaler 114.

[0058] The first output end of the ADC sampling signaler 114 is electrically connected to the first input end of the first multiplier 115, and the second output end of the ADC sampling signaler 114 is electrically connected to the first input end of the second multiplier 118.

[0059] The output end of the first multiplier 115 is electrically connected to the input end of the second low-pass filter 116.

[0060] The first output end of the second low-pass filter 116 is electrically connected to the first input end of the phase detector 117, and the second output end of the second low-pass filter 116 is electrically connected to the first input end of the summer 122.

[0061] The output end of the second multiplier 118 is electrically connected to the input end of the third low-pass filter 119.

[0062] The first output end of the third low-pass filter 119 is electrically connected to the second input end of the phase detector 117, and the second output end of the third low-pass filter 119 is electrically connected to the second input end of the summer 122.

[0063] The output end of the phase detector 117 is electrically connected to the input end of the loop filter 120.

[0064] ​An output end of the loop filter 120 is electrically connected to an input end of the digital controlled oscillator 121.

[0065] A first output end of the digital controlled oscillator 121 is electrically connected to a second input end of the first multiplier 115, and a second output end of the digital controlled oscillator 121 is electrically connected to a second input end of the second multiplier 118.

[0066] An output end of the adder 122 is electrically connected to an input end of the threshold decision maker 123.

[0067] An output end of the threshold decision maker 123 is electrically connected to an input end of the logic decision module 124.

[0068] An output end of the logic decision module 124 is electrically connected to input ends of the first LED driving module 125, the second LED driving module 128 and the third LED driving module 130.

[0069] An output end of the first LED driving module 125 is electrically connected to an input end of the first LED lamp 126.

[0070] An output end of the second LED driving module 128 is electrically connected to an input end of the second LED lamp 127.

[0071] An output end of the third LED driving module 130 is electrically connected to an input end of the third LED lamp 129.

[0072] The positioning signal emitted by the signal emitting device of the in-vivo electrode 200 can be an analog signal, which is propagated through electromagnetic radiation. The coil 111 receives the analog signal (see Figure 7 for details) and filters the analog signal through the first low-pass filter 112 to obtain a low-frequency signal. The low-frequency signal is processed by the signal gain adjuster 113 to increase the amplitude, and a low-frequency analog signal with increased amplitude is obtained (see Figure 8 for details).

[0073] The analog signal is processed by the ADC sampling signal device 114 to become a digital signal.

[0074] The first multiplier 115, the second low-pass filter 116, the phase discriminator 117, the second multiplier 118, the third low-pass filter 119, the loop filter 120 and the digital controlled oscillator 121 constitute a quadrature demodulation module.

[0075] The digital signal no longer contains bioelectricity after being quadrature demodulated by the quadrature demodulation module.

[0076] The sine signal outputted by the first output end of the numerically controlled oscillator 121 is multiplied with the output signal of the ADC sampling signal device 114, and then passes through the second low-pass filter 116, the phase detector 117 and the loop filter 120 to return to the numerically controlled oscillator 121 to form a loop.

[0077] The cosine signal outputted by the second output end of the numerically controlled oscillator 121 is multiplied with the output signal of the ADC sampling signal device 114, and then passes through the third low-pass filter 119, the phase detector 117 and the loop filter 120 to return to the numerically controlled oscillator 121 to form a loop, i.e. quadrature demodulation.

[0078] The analog signal of the coil 111 does not contain bioelectricity after being filtered by the first low-pass filter 112 and the quadrature demodulation module, so that the interference of bioelectricity and biomagnetic field on the spinal cord electric stimulation system of the present application is eliminated.

[0079] The first LED lamp 126, the second LED lamp 127 and the third LED lamp 129 emit light under the control of the digital signal (see Figure 9 ).

[0080] The extracorporeal detector 100 further comprises a partial power supply circuit (not shown in the figure) to supply power to the coil 111, the first low-pass filter 112, the signal gain adjuster 113, the ADC sampling signal device 114, the first multiplier 115, the second low-pass filter 116, the phase detector 117, the second multiplier 118, the third low-pass filter 119, the loop filter 120, the numerically controlled oscillator 121, the adder 122, the threshold decision device 123, the logic judgment module 124, the LED driving module 125 and the LED lamp 126.

[0081] In a preferred embodiment of the present application, the extracorporeal detector 100 is provided with a visible mark to clearly identify its correspondence with the spinal structure during surgery.

[0082] The operation of the spinal cord electric stimulation system of the present application will be described below in combination with the accompanying drawings.

[0083] A plurality of extracorporeal detectors 100 are attached to the skin corresponding to the target spine on the back of the patient (see Figure 2 ).

[0084] The patient takes X-ray in a short time to obtain an X-ray image, and then obtains the correspondence between the extracorporeal detector 100 and the spine (see Figure 3 ). This process only requires the patient to be exposed to X-ray for 1s, which greatly reduces the harm of X-ray to the patient compared with the prior art.

[0085] According to Figure 3The doctor can know the position of the spinal cord corresponding to the target position from the X-ray image. It is assumed that the target position is the position of the external detector 100 marked as B3, C3.

[0086] After obtaining the X-ray image, the doctor can know the position of the spinal cord corresponding to the target position from the X-ray image. It is assumed that the target position is the position of the external detector 100 marked as B3, C3. Figure 4 The internal electrode 200 is implanted into the target spine of the patient through surgery.

[0087] During the implantation process, the signal emitting device of the internal electrode 200 can output a positioning signal and send the positioning signal to the signal receiving device of the external detector 100 near the internal electrode 200 in a wireless transmission manner. The external detector 100 receiving the positioning signal can emit light to help the doctor obtain the real-time position of the internal electrode 200, so as to help the doctor judge whether the internal electrode 200 has been implanted into the target position.

[0088] During the implantation process, the signal emitting device of the internal electrode 200 can output a positioning signal and send the positioning signal to the signal receiving device of the external detector 100 near the internal electrode 200 in a wireless transmission manner. The external detector 100 receiving the positioning signal can emit light to help the doctor obtain the real-time position of the internal electrode 200, so as to help the doctor judge whether the internal electrode 200 has been implanted into the target position.

[0089] During the implantation process, the signal emitting device of the internal electrode 200 can output a positioning signal and send the positioning signal to the signal receiving device of the external detector 100 near the internal electrode 200 in a wireless transmission manner. The external detector 100 receiving the positioning signal can emit light to help the doctor obtain the real-time position of the internal electrode 200, so as to help the doctor judge whether the internal electrode 200 has been implanted into the target position. Figure 5a If the electrode position is normal, as shown in FIG. 4, when the internal electrode 200 passes through the positions of the external detectors 100 marked as B3, C3, the external detectors 100 marked as B3, C3 receive the normal positioning signal and generate green light.

[0090] If the electrode position is right, as shown in FIG. 5, when the internal electrode 200 passes through the positions of the external detectors 100 marked as C3, D3, the external detectors 100 marked as C3, D3 receive the normal positioning signal and generate green light. Figure 5b If the electrode position is left, as shown in FIG. 6, when the internal electrode 200 passes through the positions of the external detectors 100 marked as A3, B3, the external detectors 100 marked as A4, B4 receive the normal positioning signal and generate green light.

[0091] Figure 5c If the electrode position is deep, as shown in FIG. 7, when the internal electrode 200 passes through the positions of the external detectors 100 marked as A3, B3, the external detectors 100 marked as B3, C3 receive the deep positioning signal and generate yellow light.

[0092] If the electrode position is shallow, as shown in FIG. 8, when the internal electrode 200 passes through the positions of the external detectors 100 marked as A3, B3, the external detectors 100 marked as B3, C3 receive the shallow positioning signal and generate yellow light. Figure 5d If the electrode position is shallow, as shown in FIG. 8, when the internal electrode 200 passes through the positions of the external detectors 100 marked as A3, B3, the external detectors 100 marked as B3, C3 receive the shallow positioning signal and generate yellow light.

[0093] Figure 5e ​​As shown, when the in-vivo electrode 200 passes through the positions of the out-vivo detectors 100 marked as A3, B3, the out-vivo detectors 100 marked as B3, C3 receive the positioning signals with a distance bias and generate blue light.

[0094] According to the different color indications of the light emitting device of the out-vivo detector 100, the electrode can be adjusted to the correct position and depth, and the electrode can be adjusted to Figure 5a After the state shown, the control signal is generated by the out-vivo controller 400 and sent to the pulse generator 300, so that the pulse generator 300 generates a predetermined stimulation signal for stimulating the spinal nerve root of the target organism.

[0095] The pulse generator 300 sends the predetermined stimulation signal to the in-vivo electrode 200 through the connecting wire 500, so that the in-vivo electrode 200 releases the predetermined stimulation signal to electrically stimulate the spinal nerve root at the target position.

[0096] During the whole process, only the patient needs to be exposed to X-ray environment for about 1s, which greatly reduces the harm of X-ray to the patient. And the doctor does not need to be exposed to X-ray environment, avoiding the harm of X-ray to the doctor.

[0097] For the convenience of explanation and accurate definition of the appended claims, the terms "upper", "lower", "inner", "outer", "upper", "lower", "upper", "lower", "upward", "downward", "front", "back", "back", "inner", "outer", "inward", "outward", "inner", "outer", "inner", "outer", "inner", "outer", "forward", "backward" are used to describe the features of the exemplary embodiments with reference to the positions of these features shown in the drawings.

[0098] The foregoing description of specific exemplary embodiments of the present application is presented for the purposes of illustration and description. The foregoing description is not intended to be exhaustive or to be limited to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teachings. The exemplary embodiments were chosen and described in order to explain the principles of the application and its practical application to thereby enable others skilled in the art to best utilize the application and various embodiments with various modifications as are suited to the particular use contemplated. The scope of the application is defined by the following claims and their equivalents.

Claims

1. A spinal cord electrical stimulation system characterized by, The application relates to a spinal cord electric stimulation system, which comprises the following parts: an in-vivo electrode, which is used for implanting a target position of a spinal cord, and is provided with at least one signal emitting device; a pulse generator, which is electrically connected to the in-vivo electrode through a connecting wire; a plurality of in-vitro detectors, which are attached to the positions of the target spinal column on the back of a living body, and are arranged in a matrix, wherein any one of the in-vitro detectors comprises a signal receiving device, a signal processing device and a signal indicating device, the signal emitting device is connected to the signal receiving device through wireless signals, the output end of the signal receiving device is electrically connected to the input end of the signal processing device, and the output end of the signal processing device is electrically connected to the input end of the signal indicating device; the signal indicating device is a light emitting device; the light emitting device comprises a first LED lamp, a second LED lamp and a third LED lamp; the signal processing device is configured as: the signal receiving device acquires a positioning signal emitted by the signal emitting device, and the signal processing device judges the comparison result of the strength of the acquired positioning signal and the first reference value and the second reference value; a first light emitting signal is generated when the strength of the acquired positioning signal is smaller than the first reference value, and the first light emitting signal is sent to the first LED lamp; a second light emitting signal is generated when the strength of the acquired positioning signal is greater than the first reference value and smaller than the second reference value, and the second light emitting signal is sent to the second LED lamp; a third light emitting signal is generated when the acquired positioning signal is greater than the second reference value, and the second light emitting signal is sent to the third LED lamp; the first LED lamp is configured to generate light under the control of the first light emitting signal; the second LED lamp is configured to generate light under the control of the second light emitting signal; the third LED lamp is configured to generate light under the control of the third light emitting signal; wherein the first reference value is smaller than the second reference value, and the colors of the light generated by the first LED lamp, the second LED lamp and the third LED lamp are different.

2. The spinal cord stimulation system of claim 1, wherein: The first LED lamp generates yellow light, the second LED lamp generates green light, and the third LED lamp generates blue light.

3. The spinal cord stimulation system of claim 1, wherein: The system further comprises an in-vitro controller, which is configured to generate a control signal and send the control signal to the pulse generator, and the pulse generator generates the predetermined stimulation signal under the control of the control signal.

4. The spinal cord stimulation system of claim 1, wherein: The signal receiving device comprises a coil; the signal processing device comprises a first low-pass filter, a signal gain adjuster, an ADC sampling signal device, a first multiplier, a second low-pass filter, a phase discriminator, a second multiplier, a third low-pass filter, a loop filter, a digital control oscillator, an adder, a threshold decision device and a logic judgment module; and the signal indicating device comprises a first LED driving module, a second LED driving module, a third LED driving module, a first LED lamp, a second LED lamp and a third LED lamp.

5. The spinal cord electric stimulation system according to claim 4, wherein: the output end of the coil is electrically connected to the input end of the first low-pass filter. An output terminal of the first low-pass filter is electrically connected to an input terminal of the signal gain adjuster; An output terminal of the signal gain adjuster is electrically connected to an input terminal of the ADC sampling signaler; A first output terminal of the ADC sampling signaler is electrically connected to a first input terminal of the first multiplier, and a second output terminal of the ADC sampling signaler is electrically connected to a first input terminal of the second multiplier; An output terminal of the first multiplier is electrically connected to an input terminal of the second low-pass filter; A first output terminal of the second low-pass filter is electrically connected to a first input terminal of the phase detector, and a second output terminal of the second low-pass filter is electrically connected to a first input terminal of the adder; An output terminal of the second multiplier is electrically connected to an input terminal of the third low-pass filter.

6. The spinal cord electrical stimulation system of claim 4, wherein: A first output terminal of the third low-pass filter is electrically connected to a second input terminal of the phase detector, and a second output terminal of the third low-pass filter is electrically connected to a second input terminal of the adder; An output terminal of the phase detector is electrically connected to an input terminal of the loop filter; An output terminal of the loop filter is electrically connected to an input terminal of the numerically controlled oscillator; A first output terminal of the numerically controlled oscillator is electrically connected to a second input terminal of the first multiplier, and a second output terminal of the numerically controlled oscillator is electrically connected to a second input terminal of the second multiplier; An output terminal of the adder is electrically connected to an input terminal of the threshold decision maker; An output terminal of the threshold decision maker is electrically connected to an input terminal of the logic decision module.

7. The spinal cord electrical stimulation system of claim 4, wherein: An output terminal of the logic decision module is electrically connected to input terminals of the first LED driving module, the second LED driving module and the third LED driving module; An output terminal of the first LED driving module is electrically connected to an input terminal of the first LED lamp; An output terminal of the second LED driving module is electrically connected to an input terminal of the second LED lamp; An output terminal of the third LED driving module is electrically connected to an input terminal of the third LED lamp.

8. The spinal cord stimulation system of claim 1 wherein: The extracorporeal detector is provided with a visual mark for identifying its corresponding relationship with the spinal structure in surgery.

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