Medicinal and edible homologous compound composition with three-way effect and preparation method of medicinal and edible homologous compound composition

Abstract

The invention discloses a medicinal and edible compound composition with a three-way effect and a preparation method of the medicinal and edible compound composition, belongs to the field of functional foods, and aims to solve the problems that raw materials of an existing product do not have standards, the process is rough, adaptive crowds are narrow, and the effect is difficult to perceive. The preparation method comprises the following seven steps: raw material pretreatment, onion supercritical COextraction, segmented temperature-controlled baking, superfine grinding, gradient mixing, microwave sterilization and nitrogen packaging, a special raw material treatment method of wax gourd, perilla leaf and the like is additionally adopted, the Chinese date and ginseng health-care tea is suitable for people with congealing cold qi stagnation and blood stasis constitution and benign nodules, people with hypotension / anemia can adjust the dosage of Chinese dates and ginseng, toxin expelling and body feeling can be achieved 20-60 minutes after the Chinese date and ginseng health-care tea is taken, and the health-care tea is suitable for people with qi stagnation and blood stasis constitution and benign nodules. The microcirculation improvement rate is greater than or equal to 85% after 3 months, the shelf life of the product is greater than or equal to 18 months, and controllable components, sensitive effects and wide adaptation to people are realized.

Description

Technical Field

[0001] This invention relates to a medicinal and edible compound composition with three-way effects (clearing yang, clearing collaterals, and clearing the bowels) and its preparation method. The invention belongs to the field of functional food technology, specifically to the technical field of medicinal and edible compound compositions with three-way effects (clearing yang, clearing collaterals, and clearing the bowels) and their preparation method. Background Technology

[0002] With the increasing number of people in a sub-healthy state, microcirculation disorders, vascular congestion, and local nodules are gradually becoming common health problems, but existing conditioning products have obvious technical defects: Lack of standards for raw material quality: Most products do not specify the type, origin, and content of active ingredients of raw materials (e.g., ginseng is only labeled "ginseng" without specifying the age or saponin content), resulting in large differences in effects between batches and making it impossible to guarantee the stability of conditioning; The raw materials were poorly processed: the winter melon was often directly crushed, which made it easy to absorb moisture and clump together; the perilla leaves were not blanched, resulting in a loss of more than 50% of the volatile oil; the lotus leaves were not harvested at a standardized time, and the alkaloid content of the lotus leaves was less than 0.1%, which seriously affected the efficacy. Inaccurate preparation process: lacking key steps such as segmented baking and gradient mixing, resulting in a loss rate of over 40% of heat-sensitive components (such as ginsenosides and sea buckthorn vitamin C), and low bioavailability; the packaging does not use inert gas protection, resulting in a short product shelf life (mostly ≤6 months). Limited application scenarios: No suitable solutions have been designed for people with low blood pressure, anemia, or nodules, and there are no clear criteria for judging the effectiveness (such as no detoxification sensation or corresponding test indicators), so users cannot confirm the effectiveness of the treatment. Insufficient safety and stability: Some products may have excessive total bacterial count (>3000 CFU / g) or high risk of heavy metal residue due to process defects, making them unsuitable for long-term use. To address the aforementioned issues, this invention provides a three-pronged conditioning compound composition that is "controllable in composition, replicable in process, perceptible in effect, and adaptable to various population groups" by clarifying raw material standards, innovating raw material processing methods, optimizing preparation processes, and expanding applicable applications. Summary of the Invention

[0003] The technical problem to be solved by this invention is to overcome the existing defects and provide a medicinal and edible compound composition with three-way effects and its preparation method. Through precise raw material ratio, differentiated raw material processing and step-by-step preparation process, it achieves the triple conditioning effects of "unblocking yang, unblocking collaterals, and unblocking the bowels". It can be used to improve microcirculation disorders, vascular blockage and toxin accumulation caused by cold stagnation and blood stasis constitution. It can also help improve local blockage problems such as breast nodules and thyroid nodules. At the same time, it is suitable for special groups such as low blood pressure and anemia. It belongs to the category of functional medicinal and edible products that can be industrially produced.

[0004] To achieve the above objectives, the present invention provides the following technical solution: A medicinal and edible compound composition with three-way effects is composed of the following raw materials in parts by weight: 8-15 parts of kudzu root, 5-10 parts of ginseng, 6-12 parts of winter melon, 3-8 parts of perilla leaf, 5-10 parts of sea buckthorn fruit, 4-8 parts of lotus leaf, 6-12 parts of jujube, 3-6 parts of cinnamon, 2-5 parts of onion extract, 8-15 parts of hawthorn, and 4-8 parts of dried ginger; wherein the onion extract contains ≥1.2% sulfide and the ginseng contains ≥3.0% ginsenoside Rg1.

[0005] As a preferred embodiment of the present invention, the method for preparing the compound composition includes the following steps: (1) Raw material pretreatment: Winter melon is freeze-dried under vacuum, perilla leaves are blanched and then dried at low temperature, and lotus leaves are blanched, then dried at low temperature and crushed into coarse powder. (2) Extraction of active ingredients: The active ingredients of onions are extracted using supercritical CO2 extraction technology; (3) Low-temperature baking: The pre-treated kudzu root, ginseng, jujube, cinnamon, dried ginger and hawthorn are baked separately, and the moisture content of the raw materials after baking is controlled to be ≤6%; (4) Ultrafine grinding: Grind the baked raw materials to a particle size ≤45μm; (5) Gradient mixing: First mix the fat-soluble components, then add the water-soluble components, and the mixing uniformity is ≥98%; (6) Microwave sterilization: Microwave sterilization is used to ensure that the total number of colonies is ≤1000 CFU / g; (7) Packaging: Inert gas is used for packaging, and each bag contains 10g.

[0006] As a preferred embodiment of the present invention, the raw materials in the compound composition are: Winter melon: Fresh winter melon is peeled and seeded, then cut into 2cm cubes. It is then processed using vacuum freeze-drying technology at a temperature of -40℃ and a vacuum degree of 10Pa. The moisture content after freeze-drying is ≤5%. Perilla leaves: Select tender perilla leaves harvested in the current year, blanch them at 120℃ for 30 seconds, and then dry them at a low temperature of 40-45℃. After drying, the moisture content is ≤8% and the volatile oil content is ≥0.4%. Lotus leaves: Fresh lotus leaves harvested in July and August are selected. After blanching, they are dried at a low temperature of 50℃ and crushed into coarse powder with a particle size of 1-2mm. The alkaloid content of lotus leaves is ≥0.2%.

[0007] As a preferred technical solution of the present invention, it is used to improve microcirculation disorders and vascular blockage caused by cold stagnation and blood stasis constitution, and to remove heavy metals and low-density lipoprotein in the blood; it can also be used to help improve local blockage caused by breast nodules and thyroid nodules, and a differentiated detoxification sensation can appear within 20-60 minutes after taking it.

[0008] As a preferred embodiment of the present invention, the ginseng is selected from five-year-old forest-grown ginseng; the hawthorn is selected from Shandong Dajinxing hawthorn with a total flavonoid content ≥5.0%; the cinnamon is selected from Guangxi cinnamon with a cinnamaldehyde content ≥1.5%; the dried ginger is selected from Sichuan Qianwei dried ginger with a gingerol content ≥1.8%; and the jujube is selected from Xinjiang grey jujube with a sugar content ≥60%.

[0009] As a preferred technical solution of the present invention, in step (3), the low-temperature baking adopts segmented temperature control: kudzu root and ginseng are baked at 55℃ for 2-3 hours, cinnamon and dried ginger are baked at 65℃ for 2 hours, and jujube and hawthorn are baked at 60℃ for 2.5 hours; in step (4), nitrogen is introduced during ultrafine grinding to prevent oxidation, and the particle size of ginseng and cinnamon after grinding is controlled at 35-40μm, and the particle size of kudzu root and hawthorn after grinding is controlled at 40-45μm.

[0010] As a preferred technical solution of the present invention, the processing method of the sea buckthorn fruit is as follows: select fresh sea buckthorn fruit with a maturity of ≥90% to extract juice, and use spray drying technology to make powder. The spray drying inlet air temperature is 180℃ and the outlet air temperature is 80℃, and the vitamin C content after powdering is ≥200mg / 100g.

[0011] As a preferred technical solution of the present invention, when used by people with anemia, the amount of jujube in the compound composition of claim 1 is adjusted to 12-15 parts and the amount of ginseng is adjusted to 8-12 parts, and taken together with a jujube and wolfberry blood-tonifying agent, the incidence of dizziness can be reduced to less than 5%.

[0012] As a preferred technical solution of the present invention, the differentiated detoxification sensation includes: sweat gland detoxification with itchy and red skin, urine detoxification with a fishy smell and oily surface, or detoxification with smelly and loose stools; and after taking it, a heat sensation reaction will occur spreading from the head to the limbs, lasting for 20-30 minutes.

[0013] As a preferred technical solution of the present invention, the specific parameters of gradient mixing in step (5) are as follows: first, put cinnamon powder, onion extract and dried ginger powder into a three-dimensional mixer and mix at 30 r / min for 10 minutes; then add kudzu root powder, ginseng powder, jujube powder, hawthorn powder, sea buckthorn fruit powder and lotus leaf powder, adjust the speed to 40 r / min and continue mixing for 15 minutes; in step (7), the inert gas is nitrogen with a purity of ≥99.9%, and the shelf life of the product after packaging is ≥18 months, and the content of puerarin and ginsenoside Rg1 decreases by ≤5% during the shelf life.

[0014] Compared with the prior art, the beneficial effects of the present invention are: I. Raw Material Level: Excellent in Both Ingredient Controllability and Synergistic Efficacy Standardized raw material quality ensures stable efficacy: The varieties, origins, and effective ingredient contents of each key raw material are clearly defined (e.g., five-year-old forest ginseng from Changbai Mountain must meet the requirements of ginsenoside Rg1 ≥ 3.0%, cinnamaldehyde from Guangxi cinnamon ≥ 1.5%, and total flavonoids from Shandong Dajinxing hawthorn ≥ 5.0%). This avoids the defect of "large batch differences due to vague raw materials" in traditional products, ensuring that the difference in conditioning effect between different batches of products is ≤ 5%, and ensuring that users get a stable conditioning experience.

[0015] The "Three-Pronged Approach" enhances synergistic effects, achieving multi-target conditioning: Through the ingredient combination logic of "promoting Yang (cinnamon, dried ginger) - promoting blood circulation (kudzu root, hawthorn) - promoting bowel movement (winter melon, lotus leaf)," combined with the vascular softening effect of onion extract (sulfide ≥1.2%) and the anti-inflammatory protective effect of sea buckthorn fruit (vitamin C ≥200mg / 100g), a synergistic system of "warming Yang and dispelling cold - promoting blood circulation and promoting blood circulation - detoxifying and clearing stagnation - vascular maintenance" is formed. This solves the limitation of traditional single-ingredient or simple compound formulas that "can only act on a single target," and can simultaneously improve the three core problems of microcirculation disorders, vascular blockage, and accumulation of toxins in the body.

[0016] II. Raw material processing: Significantly improved retention rate of active ingredients and stability of raw materials. Targeted processing techniques reduce the loss of active ingredients: Customized processing solutions are designed for the characteristics of different raw materials—winter melon is freeze-dried at -40℃ (dietary fiber retention ≥90%) to avoid high-temperature damage to water-soluble fiber; perilla leaves are briefly blanched at 120℃ followed by low-temperature drying at 40-45℃ (volatile oil retention ≥80%) to prevent polyphenol oxidase browning and volatile oil loss; lotus leaves are blanched and dried after harvesting in July-August (lotus leaf alkaloid retention ≥95%) to ensure that key active ingredients are not degraded. Compared to traditional "direct pulverization" or "high-temperature drying," the overall retention rate of effective ingredients after raw material processing in this invention is increased by more than 60%.

[0017] Optimization of raw material physical properties lays the foundation for subsequent processes: freeze-dried winter melon forms a porous structure, making it easier to control the particle size (≤45μm) during ultrafine grinding, and increasing the dissolution rate of effective ingredients by 2 times; perilla leaves and lotus leaves undergo coarse grinding pretreatment to avoid "agglomeration and clumping" during ultrafine grinding, achieving a mixing uniformity of ≥98%, ensuring the consistency of ingredients in each bag of product, and solving the problem of "local component excess or deficiency" in traditional processes.

[0018] III. Preparation Process: A Dual Breakthrough in Bioavailability and Product Stability A refined preparation process enhances bioavailability: segmented temperature-controlled baking (55℃ for kudzu root and ginseng to prevent saponin decomposition, and 65℃ for cinnamon and dried ginger to remove excess moisture) reduces the loss of heat-sensitive components (ginsenoside Rg1 retention rate ≥90%); ultra-fine pulverization to a particle size of 35-45μm (ginseng and cinnamon even finer at 35-40μm) increases the specific surface area of ​​raw materials by more than 3 times, resulting in a dissolution rate of water-soluble components such as puerarin and lotus leaf alkaloids ≥90%; gradient mixing (first fat-soluble, then water-soluble) ensures uniform dispersion of components, avoiding "local aggregation of fat-soluble components leading to uneven absorption." The final product has 2.5 times higher bioavailability than the traditional decoction method, and a sensation of saliva production and a feeling of warmth throughout the body can be observed 20-30 minutes after consumption, proving that the active ingredients are rapidly absorbed by the body.

[0019] The combination of inert gas encapsulation and low-temperature sterilization extends shelf life and ensures safety: Nitrogen gas with a purity of ≥99.9% (oxygen residue ≤1%) is used for encapsulation, combined with 800W microwave low-temperature sterilization (powder temperature ≤60℃, total bacterial count ≤1000CFU / g). This avoids the damage to active ingredients caused by traditional moist heat sterilization (121℃) (such as a 30% increase in the retention rate of sea buckthorn vitamin C), and also prevents oxidation and deterioration after encapsulation, extending the product shelf life to ≥18 months (the shelf life of traditional products without nitrogen encapsulation is mostly ≤6 months). Furthermore, the content of puerarin and ginsenoside Rg1 decreases by ≤5% during the shelf life, ensuring stable efficacy throughout the product's entire lifecycle.

[0020] IV. Efficacy: The conditioning effects are quantifiable and perceptible, and it is suitable for a wider range of people. Significant and measurable improvements in microcirculation and blood parameters: Clinical trials involving 150 subjects showed that after 3 months of use, laser Doppler ultrasound revealed a microcirculation improvement rate of ≥85% (extremity blood flow velocity increased from <10mm / s to ≥15mm / s), a blood viscosity (high shear) improvement rate of ≥89.2% (from >5.5mPa・s to ≤5.0mPa・s), a 55% decrease in hs-CRP (inflammatory marker), a 76.5% stabilization rate in carotid artery plaques, a 35% decrease in heavy metal (lead, mercury) content in the blood, and a 28% decrease in low-density lipoprotein cholesterol. All these indicators were superior to traditional blood-activating herbal decoctions (improvement rate increased by 30%-45%).

[0021] The detoxification effect is perceptible, and users can easily judge the effectiveness of the treatment: Different detoxification sensations can appear within 20-60 minutes after taking the product (35% of people experience sweat gland detoxification: itchy and red skin; 40% of people experience urine detoxification: urine has a fishy and oily smell; 25% of people experience stool detoxification: foul-smelling and loose stool), and the heat sensation (spreading from the head to the limbs) lasts for 20-30 minutes, solving the pain point of traditional products where "the effect is not visible and users cannot confirm whether it is effective", thus enhancing users' confidence in using the product.

[0022] It helps improve local blockages and expands the treatment scenarios: For people with breast nodules and thyroid nodules (benign, diameter <2cm), after taking it for 6 months, 73.3% of the subjects had enhanced blood flow signals at the nodule site, 12% of small nodules (diameter <1cm) shrank in size, and local swelling and tenderness symptoms were relieved, filling the gap in the existing functional foods that "lack the ability to help improve local blockages".

[0023] Strong compatibility with special populations, expanding the scope of application: For people with low blood pressure (systolic blood pressure <90mmHg) and anemia (hemoglobin <120g / L), by adjusting the dosage of jujube (12-15 parts) and ginseng (8-12 parts) and combining it with jujube and wolfberry blood tonic, the incidence of dizziness has been reduced from 35% in traditional products to below 5%, and hemoglobin has been increased by an average of 10g / L. This solves the limitation of traditional products that "have no special population compatibility design and are prohibited for people with low blood pressure and anemia". The applicable population covers people with cold stagnation and blood stasis constitution, people with nodules, and people with special qi and blood deficiency, thus broadening the application scenarios of the product.

[0024] V. Safety and Practicality: Safe with no side effects, balancing industrial application and daily use. High safety with no risk of adverse reactions: According to testing by a third-party CMA institution, the product's acute toxicity test LD50 is >10g / kg (belonging to the practically non-toxic level), and the content of heavy metals (lead, mercury, arsenic) complies with GB 2762 standards. During the 3-month period of use by 150 subjects, there were no adverse reactions such as gastrointestinal irritation or allergies, and the liver and kidney function indicators (alanine aminotransferase, serum creatinine) were normal, meeting the safety requirements for "long-term conditioning".

[0025] Balancing industrial feasibility with ease of daily use: All preparation processes (freeze-drying, supercritical extraction, segmented baking, ultrafine pulverization, and nitrogen encapsulation) utilize mature industrial equipment (such as the LGJ-100F freeze dryer and the HA221-50-06 supercritical extractor), achieving a daily production capacity of 100,000 bags, suitable for large-scale production; the product is individually packaged in 10g bags, requiring only 80℃ warm water for dissolving, solving the problems of "cumbersome decoction and inconvenient carrying" in traditional Chinese medicine, and adapting to the fast-paced lifestyle of modern people.

[0026] In summary, this invention not only overcomes many of the shortcomings of traditional functional foods in terms of technology, but also achieves a comprehensive upgrade in terms of "effect stability, safety, user experience, and scope of application". It is not only feasible for industrialization, but also provides a "precise, perceptible, safe and long-lasting" three-way conditioning solution for people with different constitutions, and has significant technical value and market application prospects. Detailed Implementation

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] This invention provides a technical solution: Raw material composition of the compound composition: 1. Raw material ratio and selection criteria The compound composition of this invention, by weight, comprises: 8-15 parts kudzu root, 5-10 parts ginseng, 6-12 parts winter melon, 3-8 parts perilla leaf, 5-10 parts sea buckthorn fruit, 4-8 parts lotus leaf, 6-12 parts jujube, 3-6 parts cinnamon, 2-5 parts onion extract, 8-15 parts hawthorn, and 4-8 parts dried ginger. The selection of each ingredient and their synergistic effects are as follows: Kudzu root: Wild kudzu root from Yichang, Hubei Province is selected, containing ≥4.0% puerarin (detected by high performance liquid chromatography). It is cool in nature and sweet in taste, and can promote blood circulation, dilate blood vessels, and improve microcirculation. Ginseng: Five-year-old forest ginseng (not cultivated ginseng) from Changbai Mountain is selected. The ginsenoside Rg1 content is ≥3.0% and ginsenoside Re+Rg1 is ≥5.0% as detected by high performance liquid chromatography. It can replenish qi and promote body fluid production, enhance the body's metabolic capacity, and avoid the problem of "qi deficiency" during blood circulation. Winter melon: Selected from fresh winter melons from Shouguang, Shandong, with a water content of ≤95%. After freeze-drying, it retains ≥90% of dietary fiber, which can promote bowel movement and detoxification, and facilitate the excretion of intestinal toxins. Perilla leaves: Selected tender perilla leaves harvested in Xinghua, Jiangsu Province in the current year (harvesting time is June-July). Detected by gas chromatography, the volatile oil content is ≥0.4% (the main component is perilla aldehyde). It can regulate qi and dispel cold, and assist in promoting yang. Sea buckthorn fruit: Selected fresh sea buckthorn fruit with a maturity of ≥90% (sugar content ≥15 Brix) from Altay, Xinjiang. Detected by ultraviolet spectrophotometry, the vitamin C content is ≥200mg / 100g, and the total flavonoid content is ≥3.0%. It has anti-inflammatory and antioxidant properties and can protect the vascular endothelium. Lotus leaf: Fresh lotus leaves harvested in Anqing, Anhui Province in July and August (when the lotus leaf alkaloid content is highest) are selected. The lotus leaf alkaloid content is ≥0.2% as detected by high performance liquid chromatography. It can clear heat and promote diuresis, and help to detoxify the body. Jujubes: Selected Xinjiang grey jujubes (sweetness ≥60 Brix, measured with a handheld refractometer), which can replenish qi and balance the warming properties of cinnamon and dried ginger, preventing internal heat; Cinnamon: Selected cinnamon from Wuzhou, Guangxi (cinnamaldehyde content ≥1.5%, detected by gas chromatography), which can warm the yang and dispel cold, promote the circulation of yang qi, and unblock the meridians throughout the body; Dried ginger: Selected Sichuan Jianwei dried ginger (gingerol content ≥1.8%, detected by high performance liquid chromatography), which can warm the middle and dispel cold, and enhance the yang-invigorating effect in synergy with cinnamon; Onion extract: Prepared using supercritical CO2 extraction technology, and detected by ultraviolet spectrophotometry, the content of sulfides (such as allicin analogues) is ≥1.2%, which can soften blood vessels and reduce blood viscosity; Hawthorn: Selected from Shandong Qingzhou Dajinxing hawthorn (total flavonoid content ≥5.0%, detected by high performance liquid chromatography), which can promote blood circulation, remove blood stasis, promote lipid metabolism, and clear vascular waste. 2. Key technical features and detection methods Effective ingredient content control: The sulfide content of onion extract is ≥1.2%. The detection method is as follows: take 0.1g of onion extract, add 10mL of ethanol, and ultrasonically extract for 30 minutes. After filtration, the absorbance is measured at a wavelength of 240nm by ultraviolet spectrophotometry. The reference standard is sulfide standard (Sigma-Aldrich). The content of ginsenoside Rg1 is ≥3.0%. The detection method is as follows: high performance liquid chromatography under the "Ginseng" section of the 2020 edition of the Chinese Pharmacopoeia. The chromatographic column is a C18 column (250mm×4.6mm, 5μm), the mobile phase is acetonitrile-water (20:80), and the detection wavelength is 203nm. Differentiated detoxification sensations: Sensations that appear within 20-60 minutes after consumption are "effective conditioning signals," specifically including: Sweat gland detoxification: Itchy and red skin (local or whole body) accompanied by slight sweating, as the sweat glands expel toxins (such as heavy metals and metabolic waste) from the skin surface. This often occurs in people with more obvious blockages on the skin surface. Urine detoxification: Urine is pale yellow to dark yellow, with a slightly fishy odor, and may have small oily droplets floating on the surface (excess lipids being excreted). This is more common in people with high blood lipids. Stool detoxification: Loose stool (not diarrhea) with a foul odor indicates that the intestines are expelling accumulated waste and toxins, which often occurs in people with slower intestinal peristalsis; Thermal sensation response: Within 20-30 minutes after taking the medicine, a warm sensation spreads from the head to the trunk and limbs. This is due to the warming effect of cinnamon and dried ginger, which promotes the circulation of qi and blood. There is no burning sensation (if there is a burning sensation, it means that the dosage is not appropriate and needs to be adjusted). The duration of the reaction is positively correlated with the degree of microcirculation (the worse the microcirculation, the longer the duration, generally not exceeding 30 minutes).

[0029] Preparation method of compound composition The preparation method of this invention consists of 7 steps. The process parameters, operational objectives, and control standards for each step are as follows, ensuring that the retention rate of effective components is ≥90% and the product stability is ≥18 months: Step 1: Raw material pretreatment Winter melon processing: After peeling and deseeding fresh winter melon, cut it into 2cm square pieces (if the pieces are too large, the freeze-drying time will be long; if they are too small, they will be easily broken). Put them into a vacuum freeze dryer (model: LGJ-100F, Shanghai Dongfulong), set the freeze-drying temperature to -40℃, the vacuum degree to 10Pa, and the freeze-drying time to 12 hours. The final moisture content should be ≤5% (measured by a Karl Fischer moisture analyzer). The purpose is to retain the dietary fiber in the winter melon (avoiding high temperature damage), and the freeze-dried winter melon has a porous structure, making it easy to crush and extract the effective ingredients. Perilla leaf processing: Put tender perilla leaves into a blanching machine (model: 6CST-40, Zhejiang Lvfeng), set the temperature to 120℃ and the time to 30 seconds (if the blanching temperature is too low, the enzyme will not be deactivated and the leaves will easily turn brown; if it is too high, the volatile oil will be lost). After blanching, immediately put them into a low-temperature dryer (model: CT-C, Jiangsu Yutong), set the temperature to 40-45℃ and the wind speed to 1.5m / s, and dry them until the moisture content is ≤8% (detected by a rapid moisture analyzer). The purpose is to inactivate the polyphenol oxidase in perilla leaves to prevent browning, while retaining the volatile oil. Lotus leaf processing: After washing the fresh lotus leaves, put them into a blanching machine (temperature 110℃, time 20 seconds). After blanching, place them in a low-temperature dryer (temperature 50℃, wind speed 1.2m / s) to dry until the moisture content is ≤8%. Then use a universal pulverizer (model: WF-100, Shanghai Wangquan) to pulverize them into coarse powder with a particle size of 1-2mm (if the particle size is too large, the subsequent ultrafine pulverization efficiency will be low, and if it is too small, it will easily clump). The purpose is to break the fiber structure of the lotus leaves and promote the dissolution of lotus leaf alkali. Other raw material pretreatment: After washing kudzu root and hawthorn, cut them into thin slices 2-3mm thick (to facilitate baking and drying), and place them in a ventilated place to air dry until the moisture content is ≤12%; after removing the fibrous roots of ginseng, cut them into thin slices 1-1.5mm thick (to avoid loss of effective ingredients), and store them away from light (to prevent oxidation of ginsenosides); after removing the pits from jujubes, cut them in half (to facilitate moisture evaporation during baking); after removing impurities from cinnamon and dried ginger, grind them into 0.5-1mm coarse powder using a universal grinder (to facilitate subsequent ultrafine grinding). Step 2: Extraction of active ingredients (preparation of onion extract) Fresh onions (from Anqiu, Shandong, with a moisture content ≤90%) were peeled and chopped, then placed into a supercritical CO2 extractor (model: HA221-50-06, Jiangsu Huaan). The extraction pressure was set to 30 MPa, the temperature to 40℃, the CO2 flow rate to 20 L / h, and the extraction time to 2 hours. The separation pressure was set to 8 MPa and the separation temperature to 50℃. The collected extract was the onion extract, and the sulfide content was tested to be ≥1.2%. The reason for choosing supercritical CO2 extraction is to avoid organic solvent residue (such as the risk of solvent residue from ethanol extraction), and low-temperature extraction (40℃) can preserve the activity of sulfides (sulfides are easily decomposed at high temperatures), and the extraction rate is 60% higher than that of traditional solvent extraction. Step 3: Low-temperature baking Segmented temperature control baking is adopted (different raw materials have different heat sensitivity and require differentiated control), and the baking equipment is a segmented hot air baking machine (model: HB-800, Guangdong Haobang): Kudzu root and ginseng: Baking temperature 55℃, time 2.5 hours (ginsenoside Rg1 is easily decomposed above 60℃, so the temperature is controlled at 55℃), moisture content after baking ≤5.5%; Cinnamon and dried ginger: Baking temperature 65℃, time 2 hours (both are heat-resistant ingredients; 65℃ can remove excess moisture without affecting the content of cinnamaldehyde and gingerol), moisture content after baking ≤5%; Jujubes and hawthorns: Baking temperature 60℃, time 2.5 hours (jujubes have a high sugar content and are easily burnt if the temperature is too high; hawthorns contain organic acids and are easily volatilized if the temperature is too high), moisture content after baking ≤5.5%; During the baking process, the ingredients are turned over every 30 minutes to ensure even heating and avoid local burning. After baking, the moisture content is tested using a rapid moisture analyzer (model: XY-105W, Shanghai Xiongyu). If the moisture content is not up to standard, it is baked again (10 minutes each time, until the standard is met). Step 4: Ultrafine grinding Roasted kudzu root, ginseng, jujube, cinnamon, dried ginger, hawthorn, and dried perilla leaves and lotus leaves are coarsely ground into a vibrating ultrafine pulverizer (model: ZM-100, Beijing Greedman). Nitrogen gas (purity ≥99.9%) is introduced during pulverization at a flow rate of 5L / min to prevent oxidation of the raw materials. Particle size control: Ginseng and cinnamon are ground to 35-40μm (the effective components of the two (ginsenosides and cinnamaldehyde) need to be ground to dissolve quickly), kudzu root and hawthorn are ground to 40-45μm, and perilla leaves, lotus leaves, jujubes and dried ginger are ground to 40μm. Particle size detection method: A laser particle size analyzer (model: MS2000, Malvern, UK) was used for detection. 0.1g of the pulverized powder was taken, 10mL of ethanol was added, and the powder was ultrasonically dispersed for 2 minutes. The particle size distribution was measured to ensure that D90≤45μm (i.e., 90% of the powder particles are ≤45μm). The purpose is to increase the specific surface area of ​​the raw material and improve the dissolution rate of the effective ingredients (2 times higher than ordinary pulverization). Step 5: Gradient Blending The mixing equipment is a three-dimensional mixer (model: SYH-100, Jiangsu Saideli), which performs mixing in two steps: Step 1: Add fat-soluble ingredients (cinnamon powder, onion extract, dried ginger powder), set the speed to 30 rpm, and mix for 10 minutes (fat-soluble ingredients are prone to clumping, so mixing at a low speed first can prevent "clumps" from forming when mixing with water-soluble ingredients later). Step 2: Add water-soluble ingredients (kudzu root powder, ginseng powder, jujube powder, hawthorn powder, sea buckthorn fruit powder, lotus leaf powder), adjust the speed to 40 r / min, and continue mixing for 15 minutes; Mixing uniformity test: Refer to the "Mixing Uniformity Test Method" of Part IV of the 2020 edition of the Chinese Pharmacopoeia. Take 10 samples from different parts of the mixed powder, 0.1g of each sample, and test the puerarin content (high performance liquid chromatography). Calculate the relative standard deviation (RSD) ≤2%, that is, the mixing uniformity ≥98%, to ensure that the composition of each bag of product is consistent. Step 6: Microwave sterilization The mixed powder was put into the microwave sterilization tunnel (model: WB-100, Shanghai Wobo), and the power was set to 800W, the conveyor belt speed to 0.5m / min (corresponding to a sterilization time of 30 seconds), and the microwave frequency to 2450MHz. Sterilization effect test: According to the "National Food Safety Standard for Microbiological Examination of Food: Determination of Total Colony Count" (GB4789.2-2022), 25g of sterilized powder was taken, 225mL of sterile physiological saline was added, homogenized and cultured. The total colony count was ≤1000CFU / g, and Escherichia coli, mold and yeast were not detected, ensuring product safety. Reasons for choosing microwave sterilization: Low-temperature sterilization (powder temperature ≤60℃ during sterilization) avoids high-temperature damage to active ingredients (such as ginsenosides and sea buckthorn vitamin C), and sterilization is uniform (without dead corners), improving the retention rate of active ingredients by 30% compared to traditional moist heat sterilization (121℃). Step 7: Inert gas encapsulation Automatic quantitative packaging machine (model: DXD-40, Guangdong Songchuan) is used, with each bag containing 10g (error ±0.1g, in compliance with the "Regulations on the Supervision and Management of Quantitatively Packaged Commodities"). Nitrogen gas (purity ≥99.9%, food grade) is introduced during packaging at a flow rate of 10L / min to replace the air inside the bag (oxygen residue ≤1%, detected by gas chromatography). The heat sealing temperature is 180℃ and the time is 1.5 seconds. The heat sealing strength is ≥30N / 15mm (tested by a tensile testing machine). Shelf life verification: The packaged product was placed in a constant temperature and humidity chamber (model: HS-100, Shanghai Jinghong) at 25℃ and 60% relative humidity. Samples were taken at 0 months, 3 months, 6 months, 12 months and 18 months to test the content of puerarin and ginsenoside Rg1 (high performance liquid chromatography). The results showed that after 18 months, the content of puerarin decreased by ≤4% and the content of ginsenoside Rg1 decreased by ≤5%, which met the requirement of a shelf life of ≥18 months.

[0030] Processing methods for raw materials that are both food and medicine This invention designs a specific processing method for key raw materials (winter melon, perilla leaves, lotus leaves, and sea buckthorn fruit), solving the problems of "loss of effective ingredients and poor stability" in traditional processing methods, as detailed below: 1. Winter melon processing method Suitable raw materials: Fresh winter melon (processed within 24 hours after harvesting to avoid excessive moisture loss), with smooth skin, free from pests and diseases, and 70-80% ripe (overripe will have coarse fibers, while unripe will have too high water content). Processing steps: (1) Cleaning: Rinse the winter melon with running water for 3 minutes to remove surface dirt and sand, then soak it in 0.1% sodium hypochlorite solution for 5 minutes (disinfection), and finally rinse it with water for 2 minutes; (2) Cutting: After peeling and removing seeds, cut into 2cm square pieces with a stainless steel knife (to avoid oxidation of the iron knife), with an error of ±0.2cm; (3) Freeze-drying: Put the product into a vacuum freeze dryer and set the freeze-drying curve: first pre-freeze at -20℃ for 2 hours, then cool down to -40℃ for 4 hours, and finally sublimate and dry at 10Pa vacuum for 6 hours. The temperature throughout the process does not exceed 0℃. Quality standards: Freeze-dried winter melon is white to light yellow, without browning, with a moisture content of ≤5% and a dietary fiber retention rate of ≥90% (tested according to GB5009.88-2014 "Determination of Dietary Fiber in Food"). 2. Perilla Leaf Processing Method Suitable raw materials: tender perilla leaves (harvested in June-July, when the leaves are tender and have the highest volatile oil content), requiring the leaves to be intact, without yellow leaves or insect damage; Processing steps: (1) Selection: Remove yellow leaves, insect-infested leaves and impurities by hand; (2) Fixing: Put the leaves into a drum-type fixing machine, set the temperature to 120℃, the speed to 15r / min, and the time to 30 seconds. After fixing, the leaves will turn dark green. (3) Drying: After blanching, immediately put the product into a belt low-temperature dryer, set the temperature to 40-45℃, the wind speed to 1.5m / s, and the drying time to 2 hours, turning it over every 30 minutes; Quality standard: After drying, perilla leaves are dark green, without browning, with a moisture content of ≤8% and a volatile oil content of ≥0.4% (tested according to the volatile oil determination method under the "Perilla Leaf" item in the 2020 edition of the Chinese Pharmacopoeia).

[0031] 3. Lotus leaf processing methods Suitable raw materials: Fresh lotus leaves (harvested in July-August, when the lotus leaves are growing vigorously and have the highest alkaloid content), requiring the leaves to be intact, undamaged, and ≥30cm in diameter; Processing steps: (1) Cleaning: Rinse the lotus leaves with running water for 2 minutes to remove surface dust; (2) Blanching: Put the tea leaves into a steam blanching machine, set the steam pressure to 0.1 MPa and the time to 20 seconds. After blanching, the leaves will soften. (3) Drying: After blanching, place the product in a tray-type low-temperature dryer, set the temperature to 50℃, the wind speed to 1.2m / s, and the drying time to 3 hours; (4) Coarse grinding: After drying, grind with a universal grinder and pass through a 10-mesh sieve (particle size 1-2mm) to remove coarse fiber impurities; Quality standards: After drying, the lotus leaves are yellowish-green, without scorching, with a moisture content of ≤8% and a lotus leaf alkaloid content of ≥0.2% (detected by high performance liquid chromatography). 4. Seabuckthorn berry processing methods Suitable raw materials: fresh sea buckthorn fruit (harvesting time is September-October, maturity ≥90%, sugar content ≥15 Brix), requiring plump fruit, no rot, and no pests or diseases; Processing steps: (1) Cleaning: Rinse the sea buckthorn fruit with running water for 1 minute to remove surface impurities; (2) Juicing: Put the juice into a screw juicer (model: LZ-100, Zhejiang Yili), the juicing temperature is ≤30℃ (to avoid destroying vitamin C), filter to remove fruit pulp (the fruit pulp can be used for other products to avoid waste); (3) Spray drying: The sea buckthorn juice was put into a centrifugal spray dryer (model: LPG-5, Jiangsu Yutong), and the inlet air temperature was set to 180℃, the outlet air temperature to 80℃, the feed rate to 50mL / min, and the atomization pressure to 0.3MPa. Quality standards: The spray-dried sea buckthorn fruit powder is yellow to orange-yellow, free of lumps, with a moisture content of ≤5%, a vitamin C content of ≥200mg / 100g (tested according to GB5009.86-2016 "Determination of Vitamin C in Food"), and a total flavonoid content of ≥3.0% (detected by high performance liquid chromatography).

[0032] Application of compound compositions The application scenarios of the compound composition of this invention are based on "cold stagnation of qi and blood stasis constitution" and "suitability for special populations", clearly defining the scope of application, usage methods, efficacy judgment criteria and precautions to ensure safety and effectiveness: 1. Target audience and judgment criteria Target population: Individuals with cold-induced qi stagnation and blood stasis constitution. The diagnostic criteria are based on the "Classification and Determination of Traditional Chinese Medicine Constitution" (GB / T22458-2008), specifically manifested as follows: (1) Physical symptoms: cold hands and feet, numbness in limbs, easy fatigue, dizziness and headache, poor sleep quality (difficulty falling asleep or having many dreams); (2) Physical signs: dark complexion, purple lips, ecchymosis or petechiae on the tongue, and deep and hesitant pulse; (3) Detection indicators: Microcirculation detection (laser Doppler flowmeter) showed blood flow velocity in the extremities <10mm / s, blood viscosity (high shear) >5.5mPa・s, and carotid ultrasound showed plaques or intimal thickening; The following individuals are eligible for this supplementary treatment: those with breast nodules or thyroid nodules (nodule diameter <2cm, no malignant tendency). The criteria for diagnosis are: ultrasound examination shows that the nodule is benign (e.g., breast nodules BI-RADS2, thyroid nodules TI-RADS2), and is accompanied by local swelling and tenderness. Special suitable population: People with low blood pressure (systolic blood pressure <90mmHg) and anemia (hemoglobin <120g / L, male; <110g / L, female) need to adjust the dosage and take iron supplements. 2. How to use Regular dosage: Once a day, take 1 sachet (10g) each time, mix with 150-200mL of warm water at about 80℃ (to avoid high temperature destroying active ingredients) and take it. It is recommended to take it 30 minutes after breakfast (to reduce gastrointestinal irritation and facilitate absorption). Dosage for special populations (people with low blood pressure, anemia): (1) Adjust the ratio of raw materials: increase the amount of jujube from 6-12 parts to 12-15 parts, and increase the amount of ginseng from 5-10 parts to 8-12 parts (to enhance the effect of replenishing qi and increase blood pressure and hemoglobin). (2) Dosage: Take 1 packet once a day, mix with 80℃ warm water, and take it together with the red date and wolfberry blood tonic (ingredients: 10g red dates, 5g wolfberries, boiled in 200mL water). Take it 30 minutes after lunch (avoid taking it on an empty stomach to avoid dizziness). Recommended treatment course: The standard treatment course is 3 months (1 course). People with nodules are advised to take it continuously for 6 months. Stop taking the medication for 1 week after each course before starting the next course (to avoid long-term use that may cause the body to adapt). 3. Criteria for Judging Results Improved microcirculation: After one month of use, laser Doppler flowmeter showed that the blood flow velocity in the extremities was ≥15mm / s, with an improvement rate of ≥85%; after three months of use, the blood viscosity (high shear) was ≤5.0mPa・s, with an improvement rate of ≥89%. Detoxification effect: Within 20-60 minutes of taking the product, you will experience a clear detoxification sensation (such as itchy skin, oily urine, or loose stools), and the sensation will last for 2-3 days (after which it will gradually weaken, indicating that toxins are being gradually eliminated). Nodule improvement: After 3 months of use, ultrasound examination showed no increase in nodule volume, and the symptoms of local swelling and tenderness were reduced; after 6 months of use, some small nodules (diameter <1cm) shrank by ≥10% in volume, and the blood flow signal was enhanced (indicating improved local circulation). Effects on specific populations: After one month of use, systolic blood pressure in people with low blood pressure rose to 90-100 mmHg, and the incidence of dizziness decreased from 35% to below 5%; after two months of use, hemoglobin levels in people with anemia increased by ≥10g / L, and fatigue was reduced. Safety assessment: No gastrointestinal irritation (such as nausea or diarrhea) or allergic reactions (such as rash or itching) occurred during the course of treatment. Liver and kidney function tests (alanine aminotransferase and serum creatinine) were normal. 4. Precautions Contraindications: Pregnant women, breastfeeding women, children (<14 years old), those allergic to the raw materials of this invention (such as allergies to onions or ginseng), patients with malignant tumors, and those with severe liver or kidney dysfunction. People with caution: Patients with hypertension (while taking antihypertensive drugs), patients with diabetes (jujubes have a high sugar content, so blood sugar needs to be monitored), and patients with gastrointestinal ulcers (use with caution on an empty stomach, it is recommended to take after meals). Handling abnormal sensations: If you experience a significant burning sensation (lasting more than 30 minutes), diarrhea (more than 3 times a day), or worsening dizziness after taking the medication, you should stop taking the medication immediately and consult a professional to adjust the dosage (e.g., reduce to 5g / dose). Storage requirements: The product should be stored in a cool, dry place (temperature ≤25℃, relative humidity ≤60%), away from light. It should be consumed immediately after opening to avoid moisture and clumping.

[0033] The following four embodiments illustrate the implementation process of the present invention in detail. Each embodiment uses the above-described raw material processing and preparation methods, only adjusting the raw material ratio or process parameters to verify the effects under different scenarios: Example 1: Standard Conditioning Version (Suitable for ordinary cold-induced qi stagnation and blood stasis constitution) 1. Raw material ratio (parts by weight) 12 parts of kudzu root, 8 parts of five-year-old forest ginseng from Changbai Mountain (ginsenoside Rg 13.2%), 10 parts of freeze-dried winter melon from Shouguang, Shandong, 5 parts of perilla leaves from Xinghua, Jiangsu (volatile oil 0.45%), 8 parts of sea buckthorn fruit from Altay, Xinjiang (vitamin C 220mg / 100g), 6 parts of lotus leaves from Anqing, Anhui (lotus leaf alkaloid 0.22%), 10 parts of jujube from Xinjiang (sugar content 62Brix), 4 parts of cinnamon from Wuzhou, Guangxi (cinnamaldehyde 1.6%), 3 parts of onion extract (sulfides 1.3%), 12 parts of hawthorn from Qingzhou, Shandong (total flavonoids 5.1%), and 6 parts of dried ginger from Qianwei, Sichuan (gingerol 1.9%). 2. Preparation process Raw material pretreatment: freeze-dry winter melon (-40℃, 10Pa, 12 hours), blanch perilla leaves (120℃, 30 seconds) and then dry (42℃, 2 hours), blanch lotus leaves (110℃, 20 seconds) and then dry (50℃, 3 hours) and coarsely pulverize (1.5mm). Preparation of onion extract: supercritical CO2 extraction (30 MPa, 40 °C, 2 hours); Low-temperature baking: Kudzu root and ginseng are baked at 55℃ for 2.5 hours, cinnamon and dried ginger are baked at 65℃ for 2 hours, and jujubes and hawthorns are baked at 60℃ for 2.5 hours. Ultrafine pulverization: ginseng and cinnamon 38μm, kudzu root and hawthorn 42μm, the rest 40μm, nitrogen protection; Gradient mixing: First, mix the fat-soluble components at 30 rpm for 10 minutes, then mix the water-soluble components at 40 rpm for 15 minutes, with an RSD of 1.5%. Microwave sterilization: 800W, 0.5m / min, total bacterial count = 800CFU / g; Packaging: Nitrogen purity 99.95%, 10g per bag, oxygen residue = 0.8%. 3. Efficacy verification (60 subjects, 3 months) The microcirculation improvement rate was 86% (the blood flow velocity in the extremities increased from 9.2 mm / s to 16.5 mm / s). Blood viscosity improved by 89.5% (high shear rate decreased from 5.8 mPa·s to 4.8 mPa·s); The rate of experiencing detoxification symptoms was 90% (including itchy skin in 35%, oily urine in 40%, and loose stools in 25%). The incidence of adverse reactions was 0%. Example 2: Hypotension / Anemia Adapted Version 1. Raw material ratio (parts by weight) 12 parts of kudzu root, 10 parts of five-year-old forest ginseng from Changbai Mountain (ginsenoside Rg 13.3%), 10 parts of freeze-dried winter melon from Shouguang, Shandong, 5 parts of perilla leaves from Xinghua, Jiangsu (volatile oil 0.45%), 8 parts of sea buckthorn fruit from Altay, Xinjiang (vitamin C 220mg / 100g), 6 parts of lotus leaves from Anqing, Anhui (lotus leaf alkaloid 0.22%), 15 parts of jujube from Xinjiang (sugar content 62Brix), 4 parts of cinnamon from Wuzhou, Guangxi (cinnamaldehyde 1.6%), 3 parts of onion extract (sulfides 1.3%), 12 parts of hawthorn from Qingzhou, Shandong (total flavonoids 5.1%), and 6 parts of dried ginger from Qianwei, Sichuan (gingerol 1.9%). 2. Preparation process Same as Example 1, only the dosage of ginseng and jujube was adjusted. 3. Efficacy verification (30 subjects, 3 months) When systolic blood pressure rose from 85 mmHg to 95 mmHg, the incidence of dizziness decreased from 36.7% to 3.3%. Hemoglobin levels increased from 105 g / L (female) and 115 g / L (male) to 118 g / L and 125 g / L, respectively. Fatigue improvement rate was 90%, and sleep quality improvement rate was 86.7%. The incidence of adverse reactions was 0%. Example 3: Nodule Treatment Version (Suitable for people with breast / thyroid nodules) 1. Raw material ratio (parts by weight) 12 parts of kudzu root, 8 parts of five-year-old forest ginseng from Changbai Mountain (ginsenoside Rg 13.2%), 10 parts of freeze-dried winter melon from Shouguang, Shandong, 7 parts of perilla leaves from Xinghua, Jiangsu (volatile oil 0.48%), 10 parts of sea buckthorn fruit from Altay, Xinjiang (vitamin C 230mg / 100g), 6 parts of lotus leaves from Anqing, Anhui (lotus leaf alkaloid 0.22%), 10 parts of jujube from Xinjiang (sugar content 62Brix), 4 parts of cinnamon from Wuzhou, Guangxi (cinnamaldehyde 1.6%), 3 parts of onion extract (sulfides 1.3%), 14 parts of hawthorn from Qingzhou, Shandong (total flavonoids 5.2%), and 6 parts of dried ginger from Qianwei, Sichuan (gingerol 1.9%). 2. Preparation process Similar to Example 1, only the amounts of perilla leaves, sea buckthorn fruit, and hawthorn were adjusted, and the baking temperature was uniformly set at 60℃ (to avoid temperature differences affecting the gentle conditioning of people with nodules). 3. Efficacy verification (30 subjects, 6 months) The improvement rate of distending pain at the nodule site was 93.3%, and the improvement rate of tenderness was 90%. Ten small nodules (diameter <1cm) showed a 12% reduction in volume and a 76.7% increase in blood flow signal. No cases of nodule enlargement or malignant transformation; The incidence of adverse reactions was 0%. Example 4: High Blood Sugar Adapted Version (Supplementary Adaptation Scenarios) 1. Raw material ratio (parts by weight) 15 parts of kudzu root (puerarin 4.2%), 8 parts of five-year-old forest ginseng from Changbai Mountain (ginsenoside Rg 13.2%), 12 parts of freeze-dried winter melon from Shouguang, Shandong, 5 parts of perilla leaves from Xinghua, Jiangsu (volatile oil 0.45%), 8 parts of sea buckthorn fruit from Altay, Xinjiang (vitamin C 220mg / 100g), 8 parts of lotus leaves from Anqing, Anhui (lotus leaf alkaloid 0.23%), 6 parts of jujube from Xinjiang (sugar content 62Brix), 4 parts of cinnamon from Wuzhou, Guangxi (cinnamaldehyde 1.6%), 3 parts of onion extract (sulfides 1.3%), 15 parts of hawthorn from Qingzhou, Shandong (total flavonoids 5.3%), and 4 parts of dried ginger from Qianwei, Sichuan (gingerol 1.8%). 2. Preparation process Similar to Example 1, only the dosage of kudzu root, winter melon, lotus leaf, hawthorn, and dried ginger was adjusted, and the microwave sterilization power was reduced to 750W (to avoid high temperature affecting lotus leaf alkaloids, which have an auxiliary effect in lowering blood sugar). 3. Efficacy verification (30 subjects, 3 months) Fasting blood glucose decreased from 7.2 mmol / L to 6.4 mmol / L, and 2-hour postprandial blood glucose decreased from 11.5 mmol / L to 9.8 mmol / L; Low-density lipoprotein cholesterol decreased from 3.8 mmol / L to 3.2 mmol / L; No hypoglycemic reaction, blood glucose fluctuation range ≤0.5mmol / L; The incidence of adverse reactions was 0%.

[0034] This invention, through clinical trials involving 150 subjects (Examples 1-4) and combined with laboratory tests (content of active ingredients, microorganisms, stability), has demonstrated the following effects: High retention rate of active ingredients: The retention rate of key ingredients such as puerarin, ginsenoside Rg1, and lotus leaf alkaloids is ≥90%, and the bioavailability is 2.5 times higher than that of traditional decoction method; Significant therapeutic effects: Microcirculation improvement rate ≥85%, blood viscosity improvement rate ≥89%, discomfort improvement rate at nodule sites ≥90%, and dizziness incidence rate in special populations (hypotension, anemia) ≤5%; Excellent safety profile: Acute toxicity test LD50 > 10g / kg (practically non-toxic), heavy metal (lead, mercury, arsenic) content meets GB2762 standard, adverse reaction rate 0%; Good stability: Shelf life ≥ 18 months, after 18 months the content of active ingredients decreases by ≤ 5%, and there is no clumping or mold.

[0035] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medicinal and edible compound composition with three-way effects, characterized in that, It is composed of the following raw materials in parts by weight: 8-15 parts kudzu root, 5-10 parts ginseng, 6-12 parts winter melon, 3-8 parts perilla leaf, 5-10 parts sea buckthorn fruit, 4-8 parts lotus leaf, 6-12 parts jujube, 3-6 parts cinnamon, 2-5 parts onion extract, 8-15 parts hawthorn, and 4-8 parts dried ginger; the onion extract contains ≥1.2% sulfide, and the ginseng contains ≥3.0% ginsenoside Rg1.

2. A method for preparing the compound composition as described in claim 1, characterized in that, Includes the following steps: (1) Raw material pretreatment: Winter melon is freeze-dried under vacuum, perilla leaves are blanched and then dried at low temperature, and lotus leaves are blanched, then dried at low temperature and crushed into coarse powder. (2) Extraction of active ingredients: The active ingredients of onions are extracted using supercritical CO2 extraction technology; (3) Low-temperature baking: The pre-treated kudzu root, ginseng, jujube, cinnamon, dried ginger and hawthorn are baked separately, and the moisture content of the raw materials after baking is controlled to be ≤6%; (4) Ultrafine grinding: Grind the baked raw materials to a particle size ≤45μm; (5) Gradient mixing: First mix the fat-soluble components, then add the water-soluble components, and the mixing uniformity is ≥98%; (6) Microwave sterilization: Microwave sterilization is used to ensure that the total number of colonies is ≤1000 CFU / g; (7) Packaging: Inert gas is used for packaging, and each bag contains 10g.

3. A method for processing medicinal and edible raw materials for three-way regulation, characterized in that, Regarding the raw materials in the compound composition of claim 1: Winter melon: Fresh winter melon is peeled and seeded, then cut into 2cm cubes. It is then processed using vacuum freeze-drying technology at a temperature of -40℃ and a vacuum degree of 10Pa. The moisture content after freeze-drying is ≤5%. Perilla leaves: Select tender perilla leaves harvested in the current year, blanch them at 120℃ for 30 seconds, and then dry them at a low temperature of 40-45℃. After drying, the moisture content is ≤8% and the volatile oil content is ≥0.4%. Lotus leaves: Fresh lotus leaves harvested in July and August are selected. After blanching, they are dried at a low temperature of 50℃ and crushed into coarse powder with a particle size of 1-2mm. The alkaloid content of lotus leaves is ≥0.2%.

4. An application of the compound composition as described in claim 1, characterized in that, It is used to improve microcirculation disorders and vascular blockage caused by cold stagnation and blood stasis, and to remove heavy metals and low-density lipoprotein from the blood; it can also be used to help improve local blockage caused by breast nodules and thyroid nodules, and a differentiated detoxification sensation can be seen within 20-60 minutes after taking it.

5. The compound composition according to claim 1, characterized in that, The ginseng is selected from five-year-old forest-grown ginseng; the hawthorn is selected from Shandong Dajinxing hawthorn with a total flavonoid content ≥5.0%; the cinnamon is selected from Guangxi cinnamon with a cinnamaldehyde content ≥1.5%; the dried ginger is selected from Sichuan Qianwei dried ginger with a gingerol content ≥1.8%; and the jujube is selected from Xinjiang grey jujube with a sugar content ≥60%.

6. The preparation method according to claim 2, characterized in that, In step (3), the low-temperature baking is carried out in stages with temperature control: kudzu root and ginseng are baked at 55℃ for 2-3 hours, cinnamon and dried ginger are baked at 65℃ for 2 hours, and jujube and hawthorn are baked at 60℃ for 2.5 hours; in step (4), nitrogen is introduced during ultrafine grinding to prevent oxidation, and the particle size of ginseng and cinnamon after grinding is controlled at 35-40μm, and the particle size of kudzu root and hawthorn after grinding is controlled at 40-45μm.

7. The raw material processing method according to claim 3, characterized in that, The processing method of the sea buckthorn fruit is as follows: select fresh sea buckthorn fruit with a maturity of ≥90% to extract juice, and use spray drying technology to make powder. The spray drying inlet air temperature is 180℃ and the outlet air temperature is 80℃, and the vitamin C content after powdering is ≥200mg / 100g.

8. The application according to claim 4, characterized in that, When used for people with low blood pressure and anemia, the dosage of jujube in the compound composition of claim 1 is adjusted to 12-15 parts and the dosage of ginseng is adjusted to 8-12 parts. When taken together with a jujube and wolfberry blood-tonifying agent, the incidence of dizziness can be reduced to less than 5%.

9. The compound composition according to claim 1, characterized in that, The differentiated detoxification sensations include: sweat gland detoxification with itchy and red skin, urine detoxification with a fishy odor and oily surface, or detoxification with smelly and loose stools; and after taking it, a heat sensation will spread from the head to the limbs, lasting for 20-30 minutes.

10. The preparation method according to claim 2, characterized in that, The specific parameters for gradient mixing in step (5) are as follows: first, put cinnamon powder, onion extract, and dried ginger powder into a three-dimensional mixer and mix at 30 r / min for 10 minutes; then add kudzu root powder, ginseng powder, jujube powder, hawthorn powder, sea buckthorn fruit powder, and lotus leaf powder, and adjust the speed to 40 r / min and continue mixing for 15 minutes; in step (7), the inert gas is nitrogen with a purity of ≥99.9%, and the shelf life of the product after packaging is ≥18 months, and the content of puerarin and ginsenoside Rg1 decreases by ≤5% during the shelf life.