Composition with relieving effect for intervening eczema action mechanism

Abstract

The invention discloses a soothing composition with an eczema action mechanism intervention function. Comprising the following components in parts by weight: 0.05 to 0.3 part of calamine, 0.05 to 0.2 part of zinc oxide, 0.001 to 2 parts of lactobacillus / soybean milk fermentation product filtrate, 0.001 to 3 parts of oat beta-glucan, 0.001 to 2 parts of a plant compound, 0.001 to 5 parts of a herba portulacae extract, 0.001 to 0.5 part of a chrysanthellum indicum extract and 0.001 to 0.5 part of a herba centellae extract. The calamine and the zinc oxide are adopted and compounded with multiple natural functional components, and then the composition with the relieving effect remarkably improved is prepared. The hyaluronidase activity inhibition rate of the moisturizer prepared from the composition reaches 55% or above. The moisturizing cream prepared from the composition also has a remarkable eczema removal effect, the effective rate of eczema removal reaches 100%, and the cure rate reaches 30%.

Description

Technical Field

[0001] This invention relates to the field of skincare technology, specifically to a soothing composition that has an intervention mechanism for eczema. Background Technology

[0002] Eczema is a skin inflammation characterized by intense itching, caused by a variety of internal and external factors. Its pathogenesis is complex, often resulting from the interaction of internal and external factors, leading to a delayed-type hypersensitivity reaction. Internal factors include chronic digestive system diseases, endocrine disorders, excessive fatigue, mental stress, insomnia, emotional changes, and infections, while external factors include living environment, climate change, and food. Typical symptoms of eczema usually include erythema, edema, itching, and rash.

[0003] Patent document CN109481386A describes a multi-effect infant care cream and its preparation method. This cream uses zinc oxide, calamine, Melaleuca alternifolia leaf oil, olive fruit unsaponifiables, bisabolol, and hydroxyphenylpropionamide benzoic acid to form a multi-effect skin care composition. This cream soothes and relieves allergies, itching, inflammation, and irritation in infants, while also protecting the skin and repairing and preventing diaper rash. However, this cream has a very high content of calamine and zinc oxide, while the content of plant extracts is low, making it unsuitable for long-term use. Summary of the Invention

[0004] In view of the shortcomings of the prior art, the purpose of this invention is to provide a soothing composition with an intervention mechanism for eczema.

[0005] The objective of this invention is achieved through the following technical solution: In a first aspect, the present invention provides a soothing composition with an intervention mechanism for eczema, comprising the following components in parts by weight: calamine 0.05-0.3 parts, zinc oxide 0.05-0.2 parts, lactobacillus / soy milk fermentation product filtrate 0.001-2 parts, oat β-glucan 0.001-3 parts, plant compound 0.001-2 parts, purslane extract 0.001-5 parts, golden chamomile extract 0.001-0.5 parts, and centella asiatica extract 0.001-0.5 parts; The plant compound is a combination of Sophora flavescens root extract, Ophiopogon japonicus root extract and Prickly pear cactus stem extract.

[0006] Preliminary experiments of this invention have shown that if the content range of each component is too high or too low, the soothing effect will decrease to varying degrees.

[0007] As a preferred embodiment, the mass ratio of Sophora flavescens root extract, Ophiopogon japonicus root extract and Prickly pear cactus stem extract in the plant compound is 1:1:1.

[0008] Secondly, the present invention provides the application of a soothing composition with an intervention mechanism for eczema in the preparation of skin care products.

[0009] Thirdly, the present invention provides a moisturizing cream with soothing effects, comprising the aforementioned soothing composition with the mechanism of action of intervening in eczema, and further comprising at least one of emollient, moisturizer, thickener, emulsifier, antioxidant, preservative, and solvent.

[0010] As a preferred embodiment, the following components are included in parts by weight: 0.05-0.3 parts calamine, 0.05-0.2 parts zinc oxide, 0.001-2 parts lactobacillus / soybean fermentation product filtrate, 0.001-3 parts oat β-glucan, 0.001-2 parts plant compound, 0.001-5 parts purslane extract, 0.001-0.5 parts golden chamomile extract, 0.001-0.5 parts centella asiatica extract, 5-25 parts emollient, 8-16 parts moisturizer, 0.1-2 parts thickener, 0.5-2 parts emulsifier, 0.01-0.1 parts antioxidant, 0.1-0.5 parts preservative, and solvent to a total of 100 parts.

[0011] As a preferred embodiment, the emollient is selected from at least one of sunflower seed oil, olive fruit oil, camellia seed oil, shea butter, macadamia seed oil, isohexadecane, and polydimethylsiloxane / polydimethylsiloxane alcohol.

[0012] As a preferred embodiment, the moisturizer is selected from at least one of glycerin and butylene glycol.

[0013] As a preferred embodiment, the thickener is selected from sodium chloride.

[0014] As a preferred embodiment, the emulsifier is selected from cetyl PEG / PPG-10 / 1 polydimethylsiloxane.

[0015] As a preferred embodiment, the antioxidant is selected from at least one of pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester, butanediol / glyceryl caprylate / p-hydroxyacetophenone / capryloyl hydroxamic acid.

[0016] As a preferred embodiment, the preservative is selected from phenoxyethanol / ethylhexylglycerin.

[0017] As a preferred embodiment, the solvent is water.

[0018] Fourthly, the present invention provides a method for preparing a moisturizing cream with soothing effects, comprising the following steps: The soothing composition with the mechanism of action to intervene in eczema, emollient, moisturizer, thickener, emulsifier, antioxidant, and preservative are weighed according to the weight proportions and added to the solvent. After stirring evenly, the soothing composition with the mechanism of action to intervene in eczema is obtained.

[0019] Compared with the prior art, the present invention has the following beneficial effects: This invention utilizes calamine and zinc oxide, combined with various natural active ingredients (Lactobacillus / soybean fermentation product filtrate, oat β-glucan, plant compounds, purslane extract, golden chamomile extract, and centella asiatica extract) to prepare a composition with significantly enhanced soothing effects. The moisturizing cream prepared from this composition exhibits a hyaluronidase activity inhibition rate of over 55%.

[0020] The moisturizing cream prepared from the composition of the present invention also has a significant effect on relieving eczema. After testing, the effectiveness rate of relieving eczema reached 100% and the cure rate reached 30% after 14 days of use. Detailed Implementation

[0021] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0022] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0023] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0024] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0025] In the following embodiments of the present invention, a soothing composition with an intervention mechanism for eczema is provided, comprising the following components in parts by weight: calamine 0.05-0.3 parts, zinc oxide 0.05-0.2 parts, lactobacillus / soy milk fermentation product filtrate 0.001-2 parts, oat β-glucan 0.001-3 parts, plant compound 0.001-2 parts, purslane extract 0.001-5 parts, golden chamomile extract 0.001-0.5 parts, and centella asiatica extract 0.001-0.5 parts; The plant compound is a combination of Sophora flavescens root extract, Ophiopogon japonicus root extract and Prickly pear cactus stem extract.

[0026] In one specific embodiment, the Lactobacillus / soy milk fermentation product filtrate is a commercial raw material, Aotingmin, from Jucheng Company. The weight parts of the Lactobacillus / soy milk fermentation product filtrate added are the same as the weight parts of the commercial raw material added. The commercial raw material comprises water, Lactobacillus / soy milk fermentation product filtrate, butylene glycol, and 1,2-pentanediol; its active ingredient is the Lactobacillus / soy milk fermentation product filtrate.

[0027] In one specific embodiment, the oat β-glucan is a commercially available oat β-glucan ingredient from Tylenol. The weight parts of oat β-glucan added are the same as the weight parts of this commercially available ingredient. This commercially available ingredient contains water, butylene glycol, oat (AVENA SATIVA) β-glucan, and 1,2-hexanediol; its active ingredient is oat (AVENA SATIVA) β-glucan.

[0028] In a specific embodiment, the plant complex is a composition of Sophora flavescens root extract, Ophiopogon japonicus root extract, and Opuntia ficus-indica stem extract, and the specific commercial raw material name is IrriSmoth s II FN. The added weight parts of the plant complex are the added weight parts of this commercial raw material. This commercial raw material contains water, glycerol, trehalose, Sophora flavescens root extract, Ophiopogon japonicus root extract, Opuntia ficus - indica stem extract, 1,2 - pentanediol, 1,2 - hexanediol; its active components are Sophora flavescens root extract, Ophiopogon japonicus root extract, and Opuntia ficus - indica stem extract, and the mass ratio of the three is 1:1:1.

[0029] In a specific embodiment, the Portulaca oleracea extract is the commercial raw material Portulaca oleracea extract solution from Heji Company. The added weight parts of the Portulaca oleracea extract are the added weight parts of this commercial raw material. This commercial raw material contains water, Portulaca oleracea extract, and butanediol; its active component is Portulaca oleracea extract.

[0030] In a specific embodiment, the Matricaria recutita extract is the commercial raw material Matricaria recutita hydrosol. The added weight parts of the Matricaria recutita extract are the added weight parts of this commercial raw material. This commercial raw material contains Matricaria recutita flower extract water / butanediol / 1,2 - hexanediol / caprylohydroxamic acid; its active component is Matricaria recutita flower extract water.

[0031] In a specific embodiment, the Centella asiatica extract is the commercial raw material SkbrellaTM CT Centella asiatica extract from Baocui Company. The added weight parts of the Centella asiatica extract are the added weight parts of this commercial raw material. This commercial raw material contains water, Centella asiatica flower / leaf / stem extract, glycerol, 1,2 - hexanediol, 1,2 - pentanediol, and p - hydroxyacetophenone; its active component is Centella asiatica flower / leaf / stem extract.

[0032] In the following embodiments, a soothing moisturizing cream is also specifically provided, comprising the following components in parts by weight: calamine 0.05-0.3 parts, zinc oxide 0.05-0.2 parts, lactobacillus / soybean fermentation product filtrate 0.001-2 parts, oat β-glucan 0.001-3 parts, plant compound 0.001-2 parts, purslane extract 0.001-5 parts, golden chamomile extract 0.001-0.5 parts, centella asiatica extract 0.001-0.5 parts, emollient 5-25 parts, moisturizer 8-16 parts, thickener 0.1-2 parts, emulsifier 0.5-2 parts, antioxidant 0.01-0.1 parts, preservative 0.1-0.5 parts, and solvent to make up to 100 parts.

[0033] In one specific embodiment, the emollient is specifically sunflower seed oil, olive fruit oil, camellia seed oil, shea butter, macadamia seed oil, isohexadecane, polydimethylsiloxane, and polydimethylsiloxane / polydimethylsiloxane alcohol (purchased from Wanlu Company, commercial raw material name is PMX-1403); preferably, the weight ratio of sunflower seed oil, olive fruit oil, camellia seed oil, shea butter, macadamia seed oil, isohexadecane, and polydimethylsiloxane / polydimethylsiloxane alcohol is 5.0-15.0:0.001-3:0.001-3:0.001-3:0.001-3:1.0-3.0:0.1-0.5.

[0034] In one specific embodiment, the moisturizer is glycerin and butylene glycol; preferably, the weight ratio of glycerin to butylene glycol is 8.0-15.0:0.01-1.

[0035] In one specific embodiment, the thickener is sodium chloride-free.

[0036] In one specific embodiment, the emulsifier is cetyl PEG / PPG-10 / 1 polydimethylsiloxane (purchased from Sacco, commercial name BESTCARE SE-900).

[0037] In one specific embodiment, the antioxidant is specifically pentaerythritol tetra(bis-tert-butylhydroxycinnamic acid) ester, butylene glycol / glyceryl caprylate / p-hydroxyacetophenone / capryloyl hydroxamic acid (purchased from Xinran Company, commercial raw material name XR-P01). Preferably, the weight ratio of pentaerythritol tetra(bis-tert-butylhydroxycinnamic acid) ester, butylene glycol / glyceryl caprylate / p-hydroxyacetophenone / capryloyl hydroxamic acid is 0.01-0.1:0.01-0.1.

[0038] In one specific embodiment, the preservative is phenoxyethanol / ethylhexylglycerin (purchased from Minghong Company, the commercial raw material name is Activonol PAF E91).

[0039] In one specific embodiment, the solvent is water.

[0040] In the following examples, all raw materials used are commercially available, and the preparation methods are conventional. This invention does not impose any special limitations.

[0041] Example 1 This embodiment provides a soothing moisturizing cream, including a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight ratio of its raw materials are shown in Table 1 (wherein, the weight ratio of water is to be made up to 100 parts). The preparation steps of the moisturizing cream are as follows: S1: Mix sunflower seed oil, isohexadecane, cetyl PEG / PPG-10 / 1 polydimethylsiloxane, polydimethylsiloxane / polydimethylsiloxane alcohol, pentaerythritol tetra(bis-tert-butylhydroxyhydrogenated cinnamic acid) ester, olive fruit oil, camellia seed oil, shea butter, and macadamia seed oil evenly. S2: Add calamine and zinc oxide to the mixture from step S1, disperse evenly, and obtain phase A; S3: Mix water, glycerol, sodium chloride, phenoxyethanol / ethylhexylglycerol, and butylene glycol 12 and stir until homogeneous. Stir slowly to obtain phase B. S4: Slowly add phase A prepared in step S2 to phase B prepared in step S3 and stir until homogeneous; S5: Add lactobacillus / soy milk fermentation product filtrate, oat β-glucan, plant compound (sophora flavescens root extract, ophiopogon japonicus root extract and prickly pear cactus stem extract in a mass ratio of 1:1:1), purslane extract, golden chamomile extract and centella asiatica extract to the mixture in step S4, homogenize and stir evenly to obtain the moisturizing cream.

[0042] Example 2 This embodiment provides a soothing moisturizing cream, including a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight ratio of each raw material are shown in Table 1 (wherein, the weight ratio of water is to be made up to 100 parts). The preparation steps of the moisturizing cream are the same as in Example 1.

[0043] Example 3 This embodiment provides a soothing moisturizing cream, including a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight ratio of each raw material are shown in Table 1 (wherein, the weight ratio of water is to be made up to 100 parts). The preparation steps of the moisturizing cream are the same as in Example 1.

[0044] Example 4 This embodiment provides a soothing moisturizing cream, including a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight ratio of each raw material are shown in Table 1 (wherein, the weight ratio of water is to be made up to 100 parts). The preparation steps of the moisturizing cream are the same as in Example 1.

[0045] Table 1 Comparative Example 1 This comparative example provides a soothing moisturizing cream, comprising a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight ratio of its ingredients are shown in Table 2 (wherein, the weight ratio of water is to make up to 100 parts). Compared with Example 1, the only difference is that: no plant compound (sophora flavescens root extract, ophiopogon japonicus root extract and prickly pear cactus stem extract in a mass ratio of 1:1:1) is added, and the weight ratio of purslane extract is 3 parts. The preparation steps of the moisturizing cream are the same as those of Example 1.

[0046] Comparative Example 2 This comparative example provides a soothing moisturizing cream, comprising a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight proportions of its ingredients are shown in Table 2 (wherein, the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that: no lactobacillus / soy milk fermentation product filtrate is added, and the weight proportion of the plant compound is 2.5 parts. The preparation steps of the moisturizing cream are the same as in Example 1.

[0047] Comparative Example 3 This comparative example provides a soothing moisturizing cream, comprising a soothing composition with an intervention mechanism for eczema, the composition and weight proportions of its ingredients are shown in Table 2 (wherein the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that: purslane extract is not added, and the weight proportion of golden chamomile extract is 1.5 parts. The preparation steps of the moisturizing cream are the same as in Example 1.

[0048] Comparative Example 4 This comparative example provides a soothing moisturizing cream, comprising a soothing composition with an intervention mechanism for eczema, the composition and weight proportions of its ingredients are shown in Table 2 (wherein the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that oat β-glucan is not added, and the weight proportions of Lactobacillus / soy milk fermentation product filtrate are 1.5 parts. The preparation steps of the moisturizing cream are the same as in Example 1.

[0049] Comparative Example 5 This comparative example provides a soothing moisturizing cream, comprising a soothing composition with an intervention mechanism for eczema, the composition and weight proportions of its ingredients are shown in Table 2 (wherein the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that: golden chamomile extract is not added, and the weight proportion of purslane extract is 1.5 parts. The preparation steps of the moisturizing cream are the same as in Example 1.

[0050] Comparative Example 6 This comparative example provides a soothing moisturizing cream, comprising a soothing composition that intervenes in the mechanism of action of eczema. The composition and weight proportions of its ingredients are shown in Table 2 (wherein, the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that Centella asiatica extract is not added, and the weight proportion of Portulaca oleracea extract is 1.5 parts. The preparation steps of the moisturizing cream are the same as in Example 1.

[0051] Comparative Example 7 This comparative example provides a soothing moisturizing cream, comprising a soothing composition with an intervention mechanism for eczema. The composition and weight proportions of its ingredients are shown in Table 2 (wherein the weight proportions of water are to be made up to 100 parts). The only difference from Example 1 is that an equal weight proportion of aloe vera extract (purchased from Bensondo Co., Ltd., trade name: Aloe Vera Extract) is used instead of golden chamomile extract. The preparation steps of the moisturizing cream are the same as in Example 1.

[0052] Table 2 Efficacy verification: 1) The moisturizing creams prepared in Examples 1-4 and Comparative Examples 1-7 were used as test products to test their soothing effects.

[0053] High molecular weight hyaluronic acid can inhibit inflammatory responses, thus alleviating discomfort caused by skin inflammation. High molecular weight hyaluronic acid is degraded by hyaluronidase, resulting in a decrease in its content. This decomposition produces the degradation product N-acetylglucosamine. Measuring the N-acetylglucosamine content in the reaction system can indirectly reflect the activity of hyaluronidase. Through experimental design, the inhibition rate of hyaluronidase by measuring the N-acetylglucosamine content in the reaction system is determined. If the inhibition rate of the experimental sample is better than (higher than) that of the blank control group, and the statistical difference P value is <0.05, then the experimental sample can be considered to have a certain soothing effect.

[0054] The specific method for determining the in vitro hyaluronidase inhibition rate is a conventional method. An appropriate amount of the test product (concentration 5%) is reacted with a solution containing hyaluronidase to induce a colorimetric reaction. The absorbance is measured at 530 nm, and the hyaluronidase activity inhibition rate (%) is calculated using the following formula: Hyaluronidase inhibition rate (%) = [(CD) - (AB)] / (CD) × 100%; In the formula, A is the OD value of the test sample solution using (hyaluronidase + test sample + potassium hyaluronate); B is the OD value of the test sample blank solution using (hyaluronidase + test sample + acetate buffer); C is the OD value of the control sample solution using (hyaluronidase + deionized water + potassium hyaluronate); and D is the OD value of the control sample blank solution using (acetate buffer + deionized water + acetate buffer).

[0055] The results of the hyaluronidase activity inhibition rate measured for each test sample group are shown in Table 3 (the data in Table 3 are the average values ​​of the three parallel samples).

[0056] Table 3 As shown in Table 3, the moisturizing creams prepared in Examples 1-4 have excellent soothing effects, with hyaluronidase activity inhibition rates exceeding 45%. Example 2, in particular, exhibits the best soothing effect, with a hyaluronidase activity inhibition rate exceeding 55%.

[0057] As can be seen from the comparison between Example 1 and Comparative Examples 1-7, when any one of the following ingredients—Lactobacillus / soybean ferment filtrate, oat β-glucan, plant compound, purslane extract, golden chamomile extract, and centella asiatica extract—was missing from the soothing composition used in the moisturizing cream, the hyaluronidase activity inhibition rate of the moisturizing creams prepared in Comparative Examples 1-7 was significantly lower than that of Example 1 (a decrease of 4.45-15.36%). This indicates that the components in the soothing composition can synergistically enhance the soothing effect.

[0058] 2) The moisturizing creams prepared in Example 1 and Comparative Examples 1, 3, 5, 6, and 7 were used as test products for eczema treatment efficacy testing.

[0059] Fifty subjects of any age and gender diagnosed with eczema were selected and enrolled. They were divided into six groups of ten subjects each. Subjects applied the test product three times daily for two weeks, after which the efficacy was observed. The efficacy criteria were: 1) Cured: complete disappearance of eczema symptoms; 2) Improved: significant reduction in eczema lesions; 3) Ineffective: only slight reduction or no effect on eczema symptoms. The sum of cured and improved symptoms was the effective rate. The eczema-reducing effects of each test product are shown in Table 4.

[0060] Table 4 As shown in Table 4, the moisturizing cream prepared in Example 1 has excellent eczema-relieving efficacy, with an effectiveness rate of 100% and a cure rate of 30%. In contrast, the moisturizing creams prepared in Comparative Examples 1, 3, 5, and 7 all showed inferior eczema-relieving efficacy compared to Example 1, with effectiveness rates of 80-90% and cure rates of 0-20%. Therefore, the soothing composition composed of the specific components of this invention (calamine, zinc oxide, lactobacillus / soybean fermentation product filtrate, oat β-glucan, plant compound, purslane extract, golden chamomile extract, and centella asiatica extract) exhibits synergistic effects, significantly improving the eczema-relieving efficacy.

[0061] In addition, the present invention further conducted human safety tests on the moisturizing creams prepared in Examples 1-4, and no adverse reactions were found in any of the tests.

[0062] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A composition with soothing effects that intervenes in the mechanism of action of eczema, characterized in that, The product comprises the following components in parts by weight: calamine 0.05-0.3 parts, zinc oxide 0.05-0.2 parts, lactobacillus / soybean fermentation product filtrate 0.001-2 parts, oat β-glucan 0.001-3 parts, plant compound 0.001-2 parts, purslane extract 0.001-5 parts, golden chamomile extract 0.001-0.5 parts, and centella asiatica extract 0.001-0.5 parts. The plant compound is a combination of Sophora flavescens root extract, Ophiopogon japonicus root extract and Prickly pear cactus stem extract.

2. The soothing composition with an intervention mechanism for eczema according to claim 1, characterized in that, In the plant compound, the mass ratio of Sophora flavescens root extract, Ophiopogon japonicus root extract and Prickly pear cactus stem extract is 1:1:

1.

3. The use of a soothing composition with an intervention mechanism for eczema according to any one of claims 1-2 in the preparation of skin care products.

4. A moisturizing cream with soothing effects, characterized in that, The soothing composition having an intervention mechanism for eczema as described in any one of claims 1-2 further includes at least one of emollients, moisturizers, thickeners, emulsifiers, antioxidants, preservatives, and solvents.

5. The moisturizing cream with soothing effects according to claim 4, characterized in that, The product comprises the following components in parts by weight: calamine 0.05-0.3 parts, zinc oxide 0.05-0.2 parts, lactobacillus / soybean fermentation product filtrate 0.001-2 parts, oat β-glucan 0.001-3 parts, plant compound 0.001-2 parts, purslane extract 0.001-5 parts, golden chamomile extract 0.001-0.5 parts, centella asiatica extract 0.001-0.5 parts, emollient 5-25 parts, moisturizer 8-16 parts, thickener 0.1-2 parts, emulsifier 0.5-2 parts, antioxidant 0.01-0.1 parts, preservative 0.1-0.5 parts, and solvent to a total of 100 parts.

6. The moisturizing cream with soothing effects according to claim 4 or 5, characterized in that, The emollient is selected from at least one of sunflower seed oil, olive fruit oil, camellia seed oil, avocado fruit oil, macadamia seed oil, isohexadecane, and polydimethylsiloxane / polydimethylsiloxane alcohol.

7. The moisturizing cream with soothing effects according to claim 4 or 5, characterized in that, The moisturizer is selected from at least one of glycerin and butylene glycol.

8. The moisturizing cream with soothing effects according to claim 4 or 5, characterized in that, The thickener is selected from sodium chloride; The emulsifier is selected from cetyl PEG / PPG-10 / 1 polydimethylsiloxane.

9. The moisturizing cream with soothing effects according to claim 4 or 5, characterized in that, The antioxidant is selected from at least one of pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester, butanediol / glyceryl caprylate / p-hydroxyacetophenone / caprylyl hydroxamic acid; The preservative is selected from phenoxyethanol / ethylhexylglycerin; The solvent is water.

10. A method for preparing a moisturizing cream with soothing effects according to any one of claims 4-9, characterized in that, Includes the following steps: The soothing composition with the mechanism of action to intervene in eczema, emollient, moisturizer, thickener, emulsifier, antioxidant, and preservative are weighed according to the weight proportions and added to the solvent. After stirring evenly, the soothing composition with the mechanism of action to intervene in eczema is obtained.

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