Traditional Chinese medicine compound composition for treating pulmonary nodules
By combining Chinese medicinal herbs such as cat's claw grass to form a multi-target synergistic Chinese medicine compound, the problems of low specificity and high radiation risk in the diagnosis and treatment of pulmonary nodules have been solved, providing a safe, effective and economical treatment plan that is suitable for use in primary healthcare institutions.
Patent Information
- Application Number
- CN202511213775.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-28
- Publication Date
- 2025-11-11
AI Technical Summary
Existing technologies for the diagnosis and treatment of pulmonary nodules suffer from low diagnostic specificity, high risk of radiation exposure, and limitations in treatment methods. Traditional Chinese medicine intervention programs need further optimization to meet multiple requirements of safety, effectiveness, and cost-effectiveness.
This formula combines Chinese medicinal herbs such as cat's claw grass and white flower tongue grass to form a multi-target synergistic compound. The herbs are decocted separately to avoid mutual interference and ensure the release of effective ingredients. The preparation method is simple and easy to implement, making it suitable for use in primary healthcare institutions.
It improves the microenvironment of pulmonary nodules, delays the onset of lung cancer, increases the extraction rate of effective components, reduces costs, and provides a safe and convenient treatment option.
Smart Images
Figure CN120919255A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically referring to a traditional Chinese medicine compound composition for treating pulmonary nodules. Background Technology
[0002] With the rapid development of medical imaging technology, low-dose computed tomography (LDCT) has become an important means of screening for lung diseases, showing significant advantages in detecting pulmonary nodules. However, LDCT has low diagnostic specificity for the nature of pulmonary nodules, and long-term follow-up may increase the risk of radiation exposure. Lung cancer is the malignant tumor with the highest incidence and mortality rate in my country, with 978,000 new cases in 2021. Early manifestations of pulmonary nodules are often small and closely related to the development of lung cancer. Currently, clinical management of pulmonary nodules relies mainly on follow-up examinations after anti-inflammatory treatment, surgery, or long-term CT follow-up, but these methods have certain limitations in early qualitative diagnosis and effective medical intervention.
[0003] Traditional Chinese medicine (TCM) has demonstrated unique advantages in chronic disease management and early intervention, particularly under the guidance of the "disease-body differentiation" principle. Targeting the pathogenesis of pulmonary nodules characterized by "yin-yang imbalance and yin pathogenic factors accumulating," TCM can alleviate symptoms and control the disease through treatment principles that combine strengthening the spleen and eliminating dampness, detoxifying and dispersing nodules with promoting qi and blood circulation. Existing research indicates that TCM compound combinations have potential in regulating the body's immune function, inhibiting inflammatory responses, and improving the microenvironment. However, TCM intervention programs for pulmonary nodules still require further optimization to meet the diverse clinical needs for safety, efficacy, and cost-effectiveness.
[0004] Traditional Chinese medicine herbs such as *Cat's Claw* and *Hedyotis diffusa* are widely used in the treatment of nodular diseases in clinical practice due to their detoxifying, nodule-dispersing, blood-activating, and stasis-removing effects. Through scientific formulation and process optimization, a traditional Chinese medicine compound composition targeting pulmonary nodules can be developed, providing a safe and effective option for early intervention, while also helping to delay the onset of lung cancer and improve patient prognosis. This invention is based on the above needs and aims to provide a traditional Chinese medicine compound composition with clear treatment principles and excellent clinical application prospects. Summary of the Invention
[0005] The purpose of this invention is to provide a traditional Chinese medicine compound composition for treating pulmonary nodules. The interaction of the herbs used in this invention forms a multi-target synergistic therapeutic system, which helps improve the microenvironment of pulmonary nodules and delay the onset of lung cancer. Simultaneously, by decocting raw oysters separately, the full release of their mineral components is ensured. The main medicinal materials and regulators are decocted independently, avoiding interference between different medicinal materials and improving the extraction and utilization rate of effective components. The medicinal materials selected in this invention are all traditional Chinese medicines, with high safety and low cost, suitable for long-term use. Furthermore, by optimizing the preparation process, waste of medicinal materials is reduced, improving economic efficiency. No complex equipment or technology is required, making it suitable for promotion and use in primary healthcare institutions, providing a convenient treatment option for patients with pulmonary nodules.
[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a traditional Chinese medicine compound composition for treating pulmonary nodules.
[0007] The traditional Chinese medicine compound composition includes the following components in parts by weight: 10-30 parts of cat's claw grass, 5-20 parts of white flower tongue grass, 5-50 parts of agrimony, 20-40 parts of raw coix seed, 10-20 parts of vinegar-processed chicken gizzard lining, 10-20 parts of raw oyster shell, 5-15 parts of red peony root, and 1-10 parts of turmeric.
[0008] Preferably, the traditional Chinese medicine compound composition comprises the following components in parts by weight: 15 parts of cat's claw grass, 15 parts of white flower tongue grass, 15 parts of agrimony, 30 parts of raw coix seed, 15 parts of vinegar-processed chicken gizzard lining, 15 parts of raw oyster shell, 10 parts of red peony root, and 5 parts of turmeric.
[0009] Furthermore, the saponin compounds contained in the cat's claw grass and the flavonoid compounds in the white flower snake tongue grass form a complex during the decoction process.
[0010] Furthermore, the polysaccharide components in the raw coix seed undergo an esterification reaction with the organic acids in the vinegar-processed chicken gizzard under weakly acidic conditions to generate small molecule compounds with spleen-strengthening and dampness-removing functions.
[0011] Furthermore, the calcium ions in the raw oyster react with paeoniflorin in the red peony root to form a complex during the decoction process.
[0012] This invention also provides a method for preparing a traditional Chinese medicine compound composition for treating pulmonary nodules, the preparation method comprising the following steps:
[0013] (1) Place 15g of raw oysters in a decoction pot, add 500ml of water, bring to a boil over high heat, then simmer over low heat with the lid off for 30 minutes to fully release the calcium ions and trace elements.
[0014] (2) Add 15g of cat's claw grass, 15g of white flower tongue grass, 15g of agrimony, 30g of raw coix seed, 15g of vinegar chicken gizzard lining, 10g of red peony root, and 5g of turmeric to a clay pot, add water to 500ml, bring to a boil over high heat, then turn to low heat and simmer uncovered for 20 minutes, then filter to obtain the first decoction.
[0015] (3) Add water to the filtered dregs to 500ml, bring to a boil over high heat, then simmer over low heat with the lid off for 20 minutes. Filter to obtain the second decoction.
[0016] (4) Combine the two decoctions to obtain the Chinese herbal compound decoction for treating pulmonary nodules.
[0017] Preferably, the high-temperature heating is 95-100℃ and the low-temperature heating is 60-80℃.
[0018] Preferably, the filter screen used for filtration has a mesh size of 100 to 150.
[0019] The beneficial effects of the present invention using the above structure are as follows: (1) The interaction of Chinese medicines used in the present invention forms a multi-target synergistic treatment system, which helps to improve the microenvironment of pulmonary nodules and delay the onset of lung cancer; (2) The present invention ensures the full release of mineral components by decocting raw oysters separately; the main medicinal materials and regulators are decocted separately to avoid mutual interference between different medicinal materials and improve the extraction rate and utilization rate of effective components; (3) The Chinese medicinal materials selected in the present invention are all traditional Chinese medicines with high safety and low cost, which are suitable for long-term use; at the same time, by optimizing the preparation process, the waste of medicinal materials is reduced and the economic benefits are improved; (4) The preparation method provided by the present invention is simple and easy to implement, without the need for complicated equipment and technology, and is suitable for promotion and use in primary medical institutions, providing a convenient treatment option for patients with pulmonary nodules.
[0020] The traditional Chinese medicines used in this invention work synergistically to maximize their therapeutic effect on pulmonary nodules. Among them, *Cephalotaxus fortunei*, as one of the main components, contains saponins that work synergistically with flavonoids in *Hedyotis diffusa* to regulate the body's immune function and inhibit inflammatory responses. *Agrimonia pilosa*, rich in tannins, further enhances the anti-inflammatory effect and also has certain detoxifying and nodule-dispersing effects. The polysaccharides in raw *Coix lacryma-jobi* and the organic acids in vinegar-processed chicken gizzard lining work together to strengthen the spleen and promote diuresis, facilitating the elimination of dampness from the body. The calcium ions in raw oyster shell and paeoniflorin in *Paeonia lactiflora* work synergistically to improve blood circulation and alleviate blood stasis symptoms. Curcumin in turmeric promotes blood circulation and removes blood stasis, while also possessing antioxidant properties, which help improve the lung microenvironment. Attached Figure Description
[0021] Figure 1 The reduction in the maximum diameter of the nodule.
[0022] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the embodiments of the invention to explain the invention and do not constitute a limitation thereof. Detailed Implementation
[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.
[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those familiar to those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to this invention. The preferred embodiments and materials described herein are for illustrative purposes only and do not limit the scope of this application.
[0025] Unless otherwise specified, the experimental methods used in the following examples are conventional methods; unless otherwise specified, the experimental materials and test strains used in the following examples were purchased from commercial channels.
[0026] Example 1
[0027] A traditional Chinese medicine compound composition for treating pulmonary nodules
[0028] The traditional Chinese medicine compound composition includes the following components in parts by weight: 10 parts of cat's claw grass, 20 parts of white flower tongue grass, 5 parts of agrimony, 40 parts of raw coix seed, 10 parts of vinegar-processed chicken gizzard lining, 20 parts of raw oyster shell, 5 parts of red peony root, and 10 parts of turmeric.
[0029] The saponin compounds contained in the cat's claw grass form a complex with the flavonoid compounds in the white flower snake tongue grass during the decoction process.
[0030] In this process, the polysaccharide components in raw coix seed undergo an esterification reaction with the organic acids in vinegar-processed chicken gizzard under weakly acidic conditions to generate small molecule compounds with spleen-strengthening and dampness-removing functions.
[0031] In this process, the calcium ions in the raw oyster react with paeoniflorin in the red peony root to form a complex.
[0032] This invention also provides a method for preparing a traditional Chinese medicine compound composition for treating pulmonary nodules, the preparation method comprising the following steps:
[0033] (1) Place 15g of raw oysters in a decoction pot, add 500ml of water, bring to a boil over high heat, then simmer over low heat with the lid off for 30 minutes to fully release the calcium ions and trace elements.
[0034] (2) Add 15g of cat's claw grass, 15g of white flower tongue grass, 15g of agrimony, 30g of raw coix seed, 15g of vinegar chicken gizzard lining, 10g of red peony root, and 5g of turmeric to a clay pot, add water to 500ml, bring to a boil over high heat, then turn to low heat and simmer uncovered for 20 minutes, then filter to obtain the first decoction.
[0035] (3) Add water to the filtered dregs to 500ml, bring to a boil over high heat, then simmer over low heat with the lid off for 20 minutes. Filter to obtain the second decoction.
[0036] (4) Combine the two decoctions to obtain the Chinese herbal compound decoction for treating pulmonary nodules.
[0037] The high-temperature setting is 95–100℃, and the low-temperature setting is 60–80℃.
[0038] The filter used in the filtration process has a mesh size of 100 to 150.
[0039] Example 2
[0040] A traditional Chinese medicine compound composition for treating pulmonary nodules.
[0041] The traditional Chinese medicine compound composition includes the following components in parts by weight: 30 parts of cat's claw grass, 5 parts of white flower tongue grass, 50 parts of agrimony, 20 parts of raw coix seed, 20 parts of vinegar-processed chicken gizzard lining, 10 parts of raw oyster shell, 15 parts of red peony root, and 1 part of turmeric.
[0042] The saponin compounds contained in the cat's claw grass form a complex with the flavonoid compounds in the white flower snake tongue grass during the decoction process.
[0043] In this process, the polysaccharide components in raw coix seed undergo an esterification reaction with the organic acids in vinegar-processed chicken gizzard under weakly acidic conditions to generate small molecule compounds with spleen-strengthening and dampness-removing functions.
[0044] In this process, the calcium ions in the raw oyster react with paeoniflorin in the red peony root to form a complex.
[0045] The present invention also provides a method for preparing a traditional Chinese medicine compound composition for treating pulmonary nodules, wherein the preparation method is performed in accordance with Example 1.
[0046] Example 3
[0047] A traditional Chinese medicine compound composition for treating pulmonary nodules.
[0048] The traditional Chinese medicine compound composition includes the following components in parts by weight: 15 parts of cat's claw grass, 15 parts of white flower tongue grass, 15 parts of agrimony, 30 parts of raw coix seed, 15 parts of vinegar-processed chicken gizzard lining, 15 parts of raw oyster shell, 10 parts of red peony root, and 5 parts of turmeric.
[0049] The saponin compounds contained in the cat's claw grass form a complex with the flavonoid compounds in the white flower snake tongue grass during the decoction process.
[0050] In this process, the polysaccharide components in raw coix seed undergo an esterification reaction with the organic acids in vinegar-processed chicken gizzard under weakly acidic conditions to generate small molecule compounds with spleen-strengthening and dampness-removing functions.
[0051] In this process, the calcium ions in the raw oyster react with paeoniflorin in the red peony root to form a complex.
[0052] The present invention also provides a method for preparing a traditional Chinese medicine compound composition for treating pulmonary nodules, wherein the preparation method is performed in accordance with Example 1.
[0053] Experimental Example 1
[0054] 1. Subjects: Forty patients with pulmonary nodules who recently visited the hospital were selected and randomly divided into four groups: Example 1 group, Example 2 group, Example 3 group, and control group. All subjects met the following criteria:
[0055] (1) Diagnosed by chest CT as small pulmonary nodules (5-10 mm in diameter), including ground-glass nodules and mixed density nodules;
[0056] (2) Complete the SHOX2 / RASSF1A / PTGER4ctDNA methylation detection and 7 tests for lung cancer autoantibodies;
[0057] (3) No severe liver or kidney dysfunction, autoimmune diseases, and no other treatment for pulmonary nodules in the past 3 months;
[0058] (4) Voluntarily participate in the trial and sign the informed consent form.
[0059] 2. Experimental Methods: Patients in each group took the traditional Chinese medicine compound decoction prepared according to the methods described in Examples 1-3, while the control group took a commercially available traditional Chinese medicine compound decoction. One dose was taken daily, divided into two warm doses, morning and evening, for 12 consecutive weeks. During this period, other medications that might affect the efficacy were avoided. Chest CT scans were performed before and after the experiment to measure the maximum diameter of the nodules, and the average reduction in nodule diameter was calculated for each group.
[0060] 3. Results Analysis: For example... Figure 1 As shown, the maximum diameter of nodules in each group decreased before and after the experiment, with the largest decrease observed in the group of Example 3.
[0061] Experimental Example 2
[0062] Mr. Lin, male, 33 years old, had a history of pulmonary nodules for over a year. A chest CT scan in June 2024 showed a single ground-glass nodule in the upper lobe of the right lung, approximately 8*7mm. SHOX2 / RASSF1A / PTGER4 ctDNA methylation test: 2.87. Seven lung cancer autoantibodies were tested: P53: 0.2; PGP: 0.3; SOX2: 0.3; GAGE7: 0.5; GBU4-5: 0.3; MAGEA1: 0.3; CAGE: 0.3. He had taken the medication described in this invention... The decoction prepared in Example 3 was tested after 12 weeks. SHOX2 / RASSF1A / PTGER4ctDNA methylation was 0.53. Seven lung cancer autoantibodies were tested: P53: 0.1; PGP: 0.1; SOX2: 0.1; GAGE7: 0.3; GBU4-5: 0.1; MAGEA1: 0.3; CAGE: 0.3. A follow-up chest CT scan in December 2024 showed that the ground-glass nodule in the upper lobe of the right lung had slightly decreased in size, with a maximum diameter of approximately 4 mm.
[0063] Experimental Example 3
[0064] Mr. Guo, male, 64 years old, had a history of pulmonary nodules for more than 3 years. A chest CT scan in January 2024 showed a mixed density nodule in the lower lobe of his left lung, approximately 10 mm in size. SHOX2 / RASSF1A / PTGER4 ctDNA methylation test: 2.37. Seven lung cancer autoantibodies were tested: P53: 0.4; PGP: 0.2; SOX2: 0.2; GAGE7: 3; GBU4-5: 4.7; MAGEA1: 0.1; CAGE: 0.1. He had taken the above-mentioned... The decoction prepared in Example 3 was examined after 12 weeks. SHOX2 / RASSF1A / PTGER4 ctDNA methylation test showed a result of 0.79. The results for the seven lung cancer autoantibodies were as follows: P53: 0.4; PGP: 0.1; SOX2: 0.2; GAGE7: 1.3; GBU4-5: 4.1; MAGEA1: 0.1; CAGE: 0.1. A follow-up chest CT scan in November 2024 showed that the ground-glass nodule in the lower lobe of the left lung had slightly decreased in size, with a maximum diameter of approximately 7 mm.
[0065] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.
[0066] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the invention, such designs should fall within the protection scope of the present invention.
Claims
1. A traditional Chinese medicine compound composition for treating pulmonary nodules, characterized in that: The traditional Chinese medicine compound composition includes the following components in parts by weight: 10-30 parts of cat's claw grass, 5-20 parts of white flower tongue grass, 5-50 parts of agrimony, 20-40 parts of raw coix seed, 10-20 parts of vinegar-processed chicken gizzard lining, 10-20 parts of raw oyster shell, 5-15 parts of red peony root, and 1-10 parts of turmeric.
2. The traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 1, characterized in that: The traditional Chinese medicine compound composition includes the following components in parts by weight: 15 parts of cat's claw grass, 15 parts of white flower tongue grass, 15 parts of agrimony, 30 parts of raw coix seed, 15 parts of vinegar-processed chicken gizzard lining, 15 parts of raw oyster shell, 10 parts of red peony root, and 5 parts of turmeric.
3. The traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 2, characterized in that: The saponins in the cat's claw grass and the flavonoids in the white flower snake tongue grass form a complex during the decoction process.
4. The traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 3, characterized in that: The polysaccharide components in raw coix seed undergo esterification with the organic acids in vinegar-processed chicken gizzard under weakly acidic conditions to generate small molecule compounds with spleen-strengthening and dampness-removing functions.
5. The traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 4, characterized in that: The calcium ions in the raw oyster react with paeoniflorin in the red peony root to form a complex during the decoction process.
6. A method for preparing a traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 5, characterized in that: The preparation method includes the following steps: (1) Place 15g of raw oysters in a decoction pot, add 500ml of water, bring to a boil over high heat, then simmer over low heat with the lid off for 30 minutes to fully release the calcium ions and trace elements. (2) Add 15g of cat's claw grass, 15g of white flower tongue grass, 15g of agrimony, 30g of raw coix seed, 15g of vinegar chicken gizzard lining, 10g of red peony root, and 5g of turmeric to a clay pot, add water to 500ml, bring to a boil over high heat, then turn to low heat and simmer uncovered for 20 minutes, then filter to obtain the first decoction. (3) Add water to the filtered dregs to 500ml, bring to a boil over high heat, then simmer over low heat with the lid off for 20 minutes. Filter to obtain the second decoction. (4) Combine the two decoctions to obtain the Chinese herbal compound decoction for treating pulmonary nodules.
7. A traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 6, characterized in that: The high-temperature setting is 95–100℃, and the low-temperature setting is 60–80℃.
8. A traditional Chinese medicine compound composition for treating pulmonary nodules according to claim 7, characterized in that: The filter used in the filtration process has a mesh size of 100 to 150.