Visual puncture needle assembly and system for stem cell injection

Abstract

The invention discloses a visual puncture needle assembly and system for stem cell injection, and belongs to the technical field of stem cell treatment surgical instruments. The visual puncture needle system comprises a visual puncture needle assembly and an acquisition and display system, the visual puncture needle assembly comprises a puncture needle, a visual sleeve, a plurality of camera probes and a plurality of laser ranging probes, and the acquisition and display system is in communication connection with the camera probes and the laser ranging probes. The collection and display system is used for obtaining internal image picture information of the focus sac cavity and displaying the internal image picture of the focus sac cavity, the internal condition of the focus sac cavity can be observed, the position of the laser ranging probe in the focus sac cavity can be adjusted in an auxiliary mode, and the collection and display system is further used for obtaining internal size information of the focus sac cavity and displaying the internal size information of the focus sac cavity. And the volume of the focus sac cavity is calculated according to the internal size information of the focus sac cavity, so that the dosage of stem cell injection is obtained, and the purpose of precise treatment is achieved.

Description

Technical Field

[0001] This invention relates to the field of surgical instruments for stem cell therapy, and in particular to a visualized puncture needle assembly and system for stem cell injection. Background Technology

[0002] Spinal cord injury and brain injury severely impact patients' quality of life, and traditional treatments have limited effectiveness. Stem cell therapy, as an emerging treatment approach, offers new hope for patients with spinal cord and brain injuries. Stem cell therapy has achieved certain results in preclinical research and some clinical trials, demonstrating great potential, such as promoting nerve regeneration and improving the local microenvironment. However, in practical clinical applications, accurately and effectively implanting stem cells into the lesion cavity (target area) remains a challenge.

[0003] Currently, the common method for implanting stem cells into the lesion cavity is through vertebral or craniotomy. However, vertebral or craniotomy involves large incisions, significant bleeding, and postoperative discomfort. Moreover, the procedure is complex and the surgery is difficult. Summary of the Invention

[0004] One of the objectives of this invention is to provide a visualized puncture needle assembly and system for stem cell injection, addressing the limitations of existing technologies. This allows for the injection of medication into the lesion cavity under local anesthesia, resulting in a smaller surgical wound, less bleeding for the patient, and less postoperative discomfort.

[0005] The second objective of this invention is to provide a visual puncture needle assembly and system for stem cell injection, addressing the current state of the technology. This system uses a camera probe to acquire internal images of the lesion cavity, and then displays these images through a display system. This not only allows observation of the internal condition of the lesion cavity but also assists in adjusting the position of the laser ranging probe within the lesion cavity.

[0006] The third objective of this invention is to provide a visualized puncture needle assembly and system for stem cell injection, addressing the current state of existing technology. Based on multiple sets of data detected by a laser ranging probe, the acquisition and display system can fit the lesion cavity into an ellipsoid and calculate the volume of the lesion cavity, thereby determining the dosage of stem cell injection and achieving the goal of precise treatment.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: A visualization puncture needle assembly for stem cell injection includes: A puncture needle, comprising a puncture needle core and a puncture needle sleeve, is used to construct a channel from outside the body to the lesion cavity; A visualization sleeve, the outer diameter of which is adapted to the inner diameter of the puncture needle sleeve, and a first limiter connected thereto on the visualization sleeve, and the first limiter can move along the axial direction of the visualization sleeve. Several camera probes are located at the front end of the visualization sleeve to collect internal image information of the lesion cavity; Several laser ranging probes are located at the front end of the visualization sleeve to detect the internal dimensions of the lesion cyst.

[0008] Furthermore, it also includes: A limiting injection needle includes a needle and a needle tube. The needle is fixed to one end of the needle tube and communicates with it. The outer diameter of the needle is adapted to the inner diameter of the visualization sleeve. A syringe connector is provided at one end of the needle tube away from the needle. A second limiter is provided on the needle tube and is connected to it. The second limiter can move along the axial direction of the needle tube.

[0009] Furthermore, it also includes: A flushing device, comprising a flushing pipe and a first branch pipe and a second branch pipe, wherein the flushing pipe is a dual-channel pipe, the outer diameter of the flushing pipe is adapted to the inner diameter of the visualization sleeve, and the flushing pipe is made of a soft material, and the first branch pipe and the second branch pipe are respectively connected to the dual channels of the flushing pipe.

[0010] Furthermore, the first limiter and the visual sleeve are connected by a thread.

[0011] Furthermore, the second limiter is threadedly connected to the needle tube.

[0012] Furthermore, the syringe is provided with a limiting scale.

[0013] A visualization puncture needle system for stem cell injection, comprising: The above-mentioned visualized puncture needle components; The acquisition and display system is communicatively connected to several camera probes and several laser ranging probes. The acquisition and display system is used to acquire and display the internal image information of the lesion cyst cavity. The acquisition and display system is also used to acquire the internal size information of the lesion cyst cavity and calculate the volume of the lesion cyst cavity based on the internal size information of the lesion cyst cavity to determine the dosage of stem cell injection.

[0014] Furthermore, the acquisition and display system obtains the internal size information of the lesion cavity, including the following steps: S101. Along the channel from outside the body to the lesion cyst cavity, based on the internal image of the lesion cyst cavity displayed by the acquisition and display system, the visualization sleeve is placed into the target area within the lesion cyst cavity, and then the first limiter is moved to abut against the puncture needle sleeve. S102. Rotate the visualization sleeve. Before rotating the visualization sleeve, the acquisition and display system acquires the straight-line distance D from each laser ranging probe to the corresponding point on the inner wall of the lesion cyst cavity, and obtains a set of data in the internal size information of the lesion cyst cavity. S103. The visualization sleeve is rotated multiple times, and the acquisition and display system acquires multiple sets of data to form the internal size information of the lesion cyst cavity according to S102.

[0015] Furthermore, in step S102, the formula for calculating the straight-line distance D from the laser ranging probe to the corresponding point on the inner wall of the lesion cavity is as follows: D = Bf / x, where B is the baseline distance between the transmitter and receiver in the laser ranging probe, f is the focal length of the optical lens inside the receiver in the laser ranging probe, and x is the offset of the light spot inside the receiver in the laser ranging probe.

[0016] Furthermore, the acquisition and display system calculates the volume of the lesion cavity based on its internal dimensions, including the following steps: S201. Based on the modeling tool, the lesion cyst cavity is fitted into an ellipsoid by the internal size information of the lesion cyst cavity composed of multiple sets of data, and the major axis a, the middle axis b, and the minor axis c of the lesion cyst cavity are obtained. S202. Based on the major axis a, the middle axis b, and the minor axis c of the lesion cyst cavity, calculate the volume V of the lesion cyst cavity according to the formula V=π / 6abc.

[0017] The beneficial effects of this invention are as follows: 1. This invention provides a visualization puncture needle assembly and system for stem cell injection. Under local anesthesia, medication is injected into the lesion cyst cavity, resulting in a smaller surgical wound, less bleeding, and less postoperative discomfort. Simultaneously, a camera probe and a laser ranging probe are designed at the front end of the visualization sleeve, and both are communicatively connected to a data acquisition and display system. On one hand, the camera probe acquires internal images of the lesion cyst cavity, which are then displayed by the data acquisition and display system. This allows for observation of the internal condition of the lesion cyst cavity and also assists in adjusting the position of the laser ranging probe within the cavity. On the other hand, based on multiple sets of data detected by the laser ranging probe, the data acquisition and display system can fit the lesion cyst cavity into an ellipsoid and calculate its volume, thereby determining the dosage of stem cell injection and achieving precise treatment. 2. This invention provides a visualization puncture needle assembly and system for stem cell injection. The second limiter in the limiting injection needle can move along the axial direction of its needle tube, thus precisely limiting the needle insertion length and avoiding excessive or shallow insertion. At the same time, the needle in the limiting injection needle enters after passing through the visualization sleeve. Based on the camera probe, the entire process of needle insertion and injection can be observed, achieving the purpose of real-time monitoring. 3. This invention provides a visualization puncture needle assembly and system for stem cell injection. Before stem cell injection, the inside of the lesion cyst cavity can be pretreated by the irrigator. At the same time, the irrigating tube in the irrigator passes through the visualization sleeve and then inserts the needle. The entire irrigating process can be observed based on the camera probe, achieving the purpose of real-time monitoring. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a visualized puncture needle assembly for stem cell injection according to the present invention; Figure 2 This is a schematic diagram of a visualization puncture needle assembly for stem cell injection according to the present invention (puncture needle sleeve and visualization sleeve). Figure 3 This is a schematic diagram of a visualization puncture needle assembly for stem cell injection according to the present invention (puncture needle sleeve, visualization sleeve and limiting injection needle). Figure 4 This is a schematic diagram of the irrigator in a visual puncture needle assembly for stem cell injection according to the present invention. Figure 5 This is a schematic diagram of a visualization puncture needle assembly for stem cell injection according to the present invention (puncture needle sleeve, visualization sleeve and irrigator). Figure 6 This is a schematic diagram of the usage state of a visual puncture needle assembly for stem cell injection according to the present invention (for stem cell injection in the spinal cord). Figure 7 This is a schematic diagram of the usage state of a visual puncture needle assembly for stem cell injection (for brain stem cell injection) according to the present invention.

[0019] Labeling instructions: 1. Puncture needle sleeve, 2. Puncture needle core, 3. Visualization sleeve, 4. First limiter, 5. Needle tip, 6. Needle tube, 7. Syringe connector, 8. Second limiter, 9. Flushing tube, 10. First branch tube, 11. Second branch tube. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific examples described herein are merely illustrative and not intended to limit the scope of the invention.

[0021] Example 1: Please see Figure 1 , 2 As shown, a visualization puncture needle system for stem cell injection includes a visualization puncture needle assembly and a data acquisition and display system.

[0022] The visualization puncture needle components include: The puncture needle includes a puncture needle core 2 and a puncture needle sleeve 1, which are used to construct a channel from the outside to the lesion cavity (after the puncture is completed, the puncture needle core 2 is pulled out, thus constructing a channel from the outside to the lesion cavity). The visualization sleeve 3 has an outer diameter that matches the inner diameter of the puncture needle sleeve 1. The visualization sleeve 3 is provided with a first limiter 4 connected thereto, and the first limiter 4 can move along the axial direction of the visualization sleeve 3. Several miniature camera probes are located at the front end (end face and side) of the visualization sleeve 3 to collect internal image information of the lesion cavity; Several miniature laser ranging probes are located at the front end (end face and side) of the visualization sleeve 3 to detect the internal size information of the lesion cavity.

[0023] In this embodiment, for example, the first limiter 4 and the visual sleeve 3 are connected by a thread.

[0024] The acquisition and display system is communicatively connected to several camera probes and several laser rangefinder probes. The acquisition and display system is used to acquire and display the internal image information of the lesion cyst cavity. The acquisition and display system is also used to acquire the internal size information of the lesion cyst cavity and calculate the volume of the lesion cyst cavity based on the internal size information of the lesion cyst cavity in order to determine the dosage of stem cell injection.

[0025] Specifically, the acquisition and display system obtains the internal dimensions of the lesion cavity through the following steps: S101. Along the channel from outside to the lesion cyst cavity, based on the internal image of the lesion cyst cavity displayed by the acquisition and display system, the visualization sleeve 3 is placed into the target area inside the lesion cyst cavity. The target area refers to the center position or the position near the center of the lesion cyst cavity. Then, the first limiter 4 is moved to abut against the puncture needle sleeve 1. S102, Rotate the visualization sleeve 3, and in front of the rotating visualization sleeve 3, the acquisition and display system acquires the straight-line distance D from each laser ranging probe to the corresponding point on the inner wall of the lesion cyst cavity, and obtains a set of data in the internal size information of the lesion cyst cavity; S103, Multiple rotations of the visualization sleeve 3, the acquisition and display system acquires multiple sets of data according to S102 to form the internal size information of the lesion cavity.

[0026] In S102, the formula for calculating the straight-line distance D from the laser ranging probe to the corresponding point on the inner wall of the lesion cavity is as follows: D = Bf / x, where B is the baseline distance between the transmitter and receiver in the laser ranging probe, f is the focal length of the optical lens inside the receiver in the laser ranging probe, and x is the offset of the light spot inside the receiver in the laser ranging probe.

[0027] More specifically, the acquisition and display system calculates the volume of the lesion cavity based on its internal dimensions, including the following steps: S201. Based on the modeling tool, the lesion cyst cavity is fitted into an ellipsoid by the internal size information of the lesion cyst cavity composed of multiple sets of data, and the major axis a, the middle axis b, and the minor axis c of the lesion cyst cavity are obtained. S202. Based on the major axis a, middle axis b, and minor axis c of the lesion cavity, calculate the volume V of the lesion cavity according to the formula V=π / 6abc.

[0028] In this embodiment, for example, the acquisition and display system includes a data acquisition unit, a PC (including a display), etc.; the camera probe and the laser rangefinder probe are connected to the acquisition and display system via a wiring harness.

[0029] The following section explains the internal dimensions of the lesion cavity obtained by the acquisition and display system, using data as an example: The acquisition and display system obtains the straight-line distance D from each laser ranging probe to the corresponding point on the inner wall of the lesion cavity, for example: When B is 1mm, f is 800px / mm, and x is 40px, D is calculated to be 20mm. The visualization sleeve 3 is rotated multiple times, and the acquisition and display system obtains multiple sets of data to form the internal size information of the lesion cavity, for example: Rotate 11 times, each time approximately 30°, to obtain 12 sets of data; The acquisition and display system calculates the volume of the lesion cavity based on its internal dimensions, for example: Based on MATLAB software, the values ​​of a were obtained as 80 mm, b as 12 mm, and c as 10 mm. The volume of the lesion cavity is calculated as V = π / 6abc = π / 6·80·12·10 ≈ 5024 mm. 3 ≈5cm 3 .

[0030] According to the above design, the drug is injected into the lesion cavity under local anesthesia, resulting in a smaller surgical wound, less bleeding, and less postoperative discomfort. Simultaneously, an imaging probe captures images of the lesion cavity's interior, which are then displayed through a data acquisition and display system. This allows for observation of the cavity's internal condition and assists in adjusting the laser ranging probe's position within the cavity. Based on multiple sets of data detected by the laser ranging probe, the system can fit the lesion cavity into an ellipsoid and calculate its volume, thereby determining the dosage of stem cell injection and achieving precise treatment.

[0031] Example 2: Please see Figure 1 , 3 As shown, based on Embodiment 1, the visualization puncture needle assembly further includes a limiting injection needle, which comprises a needle 5 (with an opening at the front end) and a needle tube 6. The needle 5 is fixed to and communicates with one end of the needle tube 6, and the outer diameter of the needle 5 is adapted to the inner diameter of the visualization sleeve 3. A syringe connector 7 is provided at the end of the needle tube 6 away from the needle 5, and a second limiter 8 is provided on the needle tube 6 and connected thereto, and the second limiter 8 can move along the axial direction of the needle tube 6. In use, a syringe containing stem cell suspension is connected to the limiting injection needle through the syringe connector 7.

[0032] Preferably, the needle tube 6 is provided with a limit scale to achieve precise adjustment of the second limiter 8.

[0033] In this embodiment, for example, the second limiter 8 and the needle tube 6 are connected by a thread.

[0034] Since stem cell suspension will remain in needle 5 and syringe 6 of the limited injection needle, when preparing stem cell suspension with a syringe, the amount of medication for stem cell injection should be at least the sum of the volume of the lesion cavity and the volume of needle 5 and syringe 6 (known).

[0035] According to the above design, the second limiter 8 in the limiting injection needle can move along the axial direction of its needle tube 6, thus accurately limiting the needle insertion length and avoiding excessive or shallow insertion. At the same time, the needle 5 in the limiting injection needle enters after passing through the visualization sleeve 3. Based on the camera probe, the entire process of needle insertion and injection can be observed, achieving the purpose of real-time monitoring.

[0036] Furthermore, it should be noted that this visualization puncture needle assembly can be used for stem cell injection into the spinal cord, such as... Figure 6 As shown, it can also be used for brain stem cell injections, such as... Figure 7 As shown.

[0037] Example 3: Please see Figure 1 , 4 As shown in Figure 5, based on Embodiment 1, the visualization puncture needle assembly further includes an irrigator. The irrigator includes an irrigation tube 9, a first branch tube 10, and a second branch tube 11. The irrigation tube 9 is a dual-channel tube, and its outer diameter is adapted to the inner diameter of the visualization sleeve 3. The irrigation tube 9 is made of a soft material. The first branch tube 10 and the second branch tube 11 are respectively connected to the dual channels of the irrigation tube 9. In use, a syringe containing irrigating fluid is connected to the first branch tube 10, and the irrigated fluid is discharged through the second branch tube 11.

[0038] According to the above design, before stem cell injection, the inside of the lesion cyst cavity can be pretreated by the irrigator. At the same time, the irrigating tube 9 in the irrigator passes through the visualization sleeve 3 and then inserts the needle. The entire irrigating process can be observed based on the camera probe, achieving the purpose of real-time monitoring.

[0039] This invention is not limited to the specific embodiments described above. Those skilled in the art can implement this invention using various other specific embodiments based on the content disclosed herein. Therefore, any design that adopts the design structure and concept of this invention and makes some simple changes or modifications falls within the scope of protection of this invention.

Claims

1. A visualization puncture needle assembly for stem cell injection, characterized in that: include: A puncture needle, comprising a puncture needle core and a puncture needle sleeve, is used to construct a channel from outside the body to the lesion cavity; A visualization sleeve, the outer diameter of which is adapted to the inner diameter of the puncture needle sleeve, and a first limiter connected thereto on the visualization sleeve, and the first limiter can move along the axial direction of the visualization sleeve. Several camera probes are located at the front end of the visualization sleeve to collect internal image information of the lesion cavity; Several laser ranging probes are located at the front end of the visualization sleeve to detect the internal dimensions of the lesion cavity.

2. The visualization puncture needle assembly for stem cell injection according to claim 1, characterized in that: Also includes: A limiting injection needle includes a needle and a needle tube. The needle is fixed to one end of the needle tube and communicates with it. The outer diameter of the needle is adapted to the inner diameter of the visualization sleeve. A syringe connector is provided at one end of the needle tube away from the needle. A second limiter is provided on the needle tube and is connected to it. The second limiter can move along the axial direction of the needle tube.

3. The visualization puncture needle assembly for stem cell injection according to claim 1, characterized in that: Also includes: A flushing device, comprising a flushing pipe and a first branch pipe and a second branch pipe, wherein the flushing pipe is a dual-channel pipe, the outer diameter of the flushing pipe is adapted to the inner diameter of the visualization sleeve, and the flushing pipe is made of a soft material, and the first branch pipe and the second branch pipe are respectively connected to the dual channels of the flushing pipe.

4. A visualization puncture needle assembly for stem cell injection according to any one of claims 1 to 3, characterized in that: The first limiter and the visual sleeve are connected by a thread.

5. A visualization puncture needle assembly for stem cell injection according to claim 2, characterized in that: The second limiter is threadedly connected to the needle tube.

6. A visualization puncture needle assembly for stem cell injection according to claim 2 or 5, characterized in that: The syringe is equipped with a limit scale.

7. A visualization puncture needle system for stem cell injection, characterized in that: include: The visualization puncture needle assembly according to any one of claims 1 to 6; The acquisition and display system is communicatively connected to several camera probes and several laser ranging probes. The acquisition and display system is used to acquire and display the internal image information of the lesion cyst cavity. The acquisition and display system is also used to acquire the internal size information of the lesion cyst cavity and calculate the volume of the lesion cyst cavity based on the internal size information of the lesion cyst cavity to determine the dosage of stem cell injection.

8. A visualization puncture needle system for stem cell injection according to claim 7, characterized in that: The acquisition and display system obtains the internal size information of the lesion cavity, including the following steps: S101. Along the channel from outside the body to the lesion cyst cavity, based on the internal image of the lesion cyst cavity displayed by the acquisition and display system, the visualization sleeve is placed into the target area within the lesion cyst cavity, and then the first limiter is moved to abut against the puncture needle sleeve. S102. Rotate the visualization sleeve. Before rotating the visualization sleeve, the acquisition and display system acquires the straight-line distance D from each laser ranging probe to the corresponding point on the inner wall of the lesion cyst cavity, and obtains a set of data in the internal size information of the lesion cyst cavity. S103. The visualization sleeve is rotated multiple times, and the acquisition and display system acquires multiple sets of data to form the internal size information of the lesion cavity according to S102.

9. A visualization puncture needle system for stem cell injection according to claim 8, characterized in that: In step S102, the formula for calculating the straight-line distance D from the laser ranging probe to the corresponding point on the inner wall of the lesion cavity is as follows: D = Bf / x, where B is the baseline distance between the transmitter and receiver in the laser ranging probe, f is the focal length of the optical lens inside the receiver in the laser ranging probe, and x is the offset of the light spot inside the receiver in the laser ranging probe.

10. A visualization puncture needle system for stem cell injection according to claim 7, characterized in that: The acquisition and display system calculates the volume of the lesion cavity based on its internal dimensions, including the following steps: S201. Based on the modeling tool, the lesion cyst cavity is fitted into an ellipsoid by the internal size information of the lesion cyst cavity composed of multiple sets of data, and the major axis a, the middle axis b, and the minor axis c of the lesion cyst cavity are obtained. S202. Based on the major axis a, the middle axis b, and the minor axis c of the lesion cyst cavity, calculate the volume V of the lesion cyst cavity according to the formula V=π / 6abc.

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