Traditional Chinese medicine formula for treating eczema, traditional Chinese medicine preparation and preparation method of traditional Chinese medicine preparation

Abstract

The invention belongs to the technical field of traditional Chinese medicine, discloses a traditional Chinese medicine formula for treating eczema, a traditional Chinese medicine preparation and a preparation method thereof, and aims to solve the problems that an existing medicine for treating eczema is remarkable in side effect, easy to relapse, poor in permeability and the like. The traditional Chinese medicine formula comprises the following components in parts by weight: 30-70 parts of liquorice, 30-70 parts of lithospermum erythrorhizon, 30-70 parts of angelica sinensis and 10-30 parts of radix sophorae flavescentis. According to the traditional Chinese medicine ointment disclosed by the invention, the preparation process is improved, the medicinal materials are fried in stages, and volatile components are added under a low-temperature condition, so that the extraction efficiency and the stability of the effective components of the medicines are improved, the transdermal permeation enhancing effect of the ointment is ensured, and the ointment has a good application prospect. The traditional Chinese medicine composition has the advantages of remarkable curative effect, low recurrence, no dependence, low cost and the like.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine formula, preparation and preparation method for treating eczema. Background Technology

[0002] Eczema is a chronic inflammatory skin disease characterized by intense itching caused by a variety of internal and external factors. Clinically, it is mainly characterized by erythema, exudation, and itching. It is divided into three stages: acute, subacute, and chronic. Chronic eczema often develops from repeated relapses of acute or subacute eczema, or it may start as chronic eczema. Chronic eczema is characterized by thickened and infiltrated skin in the affected area, brownish-red color or pigmentation, rough surface, covered with scales, or crusting due to scratching. It is characterized by intense itching, an unpredictable course, easy recurrence, and a long duration of treatment.

[0003] Currently, clinical treatment for this type of disease includes both Western and Traditional Chinese Medicine (TCM) approaches, often combining internal and external treatments. Western medicine treatment relies on hormones and immunosuppressants, which have significant side effects with long-term use. Long-term use of Western medicine hormone ointments (such as glucocorticoids) can easily lead to side effects such as skin atrophy and telangiectasia, and there is a relapse phenomenon after discontinuation of the medication. Non-hormonal drugs (such as tacrolimus ointment and criboroxone ointment) are expensive, placing a heavy financial burden on patients. Moreover, some of these drugs are potent and highly irritating to the skin, resulting in poor treatment effects. Patients still scratch due to itching and pain at the eczema site, leading to further infections. Existing TCM preparations generally suffer from slow onset of action, complex preparation processes, and short shelf life.

[0004] Traditional Chinese medicine believes that eczema is related to damp-heat accumulation in the skin and blood deficiency and wind-dryness. It should be treated from the inside out, addressing both the symptoms and the root cause, to avoid recurrence due to treating only the symptoms and not the root cause. To this end, a new Chinese medicine formula for eczema has been developed. Based on the causes of this disease, it provides multi-target synergistic treatment, which can meet the needs of patients for low-cost, safe, efficient and less recurring treatment of this disease. It has broad application prospects and promotion value in clinical practice. Summary of the Invention

[0005] In view of the significant side effects and easy recurrence of hormone drugs currently used in clinical practice; the poor permeability and slow efficacy of traditional Chinese medicine ointments; and the high loss rate of effective ingredients due to crude preparation processes, this invention aims to provide a Chinese medicine formula, Chinese medicine preparation and preparation method for treating eczema. It has the advantages of good efficacy, low price, low recurrence rate and no dependence for eczema, dry dermatitis, burns and insect bite dermatitis.

[0006] To achieve the above objectives, the technical solution of the present invention is as follows: The first aspect of this invention discloses a traditional Chinese medicine formula for treating eczema, which comprises the following ingredients in parts by weight: licorice root 30-70 parts, purple gromwell root 30-70 parts, angelica root 30-70 parts, sophora root 10-30 parts, dictamnus root bark 10-30 parts, fleeceflower root vine 5-20 parts, coptis root 3-9 parts, rhubarb 5-10 parts, peppermint 5-20 parts, borneol 5-10 parts, pearl powder 0.5-1.5 parts, and beeswax 300-500 parts.

[0007] As a preferred embodiment of the above technical solution, the traditional Chinese medicine formula includes the following ingredients in parts by weight: licorice 30-50 parts, gromwell root 30-50 parts, angelica root 30-50 parts, sophora root 20-30 parts, dictamnus root bark 20-30 parts, fleeceflower stem 5-10 parts, coptis root 6-9 parts, rhubarb 5-10 parts, peppermint 5-10 parts, borneol 5-10 parts, pearl powder 0.5-1 part, and beeswax 300-400 parts.

[0008] As a preferred embodiment of the above technical solution, the traditional Chinese medicine formula includes the following ingredients in parts by weight: 50 parts licorice, 50 parts gromwell root, 50 parts angelica, 20 parts sophora flavescens, 20 parts dictamnus dasycarpus root bark, 10 parts polygonum multiflorum vine, 6 parts coptis chinensis, 5 parts rhubarb, 10 parts peppermint, 5 parts borneol, 1 part pearl powder, and 400 parts beeswax.

[0009] A second aspect of the present invention discloses a traditional Chinese medicine preparation for treating eczema, which is prepared by mixing the above-mentioned traditional Chinese medicine formula with oil phase components.

[0010] A further preferred option is that the traditional Chinese medicine preparation is any one of the following: ointment, oil, powder, or spray.

[0011] A third aspect of this invention discloses a method for preparing a traditional Chinese medicine ointment for treating eczema, comprising the following steps: Step 1: Weigh out the following ingredients according to the above weight proportions: licorice, purple gromwell, angelica, sophora flavescens, dictamnus dasycarpus root bark, fleeceflower stem, coptis chinensis, rhubarb, peppermint, borneol, pearl powder, and beeswax. Also take the above oil phase components, which include 800-1000mL of sesame oil and 2-5 parts of lard. Set aside. Step 2: Heat the lard from Step 1 over low heat until completely melted. Add sesame oil to the lard and simmer over low heat at 120-150℃ for 20-30 minutes, keeping the oil temperature at 120-150℃. Then add beeswax and dissolve it completely. Step 3: Continue to simmer over low heat, adding licorice, sophora flavescens, dictamnus dasycarpus, scutellaria baicalensis, coptis chinensis, rhubarb, and angelica sinensis in sequence. Fry until the oil foam decreases and the above Chinese medicinal materials turn golden yellow. Use a slotted spoon to remove the dregs and reserve the oil for later use. Step 4: Turn off the heat source, add the purple gromwell root to the oil using the residual heat, fry for about 10-20 seconds until the oil foam decreases, and use a slotted spoon to remove the dregs; Step 5: Continue adding mint to the oil, and after about 10-20 seconds, use a slotted spoon to remove the dregs; Step 6: Continue to add borneol and pearl powder to the oil, stir to dissolve, and pour into a container after the oil temperature drops to 50-75℃. After the paste solidifies, seal and store it away from light.

[0012] The fourth aspect of the present invention discloses the application of the above-mentioned traditional Chinese medicine formula in the preparation of drugs for dry dermatitis, burns, and insect bite dermatitis.

[0013] The following are the properties, flavors, meridian tropisms, and effects of each Chinese herbal medicine and excipient used in the preparation process in this invention: Licorice: Properties: sweet, neutral; Channels entered: heart, lung, spleen, stomach; Functions: tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, relieves spasms and pain, harmonizes other herbs.

[0014] Purple gromwell: Properties: sweet, salty, cold; Channels entered: heart and liver; Functions: cools blood and promotes blood circulation, detoxifies and promotes rash eruption.

[0015] Angelica sinensis: Properties: sweet, pungent, warm; Channels entered: liver, heart, spleen; Functions: nourishes blood and promotes blood circulation, regulates menstruation and relieves pain, moistens the intestines and promotes bowel movement.

[0016] Sophora flavescens: Properties: bitter, cold; Channels entered: heart, liver, stomach, large intestine, bladder; Functions: clears heat and dries dampness, kills parasites, promotes diuresis.

[0017] Dictamnus dasycarpus root bark: Properties: bitter, cold; Channels entered: spleen, stomach, bladder, small intestine; Functions: clears heat and dries dampness, dispels wind and detoxifies.

[0018] Polygonum multiflorum vine: Properties: sweet, neutral; Channels entered: heart and liver; Functions: nourishes blood and calms the mind, dispels wind and unblocks the channels.

[0019] Coptis chinensis: Properties: bitter, cold; Channels entered: heart, spleen, stomach, liver, gallbladder, large intestine; Functions: clears heat and dries dampness, drains fire and detoxifies.

[0020] Rhubarb: Properties: bitter, cold; Channels entered: spleen, stomach, large intestine, liver, pericardium; Functions: purgative, clearing heat and fire, cooling blood and detoxifying, removing blood stasis and promoting menstruation, promoting diuresis and relieving jaundice.

[0021] Peppermint: Properties: pungent, cool; Channels entered: lung and liver; Functions: dispels wind-heat, clears the head and eyes, soothes the throat, promotes rash eruption, and soothes the liver and regulates qi.

[0022] Borneol: Properties: pungent, bitter, slightly cold; Channels entered: heart, spleen, lung; Functions: opens the orifices and refreshes the mind, clears heat and relieves pain.

[0023] Pearl powder: Properties: sweet, salty, cold; Channels entered: heart and liver; Functions: calms the mind and relieves anxiety, improves eyesight and removes corneal opacity, detoxifies and promotes tissue regeneration, moisturizes the skin and removes blemishes.

[0024] Beeswax: Properties: sweet, slightly warm; Channels entered: spleen, stomach, large intestine; Functions: detoxification, wound healing, tissue regeneration, pain relief.

[0025] Sesame oil: Properties: sweet, cool; Channels entered: large intestine, lung; Functions: moisturizes dryness, lubricates the intestines, detoxifies, and promotes tissue regeneration.

[0026] Lard: Properties: sweet, slightly cold; Channels entered: spleen, stomach, large intestine; Functions: tonifies deficiency, moistens dryness, detoxifies.

[0027] The etiology and pathogenesis of eczema: Eczema is generally caused by congenital intolerance, leading to the invasion of wind, dampness, and heat pathogens into the skin. It is often caused by improper diet, excessive consumption of spicy and pungent foods that aggravate wind, or excessive alcohol consumption damaging the spleen and stomach, resulting in impaired spleen function, internal damp-heat generation, and external invasion of wind, dampness, and heat pathogens. These combined pathogens invade the skin; or emotional distress, stagnation of liver qi, impaired qi flow, and internal generation of phlegm and dampness; or inherent spleen deficiency, with the spleen burdened by dampness, leading to water retention and insufficient production of nutrients; or prolonged damp-heat depleting yin and blood, eventually generating wind and dryness, resulting in malnourishment of the skin. Clinically, it is divided into acute, subacute, and chronic phases. The traditional Chinese medicine formula of this invention targets subacute and chronic eczema, clinically manifested as dark red skin lesions or pigmentation, severe itching, or rough and thickened skin lesions. The main pathogenesis is blood deficiency, wind-dryness, and damp-heat. The treatment principle of external therapy is to nourish blood and moisturize the skin, dispel wind and clear heat, and relieve dampness and itching.

[0028] This invention is based on the ancient formula of Runji Ointment from *Surgical Orthodox* and the "Licorice Oil" formula recorded by Professor Zhao Bingnan, a leading figure in modern dermatology, in *Collection of Clinical Experiences by Zhao Bingnan*. The original formula of Runji Ointment included: sesame oil, angelica, purple gromwell root, and beeswax. "Licorice Oil" consists of licorice and sesame oil; it has detoxifying, moisturizing, and wound-cleaning effects. This invention optimizes the ingredients based on the ancient and modern formulas and improves the processing technology to produce a topical ointment, primarily targeting the pathogenesis of blood deficiency, wind-dryness, and damp-heat syndrome.

[0029] Compared with the prior art, the present invention can produce the following beneficial effects: 1. This invention is an optimized version of the ancient formula of "Surgical Orthodox" skin-moistening ointment. It uses purple gromwell and angelica as the principal herbs to cool and nourish the blood, detoxify, and promote rash eruption. Licorice, beeswax, sophora flavescens, and dictamnus dasycarpus are used as assistant herbs to enhance the blood-nourishing and skin-moisturizing effects of the principal herbs, while also clearing heat, promoting diuresis, and detoxifying. Polygonum multiflorum, coptis chinensis, and rhubarb are used as adjuvant herbs to further assist the assistant herbs in clearing heat, promoting diuresis, dispelling wind, and relieving itching. Peppermint, borneol, and pearl powder are used as guiding herbs to enhance transdermal absorption, allowing the medicinal properties of the above-mentioned Chinese herbal ingredients to reach the affected area more effectively. Simultaneously, pearl powder has detoxifying, tissue-regenerating, skin-moisturizing, and blemish-removing effects, alleviating the thickening, roughness, and dullness of the skin after prolonged scratching of subacute and chronic eczema. Sesame oil and lard, although excipients, also have moisturizing, detoxifying, and tissue-regenerating effects. After improvement, the synergistic effect of multiple targets can be achieved to nourish blood and moisturize the skin, dispel wind and clear heat, and relieve dampness and itching. It has the advantages of good efficacy, low recurrence rate and no dependence in the treatment of eczema.

[0030] 2. This invention improves the preparation process by using staged frying of medicinal materials (frying time of Lithospermum erythrorhizon ≤20 seconds to prevent degradation of Lithospermum erythrorhizon), while ensuring the addition of volatile components (menthol and borneol, with borneol added at a temperature ≤75°C to avoid volatilization loss) under low-temperature conditions. This maximizes the preservation of the activity of volatile components, ensures the transdermal penetration of the ointment, and improves the extraction efficiency and stability of the active ingredients. At the same time, the composite matrix of beeswax and sesame oil enhances the transdermal properties and stability of the ointment.

[0031] 3. The traditional Chinese medicine ointment of this invention has a low cost, with raw material costs only 1 / 5 of those of imported Western medicines, making it suitable for industrial production. Clinical case verification shows that it is made of pure traditional Chinese medicine ingredients, has no side effects such as skin atrophy and pigmentation, has no hormone dependence, and is highly safe. Attached Figure Description

[0032] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0033] Figure 1 The images show actual pictures of all the Chinese herbal ingredients in a traditional Chinese medicine formula for treating eczema according to the present invention. Figure 2 The diagram shows the frying process of this invention, in which licorice, sophora flavescens, and dictamnus dasycarpus are added to an oil pan in sequence. Figure 3 The diagram shows the process of frying Polygonum multiflorum vine, Coptis chinensis and Angelica sinensis in oil in sequence during the preparation of this invention. Figure 4 A diagram showing the frying process of adding Lithospermum erythrorhizon to an oil pan to illustrate the preparation process of this invention. Figure 5 The diagram illustrates the process of adding mint to the oil pan in the preparation process of this invention. Figure 6 A diagram illustrating the process of adding borneol to an oil pan in the preparation of this invention. Figure 7 The diagram illustrates the process of adding pearl powder to an oil pan in the preparation of this invention. Figure 8 The image shows the medicinal juice after all the Chinese medicinal materials have been removed, which is the preparation process of this invention. Figure 9 A filling diagram illustrating the preparation process of this invention; Figure 10 Two figures illustrating the filling process of the present invention; Figure 11 This is a finished product image of the traditional Chinese medicine preparation of the present invention; Figure 12 A before-and-after comparison of clinical patient 1 using the traditional Chinese medicine preparation of this invention; Figure 13 A before-and-after comparison of clinical patient 2 treated with the traditional Chinese medicine preparation of this invention; Figure 14 Before and after treatment of three clinical patients using the traditional Chinese medicine preparation of this invention; Figure 15 Before and after treatment of clinical patient 4 using the traditional Chinese medicine preparation of this invention; Figure 16 Before and after treatment of 5 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 17 Before and after treatment of 6 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 18 Before and after treatment of 7 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 19 Before and after treatment of 8 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 20 Before and after treatment of 9 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 21 Before and after treatment of 10 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 22 Before and after treatment of 11 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 23 Before and after treatment of 12 clinical patients using the traditional Chinese medicine preparation of this invention; Figure 24 The image shows a before-and-after comparison of clinical patients 13 who used the traditional Chinese medicine preparation of this invention. Detailed Implementation

[0034] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some embodiments of the present invention, but not all embodiments.

[0035] Reference Figures 1-11 This invention provides a traditional Chinese medicine formula, a traditional Chinese medicine preparation, and a method for preparing the same for treating eczema, wherein: The present invention provides a traditional Chinese medicine formula for treating eczema, comprising the following ingredients in parts by weight: licorice root 30-70 parts, purple gromwell root 30-70 parts, angelica root 30-70 parts, sophora root 10-30 parts, dictamnus root bark 10-30 parts, fleeceflower root vine 5-20 parts, coptis root 3-9 parts, rhubarb 5-10 parts, peppermint 5-20 parts, borneol 5-10 parts, pearl powder 0.5-1.5 parts, and beeswax 300-500 parts.

[0036] Preferably, the traditional Chinese medicine formula includes the following ingredients in parts by weight: licorice 30-50 parts, gromwell root 30-50 parts, angelica root 30-50 parts, sophora root 20-3 parts, dictamnus root bark 20-30 parts, fleeceflower stem 5-10 parts, coptis root 6-9 parts, rhubarb 5-10 parts, peppermint 5-10 parts, borneol 5-10 parts, pearl powder 0.5-1 part, and beeswax 300-400 parts.

[0037] Preferably, the traditional Chinese medicine formula includes the following ingredients in parts by weight: 50 parts licorice, 50 parts gromwell root, 50 parts angelica, 20 parts sophora flavescens, 20 parts dictamnus dasycarpus root bark, 10 parts fleeceflower root vine, 6 parts coptis, 5 parts rhubarb, 10 parts peppermint, 5 parts borneol, 1 part pearl powder, and 400 parts beeswax.

[0038] The present invention provides a traditional Chinese medicine preparation for treating eczema, which is prepared by mixing the above-mentioned traditional Chinese medicine formula with oil phase components. The traditional Chinese medicine preparation is any one of ointment, oil, powder, or spray, and is preferably an ointment for easy application.

[0039] This invention discloses a method for preparing a traditional Chinese medicine ointment for treating eczema. Following an improved preparation process—matrix pretreatment—staged extraction of medicinal materials—low-temperature addition of volatile components—forming and preservation—this method enhances the extraction efficiency and stability of the active ingredients while extending the shelf life of the ointment. Specifically, it includes the following steps: Step 1: Weigh out the following ingredients according to the above weight proportions: licorice, purple gromwell, angelica, sophora flavescens, dictamnus dasycarpus root bark, fleeceflower stem, coptis chinensis, rhubarb, peppermint, borneol, pearl powder, and beeswax. Also take the above oil phase components, which include 800-1000mL of sesame oil and 2-5 parts of lard. Set aside. Step 2: Heat the lard from Step 1 over low heat until completely melted. Add sesame oil to the lard and simmer over low heat at 120-150℃ for 20-30 minutes, keeping the oil temperature at 120-150℃. Then add beeswax and dissolve it completely. Step 3: Continue to simmer over low heat, adding licorice, sophora flavescens, dictamnus dasycarpus, scutellaria baicalensis, coptis chinensis, rhubarb, and angelica sinensis in sequence. Fry until the oil foam decreases and the above Chinese medicinal materials turn golden yellow. Use a slotted spoon to remove the dregs and reserve the oil for later use. Step 4: Turn off the heat source, add the purple gromwell root to the oil using the residual heat, fry for about 10-20 seconds until the oil foam decreases, and use a slotted spoon to remove the dregs; Step 5: Continue adding mint to the oil, and after about 10-20 seconds, use a slotted spoon to remove the dregs; Step 6: Continue to add borneol and pearl powder to the oil, stir to dissolve, and pour into a container after the oil temperature drops to 50-75℃. After the paste solidifies, seal and store it away from light.

[0040] Example 1: Weigh out 50 parts by weight of licorice, 50 parts of gromwell root, 50 parts of angelica, 20 parts of sophora flavescens, 20 parts of dictamnus dasycarpus root bark, 10 parts of fleeceflower root vine, 6 parts of coptis chinensis, 5 parts of rhubarb, 10 parts of peppermint, 5 parts of borneol, 1 part of pearl powder, and 400 parts of beeswax. Prepare the ointment according to the above-mentioned process, adding 800 mL of sesame oil and 2 parts of lard during the preparation. After making the ointment, seal and store it away from light.

[0041] Example 2: Weigh out 50 parts by weight of licorice, 50 parts of gromwell root, 50 parts of angelica, 30 parts of sophora flavescens, 30 parts of dictamnus dasycarpus root bark, 10 parts of fleeceflower root vine, 9 parts of coptis chinensis, 10 parts of rhubarb, 10 parts of peppermint, 10 parts of borneol, 1 part of pearl powder, and 500 parts of beeswax. Prepare the ointment according to the above-mentioned process, adding 1000 mL of sesame oil and 5 parts of lard during the preparation process. After making the ointment, seal and store it away from light.

[0042] Example 3: Weigh out 50 parts by weight of licorice, 50 parts of gromwell root, 50 parts of angelica root, 10 parts of sophora root, 10 parts of dictamnus root bark, 5 parts of fleeceflower stem, 6 parts of coptis root, 5 parts of rhubarb, 5 parts of peppermint, 5 parts of borneol, 0.5 parts of pearl powder, and 300 parts of beeswax. Prepare the ointment according to the above process, adding 1000 mL of sesame oil and 3 parts of lard. After preparation, seal and store in a dark place.

[0043] Example 4: Weigh out 40 parts by weight of licorice, 40 parts of gromwell root, 40 parts of angelica, 20 parts of sophora flavescens, 20 parts of dictamnus dasycarpus root bark, 5 parts of fleeceflower root vine, 8 parts of coptis chinensis, 10 parts of rhubarb, 10 parts of peppermint, 10 parts of borneol, 1 part of pearl powder, and 400 parts of beeswax. Prepare the ointment according to the above-mentioned process, adding 800 mL of sesame oil and 4 parts of lard during the preparation process. After making the ointment, seal and store it away from light.

[0044] Example 5: Take 30 parts by weight of licorice root, 30 parts of purple gromwell root, 30 parts of angelica root, 30 parts of sophora root, 30 parts of dictamnus root bark, 10 parts of fleeceflower stem, 9 parts of coptis root, 10 parts of rhubarb, 10 parts of peppermint, 10 parts of borneol, 0.5 parts of pearl powder, and 300 parts of beeswax. Prepare the ointment according to the above process, adding 800 mL of sesame oil and 3 parts of lard. After making the ointment, seal and store it away from light.

[0045] Example 6: Take 30 parts by weight of licorice, 30 parts of gromwell root, 30 parts of angelica, 10 parts of sophora flavescens, 10 parts of dictamnus dasycarpus root bark, 5 parts of fleeceflower root vine, 6 parts of coptis chinensis, 5 parts of rhubarb, 5 parts of peppermint, 5 parts of borneol, 0.5 parts of pearl powder, and 300 parts of beeswax. Prepare the ointment according to the above process, adding 800 mL of sesame oil and 3 parts of lard. After making the ointment, seal and store it away from light.

[0046] Example 7: Take 70 parts by weight of licorice, 70 parts of gromwell root, 70 parts of angelica, 30 parts of sophora flavescens, 30 parts of dictamnus dasycarpus root bark, 20 parts of fleeceflower root vine, 9 parts of coptis chinensis, 10 parts of rhubarb, 20 parts of peppermint, 10 parts of borneol, 1.5 parts of pearl powder, and 500 parts of beeswax. Prepare the ointment according to the above process, adding 1000 mL of sesame oil and 5 parts of lard. After making the ointment, seal and store it away from light.

[0047] Example 8: Take 70 parts by weight of licorice, 70 parts of gromwell root, 70 parts of angelica, 10 parts of sophora flavescens, 10 parts of dictamnus dasycarpus root bark, 10 parts of polygonum multiflorum vine, 6 parts of coptis chinensis, 5 parts of rhubarb, 5 parts of peppermint, 5 parts of borneol, 1 part of pearl powder, and 300 parts of beeswax. Prepare the ointment according to the above process, adding 1000 mL of sesame oil and 5 parts of lard. After making the ointment, seal and store it away from light.

[0048] The following Chinese medicinal materials are prepared according to the above preparation process: 30-70 parts of licorice, 30-70 parts of gromwell root, 30-70 parts of angelica, 10-30 parts of sophora flavescens, 10-30 parts of dictamnus dasycarpus root bark, 5-20 parts of fleeceflower stem, 3-9 parts of coptis chinensis, 5-10 parts of rhubarb, 5-20 parts of peppermint, 5-10 parts of borneol, 0.5-1.5 parts of pearl powder, and 300-500 parts of beeswax. 900 mL of sesame oil and 4 parts of lard are added during the preparation process. After the ointment is made, it is sealed and stored away from light.

[0049] Clinical application cases: Case 1: Li XX, female, 74 years old, with recurrent dark red papules and nodules and pigmentation on both lower limbs for 2 years.

[0050] The patient presented in June 2024 with a history of diabetes and hypertension, which they reported were well-controlled. Examinations at the time of consultation showed normal blood routine and liver and kidney function. The diagnosis was eczema. Due to multiple underlying conditions requiring various medications, the patient expressed concern about oral eczema treatments. They were treated with the herbal ointment described in Example 1 of this invention, applied twice daily. After three weeks of treatment, the condition improved; most nodules flattened, and the original small papules subsided. The patient was instructed to use a moisturizing cream daily. Currently, during follow-up, occasional small flare-ups occur. The patient refuses oral medications and intermittently uses the herbal ointment described in Example 1 of this invention. Comparison before and after treatment is provided. Figure 12 As shown.

[0051] Case 2: Xie XX, female, 24 years old, with recurrent erythematous scaling and itching in both popliteal fossae for 2 years.

[0052] The patient's condition had been recurring for the past two years. Topical application of halometasone cream and 999 dermatitis cream provided temporary relief, reducing itching, but the condition returned after discontinuation. Concerned about the long-term side effects of topical corticosteroids, the patient consulted a doctor in September 2024. Previously healthy, examinations at the time of consultation included: complete blood count, liver function, kidney function, three infectious disease markers, and hepatitis B surface antigen and antibody tests, all normal. The diagnosis was eczema. Treatment involved topical application of the herbal ointment described in Example 1 of this invention, twice daily. After three weeks of treatment, the erythema and scaling in both popliteal fossae significantly improved. The patient was instructed to continue topical application without concern about the risks of skin atrophy associated with corticosteroids. Due to a change in work, the patient did not return for follow-up visits. Before and after treatment comparisons are provided. Figure 13 As shown.

[0053] Case 3: Tang XX, female, 30 years old, presented with pigmentation on both lower extremities for 1 year and itchy papules and nodules for 2 weeks. She consulted in December 2024. She had a history of breast nodules and thyroid nodules. A physical examination report in November 2024 showed no abnormalities in blood routine, liver function, kidney function, or hepatitis B surface antigen and antibody. She was diagnosed with eczema. The patient planned to conceive and refused topical corticosteroid ointments and oral medications. She was treated with the traditional Chinese medicine ointment described in Example 1 of this invention, applied twice daily. After 4 weeks of treatment, the papules and nodules subsided, leaving only pigmentation. Follow-up to date shows no recurrence. Comparison before and after treatment is shown. Figure 14 As shown.

[0054] Case 4: Yan XX, female, 23 years old, with dark red, scaly, and itchy patches in both elbow creases for 1 year.

[0055] The patient sought medical attention in August 2024. Her condition worsened during the winter. She had previously used various moisturizing creams and ointments (details unknown), but the condition continued to recur, and she was concerned about the side effects of topical Western medicines. She had no prior medical history. The diagnosis was eczema. She was treated with the traditional Chinese medicine ointment described in Example 1 of this invention, applied twice daily. After four weeks of treatment, the original erythema and scaling subsided, leaving pigmentation. Follow-up revealed occasional relapses after consuming spicy foods, but the rest of her condition remained generally stable. Comparison before and after treatment is shown. Figure 15 As shown.

[0056] Case 5: Chen XX, male, 68 years old, with dark red spots, rough, thickened and itchy skin on his neck and back for 1 year.

[0057] The patient sought medical attention in May 2024, with symptoms worsening after sun exposure. They had a history of coronary heart disease, hypertension, and diabetes, and were taking related internal medicine medications daily, the specific control details of which were unclear. The diagnosis was eczema. Knowing they had multiple medical conditions, the patient temporarily refused oral medications. The traditional Chinese medicine ointment described in Example 1 of this invention was applied topically 2-3 times daily for 8 weeks. After treatment, the patient was advised to pay attention to sun protection and maintain a light diet. Following treatment, the previously rough and thickened skin thinned, leaving residual pigmentation. The patient later left the area for family reasons and was not followed up. Comparison before and after treatment is not available. Figure 16 As shown.

[0058] Case 6: Li X, male, 51 years old, with dark red, scaly, and itchy patches on his back for half a year.

[0059] The patient presented in August 2024, with no prior medical history. Examinations included routine blood tests, liver and kidney function tests, electrolyte tests, infection panel, and hepatitis B surface antigen and antibody tests, all of which were normal. The diagnosis was eczema. Treatment involved topical application of the herbal ointment described in Example 1 of this invention, 2-3 times daily. After 6 weeks of treatment, the original erythema darkened, leaving residual pigmentation. Follow-up revealed occasional relapses due to dietary indiscretion. After dietary control and continued topical application of the herbal ointment described in Example 1 of this invention, the rash subsided. Comparison before and after treatment was provided. Figure 17 As shown.

[0060] Case 7: Huang X, male, 58 years old, with recurrent erythematous papules and itching on both upper limbs for 5 years.

[0061] The patient presented in October 2024. Previous use of various topical disinfectant products (details unknown) had slightly controlled the condition, but it recurred after discontinuation. The patient had no prior medical history and denied any drug or food allergies. The diagnosis was eczema. Medication education was provided, and the use of disinfectant products was advised to be avoided as much as possible. The patient was treated with the traditional Chinese medicine ointment described in Example 1 of this invention, applied 2-3 times daily. After 6 weeks of treatment, itching improved. The original erythema darkened, leaving residual pigmentation. Comparison before and after treatment is shown. Figure 18 As shown.

[0062] Case 8: Sun XX, male, 59 years old, with recurrent itchy erythematous papules on his back for 3 years.

[0063] The patient presented in March 2023, with symptoms worsening in cold weather and a preference for washing the affected area with hot water. The patient had no prior medical history and denied any drug or food allergies. The diagnosis was eczema. Warm water baths were recommended. In winter, a moisturizing cream was used in conjunction with topical application of the traditional Chinese medicine ointment described in Example 1 of this invention, 2-3 times daily. After 6 weeks of treatment, itching improved. The original erythema darkened, leaving residual pigmentation. The before-and-after comparison is shown. Figure 19 As shown.

[0064] Case 9: Li XX, male, 24 years old, with recurrent erythema, desquamation and itching on both hands for 2 years.

[0065] The patient visited the clinic in May 2024, with no prior medical history. The diagnosis was eczema. The patient refused oral medications and topical steroid creams, and instead received topical treatment with the traditional Chinese medicine ointment described in Example 1 of this invention, twice daily. After three weeks of treatment, the condition improved; erythema subsided, desquamation improved, and itching lessened. Comparison before and after treatment is shown. Figure 20 As shown.

[0066] Case 10: Liang XX, male, 44 years old, with erythema, desquamation and itching on both hands for 1 month.

[0067] The patient visited a clinic in March 2024, with no prior medical history. The diagnosis was eczema. Treatment involved the topical application of the herbal ointment described in Example 1 of this invention, twice daily. After two weeks of treatment, the condition improved; erythema subsided, desquamation improved, and itching lessened. Comparison before and after treatment is shown. Figure 21 As shown.

[0068] Case 11: Zhang XX, male, 42 years old, with dark red pigmentation and itching on his back for 2 months.

[0069] The patient visited the clinic in November 2024, reporting a history of high stress but previously good health. The diagnosis was eczema. Emotional education and counseling were provided. The patient refused topical corticosteroid ointments and was instead treated with the traditional Chinese medicine ointment described in Example 1 of this invention, applied twice daily. After three weeks of treatment, the condition improved, the dark red patches faded, and itching lessened. Comparison before and after treatment is shown. Figure 22 As shown.

[0070] Case 12: Li XX, male, 40 years old, with recurrent erythema and itching on both lower limbs for 3 months.

[0071] The patient visited the clinic in May 2024, with no prior medical history. The diagnosis was eczema. The patient refused topical corticosteroid ointments and instead received topical treatment with the traditional Chinese medicine ointment described in Example 1 of this invention, twice daily. After two weeks of treatment, the condition improved, erythema subsided, residual pigmentation was observed, and itching decreased. Comparison before and after treatment is shown. Figure 23 As shown.

[0072] Case 13: Wu XX, male, 59 years old, with recurrent peeling, erythema and itching on both hands for 3 years.

[0073] The patient visited the clinic in March 2024, with no prior history of illness. The condition worsened in winter, and various topical moisturizing creams had been ineffective. The diagnosis was eczema. The traditional Chinese medicine ointment described in Example 1 of this invention was applied topically twice daily. After two weeks of treatment, the condition significantly improved, with reduced skin scaling and itching. The before-and-after comparison is shown below. Figure 24 As shown.

[0074] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine formula for treating eczema, characterized in that, This traditional Chinese medicine formula includes the following ingredients in parts by weight: licorice root 30-70 parts, gromwell root 30-70 parts, angelica root 30-70 parts, sophora root 10-30 parts, dictamnus root bark 10-30 parts, fleeceflower root vine 5-20 parts, coptis root 3-9 parts, rhubarb 5-10 parts, peppermint 5-20 parts, borneol 5-10 parts, pearl powder 0.5-1.5 parts, and beeswax 300-500 parts.

2. The traditional Chinese medicine formula for treating eczema according to claim 1, characterized in that, This traditional Chinese medicine formula includes the following ingredients in parts by weight: licorice root 30-50 parts, purple gromwell root 30-50 parts, angelica root 30-50 parts, sophora root 20-30 parts, dictamnus root bark 20-30 parts, fleeceflower root vine 5-10 parts, coptis root 6-9 parts, rhubarb 5-10 parts, peppermint 5-10 parts, borneol 5-10 parts, pearl powder 0.5-1 part, and beeswax 300-400 parts.

3. The traditional Chinese medicine formula for treating eczema according to claim 1, characterized in that, This traditional Chinese medicine formula includes the following ingredients by weight: 50 parts licorice, 50 parts gromwell root, 50 parts angelica root, 20 parts sophora root, 20 parts dictamnus root bark, 10 parts fleeceflower stem, 6 parts coptis root, 5 parts rhubarb, 10 parts peppermint, 5 parts borneol, 1 part pearl powder, and 400 parts beeswax.

4. A traditional Chinese medicine preparation for treating eczema, characterized in that, This traditional Chinese medicine preparation is prepared by mixing the traditional Chinese medicine formula according to any one of claims 1-3 with the oil phase components.

5. A traditional Chinese medicine preparation for treating eczema according to claim 4, characterized in that, The traditional Chinese medicine preparation can be any one of the following: ointment, oil, powder, or spray.

6. The method for preparing a traditional Chinese medicine ointment for treating eczema according to claim 5, characterized in that, Includes the following steps: Step 1: Weigh out the following ingredients according to the weight proportions in claim 1: licorice, purple gromwell, angelica, sophora flavescens, dictamnus dasycarpus root bark, fleeceflower stem, coptis chinensis, rhubarb, peppermint, borneol, pearl powder, and beeswax. Then take the oil phase components from claim 4, which include 800-1000 mL of sesame oil and 2-5 parts of lard. Set aside. Step 2: Heat the lard from Step 1 over low heat until completely melted. Add sesame oil to the lard and simmer over low heat at 120-150℃ for 20-30 minutes, keeping the oil temperature at 120-150℃. Then add beeswax and dissolve it completely. Step 3: Continue to simmer over low heat, adding licorice, sophora flavescens, dictamnus dasycarpus, scutellaria baicalensis, coptis chinensis, rhubarb, and angelica sinensis in sequence. Fry until the oil foam decreases and the above Chinese medicinal materials turn golden yellow. Use a slotted spoon to remove the dregs and reserve the oil for later use. Step 4: Turn off the heat source, add the purple gromwell root to the oil using the residual heat, fry for about 10-20 seconds until the oil foam decreases, and use a slotted spoon to remove the dregs; Step 5: Continue adding mint to the oil, and after about 10-20 seconds, use a slotted spoon to remove the dregs; Step 6: Continue to add borneol and pearl powder to the oil, stir to dissolve, and pour into a container after the oil temperature drops to 50-75℃. After the paste solidifies, seal and store it away from light.

7. The application of the traditional Chinese medicine formula according to any one of claims 1-3 in the preparation of drugs for dry dermatitis, burns, and insect bite dermatitis.

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