< 11 > C-sodium acetate synthesis system and < 11 > C-sodium acetate synthesis method

Abstract

The invention discloses a < 11 > C-sodium acetate synthesis system and method, and relates to the technical field of radiopharmaceutical automatic synthesis, the synthesis system comprises a first reagent module, a second reagent module, a third reagent module, a primary hydrolysis module, a secondary hydrolysis module and a pipetting module; the synthesis method comprises the following steps: S1, loading reagents; S2, filling nitrogen into each reagent bottle; S3, transferring a Grignard reagent into a reaction tube; S4, feeding < 11 > CO2 gas into the reaction tube to complete a hydrolysis reaction, S6, transferring a reaction solution into an extraction bottle, S7, transferring a NaHCO3 solution into the extraction bottle to complete secondary hydrolysis, S8, carrying out vacuum heating on the extraction bottle to generate a product, S9, diluting the product, and S10, transferring the product into a product bottle. During synthesis, the Grignard reagent is transferred to the reaction tube in a negative-pressure pipetting manner, so that compared with the prior art, the Grignard reagent can be effectively prevented from being inactivated; the Grignard reagent absorbs < 11 > CO2 in a normal temperature state, so that the complexity of the synthesis process is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of automatic synthesis of radiopharmaceuticals, and in particular to a 11 C-sodium acetate synthesis system and method. BACKGROUND

[0002] Diagnosis and treatment of diseases using radiopharmaceuticals can comprehensively reflect the genetic, molecular, metabolic and functional state of the lesion, and can provide early insight into disease information at the molecular level, thereby achieving early diagnosis and precise treatment. Using an automatic radiopharmaceutical synthesis module can effectively reduce the radiation dose to which medical personnel are exposed during the preparation process, thereby providing protection.

[0003] Currently, the main imaging diagnostic method used by domestic medical institutions is positron emission tomography (PET) based on 18 F drugs or 11 C drug imaging agents, wherein 11 C-sodium acetate has strong specificity for prostate cancer and is of great value in the diagnosis, staging and recurrence monitoring of prostate cancer. In order to reduce personnel exposure to radiation, the use of an automatic radiopharmaceutical synthesis module is an inevitable trend. However, the current automatic radiopharmaceutical synthesis module typically prepositions Grignard reagent in the reaction tube, which is easily deactivated by reaction with oxygen, water, carbon dioxide and the like in the air. SUMMARY

[0004] In view of the problem that the Grignard reagent prepositioned in the reaction tube in the prior art is easily deactivated by contact with air, the present application provides a 11 C-sodium acetate synthesis system and method.

[0005] The present application provides the following technical solution: a 11 C-sodium acetate synthesis system, comprising: A first reagent module comprising a first three-way valve, a second three-way valve, a third three-way valve, a fourth three-way valve and a fifth three-way valve connected in series, the fifth three-way valve being connected to a feeder; A second reagent module comprising a sixth three-way valve, a seventh three-way valve, an eighth three-way valve and a ninth three-way valve connected in series, the remaining two interfaces of the sixth three-way valve being connected to a first reagent bottle and the fifth three-way valve, respectively, and the eighth three-way valve being connected to an exhaust pipe; A third reagent module comprising a thirteenth three-way valve, an eleventh three-way valve, a twelfth three-way valve, a tenth three-way valve and a fourteenth three-way valve connected in series, the thirteenth three-way valve being connected to a second reagent bottle, the eleventh three-way valve being connected to a third reagent bottle, and the fourteenth three-way valve being connected to an exhaust pipe; A primary hydrolysis module includes a carbon dioxide capture device and a reaction tube. The carbon dioxide capture device includes a cooling container, an annular tube, a drive device for driving the annular tube in and out of the cooling container, and a carbon dioxide input tube connected to the first three-way valve. The two ends of the annular tube are respectively connected to the first three-way valve and the third three-way valve, and the fourth three-way valve and the seventh three-way valve are both connected to the reaction tube. The secondary hydrolysis module includes an extraction bottle, a ninth three-way valve connected to the bottom of the extraction bottle, a thirteenth three-way valve connected to the extraction bottle, and the extraction bottle is equipped with a heater; The pipetting module includes a negative pressure generating device, an inert gas source, and a product bottle; the negative pressure generating device is connected to a multi-way valve, two ports of which are respectively connected to a fifteenth three-way valve and the product bottle, and the other two ports of the fifteenth three-way valve are respectively connected to the product bottle and the fourteenth three-way valve; the inert gas source is connected to a seventeenth three-way valve, and one port of the seventeenth three-way valve is connected to a second three-way valve.

[0006] Preferably, the cooling container is a liquid nitrogen container with an open top, and the driving device is a lift connected to the annular pipe.

[0007] Preferably, the first three-way valve, the second three-way valve, the third three-way valve, the fourth three-way valve, and the fifth three-way valve are connected as one unit; the sixth three-way valve, the seventh three-way valve, the eighth three-way valve, and the ninth three-way valve are connected as one unit; and the thirteenth three-way valve, the eleventh three-way valve, the fourteenth three-way valve, the thirteenth three-way valve, and the fourteenth three-way valve are connected as one unit.

[0008] Preferably, the synthesis system further includes a housing, and multiple three-way valves connected as one unit are disposed on the outer surface of the housing.

[0009] Preferably, the feeder is an injection pump.

[0010] Preferably, the inert gas source is also connected to a shut-off valve and a flow meter, and the carbon dioxide input pipe is equipped with a shut-off valve.

[0011] Preferably, each exhaust pipe is equipped with a one-way valve.

[0012] Preferably, the twelfth three-way valve is also connected to a fourth reagent bottle.

[0013] Preferably, the fifteenth three-way valve is also connected to a sixteenth three-way valve, the sixteenth three-way valve is connected to the product bottle, and the sixteenth three-way valve is also connected to the seventeenth three-way valve.

[0014] A sort of 11 C-sodium acetate synthesis method, applied to 11 A C-sodium acetate synthesis system, characterized by comprising the following steps: S1, filling hydrochloric acid into the feeder, filling Grignard reagent into the first reagent bottle, the Grignard reagent is CH3MgBr THF solution, filling NaHCO3 solution into the second reagent bottle, filling physiological saline into the third reagent bottle, and purging all pipelines with inert gas to remove air in the synthesis system; S2, filling inert gas into the first reagent bottle, the second reagent bottle and the third reagent bottle respectively to increase the pressure in the bottle; S3, using the negative pressure generating device to suck the gas in the reaction tube to transfer the Grignard reagent in the first reagent bottle to the reaction tube; S4, the annular tube enters the cooling container, and the 11 CO2 is input into the annular tube through the carbon dioxide input pipe to be sublimed into dry ice; after the annular tube is removed from the cooling container, the dry ice is sublimed into gas, and the sublimed 11 CO2 gas is sent into the reaction tube to be absorbed by the Grignard reagent; S5, starting the feeder to add hydrochloric acid into the reaction tube to complete the hydrolysis reaction; S6, inserting the pipeline connected with the seventh three-way valve and the reaction tube into the bottom of the reaction tube, and purging nitrogen into the reaction tube to move the reaction liquid in the reaction tube to the extraction bottle; S7, using the negative pressure generating device to suck the gas in the extraction bottle to suck the NaHCO3 solution from the second reagent bottle into the extraction bottle for secondary hydrolysis; S8, heating the extraction bottle in a vacuum environment to generate a product; S9, using the negative pressure generating device to suck the gas in the extraction bottle to suck the physiological saline in the third reagent bottle into the extraction bottle to dilute the product; S10, using the negative pressure generating device to suck the gas in the product bottle to suck the product dilution liquid in the extraction bottle into the product bottle.

[0015] The beneficial effects of the present application are: the Grignard reagent is moved to the reaction tube in the form of negative pressure pipetting during synthesis, which can effectively avoid the inactivation of the Grignard reagent compared with the prior art; the Grignard reagent absorbs 11 CO2 at room temperature, which reduces the complexity of the synthesis process; the multiple three-way valves are integrated and arranged on the outer surface of the shell, which is convenient for pipeline leak detection, cleaning and replacement. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is a schematic view of an embodiment of the synthesis system.

[0017] Reference signs: 1-cooling container, 2-annular tube, 3-driving device, 4-negative pressure generating device, 5-product bottle, A1-first reagent bottle, B1-second reagent bottle, B2-third reagent bottle, B3-fourth reagent bottle, C1-reaction tube, C3-extraction bottle, L1-feeder, V1-shutoff valve, V2-seventeenth three-way valve, V3-first three-way valve, V4-second three-way valve, V5-third three-way valve, V6-fourth three-way valve, V7-fifth three-way valve, V8-sixth three-way valve, V9-seventh three-way valve, V10-eighth three-way valve, V11-ninth three-way valve, V13-thirteenth three-way valve, V14-eleventh three-way valve, V15-twelfth three-way valve, V16-tenth three-way valve, V17-fourteenth three-way valve, V22-fifteenth three-way valve, V24-sixteenth three-way valve, V28-multichannel valve, V29-shutoff valve. DETAILED DESCRIPTION

[0018] The embodiments of the present application will be described in more detail with reference to the drawings and reference signs, so that those skilled in the art can implement the present application after reading the present specification. It should be understood that the specific examples described herein are only used to explain the present application, and are not intended to limit the present application.

[0019] Example 1

[0020] The present application provides a C-sodium acetate synthesis system as shown in Figure 1 11 The C-sodium acetate synthesis system comprises a first reagent module, a second reagent module, a third reagent module, a primary hydrolysis module, a secondary hydrolysis module, and a pipetting module.

[0021] The first reagent module comprises a first three-way valve V3, a second three-way valve V4, a third three-way valve V5, a fourth three-way valve V6, and a fifth three-way valve V7 connected in sequence. The first to fifth three-way valves are integrated into one, forming a five-connected three-way valve, and the five-connected three-way valve is arranged on the outer surface of the synthesis system shell, facilitating leak detection, cleaning, and replacement. The fifth three-way valve V7 is connected with a feeder L1. The feeder L1 is a feeding device capable of storing and actively discharging reagents, such as a syringe pump, for delivering a reagent to the reaction tube C1.

[0022] ​The second reagent module comprises a sixth three-way valve V8, a seventh three-way valve V9, an eighth three-way valve V10, and a ninth three-way valve V11 connected in sequence. Similarly, the sixth to ninth three-way valves are integrated into one and arranged on the outer surface of the synthesis system shell. The remaining two interfaces of the sixth three-way valve V8 are respectively connected to the first reagent bottle A1 and the fifth three-way valve V7. The first reagent bottle A1 is used to load Grignard reagent at the beginning of the synthesis, and the Grignard reagent is a THF solution of CH3MgBr. The eighth three-way valve V10 is connected with an exhaust pipe for discharging waste gas to release pressure, and the exhaust pipe is usually also provided with a one-way valve or a stop valve to prevent external gas from entering.

[0023] The third reagent module comprises a thirteenth three-way valve V13, an eleventh three-way valve V14, a twelfth three-way valve V15, a tenth three-way valve V16, and a fourteenth three-way valve V17 connected in sequence. Similarly, the tenth to fourteenth three-way valves are integrated into one to form a five-connected three-way valve, and the five-connected three-way valve is arranged on the outer surface of the synthesis system shell. The thirteenth three-way valve V13 is connected with a second reagent bottle B1 for loading NaHCO3 solution. The eleventh three-way valve V14 is connected with a third reagent bottle B2 for loading physiological saline as a diluent. The twelfth three-way valve V15 is connected with a fourth reagent bottle B3 as a standby reagent bottle. The fourteenth three-way valve V17 is connected with an exhaust pipe for discharging waste gas to release pressure, and the exhaust pipe is usually also provided with a one-way valve or a stop valve to prevent external gas from entering.

[0024] The primary hydrolysis module comprises a carbon dioxide capturing device and a reaction tube C1. The carbon dioxide capturing device provides CO2 gas for the reaction tube C1 to complete the hydrolysis reaction in the reaction tube C1. 11 The carbon dioxide capturing device comprises a cooling container 1, an annular tube 2, a driving device 3 for driving the annular tube 2 to enter and exit the cooling container 1, and a carbon dioxide input pipe connected with the first three-way valve V3, and the carbon dioxide input pipe is usually also provided with a stop valve V29. In this embodiment, the cooling container 1 can be a liquid nitrogen container with an open top, and the driving device 3 can be an elevator fixed with the annular tube 2. The annular tube 2 is connected to the first three-way valve V3 and the third three-way valve V5 at both ends, and a flexible pipe is usually used. The reaction tube C1 is a container for the hydrolysis reaction, and the fourth three-way valve V6 and the seventh three-way valve V9 are both connected to the reaction tube C1.

[0025] The secondary hydrolysis module comprises an extraction bottle C3, and the secondary hydrolysis reaction is completed in the extraction bottle C3. The ninth three-way valve V11 is connected to the extraction bottle C3 through a pipe extending to the bottom of the extraction bottle C3, and the tenth three-way valve V16 is connected to the extraction bottle C3. The extraction bottle C3 is provided with a heater.

[0026] The pipetting module utilizes gas or liquid in the positive or negative pressure transfer system, including a negative pressure generating device 4, an inert gas source, and a product bottle 5. The negative pressure generating device 4 can be a vacuum pump for generating negative pressure to suck gas or liquid in the pipeline, which is connected with a multi-way valve V28, two interfaces of the multi-way valve V28 are connected to a fifteenth three-way valve V22 and the product bottle 5 respectively, one interface of the fifteenth three-way valve V22 is connected to a sixteenth three-way valve V24, and the other interface is connected to the fourteenth three-way valve V17, and the sixteenth three-way valve V24 is connected to the product bottle 5. The inert gas source is connected to a seventeenth three-way valve V2, and the other two interfaces of the seventeenth three-way valve V2 are connected to the second three-way valve V4 and the sixteenth three-way valve V24 respectively, so as to push gas or liquid in the pipeline by positive pressure. The inert gas source is also connected with a stop valve V1 and a flow meter. The inert gas source is usually a nitrogen source.

[0027] As shown in Figure 1 , the connection mode between the above components is usually pipeline connection allowing gas or liquid to pass through, or threaded connection of the interface of a component with the interface of another component. Figure 1 The three-way valves not marked in the figure are in the default communication state and are closed to the external environment.

[0028] Example 2

[0029] A 11 method for synthesizing sodium C-acetate, applied to the 11 synthesis system of sodium C-acetate, including the following steps. In each gas or liquid delivery process, all other branches are in the closed state except the pipeline connection mentioned.

[0030] S1, fill the hydrochloric acid into the feeder L1, fill the Grignard reagent into the first reagent bottle A1 in the glove box with nitrogen atmosphere, the first reagent bottle A1 is also filled with nitrogen, the Grignard reagent is a CH3MgBr solution in THF, fill the NaHCO3 solution into the second reagent bottle B1, and fill the physiological saline into the third reagent bottle B2; then install each reagent bottle to the corresponding position of the synthesis system.

[0031] Open the nitrogen source and the negative pressure generating device, and introduce nitrogen into the synthesis system to clean all pipelines and discharge air.

[0032] S2, nitrogen gas is input from the nitrogen source, through the stop valve V1, the seventeenth three-way valve V2, the second to sixth three-way valves (V3-V8) into the first reagent bottle A1; nitrogen gas is input from the nitrogen source, through the stop valve V1, the seventeenth three-way valve V2, the second to thirteenth three-way valves (V3-V13) into the second reagent bottle B1; nitrogen gas is input from the nitrogen source, through the stop valve V1, the seventeenth three-way valve V2, the second to eleventh three-way valves (V3-V14) into the third reagent bottle B2. The pressure in the first, second and third reagent bottles increases, and is in a positive pressure state.

[0033] S3, the negative pressure generating device is started, the gas in the reaction tube C1 is discharged in turn through the seventh to fifteenth three-way valves, the multi-way valve V28, the negative pressure generating device 4, and under the influence of the negative pressure and the positive pressure in the first reagent bottle A1, the Grignard reagent in the first reagent bottle A1 enters the reaction tube C1 in turn through the sixth three-way valve V8, the fifth three-way valve V7 and the fourth three-way valve V6. In this environment, the Grignard reagent does not contact with air, effectively avoiding inactivation.

[0034] S4, the driving device 3 sinks the annular tube 2 into the cooling container 1, opens the stop valve V29, and uses the cyclotron to accelerate the gas in the annular tube 2 to a high speed, and the gas is discharged from the annular tube 2 through the seventh to fifteenth three-way valves, the multi-way valve V28, the negative pressure generating device 4, and the stop valve V29. 14 N(p, α) 11 C reaction generated 11 CO2 is input from the carbon dioxide input pipe, enters the annular tube 2 through the first three-way valve V3, and is condensed into dry ice; after the driving device 3 moves the annular tube 2 out of the cooling container 1, the dry ice sublimates into gas, and nitrogen gas is input into the annular tube 2 through the stop valve V1, the seventeenth three-way valve V2, the second three-way valve V4 and the first three-way valve V3, and 11 CO2 gas is sent into the reaction tube C1 through the third three-way valve V5 and the fourth three-way valve V6 and is absorbed by the Grignard reagent; the excess gas in the reaction tube C1 is discharged from the seventh three-way valve V9, the eighth three-way valve V10 and the exhaust pipe.

[0035] S5, the feeder L1 is started, and hydrochloric acid is input into the reaction tube C1 through the fifth three-way valve V7 and the fourth three-way valve V6 to complete the hydrolysis reaction by using the positive pressure, and the excess gas is discharged from the seventh three-way valve V9, the eighth three-way valve V10 and the exhaust pipe.

[0036] S6, the pipeline connecting the seventh three-way valve V9 and the reaction tube C1 is inserted into the bottom of the reaction tube C1, nitrogen gas is input into the reaction tube C1 through the stop valve V1, the seventeenth three-way valve V2, the second to fourth three-way valves, and the reaction liquid is moved to the extraction bottle C3 through the seventh to thirteenth three-way valves, and the excess gas in the extraction bottle C3 is discharged from the fourteenth three-way valve V17 and the exhaust pipe.

[0037] S7, the negative pressure generating device is started, the gas in the extraction bottle C3 is discharged through the tenth three-way valve V16, the fourteenth three-way valve V17, the fifteenth three-way valve V22, the multi-way valve V28 and the negative pressure generating device, under the action of the negative pressure and the positive pressure in the second reagent bottle, the NaHCO3 solution enters the extraction bottle C3 through the thirteenth three-way valve V13 and the ninth three-way valve V11 to carry out secondary hydrolysis.

[0038] S8, the negative pressure generating device is started, the gas in the extraction bottle C3 is discharged through the tenth three-way valve V16, the fourteenth three-way valve V17, the fifteenth three-way valve V22, the multi-way valve V28 and the negative pressure generating device, a vacuum environment is formed, the ninth three-way valve V11 and the tenth three-way valve V16 are closed to seal the extraction bottle C3, and the extraction bottle C3 is heated to generate a product 11 C-sodium acetate.

[0039] S9, the negative pressure generating device is started, the gas in the extraction bottle C3 is discharged through the tenth three-way valve V16, the fourteenth three-way valve V17, the fifteenth three-way valve V22, the multi-way valve V28 and the negative pressure generating device, under the action of the negative pressure and the positive pressure in the third reagent bottle, the physiological saline in the third reagent bottle B2 enters the extraction bottle C3 through the eleventh three-way valve V14, the thirteenth three-way valve V13 and the ninth three-way valve V11 to dilute the product.

[0040] S10, the negative pressure generating device is started, the gas in the product bottle 5 flows out through the multi-way valve V28 and the negative pressure generating device, and the product in the extraction bottle C3 enters the product bottle through the ninth to sixteenth three-way valves.

[0041] The above is one or more embodiments of the application, which is described in more detail and in more detail, but cannot be understood as limiting the scope of the patent of the application. It should be noted that for those skilled in the art, without departing from the concept of the application, a number of modifications and improvements can be made, which are within the scope of protection of the application. Therefore, the protection scope of the patent of the application should be subject to the appended claims.

Claims

1. A kind 11 C-sodium acetate synthesis system, characterized in that... include: The first reagent module includes a first three-way valve, a second three-way valve, a third three-way valve, a fourth three-way valve, and a fifth three-way valve connected in sequence, wherein the fifth three-way valve is connected to a feeder; The second reagent module includes a sixth three-way valve, a seventh three-way valve, an eighth three-way valve, and a ninth three-way valve connected in sequence. The other two ports of the sixth three-way valve are respectively connected to the first reagent bottle and the fifth three-way valve. The eighth three-way valve is connected to an exhaust pipe. The third reagent module includes a 13th-way valve, an 11th-way valve, a 12th-way valve, a 13th-way valve, and a 14th-way valve connected in sequence. The 13th-way valve is connected to a second reagent bottle, the 11th-way valve is connected to a third reagent bottle, and the 14th-way valve is connected to an exhaust pipe. A primary hydrolysis module includes a carbon dioxide capture device and a reaction tube. The carbon dioxide capture device includes a cooling container, an annular tube, a drive device for driving the annular tube in and out of the cooling container, and a carbon dioxide input tube connected to the first three-way valve. The two ends of the annular tube are respectively connected to the first three-way valve and the third three-way valve, and the fourth three-way valve and the seventh three-way valve are both connected to the reaction tube. The secondary hydrolysis module includes an extraction bottle, a ninth three-way valve connected to the bottom of the extraction bottle, a thirteenth three-way valve connected to the extraction bottle, and the extraction bottle is equipped with a heater; The pipetting module includes a negative pressure generating device, an inert gas source, and a product bottle; the negative pressure generating device is connected to a multi-way valve, two ports of which are respectively connected to a fifteenth three-way valve and the product bottle, and the other two ports of the fifteenth three-way valve are respectively connected to the product bottle and the fourteenth three-way valve; the inert gas source is connected to a seventeenth three-way valve, and one port of the seventeenth three-way valve is connected to a second three-way valve.

2. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The cooling container is a liquid nitrogen container with an open top, and the driving device is a lift connected to the annular pipe.

3. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The first three-way valve, the second three-way valve, the third three-way valve, the fourth three-way valve, and the fifth three-way valve are connected as one unit; the sixth three-way valve, the seventh three-way valve, the eighth three-way valve, and the ninth three-way valve are connected as one unit; the thirteenth three-way valve, the eleventh three-way valve, the fourteenth three-way valve, the thirteenth three-way valve, and the fourteenth three-way valve are connected as one unit.

4. The one according to claim 3 11 C-sodium acetate synthesis system, characterized in that... The synthesis system also includes a housing, and multiple three-way valves connected as one unit are all disposed on the outer surface of the housing.

5. The method according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The feeder is an injection pump.

6. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The inert gas source is also connected to a shut-off valve and a flow meter, and the carbon dioxide input pipe is equipped with a shut-off valve.

7. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... All exhaust pipes are equipped with one-way valves.

8. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The twelfth three-way valve is also connected to a fourth reagent bottle.

9. The one according to claim 1 11 C-sodium acetate synthesis system, characterized in that... The fifteenth three-way valve is also connected to the sixteenth three-way valve, which is connected to the product bottle, and the sixteenth three-way valve is also connected to the seventeenth three-way valve.

10. A kind 11 The method for synthesizing C-sodium acetate, as described in any one of claims 1 to 9 11 C-sodium acetate synthesis system, characterized in that... Includes the following steps: S1, hydrochloric acid is loaded into the feeder, Grignard reagent is loaded into the first reagent bottle in an inert gas atmosphere, the Grignard reagent is CH3MgBr in THF solution, NaHCO3 solution is loaded into the second reagent bottle, and physiological saline is loaded into the third reagent bottle; inert gas is introduced into the synthesis system to purge all pipelines and remove air. S2, inert gas is introduced into the first reagent bottle, the second reagent bottle, and the third reagent bottle respectively to increase the pressure inside the bottles; S3, using a negative pressure generating device to draw gas from the reaction tube, and transfer the Grignard reagent in the first reagent bottle to the reaction tube; S4, the annular pipe enters the cooling container, and... 11 CO2 is introduced into the loop tube via the carbon dioxide inlet pipe and sublimates into dry ice. After the loop tube is removed from the cooling container, the dry ice sublimates into gas, and an inert gas is introduced to dissolve the sublimated dry ice. 11 CO2 gas is introduced into the reaction tube and absorbed by the Grignard reagent; S5, the feeder is started, and hydrochloric acid is added to the reaction tube to complete the hydrolysis reaction; S6, insert the pipe connecting the seventh three-way valve and the reaction tube into the bottom of the reaction tube, and introduce nitrogen gas into the reaction tube to transfer the reaction liquid in the reaction tube to the extraction bottle; S7. Using a negative pressure generating device, the gas in the extraction bottle is drawn, and the NaHCO3 solution is drawn from the second reagent bottle into the extraction bottle for secondary hydrolysis. S8, the extraction flask is heated in a vacuum environment to generate the product; S9, using a negative pressure generating device to draw gas from the extraction bottle, and draw physiological saline from the third reagent bottle into the extraction bottle to dilute the product; S10, using a negative pressure generating device to draw gas from the product bottle, and draw the diluted product liquid from the extraction bottle into the product bottle.

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