Traditional Chinese medicine composition for treating exogenous fever caused by virus and bacterial infection and preparation method thereof

Abstract

A traditional Chinese medicine composition for treating exogenous fever caused by virus and bacterial infection belongs to the technical field of traditional Chinese medicine preparation, and is prepared from the following raw materials: platycodon grandiflorum, fructus forsythiae, gypsum, almond, ephedra, cassia twig, radix puerariae, radix bupleuri, codonopsis pilosula, pinellia ternate, bighead atractylodes rhizome, poria cocos, parched white peony root, rhizoma alismatis, polyporus umbellatus, liquorice, ginger, red dates and rice. The ephedra, apricot kernel, gypsum and liquorice granules comprise gypsum, apricot kernel, ephedra and liquorice; the kudzuvine root granules comprise kudzuvine roots, ephedra, cassia twigs, parched white peony roots, liquorice, fresh ginger and red dates; the common goldenrop particles comprise bupleurum, codonopsis pilosula, pinellia ternate, liquorice, ginger and red dates; the five-poria granules comprise bighead atractylodes rhizome, poria cocos, rhizoma alismatis, cassia twig and grifola. The preparation method of the traditional Chinese medicine composition for treating exogenous fever caused by virus and bacterial infection comprises eight steps. According to the invention, sequelae are blocked from the root of pathogenesis, the course of disease is shortened, and repeated treatment cost can be avoided; the method is suitable for rapidly controlling large-scale infectious diseases and relieving medical squeezing.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine formulation and processing technology, and in particular to a traditional Chinese medicine composition and preparation method for treating exogenous fever caused by viral and bacterial infections. Background Technology

[0002] "External invasion" as a Chinese term specifically refers to diseases caused by external pathogens such as wind, cold, summer heat, and dampness invading the human body. Its pathogenic mechanism includes the invasion of the six external pathogens (wind, cold, summer heat, dampness, dryness, and fire) and pestilential qi (infectious pathogens) through the body surface or mouth and nose. Typical symptoms include chills, fever, headache, body aches, and other superficial symptoms.

[0003] Currently, Western medicine is generally used to treat fever caused by external pathogens. While Western medicine has certain advantages, it also has the following technical disadvantages due to technological limitations: (1) Western antipyretics can easily cause patients to sweat profusely or not sweat after taking the medication, or the body temperature may rise again after the temperature drops, with the interval being less than 4 hours; (2) After the fever is reduced, sequelae such as cough, asthma, palpitations, and fatigue often occur; (3) The condition recurs frequently, and the existing treatment plans are not effective for infectious diseases such as influenza A, COVID-19, rhinovirus, and bacteria. In summary, Western medicine only treats the symptoms of fever and does not address the core pathogenesis of "external stagnation of pathogenic factors and disharmony of Ying and Wei" in traditional Chinese medicine, and therefore cannot fundamentally treat the disease. Summary of the Invention

[0004] In order to overcome the shortcomings of existing Western medicines for treating exogenous febrile diseases due to technological limitations, as described in the background art, this invention provides a traditional Chinese medicine composition and preparation method for treating exogenous febrile diseases caused by viral and bacterial infections. Under the combined effect of relevant formulations and preparation processes, different formulations can effectively solve the problems of persistent high fever (>38.5℃) or fever without sweating after oral antipyretics, shorten the fever reduction time, and reduce sequelae symptoms such as cough and fatigue.

[0005] The technical solution adopted by this invention to solve its technical problem is: This is a traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections. All raw materials used include Platycodon grandiflorus, Forsythia suspensa, Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, Cinnamomum cassia, Pueraria lobata, Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Atractylodes macrocephala, Poria cocos, stir-fried Paeonia lactiflora, Alisma plantago-aquatica, Polyporus umbellatus, Glycyrrhiza uralensis, Zingiber officinale, Ziziphus jujuba, and rice. These medicinal materials are prepared into Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules. The raw materials for Ma Xing Shi Gan Granules include Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, and Glycyrrhiza uralensis. The raw materials for Ge Gen Granules include Pueraria lobata, Ephedra sinica, Cinnamomum cassia, stir-fried Paeonia lactiflora, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba. The raw materials for Xiao Chai Hu Granules include Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba. The raw materials for Wu Ling Granules include Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Cinnamomum cassia, and Polyporus umbellatus.

[0006] Furthermore, the Ma Xing Shi Gan granules, Ge Gen granules, Xiao Chai Hu granules, and Wu Ling granules shall be supplemented with Platycodon grandiflorus and Forsythia suspensa, respectively.

[0007] Furthermore, the proportions of all the ingredients are as follows: Platycodon grandiflorus 7g-9g, Forsythia suspensa 10g-11g, Gypsum fibrosum 14g-16g, Prunus armeniaca 9g-11g, Ephedra sinica 2g-4g, Cinnamomum cassia 2g-4g, Pueraria lobata 44g-46g, Bupleurum chinense 4g-6g, Codonopsis pilosula 9g-11g, Pinellia ternata 5g-7g, Atractylodes macrocephala 14g-16g, Poria cocos 14g-16g, Paeonia lactiflora (fried) 14g-16g, Alisma plantago-aquatica 11g-13g, Polyporus umbellatus 9g-11g, Glycyrrhiza uralensis 5g-7g, fresh ginger 4-6 slices, red dates 5-6 pieces, and rice 90g-110g.

[0008] Furthermore, the kudzu root granules have the functions of relieving exterior symptoms, clearing the lungs, and harmonizing the Ying and Wei Qi; the ephedra, apricot kernel, licorice, and ginseng granules and the five-ingredient granules have the functions of clearing heat and promoting diuresis; and the small bupleurum granules have the functions of harmonizing the Shao Yang, regulating the liver and stomach, blocking the internal transmission of pathogenic factors, and restoring the balance of Qi.

[0009] A method for preparing a traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections includes the following steps: decocting multiple raw materials separately, decocting multiple raw materials together, primary concentration, secondary concentration, spray drying, preparing into granules, and packaging the finished product.

[0010] Furthermore, the containers used in the soaking and moistening of various raw materials, the separate decoction of various raw materials, and the mixed decoction of various raw materials are made of stainless steel and are heated slowly.

[0011] Furthermore, the finished products packaged are, respectively, Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules.

[0012] Furthermore, the primary concentration, secondary concentration, and spray drying are performed under vacuum conditions.

[0013] Compared with existing technologies, this invention has the following significant advantages: It overcomes the bottleneck of ineffective antipyretics in Western medicine. Ge Gen granules relieve exterior symptoms, promote lung function, and harmonize the Ying and Wei Qi; Ma Xing Shi Gan granules and Wu Ling granules clear heat and promote diuresis (clearing heat, expelling pathogens through urination); Xiao Chai Hu granules harmonize Shao Yang, regulate the liver and stomach, block the internal transmission of pathogens, and restore Qi balance. It addresses the root cause of the disease, preventing sequelae and shortening the course of illness, thus avoiding repeated medical visits or the cost of treating sequelae (such as the need for additional antibiotics or nebulization for persistent cough). It is suitable for the rapid control of large-scale infectious diseases (such as influenza and COVID-19), alleviating the strain on medical resources. In summary, this invention has promising application prospects. Attached Figure Description

[0014] Figure 1This is a schematic diagram of the preparation method of the traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to the present invention. Detailed Implementation

[0015] This is a traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections. All raw materials used include Platycodon grandiflorus, Forsythia suspensa, Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, Cinnamomum cassia, Pueraria lobata, Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Atractylodes macrocephala, Poria cocos, stir-fried Paeonia lactiflora, Alisma plantago-aquatica, Polyporus umbellatus, Glycyrrhiza uralensis, Zingiber officinale, Ziziphus jujuba, and rice. These herbs are prepared into Ma Xing Shi Gan Granules, Pueraria lobata Granules, Xiao Chai Hu Granules, and Wu Ling Granules (or decoctions). The raw materials for Ma Xing Shi Gan Granules include Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, and Glycyrrhiza uralensis; the raw materials for Pueraria lobata Granules include Pueraria lobata, Ephedra sinica, Cinnamomum cassia, stir-fried Paeonia lactiflora, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba; the raw materials for Xiao Chai Hu Granules include Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba; and the raw materials for Wu Ling Granules include Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Cinnamomum cassia, and Polyporus umbellatus. Platycodon grandiflorus and Forsythia suspensa are added to Ma Xing Shi Gan Granules, Pueraria lob All ingredients, in Example 1: Platycodon grandiflorus 8g, Forsythia suspensa 10g, Gypsum fibrosum 15g, Prunus armeniaca 10g, Ephedra sinica 3g, Cinnamomum cassia 3g, Pueraria lobata 45g, Bupleurum chinense 5g, Codonopsis pilosula 10g, Pinellia ternata 6g, Atractylodes macrocephala 15g, Poria cocos 15g, Paeonia lactiflora (fried) 15g, Alisma plantago-aquatica 12g, Polyporus umbellatus 10g, Glycyrrhiza uralensis 6g, fresh ginger 5 slices, jujubes 5 pieces, rice 100g (to harmonize the medicinal properties and protect the stomach and promote the production of body fluids). In Example 2: Platycodon grandiflorus 9g, Forsythia suspensa 11g, Gypsum fibrosum 14g, Prunus armeniaca 11g, Ephedra sinica 4g, Cinnamomum cassia 2g, Pueraria lobata 44g, Bupleurum chinense 6g, Codonopsis pilosula 11g, Pinellia ternata 5g, Atractylodes macrocephala 16g, Poria cocos 14g, Paeonia lactiflora (fried) 14g, Alisma plantago-aquatica 13g, Polyporus umbellatus 11g, Glycyrrhiza uralensis 5g, fresh ginger 6 slices, jujubes 5 pieces, rice 110g. Ge Gen Granules have the effects of relieving exterior symptoms, clearing the lungs, and harmonizing Ying and Wei; Ma Xing Shi Gan Granules and Wu Ling Granules have the effects of clearing heat and promoting diuresis; Xiao Chai Hu Granules have the effects of harmonizing Shao Yang, regulating the liver and stomach, blocking the internal transmission of pathogenic factors, and restoring the balance of Qi.

[0016] Figure 1 As shown, the preparation method of a traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections includes the following steps: soaking and moistening various raw materials separately, decocting various raw materials individually, decocting various raw materials together, primary concentration, secondary concentration, spray drying, granulation and drying, and packaging the finished product. The containers used for soaking and moistening various raw materials, decocting various raw materials individually, and decocting various raw materials together are made of stainless steel, and slow heating is employed. The packaged finished products are Ma Xing Shi Gan granules, Ge Gen granules, Xiao Chai Hu granules, and Wu Ling granules. The primary concentration, secondary concentration, and spray drying are performed under vacuum conditions.

[0017] The clinical data of this invention are as follows: (1) Through clinical observation of 200 patients with high fever caused by viral or bacterial infection (including 180 adults and 20 children), Chai Ling antipyretic granules (Xiao Chai Hu granules and Wu Ling granules) showed significant advantages. Specifically, for those who took the medicine before noon (before 12:00): 92.6% of the patients had their body temperature return to normal (below 37.2℃) the next morning. Sequelae control: the incidence of cough in patients decreased from 68% in the Western medicine group to 12%; the incidence of fatigue decreased from 75% in the Western medicine group to 9%; and the incidence of palpitations / asthma symptoms decreased by more than 85%. Applicable population: effective rate in adults: 96.4% (192 / 200 cases); effective rate in children: 94.0% (94 / 100 cases), and no drug refusal reaction. It covers children over 3 years old and the elderly (maximum age 82 years old), and there is no age difference in safety. (2) Scientific analysis of technical effects: This invention breaks through the bottleneck of the ineffectiveness of Western medicine in reducing fever. Traditional antipyretics (such as ibuprofen) forcefully reduce fever by inhibiting prostaglandin synthesis, but cannot solve the core pathogenesis of "evil stagnation on the skin surface" in traditional Chinese medicine. This solution achieves "sweating and fever reduction without leaving evil" by using Ephedra Granules (corresponding to Ephedra, Apricot Kernel, Glycyrrhiza Granules, Pueraria Granules, Bupleurum Granules, or Five-Ingredient Rehmannia Granules) + Cinnamon Twig Decoction (corresponding to Ephedra, Apricot Kernel, Glycyrrhiza Granules, Bupleurum Granules, or Five-Ingredient Rehmannia Granules, which relieves exterior symptoms and induces sweating), Five-Ingredient Rehmannia Granules + Ephedra, Apricot Kernel, Glycyrrhiza Granules (clearing heat and promoting diuresis) and Bupleurum Granules, thus solving the clinical problem of "profuse sweating without fever reduction" or "no sweating without fever reduction" caused by Western medicine.

[0018] (3) This invention can block sequelae from the root of the disease mechanism. The specific sequelae of exogenous disease (cough, fatigue) are caused by "weak lung and defensive qi and depletion of body fluids" after fever. Xiao Chai Hu Tang can harmonize Shao Yang and prevent the internal transmission of pathogenic factors; ginger, jujube and rice can nourish the spleen and stomach and restore the generation of body fluids; Wu Ling San can promote diuresis and eliminate dampness, so that pathogenic factors are expelled through urination and phlegm and fluid retention are prevented from being generated internally.

[0019] (4) Social and economic benefits: This invention can shorten the course of disease, reduce medical expenses, and avoid repeated visits or costs for sequelae treatment (such as the need for additional antibiotics or nebulization for persistent cough); its public health value is reflected in its applicability to the rapid control of large-scale infectious diseases (such as influenza and COVID-19) and its ability to alleviate medical pressure. Typical Cases of this Invention (Supplementary Evidence) Case 1 (Adult, Viral Infection): Medical History: Fever lasting for 2 days, with a highest temperature of 39.5℃. After oral ibuprofen treatment, the body temperature decreased after sweating, but rose again after 4 hours, and the recurrence was repeated. The patient sought medical attention that morning and was instructed to take one dose of this invention (Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules, specifically containing ginger, jujube, and rice) before 12:00 noon. The body temperature stabilized at 36.7℃ after 10:00 the next day. Case 2 (Child, COVID-19 Infection): Medical History: Fever for 1 day, no sweating, with a highest temperature of 38.9℃, dry and cracked lips, nasal congestion and runny nose, sore throat, poor appetite. Western antipyretics were ineffective. The patient was instructed to take one dose of this invention (Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules, containing ginger, jujube, and rice) before 12:00 noon, 100ml each time, every 3 hours, and drink thin porridge after each dose. The patient sweated slightly at night. The appetite returned the next morning, and the body temperature stabilized at 36.7℃. This invention, through multi-target synergistic action, significantly outperforms existing technologies in terms of fever reduction speed, prevention of sequelae, and safety, and exhibits a clear dose-response relationship (ginger, jujube, and rice porridge is a key synergistic factor). Clinical data support its value as a first-line antipyretic traditional Chinese medicine preparation. Representative Example 1 of this Invention: Preparation and Clinical Application of Antipyretic Compound (Adult Viral Fever Case); Case Background: Patient: Male, 35 years old, diagnosed with influenza A virus infection. Symptoms: High fever of 39.5℃ for 3 days, profuse sweating after oral ibuprofen but fever persists (repeatedly above 39℃), accompanied by headache, muscle aches, anhidrosis, red tongue with thin yellow coating, and floating and rapid pulse. Western Medicine Diagnosis: Influenza virus infection; Traditional Chinese Medicine Differentiation: Wind-cold binding the exterior, stagnation transforming into heat, combined with dysfunction of the Shaoyang meridian. The method of medication and dynamic effect observation are shown in the table below.

[0020] The key technological innovations of this invention are reflected in the following aspects: Static relationship and herbal compatibility: Ephedra and gypsum are used in a combination of warming and cooling properties, inducing sweating while preventing excessive sweating and fluid depletion; Bupleurum and Scutellaria form a core herbal pair for "harmonizing the Lesser Yang." Excipient role: Rice, ginger, and jujube form a "food and medicine homology" protective layer, protecting the stomach and promoting fluid production. Dynamic relationship and stepwise fever reduction: Firstly, it conforms to the TCM theory of "sweating-clearing-harmonizing" for fever reduction. Prevention of sequelae: Xiao Chai Hu Tang blocks the transmission of pathogenic factors to the Lesser Yang, and Wu Ling San prevents the internal generation of phlegm and fluid retention, interrupting the development of the disease chain. In summary, this embodiment fully demonstrates the entire process of the antipyretic compound from preparation to clinical efficacy. Through the dynamic action of the three stages of "relieving exterior symptoms-clearing heat-harmonizing," it achieves rapid fever reduction without sequelae, verifying the operability and superiority of this invention.

[0021] The single effects of various drugs in this invention are as follows: Platycodon grandiflorus has the effects of relieving throat discomfort, aiding breathing, dissolving phlegm, and eliminating abscesses; Forsythia suspensa has the effects of clearing internal heat toxins, relieving swelling, and dissipating lumps; Gypsum fibrosum has the effects of clearing heat and purging fire, relieving irritability and quenching thirst; Prunus armeniaca has the effects of antioxidation, regulating blood lipids, and moistening the intestines and promoting bowel movements; Ephedra sinica has the effects of inducing sweating and relieving exterior syndromes, promoting lung function and relieving asthma, and promoting diuresis and reducing swelling; Cinnamomum cassia has the effects of inducing sweating and relieving exterior syndromes, harmonizing the body's defenses, and promoting lung function and relieving asthma; Pueraria lobata has the effects of inducing sweating and relieving exterior syndromes, and relaxing muscles and tendons; Bupleurum chinense has the effects of detoxifying... It has the effects of dispelling cold, harmonizing the lesser yang, and regulating qi; Codonopsis pilosula has the effects of tonifying the middle energizer and replenishing qi, quenching thirst, strengthening the spleen and benefiting the lungs, nourishing blood and promoting body fluids; Pinellia ternata has the effects of inducing sweating and relieving exterior syndromes, clearing the lungs and relieving asthma, and promoting diuresis and reducing swelling; Atractylodes macrocephala has the effects of strengthening the spleen and drying dampness, and stopping sweating; Poria cocos has the effects of promoting diuresis and removing dampness, strengthening the spleen and stomach, nourishing the heart and calming the mind; stir-fried Paeonia lactiflora has the effects of nourishing blood and regulating menstruation, softening the liver and relieving pain, and astringing yin and stopping sweating; Alisma plantago-aquatica has the effects of promoting diuresis and removing dampness, clearing heat, resolving turbidity and lowering lipids; Polyporus umbellatus has the effects of promoting diuresis and reducing swelling, and removing dampness; Glycyrrhiza uralensis has the effects of tonifying qi and moistening the lungs, relieving cough and resolving phlegm, and detoxifying and relieving pain; Ginger has the effects of dispelling cold and warming the body, anti-oxidation, and promoting digestion; Jujube has the effects of tonifying qi and nourishing blood, improving digestion, and calming the mind and aiding sleep.

[0022] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0023] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections, characterized in that, The raw materials used include Platycodon grandiflorus, Forsythia suspensa, Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, Cinnamomum cassia, Pueraria lobata, Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Atractylodes macrocephala, Poria cocos, stir-fried Paeonia lactiflora, Alisma plantago-aquatica, Polyporus umbellatus, Glycyrrhiza uralensis, Zingiber officinale, Ziziphus jujuba, and rice. These medicinal materials are respectively prepared into Ma Xing Shi Gan Granules, Pueraria lobata Granules, Xiao Chai Hu Granules, and Wu Ling Granules. The raw materials of Ma Xing Shi Gan Granules include Gypsum fibrosum, Prunus armeniaca, Ephedra sinica, and Glycyrrhiza uralensis. The raw materials of Pueraria lobata Granules include Pueraria lobata, Ephedra sinica, Cinnamomum cassia, stir-fried Paeonia lactiflora, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba. The raw materials of Xiao Chai Hu Granules include Bupleurum chinense, Codonopsis pilosula, Pinellia ternata, Glycyrrhiza uralensis, Zingiber officinale, and Ziziphus jujuba. The raw materials of Wu Ling Granules include Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Cinnamomum cassia, and Polyporus umbellatus.

2. The traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to claim 1, characterized in that, Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules should each contain Platycodon grandiflorus and Forsythia suspensa.

3. The traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to claim 1, characterized in that, The proportions of all ingredients are as follows: Platycodon grandiflorus 7g-9g, Forsythia suspensa 10g-11g, Gypsum fibrosum 14g-16g, Prunus armeniaca 9g-11g, Ephedra sinica 2g-4g, Cinnamomum cassia 2g-4g, Pueraria lobata 44g-46g, Bupleurum chinense 4g-6g, Codonopsis pilosula 9g-11g, Pinellia ternata 5g-7g, Atractylodes macrocephala 14g-16g, Poria cocos 14g-16g, Paeonia lactiflora (fried) 14g-16g, Alisma plantago-aquatica 11g-13g, Polyporus umbellatus 9g-11g, Glycyrrhiza uralensis 5g-7g, fresh ginger 4-6 slices, red dates 5-6 pieces, rice 90g-110g.

4. The traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to claim 1, characterized in that, Ge Gen Granules have the effects of relieving exterior symptoms, clearing the lungs, and harmonizing Ying and Wei; Ma Xing Shi Gan Granules and Wu Ling Granules have the effects of clearing heat and promoting diuresis; Xiao Chai Hu Granules have the effects of harmonizing Shao Yang, regulating the liver and stomach, blocking the internal transmission of pathogenic factors, and restoring the balance of Qi.

5. The method for preparing the traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to any one of claims 1 to 4, characterized in that, The process includes the following steps: soaking and moistening various raw materials separately, decocting various raw materials individually, decocting various raw materials together, primary concentration, secondary concentration, spray drying, granulation, and packaging the finished product.

6. The method for preparing the traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to any one of claims 5, characterized in that, The containers used for soaking and moistening various raw materials, decocting various raw materials separately, and decocting various raw materials together are made of stainless steel and are heated slowly.

7. The method for preparing the traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to any one of claims 5, characterized in that, The packaged finished products are Ma Xing Shi Gan Granules, Ge Gen Granules, Xiao Chai Hu Granules, and Wu Ling Granules.

8. The method for preparing the traditional Chinese medicine composition for treating exogenous fever caused by viral and bacterial infections according to any one of claims 5, characterized in that, Primary concentration, secondary concentration, and spray drying are all performed in a vacuum environment.

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