Traditional Chinese medicine spray for treating allergic rhinitis and preparation method thereof

Abstract

According to the traditional Chinese medicine compatibility principle of monarch, minister, assistant and guide, firstly, 11 medicinal materials are placed in a drying oven at the temperature of 50-60 DEG C to be dried to constant weight, the raw materials are crushed respectively and then sieved through a 200-mesh sieve, and the traditional Chinese medicine spray is prepared. The preparation method comprises the following steps: taking 15-20 parts of radix sophorae flavescentis, 10-15 parts of flos magnoliae liliflorae, 10-15 parts of fructus forsythiae, 10-15 parts of cortex moutan charcoal, 10-15 parts of fructus xanthii, 5-10 parts of oldenlandia diffusa, 5-10 parts of lithospermum erythrorhizon, 5-10 parts of honeysuckle, 3-5 parts of dendrobium officinale, 3-5 parts of mint, 3-5 parts of liquorice and other medicinal materials, reasonably matching and uniformly mixing to obtain a micro-powder mixture; and taking the micro-powder mixture, carrying out two times of distillation treatment, and mixing the extracting solutions obtained by the two times of distillation treatment to obtain the traditional Chinese medicine spray. As a pure traditional Chinese medicine preparation, the traditional Chinese medicine preparation has the characteristics of remarkable curative effect and safety in use, is low in cost and simple to prepare, and is convenient to carry as a spray.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to a traditional Chinese medicine spray for treating allergic rhinitis and its preparation method. Background Technology

[0002] Allergic rhinitis has complex causes. Clinically, it often manifests as an overreaction of the body's immune system to environmental allergens, such as pollen and dust mites, leading to chronic inflammation of the mucous membranes. The main symptoms are episodic sneezing, runny nose, and nasal congestion. Genetic factors, as well as environmental allergens such as fungal spores, dust mites, animal excrement, and certain foods, can all trigger allergic rhinitis. The global incidence of this disease is increasing annually, and many patients lose hope after years of unsuccessful treatment.

[0003] Currently, there are many types of medications for allergic rhinitis on the market, mainly including nasal corticosteroids, antihistamines, decongestants, and leukotriene inhibitors. Nasal corticosteroids (such as budesonide and mometasone furoate) have strong anti-inflammatory effects and can effectively relieve symptoms such as nasal congestion, runny nose, and sneezing, making them first-line treatments for allergic rhinitis. The disadvantage is that some patients experience local adverse reactions, such as nasal dryness, stinging, and nosebleeds. Long-term use may affect the health of the nasal mucosa, and in rare cases, may even lead to nasal septum perforation. Antihistamine nasal sprays (such as azelastine) can quickly relieve nasal itching, sneezing, and runny nose. They are hormone-free and suitable for short-term or intermittent use. The disadvantage is that they have limited effectiveness in nasal congestion and usually need to be used in combination with decongestants or corticosteroids. Some patients may experience a burning sensation or bitter taste in the nasal cavity. Decongestants (such as oxymetazoline hydrochloride) can quickly constrict nasal mucosal blood vessels and relieve nasal congestion, and are often used for acute symptom relief. The disadvantages are that continued use for more than 7 days may lead to rebound nasal congestion, worsening symptoms, and long-term use may damage the nasal mucosa. The advantages of anti-leukotriene drugs (such as montelukast sodium) are that, as oral preparations, they are suitable for allergic rhinitis patients with comorbid asthma, reducing nasal and airway inflammation. The disadvantages are that they are less effective for nasal congestion, usually requiring combination with other medications, and a small number of patients may experience insomnia and mood swings (the FDA has issued related warnings). Summary of the Invention

[0004] To address the aforementioned problems, the present invention aims to provide a traditional Chinese medicine spray for treating allergic rhinitis and its preparation method. The formulation of the present invention is a pure traditional Chinese medicine preparation, suitable for recurrent allergic rhinitis, with significant efficacy and safe use, and low cost. As a liquid spray, it is convenient to carry, and patients can use it daily according to their symptoms.

[0005] The herbal spray of this invention uses a raw material composition based on the principle of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine formulation. It consists of 11 medicinal herbs: 15-20 parts Sophora flavescens, 10-15 parts Magnolia biondii, 10-15 parts Forsythia suspensa, 10-15 parts charred Paeonia suffruticosa, 10-15 parts Xanthium sibiricum, 5-10 parts Hedyotis diffusa, 5-10 parts Lithospermum erythrorhizon, 5-10 parts Lonicera japonica, 3-5 parts Dendrobium officinale, 3-5 parts Mentha haplocalyx, and 3-5 parts Glycyrrhiza uralensis. In preparation, the above raw materials are first dried to constant weight, then crushed and sieved separately, and mixed evenly according to the specified proportions to obtain a fine powder mixture. This mixture is then subjected to two distillation processes, collecting the effective secondary metabolites of the herbs in stages. The extracts obtained from the two distillation processes are mixed to obtain the herbal spray.

[0006] In terms of formulation, Sophora flavescens and Magnolia biondii are the principal herbs, Forsythia suspensa and Paeonia suffruticosa charcoal are the assistant herbs, Xanthium sibiricum, Hedyotis diffusa, Lithospermum erythrorhizon and Lonicera japonica are the adjuvant herbs, and Dendrobium officinale, Mentha haplocalyx and Glycyrrhiza uralensis

[0007] The present invention provides a method for preparing a traditional Chinese medicine spray for treating allergic rhinitis, which specifically includes the following steps:

[0008] (1) Take Sophora flavescens, Magnolia biondii, Forsythia suspensa, Paeonia suffruticosa charcoal, Xanthium sibiricum, Hedyotis diffusa, Lithospermum erythrorhizon, Lonicera japonica, Dendrobium officinale, Mentha haplocalyx and Glycyrrhiza uralensis as raw materials respectively, dry them in an oven until constant weight, grind the above raw materials separately and sieve them, and mix them evenly according to the proportion to obtain micro powder mixture.

[0009] (2) A portion of the micro powder mixture obtained in step (1) is subjected to a first distillation treatment, and the extract obtained from the first distillation treatment is collected. Then, distilled water and another portion of the micro powder mixture obtained in step (1) are added to the distillation device for a second distillation treatment. The extract obtained from the second distillation treatment is collected and mixed with the extract obtained from the first distillation treatment to obtain a traditional Chinese medicine composition spray.

[0010] Furthermore, the Chinese medicinal materials required in step (1) include Sophora flavescens, Magnolia biondii, Forsythia suspensa, Paeonia suffruticosa charcoal, Xanthium sibiricum, Hedyotis diffusa, Lithospermum erythrorhizon, Lonicera japonica, Dendrobium officinale, Mentha haplocalyx, and Glycyrrhiza uralensis.

[0011] Furthermore, the oven temperature in step (1) is 50-60℃.

[0012] Furthermore, in step (1), the raw materials are ground and crushed separately using a grinder and then sieved.

[0013] Furthermore, in step (1), the raw materials are ground separately and then passed through a 200-mesh sieve.

[0014] Furthermore, in step (1), 15-20 parts of Sophora flavescens, 10-15 parts of Magnolia biondii, 10-15 parts of Forsythia suspensa, 10-15 parts of Paeonia suffruticosa charcoal, 10-15 parts of Xanthium sibiricum, 5-10 parts of Hedyotis diffusa, 5-10 parts of Lithospermum erythrorhizon, 5-10 parts of Lonicera japonica, 3-5 parts of Dendrobium officinale, 3-5 parts of Mentha haplocalyx and 3-5 parts of Glycyrrhiza uralensis, a total of 11 Chinese medicinal herbs, are mixed evenly according to the following weight proportions.

[0015] Furthermore, in step (2), the first distillation process has a material-to-liquid ratio of 1:10-15.

[0016] Furthermore, in step (2), the second distillation process has a material-to-liquid ratio of 1:10-15, which is the ratio of the additional micro-powder mixture to the added distilled water.

[0017] Furthermore, in step (2), both the first and second distillation processes are carried out at 100-110℃.

[0018] The present invention also provides a traditional Chinese medicine spray for treating allergic rhinitis prepared according to the above method.

[0019] Store the above-mentioned Chinese herbal spray in a sealed container away from light. When opening, dispense it into sterile brown glass spray bottles. It can be stored at room temperature for 110-120 days without any preservatives. Alternatively, preservatives can be added according to relevant drug requirements for commercial use.

[0020] The active pharmaceutical ingredients and their pharmacological effects in this invention are as follows:

[0021] Sophora flavescens is the dried root of Sophora flavescens, a plant belonging to the genus Sophora in the family Fabaceae. Its effects include treating damp-heat diarrhea, damp-heat leukorrhea, vulvar swelling and itching, urticaria, eczema, pruritus, and anti-allergic effects. It also has the functions of clearing heat and drying dampness, killing parasites and relieving itching, and is effective for damp-heat syndrome in allergic rhinitis.

[0022] Magnolia flower is the dried flower bud of Magnolia liliiflora, belonging to the genus Magnolia in the family Magnoliaceae. Its effects include dispelling cold and clearing the nasal passages, and expelling wind; it is mainly used to treat common cold due to wind-cold, with symptoms such as nasal congestion and runny nose.

[0023] Forsythia is the mature fruit of Forsythia suspensa, a plant belonging to the Oleaceae family. Its effects include clearing heat and detoxifying, reducing swelling and dissipating nodules, dispersing wind-heat, and anti-allergy. It is known as a master of treating sores and ulcers.

[0024] Danpi charcoal is the dried root bark of Paeonia suffruticosa, a plant in the Ranunculaceae family. The process involves stir-frying the peony bark in a pot over high heat until it turns charred black, retaining its properties, then spraying it with water, removing it, and letting it cool completely to obtain danpi charcoal. Its effects include clearing heat and cooling the blood, promoting blood circulation and removing blood stasis, and anti-allergy properties. It can treat carbuncles, boils, injuries from falls, and relieve nasal congestion and swelling.

[0025] Xanthium strumarium is the fruit of Xanthium strumarium in the family Asteraceae. Its effects include antibacterial and anti-inflammatory properties, relieving itching, dispelling wind and cold, benefiting the liver and lungs, and assisting Magnolia biondii in opening the orifices.

[0026] Hedyotis diffusa, the dried aerial part of the herb belonging to the Rubiaceae family, has the following effects: clearing heat and detoxifying, relieving pain and dissipating nodules, promoting blood circulation and removing dampness, and relieving mucosal congestion.

[0027] Lithospermum erythrorhizon, belonging to the Boraginaceae family, is used medicinally for its dried roots. Its effects include cooling the blood and promoting blood circulation, anti-allergy, relieving nasal congestion, and treating febrile rashes, burns, eczema, erysipelas, and other diseases.

[0028] Honeysuckle is the flower of Lonicera japonica, a plant belonging to the genus Lonicera in the family Caprifoliaceae. Its medicinal properties include clearing heat and detoxifying, treating febrile diseases, dysentery caused by heat toxins, carbuncles, boils, scrofula, etc.

[0029] Dendrobium officinale is the dried stem of a plant in the Dendrobium genus of the Orchidaceae family. Its effects include: treating heat-related illnesses with fluid depletion, dry mouth and thirst, stomach yin deficiency, nourishing the skin, and having heat-clearing, anti-inflammatory, and moisturizing effects.

[0030] Peppermint is the dried aerial part of the plant Mentha haplocalyx, belonging to the Lamiaceae family. Its effects include clearing heat and detoxifying, and it is used to treat neuralgia, itchy skin, rashes, and urticaria. It also promotes transdermal absorption.

[0031] Licorice: The rhizome of Glycyrrhiza uralensis, a plant belonging to the genus Glycyrrhiza in the family Fabaceae. Its effects include: treating asthma and cough, carbuncles and sores, sore throat, anti-inflammatory and anti-allergic properties, and harmonizing other medicines. It is known as the "oldest medicine in China".

[0032] The traditional Chinese medicine spray of the present invention incorporates the concept of "sovereign, ministerial, adjuvant, and courier" and modern extraction techniques in its preparation method. The preparation method is simple, low-cost, saves raw materials, and has a high patient acceptance rating. The compatibility characteristics of this traditional Chinese medicine composition are distinct levels, clear division of labor among the sovereign, ministerial, adjuvant, and courier herbs, and an orderly primary and secondary relationship. It emphasizes the balance of cold and warmth. Heat-clearing herbs such as Sophora flavescens and Forsythia suspensa are combined with warm-natured herbs such as Magnolia flower and Xanthium sibiricum to avoid excessive cold or heat. At the same time, it takes into account both local and overall regulation. It targets both local nasal symptoms (such as clearing the nasal passages and anti-inflammatory) and overall immune regulation (such as clearing heat and detoxifying, enhancing immunity). It conforms to traditional Chinese medicine theory and is suitable for patients with allergic rhinitis mainly presenting with damp-heat syndrome, with both efficacy and safety. The specific analysis is as follows: The sovereign herb, Sophora flavescens (15 - 20%), has the functions of clearing heat and drying dampness, killing insects and relieving itching, targeting the damp-heat syndrome of allergic rhinitis; Magnolia flower (10 - 15%) has the function of warming the channels and opening the nasal passages, specifically treating nasal congestion and runny nose, and is an important herb in rhinology. The two work together to relieve the main symptoms such as nasal itching, sneezing, and nasal congestion. The ministerial herb, Forsythia suspensa (10 - 15%), has the functions of clearing heat and detoxifying, dissipating nodules and relieving swelling, assisting the sovereign herb in clearing heat; Carbonized Moutan cortex (10 - 15%) cools the blood and promotes blood circulation, relieving nasal mucosa congestion and swelling. The two enhance the anti-inflammatory and anti-allergic effects and reduce nasal congestion and inflammatory responses. The adjuvant herbs, Xanthium sibiricum (10 - 15%), have the functions of dispelling wind-cold and opening the nasal passages, assisting the opening of the nasal passages by Magnolia flower; Hedyotis diffusa (5 - 10%) has the functions of clearing heat and detoxifying, enhancing the anti-inflammatory effect; Lithospermum erythrorhizon (5 - 10%) cools the blood and promotes blood circulation, relieving mucosal congestion; Lonicera japonica (5 - 10%) has the functions of clearing heat and detoxifying, inhibiting allergic reactions. The adjuvant herbs regulate multiple targets, taking into account anti-inflammatory, anti-allergic, and mucosal repair effects. The courier herbs, Dendrobium officinale (3 - 5%), have the function of nourishing yin and promoting the production of body fluids, preventing yin damage caused by dry herbs; Mentha haplocalyx (3 - 5%) has the function of dispersing wind-heat on the body surface, relieving nasal congestion and giving a cool feeling, and enhancing the transdermal absorption of the drug; Glycyrrhiza glabra (3 - 5%) harmonizes all the herbs, detoxifies and relieves urgency. The function of the courier herbs is to balance the cold and warmth properties of the formula and improve the comfort of medication. The modern extraction technique uses distillation. The obtained liquid is nearly transparent and colorless, avoiding the problems of color, texture, and anti-corrosion brought by traditional Chinese herbal medicine processing techniques. At the same time, since traditional Chinese medicine needs to be decocted two to three times, a two-stage distillation process is also adopted, which can fully stimulate the active ingredients contained in the herbs, and is an innovation that adheres to and improves the traditional processing and extraction techniques of Chinese herbal medicine.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] The preparation method of this invention is simple, low-cost, and saves raw materials. It has the characteristics of significant efficacy and safety in use. Patients can take the medicine in a timely manner according to their own symptoms every day, achieving short-term effective relief and long-term reduction of the attack frequency until cure. It has a broad market prospect. The liquid spray is convenient to carry, and can achieve certain economic and social benefits. Detailed implementation method

[0035] To better understand the content of this invention, specific embodiments will be used to further illustrate the invention below. The following embodiments are based on the technology of this invention and provide detailed implementation methods and operating steps; however, the scope of protection of this invention is not limited to the following embodiments.

[0036] Example 1:

[0037] (1) Place the required Chinese medicinal materials in an oven at 50℃ and dry them to constant weight. Grind them separately and pass them through a 200-mesh sieve. Take 15g of Sophora flavescens, 15g of Magnolia biondii, 10g of Forsythia suspensa, 10g of charred Paeonia suffruticosa, 10g of Xanthium sibiricum, 10g of Hedyotis diffusa, 10g of Lithospermum erythrorhizon, 5g of Lonicera japonica, 5g of Dendrobium officinale, 5g of Mentha haplocalyx and 5g of Glycyrrhiza uralensis, a total of 11 medicinal materials, mix them evenly to obtain a micro powder mixture.

[0038] (2) A 100g sample of the micro powder mixture obtained in step (1) is subjected to a first distillation at 110°C, wherein the material-to-liquid ratio is 1:10. The extract obtained from the first distillation is collected. Then, 1000mL of distilled water and another 100g sample of the micro powder mixture obtained in step (1) are added to the distillation apparatus and subjected to a second distillation at 110°C. The material-to-liquid ratio of the second distillation, i.e., the ratio of the added micro powder mixture to the distilled water, is 1:10. The extract obtained from the second distillation is collected and mixed with the extract obtained from the first distillation to obtain the traditional Chinese medicine spray.

[0039] Store the above-mentioned Chinese herbal spray in a sealed container away from light, and then dispense it into sterilized brown glass spray bottles. It can be stored at room temperature for 115 days without adding any preservatives.

[0040] Example 2:

[0041] (1) Place the required Chinese medicinal materials in an oven at 50℃ and dry them to constant weight. Grind them separately and pass them through a 200-mesh sieve. Take 200g of Sophora flavescens, 150g of Magnolia biondii, 150g of Forsythia suspensa, 100g of charred Paeonia suffruticosa, 100g of Xanthium sibiricum, 50g of Hedyotis diffusa, 50g of Lithospermum erythrorhizon, 50g of Lonicera japonica, 50g of Dendrobium officinale, 50g of Mentha haplocalyx and 50g of Glycyrrhiza uralensis, a total of 11 medicinal materials, mix them evenly to obtain a micro powder mixture.

[0042] (2) A 1000g sample of the micro powder mixture obtained in step (1) is subjected to a first distillation at 110°C, wherein the material-to-liquid ratio is 1:15. The extract obtained from the first distillation is collected. Then, 15000mL of distilled water and another 1000g sample of the micro powder mixture obtained in step (1) are added to the distillation apparatus and subjected to a second distillation at 110°C. The material-to-liquid ratio of the second distillation, i.e., the ratio of the added micro powder mixture to the distilled water, is 1:15. The extract obtained from the second distillation is collected and mixed with the extract obtained from the first distillation to obtain the traditional Chinese medicine spray.

[0043] Store the above-mentioned Chinese herbal spray in a light-proof, sealed container, and then repackage it into sterile brown glass dispensing bottles. It can be stored at room temperature for 120 days without adding any preservatives.

[0044] Example 3:

[0045] (1) Place the required Chinese medicinal materials in an oven at 50℃ and dry them to constant weight. Take 80g of Sophora flavescens, 70g of Magnolia biondii, 70g of Forsythia suspensa, 70g of charred Paeonia suffruticosa, 70g of Xanthium sibiricum, 30g of Hedyotis diffusa, 30g of Lithospermum erythrorhizon, 30g of Lonicera japonica, 20g of Dendrobium officinale, 15g of Mentha haplocalyx and 15g of Glycyrrhiza uralensis, a total of 11 medicinal materials, crush them separately with a grinder and pass them through a 200-mesh sieve. After mixing them evenly, a micro powder mixture is obtained.

[0046] (2) A 500g sample of the micro powder mixture obtained in step (1) is subjected to a first distillation at 100°C, wherein the material-to-liquid ratio is 1:12. The extract obtained from the first distillation is collected. Then, 6000mL of distilled water and another 500g sample of the micro powder mixture obtained in step (1) are added to the distillation apparatus and subjected to a second distillation at 100°C. The material-to-liquid ratio of the second distillation, i.e., the ratio of the added micro powder mixture to the distilled water, is 1:12. The extract obtained from the second distillation is collected and mixed with the extract obtained from the first distillation to obtain the traditional Chinese medicine spray.

[0047] Store the above-mentioned Chinese herbal spray in a light-proof, sealed container, and then repackage it into sterile brown glass bottles. It can be stored at room temperature for 110 days without any preservatives.

[0048] The herbal spray prepared in Example 1 was used to conduct a pharmacodynamic evaluation test on 40 patients with allergic rhinitis.

[0049] The herbal spray prepared in Example 2 was used to conduct a pharmacodynamic evaluation test on 30 patients with allergic rhinitis.

[0050] The herbal spray prepared in Example 3 was used to conduct a pharmacodynamic evaluation test on 30 patients with allergic rhinitis.

[0051] Experimental methods and statistics:

[0052] 1. Test subjects were instructed to use the herbal spray in their nasal cavity daily according to their symptoms for 6 months.

[0053] 2. Have test subjects fill out a rating of the efficacy of the herbal spray, categorized into three levels: Level I, patients felt it was very effective, their nasal cavity felt comfortable after spraying, and the frequency of attacks decreased in the later stages; Level II, patients felt good, their nasal cavity felt relieved after spraying, and the frequency of attacks remained the same in the later stages; Level III, patients reported no significant improvement.

[0054] As can be seen from Table 1, the overall effectiveness rate of the traditional Chinese medicine spray is as high as 93%.

[0055] Table 1 shows the effectiveness rate of traditional Chinese medicine sprays.

[0056] Drug efficacy level Ⅰ Ⅱ Ⅲ Example 1 31 6 3 Example 2 23 5 2 Example 3 22 6 2 total 76 17 7

[0057] The above description is merely an embodiment of the present invention and is not intended to limit the present invention in any way. The present invention can also have other embodiments based on the above structure and function, which will not be listed hereafter. Therefore, any simple modifications, equivalent changes, and alterations made by those skilled in the art to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A method for preparing a traditional Chinese medicine spray for treating allergic rhinitis, characterized in that, Specifically, the steps include the following: (1) Take Sophora flavescens, Magnolia biondii, Forsythia suspensa, Paeonia suffruticosa charcoal, Xanthium sibiricum, Hedyotis diffusa, Lithospermum erythrorhizon, Lonicera japonica, Dendrobium officinale, Mentha haplocalyx and Glycyrrhiza uralensis as raw materials respectively, dry them in an oven until constant weight, grind the above raw materials separately and sieve them, and mix them evenly according to the proportion to obtain micro powder mixture. (2) A portion of the micro powder mixture obtained in step (1) is subjected to a first distillation treatment, and the extract obtained from the first distillation treatment is collected. Then, distilled water and another portion of the micro powder mixture obtained in step (1) are added to the distillation device for a second distillation treatment. The extract obtained from the second distillation treatment is collected and mixed with the extract obtained from the first distillation treatment to obtain a traditional Chinese medicine composition spray.

2. The preparation method of the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (1), the oven temperature is 50-60℃.

3. The method for preparing the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (1), the raw materials are ground and crushed by a grinder and then sieved.

4. The preparation method of the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (1), the raw materials are ground and then passed through a 200-mesh sieve.

5. The method for preparing the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (1), take 15-20 parts of Sophora flavescens, 10-15 parts of Magnolia biondii, 10-15 parts of Forsythia suspensa, 10-15 parts of Paeonia suffruticosa charcoal, 10-15 parts of Xanthium sibiricum, 5-10 parts of Hedyotis diffusa, 5-10 parts of Lithospermum erythrorhizon, 5-10 parts of Lonicera japonica, 3-5 parts of Dendrobium officinale, 3-5 parts of Mentha haplocalyx and 3-5 parts of Glycyrrhiza uralensis, and mix them evenly.

6. The method for preparing the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (2), the first distillation process has a material-to-liquid ratio of 1:10-15.

7. The method for preparing the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (2), the second distillation process has a material-to-liquid ratio of 1:10-15, which is the ratio of the additional micro-powder mixture to the added distilled water.

8. The method for preparing the traditional Chinese medicine spray for treating allergic rhinitis as described in claim 1, characterized in that, In step (2), both the first and second distillation processes are carried out at 100-110℃.

9. A traditional Chinese medicine spray for treating allergic rhinitis obtained by any one of the preparation methods described in claims 1 to 8.