External composition for promoting hair growth and application of external composition in preparation of hair growth products

Abstract

The invention relates to an external composition for promoting hair growth and application thereof in preparation of hair growth products, and belongs to the technical field of daily chemicals, the external composition comprises a hair blackening component composed of polygonum multiflorum, an absorption promoting component composed of ginger juice and white rice wine, and a hair growth component composed of cacumen biotae, cynomorium songaricum, radix semiaquilegiae and coast pine bark, the oil-control component is composed of the barks of Campanumoea maculata, the Japanese climbing fern spore and the leaves of Salvia rebaudiana. The hair-growing component provided by the invention can start from different aspects of inhibiting 5alpha-reductase, promoting cell proliferation and maintaining activeness of hair papilla cells, and the prepared external composition finished product has an excellent hair-growing promoting effect through synergistic effects; and the oil control component starts from different dimensions of resisting inflammation, resisting bacteria and reducing sebum secretion, so that the prepared external composition finished product has a remarkable effect of regulating scalp grease through a synergistic effect. The finished product of the external composition is simple in preparation process, and has the effects of promoting hair growth and regulating scalp grease.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical technology, specifically relating to a topical composition for promoting hair growth and its application in the preparation of hair growth products. Background Technology

[0002] Androgenetic alopecia, the most common type of hair loss, is characterized by overactive sebaceous glands and excessive sebum secretion in the scalp. Excessive sebum not only affects appearance and causes discomfort such as oiliness and itching, but it also provides a breeding ground for microorganisms like Malassezia, leading to scalp inflammation. Furthermore, the breakdown of sebum produces irritating free fatty acids, further exacerbating the micrometastasization of hair follicles and creating a vicious cycle of "the more oily, the more hair loss." Currently, topical products targeting hair regrowth needs are mainly divided into two categories: one is traditional hair regrowth ingredients, represented by minoxidil and finasteride (topical preparations). Although these ingredients can achieve hair regrowth by stimulating hair follicle activity and prolonging the hair growth phase, they generally lack the effect of regulating scalp sebum secretion. Some users may even experience abnormally increased sebum secretion due to the irritation of the ingredients, which can damage the scalp barrier. They cannot fundamentally improve the scalp microenvironment of patients with seborrheic alopecia. The other category is scalp care products that focus on oil control. These products often temporarily remove scalp surface oil by adding surfactants, absorbents, etc., or use zinc, ketoconazole, etc. to inhibit microbial growth and reduce inflammation-related sebum secretion. However, these products often neglect the nutritional supply and activation of the hair follicles themselves. They can only relieve the symptoms of oily scalp and cannot promote the repair of atrophied hair follicles and the growth of new hair, making it difficult to meet users' dual needs for "oil control" and "hair regrowth".

[0003] Therefore, there is an urgent need to provide a new type of topical composition that can combine the functions of promoting hair growth and regulating scalp sebum secretion, providing users with a more comprehensive product with a better user experience. Summary of the Invention

[0004] The purpose of this invention is to provide a topical composition for promoting hair growth and its application in the preparation of hair growth products, which solves the problem that the prior art cannot simultaneously promote hair growth and regulate scalp oil.

[0005] The objective of this invention can be achieved through the following technical solutions:

[0006] A topical composition for promoting hair growth, comprising the following ingredients:

[0007] Hair darkening components, absorption-enhancing components, hair growth-promoting components, oil-controlling components, and antiseptic components.

[0008] As a preferred embodiment of the present invention, the hair growth promoting topical composition comprises the following raw materials in parts by weight:

[0009] Hair darkening component 22-28 parts by weight, absorption promoting component 16-21 parts by weight, hair growth component 24-38 parts by weight, oil-controlling component 6-13 parts by weight, and antiseptic component 0.05-0.1 parts by weight.

[0010] As a preferred embodiment of the present invention, the hair-darkening component includes either Polygonum multiflorum or black sesame;

[0011] The absorption-enhancing component includes at least one of ginger juice and white rice wine;

[0012] The hair growth component includes arborvitae leaves, and also includes at least one of Cynomorium songaricum, Semiaquilegia adoxoides seeds and pine bark from the coast;

[0013] The oil-controlling components include the bark of the variegated bellflower tree, Lygodium japonicum, and Arugula leaves;

[0014] The preservative component includes either p-hydroxyacetophenone or phenoxyethanol.

[0015] Preferably, the hair-darkening component includes Polygonum multiflorum; Polygonum multiflorum can effectively promote melanin production and improve gray hair problems;

[0016] The absorption-enhancing components include ginger juice and white rice wine;

[0017] The hair growth components include arborvitae leaves, Cynomorium songaricum, Smilax china seeds, and pine bark.

[0018] Furthermore, the absorption-enhancing component includes 7-9 parts by weight of ginger juice and 9-12 parts by weight of white rice wine; ginger (ZINGIBER OFFICINALE) juice and white rice wine have the effect of promoting blood circulation in the scalp, and have a good promoting effect on the absorption and action of the active ingredients in the system.

[0019] The hair growth component includes 10-15 parts by weight of Platycladus orientalis leaves, 1-4 parts by weight of Cynomorium songaricum, 7-9 parts by weight of Scutellaria baicalensis seeds, and 6-10 parts by weight of Pine floribunda bark.

[0020] The leaves of cypress (BIOTA ORIENTALIS) can upregulate the expression of the hygroscopic factor protein, hindering the transition of hair follicles from the anagen to catagen phase, thereby promoting hair growth.

[0021] Cynomorium songaricum has an inhibitory effect on 5α-reductase, which can reduce the conversion of testosterone to dihydrotestosterone and reduce the local dihydrotestosterone level in hair follicles, thereby blocking the key signal of androgenetic alopecia.

[0022] SEMIAQUILEGIA ADOXOIDES can activate the Wnt / β-catenin signaling pathway in the outer root sheath cells of hair follicles, thereby promoting cell proliferation;

[0023] The bark of the coastal pine (PINUSPINASTER) contains proanthocyanidins, which can improve capillary permeability and maintain the activity of dermal papilla cells.

[0024] The oil-controlling component includes 1-2 parts by weight of the bark of the variegated bellflower tree, 2-5 parts by weight of Lygodium japonicum, and 3-6 parts by weight of Arugula leaves.

[0025] The bark of the variegated bellflower tree (TABEBUIA IMPETIGINOSA) contains a variety of compounds, including quinones, naphthoquinones, flavonoids, and benzoic acids, which can inhibit the production of prostaglandin E2 to a certain extent and produce a significant anti-inflammatory effect on lipopolysaccharide-mediated inflammatory responses.

[0026] The polysaccharides and flavonoids in Lygodium japonicum have broad-spectrum antibacterial effects, effectively reducing microbial activity and decreasing oily components such as free fatty acids produced by microbial decomposition of oils.

[0027] Arugula leaves contain a high amount of polyphenols such as chlorogenic acid, p-coumaric acid, caffeic acid, and ferulic acid, which can effectively reduce sebum secretion and relieve seborrheic symptoms.

[0028] As a preferred technical solution of the present invention, the method for preparing ginger juice is as follows: take ginger and distilled water, slice the ginger and add distilled water to extract the juice, filter it, and take the filtrate as ginger juice.

[0029] Furthermore, the mass ratio of ginger to distilled water is 1:3-4, and the filtration is performed using 100-mesh gauze.

[0030] As a preferred embodiment of the present invention, the alcohol content of the rice wine is 50-55 degrees.

[0031] A method for preparing a topical composition to promote hair growth includes the following steps:

[0032] (1) The raw materials of the hair darkening component, hair growth component and oil control component are crushed separately and then mixed evenly to obtain the spare material;

[0033] (2) Add distilled water to the prepared materials and soak them at a controlled temperature. After heating the distilled water to boiling, simmer over low heat, filter, and obtain the residue and filtrate. Mix the residue and distilled water and repeat the same steps to soak and simmer twice, for a total of 3 simmers. Combine the 3 filtrates to obtain the combined liquid, concentrate, and obtain the Chinese herbal medicine liquid.

[0034] (3) Mix the herbal liquid, absorption-promoting components and preservative components and stir evenly to obtain the finished product of the external composition.

[0035] As a preferred technical solution of the present invention, the pulverization in step (1) is pulverization to 10 mesh.

[0036] As a preferred technical solution of the present invention, the mass ratio of the spare material and distilled water in step (2) is 1:6-8; the concentration is to concentrate the mass concentration of the combined liquid to 1-2g / mL.

[0037] As a preferred technical solution of the present invention, the temperature of the temperature-controlled soaking in step (2) is 70-80℃ and the time is 1-2h; the simmering time is 30-45min; and the filtration is done with 80-mesh gauze.

[0038] The application of a hair growth promoting topical composition in the preparation of hair growth products, wherein it is added at 3-5% of the total mass of the hair growth products.

[0039] As a preferred embodiment of the present invention, the dosage form of the hair growth product includes, but is not limited to, topical application, spray, and drops.

[0040] The beneficial effects of this invention are:

[0041] (1) This application uses Platycladus orientalis leaves as the main raw material for promoting hair growth. It promotes hair growth by upregulating the expression of the Hedgehog factor protein. At the same time, it innovatively supplements the product with Cynomorium songaricum, Scutellaria baicalensis seeds and pine bark of Pinus hainanensis, which work from different aspects such as inhibiting 5α-reductase, promoting cell proliferation and maintaining the activity of hair papilla cells, so that the prepared topical composition has excellent hair growth promotion effect.

[0042] (2) This application uses the bark of the variegated bellflower tree, lygodium japonicum and arugula leaves in combination to work from different dimensions of anti-inflammatory, antibacterial and sebum reduction, so that the finished topical composition has a significant effect on regulating scalp oil.

[0043] (3) Traditional Chinese medicine has the advantages of convenient material sourcing and simple production process. At the same time, its processed products have good compatibility with most daily chemical ingredients. Therefore, this application combines different traditional Chinese medicines to successfully prepare a topical composition product that promotes hair growth and regulates scalp oil. Moreover, the raw materials of this product are all natural, the formula is mild and has low irritation, and it is suitable for use by different people of all ages. Attached Figure Description

[0044] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0045] Figure 1 This is a comparison image of the hair growth-promoting topical trial sample prepared in Example 1 of this application, and volunteer number 1 before and after use;

[0046] Figure 2 This is a comparison image of the hair growth promoter topical trial sample prepared in Example 1 of this application, and volunteer number 2 before and after use;

[0047] Figure 3 This is a comparison image of the hair growth promoter topical trial sample prepared in Example 1 of this application, and volunteer number 3 before and after use. Detailed Implementation

[0048] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0049] Examples 1-3

[0050] A topical composition for promoting hair growth comprises the following ingredients in parts by weight as shown in Table 1:

[0051] Table 1

[0052]

[0053] The method for preparing ginger juice is as follows: take ginger and distilled water at a mass ratio of 1:3.5, slice the ginger and add distilled water to extract the juice, filter it with 100-mesh gauze, and take the filtrate as ginger juice.

[0054] The method for preparing the hair growth-promoting topical composition includes the following steps:

[0055] (1) The raw materials of the hair darkening component, hair growth component and oil control component are crushed to 10 mesh and then mixed evenly to obtain the spare material;

[0056] (2) Add distilled water to the prepared material and soak at 75°C for 1.5 hours. Then heat the water until it boils and simmer for 35 minutes. Filter the mixture through 80-mesh gauze to obtain the residue and filtrate. Mix the residue and distilled water and repeat the same steps as above for soaking and simmering twice, for a total of 3 simmerings. Combine the filtrates from the 3 simmerings to obtain the combined liquid. Concentrate the mass concentration of the combined liquid to 2 g / mL to obtain the herbal medicine liquid.

[0057] The mass ratio of the prepared material to distilled water is 1:7;

[0058] (3) Mix the herbal liquid, absorption-promoting components and preservative components and stir evenly to obtain the finished product of the external composition.

[0059] Comparative Example 1

[0060] Compared with Example 1, the difference is that no Platycladus orientalis leaves were added in Comparative Example 1, and the missing weight was made up with Cynomorium songaricum, Scutellaria baicalensis and pine bark in a mass ratio of 2.5:9:8. All other operation steps and parameters remained unchanged.

[0061] Comparative Example 2

[0062] Compared with Example 1, the difference is that Cynomorium songaricum was not added in Comparative Example 3, and the missing weight was made up with Platycladus orientalis leaves, Scutellaria baicalensis seeds and pine bark in a mass ratio of 12:9:8. All other operation steps and parameters remained unchanged.

[0063] Comparative Example 3

[0064] Compared with Example 1, the difference is that no Tiankui seeds were added in Comparative Example 3, and the missing weight was made up with Platycladus orientalis leaves, Cynomorium songaricum and pine bark in a mass ratio of 12:2.5:8. All other operating steps and parameters remained unchanged.

[0065] Comparative Example 4

[0066] Compared with Example 1, the difference is that no pine bark was added in Comparative Example 4, and the missing weight was made up with Platycladus orientalis leaves, Cynomorium songaricum and Scutellaria baicalensis in a mass ratio of 12:2.5:9. All other operating steps and parameters remained unchanged.

[0067] Comparative Example 5

[0068] Compared with Example 1, the difference is that no bark of the variegated bellflower tree was added in Comparative Example 5, and the missing weight was made up with sea lysimachia and arugula leaves in a mass ratio of 1:3. All other operation steps and parameters remained unchanged.

[0069] Comparative Example 6

[0070] Compared with Example 1, the difference is that no Lygodium japonicum was added in Comparative Example 6, and the missing weight was made up with the bark of Bellflower Tree and Arugula leaves in a mass ratio of 1:3. All other operation steps and parameters remained unchanged.

[0071] Comparative Example 7

[0072] Compared with Example 1, the difference is that Arugula spp. leaves were not added in Comparative Example 7, and the missing weight was made up with Campsis grandiflora bark and Lygodium japonicum in a mass ratio of 1:1. All other operation steps and parameters remained unchanged.

[0073] Test Example 1

[0074] (1) Trial sample: The topical compositions obtained in Examples 1-3 and Comparative Examples 1-4 were mixed with water at a ratio of 1:19 to obtain a hair growth promotion topical trial sample;

[0075] (2) Subjects: Volunteers aged 20-45 with baldness, alopecia areata, or total baldness, with half males and half females. The volunteers were randomly divided into 7 groups of 12 people each. The topical hair growth promoters prepared in Examples 1-3 and Comparative Examples 1-4 were used respectively.

[0076] (3) Instructions for use: After washing and drying hair, apply the sample evenly to the affected area of ​​the scalp and gently massage with your fingertips for 5 minutes. Use once in the morning and once in the evening. The dosage is 0.5 mL / 10 cm. 2 Scalp, use continuously for 8 weeks;

[0077] (4) Evaluation criteria for therapeutic efficacy:

[0078] Significant effect: Hair increases significantly or there is a significant increase in new vellus hair, with a density increase of more than 50% or a hair diameter increase of more than 50%;

[0079] Effective: Increased hair growth or a certain number of new vellus hairs, with a 30-50% increase in density or a 30-50% increase in hair diameter;

[0080] Ineffective: No significant increase in hair growth, or only a small amount of new vellus hair appears and falls out quickly;

[0081] The final results are shown in Table 1.

[0082] Table 1

[0083] Significant effect (example) Valid (example) Invalid (example) Example 1 10 2 0 Example 2 9 3 0 Example 3 10 2 0 Comparative Example 1 4 5 3 Comparative Example 2 5 4 3 Comparative Example 3 6 4 2 Comparative Example 4 5 5 2

[0084] Figure 1-3 These are before-and-after comparison images of the hair growth-promoting topical trial sample prepared in Example 1 of this test case, and volunteers 1-3 before and after use.

[0085] As shown in Table 1, the topical composition obtained in this application exhibits excellent hair growth promoting effects. This is because this application uses Platycladus orientalis leaves as the main hair growth promoting ingredient, which exerts its hair growth promoting effect by upregulating the expression of the Hedgehog factor protein. At the same time, it innovatively supplements the product with Cynomorium songaricum, Scutellaria baicalensis seeds, and Pinus hainanensis bark, which work synergistically from different aspects such as inhibiting 5α-reductase, promoting cell proliferation, and maintaining the activity of hair papilla cells, respectively, so that the obtained topical composition has excellent hair growth promoting effects.

[0086] Test Example 2

[0087] (1) Trial sample: The topical compositions obtained in Examples 1-3 and Comparative Examples 5-7 were mixed with water at a ratio of 1:19 to obtain a hair growth promotion topical trial sample;

[0088] (2) Subjects: Volunteers aged 20-45 who felt they had excessive scalp oil, with half male and half female. The volunteers were randomly divided into 6 groups of 12 people each. The topical hair growth promoters prepared in Examples 1-3 and Comparative Examples 5-7 were used respectively.

[0089] (3) Instructions for use: After washing and drying hair, apply the sample evenly to the scalp and gently massage with your fingertips for 5 minutes. Use once every night, applying to the entire scalp. The dosage is 0.5 mL / 10 cm. 2 Scalp, use continuously for 4 weeks;

[0090] (4) Test environment: Temperature 23℃, relative humidity 50%, test after sitting still for 30 minutes;

[0091] (5) Test results: All volunteers were required to wash their hair before the test. The sebum content of the volunteers’ scalp in a fixed area was tested on day 0 and day 28 using a Sebumeter SM815 (measured 3 times and the average value was taken). The difference in sebum content before and after the trial sample was calculated for each group of volunteers. The final results are shown in Table 2.

[0092] Table 2

[0093]

[0094] As can be seen from Table 2, this application, by using the bark of the variegated bellflower tree, Lygodium japonicum, and Arugula leaves in combination, can work synergistically from different dimensions of anti-inflammatory, antibacterial, and sebum reduction, so that the resulting topical composition has a significant effect on regulating scalp oil.

[0095] In the description of this specification, the references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0096] The above description is merely an example and illustration of the concept of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described or use similar methods to replace them, as long as they do not deviate from the concept of the invention or exceed the scope defined in the claims, they should all fall within the protection scope of the present invention.

Claims

1. A topical composition for promoting hair growth, characterized in that, Including the following raw materials: Hair darkening components, absorption-promoting components, hair growth-promoting components, oil-controlling components, and antiseptic components.

2. The topical composition for promoting hair growth according to claim 1, characterized in that, The topical composition for promoting hair growth comprises the following ingredients in parts by weight: Hair darkening component 22-28 parts by weight, absorption promoting component 16-21 parts by weight, hair growth component 24-38 parts by weight, oil-controlling component 6-13 parts by weight, and antiseptic component 0.05-0.1 parts by weight.

3. The topical composition for promoting hair growth according to claim 1, characterized in that, The hair-darkening component includes either Polygonum multiflorum or black sesame; The absorption-enhancing component includes at least one of ginger juice and white rice wine; The hair growth component includes arborvitae leaves, and also includes at least one of Cynomorium songaricum, Semiaquilegia adoxoides seeds and pine bark from the coast; The oil-controlling components include the bark of the variegated bellflower tree, Lygodium japonicum, and Arugula leaves; The preservative component includes either p-hydroxyacetophenone or phenoxyethanol.

4. The topical composition for promoting hair growth according to claim 3, characterized in that, The hair-darkening component includes Polygonum multiflorum; the absorption-promoting component includes ginger juice and white rice wine; the hair-growth component includes Platycladus orientalis leaves, Cynomorium songaricum, Semiaquilegia adoxoides seeds and Pinus hainanensis bark.

5. The topical composition for promoting hair growth according to claim 3, characterized in that, The absorption-enhancing component includes 7-9 parts by weight of ginger juice and 9-12 parts by weight of white rice wine. The hair growth component includes 10-15 parts by weight of Platycladus orientalis leaves, 1-4 parts by weight of Cynomorium songaricum, 7-9 parts by weight of Scutellaria baicalensis seeds, and 6-10 parts by weight of Pine floribunda bark. The oil-controlling component includes 1-2 parts by weight of the bark of the variegated bellflower tree, 2-5 parts by weight of Lygodium japonicum, and 3-6 parts by weight of Arugula officinalis leaves.

6. The topical composition for promoting hair growth according to claim 3, characterized in that, The alcohol content of the rice wine is 50-55 degrees.

7. A method for preparing a topical hair growth promoting composition as described in any one of claims 1-6, characterized in that, Includes the following steps: (1) The raw materials of the hair darkening component, hair growth component and oil control component are crushed separately and then mixed evenly to obtain the spare material; (2) Add distilled water to the prepared materials and soak them at a controlled temperature. After heating the distilled water to boiling, simmer over low heat, filter, and obtain the residue and filtrate. Mix the residue and distilled water and repeat the same steps to soak and simmer twice, for a total of 3 simmers. Combine the 3 filtrates to obtain the combined liquid, concentrate, and obtain the Chinese herbal medicine liquid. (3) Mix the herbal liquid, absorption-promoting components and preservative components and stir evenly to obtain the finished product of the external composition.

8. The method for preparing the topical hair growth promoting composition according to claim 7, characterized in that, The pulverization in step (1) is pulverization to 10 mesh; the mass ratio of the prepared material and distilled water in step (2) is 1:6-8; the concentration is to concentrate the mass concentration of the combined liquid to 1-2 g / mL; the temperature of the temperature-controlled soaking in step (2) is 70-80℃ and the time is 1-2 h; the simmering time is 30-45 min; the filtration is to filter with 80 mesh gauze.

9. The use of a topical hair growth promoting composition as described in any one of claims 1-6 in the preparation of a hair growth product, wherein the composition is added at 3-5% of the total mass of the hair growth product.

10. The application of the topical hair growth promoting composition according to claim 9 in the preparation of hair growth products, characterized in that, The dosage forms of the hair growth products include topical creams, sprays, and drops.

Images