Composition for treating hyperlipemia and hyperglycemia and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and discloses a composition for treating hyperlipemia and hyperglycemia and a preparation method thereof, and the composition is prepared from the following raw materials in parts by weight: 10-28 parts of purslane, 10-25 parts of pawpaw, 5-12 parts of rhizoma polygonati, 5-10 parts of valeriana jatamansi jones, 0.5-3 parts of illicium verum, 0.5-4 parts of pseudo-ginseng, 1-5 parts of hawthorn and 2-8 parts of Pu'er tea. The preparation method comprises the following steps: S1, weighing the raw materials and crushing; s2, performing water extraction on the crushed purslane, pawpaw, illicium verum, hawthorn and Pu'er tea twice to obtain an extract; s3, firstly extracting the crushed valeriana jatamansi jones and rhizoma polygonati with ethanol, and then extracting with ethyl acetate to obtain an extract; and S4, merging the crushed pseudo-ginseng, the extract obtained in S2 and the extract obtained in S3, and uniformly mixing to obtain the composition for treating hyperlipemia and hyperglycemia. The composition disclosed by the invention has obvious effects of reducing blood fat and reducing blood sugar.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical technology, specifically relating to a composition for treating hyperlipidemia and hyperglycemia and its preparation method. Background Technology

[0002] Hyperlipidemia, also known as high blood lipids or dyslipidemia, typically refers to elevated levels of triglycerides (TG) and / or total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-C), and decreased high-density lipoprotein cholesterol (HDL-C) in blood plasma. Hyperlipidemia is closely associated with various diseases such as atherosclerosis, coronary heart disease, and stroke. In recent years, blood lipid levels in the Chinese population have risen significantly, and the prevalence of dyslipidemia has been increasing year by year. Currently, statins are commonly used in clinical practice to lower cholesterol, but their efficacy is limited. Clinically, there is a need to optimize lipid-lowering strategies and explore more comprehensive lipid-lowering drugs.

[0003] Hyperglycemia refers to an abnormally high concentration of glucose in the blood, usually caused by insufficient insulin secretion, insulin resistance, or other metabolic abnormalities. Long-term hyperglycemia can lead to diabetes and its complications, causing damage to related organs, such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diabetic foot.

[0004] Currently, most drugs used in clinical treatment of hyperlipidemia and hyperglycemia are Western medicines, and their effects are mostly limited. Summary of the Invention

[0005] One of the technical problems to be solved by the present invention is to provide a composition for treating hyperlipidemia and hyperglycemia, so as to improve the effects of lowering blood lipids and lowering blood sugar.

[0006] To solve the above-mentioned technical problems, the technical solution of the present invention is as follows:

[0007] A composition for treating hyperlipidemia and hyperglycemia, comprising, by weight, the following ingredients: 10-28 parts purslane, 10-25 parts papaya, 5-12 parts polygonatum, 5-10 parts spider lily, 0.5-3 parts star anise, 0.5-4 parts notoginseng, 1-5 parts hawthorn, and 2-8 parts Pu-erh tea.

[0008] In the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, preferably, by weight, it is composed of the following raw materials: 15-22 parts of purslane, 13-20 parts of papaya, 5-8 parts of polygonatum, 5-8 parts of spider lily, 1-2 parts of star anise, 1-3 parts of notoginseng, 3-5 parts of hawthorn and 2-5 parts of Pu-erh tea.

[0009] In the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, it is further preferably composed of the following raw materials in parts by weight: 20 parts purslane, 16 parts papaya, 7 parts polygonatum, 7 parts spider lily, 1 part star anise, 2 parts notoginseng, 4 parts hawthorn and 2 parts Pu-erh tea.

[0010] More preferably, the composition for treating hyperlipidemia and hyperglycemia provided by the present invention comprises, by weight, the following raw materials: 10-28 parts of purslane, 10-25 parts of papaya, 5-12 parts of polygonatum, 5-10 parts of spider lily, 0.5-3 parts of star anise, 0.5-4 parts of notoginseng, 1-5 parts of hawthorn, 2-8 parts of Pu-erh tea, and 3-8 parts of cloves.

[0011] Another aspect of the present invention provides a method for preparing a composition for treating hyperlipidemia and hyperglycemia, comprising the following steps:

[0012] S1. Weigh the following ingredients by weight: purslane 10-28 parts, papaya 10-25 parts, polygonatum 5-12 parts, spider lily 5-10 parts, star anise 0.5-3 parts, notoginseng 0.5-4 parts, hawthorn 1-5 parts, and Pu-erh tea 2-8 parts.

[0013] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0014] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 75-90% ethanol, heat and reflux for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat and reflux for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, crush to obtain the third extract;

[0015] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0016] In the preparation method of the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, preferably, in step S1, 3 to 8 parts by weight of cloves are weighed and pulverized.

[0017] In the preparation method of the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, it is even more preferably that the pulverized cloves are treated in the same way as the raw materials in step S2.

[0018] In the preparation method of the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, more preferably, the ethanol concentration in step S3 is 85% Vol.

[0019] In the preparation method of the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, it is further preferred that the temperature of adding ethanol and heating and refluxing for extraction in step S3 is 65-72°C.

[0020] In the preparation method of the composition for treating hyperlipidemia and hyperglycemia provided by the present invention, more preferably, the heating reflux extraction temperature for adding ethyl acetate in step S3 is 68-75°C.

[0021] Purslane is the dried aerial part of *Portulaca oleracea* L., a plant in the Portulacaceae family. It is harvested in summer and autumn, after which residual roots and impurities are removed, the plant is washed, slightly steamed or scalded, and then sun-dried. It is sour and cold in nature. It enters the liver and large intestine meridians. It clears heat and detoxifies, cools the blood and stops bleeding, and stops dysentery. It is used for dysentery due to heat toxins, carbuncles and boils, eczema, erysipelas, snake and insect bites, hematochezia, hemorrhoidal bleeding, and metrorrhagia.

[0022] Papaya is the dried, nearly mature fruit of *Chaenomeles speciosa* (Sweet) Nakai, a plant in the Rosaceae family. It is harvested in summer and autumn when the fruit is greenish-yellow, scalded in boiling water until the outer skin turns grayish-white, then longitudinally split in half and sun-dried. It is sour and warm in nature. It enters the liver and spleen meridians. It relaxes muscles and tendons, harmonizes the stomach, and resolves dampness. It is used for damp-bi syndrome with contractures, lower back and knee pain, summer-heat vomiting and diarrhea, muscle spasms and pain, and beriberi with edema.

[0023] Polygonatum is the dried rhizome of *Polygonatum kingianum* Coll. et Hemsl., *Polygonatum sibiricum* Red., or *Polygonatum cyrtonema* Hua, all belonging to the Liliaceae family. Depending on its shape, it is commonly known as "Large Polygonatum," "Chicken Head Polygonatum," or "Ginger-shaped Polygonatum." It is harvested in spring and autumn, the fibrous roots are removed, it is washed, briefly blanched in boiling water or steamed until thoroughly cooked, and then dried. It is sweet and neutral in nature. It enters the spleen, lung, and kidney meridians. It tonifies qi and nourishes yin, strengthens the spleen, moistens the lungs, and benefits the kidneys. It is used for spleen and stomach qi deficiency, fatigue, stomach yin deficiency, dry mouth and poor appetite, lung deficiency and dry cough, consumptive cough with hemoptysis, deficiency of essence and blood, soreness and weakness of the lower back and knees, premature graying of hair, and internal heat and thirst.

[0024] Spider-scented rhizome and root of *Vaieriana jatamansi* Jones, a plant in the family Vaierianaceae. Harvested in autumn, the roots and soil are removed, and then dried. Slightly bitter, pungent, and warm in nature. It enters the heart, spleen, and stomach meridians. It regulates qi and relieves pain, promotes digestion and stops diarrhea, dispels wind and dampness, and calms the nerves. It is used for abdominal distension and pain, indigestion, diarrhea and dysentery, rheumatic pain, lower back and knee weakness, and insomnia.

[0025] Star anise is the dried, mature fruit of *Illicium verum* Hook. f., a plant in the Magnoliaceae family. The fruit is harvested in autumn and winter when it turns from green to yellow, and is either briefly blanched in boiling water before drying or dried directly. It is pungent and warm in nature. It enters the liver, kidney, spleen, and stomach meridians. It warms the yang and dispels cold, regulates qi and relieves pain. It is used for abdominal pain due to cold hernia, lower back pain due to kidney deficiency, vomiting due to stomach cold, and cold pain in the epigastrium and abdomen.

[0026] Panax notoginseng is the dried root and rhizome of *Parmx notoginseng* (Burk.) FHChen, a plant belonging to the Araliaceae family. It is harvested in autumn before flowering, washed, and the main root, lateral roots, and rhizome are separated and dried. It is sweet and slightly bitter, and warm in nature. It enters the liver and stomach meridians. It disperses blood stasis, stops bleeding, reduces swelling, and relieves pain. It is used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdominal pain, and swelling and pain from falls.

[0027] Hawthorn is the dried, ripe fruit of *Crataegus pimiatificia* Bge. var. major NEBr. or *Crataegus pinnatifida* Bge., belonging to the Rosaceae family. It is harvested in autumn when the fruit is ripe, sliced, and dried. It is sour, sweet, and slightly warm in nature. It enters the spleen, stomach, and liver meridians. It promotes digestion, strengthens the stomach, regulates qi, disperses blood stasis, and lowers lipids. It is used for food stagnation due to excessive meat consumption, abdominal distension, diarrhea and abdominal pain, amenorrhea due to blood stasis, postpartum blood stasis, stabbing pain in the heart and abdomen, chest pain, hernia pain, and hyperlipidemia. Roasted hawthorn has enhanced digestive and stagnation-relieving effects. It is used for food stagnation due to excessive meat consumption and incomplete diarrhea.

[0028] Clove is the dried flower bud of *Eugenia caryophyllata* Thunb., a plant in the Myrtaceae family. It is harvested when the buds turn from green to red and then dried. It is pungent and warm in nature. It enters the spleen, stomach, lung, and kidney meridians. It warms the middle jiao (spleen and stomach) and relieves nausea and vomiting, tonifies the kidneys and strengthens yang. It is used for spleen and stomach deficiency-cold, hiccups and vomiting, poor appetite and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency.

[0029] Using the above technical solution, the combination of purslane, papaya, polygonatum, spider lily, star anise, notoginseng, hawthorn, and Pu-erh tea, along with an effective extraction method, results in a composition that significantly lowers blood lipids and blood sugar. The addition of cloves to the composition further enhances these effects. Attached Figure Description

[0030] Figure 1 The changes in TC, TG, LDL-C and HDL-C in rats after the establishment of a hyperlipidemia model;

[0031] Figure 2 The effects of the compositions obtained in each example on TC, TG, LDL-C and HDL-C in rats;

[0032] Figure 3 The hypoglycemic effect of the compositions obtained in each example on normal rats;

[0033] Figure 4 The effects of the compositions obtained in each example on blood glucose levels in hyperglycemic model rats are shown. Detailed Implementation

[0034] The specific embodiments of the present invention will be further described below with reference to the accompanying drawings. It should be noted that these descriptions are for the purpose of aiding understanding the present invention, but do not constitute a limitation thereof. Furthermore, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0035] Example 1

[0036] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following raw materials: 28 parts purslane, 10 parts papaya, 12 parts polygonatum, 10 parts spider lily, 0.5 parts star anise, 0.5 parts notoginseng, 5 parts hawthorn, and 8 parts Pu-erh tea.

[0037] Its preparation method includes the following steps:

[0038] S1. Weigh the above raw materials according to the weight proportions;

[0039] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0040] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 90% ethanol, heat to 72°C and reflux for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to 68°C and reflux for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, crush to obtain the third extract;

[0041] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0042] Example 2

[0043] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following ingredients: 10 parts purslane, 25 parts papaya, 5 parts polygonatum, 5 parts spider lily, 3 parts star anise, 4 parts notoginseng, 1 part hawthorn, and 2 parts Pu-erh tea.

[0044] Its preparation method includes the following steps:

[0045] S1. Weigh the above raw materials according to the weight proportions;

[0046] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0047] S3. Add the crushed spider lily and polygonatum to a reflux extraction apparatus, add 75% ethanol, heat to reflux at 65°C for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to reflux at 75°C for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, crush to obtain the third extract;

[0048] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0049] Example 3

[0050] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following ingredients: 15 parts purslane, 20 parts papaya, 5 parts polygonatum, 8 parts spider venom, 2 parts star anise, 3 parts notoginseng, 5 parts hawthorn, and 2 parts Pu-erh tea.

[0051] Its preparation method includes the following steps:

[0052] S1. Weigh the above raw materials according to the weight proportions;

[0053] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0054] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 78% ethanol, heat to 69°C and reflux for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to 70°C and reflux for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, crush to obtain the third extract;

[0055] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0056] Example 4

[0057] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following ingredients: 22 parts purslane, 13 parts papaya, 8 parts polygonatum, 5 parts spider lily, 1 part star anise, 1 part notoginseng, 3 parts hawthorn, and 5 parts Pu-erh tea.

[0058] Its preparation method includes the following steps:

[0059] S1. Weigh the above raw materials according to the weight proportions;

[0060] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0061] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 82% ethanol, heat to reflux at 71°C for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to reflux at 72°C for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, crush to obtain the third extract;

[0062] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0063] Example 5

[0064] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following ingredients: 20 parts purslane, 16 parts papaya, 7 parts polygonatum, 7 parts spider lily, 1 part star anise, 2 parts notoginseng, 4 parts hawthorn, and 2 parts Pu-erh tea.

[0065] Its preparation method includes the following steps:

[0066] S1. Weigh the above raw materials according to the weight proportions;

[0067] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0068] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 85% ethanol, heat to reflux at 70°C for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to reflux at 69°C for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, crush to obtain the third extract;

[0069] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0070] Example 6

[0071] This embodiment provides a composition for treating hyperlipidemia and hyperglycemia, which, by weight, consists of the following raw materials: 20 parts purslane, 16 parts papaya, 7 parts polygonatum, 7 parts spider lily, 1 part star anise, 2 parts notoginseng, 4 parts hawthorn, 2 parts Pu-erh tea, and 4 parts cloves.

[0072] Its preparation method includes the following steps:

[0073] S1. Weigh the above raw materials according to the weight proportions;

[0074] S2. Put the crushed purslane, papaya, star anise, hawthorn, Pu-erh tea and cloves into a container, add water, decoct, and filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, and filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract;

[0075] S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 85% ethanol, heat to reflux at 70°C for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to reflux at 69°C for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, crush to obtain the third extract;

[0076] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

[0077] Comparative Example 1

[0078] This comparative example provides a composition, by weight, consisting of the following ingredients: 20 parts purslane, 16 parts papaya, 7 parts spider lily, 1 part star anise, 2 parts Panax notoginseng, 4 parts hawthorn, and 2 parts Pu-erh tea.

[0079] Its preparation method includes the following steps:

[0080] S1. Weigh the above raw materials according to the weight proportions;

[0081] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0082] S3. The crushed spider venom was placed into a reflux extraction device, 85% ethanol was added, and the mixture was heated to reflux at 70°C for 2 hours. The residue and the liquid were filtered to obtain the third residue and the third liquid. The liquid was distilled under reduced pressure and concentrated to dryness to obtain the second extract. The residue was placed into a reflux extraction device, ethyl acetate was added, and the mixture was heated to reflux at 69°C for 1 hour. The mixture was filtered to obtain the fourth liquid and the fourth residue. The liquid was concentrated under reduced pressure and dried to dryness, and then crushed to obtain the third extract.

[0083] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain the composition.

[0084] Comparative Example 2

[0085] This comparative example provides a composition, by weight, consisting of the following ingredients: 20 parts purslane, 16 parts papaya, 7 parts polygonatum, 1 part star anise, 2 parts notoginseng, 4 parts hawthorn, and 2 parts Pu-erh tea.

[0086] Its preparation method includes the following steps:

[0087] S1. Weigh the above raw materials according to the weight proportions;

[0088] S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract.

[0089] S3. Add the pulverized Polygonatum sibiricum to a reflux extraction apparatus, add 85% Vol ethanol, heat to reflux at 65-72℃ for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat to reflux at 68-75℃ for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, pulverize, and obtain the third extract;

[0090] S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain the composition.

[0091] Test case

[0092] 1. Lipid-lowering effect test

[0093] Experimental animals: SPF grade rats, male, 200±20g / rat, 100 rats in total.

[0094] Rats were acclimatized to a maintenance diet for 5 days, then randomly divided into two groups: a control group of 10 rats and a model group of 90 rats. The control group received a maintenance diet, while the model group received a model diet (maintenance diet supplemented with 20.0% sucrose, 15.0% lard, 1.2% cholesterol, and 0.2% sodium cholate). After 2 weeks of feeding without fasting, blood was collected from the tail. Serum was separated, and serum TC, TG, LDL-C, and HDL-C levels were measured using a kit. Compared with the control group, the model group showed significant increases in TC, TG, and LDL-C, indicating successful model establishment. Results are shown in Table 1 and [Table data missing]. Figure 1 .

[0095] Table 1. Changes in TC, TG, LDL-C and HDL-C in rats after modeling ( ±s)

[0096]

[0097] From Table 1 and Figure 1It can be seen that after modeling, compared with the blank control group, TC, TG and LDL-C were significantly increased in the model group, indicating that the modeling was successful.

[0098] After successful modeling, the model group was randomly divided into 9 groups of 10 animals each: model control group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Example 6 group, Comparative Example 1 group, and Comparative Example 2 group. No significant differences were found in TC, TG, LDL-C, and HDL-C among the 9 model groups. The blank control group continued to receive a maintenance diet, while the model groups continued to receive a model diet (maintenance diet supplemented with 20.0% sucrose, 15.0% lard, 1.2% cholesterol, and 0.2% sodium cholate).

[0099] Administration: The blank control group and the model control group were given 2 mL of physiological saline once daily by gavage for 30 days. Groups 1, 2, 3, 4, 5, 6, Comparative Example 1, and Comparative Example 2 were given 40 mg of the composition obtained in Examples 1, 2, 3, 4, 5, 6, Comparative Example 1, and Comparative Example 2, respectively, dissolved in physiological saline and administered by gavage once daily for 30 days. At the end of the experiment, blood was collected from the tail end without fasting. Serum was separated, and serum TC, TG, LDL-C, and HDL-C levels were measured using a kit. The results are shown in Table 2 and... Figure 2 .

[0100] Table 2. Effects of the compositions obtained in each example on TC, TG, LDL-C and HDL-C in rats ( (±s, n=10)

[0101]

[0102] From Table 2 and Figure 2 As can be seen, compared with the model control group, the contents of TC, TG, and LDL-C in Examples 1 to 6, Comparative Example 1, and Comparative Example 2 were significantly reduced, and the contents of TC, TG, and LDL-C in Comparative Example 1 and 2 were higher than those in Examples 1 to 6. Therefore, the compositions obtained in Examples 1 to 6 have a significant effect on reducing the contents of TC, TG, and LDL-C.

[0103] 2. Hypoglycemic effect test

[0104] 2.1 Hypoglycemic test in normal rats

[0105] Experimental animals: SPF grade rats, male, 180±20g / rat, 90 rats in total.

[0106] Rats were acclimatized to a maintenance diet for 5 days and then randomly divided into a blank control group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Example 6 group, Comparative Example 1 group, and Comparative Example 2 group, with 10 rats in each group. After fasting for 3–5 hours, tail blood was collected, and blood glucose levels were measured using a glucometer. Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Example 6 group, Comparative Example 1 group, and Comparative Example 2 group were administered 40 mg of the composition obtained in Examples 1, 2, 3, 4, 5, 6, Comparative Example 1, and Comparative Example 2, respectively, dissolved in physiological saline and administered by gavage for 30 days, once daily. After fasting for 3–5 hours, tail blood was collected, and blood glucose levels were measured using a glucometer. The results are shown in Table 3. Figure 3 .

[0107] Table 3. Hypoglycemic effect of the compositions obtained in each example on normal rats ( (±s, n=10)

[0108]

[0109] From Table 3 and Figure 3 It can be seen that there was no significant difference in the initial blood glucose value and the blood glucose value 30 days after administration among the groups.

[0110] 2.2 Hypoglycemic test of a hyperglycemic model with pancreatic islet damage

[0111] Experimental animals: SPF grade rats, male, 180±20g / rat, 90 rats in total.

[0112] Rats were acclimatized to a maintenance diet for 5 days, then fasted for 4 hours, and fasting blood glucose was measured to determine the baseline blood glucose level for this batch of rats. Subsequently, the rats were fasted for 24 hours (with free access to water) and injected with alloxan at 150 mg / kg BW.ip to induce a hyperglycemic model. Seven days later, after a 4-hour fast, blood glucose was measured again; a blood glucose level of 10–25 mmol / L indicated a successful hyperglycemic model. The results are shown in Table 4.

[0113] Table 4. Rat model establishment ( (±s, n=90)

[0114]

[0115] As shown in Table 4, the blood glucose level of rats on day 7 of modeling was significantly higher than that of rats at baseline, at 17.23±3.53 mmol / L, with the blood glucose level ranging from 10 to 25 mmol / L, indicating that the hyperglycemia model was successful.

[0116] Rats were then randomly divided into 9 groups of 10 rats each: model control group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Example 6 group, Comparative Example 1 group, and Comparative Example 2 group. The model control group was given physiological saline. Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Example 6 group, Comparative Example 1 group, and Comparative Example 2 group were given 40 mg of the composition obtained in Examples 1, 2, 3, 4, 5, 6, Comparative Example 1, and Comparative Example 2, respectively, dissolved in physiological saline and administered by gavage for 30 days, once daily. After fasting for 3–5 hours, tail blood was collected, and blood glucose was measured using a glucometer. The percentage decrease in blood glucose was calculated. The results are shown in Table 5. Figure 4 .

[0117] Table 5. Effects of the compositions obtained in each example on blood glucose levels in hyperglycemic model rats ( (±s, n=10)

[0118]

[0119] From Table 5 and Figure 4 It can be seen that the blood glucose levels in Examples 1 to 6, Comparative Example 1, and Comparative Example 2 were significantly lower than those in the model control group. The blood glucose reduction rate in Examples 1 to 6 was higher than 56.75%, while the blood glucose reduction rates in Comparative Examples 1 and 2 were significantly lower than those in Examples 1 to 6. Therefore, the compositions obtained in Examples 1 to 6 have a significant blood glucose-lowering effect.

[0120] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. For those skilled in the art, various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and these variations still fall within the protection scope of the present invention.

Claims

1. A composition for treating hyperlipidemia and hyperglycemia, characterized in that, By weight, it consists of the following ingredients: purslane 10-28 parts, papaya 10-25 parts, polygonatum 5-12 parts, spider lily 5-10 parts, star anise 0.5-3 parts, notoginseng 0.5-4 parts, hawthorn 1-5 parts, and Pu-erh tea 2-8 parts.

2. The composition for treating hyperlipidemia and hyperglycemia according to claim 1, characterized in that, By weight, it consists of the following ingredients: purslane 15-22 parts, papaya 13-20 parts, polygonatum 5-8 parts, spider lily 5-8 parts, star anise 1-2 parts, notoginseng 1-3 parts, hawthorn 3-5 parts, and Pu-erh tea 2-5 parts.

3. The composition for treating hyperlipidemia and hyperglycemia according to claim 2, characterized in that, By weight, it is mainly composed of the following ingredients: purslane 20 parts, papaya 16 parts, polygonatum 7 parts, spider lily 7 parts, star anise 1 part, notoginseng 2 parts, hawthorn 4 parts and Pu-erh tea 2 parts.

4. A composition for treating hyperlipidemia and hyperglycemia, characterized in that, By weight, it consists of the following ingredients: purslane 10-28 parts, papaya 10-25 parts, polygonatum 5-12 parts, spider lily 5-10 parts, star anise 0.5-3 parts, notoginseng 0.5-4 parts, hawthorn 1-5 parts, Pu-erh tea 2-8 parts, and cloves 3-8 parts.

5. A method for preparing a composition for treating hyperlipidemia and hyperglycemia, characterized in that, Includes the following steps: S1. Weigh the following ingredients by weight: purslane 10-28 parts, papaya 10-25 parts, polygonatum 5-12 parts, spider lily 5-10 parts, star anise 0.5-3 parts, notoginseng 0.5-4 parts, hawthorn 1-5 parts, and Pu-erh tea 2-8 parts. S2. Put the crushed purslane, papaya, star anise, hawthorn and Pu-erh tea into a container, add water, decoct, filter to obtain the first decoction and the first dregs; put the first dregs into the container again, add water, decoct, filter to obtain the second decoction and the second dregs; combine the first decoction and the second decoction, distill under reduced pressure, concentrate and dry, crush to obtain the first extract. S3. Add the crushed spider venom and polygonatum to a reflux extraction apparatus, add 75-90% ethanol, heat and reflux for 2 hours, filter to obtain the third residue and the third liquid, distill the third liquid under reduced pressure, concentrate and dry to obtain the second extract; add the third residue to a reflux extraction apparatus, add ethyl acetate, heat and reflux for 1 hour, filter to obtain the fourth liquid and the fourth residue; concentrate the fourth liquid under reduced pressure, dry, crush to obtain the third extract; S4. Combine and mix the pulverized Panax notoginseng, the first extract, the second extract and the third extract evenly to obtain a composition for treating hyperlipidemia and hyperglycemia.

6. The method for preparing the composition for treating hyperlipidemia and hyperglycemia according to claim 5, characterized in that, In step S1, 3 to 8 parts of cloves were weighed and crushed.

7. The method for preparing the composition for treating hyperlipidemia and hyperglycemia according to claim 6, characterized in that, The crushed cloves are processed in the same way as the raw materials in step S2.

8. The method for preparing the composition for treating hyperlipidemia and hyperglycemia according to claim 7, characterized in that, The ethanol concentration mentioned in step S3 is 85% Vol.

9. The method for preparing the composition for treating hyperlipidemia and hyperglycemia according to claim 8, characterized in that, In step S3, the temperature for adding ethanol and heating under reflux for extraction is 65–72°C.

10. The method for preparing the composition for treating hyperlipidemia and hyperglycemia according to claim 9, characterized in that, The heating and reflux extraction temperature for adding ethyl acetate in step S3 is 68–75°C.

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