Human body blood pressure simulation system and method based on cardiopulmonary coupling

Abstract

The invention discloses a human body blood pressure simulation system and method based on cardiopulmonary coupling, and belongs to the technical field of physiological parameter simulation equipment. The system comprises a rack, a double-eccentric rotating assembly, an independent motor, a pressure output component and a selectable baseline adjusting mechanism. The two independent motors respectively drive a first rotating component and a second rotating component in the double-eccentric rotating component, so that the first rotating component and the second rotating component are superposed to displace and are transmitted to the water tank through the test panel to drive a water column to lift, thereby forming composite water pressure with heartbeat and breathing characteristics; the base line adjusting mechanism can apply a constant pressure base line on the basis; the pressure output component receives and outputs the composite water pressure. The multi-frequency characteristic of the arterial pressure of the human body can be accurately reproduced, the problem of simulation distortion of a traditional single pressure source is solved, and the method is suitable for fatigue test and performance evaluation of blood pressure testing equipment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of physiological parameter simulation devices, and particularly relates to a human blood pressure simulation system and simulation method based on cardiopulmonary coupling. BACKGROUND

[0002] In the field of medical device performance testing, especially in the fatigue resistance test and performance evaluation of blood pressure test equipment, accurately simulating the dynamic characteristics of human arterial pressure is the key to ensuring the effectiveness of the test.

[0003] In traditional tests, the pressure source used is mostly a static pressure source or a periodic pressure wave of a single frequency, which cannot truly reproduce the complex dynamic characteristics of human arterial pressure. The fluctuation of human arterial pressure is the result of the combined action of the cardiovascular system and the respiratory system, and has significant multi-frequency characteristics: in the cardiovascular system, the heart beat causes high-frequency fluctuations in arterial pressure within each cardiac cycle (frequency about 1-1.5 Hz, corresponding to 60-90 times / minute), forming the difference between systolic pressure and diastolic pressure (pulse pressure, usually 40-50 mmHg), which constitutes the basic form of the pressure waveform; in the respiratory system, the change in thoracic volume affects venous return and cardiac load, causing low-frequency modulation (frequency about 0.2-0.33 Hz, corresponding to 12-20 times / minute) on the basis of the heart beat fluctuation, with a fluctuation amplitude of about 2-10 mmHg (varying with the depth of respiration).

[0004] This "high-frequency heart beat fluctuation superimposed on low-frequency respiratory modulation" composite pressure waveform is medically referred to as cardiopulmonary interaction, so in the performance testing of medical devices, especially pressure-related devices such as blood pressure test equipment, if only a single frequency waveform or a static pressure source is used, it will be difficult to accurately evaluate the response performance of the device under real physiological conditions. SUMMARY

[0005] In view of the deficiencies in the prior art, the present application provides a human blood pressure simulation system and simulation method based on cardiopulmonary coupling.

[0006] The present application discloses a human blood pressure simulation system based on cardiopulmonary coupling, comprising: a rack composed of a test base plate and a test panel that can be raised and lowered above the test base plate, a test water tank being arranged above the test panel; a double eccentric rotating assembly comprising a first rotating member and a second rotating member, the first and second rotating members being arranged in a nested manner in the vertical direction between the test panel and the test base plate; the first rotating member is driven to rotate by a first motor to simulate respiratory pressure fluctuations, and the second rotating member is driven to rotate by a second motor to simulate heart beat pressure fluctuations; The test panel superimposes displacement changes of the first and second rotating members when rotating and drives the test water tank to move up and down to change the water pressure in the test water tank. The pressure output component is connected with the test water tank and is used for receiving and presenting pressure, which is the cardiopulmonary coupling compound water pressure after superimposition of respiratory pressure fluctuation and heartbeat pressure fluctuation.

[0007] As a further improvement of the present application, a baseline adjustment mechanism is further included; the baseline adjustment mechanism includes a lifting module, and the pressure output component moves up and down through the lifting module with the test base plate as the horizontal reference; The lifting module changes the height difference between the pressure output component and the test water tank to generate a baseline adjustment waveform, and the pressure generated by the baseline adjustment waveform is superimposed on the cardiopulmonary coupling compound water pressure.

[0008] As a further improvement of the present application, the first rotating member is rotatably connected with the test panel, the first rotating member is rotatably connected with the second rotating member, and the second rotating member is rotatably connected with the test base plate through a rolling support structure.

[0009] As a further improvement of the present application, the rolling support structure includes a track groove and a ball; The bottom of the test panel is provided with a first rotation matching part corresponding to the first rotating member, and the upper part of the test base plate is provided with a second rotation matching part corresponding to the second rotating member; a plurality of balls are respectively arranged on the outer circumferences of the second rotation matching part and the first rotating member; and a track groove matched with the ball is respectively arranged on the outer circumferences of the first rotation matching part and the second rotating member.

[0010] As a further improvement of the present application, the first rotating member is a first cam, and the second rotating member is a second cam; The eccentricity of the first cam matches the displacement conversion value of the respiratory fluctuation amplitude, and the rotation speed of the first cam matches the respiratory fluctuation frequency; The eccentricity of the second cam matches the displacement conversion value of the heartbeat fluctuation amplitude, and the rotation speed of the second cam matches the heartbeat fluctuation frequency.

[0011] As a further improvement of the present application, the first rotating member is a first regular elliptical eccentric wheel, and the second rotating member is a second regular elliptical eccentric wheel; The difference between the major axis and the minor axis of the first regular elliptical eccentric wheel corresponds to a displacement amount, which matches the displacement conversion value of the respiratory fluctuation amplitude, and the rotation speed of the first regular elliptical eccentric wheel matches the respiratory fluctuation frequency; The displacement amount corresponding to the difference between the long semi-axis and the short semi-axis of the second regular elliptical eccentric wheel matches the displacement conversion value of the heartbeat fluctuation amplitude, and the rotation speed of the second regular elliptical eccentric wheel matches the heartbeat fluctuation frequency.

[0012] As a further improvement of the present application, the test water tank is provided with a grid structure floating on the water surface, which is used to suppress water surface fluctuation, so that the pressure change in the test water tank is smoothly transmitted to the pressure output component.

[0013] As a further improvement of the present application, Z-direction guide shafts are further included; a plurality of Z-direction guide shafts are arranged on the test base plate, and the test panel can move up and down along the Z-direction guide shafts.

[0014] The present application also discloses a human blood pressure simulation method based on cardiopulmonary coupling, which applies the human blood pressure simulation system, and comprises the following steps: The assembly and debugging system is used to fix the test water tank above the test panel, so that the pressure output component is in communication with the test water tank, and the first rotating member and the second rotating member of the double eccentric rotating assembly are nested between the test panel and the test base plate in the vertical direction; The physiological parameters are set, the rotation speed of the first motor is adjusted to match the human respiratory fluctuation frequency, the rotation speed of the second motor is adjusted to match the human heartbeat fluctuation frequency, and the structural parameters of the first rotating member and the second rotating member are set according to the required respiratory fluctuation amplitude and heartbeat fluctuation amplitude; The cardiopulmonary coupling composite water pressure is generated, the first motor and the second motor are started, the first rotating member is driven to rotate to simulate the respiratory pressure fluctuation, the second rotating member is driven to rotate to simulate the heartbeat pressure fluctuation, the displacement change of the test panel is superimposed on the displacement change of the two, and the test water tank is driven to move up and down, so that the cardiopulmonary coupling composite water pressure after superimposition of the respiratory pressure fluctuation and the heartbeat pressure fluctuation is formed in the test water tank; The simulation blood pressure is output, the cardiopulmonary coupling composite water pressure is received by the pressure output component and presented, and the basic simulation of the human blood pressure is completed.

[0015] As a further improvement of the present application, in the process of generating the cardiopulmonary coupling composite water pressure, the following steps are further included: The lifting module of the baseline adjustment mechanism is started at the same time, the lifting module drives the pressure output component to move up and down with the test base plate as a reference, the height difference between the pressure output component and the test water tank is changed to generate a baseline adjustment waveform, the pressure corresponding to the baseline adjustment waveform is superimposed on the cardiopulmonary coupling composite water pressure, and the baseline dynamic change of the human blood pressure is simulated.

[0016] Compared with the prior art, the present application has the following beneficial effects: The present application forms a heart-lung coupling composite water pressure of "high frequency heartbeat fluctuation superimposed low frequency respiratory modulation" in the test water tank through independent driving and displacement superposition design of the double eccentric rotating assembly, perfectly reproduces the multi-frequency characteristics and physiological amplitude of the human arterial pressure, completely breaks through the limitation of the traditional pressure source "simulation distortion, unable to reflect the interaction between heart and lung", ensures the consistency of the simulated pressure and the real blood pressure, and solves the technical pain point that the traditional static / single frequency pressure source cannot reproduce the complex dynamic characteristics of the human arterial pressure.

[0017] The present application adds a baseline adjustment mechanism, changes the height difference between the pressure output component and the test water tank by using the lifting module, generates an adjustable baseline adjustment waveform, realizes the simulation of blood pressure baseline dynamic drift, can cover the simulation scene of "full physiological cycle blood pressure characteristics", and can also output stable signals for a long time, providing real working conditions for fatigue resistance test and performance evaluation of blood pressure test equipment, and avoiding test misjudgment caused by simulation signal distortion. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 The structure of the blood pressure simulation system based on heart-lung coupling disclosed in an embodiment of the present application is a front view schematic diagram; Figure 2 The structure of the blood pressure simulation system based on heart-lung coupling disclosed in an embodiment of the present application is a side view schematic diagram; Figure 3 The waveform diagram of the heart-lung coupling composite pressure of the blood pressure simulation system based on heart-lung coupling disclosed in an embodiment of the present application.

[0019] In the figure: 1, rack; 1-1, test bottom plate; 1-2, test panel; 1-3, Z-direction guide shaft; 2, double eccentric rotating assembly; 2-1, first rotating member; 2-2, second rotating member; 3, test water tank; 4, pressure output component; 5, first motor; 6, second motor; 7, connecting pipe; 8, lifting module; 9, first rotating matching part; 10, second rotating matching part; 11, ball; 12, track groove. DETAILED DESCRIPTION

[0020] To make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0021] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0022] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0023] The present application will be described in further detail below in conjunction with the drawings: As Figures 1-2 shown, according to the human blood pressure simulation system based on cardiopulmonary coupling provided by the present application, comprising a rack 1, a double eccentric rotating assembly 2, a pressure output component 4, wherein the rack 1 is composed of a test base plate 1-1 and a test panel 1-2 which can be lifted up and down above the test base plate 1-1, a test water tank 3 is arranged above the test panel 1-2; the double eccentric rotating assembly 2 comprises a first rotating member 2-1 and a second rotating member 2-2, the first rotating member 2-1 and the second rotating member 2-2 are sequentially nested between the test panel 1-2 and the test base plate 1-1 in the vertical direction, and are designed as non-coaxial; the first rotating member 2-1 is driven to rotate by a first motor 5 to simulate respiratory pressure fluctuation, and the second rotating member 2-2 is driven to rotate by a second motor 6 to simulate heartbeat pressure fluctuation; that is, the first rotating member 2-1 and the second rotating member 2-2 constitute a non-coaxial double rotating member bionic structure for simulating two independent but coupled physiological driving sources of heart beat and respiratory modulation. The test panel 1-2 superimposes the displacement change of the first rotating member 2-1 and the second rotating member 2-2 when rotating and drives the test water tank 3 to move up and down to change the water pressure in the test water tank 3; the pressure output component 4 is connected with the test water tank 3 through a connecting pipe 7, and the pressure output component 4 is used for receiving and presenting pressure, which is the cardiopulmonary coupling composite water pressure after superimposing the respiratory pressure fluctuation and the heartbeat pressure fluctuation.

[0024] Specifically: As Figures 1-2As shown, in the above embodiment, preferably, a baseline adjustment mechanism is also included; the baseline adjustment mechanism includes a lifting module 8, and the pressure output component 4 moves up and down with the test base plate 1-1 as a horizontal reference via the lifting module 8; in this embodiment, the range of vertical movement is ±60 cm. The lifting module 8 generates a baseline adjustment waveform by changing the height difference between the pressure output component 4 and the test water tank 3, so that the pressure generated by the baseline adjustment waveform is superimposed on the cardiopulmonary coupling composite water pressure. The height of the test base plate 1-1 from the ground is 70 cm.

[0025] In the above embodiment, preferably, the lifting module 8 includes a linear motor, and the pressure output component 4 is mounted on a slider connected to the linear motor. The pressure output component 4 moves up and down through the linear motor to adjust the blood pressure baseline value.

[0026] like Figure 2 As shown, in the above embodiment, preferably, the first rotating component 2-1 and the test panel 1-2, the first rotating component 2-1 and the second rotating component 2-2, and the second rotating component 2-2 and the test base plate 1-1 are all rotatably connected by a rolling support structure. In this embodiment, the rolling support structure includes a track groove 12 and balls 11; a first rotating mating part 9 is provided at the bottom of the test panel 1-2 corresponding to the first rotating component 2-1, and a second rotating mating part 10 is provided at the top of the test base plate 1-1 corresponding to the second rotating component 2-2; a plurality of balls 11 are respectively provided on the outer circumference of the second rotating mating part 10 and the first rotating component 2-1; track grooves 12 that mate with the balls 11 are respectively provided on the outer circumference of the first rotating mating part 9 and the second rotating component 2-2. This simplifies the structure and reduces the cost, while ensuring the smoothness of the movement and achieving low-friction smooth sliding of the first rotating component 2-1 and the second rotating component 2-2.

[0027] In the above embodiments, preferably, the test water tank 3 is equipped with a grid structure floating on the water surface. The grid structure is used to suppress water surface fluctuations so that pressure changes within the test water tank 3 are smoothly transmitted to the pressure output component 4. In this embodiment, the pressure output component 4 can be an artificial blood vessel.

[0028] In the above embodiments, preferably, it also includes Z-direction guide shafts 1-3; a plurality of Z-direction guide shafts 1-3 are arranged on the test base plate 1-1, and the test panel 1-2 can move up and down along the Z-direction guide shafts 1-3.

[0029] In the above embodiment, preferably, the first rotating member 2-1 is a first regular elliptical eccentric wheel, and the second rotating member 2-2 is a second regular elliptical eccentric wheel; the difference between the major axis and the minor axis of the first regular elliptical eccentric wheel corresponds to a displacement amount matched with a displacement conversion value of a respiratory fluctuation amplitude, and the rotation speed of the first regular elliptical eccentric wheel is matched with a respiratory fluctuation frequency; the difference between the major axis and the minor axis of the second regular elliptical eccentric wheel corresponds to a displacement amount matched with a displacement conversion value of a heartbeat fluctuation amplitude, and the rotation speed of the second regular elliptical eccentric wheel is matched with a heartbeat fluctuation frequency. In this embodiment, the heartbeat fluctuation frequency ranges from 1 to 1.5 Hz, and the heartbeat fluctuation amplitude ranges from 40 to 50 mmHg; the respiratory fluctuation frequency ranges from 0.2 to 0.33 Hz, and the respiratory fluctuation amplitude ranges from 2 to 10 mmHg.

[0030] In another embodiment, preferably, the first rotating member 2-1 is a first cam, and the second rotating member 2-2 is a second cam; the eccentricity of the first cam is matched with a displacement conversion value of a respiratory fluctuation amplitude, and the rotation speed of the first cam is matched with a respiratory fluctuation frequency; the eccentricity of the second cam is matched with a displacement conversion value of a heartbeat fluctuation amplitude, and the rotation speed of the second cam is matched with a heartbeat fluctuation frequency.

[0031] In the above embodiment, preferably, the rotation frequencies of the first rotating member 2-1 and the second rotating member 2-2 can be adjusted according to the respiratory fluctuation frequency and the heartbeat fluctuation frequency, respectively, to adapt to the heartbeat and respiration simulation requirements under different physiological states.

[0032] The application further discloses a human blood pressure simulation method based on heart-lung coupling, which is applied to the human blood pressure simulation system and comprises the following steps of: Based on the heart-lung interaction mechanism, the arterial pressure waveform is decomposed into a high-frequency heartbeat fluctuation component and a low-frequency respiratory fluctuation component; the high-frequency heartbeat fluctuation component comprises a heartbeat fluctuation frequency and a heartbeat fluctuation amplitude, and the low-frequency respiratory fluctuation component comprises a respiratory fluctuation frequency and a respiratory fluctuation amplitude. The system is assembled and debugged, the test water tank 3 is fixed above the test panel 1-2, the pressure output component 4 is communicated with the test water tank 3, and the first rotating member 2-1 and the second rotating member 2-2 of the double-eccentric rotating assembly 2 are non-coaxially nested between the test panel 1-2 and the test bottom plate 1-1 in the vertical direction. The physiological parameters are set, the rotation speed of the first motor 5 is adjusted to match the respiratory fluctuation frequency of the human body, the rotation speed of the second motor 6 is adjusted to match the heartbeat fluctuation frequency of the human body, and the structure parameters of the first rotating member 2-1 and the second rotating member 2-2 are set according to the respiratory fluctuation amplitude and the heartbeat fluctuation amplitude requirements. Generate a cardiopulmonary coupled composite water pressure, start the first motor 5 and the second motor 6, drive the first rotating component 2-1 to rotate to simulate respiratory pressure fluctuations and the second rotating component 2-2 to rotate to simulate heartbeat pressure fluctuations. The displacement changes of the two components are superimposed on the test panel 1-2 and drive the test water tank 3 to rise and fall, so that a cardiopulmonary coupled composite water pressure is formed in the test water tank 3 after the respiratory pressure fluctuations and heartbeat pressure fluctuations are superimposed. The simulated blood pressure is output, and the pressure output component 4 receives and presents the cardiopulmonary coupled composite water pressure to complete the basic simulation of human blood pressure.

[0033] In the above embodiments, preferably, the process of generating cardiopulmonary coupled hydrostatic pressure further includes: Simultaneously, the lifting module 8 of the baseline adjustment mechanism is activated, and the lifting module 8 is controlled to drive the pressure output component 4 to move up and down with the test base plate 1-1 as the reference, changing the height difference between the pressure output component 4 and the test water tank 3 to generate a baseline adjustment waveform, so that the pressure corresponding to the baseline adjustment waveform is superimposed on the cardiopulmonary coupling composite water pressure to simulate the baseline dynamic change of human blood pressure. Example 1

[0034] In this embodiment, the liquid level in the test tank 3 is 50 cm, the distance between the test base plate 1-1 and the ground is 70 cm, and the pressure output component 4 (artificial blood vessel) moves up and down (±60 cm) with the test base plate 1-1 as the horizontal reference via a linear motor; the pressure output component 4 is initially at the same horizontal plane as the test base plate 1-1.

[0035] In this embodiment, the double-eccentric rotating component 2 uses a first regular elliptical eccentric wheel and a second regular elliptical eccentric wheel. The first regular elliptical eccentric wheel is driven by a first motor 5 to simulate respiratory pressure fluctuations, and the second regular elliptical eccentric wheel is driven by a second motor 6 to simulate cardiac pressure fluctuations. In this embodiment, the rotational speed of the first motor 5 is set to the respiratory frequency of 0.25Hz, and the rotational speed of the second motor 6 is set to the cardiac frequency of 1.2Hz, so as to finally synthesize a periodic blood pressure waveform.

[0036] In this embodiment, the structural design process of the first regular elliptical eccentric wheel and the second regular elliptical eccentric wheel is as follows: Based on the proportion of the influence of respiration and heartbeat on human blood pressure, the proportion of the influence of heartbeat on human blood pressure is set at 95%, and the proportion of the influence of respiration on human blood pressure is set at 5%. Based on human blood pressure, set target blood pressure parameters: systolic / diastolic pressure: 120 / 90 mmHg, pulse pressure: PP = difference between systolic and diastolic pressure = 30 mmHg; Calculate the amplitude A of heartbeat fluctuations based on pulse pressure. heart Displacement transformation value △H heart (Using sine as the notation, taking the half-peak value), where Aheart = PP / 2 = 15 mmHg, AH heart = 15 * 13.6 = 204 mm (static water pressure conversion relationship is 1 mmHg ≈ 13.6 mm water column); Based on the proportion of the influence of breathing and heartbeat on human blood pressure, the displacement conversion value AH of the amplitude A of the breathing wave is calculated resp resp， Wherein, A resp ≈ 0.789 mmHg, AH resp = 0.789 * 13.6 ≈ 10.7 mm; Based on the mechanical transmission relationship when the rotation of the first and second regular elliptical eccentric wheels is converted into the up and down displacement of the test panel 1-2, the mechanical transmission gain coefficient λ = 3 is set in the embodiment (the coefficient can be adjusted according to the actual transmission structure such as the length ratio of the rocker arm, the angle of the wedge mechanism, etc.). According to the corresponding relationship between the displacement conversion value and the eccentricity of the elliptical eccentric wheel, the eccentricity e of the elliptical eccentric wheel needs to meet e = AH / λ, so as to ensure that it can accurately output the required displacement through the transmission structure when rotating; For the first regular elliptical eccentric wheel: its eccentricity e resp = AH resp / λ = 10.7 mm / 3 ≈ 3.6 mm. Similarly, when the geometric transmission coefficient κ = 1, the difference between the major axis and the minor axis of the first regular elliptical eccentric wheel: a-b = 2e resp / κ = 2 × 3.6 mm / 1 = 7.2 mm. Considering the nesting installation relationship with the second regular elliptical eccentric wheel, the minor axis b resp of the first regular elliptical eccentric wheel is set to 20 mm, and the major axis a resp = b resp + 7.2 mm = 27.2 mm; For the second regular elliptical eccentric wheel: its eccentricity e heart = AH heart / λ = 204 mm / 3 = 68 mm. Since the difference between the major axis and the minor axis of the regular elliptical eccentric wheel needs to match the displacement output requirement corresponding to the eccentricity, when the driven part is ideal rolling contact (geometric transmission coefficient κ = 1), the difference between the major axis a and the minor axis b satisfies a-b = 2e heart / κ. Substituting the numerical value can obtain a-b = 2 × 68 mm / 1 = 136 mm. Considering the equipment installation space and structural strength requirement, the minor axis b heart of the second regular elliptical eccentric wheel is set to 50 mm, and the major axis a heart = b heart + 136 mm = 186 mm.

[0037] ​In this embodiment, the first regular elliptical eccentric wheel and the second regular elliptical eccentric wheel are driven to rotate by the first motor 5 and the second motor 6, respectively. The displacement of the two regular elliptical eccentric wheels during rotation is superimposed on the test panel 1-2, which drives the test water tank 3 to move up and down, causing the water column (liquid level) to rise and fall, thereby changing the height difference between the liquid level in the test water tank 3 and the pressure output component 4. At this time, the water pressure in the test water tank 3 changes and is transmitted to the pressure output component 4 through the connecting pipe 7. The pressure output component 4 presents the pressure change, and the pressure change of the pressure output component 4 can be detected by a blood pressure gauge or a pressure detection machine, and a cardiopulmonary coupling pressure waveform change over time can be generated.

[0038] In this embodiment, the pressure output component 4 reciprocates up and down via a linear motor to change the height difference between the pressure output component 4 and the liquid level in the test water tank 3, thereby generating a baseline adjustment waveform. The pressure generated by the baseline adjustment waveform is then superimposed on the cardiopulmonary coupling composite water pressure. That is, the pressure ultimately detected by the blood pressure gauge or pressure detection machine is: P(t) = y_respiration(t) + y_heartbeat(t) + y_baseline conditioning(t); In the formula, y_breathing(t) is the simulated pressure generated by the first regular elliptical eccentric wheel at a certain time t; y_heartbeat(t) is the simulated pressure generated by the second regular elliptical eccentric wheel at a certain time t; and y_baseline adjustment(t) is the baseline adjustment generated by the linear motor at a certain time t.

[0039] By combining the final pressure at multiple moments, a periodic pressure waveform that varies over time can be obtained. This periodic pressure waveform can simulate the characteristics of blood pressure changes in the human body under normal, exercise, or pathological conditions.

[0040] like Figure 3 As shown, in this embodiment, without enabling baseline pressure regulation, the respiratory rate is set to 0.25Hz and the heart rate to 1.2Hz. Driven by the rotation of the first and second regular elliptical eccentric wheels, the composite pressure waveform output by the pressure output component 4 clearly demonstrates the superposition effect of high-frequency heartbeat fluctuations and low-frequency respiratory modulation within a 24-second range. This waveform intuitively proves that the superposition design of the dual eccentric rotating component 2 can realistically reproduce the cardiopulmonary coupling characteristics of human blood pressure. Compared with the single fluctuation output by the traditional single eccentric wheel, the composite waveform of this invention is closer to the real arterial pressure change pattern.

[0041] The advantages of this invention are: The present application forms a heart-lung coupling composite water pressure of "high frequency heartbeat fluctuation superimposed low frequency respiratory modulation" in the test water tank 3 through independent driving and displacement superposition design of the double eccentric rotating assembly 2, perfectly reproduces the multi-frequency characteristics and physiological amplitude of human arterial pressure, completely breaks through the limitation of traditional pressure source "simulation distortion, unable to reflect the interaction between heart and lung", ensures the consistency of simulated pressure and real blood pressure, and solves the technical pain point that the traditional static / single frequency pressure source cannot reproduce the complex dynamic characteristics of human arterial pressure.

[0042] The present application generates adjustable baseline adjustment waveform by changing the height difference between the pressure output component 4 and the test water tank 3 by means of the lifting module 8, realizes the simulation of blood pressure baseline dynamic drift, can cover the simulation scene of "full physiological cycle blood pressure characteristics", and can also output stable signals for a long time, provides real working conditions for fatigue resistance test and performance evaluation of blood pressure test equipment, and avoids test misjudgment caused by simulation signal distortion.

[0043] The above is only the preferred embodiment of the present application and is not used to limit the present application. For those skilled in the art, the present application can have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A human blood pressure simulation system based on cardiopulmonary coupling, characterized by, The utility model relates to a test device for simulating cardiopulmonary coupling complex water pressure, comprising: a rack composed of a test base plate and a test panel capable of being lifted up and down above the test base plate, wherein a test water tank is arranged above the test panel; a double eccentric rotating assembly comprising a first rotating member and a second rotating member, which are sequentially nested between the test panel and the test base plate in the vertical direction; the first rotating member is driven to rotate by a first motor to simulate respiratory pressure fluctuation, and the second rotating member is driven to rotate by a second motor to simulate heartbeat pressure fluctuation; the test panel superimposes displacement changes of the first and second rotating members when rotating and drives the test water tank to move up and down to change water pressure in the test water tank; a pressure output component connected with the test water tank for receiving and presenting pressure, which is cardiopulmonary coupling complex water pressure obtained by superimposing respiratory pressure fluctuation and heartbeat pressure fluctuation.

2. The human blood pressure simulation system of claim 1, wherein, It also comprises a baseline adjustment mechanism; the baseline adjustment mechanism comprises a lifting module, and the pressure output component moves up and down by the lifting module with the test base plate as the horizontal reference; the lifting module generates baseline adjustment waveform by changing the height difference between the pressure output component and the test water tank, and the pressure generated by the baseline adjustment waveform is superimposed on the cardiopulmonary coupling complex water pressure.

3. The human blood pressure simulation system of claim 1, wherein, The first rotating member, the test panel, the first rotating member and the second rotating member, and the second rotating member and the test base plate are rotationally connected by rolling support structures.

4. The human blood pressure simulation system of claim 3, wherein, The rolling support structure comprises a track groove and a ball; the bottom of the test panel is provided with a first rotating fitting part corresponding to the first rotating member, and the upper part of the test base plate is provided with a second rotating fitting part corresponding to the second rotating member; a plurality of balls are arranged on the outer circumferences of the second rotating fitting part and the first rotating member, respectively; and the first rotating fitting part and the outer circumference of the second rotating member are respectively provided with track grooves matched with the balls.

5. The human blood pressure simulation system of claim 1, wherein, The first rotating member is a first cam, and the second rotating member is a second cam; the eccentricity of the first cam matches the displacement conversion value of the respiratory fluctuation amplitude, and the rotating speed of the first cam matches the respiratory fluctuation frequency; the eccentricity of the second cam matches the displacement conversion value of the heartbeat fluctuation amplitude, and the rotating speed of the second cam matches the heartbeat fluctuation frequency.

6. The human blood pressure simulation system of claim 1, wherein, The first rotating member is a first regular elliptical eccentric wheel, and the second rotating member is a second regular elliptical eccentric wheel; the difference between the major axis and the minor axis of the first regular elliptical eccentric wheel corresponds to a displacement amount matched with the displacement conversion value of the respiratory fluctuation amplitude, and the rotating speed of the first regular elliptical eccentric wheel matches the respiratory fluctuation frequency; the difference between the major axis and the minor axis of the second regular elliptical eccentric wheel corresponds to a displacement amount matched with the displacement conversion value of the heartbeat fluctuation amplitude, and the rotating speed of the second regular elliptical eccentric wheel matches the heartbeat fluctuation frequency.

7. The human blood pressure simulation system of claim 1, wherein, The test water tank is provided with a grid structure floating on the water surface, which is used to suppress water surface fluctuation to stably transmit pressure changes in the test water tank to the pressure output component.

8. The human blood pressure simulation system of claim 1, wherein, Also included are Z-direction guide shafts; a plurality of the Z-direction guide shafts are arranged on the test base plate, and the test panel is movable up and down along the Z-direction guide shafts.

9. A method for simulating blood pressure of a human body based on cardiopulmonary coupling, applied to the system for simulating blood pressure of a human body according to any one of claims 1-7, characterized in that, Comprise: The assembly and debugging system fixes the test water tank above the test panel, communicates the pressure output component with the test water tank, and ensures that the first rotating member and the second rotating member of the double eccentric rotating assembly are nested between the test panel and the test base plate in the vertical direction; Set physiological parameters, adjust the rotation speed of the first motor to match the respiratory fluctuation frequency of the human body, adjust the rotation speed of the second motor to match the heartbeat fluctuation frequency of the human body, and set the structural parameters of the first rotating member and the second rotating member according to the target simulated human physiological characteristics, respiratory fluctuation amplitude, and heartbeat fluctuation amplitude requirements; Generate heart-lung coupling composite water pressure, start the first motor and the second motor, drive the first rotating member to rotate to simulate respiratory pressure fluctuation, and drive the second rotating member to rotate to simulate heartbeat pressure fluctuation, the test panel superimposes the displacement changes of the two and drives the test water tank to move up and down, so that the test water tank forms heart-lung coupling composite water pressure after superimposing respiratory pressure fluctuation and heartbeat pressure fluctuation; Output simulated blood pressure, receive and present the heart-lung coupling composite water pressure through the pressure output component, and complete the basic simulation of human blood pressure.

10. The method of claim 9, wherein the method further comprises: In the process of generating heart-lung coupling composite water pressure, also includes: Simultaneously start the lifting module of the baseline adjustment mechanism, control the lifting module to drive the pressure output component to move up and down with the test base plate as the reference, change the height difference between the pressure output component and the test water tank to generate a baseline adjustment waveform, superimpose the pressure corresponding to the baseline adjustment waveform on the heart-lung coupling composite water pressure, and simulate the baseline dynamic change of human blood pressure.

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