Tightening and relieving composition containing oxyresveratrol and application

Abstract

The invention relates to a tightening and relieving composition containing oxyresveratrol and application, and belongs to the technical field of cosmetics. The invention firstly provides a firming and relieving composition containing oxyresveratrol. The firming and relieving composition containing oxyresveratrol is prepared from oxyresveratrol particles, leontopodium alpinum extract, achillea millefolium extract and artemisia capillaris extract according to the mass ratio of (0.05-2): (1-5): (0.01-2): (0.01-2). Wherein the oxidized resveratrol particles are obtained by loading oxidized resveratrol with lignin as a carrier, and the light stability of oxidized resveratrol is greatly improved. In addition, through the synergistic effect of the four components, the composition can meet the firming and anti-aging effects in multiple aspects of promoting generation, inhibiting decomposition, accelerating cell renewal and the like of the collagen and the elastin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and more particularly to a firming and soothing composition containing oxidized resveratrol and its application. Background Technology

[0002] Oxidized resveratrol is a natural active ingredient extracted from plants or obtained through the oxidation of resveratrol. As a derivative of resveratrol, it possesses stronger biological activity, thus showing great application potential in cosmetics and functional foods. However, the phenolic hydroxyl groups and conjugated systems in the molecular structure of oxidized resveratrol make it extremely sensitive to environmental factors such as light, heat, and oxygen. Under light, it readily undergoes isomerization, degradation, and oxidation reactions, leading to a significant reduction in its activity and a darkening of its color (such as yellowing or browning). This not only affects the product's appearance but also severely limits its formulation applications and shelf life.

[0003] Existing technologies often employ cyclodextrin or liposomes for encapsulation to improve photostability, but these methods suffer from drawbacks such as low encapsulation efficiency and concerns about the safety of using synthetic polymers. Lignin, a widely available, inexpensive, and biodegradable natural polymer, possesses a three-dimensional network structure rich in phenolic hydroxyl groups and ether bonds, exhibiting excellent UV absorption and antioxidant properties, making it an ideal bio-based carrier material. Currently, there are no reports of using lignin to load oxidized resveratrol to improve its photostability. Furthermore, providing a composition containing photostability-stabilized oxidized resveratrol for application in cosmetics also holds significant value. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a firming and soothing composition containing oxidized resveratrol and its application.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] In a first aspect, the present invention provides a firming and soothing composition containing oxidized resveratrol, comprising oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-2):(1-5):(0.01-2):(0.01-2); wherein the oxidized resveratrol particles are obtained by loading oxidized resveratrol onto lignin as a carrier.

[0007] Oxidized resveratrol can reduce the content of AGEs induced by glycosylation and increase collagen expression; it can also reduce p16INK4a expression and maintain cell proliferation capacity; in addition, oxidized resveratrol can improve skin function, increase epidermal thickness, and promote keratinocyte differentiation.

[0008] Leonurus acid A in edelweiss extract can inhibit the expression of matrix metalloproteinase MMP-1 and reduce the degradation of collagen and elastin.

[0009] Yarrow extract can inhibit elastase and promote the proliferation of epidermal keratinocytes, thus restoring the elasticity and balance of skin fibrous tissue and accelerating skin cell metabolism.

[0010] Artemisia capillaris extract can inhibit hyaluronidase to protect hyaluronic acid from being broken down, increase skin moisture content, and reduce wrinkles and skin sagging.

[0011] This invention utilizes lignin-loaded oxidized resveratrol to obtain oxidized resveratrol particles, which greatly improves the photostability of oxidized resveratrol. Furthermore, the oxidized resveratrol particles are rationally combined with extracts of Edelweiss, Yarrow, and Artemisia capillaris. These four components can synergistically promote the production of collagen and elastin, improve the skin elasticity, skin firmness, transepidermal water loss rate, and facial redness of the subjects, and can satisfy the effects of firming and anti-aging from multiple dimensions.

[0012] Furthermore, the firming and soothing composition containing oxidized resveratrol comprises oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-1):(1-3.5):(0.01-1):(0.01-1).

[0013] Preferably, the firming and soothing composition containing oxidized resveratrol comprises oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.1-1):(2-3.5):(0.2-1):(0.2-1).

[0014] Preferably, the firming and soothing composition containing oxidized resveratrol comprises oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of 0.1:2:0.2:0.2.

[0015] Furthermore, the preparation method of the oxidized resveratrol particles includes the following steps:

[0016] S1. Take resveratrol oxide and lignin in a mass ratio of 1:2-5, use ethanol as solvent, prepare a solution with a concentration of 0.5-1 mg / mL, stir for 1-2 h, remove insoluble matter, and obtain the solution system;

[0017] S2. While stirring, add deionized water dropwise, equivalent to 7-9 times the weight of the solution system, and continue stirring for 5-10 minutes to obtain oxidized resveratrol granules.

[0018] Preferably, the mass ratio of oxidized resveratrol to lignin in step S1 is 1:3.5-5, and more preferably 1:3.5.

[0019] Preferably, in step S1, the concentration of the prepared solution is 1 mg / mL, and the mixture is stirred for 1 hour.

[0020] Preferably, step S2 involves adding deionized water, equivalent to 8 times the weight of the solution system, dropwise while stirring, and continuing to stir for 8 minutes to obtain oxidized resveratrol granules.

[0021] Secondly, the present invention provides the use of any of the above-described firming and soothing compositions containing oxidized resveratrol in the preparation of firming and anti-aging cosmetics.

[0022] Furthermore, the firming and soothing composition containing oxidized resveratrol accounts for 1-5% of the total mass of the cosmetic.

[0023] Preferably, the firming and soothing composition containing oxidized resveratrol accounts for 3% of the total mass of the cosmetic.

[0024] Furthermore, the cosmetic product is a toner, lotion, cream, mask, serum, or spray.

[0025] Preferably, the cosmetic is a lotion.

[0026] Thirdly, the present invention provides an emulsion comprising the following ingredients by weight percentage: 1-5% of any of the above-described firming and soothing compositions containing oxidized resveratrol, 3-4% of a moisturizer, 0.1-0.5% of a thickener, 0.5-2.5% of an emulsifier, 4.5-6.5% of an oil, 0.5-3% of a preservative, 0.1-0.5% of a pH adjuster, and the balance being water.

[0027] Further, the emulsion comprises the following ingredients by weight percentage: 1-5% of any of the above-described firming and soothing compositions containing oxidized resveratrol, 3.5% of moisturizer, 0.2% of thickener, 2.5% of emulsifier, 6.5% of oil, 3% of preservative, 0.2% of pH adjuster, and the balance being water.

[0028] Furthermore, the moisturizer includes, but is not limited to, any one or more of glycerin, butylene glycol, pentylene glycol, sorbitol, and methyl glucetol polyether-10 / 20.

[0029] Furthermore, the thickeners include, but are not limited to, one or more of carbomer 980, xanthan gum, and hydroxyethyl cellulose.

[0030] Furthermore, the emulsifier includes, but is not limited to, any one or more of C14-22 alkyl alcohols / C12-20 alkyl glucosides and cetearyl alcohol.

[0031] Furthermore, the oil includes, but is not limited to, any one or more of caprylic / capric triglyceride, polydimethylsiloxane, and squalane.

[0032] Furthermore, the preservatives include, but are not limited to, one or more of 1,2-hexanediol, p-hydroxyacetophenone, 1,3-propanediol, and sorbic acid.

[0033] Furthermore, the pH adjuster includes, but is not limited to, any one or more of arginine, sodium hydroxide, and succinic acid.

[0034] Preferably, the humectant is glycerin, the thickener is carbomer 980, the emulsifier is C14-22 alkyl alcohol / C12-20 alkyl glucoside and cetearyl alcohol, the oil is caprylic / capric triglyceride and polydimethylsiloxane, the preservative is 1,2-hexanediol, p-hydroxyacetophenone and 1,3-propanediol, and the pH adjuster is arginine.

[0035] Furthermore, the preparation process of the emulsion includes the following steps:

[0036] 1) Mix each component of phase A with water and stir. Heat to 75-85℃ and homogenize at 1000-1500 rpm for 4-6 minutes. After homogenization, keep warm for later use to obtain the aqueous phase. Phase A is a humectant and a thickener.

[0037] 2) Mix the components of phase B, heat to 75-85℃, and homogenize at 1000-1500 rpm for 4-6 minutes. After homogenization, keep warm for later use to obtain the oil phase; phase B consists of emulsifier and oil.

[0038] 3) Mix the components of phase C and heat to 55-65℃ to melt; phase C is a preservative.

[0039] 4) Heat the aqueous phase to 75-85℃, add the oil phase at 250-400 rpm, stir and mix. Then cool down to 55-60℃, add the preservative at 250-400 rpm and stir and mix. Then cool down to below 40-45℃, add the composition described in this invention and continue stirring for 5-10 minutes. Finally, add a pH adjuster to adjust the pH to 5.0-6.5, then stop stirring, discharge the material, and obtain the emulsion.

[0040] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0041] The firming and soothing composition containing oxidized resveratrol provided by this invention comprises four components: oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract. The oxidized resveratrol particles are obtained by loading oxidized resveratrol onto lignin, which greatly improves the photostability of oxidized resveratrol. Furthermore, the particles are rationally combined with various firming and anti-aging ingredients. Through the synergistic effect of the above four components, the composition can achieve firming and anti-aging effects from multiple aspects, including promoting collagen and elastin production, inhibiting decomposition, and accelerating cell renewal. Detailed Implementation

[0042] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0043] Lignin, purchased from Shandong Longli Biotechnology Co., Ltd.;

[0044] Oxidized resveratrol was purchased from Naturalis Srl, under the product name OXYRESVERATROL;

[0045] The extract of Edelweiss from the mountains was purchased from Guangzhou Chennuo Biotechnology Co., Ltd., and its product name is Edelweiss Extract.

[0046] The yarrow extract was purchased from Shaanxi Kangduopu Biotechnology Co., Ltd., and its product name is yarrow extract.

[0047] The Artemisia capillaris extract was purchased from Xi'an Yijun Biotechnology Co., Ltd., and its product name is Artemisia capillaris extract.

[0048] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0049] Example 1

[0050] Oxidized resveratrol and lignin were prepared at a mass ratio of 1:2 and dissolved in ethanol (analytical grade) to a concentration of 0.5 mg / mL. The solution was stirred for 1 hour and filtered to remove insoluble matter, resulting in a filtered solution system. Using a magnetic stirrer, 7 times the weight of deionized water was added dropwise to the filtered solution system and stirred continuously for 5 minutes to obtain a suspension in which lignin particles loaded with oxidized resveratrol were stably dispersed in the aqueous phase. Hereinafter, this suspension will be referred to as "oxidized resveratrol particles".

[0051] Example 2

[0052] Oxidized resveratrol and lignin were prepared at a mass ratio of 1:3.5 and dissolved in ethanol (analytical grade) to a concentration of 1 mg / mL. The solution was stirred for 1 hour and filtered to remove insoluble matter, resulting in a filtered solution system. Using a magnetic stirrer, 8 times the weight of deionized water was added dropwise to the filtered solution system and stirred continuously for 8 minutes to obtain oxidized resveratrol granules.

[0053] Example 3

[0054] Oxidized resveratrol and lignin were prepared into a 1 mg / mL solution using ethanol (analytical grade) at a mass ratio of 1:5. The solution was stirred and dissolved for 2 hours, and the insoluble matter was removed by filtration to obtain the filtered solution system. Deionized water with a weight of 9 times that of the filtered solution system was added dropwise using a magnetic stirrer at high speed, and the mixture was stirred continuously for 10 minutes to obtain oxidized resveratrol granules.

[0055] Comparative Example 1

[0056] Oxidized resveratrol and lignin were prepared into a 1 mg / mL solution using ethanol (analytical grade) at a mass ratio of 1:6. The solution was stirred and dissolved for 1 hour, and then filtered to remove insoluble matter, resulting in a filtered solution system. Using a magnetic stirrer, 8 times the weight of deionized water was added dropwise to the filtered solution system, and stirring was continued for 8 minutes to obtain oxidized resveratrol granules.

[0057] Comparative Example 2

[0058] Oxidized resveratrol and lignin were prepared into a 1 mg / mL solution using ethanol (analytical grade) at a mass ratio of 1:1. The solution was stirred and dissolved for 1 hour, and the insoluble matter was removed by filtration to obtain the filtered solution system. The solution system was stirred at high speed with a magnetic stirrer, and 8 times the weight of deionized water was added dropwise to the filtered solution system. The mixture was stirred continuously for 8 minutes to obtain oxidized resveratrol granules.

[0059] Comparative Example 3

[0060] Oxidized resveratrol and lignin were prepared at a mass ratio of 1:3.5 and dissolved in ethanol (analytical grade) to a concentration of 2 mg / mL. The solution was stirred for 1 hour and filtered to remove insoluble matter, resulting in a filtered solution system. Using a magnetic stirrer, 8 times the weight of deionized water was added dropwise to the filtered solution system and stirred continuously for 8 minutes to obtain oxidized resveratrol granules.

[0061] Comparative Example 4

[0062] Oxidized resveratrol and lignin were prepared in a mass ratio of 1:3.5 and dissolved in acetone (analytical grade) to a concentration of 1 mg / mL. The solution was stirred for 1 hour and filtered to remove insoluble matter, resulting in a filtered solution system. Using a magnetic stirrer, 8 times the weight of deionized water was added dropwise to the filtered solution system and stirred continuously for 8 minutes to obtain oxidized resveratrol granules.

[0063] Test Example 1: Photostability Test of Oxidized Resveratrol Particles

[0064] The photostability of oxidized resveratrol particles prepared in Examples 1-3 and Comparative Examples 1-4, and untreated oxidized resveratrol, was determined using the following methods:

[0065] Untreated oxidized resveratrol powder, oxidized resveratrol particles prepared in Examples 1-3 and Comparative Examples 1-4 were irradiated under 365 nm light for 2 h. The content of oxidized resveratrol in different samples before and after irradiation was tested by HPLC, and the degradation rate of oxidized resveratrol was calculated. The degradation rate of oxidized resveratrol % = (content of oxidized resveratrol before irradiation - content of oxidized resveratrol after irradiation) / content of oxidized resveratrol before irradiation * 100%.

[0066] Test results:

[0067] The test data are shown in Table 1. In Examples 1-3, the degradation rate of resveratrol oxidized in Examples 1-3 was reduced by 86.82%-91.83% compared to untreated resveratrol oxidized powder, indicating that lignin-loaded resveratrol oxidized can significantly improve the photostability of resveratrol oxidized. Furthermore, this invention also screened the condition parameters in the preparation method of resveratrol oxidized particles. Specifically, the difference between Comparative Examples 1-2 and Example 2 lies in the different mass ratios of resveratrol oxidized to lignin; in Comparative Example 3, the solution concentration was different; and in Comparative Example 4, the solvent used was different. Comparing the test data of Example 2 and Comparative Examples 1-4 shows that in the preparation of resveratrol oxidized particles, using resveratrol oxidized and lignin within a specific mass ratio range as raw materials, and using ethanol to dissolve and prepare solutions within a specific concentration range, can greatly reduce the degradation rate of resveratrol oxidized. This may be related to the loading effect of lignin and the stability of the particles. The results show that the lignin-loaded oxidized resveratrol particles prepared by the preparation method provided in the embodiments of the present invention can significantly improve the photostability of oxidized resveratrol, and the oxidized resveratrol particles prepared in Example 2 have the best effect. Therefore, this particle was selected to prepare the composition in the future.

[0068] Table 1 Degradation rate of resveratrol oxide particles

[0069]

[0070]

[0071] Application Example 1-4 and Comparative Application Example 1-6

[0072] (1) Using the oxidized resveratrol particles prepared in Example 2, compositions were prepared according to the formulations in Table 2 to obtain the compositions of Application Examples 1-4 and Comparative Application Examples 1-6.

[0073] Table 2. Components and dosages in the composition

[0074]

[0075]

[0076] Note: "-" indicates no additives; and the total mass of the composition is the same in different application examples.

[0077] (2) Using the compositions of Application Examples 1-4 and Comparative Application Examples 1-6, soothing and repairing products were prepared according to the composition in Table 3, respectively, to obtain emulsions corresponding to Application Examples 1-4 and Comparative Application Examples 1-6. The preparation process of the emulsions specifically includes the following steps:

[0078] 1) Pretreatment of the compositions corresponding to Examples 1-4 and Comparative Application Examples 1-6: First, weigh the corresponding mass of each component according to the formula in Table 2 (the total mass of the composition is the same in different application examples); if the formula contains oxidized resveratrol particles, disperse the oxidized resveratrol particles in 10 times the mass of the composition in water, then add the other components in the composition, mix and stir to dissolve; if the formula does not contain oxidized resveratrol particles, directly mix the components in the composition and add 10 times the mass of the composition in water, stir and dissolve to obtain the composition pretreatment solution;

[0079] 2) Mix each component of phase A with an appropriate amount of water and stir. Heat to 80°C and homogenize at 1200 rpm for 5 minutes. After homogenization, keep warm for later use to obtain the aqueous phase.

[0080] 3) Mix the components of phase B, heat to 80°C, and homogenize at 1200 rpm for 5 minutes. After homogenization, keep warm for later use to obtain the oil phase.

[0081] 4) Mix the components of phase C and heat to 60°C to melt them, thus obtaining the preservative;

[0082] 5) Heat the aqueous phase to 80°C, add the oil phase at 300 rpm, stir and mix. Then cool down to 60°C, add the preservative at 300 rpm and stir and mix. Then cool down to below 45°C, add the pretreatment solutions of the above-mentioned compositions respectively and continue stirring for 5 minutes. Finally, add arginine to adjust the pH to 5.0-6.5, stop stirring, discharge the material, and obtain the emulsion.

[0083] Table 3. Components in Soothing and Repairing Products

[0084]

[0085]

[0086] Test Example 2: Determination of the effect of the composition on collagen I and elastin content

[0087] The compositions of Application Examples 1-4 and Comparative Application Examples 1-6 were used as test samples to determine their effects on collagen I and elastin content. The method is as follows:

[0088] Human dermal fibroblasts (HSFs) were seeded in 96-well cell culture plates at a density of 2000 cells / well. Each well was treated with 100 μL of DMEM + 10% fetal bovine serum (FBS) + 1% penicillin / streptomycin medium, and cultured for 24 h. The cells were then separated into a control group and an experimental group. The control group received 100 μL of DMEM medium. The experimental groups received 100 μL of medium containing 0.1% of the corresponding test sample (the sample was dissolved in DMSO and then diluted with DMEM). After 24 h of culture, cells were collected from each group, the medium was discarded, and the cells were washed twice with PBS. 1 mL of TRIzol lysis buffer was added, cells were scraped, transferred to EP tubes, and stored at -80°C for later use. The levels of type I collagen (ColⅠ) and elastin in HSF cells were detected using a human type I collagen (ColⅠ) ELISA kit (ELISA kit, ml057630) and a human elastin (ELISA kit, ml038411), respectively. The result is expressed as the protein content promotion rate, where the protein content promotion rate = |(protein content)| 实验组 - Protein content 空白组 Protein content 空白组 ×100%.

[0089] Test results:

[0090] The results are shown in Table 4. The type I collagen promotion rate of Application Examples 1-4 reached 188.29%-218.14%, and the elastin promotion rate reached 115.04%-133.67%, indicating that the composition provided by the present invention can significantly promote the synthesis of type I collagen and elastin. Comparing Application Example 2 with Comparative Examples 1-3, it can be seen that the composition lacking 1-2 of the components significantly reduces the promotion rates of type I collagen and elastin. Comparing Application Example 2 with Comparative Examples 4-5, it can be seen that replacing oxidized resveratrol with resveratrol or replacing Edelweiss extract with Scutellaria baicalensis extract in the composition, where resveratrol is a natural polyphenol, a potent antioxidant and anti-inflammatory compound, and can also enhance collagen synthesis, has a certain firming effect; and Scutellaria baicalensis extract has anti-aging, firming, and skin-soothing effects, the composition provided in Comparative Examples 4-5 also shows significantly lower promotion rates of type I collagen and elastin than the composition provided in Application Example 2 of this invention. Based on the above results, it is evident that the combination of oxidized resveratrol particles, Edelweiss extract, Yarrow extract, and Artemisia capillaris extract in the composition of this invention can produce a synergistic effect. A comparison of Application Example 6 with Application Examples 1-4 shows that the ratio of different components also has a significant impact on increasing the content of type I collagen and elastin in the composition.

[0091] Table 4 Results of the promotion rate of type I collagen and elastin content

[0092] Group Type I collagen promotion rate (%) Elastin promotion rate (%) Application Example 1 195.38 115.04 Application Example 2 218.14 133.67 Application Example 3 207.65 128.25 Application Example 4 188.29 119.89 Comparative Application Example 1 85.73 49.16 Comparative Application Example 2 76.97 35.52 Comparative Application Example 3 101.82 58.30 Comparative Application Example 4 93.58 52.37 Comparative Application Example 5 77.21 30.93 Comparative Application Example 6 116.46 74.21

[0093] Test Example 3: Skin Firming, Soothing, and Repairing Effects Test

[0094] The emulsions prepared using Application Examples 1-4 and Comparative Application Examples 1-6 were used as test samples to test their skin firming, soothing, and repairing effects. The methods are as follows:

[0095] (1) One hundred volunteers aged 18-45 were selected and randomly divided into 10 groups of 10 each. During the test, each group randomly used the lotions from Application Examples 1-4 and Comparative Application Examples 1-6 of this invention, applying them once in the morning and once in the evening. The method of application was to take 1g of the sample and apply it evenly to the entire face after cleansing and moisturizing, gently massaging until fully absorbed. Follow-up visits were conducted on days 0 and 7 to test various indicators.

[0096] (2) On days 0 and 7 of the follow-up visit, subjects did not apply any skincare products. After cleansing, they sat quietly for 30 minutes in a constant temperature and humidity room with a temperature of 21±1℃ and a humidity of 50±10%. A skin elasticity tester and a transdermal moisture loss probe were used. TM Hex (Courage+Khazaka) and Moisture Probe The CM 825 (Courage+Khazaka) test measured the initial skin elasticity coefficient R2, skin firmness F4, and TEWL values ​​of the subjects after facial cleansing. The Visia-7 was used to take facial photos, and the exported red area images were analyzed to obtain the initial a* value.

[0097] (3) Analyze the improvement of each indicator, and take the average value of the data. The improvement is calculated as follows:

[0098] Improvement rate (%) = |(X) 使用后 -X 使用前 ) / X 使用前 ×100%|;

[0099] In the formula:

[0100] X 使用前 Data on various indicators tested before subjects used the product;

[0101] X 使用后 Data on various indicators for subjects before they use the product.

[0102] Test results:

[0103] The results are shown in Table 5. From the improvement rates of R2, F4, TEWL, and a values ​​in the application examples, it can be seen that the emulsion prepared by the composition provided by the present invention has significant effects in improving skin elasticity, firming the skin, moisturizing, and soothing redness. Comparing the test results of the application examples and the application comparison examples, it can be seen that the emulsion prepared by the composition provided by the present invention has better effects in improving skin elasticity, firming, moisturizing, and soothing. This indicates that the components of the composition with the specific ratio of the present invention have a synergistic effect and can synergistically improve the effects of the composition in terms of skin firming, soothing, and repair.

[0104] Table 5. Results of Skin Firming, Soothing, and Repairing Effects Test

[0105] Group R2 improvement rate (%) F4 value improvement rate (%) TEWL value improvement rate (%) Improvement rate of a value (%) Application Example 1 11.9 22.5 11.6 7.2 Application Example 2 13.6 25.8 13.5 7.9 Application Example 3 12.9 24.7 12.8 6.8 Application Example 4 11.2 21.4 12.1 7.1 Comparative Application Example 1 4.4 9.9 8.3 4.0 Comparative Application Example 2 3.7 8.6 6.8 3.8 Comparative Application Example 3 5.9 11.3 6.4 4.4 Comparative Application Example 4 5.1 10.5 7.2 3.6 Comparative Application Example 5 3.3 7.7 8.0 4.3 Comparative Application Example 6 6.8 13.9 9.6 4.7

[0106] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A firming and soothing composition containing oxidized resveratrol, characterized in that, It includes oxidized resveratrol particles, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-2):(1-5):(0.01-2):(0.01-2); the oxidized resveratrol particles are obtained by loading oxidized resveratrol onto lignin as a carrier.

2. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, It includes oxidized resveratrol granules, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-1):(1-3.5):(0.01-1):(0.01-1).

3. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, It includes oxidized resveratrol granules, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.1-1):(2-3.5):(0.2-1):(0.2-1).

4. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, The preparation method of the oxidized resveratrol particles includes the following steps: S1. Take resveratrol oxide and lignin in a mass ratio of 1:2-5, use ethanol as solvent, prepare a solution with a concentration of 0.5-1 mg / mL, stir for 1-2 h, remove insoluble matter, and obtain the solution system; S2. While stirring, add deionized water dropwise, equivalent to 7-9 times the weight of the solution system, and continue stirring for 5-10 minutes to obtain oxidized resveratrol granules.

5. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, In step S1, the mass ratio of oxidized resveratrol to lignin is 1:2-3.

5.

6. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, In step S1, the concentration of the prepared solution is 1 mg / mL.

7. The use of the firming and soothing composition containing oxidized resveratrol according to any one of claims 1-6 in the preparation of firming and anti-aging cosmetics.

8. The application as described in claim 7, characterized in that, The firming and soothing composition containing oxidized resveratrol accounts for 1-5% of the total mass of the cosmetic.

9. The application as described in claim 7, characterized in that, The cosmetics mentioned are toners, lotions, creams, masks, serums, or sprays.

10. An emulsion, characterized in that, The composition comprises the following ingredients by weight percentage: 1-5% of the firming and soothing composition containing oxidized resveratrol as described in any one of claims 1-6, 3-4% of moisturizer, 0.1-0.5% of thickener, 0.5-2.5% of emulsifier, 4.5-6.5% of oil, 0.5-3% of preservative, 0.1-0.5% of pH adjuster, and the balance being water.

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