Functionalized exhaled air sampling kit and plasma ionization device with same

Abstract

The invention relates to the field of medical equipment, and provides a functionalized exhaled air sampling kit and a plasma ionization device with the same. The kit comprises a gas collecting pipe, a first adsorption part, a second adsorption part, a first sealing cover and a second sealing cover. The gas collecting pipe comprises a first port and a second port, and the first port is used for being detachably connected with the gas blowing cover; in the direction from the first port to the second port, the gas collecting pipe is sequentially filled with the first adsorption part and the second adsorption part; the first sealing cover detachably covers the first port, and the second sealing cover detachably covers the second port; wherein the first adsorption part is used for adsorbing polar compounds in exhaled air, and the second adsorption part is used for adsorbing non-polar compounds in the exhaled air. According to the kit provided by the invention, long-distance transportation of expired gas and high efficiency and accuracy of detection can be ensured.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to a functionalized exhaled breath sampling kit and a plasma ionization device having the same. Background Technology

[0002] The gases exhaled by the human body contain an extremely rich array of biochemical information. The hundreds of trace volatile organic compounds detected in these gases are essentially the body's "chemical fingerprints," directly participating in and reflecting the body's immune regulation and metabolic processes. These trace chemical signals can accurately map the functional state and potential pathological changes of various systems in the human body, providing a novel non-invasive detection method for medical diagnosis.

[0003] Isoprene, a compound produced by the body's own metabolism, is considered an important disease marker molecule in medicine. Its formation is closely related to cholesterol biosynthesis, particularly through the mevalonate pathway and squalene oxidation. Studies have shown that changes in the concentration of isoprene in exhaled breath are significantly correlated with blood cholesterol levels, potentially enabling early screening for cardiovascular diseases.

[0004] Modern medicine has combined breath composition research with artificial intelligence technology to develop the emerging field of "breath molecular mapping analysis." Through advanced algorithmic models and in-depth analysis of breath data, this technology exhibits numerous advantages: no blood sampling required, simple operation, and high repeatability, making it particularly suitable for screening chronic metabolic diseases such as hyperlipidemia and diabetes. Its diagnostic accuracy is comparable to traditional blood tests, but it is lower in cost and easier to implement, providing an ideal tool for population screening in the public health field.

[0005] The concentration of volatile organic compounds in exhaled breath is extremely low, typically only one part per billion to one part per million, which places extremely high demands on detection technology. Mass spectrometry, with its rapid response, high resolution, and excellent selectivity, has become the core technology in this field. This technology has been widely applied in biomedical research, drug development, environmental monitoring, and many other fields. In breath analysis, the mass spectrometer separates and identifies gaseous ions using an electromagnetic field; its core component is the efficient ionization process of the sample.

[0006] Despite the significant advantages of mass spectrometry, current breath analysis still faces numerous challenges. Mainstream methods rely on large-scale equipment coupled with gas chromatography, which is complex and requires specialized personnel, limiting its application. A breakthrough lies in developing direct ionization techniques that simplify procedures and eliminate the need for pre-separation, which would greatly promote the widespread adoption of breath analysis in clinical settings and large-scale screening.

[0007] The method of collecting breath samples also restricts technological development. Existing methods each have their limitations: on-site breath testing is inconvenient to implement remotely, and breath bag collection is easily affected by the environment. Summary of the Invention

[0008] In order to solve the above-mentioned technical problems, or at least partially solve the above-mentioned technical problems, the present invention provides a functionalized exhaled breath sampling kit and a plasma ionization device having the same.

[0009] In a first aspect, this application provides a functionalized exhaled breath sampling kit, comprising: a gas collection tube including a first port and a second port, the first port being detachably connected to an exhalation mask; a first adsorbent and a second adsorbent, wherein the first adsorbent and the second adsorbent are sequentially filled in the gas collection tube in a direction from the first port to the second port; a first sealing cap and a second sealing cap, the first sealing cap being detachably sealed to the first port, and the second sealing cap being detachably sealed to the second port; wherein the first adsorbent is used to adsorb polar compounds in the exhaled breath, and the second adsorbent is used to adsorb non-polar compounds in the exhaled breath.

[0010] In this way, the functional exhaled breath sampling kit provided in this application allows the subject to approach the inhalation mask, with the inhalation mask close to the subject's mouth, and continuously and slowly blow air for 10 seconds.

[0011] The first adsorbent adsorbs polar compounds in exhaled air, while the second adsorbent adsorbs non-polar compounds. Specifically, polar compounds such as water vapor, aldehydes, ketones, and alcohols are efficiently adsorbed by the first adsorbent (activated alumina), while weakly polar and non-polar compounds such as isoprene are efficiently adsorbed by the second adsorbent (graphene sponge), ensuring stable storage of exhaled air. The gas collection tube is then sealed at both ends by a first and a second sealing cap, isolating the exhaled air from the outside environment and ensuring long-distance transport of the exhaled air. In other words, exhaled air can be collected at a first location and then detected by mass spectrometry at a second location, ensuring efficient and accurate long-distance transport and detection of exhaled air.

[0012] Specifically, it can be carried out through home collection and long-distance transportation.

[0013] In one possible implementation of this application, the functionalized exhaled breath sampling kit further includes: a first glass fiber element disposed within the gas collection tube and located between the first adsorbent element and the second adsorbent element.

[0014] In one possible implementation of this application, the functionalized exhaled breath sampling kit further includes: a second glass fiber element disposed within the gas collection tube and located between the first port and the first adsorption element; and a third glass fiber element disposed within the gas collection tube and located between the second port and the second adsorption element.

[0015] Secondly, this application also provides a plasma ionization device with a functionalized exhaled breath sampling kit. The plasma ionization device includes: a functionalized exhaled breath sampling kit, wherein the functionalized exhaled breath sampling kit is any of the functionalized exhaled breath sampling kits described above; an electric heating tube, wherein the electric heating tube includes a heating inlet and a heating outlet, wherein the functionalized exhaled breath sampling kit extends into the electric heating tube through the heating inlet, and the second port faces the heating outlet; and an ionization tube section, wherein one end of the ionization tube section is connected to the heating outlet, and the other end is provided with a mass spectrometer interface.

[0016] The technical effects of any design scheme in the second aspect can be seen in the technical effects of different design methods in the first aspect, and will not be repeated here.

[0017] In one possible implementation of this application, the plasma ionization device with a functionalized exhaled breath sampling kit further includes: a bent tube, the bent tube comprising a first tube segment and a second tube segment connected together, one end of the first tube segment being connected to the electric heating tube and the other end being connected to the second tube segment, the other end of the second tube segment being connected to the ionization tube segment, and the extension direction of the first tube segment intersecting the extension direction of the second tube segment.

[0018] In one possible implementation of this application, the plasma ionization device with a functional exhaled breath sampling kit further includes: a first sealing sleeve disposed between the heating inlet and the gas collection tube.

[0019] In one possible implementation of this application, the plasma ionization device with a functional exhaled breath sampling kit further includes: a temperature sensor disposed on the electric heating tube; and a temperature controller electrically connected between the electric heating tube and the temperature sensor.

[0020] In one possible implementation of this application, the ionization tube segment includes: a metal tube, a ceramic tube, and a copper ring. One end of the metal tube is connected to the second tube segment, and the other end is connected to the ceramic tube. The ceramic tube is sleeved on the outer periphery of the metal tube, and the copper ring is sleeved on the outer periphery of the ceramic tube. In the extending direction of the ceramic tube, the metal tube and the copper ring are spaced apart. The other end of the ceramic tube is provided with a mass spectrometer interface. An AC power supply is provided, which is electrically connected to both the metal tube and the copper ring, and the metal tube is grounded. Attached Figure Description

[0021] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0022] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 A schematic diagram of the functionalized exhaled breath sampling kit provided in an embodiment of the present invention;

[0024] Figure 2 The plasma ionization device with a functionalized exhaled breath sampling kit provided in the embodiments of this application;

[0025] Figure 3 The mass spectrum of exhaled air collected in the application of the plasma ionization device provided in the embodiments of this application.

[0026] Figure label:

[0027] 10. Reagent kit; 11. Gas collection tube; 12. First adsorption element; 13. Second adsorption element; 14. First sealing cap; 15. Second sealing cap; 16. First glass fiber component; 17. Second glass fiber component; 18. Third glass fiber component;

[0028] 20. Inflatable mask;

[0029] 100. Plasma ionization device;

[0030] 30. Electric heating element; 31. First sealing sleeve; 32. Temperature sensor; 33. Temperature controller; 40. Bend; 50. Metal tube; 60. Ceramic tube; 70. Copper ring; 80. Mass spectrometer interface; 90. AC power supply. Detailed Implementation

[0031] To better understand the above-mentioned objectives, features, and advantages of the present invention, the solutions of the present invention will be further described below. It should be noted that, unless otherwise specified, the embodiments of the present invention and the features thereof can be combined with each other.

[0032] Many specific details are set forth in the following description in order to provide a full understanding of the invention, but the invention may also be practiced in other ways different from those described herein; obviously, the embodiments in the specification are only some embodiments of the invention, and not all embodiments.

[0033] The gases exhaled by the human body contain an extremely rich array of biochemical information. The hundreds of trace volatile organic compounds detected in these gases are essentially the body's "chemical fingerprints," directly participating in and reflecting the body's immune regulation and metabolic processes. These trace chemical signals can accurately map the functional state and potential pathological changes of various systems in the human body, providing a novel non-invasive detection method for medical diagnosis.

[0034] Isoprene, a compound produced by the body's own metabolism, is considered an important disease marker molecule in medicine. Its formation is closely related to cholesterol biosynthesis, particularly through the mevalonate pathway and squalene oxidation. Studies have shown that changes in the concentration of isoprene in exhaled breath are significantly correlated with blood cholesterol levels, potentially enabling early screening for cardiovascular diseases.

[0035] Modern medicine has combined breath composition research with artificial intelligence technology to develop the emerging field of "breath molecular mapping analysis." Through advanced algorithmic models and in-depth analysis of breath data, this technology exhibits numerous advantages: no blood sampling required, simple operation, and high repeatability, making it particularly suitable for screening chronic metabolic diseases such as hyperlipidemia and diabetes. Its diagnostic accuracy is comparable to traditional blood tests, but it is lower in cost and easier to implement, providing an ideal tool for population screening in the public health field.

[0036] The concentration of volatile organic compounds in exhaled breath is extremely low, typically only one part per billion to one part per million, which places extremely high demands on detection technology. Mass spectrometry, with its rapid response, high resolution, and excellent selectivity, has become the core technology in this field. This technology has been widely applied in biomedical research, drug development, environmental monitoring, and many other fields. In breath analysis, the mass spectrometer separates and identifies gaseous ions using an electromagnetic field; its core component is the efficient ionization process of the sample.

[0037] Despite the significant advantages of mass spectrometry, current breath analysis still faces numerous challenges. Mainstream methods rely on large-scale equipment coupled with gas chromatography, which is complex and requires specialized personnel, limiting its application. A breakthrough lies in developing direct ionization techniques that simplify procedures and eliminate the need for pre-separation, which would greatly promote the widespread adoption of breath analysis in clinical settings and large-scale screening.

[0038] The method of collecting breath samples also restricts technological development. Existing methods each have their limitations: on-site breath testing is inconvenient to implement remotely, and breath bag collection is easily affected by the environment.

[0039] To resolve the above technical issues, please refer to Figure 1 This application provides a functionalized exhaled breath sampling kit 10, which may include a gas collection tube 11, a first adsorption element 12, a second adsorption element 13, a first sealing cap 14, and a second sealing cap 15.

[0040] The gas collecting tube 11 can be a glass capillary tube made of borosilicate material. The gas collecting tube 11 is formed into a tube with open ends. The outer diameter can be 3mm, the inner diameter can be 2.5mm, and the length can be 10cm. The two ends of the gas collecting tube 11 are a first port and a second port, respectively. The first port is used for detachable connection with the blowing cover 20.

[0041] The air blower 20 can be made of polypropylene. The polypropylene air blower 20 meets food contact safety standards, is resistant to chemical corrosion, and is inexpensive. The front end of the air blower 20 is designed as a flat arc shape that fits the lip shape to reduce the risk of air leakage. The end has a standardized interface with an inner diameter of 3mm.

[0042] The first port and the outlet of the air blowing cover 20 are sealed and detachable through a plug-in connection. Specifically, the outer diameter of the first port gradually decreases in the direction of the free end. The outer diameter of the free end of the first port is smaller than the inner diameter of the outlet of the air blowing cover 20. The outer diameter of the fixed end of the first port is larger than that of the air blowing cover 20. The first port and the air blowing cover 20 are sealed and detachable through an interference fit.

[0043] In the direction from the first port to the second port, the first adsorbent 12 and the second adsorbent 13 sequentially fill the gas collecting tube 11. Filling means that the radial dimensions of the first adsorbent 12 and the second adsorbent 13 match the inner diameter of the gas collecting tube 11, so that the gas collecting tube 11 can be filled radially.

[0044] The first adsorbent 12 is used to adsorb polar compounds in exhaled air, and the second adsorbent 13 is used to adsorb non-polar compounds in exhaled air.

[0045] The first adsorbent 12 can be made of activated alumina, which is a white, spherical, porous particle with uniform particle size, smooth surface, size of 50 to 300 mesh, and surface area of ​​155 m² / g. It has excellent thermal stability and can efficiently adsorb polar compounds such as water vapor, aldehydes, ketones, and alcohols.

[0046] The adsorption material used in the second adsorption element 13 can be graphene sponge. Graphene sponge is a three-dimensional porous structure material based on graphene, which combines the nano-properties of graphene with the macroscopic properties of sponge. It has a porosity of more than 99%, and its adsorption efficiency is far superior to that of activated carbon and ordinary sponge. It has excellent thermal stability and can selectively and efficiently adsorb weakly polar and non-polar compounds such as isoprene.

[0047] It is understandable that exhaled air can pass through the first adsorption element 12 and the second adsorption element 13.

[0048] The first sealing cap 14 is removably sealed at the first port, and the second sealing cap 15 is removably sealed at the second port.

[0049] Specifically, the first sealing cap 14 can be placed on the outside of the first port to block the first port, or it can be placed on the inside of the first port to block the first port.

[0050] Furthermore, the second sealing cap 15 can be placed on the outside of the second port to seal the second port, or it can be placed on the inside of the second port to seal the second port.

[0051] In this way, the functional exhaled breath sampling kit 10 provided in this application allows the subject to approach the inhalation mask 20, with the inhalation mask 20 close to the subject's mouth, and continuously and slowly blow air for 10 seconds.

[0052] The first adsorbent 12 adsorbs polar compounds in exhaled air, while the second adsorbent 13 adsorbs non-polar compounds. Specifically, polar compounds such as water vapor, aldehydes, ketones, and alcohols are efficiently adsorbed by the first adsorbent 12 (activated alumina), while weakly polar and non-polar compounds such as isoprene are efficiently adsorbed by the second adsorbent 13 (graphene sponge), ensuring stable storage of exhaled air. Then, the first sealing cap 14 and the second sealing cap 15 seal both ends of the gas collection tube 11, ensuring that the exhaled air in the gas collection tube 11 is isolated from the outside world and ensuring long-distance transport of exhaled air. In other words, exhaled air can be collected at a first location and then detected by mass spectrometry at a second location, ensuring efficient and accurate long-distance transport and detection of exhaled air.

[0053] Specifically, samples can be collected at home, transported over long distances, and then tested at a centralized location.

[0054] Please refer to some embodiments of this application. Figure 1 The functional exhaled breath sampling kit 10 also includes a first glass fiber component 16, which is disposed inside the gas collection tube 11 and located between the first adsorbent component 12 and the second adsorbent component 13.

[0055] The first glass fiber component 16 can be glass fiber cotton, which is a high-performance inorganic non-metallic material. Its porous fiber structure has good air permeability, allowing exhaled air to pass through. It is produced without the addition of adhesives and does not release toxic gases at high temperatures. It is used to seal activated alumina and graphene sponge in glass capillaries and isolate the two.

[0056] Therefore, by setting the first glass fiber component 16, the first adsorption component 12 and the second adsorption component 13 can be separated, avoiding the first adsorption component 12 and the second adsorption component 13 from crossing each other during use and affecting the adsorption effect.

[0057] Furthermore, the functional exhaled breath sampling kit 10 also includes a second glass fiber element 17 and a third glass fiber element 18. The second glass fiber element 17 is disposed in the gas collection tube 11 and located between the first port and the first adsorption element 12. The third glass fiber element 18 is disposed in the gas collection tube 11 and located between the second port and the second adsorption element 13.

[0058] Both the second fiberglass component 17 and the third fiberglass component 18 can be fiberglass wool.

[0059] Therefore, by setting the second glass fiber component 17, the third glass fiber component 18 and the first glass fiber component 16, the positions of the first adsorbent 12 and the second adsorbent 13 are determined, thus preventing the first adsorbent 12 and the second adsorbent 13 from sliding out of the gas collection tube 11.

[0060] Secondly, please refer to Figure 2 This application also provides a plasma ionization device 100 with a functionalized exhaled breath sampling kit, which may include a functionalized exhaled breath sampling kit 10, an electric heating tube 30, and an ionization tube segment.

[0061] The functionalized exhaled breath sampling kit 10 is any of the functionalized exhaled breath sampling kits 10 described above.

[0062] The electric heating tube 30 includes a heating inlet and a heating outlet. The functionalized exhaled breath sampling kit 10 extends into the electric heating tube 30 through the heating inlet, with the second port facing the heating outlet.

[0063] The electric heating tube 30 has a heat collection temperature of 0 to 300℃. The electric heating tube 30 is composed of a stainless steel tube shell, a nickel-chromium alloy heating wire, etc. The electric heating tube 30 is formed into a tubular structure with open ends. The nickel-chromium alloy heating wire is located in the center of the tube shell of the electric heating tube 30. It heats up quickly after being energized. In order to facilitate the insertion and removal of the gas collection tube 11, the diameter of the heating cavity inside the electric heating tube 30 is set to 3.2mm and the length is 8cm.

[0064] One end of the ionization tube section is connected to the heating outlet, and the other end is equipped with a mass spectrometer interface 80. The mass spectrometer interface 80 is used to connect to a mass spectrometer.

[0065] It should be noted that under the high temperature of the electric heating tube 30, polar and weak / non-polar compounds in the first adsorbent 12 and the second adsorbent 13 are precipitated out, ionized through the ionization tube section, and then enter the mass spectrometer for analysis.

[0066] Please refer to some embodiments of this application. Figure 2 The plasma ionization device 100 also includes a bent tube 40, which includes a first tube segment and a second tube segment connected together. One end of the first tube segment is connected to the electric heating tube 30, and the other end is connected to the second tube segment. The other end of the second tube segment is connected to the ionization tube segment. The extension direction of the first tube segment intersects the extension direction of the second tube segment.

[0067] It should be noted that the first adsorbent 12 and the second adsorbent 13 in the gas collection pipe 11 may fall out of the gas collection pipe 11. Therefore, by setting the bend 40, it is possible to prevent the first adsorbent 12 and the second adsorbent 13 from falling into the ionization tube section and affecting the normal operation of the ionization tube section.

[0068] In the specific implementation process, the first pipe section and the second pipe section are set perpendicularly, the first pipe section is set vertically, and the second pipe section is set horizontally.

[0069] The 40-inch bend can be made of stainless steel and can be 1 / 16 inch in size.

[0070] Please refer to some embodiments of this application. Figure 2 The plasma ionization device 100 also includes a first sealing sleeve 31, which is located between the heating inlet and the gas collection pipe 11.

[0071] The first sealing sleeve 31 can be made of stainless steel and is connected to the heating inlet of the electric heating tube 30. Its size can be 1 / 8 inch.

[0072] Thus, a sealed connection between the gas collection pipe 11 and the electric heating pipe 30 is achieved by setting the first sealing sleeve 31.

[0073] Furthermore, a second sealing sleeve may also be provided between the bent tube 40 and the electric heating tube 30.

[0074] Please refer to some embodiments of this application. Figure 2 The plasma ionization device 100 may also include a temperature sensor 32 and a temperature controller 33. The temperature sensor 32 is disposed on the electric heating tube 30, and the temperature controller 33 is electrically connected between the electric heating tube 30 and the temperature sensor 32.

[0075] The temperature sensor 32 can be a thermocouple. The temperature sensor 32 is used to measure the temperature of the electric heating tube 30 in real time and feed it back to the temperature controller 33. The thermocouple measurement range can be from 1 to 300℃.

[0076] Please refer to some embodiments of this application. Figure 2 The ionization tube segment may include a metal tube 50, a ceramic tube 60, a copper ring 70, and an AC power supply. One end of the metal tube 50 is connected to the second tube segment, and the other end is connected to the ceramic tube 60. The ceramic tube 60 is sleeved on the outer periphery of the metal tube 50, and the copper ring 70 is sleeved on the outer periphery of the ceramic tube 60. In the extension direction of the ceramic tube 60, the metal tube 50 and the copper ring 70 are spaced apart. The other end of the ceramic tube 60 is provided with a mass spectrometer interface 80 and an AC power supply. The AC power supply is electrically connected to the metal tube 50 and the copper ring 70 respectively, and the metal tube 50 is grounded.

[0077] The metal tube 50 can be a stainless steel tube, which is connected to the ground wire in the AC power supply wiring method. The dimensions of the metal tube 50 can be an outer diameter of 1.5mm, an inner diameter of 1.2mm, and a length of 1.5cm.

[0078] The overlap between the ceramic tube 60 and the metal tube 50 is 0.75 cm in length, and the other end is equipped with a mass spectrometer interface 80. The ceramic tube 60 can have an outer diameter of 2 mm, an inner diameter of 1.5 mm, and a length of 1.5 mm.

[0079] The metal tube 50 and the copper ring 70 can be spaced 2mm apart. In terms of power supply wiring, the copper ring 70 is connected to the high-voltage end of the high-frequency high-voltage AC power supply with a frequency of 10kHz and a voltage of 2-3kV; the dimensions of the copper ring 70 can be an outer diameter of 2.2mm, an inner diameter of 2mm, and a length of 0.5cm.

[0080] In specific use, the plasma ionization device 100 is set to a temperature of 180°C for the electric heating tube 30. The first sealing cap 14 and the second sealing cap 15 at both ends of the sample gas collection tube 11 are removed. Using the plasma ionization device of this application, the sample gas collection tube 11 is vertically inserted into the electric heating tube 30 from the heating inlet end. Under the action of high temperature, the polar and weak / non-polar compounds adsorbed in the activated alumina and graphene sponge are desorbed and ionized under the negative pressure attraction of the mass spectrometer, passing through the ionization tube section and entering the mass spectrometer for analysis.

[0081] It should be noted that the mass spectrometry analysis parameters are: positive ion mode, single-stage full scan, scan mass range 100–400 m / z, mass resolution 70,000, and maximum ion capacity 1.0 × 10⁻⁶. 6 The maximum ion implantation time was 100 ms. The resulting mass spectrum is shown below. Figure 3 As shown.

[0082] from Figure 3 The mass spectrum shows that the breath sample contains compounds such as isoprene, dihydropyrrole, ethyl acetate, 1-methyl-2-pyrrolidone, 1,6-octadiene, and hexanetriol.

[0083] The study investigates the mass spectra of volatile organic compounds exhaled by healthy individuals and individuals with hyperlipidemia to identify statistically significant differential compounds. These differential compounds are then identified, including but not limited to isoprene, acetone, and hexanetriol.

[0084] By using pattern recognition algorithms to establish statistical models for differentially expressed compounds, and constructing quantitative relationships between blood lipid levels and differentially expressed compounds such as isoprene in exhaled breath, we can achieve rapid diagnosis of hyperlipidemia and quantitative detection of blood lipid and cholesterol levels through exhaled gas chromatography-mass spectrometry.

[0085] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0086] The above description is merely a specific embodiment of the present invention, enabling those skilled in the art to understand or implement the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments described herein, but is to be accorded the widest scope consistent with the principles and novel features of the invention herein.

Claims

1. A functionalized exhaled breath sampling kit, characterized in that, include: A gas collection tube, the gas collection tube including a first port and a second port, the first port being detachably connected to a blowing hood; The first adsorbent and the second adsorbent are sequentially filled in the gas collection tube in the direction from the first port to the second port. A first sealing cap and a second sealing cap, wherein the first sealing cap is removably sealed to the first port and the second sealing cap is removably sealed to the second port; The first adsorbent is used to adsorb polar compounds in exhaled air, and the second adsorbent is used to adsorb non-polar compounds in exhaled air.

2. The functionalized exhaled breath sampling kit according to claim 1, characterized in that, Also includes: A first glass fiber element is disposed inside the gas collection tube and located between the first adsorbent and the second adsorbent.

3. The functionalized exhaled breath sampling kit according to claim 1, characterized in that, Also includes: The second glass fiber element is disposed inside the gas collection tube and located between the first port and the first adsorption element; The third glass fiber element is disposed inside the gas collection tube and located between the second port and the second adsorption element.

4. A plasma ionization device with a functionalized exhaled breath sampling kit, characterized in that, include: A functionalized exhaled breath sampling kit, wherein the functionalized exhaled breath sampling kit is any one of claims 1-3; An electric heating tube, the electric heating tube including a heating inlet and a heating outlet, wherein the functionalized exhaled breath sampling kit extends into the electric heating tube through the heating inlet, and the second port faces the heating outlet; An ionization tube section, one end of which is connected to the heating outlet, and the other end of which is provided with a mass spectrometer interface.

5. The plasma ionization device with a functionalized exhaled breath sampling kit according to claim 4, characterized in that, Also includes: The bend includes a first pipe segment and a second pipe segment connected together. One end of the first pipe segment is connected to the electric heating tube, and the other end is connected to the second pipe segment. The other end of the second pipe segment is connected to the ionization tube segment. The extension direction of the first pipe segment intersects the extension direction of the second pipe segment.

6. The plasma ionization device with a functionalized exhaled breath sampling kit according to claim 4, characterized in that, Also includes: A first sealing sleeve is disposed between the heating inlet and the gas collecting pipe.

7. The plasma ionization device with a functionalized exhaled breath sampling kit according to claim 4, characterized in that, Also includes: A temperature sensor, wherein the temperature sensor is disposed on the electric heating tube; A thermostat, which is electrically connected between the electric heating element and the temperature sensor.

8. The plasma ionization device with a functionalized exhaled breath sampling kit according to claim 5, characterized in that, The ionization tube segment includes: The device comprises a metal tube, a ceramic tube, and a copper ring. One end of the metal tube is connected to the second tube segment, and the other end is connected to the ceramic tube. The ceramic tube is sleeved on the outer periphery of the metal tube, and the copper ring is sleeved on the outer periphery of the ceramic tube. In the extension direction of the ceramic tube, the metal tube and the copper ring are spaced apart. The other end of the ceramic tube is provided with a mass spectrometer interface. An AC power supply is provided, which is electrically connected to both the metal tube and the copper ring, and the metal tube is grounded.

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