A rapid abdominal wound hemostasis device

Abstract

The application discloses a kind of abdominal trauma rapid hemostasis device, it is related to medical instrument technical field, and its technical solution main points are: including sleeve and medicine storage cavity, sleeve top is connected with push disc, sleeve bottom is equipped with extrusion disc, sleeve bottom is equipped with first connecting pipe and second connecting pipe, which are through extrusion disc and sleeve, inside sleeve is equipped with supplementary medicine storage cavity, first connecting pipe is equipped with first suspension, and first suspension is connected with first connecting line, and the other end of first connecting line is connected with first suspension ball, second connecting pipe is equipped with second suspension, and second suspension is connected with second connecting line, and the other end of second connecting line is connected with second suspension ball;Flexible skin surface of horn shape is fixedly connected around medicine storage cavity bottom, medicine storage cavity bottom is connected with medicine outlet hose, and medicine outlet hose is connected with medicine outlet port.The device can control the amount of medicine sprayed each time to be basically same, with the ability of continuous spraying medicine for hemostasis.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a device for rapid hemostasis of abdominal trauma. Background Technology

[0002] Excessive blood loss is one of the leading causes of death during accidents and surgical procedures. Therefore, rapid hemostasis is an urgent requirement for the treatment and rescue of injured and sick individuals. Whether it's dangerous activities like mountaineering and exploration in the wild or accidents like car crashes and explosions in the city, abdominal trauma is very common. Abdominal tissues are fragile, and vital organs are located within the abdominal cavity. Once the abdomen is injured, it can lead to massive bleeding, threatening the lives of those involved. Currently, most common abdominal trauma hemostasis devices achieve hemostasis through compression. However, in actual use, compression usually only stops bleeding in veins and arteries. When organs are damaged and bleeding occurs, compression not only fails to stop the bleeding but may even cause secondary damage to the organs.

[0003] Existing technologies already exist for achieving rapid hemostasis of internal abdominal organs by spraying hemostatic drugs or materials into the abdominal cavity through the wound. Chinese invention patent CN110051926A discloses a hemostatic device suitable for abdominal organ trauma, comprising a cylindrical body, one end of which is connected to a conical shell. A rubber pad is provided at the edge of the conical shell, and tin foil is connected to the outer wall of the rubber pad. Inside the cylindrical body, inside a hemostatic pill, a rubber stopper is installed. A foam pad is provided on the outer wall of the rubber stopper near the hemostatic pill, and a fixing frame is connected to the rear wall of the rubber stopper. A push plate is connected to the inner wall of the fixing frame.

[0004] However, it still has the following problems:

[0005] 1. The amount of drug sprayed each time is random and uncontrollable, relying on the instantaneous force when the spring returns to its original position to achieve drug spraying.

[0006] 2. If the medication cannot be replenished, it will become increasingly difficult to spray the remaining medication after the first application. If the injury is severe, the ability to stop the bleeding with subsequent applications of medication will be poor if the first application fails to stop the bleeding. Summary of the Invention

[0007] The purpose of this invention is to provide a rapid hemostasis device for abdominal trauma, which can control the amount of medicine sprayed each time to be basically the same and has the ability to continuously spray medicine for hemostasis.

[0008] The above-mentioned technical objective of the present invention is achieved through the following technical solution: a rapid hemostasis device for abdominal trauma, comprising a cannula and a drug storage chamber, wherein a push plate is connected to the top of the cannula, a squeeze plate is provided at the bottom of the cannula, a first connecting pipe and a second connecting pipe are provided at the bottom of the cannula penetrating the squeeze plate and the cannula, a supplementary drug storage chamber is provided inside the cannula, a first suspension point is provided inside the first connecting pipe, a first connecting line is connected to the first suspension point, and a first suspension ball is connected to the other end of the first connecting line, a second suspension point is provided inside the second connecting pipe, a second connecting line is connected to the second suspension point, and a second suspension ball is connected to the other end of the second connecting line; a trumpet-shaped flexible skin-contact surface is fixedly connected around the bottom of the drug storage chamber, a drug dispensing hose is connected to the bottom of the drug storage chamber, and a drug dispensing port is connected to the drug dispensing hose.

[0009] The present invention is further configured such that: the drug storage cavity is provided with a first chamber and a second chamber, and the drug replenishment cavity is divided into a first replenishment chamber and a second replenishment chamber.

[0010] The present invention is further configured such that: one end of the first connecting tube is connected to the first supplementary chamber, and the other end is connected to the first chamber; one end of the second connecting tube is connected to the second supplementary chamber, and the other end is connected to the second chamber.

[0011] The present invention is further configured such that the dispensing tubing is simultaneously connected to the first chamber and the second chamber.

[0012] By adopting the above technical solution, during use, the dispensing tubing and dispensing port are inserted into the abdominal cavity. Pushing the pusher plate activates the compression plate connected to it, compressing the silicone-made drug storage chamber. The drug is then transported through the dispensing tubing and sprayed into the abdominal cavity through the dispensing port for hemostasis. After the drug is sprayed into the abdominal cavity under compression, the storage chamber is under negative pressure. During the rebound process, the drug in the replenishment storage chamber is drawn in through the connecting tube to replenish the drug in the storage chamber. When the drug height causes the first and second suspended balls to rise into the first and second hemispherical openings respectively, the drug stops flowing out, thus controlling the amount of drug in the storage chamber. This allows for control over the amount of drug sprayed each time. Two chambers are provided in both the storage chamber and the replenishment storage chamber because the sprayed PEG gel is usually a two-component compound; to avoid premature cross-linking and device blockage before use, it needs to be stored separately.

[0013] The present invention is further configured such that the flexible skin-adhesive surface is made of medical adhesive tape.

[0014] By adopting the above technical solution, the flexible skin-adhesive surface is adhered to the abdominal wall to provide fixation, thereby facilitating continuous drug delivery.

[0015] The present invention is further configured such that the drug storage cavity is made of silicone material.

[0016] By adopting the above technical solution, silicone possesses a certain elastic deformation capability. After being squeezed by the extrusion disc and sprayed into the abdominal cavity, it can rebound on its own. Because the drug storage cavity is under negative pressure after being squeezed and sprayed into the abdominal cavity, it will draw in and replenish the drug storage cavity through the connecting tube during the rebound process, so as to replenish the drug storage cavity.

[0017] The present invention is further configured such that: the bottom of the first connecting pipe is provided with a first hemispherical opening, and the bottom of the second connecting pipe is provided with a second hemispherical opening.

[0018] By adopting the above technical solution, the hemispherical opening allows the suspended ball to float to the bottom of the connecting tube more easily, and the large opening at the bottom of the connecting tube effectively prevents drug backflow.

[0019] The present invention is further configured such that: the top of the supplementary drug storage chamber is provided with an air vent, the opening of the air vent is provided with tin foil, and the air vent is connected to the first supplementary chamber and the second supplementary chamber.

[0020] The present invention is further configured such that the push plate and the sleeve are detachably connected by threads or snaps.

[0021] By adopting the above technical solution, after opening the push plate, tearing open the tin foil at the air port or punching air holes can effectively maintain the air pressure balance in the supplementary drug storage chamber, prevent the drug from being drawn back from the storage chamber into the supplementary drug storage chamber, and if the amount of drug is insufficient, it can be replenished again from this point into the supplementary drug storage chamber.

[0022] The present invention further provides a drug loaded in the above-described device, comprising a PEG hydrogel and a thrombin lyophilized powder, wherein the mass ratio of the PEG hydrogel to the thrombin lyophilized powder is 10-20:1.

[0023] By employing the above-mentioned technical solution, PEG gel can rapidly gel upon contact with blood or body fluids through a physicochemical reaction, forming a solid barrier. Its gel network structure can quickly absorb water from the blood, concentrate platelets, thrombin, and fibrinogen, accelerate thrombus formation, and promote coagulation. The lyophilized thrombin powder mixed in can directly promote the conversion of fibrinogen into fibrin, forming a blood clot. The combined use of these two components further enhances coagulation function. Furthermore, since both PEG gel and lyophilized thrombin powder are drugs that can be absorbed by the patient's body, it avoids the need for manual removal of residual drugs later. Finally, because the hemostatic effect of the combined use is superior to that of using PEG gel alone, a smaller dosage is required for the same blood volume. Although PEG gel can be absorbed, absorption takes time, and patients are prone to rejection reactions during the incomplete absorption process. Therefore, using a smaller dosage is more beneficial for the patient's later recovery.

[0024] In summary, this invention has the following beneficial effects: During use, the dispensing tubing and outlet are inserted into the abdominal cavity. Pushing the pusher plate activates the compression plate connected to it, compressing the silicone-made drug storage chamber. The drug is then transported through the dispensing tubing and sprayed into the abdominal cavity through the outlet for hemostasis. After the drug is sprayed into the abdominal cavity under pressure, the storage chamber experiences a negative pressure state. During the rebound process, the connecting tube draws in the replenishing drug storage chamber to replenish the existing drug. When the drug level causes the first and second suspended balls to rise into the first and second hemispherical openings respectively, the drug stops flowing out, thus controlling the amount of drug in the storage chamber. This allows for control over the amount of drug sprayed each time. Two chambers are provided in both the storage chamber and the replenishing drug storage chamber because the sprayed PEG gel is typically a two-component compound. Before use, to avoid premature cross-linking and device blockage, they need to be stored separately. Therefore, the device provided in this invention, with its flexible skin-adhesive surface, can achieve continuous local hemostatic drug spraying. In actual abdominal trauma hemostasis procedures, systemic administration of coagulants is often unsuitable. This device can effectively achieve local hemostasis and provide continuous local drug delivery for hemostasis.

[0025] Upon contact with blood or body fluids, PEG gel rapidly gels through a physicochemical reaction, forming a solid barrier. Its gel network structure quickly absorbs water from the blood, concentrating platelets, thrombin, and fibrinogen, accelerating thrombus formation and promoting coagulation. The lyophilized thrombin powder mixed in directly promotes the conversion of fibrinogen into fibrin, forming a blood clot. The combined use of these two components further enhances coagulation function. Furthermore, since both PEG gel and lyophilized thrombin powder are drugs that can be absorbed by the patient's body, manual removal of residual drugs is unnecessary. Finally, because the hemostatic effect of the combination is superior to that of PEG gel alone, a smaller dosage is required for the same blood volume. Although PEG gel is self-absorbable, absorption takes time, and patients are prone to rejection reactions during this period. Therefore, using a smaller dosage is more beneficial for the patient's later recovery. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the overall structure of the device in Embodiment 1 of the present invention;

[0027] Figure 2 This is a schematic diagram showing the connection between the sleeve, the first connecting pipe, and the second connecting pipe in Embodiment 1 of the present invention;

[0028] Figure 3 This is a cross-sectional view of the device in Embodiment 1 of the present invention;

[0029] Figure 4 This is a schematic diagram showing the connection between the drug storage chamber and the drug dispensing hose in Embodiment 1 of the present invention.

[0030] In the diagram: 1. Push plate; 2. Flexible skin-contact surface; 3. Sleeve; 4. Drug storage chamber; 5. Squeezing plate; 6. Drug outlet; 7. Drug dispensing hose; 8. First connecting tube; 9. Second connecting tube; 10. First chamber; 11. Second chamber; 12. First suspension line; 13. Second suspension line; 14. First suspension ball; 15. Second suspension ball; 16. First replenishment chamber; 17. Second replenishment chamber; 18. First suspension point; 19. Second suspension point; 20. Air inlet; 21. First hemispherical opening; 22. Second hemispherical opening; 23. Replenishment drug storage chamber. Detailed Implementation

[0031] The following is in conjunction with the appendix Figure 1-4 The present invention will be described in further detail below.

[0032] Example 1: A rapid hemostatic device for abdominal trauma includes a cannula 3 and a drug storage chamber 4. The drug storage chamber 4 has a first chamber 10 and a second chamber 11. A trumpet-shaped flexible skin-adhesive surface 2 is fixedly connected around the bottom of the drug storage chamber 4. A drug dispensing tube 7 is connected to the bottom of the drug storage chamber 4, and the drug dispensing tube 7 is connected to a drug outlet 6. The drug outlet 6 can be selected according to the shape of the wound, and can be a sheet-like shape, a pointed shape as shown in the figure, or any other shape that can effectively administer drugs. The drug dispensing tube 7 connects to both the first chamber 10 and the second chamber 11. The flexible skin-adhesive surface 2 is made of medical adhesive tape and is adhered to the abdominal wall for fixation, so as to facilitate continuous drug administration.

[0033] The drug storage chamber 4 is made of silicone. Silicone has a certain elastic deformation capacity, and after being squeezed by the extrusion disc 5 and sprayed into the abdominal cavity, it can rebound on its own. Because the drug storage chamber 4 is under negative pressure after being squeezed and sprayed into the abdominal cavity, it will draw in the drug storage chamber 23 through the connecting tube during the rebound process, so as to replenish the drug in the drug storage chamber 4.

[0034] The top of the sleeve 3 is connected to a pusher plate 1, and the bottom of the sleeve 3 is provided with a squeezing plate 5. The bottom of the sleeve 3 is provided with a first connecting pipe 8 and a second connecting pipe 9 that penetrate the squeezing plate 5 and the sleeve 3. The bottom of the first connecting pipe 8 is provided with a first hemispherical opening 21, and the bottom of the second connecting pipe 9 is provided with a second hemispherical opening 22. The hemispherical openings allow the suspended ball to float to the bottom of the connecting pipe more easily, and the large opening at the bottom of the connecting pipe effectively prevents drug backflow.

[0035] The sleeve 3 has a drug storage chamber 23 inside, which is divided into a first replenishment chamber 16 and a second replenishment chamber 17. One end of the first connecting tube 8 is connected to the first replenishment chamber 16, and the other end is connected to the first chamber 10. One end of the second connecting tube 9 is connected to the second replenishment chamber 17, and the other end is connected to the second chamber 11.

[0036] The first connecting pipe 8 has a first suspension point 18 inside, the first suspension point 18 is connected to a first connecting line, and the other end of the first connecting line is connected to a first suspended ball 14. The second connecting pipe 9 has a second suspension point 19 inside, the second suspension point 19 is connected to a second connecting line, and the other end of the second connecting line is connected to a second suspended ball 15.

[0037] The top of the supplementary drug storage chamber 23 is provided with an air vent 20, and the opening of the air vent 20 is covered with tin foil. The air vent 20 connects to the first supplementary chamber 16 and the second supplementary chamber 17. The push plate 1 and the sleeve 3 are detachably connected by threads or snaps. After the push plate 1 is opened, the tin foil at the air vent 20 is torn open or punctured to create air holes, which can effectively maintain the air pressure balance in the supplementary drug storage chamber 23, prevent the drug from being drawn back from the drug storage chamber 4 into the supplementary drug storage chamber, and if the amount of drug is insufficient, it can be replenished into the supplementary drug storage chamber 23 again through this point.

[0038] Example 2: In this example, the hemostatic effects of PEG hydrogel and thrombin lyophilized powder were tested. Eight rabbits were selected for each parallel experiment, and all rabbits were subjected to the same degree of injury treatment, resulting in internal bleeding (liver puncture, wound length 3cm, depth 1cm). Different ratios of PEG hydrogel and thrombin lyophilized powder were applied to the wounds. The cessation of blood flow demonstrated the hemostatic effect. The experimental results are as follows:

[0039]

[0040]

[0041] Based on the above data, it can be seen that when the weight ratio of PEG hydrogel to thrombin lyophilized powder is between 10 and 20:1, the total amount used can be significantly reduced.

[0042] Working principle: During use, the dispensing tubing 7 and dispensing port 6 are inserted into the abdominal cavity. Pushing the pusher plate 1 drives the compression plate 5 connected to the pusher plate 1, compressing the silicone-made drug storage chamber 4. The drug is then transported through the dispensing tubing 7 and sprayed into the abdominal cavity through the dispensing port 6 to stop bleeding. After the drug storage chamber 4 is compressed and sprayed into the abdominal cavity, it enters a negative pressure state. During the rebound process, it draws in the drug replenishment storage chamber 23 through the connecting tube to replenish the drug in the storage chamber 4. When the drug height causes the first suspension ball 14 and the second suspension ball 15 to move upwards into the first hemispherical opening 21 and the second hemispherical opening 22 respectively, the drug stops flowing out, thus controlling the amount of drug in the storage chamber 4. This allows for control of the amount of drug sprayed each time. Two chambers are provided in both the drug storage chamber 4 and the replenishment storage chamber 23 because the sprayed PEG gel is usually a two-component compound. Before use, to avoid premature cross-linking and clogging of the device, it needs to be stored separately.

[0043] Upon contact with blood or body fluids, PEG gel rapidly gels through a physicochemical reaction, forming a solid barrier. Its gel network structure quickly absorbs water from the blood, concentrating platelets, thrombin, and fibrinogen, accelerating thrombus formation and promoting coagulation. The lyophilized thrombin powder mixed in directly promotes the conversion of fibrinogen into fibrin, forming a blood clot. The combined use of these two components further enhances coagulation function. Furthermore, since both PEG gel and lyophilized thrombin powder are drugs that can be absorbed by the patient's body, manual removal of residual drugs is unnecessary. Finally, because the hemostatic effect of the combination is superior to that of PEG gel alone, a smaller dosage is required for the same blood volume. Although PEG gel is self-absorbable, absorption takes time, and patients are prone to rejection reactions during this period. Therefore, using a smaller dosage is more beneficial for the patient's later recovery.

[0044] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A rapid abdominal wound hemostasis device, characterized in that: It includes a sleeve (3) and a medicine storage cavity (4), the top of the sleeve (3) is connected with a push disc (1), the bottom of the sleeve (3) is provided with a pressing disc (5), the bottom of the sleeve (3) is provided with a first connecting pipe (8) and a second connecting pipe (9) penetrating through the pressing disc (5) and the sleeve (3), the inside of the sleeve (3) is provided with a supplementary medicine storage cavity (23), the inside of the first connecting pipe (8) is provided with a first hanging part (18), the first hanging part (18) is connected with a first connecting line, the other end of the first connecting line is connected with a first suspension ball (14), the inside of the second connecting pipe (9) is provided with a second hanging part (19), the second hanging part (19) is connected with a second connecting line, the other end of the second connecting line is connected with a second suspension ball (15); the bottom of the medicine storage cavity (4) is fixedly connected with a flexible skin surface (2) in the shape of a horn, the bottom of the medicine storage cavity (4) is connected with a medicine outlet hose (7), and the medicine outlet hose (7) is connected with a medicine outlet (6).

2. The rapid abdominal wound hemostatic device according to claim 1, characterized in that: The medicine storage cavity (4) is provided with a first cavity (10) and a second cavity (11), and the supplementary medicine storage cavity (23) is divided into a first supplementary cavity (16) and a second supplementary cavity (17).

3. A rapid abdominal wound hemostatic device according to claim 2, characterized in that: One end of the first connecting pipe (8) is connected with the first supplementary cavity (16), and the other end is connected with the first cavity (10); one end of the second connecting pipe (9) is connected with the second supplementary cavity (17), and the other end is connected with the second cavity (11).

4. The rapid abdominal wound hemostatic device according to claim 2, characterized in that: The medicine outlet hose (7) simultaneously communicates the first cavity (10) and the second cavity (11).

5. The rapid abdominal wound hemostatic device of claim 1, wherein: The flexible skin surface (2) is made of medical adhesive tape, and the medicine storage cavity (4) is made of silica gel material.

6. The rapid abdominal wound hemostatic device of claim 1, wherein: The bottom of the first connecting pipe (8) is provided with a first hemispherical opening (21), and the bottom of the second connecting pipe (9) is provided with a second hemispherical opening (22).

7. The rapid abdominal wound hemostatic device of claim 1, wherein: The top of the supplementary medicine storage cavity (23) is provided with an air port (20), the air port (20) is provided with tin foil paper at the opening, and the air port (20) communicates the first supplementary cavity (16) and the second supplementary cavity (17).

8. The rapid abdominal wound hemostatic device of claim 1, wherein: The push disc (1) and the sleeve (3) are detachably connected through threads or buckles.

9. A medicament stored in the hemostatic device according to any one of claims 1 to 8, characterized in that: It comprises a PEG hydrogel and a thrombin freeze-dried powder.

10. The medicament according to claim 9, characterized by: The mass ratio of the PEG hydrogel and the thrombin freeze-dried powder is 10-20:1.

Images