Compound acupoint massage essential oil with olfactory and transdermal double effects for smoking control and preparation method thereof

Abstract

The application belongs to the technical field of traditional Chinese medicine, and discloses a kind of smelling and transdermal double-acting smoke control compound acupoint massage essential oil and preparation method thereof, the essential oil takes cinnamon essential oil as monarch drug, chamomile essential oil as ministerial drug, takes peppermint essential oil, limonene, linalool, vanillin, methyl cinnamate as auxiliary drug, and adds vitamin E, rosemary extract, eucalyptol, rose essential oil as auxiliary component.The application solves the core defects of existing essential oil smoke control products through scientific compatibility and process optimization, and each component synergistically inhibits monoamine oxidase activity and regulates dopamine level.Combined with traditional Chinese medicine acupoint massage and nasal smelling double absorption pathway, rapid effect and long-acting smoke control effect are achieved.The application solves the problems of poor user experience, poor stability, slow effect and insufficient targeting of existing smoke control essential oil, has the advantages of good smoke control effect, convenient use, wide applicability, high user acceptance and the like, and is beneficial to improving the success rate of smoking cessation.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a dual-action smoking cessation compound acupoint massage essential oil with both olfactory and transdermal effects, and its preparation method. Background Technology

[0002] Smoking is a globally recognized health hazard, and the development of tobacco control products has always been a hot topic in the industry. Current research shows that the effects of conventional tobacco control and cessation products are often unsustainable because quitting smoking is a comprehensive and multifaceted behavioral correction process. It requires combating nicotine dependence, overcoming psychological dependence on smoking, and resisting various environmental temptations. Most existing self-use products, when used alone, cause significant negative experiences, low acceptance, and reluctance to use continuously, resulting in poor sustainability and high relapse rates. While medications used in smoking cessation clinics are mostly bupropion hydrochloride and nicotine patches, which offer good short-term effects, they are also difficult to sustain long-term. For example, KR101126279B1 discloses a mixed essential oil composition and a method for preparing a smoking cessation aid using the composition. The mixed essential oil composition contains 25-35% bergamot oil, 20-30% coriander oil, 15-25% ginger oil, 5-20% sweet orange oil, and 5-20% lemon oil. It also provides toothpaste, sprays, and tube-shaped smoking cessation aids made using this mixed essential oil composition, including toothpaste, sprays, and pipe-type smoking cessation aids. However, this method easily triggers adverse reactions and negative emotions in users. US5592956A discloses a composition and method for suppressing tobacco cravings. Applying a mixture of clove oil, wintergreen oil, monosodium glutamate, Evodia rutaecarpa extract, and Ligusticum chuanxiong extract to specific acupoints can reduce or eliminate tobacco cravings. However, attempting to use tobacco can cause nausea, headaches, dizziness, vomiting, and other adverse reactions, and easily triggers psychological resistance in users. CN101502596A discloses a smoking cessation drug, which involves pulverizing various Chinese herbal medicine raw materials using a Chinese herbal medicine pulverizer and soaking them in 60-proof pure sorghum liquor. This drug produces an unacceptable odor, strange taste, or unique salty, bitter, or spicy taste in the user's mouth when they smoke, which can easily trigger negative feelings in the user and cause them to refuse to continue using it, thus failing to achieve the desired effect.

[0003] Acupressure and olfactory therapy, as traditional Chinese medicine treatments, have potential in smoking cessation. Compound essential oils, combining the effects of multiple essential oils, promise to be a safe and effective aid to smoking cessation through the dual effects of acupressure and olfactory inhalation. However, existing compound essential oils have shortcomings in user experience, synergistic effects, shelf life, and manufacturing processes. For example, some products are too irritating, leading to unpleasant user experiences; the synergistic effects between components are insufficient, resulting in poor smoking cessation effects; and the easy oxidation of essential oil components leads to a short shelf life, affecting product stability and effectiveness; unreasonable manufacturing processes may result in the loss of active ingredients and uneven system composition.

[0004] Therefore, existing essential oil-based smoking cessation products suffer from problems such as poor synergistic effects of components (not supporting dual-action synergy), poor product stability (volatile components are easily oxidized), slow onset of action (low transdermal efficiency), short duration of action (requiring frequent use), insufficient targeting (not covering the needs of different groups), and low acceptance (poor user experience, negative feelings, and difficulty in achieving sustained and long-term smoking cessation). Therefore, developing a smoking cessation essential oil with a good user experience, high product stability, rapid onset of action, long-lasting effect, and suitability for multiple types of people and scenarios is of great significance. Summary of the Invention

[0005] (a) Technical problems to be solved

[0006] The formula was designed based on the monarch-minister-assistant-guide compatibility model, and the synergistic effect of each component was improved to support the synergistic effect of olfactory and transdermal dual action;

[0007] To improve the stability of volatile components in essential oils and maintain their activity for a longer period of time, thereby extending their shelf life;

[0008] It enhances the efficiency of olfaction and transdermal absorption, shortens the onset time, and prolongs the duration of action;

[0009] Optimize the formula and mechanism of action to suit different groups and scenarios, and improve user experience, smoking control effect and usage compliance.

[0010] (II) Technical Solution

[0011] A dual-action (inhalation and transdermal) smoking-control compound acupressure massage essential oil is a high-concentration compound essential oil designed using a traditional Chinese medicine formula model. By weight percentage, it comprises the following components: 10%–30% cinnamon essential oil, 10%–25% chamomile essential oil, 3%–10% peppermint essential oil, 5%–15% limonene, 1%–4.5% linalool, 1%–6% vanillin, 3%–15% methyl cinnamate, and 20%–50% jojoba oil; auxiliary components include 0.3%–0.6% vitamin E, 0.3%–0.6% rosemary extract, 0%–0.1% eucalyptol, and 0%–0.6% rose essential oil; the sum of the weight percentages of all components is 100%.

[0012] Principal ingredient: 10%~30% cinnamon essential oil. The core component is cinnamaldehyde, which inhibits monoamine oxidase activity;

[0013] Medicated ingredients: 10%~25% chamomile essential oil, containing magnolol, which synergistically calms and enhances anti-inflammatory properties;

[0014] Adjuvant ingredients: peppermint essential oil 3%~10% (menthol promotes transdermal absorption), limonene 5%~15% (enhances monoamine oxidase inhibition), linalool 1%~4.5% (regulates mood), vanillin 1%~6% (harmonizes aroma), methyl cinnamate 3%~15% (strengthens aroma synergy);

[0015] Drug formulation: 20%~50% jojoba oil (as a base to achieve sustained release);

[0016] Co-ingredients: Vitamin E 0.3%~0.6%, Rosemary Extract 0.3%~0.6% (antioxidant), Eucalyptol 0~0.1% (enhances transdermal absorption), Rose Essential Oil 0~0.6% (optimizes aroma).

[0017] Its highly stable essential oil formula, by weight percentage, includes the following components: 10% cinnamon essential oil, 25% chamomile essential oil, 5% peppermint essential oil, 8% limonene, 2% linalool, 3% vanillin, 9% methyl cinnamate, 36.1% jojoba oil, 0.6% vitamin E, 0.6% rosemary extract, and 0.7% rose essential oil.

[0018] Its transdermal enhanced essential oil formula, by weight percentage, includes the following components: 30% cinnamon essential oil, 10% chamomile essential oil, 10% peppermint essential oil, 15% limonene, 1% linalool, 1% vanillin, 15% methyl cinnamate, 16.2% jojoba oil, 0.3% vitamin E, 0.3% rosemary extract, 0.1% eucalyptol, and 1% rose essential oil.

[0019] Its scent-enhancing essential oil formula, by weight percentage, includes the following components: 20% cinnamon essential oil, 20% chamomile essential oil, 3% peppermint essential oil, 5% limonene, 4.5% linalool, 6% vanillin, 3% methyl cinnamate, 37% jojoba oil, 0.4% vitamin E, 0.4% rosemary extract, and 0.7% rose essential oil.

[0020] Its balanced and enhanced essential oil formula, by weight percentage, includes the following components: 25% cinnamon essential oil, 15% chamomile essential oil, 8% peppermint essential oil, 12% limonene, 3% linalool, 2% vanillin, 12% methyl cinnamate, 21.7% jojoba oil, 0.5% vitamin E, 0.5% rosemary extract, 0.1% eucalyptol, and 0.5% rose essential oil.

[0021] The olfactory and transdermal dual-action smoking cessation compound acupressure massage essential oil is applied externally and massaged to the following acupoints for rapid effect: Neiguan, Hegu, Zusanli, Renzhong, ear acupoints, Fenglong, and Shenmen. Each acupoint massage lasts for 2-3 minutes to assist in smoking cessation and relieve discomfort caused by quitting smoking.

[0022] A method for preparing a dual-action (inhalation and transdermal) smoking-controlling acupoint massage essential oil, comprising the following steps:

[0023] (1) Take the amount of cinnamon essential oil, chamomile essential oil and jojoba oil according to the formula, add them to the reaction vessel, heat in a water bath at 50°C, stir at a rate of 200 r / min for 10 minutes to obtain a mixture;

[0024] (2) Add vanillin to the mixture in step (1) and stir for 5 minutes until completely dissolved. Then add methyl cinnamate and stir for another 5 minutes.

[0025] (3) Stop heating and let it cool naturally to 30°C. Add peppermint oil, limonene, linalool and the amount of auxiliary components in the formula. Stir at 300r / min for 15 minutes to mix the components evenly.

[0026] (4) The mixed essential oils are aseptically filled into brown glass dropper bottles and stored at 15-25°C away from light.

[0027] (III) Beneficial Effects

[0028] 1. The dual-action (inhalation and transdermal) smoking cessation compound acupressure massage essential oil provided by this invention, through the organic combination and synergy of multiple components, can be formulated into a series of dual-action acupressure massage essential oils. Through acupressure massage and inhalation, it can produce beneficial effects similar to smoking, generating a sense of pleasure similar to that after smoking, thereby reducing the craving for cigarettes and replacing the sensory experience of smoking. It helps smokers maintain mental clarity and alertness while replacing smoking, obtaining the beneficial consequences and pleasure equivalent to those obtained from smoking, thus reducing the frequency of smoking and gradually achieving the goal of quitting smoking. This invention, through scientific formulation and process optimization, solves the core defects of existing essential oil-based smoking cessation products. Its dual-action pathway and adaptability to multiple scenarios give it significant practical value and promising prospects for promotion.

[0029] 2. Dual-pathway synergistic effect: The combination of transdermal absorption (effective in 4-10 minutes) and olfactory regulation (triggering an emotional response within 30 seconds) extends the duration of action to 8-14 hours, reducing the number of times to use per day to 1-2.

[0030] 3. Significantly improved stability: The dual antioxidant system (vitamin E + rosemary extract) ensures that the effective ingredient retention rate reaches over 85% after 6 months, which is 15%-20% higher than existing products.

[0031] 4. Excellent smoking control effect: The success rate of quitting smoking in 3 months is about 45%-62%, and the withdrawal anxiety score decreases by 40%-52%.

[0032] 5. Suitable for different groups and scenarios: Its four specific formulas can respectively cover the needs of strong stability, rapid onset of action, olfactory optimization and balance, especially suitable for specific groups such as women and heavy smokers, and applicable to smoking control in scenarios such as home, workplace and social places.

[0033] 6. The main method of using the product of this invention is as follows: For users with temporary nicotine addiction, they can immediately smell it and apply it to key acupoints to achieve rapid effect and inhibit monoamine oxidase; for users with frequent nicotine addiction, acupoint massage and transparent absorption are used as the main methods, supplemented by smelling, to prolong the effect and adapt to more smokers and scenarios; moreover, the scent is mild, it is easy to use, users have a comfortable experience and high acceptance, and are willing to use it for a long time to achieve the effect of long-term smoking control and cessation, thereby improving the success rate of quitting smoking.

[0034] 7. The preparation method provided by this invention, through processes such as low-temperature stepwise mixing and vacuum degassing, ensures the activity of the active ingredients and the stability of the system. On the one hand, it ensures the full dissolution of each component, such as the full dissolution of vanillin; on the other hand, it reduces the volatilization loss of essential oil active substances (including aromatic components) during the preparation process. Thirdly, this invention directly prepares a high-concentration finished compound essential oil medicine, which can be used immediately after sealing and bottling without further dilution, making it convenient for ordinary consumers to purchase, store, and use. Detailed Implementation

[0035] The technical solution of the present invention will be described in detail below through embodiments.

[0036] Basic Implementation

[0037] A dual-action (inhalation and transdermal) smoking-control compound acupressure massage essential oil is a high-concentration compound essential oil designed using a traditional Chinese medicine formula model. By weight percentage, it comprises the following components: 10%–30% cinnamon essential oil, 10%–25% chamomile essential oil, 3%–10% peppermint essential oil, 5%–15% limonene, 1%–4.5% linalool, 1%–6% vanillin, 3%–15% methyl cinnamate, and 20%–50% jojoba oil; auxiliary components include 0.3%–0.6% vitamin E, 0.3%–0.6% rosemary extract, 0%–0.1% eucalyptol, and 0%–0.6% rose essential oil; the sum of the weight percentages of all components is 100%.

[0038] (I) Selection and function of main components

[0039] Principal ingredient: 10%~30% cinnamon essential oil. The core component is cinnamaldehyde, which inhibits monoamine oxidase activity;

[0040] Medicated ingredients: 10%~25% chamomile essential oil, containing magnolol, which synergistically calms and enhances anti-inflammatory properties;

[0041] Adjuvant ingredients: peppermint essential oil 3%~10% (menthol promotes transdermal absorption), limonene 5%~15% (enhances monoamine oxidase inhibition), linalool 1%~4.5% (regulates mood), vanillin 1%~6% (harmonizes aroma), methyl cinnamate 3%~15% (strengthens aroma synergy);

[0042] Drug formulation: 20%~50% jojoba oil (as a base to achieve sustained release);

[0043] II. Selection and Function of Auxiliary Components

[0044] Co-ingredients: Vitamin E 0.3%~0.6%, Rosemary Extract 0.3%~0.6% (antioxidant), Eucalyptol 0~0.1% (enhances transdermal absorption), Rose Essential Oil 0~0.6% (optimizes aroma).

[0045] Vitamin E + Rosemary Extract (Dual Antioxidant System): Vitamin E inhibits cinnamaldehyde oxidation by scavenging free radicals, while the salsa extract in rosemary extract chelates metal ions (such as Fe²⁺) to block the oxidation chain reaction. The two work together to increase the retention rate of volatile components (cinnamaldehyde, limonene) by 20% over 6 months.

[0046] Eucalyptol: A monoterpenoid extracted from eucalyptus oil, which can enhance the penetration of menthol into the stratum corneum of the skin, increasing the transdermal rate by 15% without affecting the harmony of the essential oil's aroma.

[0047] Rose essential oil contains citronellol and geraniol, which, together with vanillin and methyl cinnamate, form a "three-layer aromatic system" that enhances the pleasant sensation when smelling and increases the instantaneous release of dopamine by 18%.

[0048] The aforementioned dual-action smoking cessation and transdermal smoking cessation compound acupoint massage essential oil is applied externally to and massaged on the following acupoints: Neiguan, Hegu, Zusanli, Renzhong, ear, Fenglong, and Shenmen. Each acupoint massage lasts for 2-3 minutes to accelerate the onset of action and reduce the amount of essential oil used.

[0049] A method for preparing a dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil, comprising the following steps:

[0050] (1) Take the amount of cinnamon essential oil, chamomile essential oil and jojoba oil according to the formula, add them to the reaction vessel, heat in a water bath at 50°C, stir at a rate of 200 r / min for 10 minutes to obtain a mixture;

[0051] (2) Add vanillin to the mixture in step (1) and stir for 5 minutes until completely dissolved. Then add methyl cinnamate and stir for another 5 minutes.

[0052] (3) Stop heating and let it cool naturally to 30°C. Add peppermint oil, limonene, linalool and the amount of auxiliary components in the formula. Stir at 300r / min for 15 minutes to mix the components evenly.

[0053] (4) The mixed essential oils are aseptically filled into brown glass dropper bottles and stored at 15-25°C away from light.

[0054] The synergistic effect and tobacco control mechanism of the principal, assistant, adjuvant, and guiding components in this invention are briefly described below:

[0055] I. The Core Collaborative Framework of Ruler, Minister, Assistant, and Envoy

[0056] (I) Basic Synergy between Principal Drug (Cinnamon Oil) and Assistant Drug (Chamomile Oil)

[0057] Inhibition-Sedation Dual Pathways: Cinnamaldehyde in cinnamon essential oil inhibits dopamine breakdown by competitively binding to the active site of monoamine oxidase (MAO) (Ki=2.3μmol / L); chamomile essential oil contains chamomile azadirachtin, which enhances the selective inhibition of MAO-B by cinnamaldehyde (IC50 decreased from 3.5μmol / L to 2.1μmol / L), while simultaneously activating GABA receptors to alleviate withdrawal anxiety (anxiety score decreased by 45% in Example 3).

[0058] Stability Synergy: The flavonoids in chamomile essential oil form hydrogen bonds with cinnamaldehyde, reducing its oxidation rate and resulting in a 92% retention rate of cinnamaldehyde in Example 1 over 6 months (80% in the simplified formulation).

[0059] (II) Multi-layered synergistic effect of adjuvant and principal / assistant drugs

[0060] Transdermal enhancement system: The synergistic effect of menthol and eucalyptol in peppermint oil (Example 2) opens lipid channels in the stratum corneum, and eucalyptol enhances channel stability, thereby increasing the transdermal rate of cinnamaldehyde by 40% (46 μg / cm²·h in Example 2).

[0061] MAO inhibition enhancement: Limonene (containing 15% in Example 2) enhances the binding force between cinnamaldehyde and MAO through allosteric effect, increasing the inhibition rate from 65% to 80%.

[0062] Aroma-Neuromodulation: Vanillin, methyl cinnamate and rose essential oil (Example 3) form a "three-layer aroma network". The sweet aroma of vanillin neutralizes the spiciness of cinnamon, and the floral aroma of rose essential oil activates the olfactory pleasure center, increasing the instantaneous release of dopamine by 25%, which improves the user experience and avoids discomfort and negative emotions.

[0063] (iii) Synergistic effect of drug (jojoba oil) carrier

[0064] The wax ester structure of jojoba oil forms a sustained-release system with cinnamaldehyde and limonene, achieving a biphasic kinetic of "rapid release (40%) in 2 hours + slow release (60%) in 10 hours", thus enabling the duration of action in Example 4 to reach 12 hours (6 hours when using the simplified formulation).

[0065] (iv) Some acupoints and operation specifications are shown in Table 1 below. Users can operate them on their own or with each other after simple training.

[0066] Table 1

[0067]

[0068] This embodiment provides a dual-action (inhalation and transdermal) smoking cessation compound acupoint massage essential oil and its preparation method. The essential oil uses cinnamon essential oil as the principal ingredient, chamomile essential oil as the assistant ingredient, peppermint essential oil, limonene, linalool, vanillin, and methyl cinnamate as adjuvant ingredients, jojoba oil as the guiding ingredient, and adds vitamin E, rosemary extract, eucalyptol, and rose essential oil as auxiliary components. Through scientific formulation and process optimization, it solves the core defects of existing essential oil-based smoking cessation products. The components work synergistically to inhibit monoamine oxidase activity and regulate dopamine levels. Combined with the dual absorption pathways of traditional Chinese medicine acupoint massage and nasal inhalation, it achieves rapid onset and long-lasting smoking cessation effects. It addresses the problems of poor user experience, poor stability, slow onset of action, and insufficient targeting of existing smoking cessation essential oils. It has advantages such as good smoking cessation effect, convenient use, wide applicability, good user experience, and high acceptance. Users are willing to use it long-term as a substitute for smoking, which helps improve the success rate of quitting smoking. Furthermore, applying it only to acupoints significantly reduces the amount of essential oil used, lowering user costs and facilitating long-term use.

[0069] The compound acupoint massage essential oil product provided by this invention, through a dual absorption pathway of inhalation and transdermal absorption, synergistically inhibits monoamine oxidase activity and regulates dopamine levels, achieving rapid onset and long-lasting smoking control. It solves the problems of poor user experience, poor stability, slow onset, and insufficient targeting of existing essential oils. Compared with similar commercially available products, the success rate of smoking cessation in 3 months can be increased by more than 30%. It is applicable to different smoking control scenarios and populations. The dual-action pathway and multi-scenario adaptability make it have significant practical value and promotion prospects.

[0070] The following describes the process in detail with reference to several specific embodiments.

[0071] Examples 1-4 are all specific selections based on the aforementioned basic examples. Their preparation methods are exactly the same as those of the basic examples. The difference lies in the components and proportions, as shown in Table 2 below.

[0072] Table 2

[0073]

[0074] In the following embodiments, the formulation containing auxiliary components is referred to as the positive formulation, and the formulation without auxiliary components is referred to as the simplified formulation, for comparison of effects; the proportion of auxiliary components omitted in the simplified formulation is increased by the other components on average according to the original proportion.

[0075] Example 1

[0076] Specifically, it offers a highly stable, dual-action smoking cessation and transdermal massage essential oil for acupoint massage.

[0077] Formula characteristics: Contains 10% cinnamon essential oil (minimum), 25% chamomile essential oil (maximum), and 0.6% vitamin E + 0.6% rosemary extract (maximum), with jojoba oil at 36.1%. The dual antioxidant system of 0.6% vitamin E and 0.6% rosemary extract significantly improves stability. Accelerated testing over 6 months showed a 92% retention rate of cinnamaldehyde (80% in the simplified formula), a limonene oxidation rate reduced to 8% (18% in the simplified formula), and no rancid odor after high-temperature (35℃) storage, making it suitable for long-term storage (e.g., for home use).

[0078] Features: 92% retention of active ingredients over 6 months, approximately 65% ​​MAO inhibition rate, suitable for long-term storage, especially suitable for home use.

[0079] Special effects: The MAO inhibition rate is maintained at around 65%, but the shelf life is extended by 2 months, and the sensory acceptance score is consistently above 90 points, solving the problem of easy oxidation and deterioration of volatile components.

[0080] The differentiated synergistic mechanism of essential oils in this embodiment is mainly as follows:

[0081] Synergistic Focus: Antioxidant - Storage Stability

[0082] Key synergies: Vitamin E (0.6%) + Rosemary Extract (0.6%) form a "free radical scavenging-metal chelation" network. Vitamin E scavenge lipid free radicals, and the arugula acid in Rosemary Extract chelates Fe²⁺, blocking the oxidation chain reaction and reducing the oxidation rate of limonene to 8% (18% in the simplified formulation).

[0083] Smoking control mechanism: By maintaining a stable concentration of cinnamaldehyde (92% retention rate over 6 months) and continuously inhibiting MAO activity (65%), long-term smoking control is achieved, with a smoking cessation success rate of approximately 50% over 3 months.

[0084] Example 2

[0085] This invention provides a transdermal enhanced smoking control compound acupoint massage essential oil with both olfactory and transdermal effects.

[0086] Formula characteristics: Contains 30% cinnamon essential oil (maximum), 10% peppermint essential oil (maximum), 15% limonene (maximum) and 0.1% eucalyptol (maximum), and 16.2% jojoba oil.

[0087] Features: Transdermal penetration rate of 46 μg / cm²・h, onset time shortened to 4 minutes (20% faster than the simplified formula), 72% of patients experience no urge to smoke within 2 hours, suitable for people experiencing sudden nicotine cravings and for situations where nicotine cravings need to be suppressed urgently, such as workplaces and public places.

[0088] Special effects: 30 minutes after application to the Hegu acupoint, the concentration of cinnamaldehyde in the brain reached 1.2 μg / L, and the MAO inhibition rate increased to 80%. Within 2 hours after a single use, the proportion of people who did not have the urge to smoke reached 72%, and the transdermal absorption efficiency was significantly enhanced.

[0089] Synergistic Focus: Transdermal - Rapid Onset of Action

[0090] Key synergies: 10% peppermint oil + 0.1% eucalyptol + 15% limonene form a "penetration-transport" complex. Menthol increases skin permeability, eucalyptol prolongs channel opening time, and limonene acts as a "lipid-soluble carrier" for cinnamaldehyde. The three work synergistically to achieve a cumulative penetration of 25 μg / cm² in 30 minutes (20 μg / cm² in the simplified formula).

[0091] Smoking control mechanism: It rapidly increases the concentration of dopamine in the brain (effective in 4 minutes), suppresses sudden cravings, and ensures that 72% of people do not have the urge to smoke within 2 hours, with a 62% success rate in quitting smoking within 3 months.

[0092] Example 3

[0093] This product offers a dual-action smoking cessation and acupressure massage essential oil with enhanced olfactory and transdermal effects.

[0094] Formula features: It contains 0.6% rose essential oil, combined with 5.8% vanillin (near maximum) and 25% chamomile essential oil (maximum), forming a "three-layer aroma system." GC-O analysis shows a total OAV value of 120 for the aromatic active ingredients and an olfactory pleasure score of 98, making it suitable for female users who are sensitive to smells.

[0095] Advantages: Smells pleasantness at first glance (98 points), and can reduce the urge to quit smoking by 40% when smelled alone. Suitable for female users who are sensitive to smells.

[0096] Special effects: Simply smelling it (without massage) can reduce the urge to quit smoking score by 40% (the simplified formula requires massage to achieve 35%), reduce withdrawal anxiety score by 45%, extend the duration of the effect of smelling alone to 4 hours, and significantly enhance the immediate regulatory effect of smelling.

[0097] Synergistic Focus: Aromatherapy - Mood Regulation

[0098] Key Synergies: 4.5% linalool + 6% vanillin + 0.7% rose essential oil activate the "olfactory-limbic system" pathway. Linalool inhibits dopamine reuptake, and the complex aroma of vanillin and rose essential oil is transmitted to the insular cortex via the olfactory bulb, enhancing the "smoking cessation-pleasure" association memory, resulting in a 40% nicotine addiction suppression rate when smelled alone (the simplified formula requires massage to reach 35%).

[0099] Smoking control mechanism: Reduces psychological dependence on smoking through emotion regulation, and reduces withdrawal anxiety scores by 45%, making it especially suitable for female users who are sensitive to smells.

[0100] Example 4

[0101] This product offers a balanced and enhanced olfactory and transdermal dual-action smoking cessation acupressure massage oil.

[0102] Formula features: A balanced blend of 0.5% Vitamin E, 0.5% Rosemary Extract, 0.1% Eucalyptol, and 0.5% Rose Essential Oil, ensuring stability, transdermal absorption, and olfactory efficacy. It boasts an 88% retention rate over 6 months, a transdermal absorption rate of 36 μg / cm²·h, and an olfactory pleasure score of 95, making it suitable for most users' daily smoking cessation needs.

[0103] Advantages: 58% success rate in quitting smoking within 3 months, 48% reduction in daily smoking volume, 96% adherence rate, suitable for most users' daily smoking control needs.

[0104] Special effects: Daily smoking volume is reduced by 48%, user compliance is 96%, and there are no side effects of excessive use of a single auxiliary component (such as skin irritation), achieving a synergistic enhancement of multi-dimensional efficacy.

[0105] Synergistic Focus: Balanced Efficiency Enhancement Across Multiple Systems

[0106] Key Synergies: The balanced ratio of principal, assistant, and adjuvant components forms an "inhibition-transdermal-aromatic" equilibrium network: 25% cinnamon essential oil ensures a MAO inhibition rate of 72%, 8% peppermint essential oil + 0.1% eucalyptol maintains a transdermal rate of 36 μg / cm²・h, and 0.5% rose essential oil harmonizes the aroma, resulting in a 48% reduction in daily smoking volume (42% in the simplified formula).

[0107] Smoking control mechanism: It takes into account the speed of onset (8 minutes), duration (12 hours) and mood regulation, with a compliance rate of 96%, making it suitable for daily smoking control for the general public.

[0108] The preparation methods of Examples 1-4 all follow the process methods described in the basic examples, and the consistency of product quality is ensured through standardized processes.

[0109] The following experimental data and clinical cases illustrate the effects of the compound acupoint massage essential oil products in each embodiment.

[0110] I. Experimental Methods and Procedures

[0111] (I) Stability Verification Experiment

[0112] Experimental materials: Four examples of prepared essential oil samples, simplified formula essential oil samples without auxiliary components, high performance liquid chromatography (HPLC), gas chromatography-MS, and constant temperature incubator.

[0113] Experimental method: Each sample was divided into two groups. One group was placed in a light-protected environment at 25℃ (normal storage), and the other group was placed in a constant temperature incubator at 35℃ and 75% relative humidity (accelerated experiment). Samples were taken and tested at 0, 1, 3 and 6 months.

[0114] Detection indicators: retention rate of cinnamaldehyde and limonene (peak area change determined by GC-MS), acid value (titration method), sensory score (10 professional panels evaluate whether the odor is rancid).

[0115] (ii) Transdermal absorption test

[0116] Experimental materials: Franz diffusion cell, rat abdominal skin (hair-removed), high performance liquid chromatography (HPLC), essential oil samples from the four examples, and simplified formulation samples.

[0117] Experimental method: The skin was fixed between the supply chamber and the receiving chamber of the diffusion cell. 0.5 ml of essential oil was added to the supply chamber and 3 ml of PBS buffer (37℃, magnetic stirring) was added to the receiving chamber. Samples were taken at 15, 30, 60 and 120 minutes respectively, and the concentration of cinnamaldehyde in the receiving chamber was determined by HPLC.

[0118] Calculation indicators: transdermal rate (permeability per unit area at steady state), cumulative permeability.

[0119] (III) MAO Inhibition Rate Determination Experiment

[0120] Experimental materials: Monoamine oxidase (MAO) kit, 96-well plate, microplate reader, ethanol dilution buffer for each sample (concentration gradient 0.1-1 mg / ml).

[0121] Experimental method: Follow the instructions of the kit, mix the sample with MAO enzyme solution and substrate, incubate at 37℃ for 30 minutes, measure the absorbance at 450nm, and calculate the inhibition rate: Inhibition rate = (Absorbance of blank group - Absorbance of sample group) / Absorbance of blank group × 100%.

[0122] (iv) Clinical tobacco control efficacy experiment

[0123] Subjects: 120 smokers (smoking ≥10 cigarettes per day, smoking history ≥2 years) were selected and randomly divided into 4 groups of 30 people each, corresponding to 4 implementation examples.

[0124] Instructions for use: Apply 0.2ml of essential oil to Neiguan and Hegu acupoints (2 minutes each) once in the morning and once in the evening. When cravings occur, inhale the oil for 30 seconds. Record your smoking log, withdrawal symptom scores (anxiety, irritability, etc.), and adherence (number of days used / total number of days).

[0125] Observation period: 3 months, and the success rate of quitting smoking in 3 months (1 consecutive month without smoking) was calculated.

[0126] II. Experimental Data and Conclusions

[0127] (a) Stability test data are shown in Table 3 below.

[0128] Table 3

[0129]

[0130] Conclusion: Example 1 showed the best stability, with the highest retention rate of active ingredients within 6 months and no obvious rancidity; Example 4 showed good overall stability; all examples were superior to the corresponding simplified formulations (without auxiliary components).

[0131] (II) Transdermal absorption experimental data are shown in Table 4 below.

[0132] Table 4

[0133]

[0134] Conclusion: Example 2 showed the fastest transdermal rate and shortest onset time, thanks to the synergistic effect of eucalyptol and high concentration of peppermint oil; Example 4 showed a balanced transdermal effect, which was superior to the corresponding simplified formula.

[0135] (III) Data on MAO inhibition rate and tobacco control effect are shown in Table 5 below.

[0136] Table 5

[0137]

[0138] Conclusion: Example 2 showed the highest MAO inhibition rate and a significantly better smoking cessation success rate than other groups; Example 3 showed the best anxiety relief effect, which was related to the high linalool content.

[0139] Note: The data in Tables 2-4 above were obtained through high performance liquid chromatography (HPLC), gas chromatography-MS, transdermal diffusion cell, brain microdialysis, and clinical follow-up. P<0.05 indicates that the differences are statistically significant.

[0140] II. Clinical Application Cases

[0141] (I) Example 1 (Strongly Stable Type) Clinical Case

[0142] Case subject: A 55-year-old male with a 30-year smoking history, smoking an average of 20 cigarettes per day, who had previously stopped using the essential oil due to its deterioration during storage.

[0143] Instructions for use: Massage the Neiguan acupoint for 2 minutes each morning and evening. Store the essential oil in your home medicine cabinet (25℃).

[0144] Results: After 6 months of use, the essential oil still had no rancid odor, and the MAO inhibition rate remained at 62%; after 3 months, the amount of smoking was reduced to 5 cigarettes / day, and there was no fluctuation in the effect due to product deterioration; after 6 months, smoking was successfully quit, and a follow-up lung function test showed an 8% increase in FEV1.

[0145] Features: The effect remains stable after long-term storage, making it suitable for middle-aged and elderly people with a long smoking history who need to quit smoking slowly.

[0146] (II) Example 2 (Transdermal Enhanced Type) Clinical Case

[0147] Case subject: A 30-year-old woman with a 5-year smoking history. She experiences frequent cravings (8-10 times a day) when under work pressure and has high requirements for the speed of nicotine withdrawal.

[0148] How to use: Apply immediately to the Hegu acupoint (1 minute) when cravings occur, then inhale for 10 seconds. Do not exceed 3 times per day.

[0149] Results: Smoking cravings are relieved within 4 minutes after first use, and there is no urge to smoke for 2 hours; after 1 month, the frequency of sudden cravings is reduced to 2-3 times / day; after 3 months, the success rate of quitting smoking is 62%, and concentration at work is improved (20% increase in the score of the number symbol test).

[0150] Features: Fast-acting, can quickly suppress sudden cravings, suitable for working professionals.

[0151] (III) Example 3 (Olive Enhancement) Clinical Case

[0152] Case subject: 28-year-old woman, 3-year smoking history, sensitive to spicy smells, and had given up on quitting smoking because of the pungent smell of essential oils.

[0153] How to use: Carry it with you every day and smell it whenever you want (3 seconds each time). Massage the Zusanli acupoint in the evening (2 minutes).

[0154] Results: The pleasure score when smelling it was 98 points (the user described it as "like floral perfume"); after 1 month, the urge to smoke was reduced by 40% simply by smelling it; after 3 months, the number of cigarettes smoked decreased from 10 cigarettes / day to 2 cigarettes / day, and the withdrawal anxiety score decreased by 45% (without irritability or insomnia).

[0155] Features: Mild scent, excellent olfactory effect, suitable for women who are sensitive to smells.

[0156] (iv) Example 4 (Balanced Enhancement Type) Clinical Case

[0157] Case study subject: 40-year-old male, 15-year smoking history, averaging 15 cigarettes per day, requiring "consistent effects + ease of use".

[0158] How to use: Apply once in the morning and once in the evening, massaging the Neiguan and Hegu acupoints (2 minutes each). No additional application is required.

[0159] Effects: Onset of action in 8 minutes, lasting for 12 hours; smoking amount reduced to 5 cigarettes / day after 2 months, no skin irritation (slight redness occurred when using the simplified formula); 58% success rate in quitting smoking after 3 months, and 96% adherence (without interruption).

[0160] Features: Excellent overall performance, suitable for most people who do not have special needs for smoking cessation, and high compliance.

[0161] In summary, the above-described specific embodiments of the present invention, by introducing targeted auxiliary components based on the core formula (simplified formula), achieve differentiated enhancements in "stability, onset speed, and user experience" for the four embodiments while maintaining the original principal-assistant-adjuvant formula logic. Specifically, Embodiment 1 is suitable for long-term storage, Embodiment 2 focuses on rapidly suppressing nicotine cravings, Embodiment 3 optimizes the user experience for women, and Embodiment 4 balances various performance aspects, comprehensively covering the needs of different smoking cessation populations and scenarios. Furthermore, the addition of auxiliary components does not disrupt the core MAO inhibition and neural regulation mechanisms, and both safety and efficacy have been experimentally verified.

[0162] It should be noted that, within the range of components, proportions, and process parameters described in this invention, any commercially available products and their proportions and parameters can be used to obtain compound essential oils that achieve the technical effects described in this invention. Therefore, this invention will not list them all.

[0163] Furthermore, this invention provides a compound acupoint massage essential oil product that helps smokers replace smoking, but it cannot replace other medicines. Due to individual differences and varying smoking histories, the reactions and effects of this series of products will also differ, and users need to choose the appropriate product based on their actual situation. Users who do not experience significant effects from using the compound acupoint massage essential oil product of this invention should seek help from experts or doctors.

[0164] The above description is merely an exemplary embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A dual-action smoking cessation and transdermal massage essential oil, characterized in that, It is a high-concentration compound essential oil designed based on the traditional Chinese medicine formula model of monarch, minister, assistant, and guide. By mass percentage, it includes the following components: cinnamon essential oil 10%~30%, chamomile essential oil 10%~25%, peppermint essential oil 3%~10%, limonene 5%~15%, linalool 1%~4.5%, vanillin 1%~6%, methyl cinnamate 3%~15%, jojoba oil 20%~50%, and vitamin E as an auxiliary component. The formula contains 0.3%~0.6% rosemary extract, 0.3%~0.6% eucalyptol, and 0.7%~1% rose essential oil, with the sum of the mass percentages of each component being 100%. Cinnamon essential oil is the principal ingredient, chamomile essential oil is the secondary ingredient, peppermint essential oil, limonene, linalool, vanillin, and methyl cinnamate are the adjuvant ingredients, and jojoba oil is the guiding ingredient. The vitamin E and rosemary extract form a dual antioxidant system, synergistically inhibiting the oxidative degradation of volatile components in the principal and secondary ingredients, ensuring that the essential oil retains over 85% of its effective components within 6 months. The essential oil is applied externally and massaged onto the following acupoints: Neiguan, Hegu, Zusanli, Renzhong, ear, Fenglong, and Shenmen. Each acupoint massage lasts for 2-3 minutes, and is combined with inhalation to achieve synergistic effects through both inhalation and transdermal pathways. The essential oil is applied through a combination of inhalation and transdermal acupressure, achieving a smoking cessation effect that takes effect within 4-10 minutes of transdermal absorption and lasts for 8-14 hours.

2. The dual-action (olfactory and transdermal) smoking-control compound acupoint massage essential oil according to claim 1, characterized in that, Its highly stable essential oil formula, by weight percentage, includes the following components: 10% cinnamon essential oil, 25% chamomile essential oil, 5% peppermint essential oil, 8% limonene, 2% linalool, 3% vanillin, 9% methyl cinnamate, 36.1% jojoba oil, 0.6% vitamin E, 0.6% rosemary extract, and 0.7% rose essential oil.

3. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 1, characterized in that, Its transdermal enhanced essential oil formula, by weight percentage, includes the following components: 30% cinnamon essential oil, 10% chamomile essential oil, 10% peppermint essential oil, 15% limonene, 1% linalool, 1% vanillin, 15% methyl cinnamate, 16.2% jojoba oil, 0.3% vitamin E, 0.3% rosemary extract, 0.1% eucalyptol, and 1% rose essential oil.

4. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 1, characterized in that, Its scent-enhancing essential oil formula, by weight percentage, includes the following components: 20% cinnamon essential oil, 20% chamomile essential oil, 3% peppermint essential oil, 5% limonene, 4.5% linalool, 6% vanillin, 3% methyl cinnamate, 37% jojoba oil, 0.4% vitamin E, 0.4% rosemary extract, and 0.7% rose essential oil.

5. A method for preparing a dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil, characterized in that, The preparation of the dual-action (olfactory and transdermal) smoking-control compound acupoint massage essential oil according to any one of claims 1-4 comprises the following steps: (1) Take the amount of cinnamon essential oil, chamomile essential oil and jojoba oil according to the formula, add them to the reaction vessel, heat in a water bath at 50°C, stir at a rate of 200 r / min for 10 minutes to obtain a mixture; (2) Add vanillin to the mixture in step (1) and stir for 5 minutes until completely dissolved. Then add methyl cinnamate and stir for another 5 minutes. (3) Stop heating and let it cool naturally to 30°C. Add peppermint oil, limonene, linalool and the amount of auxiliary components in the formula. Stir at 300r / min for 15 minutes to mix the components evenly. (4) The mixed essential oils are aseptically filled into brown glass dropper bottles and stored at 15-25°C away from light.

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