Liver-protecting and hangover-alleviating formula product and preparation method thereof

Abstract

The invention discloses a liver-protecting and hangover-alleviating formula product and a preparation method thereof, and relates to the technical field of hangover-alleviating products, and the liver-protecting and hangover-alleviating formula product is prepared from the following raw materials by weight: 15-25% of a Pu'er tea extract; 8%-18% of hovenia acerba extract; 6%-15% of a radix puerariae extract; 5%-10% of a corn extract; 10%-20% of high fructose corn syrup; 1.5%-2.0% of malic acid; 10.0%-0.3% of vitamin B; 0.05%-0.2% of vitamin B2; 0.3%-0.7% of compound vitamins; 0.03%-0.08% of a rice bran extract; 2.7 to 5.3 percent of sodium carboxymethyl cellulose; 1.5%-2.3% of magnesium stearate; according to the invention, the Pu'er tea extract is taken as a core and cooperates with the hovenia acerba extract, the radix puerariae extract and other components, so that alcohol metabolism is accelerated by activating acetaldehyde dehydrogenase and ethanol dehydrogenase, the sobering time is shortened, liver cells can be protected, the levels of serum glutamic-pyruvic transaminase and glutamic oxalacetic transaminase are reduced, and the dual effects of dispelling the effects of alcohol and protecting the liver are realized; the limitation that a single component can only promote metabolism in the prior art is solved.

Description

Technical Field

[0001] This invention relates to the field of hangover relief products, specifically a liver-protecting and hangover relief formula product and its preparation method. Background Technology

[0002] Alcohol is a common beverage in social and daily life, and excessive intake can lead to liver damage, gastrointestinal dysfunction, and metabolic imbalance. Long-term consumption may even cause diseases such as fatty liver and cirrhosis. Currently, most hangover remedies on the market are designed based on single plant extracts such as kudzu root and Japanese raisin tree, which accelerate alcohol metabolism by promoting the activity of alcohol dehydrogenase or aldehyde dehydrogenase, but these have significant limitations.

[0003] The problems with existing technologies are: firstly, their mechanisms of action are singular, focusing only on the alcohol metabolism process without involving hepatocyte protection and gut microbiota repair, thus failing to alleviate the chronic damage of alcohol to the liver; secondly, their formulations lack synergy, lacking a scientific ratio of multiple components, making it difficult to form a complete chain of metabolism promotion, damage blocking, and functional repair.

[0004] Furthermore, existing technologies do not adequately address the relationship between gut microbiota and liver metabolism, neglecting the exacerbating effect of alcohol-induced gut microbiota imbalance on liver damage and failing to establish a systematic protective mechanism. Therefore, we propose a liver-protecting and hangover-relieving formula and its preparation method to address the aforementioned problems.

[0005] The information disclosed above in this background section is only for enhancing the understanding of the background section of this invention, and therefore may include prior art that is not known to those skilled in the art. Summary of the Invention

[0006] The purpose of this invention is to provide a liver-protecting and hangover-relieving formula product and its preparation method, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A liver-protecting and hangover-relieving formula product is made from the following raw materials in weight percentages: Pu-erh tea extract 15%-25%; Hovenia dulcis extract 8%-18%; Pueraria lobata extract 6%-15%; Corn extract 5%-10%; Fructose syrup 10%-20%; Malic acid 1.5%-2.0%; Vitamin B1 0.05%-0.3%; Vitamin B2 0.05%-0.2%; Complex vitamins 0.3%-0.7%; Rice bran extract 0.03%-0.08%; Sodium carboxymethyl cellulose 2.7-5.3%; Magnesium stearate 1.5-2.3%;

[0009] Among them, the compound vitamins include vitamin B6, B12, and niacin; the corn extract includes corn peptides; and the Pu-erh tea extract includes theabrownins.

[0010] The preparation method of a liver-protecting, liver-protecting, and hangover-relieving formula product specifically includes the following steps:

[0011] Step 1: Pulverize the Pu-erh tea extract, Hovenia dulcis extract, and Pueraria lobata extract to a particle size of less than 50μm, and sieve them for later use.

[0012] Among them, the supercritical CO2 extraction combined with macroporous resin purification process was used to achieve a purity of more than 95% for theabrownin.

[0013] Step 2: Weigh each raw material according to the weight percentage, add them to the mixer, and mix for 15-30 minutes at a speed of 300-500 r / min to obtain the mixture.

[0014] Step 3: When preparing solid dosage forms, the mixture is granulated using either dry or wet granulation. After granulation, it is dried until the moisture content is less than 5%. The binder for wet granulation is 5-10% starch paste. The dried granules are used to prepare instant powder, tablets with a compression pressure of 20-30 MPa, or granulated granules sieved to 20-40 mesh.

[0015] When preparing the liquid preparation, add the mixture to 50-500ml of purified water, stir to dissolve at 50-60℃, cool, and then fill and sterilize.

[0016] This invention achieves a full-chain intervention—accelerating metabolism, blocking damage, and repairing and protecting—through a scientific ratio of Pu-erh tea extract, Hovenia dulcis extract, Pueraria lobata extract, and functional nutrients.

[0017] Theabrownins, as the core active ingredient, reduce the attack of endotoxins on the liver by regulating the structure of the gut microbiota, thereby reducing the risk of alcoholic liver damage from the source.

[0018] The extracts of Hovenia dulcis and Pueraria lobata synergistically activate the activity of acetaldehyde dehydrogenase and alcohol dehydrogenase, accelerating the decomposition of alcohol and its metabolite acetaldehyde, and significantly improving the metabolic efficiency compared with single components.

[0019] Corn peptides and B vitamins replenish the amino acids and coenzymes needed for alcohol metabolism, alleviating post-drinking energy depletion and metabolic disorders, while reducing gastrointestinal mucosal irritation.

[0020] The synergistic effect of these three ingredients not only shortens the sobering-up time but also lowers serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, achieving the dual effects of sobering up and protecting the liver.

[0021] This invention combines the gut microbiota-regulating effect of theaflavins with liver-protective function, forming a gut-liver axis regulatory mechanism:

[0022] Theabrownins can specifically inhibit alcohol-induced gut microbiota imbalance, reduce intestinal permeability, and decrease endotoxin (LPS) entry into the blood, thereby blocking the activation of the liver TLR4 / NF-κB inflammatory pathway.

[0023] Combined with rice bran extract and malic acid, it further repairs the intestinal barrier function, promotes intestinal peristalsis, reduces the retention time of alcohol in the gastrointestinal tract, and lowers the risk of gastrointestinal mucosal damage. It breaks through the limitations of traditional products that only metabolize but do not protect, achieving proactive prevention and repair of alcohol damage.

[0024] This invention designs differentiated dosage forms for various drinking scenarios, including business banquets, casual drinking, and post-drinking relief. Through process innovation, it enhances practicality and stability. The instant powder form utilizes ultra-fine grinding and dry granulation, improving solubility to complete dissolution within 3 minutes, suitable for rapid pre-drinking consumption to form a protective barrier. The tablet form employs double-layer compression technology; the outer layer rapidly releases Hovenia dulcis extract to block alcohol absorption, while the inner layer slowly releases theaflavins and Pueraria lobata extract, providing sustained liver protection for 6-8 hours, overcoming the shortcomings of traditional products that are fast-acting but short-lasting. The liquid form, through pH adjustment and UHT sterilization, extends shelf life to 12 months while preserving active ingredients. Furthermore, the sweet-acid ratio is adjusted using fructose syrup and malic acid to create a smooth taste that is easily accepted by consumers.

[0025] Compared with the prior art, the beneficial effects of the present invention are:

[0026] This invention uses Pu-erh tea extract as its core ingredient, in combination with other components such as Hovenia dulcis extract and Pueraria lobata extract. It accelerates alcohol metabolism and shortens sobering time by activating acetaldehyde dehydrogenase and alcohol dehydrogenase, while also protecting liver cells and reducing serum alanine aminotransferase and aspartate aminotransferase levels. This achieves a dual effect of sobering up and protecting the liver, overcoming the limitation of existing technologies where a single ingredient can only promote metabolism.

[0027] By utilizing theabrownins to regulate the gut microbiota, inhibit the proliferation of pro-inflammatory bacteria, and reduce the damage of endotoxins to the liver, a protective system for the gut-liver axis is formed. This breaks through the limitations of traditional products that only focus on the single mechanism of alcohol metabolism, and reduces the chronic damage of alcohol to the gastrointestinal tract and liver from the source.

[0028] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0029] Figure 1This is a schematic flowchart illustrating the preparation method of the liver-protecting, liver-protecting, and hangover-relieving formula product of the present invention. Detailed Implementation

[0030] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0031] From the appendix Figure 1 As shown in Example 1, instant powder form

[0032] A liver-protecting and hangover-relieving formula includes: 25g of Pu-erh tea extract for regulating intestinal flora and promoting alcohol metabolism; 15g of Hovenia dulcis extract for accelerating acetaldehyde decomposition; 12g of Pueraria lobata extract for protecting liver cells and relieving gastrointestinal discomfort; 8g of corn extract for supplementing amino acids and improving post-drinking energy deficiency; 20g of fructose syrup for improving solubility and supplementing energy; 1.8g of malic acid for regulating acid-base balance and improving taste; 0.2g of vitamin B1 for participating in the synthesis of coenzymes in alcohol metabolism; 0.2g of vitamin B2 for promoting cell repair; 0.5g of compound vitamins for synergistically enhancing metabolic function; 0.3g of rice bran extract for relieving post-drinking fatigue; and an appropriate amount of purified water for regulating humidity.

[0033] The preparation method of a liver-protecting, liver-protecting, and hangover-relieving formula product specifically includes the following steps:

[0034] Pu-erh tea extract, Hovenia dulcis extract, and Pueraria lobata extract were pulverized to a particle size of 80-100 mesh using an ultrafine pulverizer and then sieved to remove impurities. Corn peptides were pulverized to 120 mesh to ensure uniform dispersion. A supercritical CO2 extraction combined with macroporous resin purification process was used to achieve a theabrownin purity of over 95%.

[0035] The above-mentioned pulverized solid raw materials, vitamin B1, B2, compound vitamins, and rice bran extract were added to a three-dimensional mixer and mixed at 300 r / min for 15 min to obtain mixed powder A.

[0036] Add fructose syrup and malic acid to 50 ml of purified water and stir in a 50°C water bath until completely dissolved to obtain solution B; slowly add solution B to mixed powder A and stir until a moist soft material is formed.

[0037] The soft material is granulated using a 10-mesh sieve and dried in a 60℃ forced-air drying oven for 2 hours until the moisture content is less than 3%. After drying, it is granulated again using a 20-mesh sieve to obtain uniform granules. The granules are then packaged into aluminum foil bags, 5g per bag, and sealed to obtain the powdered instant product.

[0038] The particles have a diameter of 20-40 mesh and are soluble in water at 25℃. 5g / 100ml dissolves completely within 3 minutes without any precipitate.

[0039] Example 2, tablet type

[0040] A liver-protecting and hangover-relieving formula product includes 30g of Pu-erh tea extract; 12g of Hovenia dulcis extract; 10g of Pueraria lobata extract; 15g of corn extract; 8g of fructose syrup; 1.8g of malic acid; 0.1g of vitamin B1; 0.1g of vitamin B2; 0.5g of multivitamins; 0.2g of rice bran extract; and 2.3g of magnesium stearate.

[0041] The preparation method of a liver-protecting, liver-protecting, and hangover-relieving formula product specifically includes the following steps:

[0042] Theabrownins, Hovenia dulcis extract, and Pueraria lobata extract were pulverized to 100 mesh, and corn peptides were pulverized to 120 mesh. These were then mixed evenly with vitamins and rice bran extract to form mixed powder C. Supercritical CO2 extraction combined with macroporous resin purification was used to achieve a theabrownin purity of over 95%.

[0043] Dissolve fructose syrup and malic acid in 20 ml of purified water to make an adhesive solution; add the solution to mixed powder C and stir until a uniform soft material is formed.

[0044] The soft material was granulated using a 16-mesh sieve, dried at 65℃ for 1.5 hours until the moisture content was less than 4%, and then granulated using a 20-mesh sieve to obtain dry granules D.

[0045] Add magnesium stearate to dry granules D, and mix for 10 minutes at 250 rpm using a three-dimensional mixer to ensure uniform dispersion of the lubricant. Compress the tablets using a rotary tablet press with a 6mm die diameter, a compression pressure of 20MPa, a single tablet weight of 1g, and a hardness controlled between 3-5kgf. Check the tablet disintegration time; in simulated gastric fluid, complete disintegration should occur in less than 15 minutes. After passing the test, package the tablets in aluminum-plastic packaging.

[0046] Example 3, Granulation type

[0047] A liver-protecting and hangover-relieving formula product includes 22g of Pu-erh tea extract; 18g of Hovenia dulcis extract; 15g of Pueraria lobata extract; 10g of corn extract; 16g of fructose syrup; 2.0g of malic acid; 0.3g of vitamin B1; 0.2g of vitamin B2; 0.7g of compound vitamins; 0.2g of rice bran extract; and 5.3g of sodium carboxymethyl cellulose.

[0048] The preparation method of a liver-protecting, liver-protecting, and hangover-relieving formula product specifically includes the following steps:

[0049] Add fructose syrup and malic acid to 200ml of purified water and stir at 50℃ until completely dissolved to obtain solution E.

[0050] Theabrownin, Hovenia dulcis extract, Pueraria lobata extract, and corn peptide were dissolved in 40℃ and 50ml of warm water, respectively. The solutions were filtered through a 0.45μm filter membrane to remove insoluble matter, yielding solution F.

[0051] Add solution F, vitamins, and rice bran extract to solution E and stir well; add the remaining purified water to a total mass of 500g, stir for 10 minutes, and adjust the pH to 3.8.

[0052] The solution was homogenized by a high-pressure homogenizer at a pressure of 20 MPa to remove air bubbles; then it was sterilized by UHT at 135°C for 3 seconds and rapidly cooled to below 40°C.

[0053] Under aseptic conditions, pour the liquid into a 500ml PET bottle, screw on the cap to seal, and affix the label.

[0054] The pH is 3.5-4.0, centrifuged at 3000 r / min for 15 min, with no stratification or precipitation; shelf life is 12 months, stored at room temperature and protected from light.

[0055] The experimental comparative examples used rats with an alcoholic liver injury model as experimental subjects. The embodiments of the present invention and three comparative examples were set up to detect the alcohol detoxification efficiency, liver function indicators and changes in intestinal flora.

[0056] Experimental materials and grouping:

[0057] Fifty male SPF-grade SD rats, weighing 220-250g, were randomly divided into 5 groups of 10 rats each.

[0058] Blank control group: normal diet, no alcohol consumption;

[0059] Model control group: alcohol consumption and saline administration via gavage;

[0060] Comparative Example 1: Pueraria lobata extract, with dosage calculated based on the equivalent content of Pueraria lobata in this invention;

[0061] Comparative Example 2: Theabrownins from Pu-erh tea extract were removed, and the remaining components were in the same proportions as in Example 1 of this invention;

[0062] One embodiment of the present invention is a powder that dissolves quickly and is administered by gavage at a daily dose of 10g / kg body weight.

[0063] Modeling and intervention methods:

[0064] Except for the blank control group, the other four groups were given 10 ml / kg body weight of 56-degree liquor by gavage daily for 7 consecutive days to establish an alcoholic liver injury model.

[0065] Comparative Examples 1 and 2, and the present invention group, served as intervention groups. The corresponding preparation was administered by gavage 30 minutes after drinking alcohol. The model control group was administered an equal volume of physiological saline by gavage, and the blank control group had a normal diet.

[0066] In Comparative Example 1, the formula was 12g of kudzu root extract, which was prepared by pulverizing the kudzu root extract to 80 mesh and then administering it directly by gavage.

[0067] In Comparative Example 2, the formula consisted of 15g of Hovenia dulcis extract, 12g of Pueraria lobata extract, 8g of corn peptide, 20g of fructose syrup, 1.8g of malic acid, 0.2g of vitamin B1, 0.2g of vitamin B2, 0.5g of compound vitamins, and 0.3g of rice bran extract. The preparation method was the same as the powdered instant preparation method in Example 1 of this invention, and the powder was suspended in physiological saline and administered by gavage.

[0068] Detection time and indicators:

[0069] Time of intoxication: The time from administration of alcohol to the disappearance of the righting reflex. Time to sober up: The time from the disappearance of the righting reflex to its recovery. Blood alcohol concentration (BAC): Blood samples were taken from the orbital rim at 1 hour, 3 hours, and 6 hours after administration, and detected by gas chromatography. Liver function indicators: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured 7 days after oral gavage.

[0070] Intestinal flora indicators: Seven days after gavage, rat feces were collected, and the ratio of Bifidobacteria (beneficial bacteria) to Escherichia coli (opportunistic pathogens) in the intestinal flora was detected by qPCR. The experimental results are shown in Table 2:

[0071]

[0072]

[0073] Table 1

[0074] Experimental conclusion: Compared with Comparative Example 1, Comparative Example 1 only contains kudzu root extract, which can shorten the sobering time, but has limited improvement on liver function indicators and intestinal flora. The ratio of Bifidobacterium / Escherichia coli is only 1.75 times that of the model group.

[0075] In Example 1 of this invention, due to the synergistic effect of theaflavins, raisins, and kudzu root, the sobering time was shortened by 47.8% compared to Comparative Example 1, ALT decreased by 55.9%, and the balance of intestinal flora was restored more significantly, proving that the compound formula is superior to the single ingredient.

[0076] Compared with Comparative Example 2, although Comparative Example 2 retained other plant extracts and nutrients after removing theaflavins, its alcohol detoxification efficiency and liver function protection were significantly weaker than those of Example 1 of the present invention.

[0077] Among them, theabrownin reduces the damage of endotoxins to the liver by regulating the intestinal flora, while Comparative Example 2, lacking theabrownin, is unable to form a protective mechanism for the intestinal-liver axis, proving that theabrownin is the core component for achieving synergistic effects.

[0078] The first embodiment of the present invention can significantly prolong the time of intoxication and shorten the time of sobering up, and the serum ALT and AST levels are close to those of the blank control group, proving that it can not only accelerate alcohol metabolism, but also fundamentally reduce the damage of alcohol to the liver, which is superior to traditional products that simply relieve intoxication without liver protection.

[0079] In summary, the combination of theaflavins with Hovenia dulcis and Pueraria lobata extracts of this invention achieves multi-target effects such as accelerating alcohol metabolism, regulating intestinal flora, and protecting hepatocytes, which is superior to formulations with single ingredients or missing core ingredients. Pu-erh tea extract, as a key component for regulating the intestinal and liver axis, has an innovative advantage over existing technologies due to its synergistic effect with other components.

[0080] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0081] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0082] The embodiments of the present invention are given for the purposes of illustration and description. Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Any changes, modifications, substitutions and variations made by those skilled in the art to the above embodiments within the scope of the present invention should be included within the protection scope of the present invention.

Claims

1. A liver-protecting, liver-protecting, and hangover-relieving formula product, characterized in that, It is made from the following raw materials in weight percentage: Pu-erh tea extract 12-25%; Hovenia dulcis extract 8-18%; Pueraria lobata extract 6-15%; Corn extract 5-10%; Fructose syrup 10-20%; Malic acid 1.5-2.0%; Vitamin B1 0.05-0.3%; Vitamin B2 0.05-0.2%; Complex vitamins 0.3-0.7%; Rice bran extract 0.03-0.08%; Sodium carboxymethyl cellulose 2.7-5.3%; Magnesium stearate 1.5-2.3%; Among them, the compound vitamins include vitamin B6, B12, and niacin; the corn extract includes corn peptides; and the Pu-erh tea extract includes theabrownins. The product is in solid or liquid form, wherein the solid form includes powder, tablet, and granulation, and the liquid form has a volume of 50-500ml.

2. The liver-protecting and hangover-relieving formula product according to claim 1, characterized in that: The mass fraction of theabrownin in Pu-erh tea extract is greater than 95%.

3. The liver-protecting and hangover-relieving formula product according to claim 1, characterized in that: The weight ratio of Hovenia dulcis extract to Pueraria lobata extract is 1:0.8-1:1.

2.

4. The liver-protecting and hangover-relieving formula product according to claim 1, characterized in that: In a multivitamin, the weight ratio of vitamin B6, B12, and niacin is 2:1:

3.

5. A method for preparing a liver-protecting, liver-protecting, and hangover-relieving formula product as described in any one of claims 1-4, characterized in that, Specifically, the following steps are included: Step 1: Pulverize the Pu-erh tea extract, Hovenia dulcis extract, and Pueraria lobata extract to a particle size of less than 50μm, and sieve them for later use. Among them, the supercritical CO2 extraction combined with macroporous resin purification process is used to make the purity of theabrownin reach more than 95%. Step 2: Weigh each raw material according to the weight percentage, add them to the mixer, and mix for 15-30 minutes at a speed of 300-500 r / min to obtain the mixture. Step 3: When preparing solid dosage forms, the mixture is granulated using either dry or wet granulation. After granulation, it is dried until the moisture content is less than 5%. The binder for wet granulation is 5-10% starch slurry. The dried granules are used to prepare powder, tablet, or granulated forms. When preparing the liquid preparation, add the mixture to 50-500ml of purified water, stir and dissolve at 50-60℃, continue stirring for 10-20min, cool, fill and sterilize.

6. The preparation method of the liver-protecting and hangover-relieving formula product according to claim 5, characterized in that: In step three, the drying temperature for wet granulation is 60-80℃, and the drying time is 2-4 hours.

7. The preparation method of the liver-protecting and hangover-relieving formula product according to claim 5, characterized in that: In step three, the sterilization conditions for liquid dosage forms are moist heat sterilization at 121℃ for 15-20 minutes.

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