Traditional Chinese medicine preparation for treating chronic pancreatitis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation for treating chronic pancreatitis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following components in parts by weight: 5-15 parts of codonopsis pilosula, 10-20 parts of herba patriniae, 5-15 parts of radix bupleuri, 4-8 parts of solanum lyratum thunb, 5-15 parts of scutellaria baicalensis, 5-15 parts of trogopterus dung, 5-15 parts of immature bitter orange, 5-10 parts of szechwan chinaberry fruit, 10-20 parts of poria cocos, 4-6 parts of polygonum cuspidatum, 10-20 parts of radix paeoniae alba, 10-20 parts of curcuma zedoary, 4-8 parts of liquorice, 10-15 parts of radix asparagi, 4-8 parts of rheum officinale and 10-15 According to the theory of traditional Chinese medicine, Chinese herbal medicines with the effects of invigorating spleen and replenishing qi, promoting blood circulation to remove blood stasis, soothing liver and clearing heat, removing blood stasis and relieving pain, promoting qi circulation and relieving pain and the like are screened and combined, the symptoms of chronic pancreatitis can be rapidly improved, the effect is remarkable, and toxic and side effects are avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating chronic pancreatitis and a preparation method thereof. BACKGROUND

[0002] Chronic pancreatitis (CP) is a multifactorial fibro-inflammatory syndrome in which repeated episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting in chronic pain, exocrine and endocrine insufficiency of the pancreas.

[0003] The commonly used western medicines for treating chronic pancreatitis in the clinic at present mainly include Tongbao capsules, Aspergillus oryzae pancreatin tablets and compound achimite enteric-coated capsules, which have great side effects and are prone to recurrence.

[0004] Therefore, the present application is proposed. SUMMARY

[0005] The present application aims to provide a traditional Chinese medicine preparation for treating chronic pancreatitis and a preparation method thereof.

[0006] In order to achieve the above-mentioned purpose of the present application, the following technical scheme is adopted:

[0007] The present application provides a traditional Chinese medicine preparation for treating chronic pancreatitis in the first aspect, which is prepared from the following components by weight:

[0008] Dangshen 5-15 parts, Baijiangcao 10-20 parts, Chaihu 5-15 parts, Baomaoteng 4-8 parts, Huangqi 5-15 parts, Wulingzhi 5-15 parts, Zhishi 5-15 parts, Chuanlianzi 5-10 parts, Fuling 10-20 parts, Hujiang 4-6 parts, Baishao 10-20 parts, E'zhu 10-20 parts, Gancao 4-8 parts, Tianmen Dong 10-15 parts, Dahuang 4-8 parts and Baizhu 10-15 parts.

[0009] Preferably, the traditional Chinese medicine preparation is prepared from the following components by weight:

[0010] Dangshen 8-12 parts, Baijiangcao 12-18 parts, Chaihu 8-12 parts, Baomaoteng 5-7 parts, Huangqi 8-12 parts, Wulingzhi 8-12 parts, Zhishi 8-12 parts, Chuanlianzi 6-8 parts, Fuling 12-18 parts, Hujiang 5-6 parts, Baishao 12-18 parts, E'zhu 12-18 parts, Gancao 5-7 parts, Tianmen Dong 12-13 parts, Dahuang 5-7 parts and Baizhu 12-13 parts.

[0011] Preferably, the traditional Chinese medicine preparation is prepared from the following components by weight:

[0012] Dangshen 10 parts, Baijiangcao 15 parts, Chaihu 10 parts, Baimaoceng 6 parts, Huangqi 10 parts, Wulingzhi 10 parts, Zhishi 10 parts, Chuanlianzi 7 parts, Fuling 15 parts, Hujiang 6 parts, Baishao 15 parts, Ezhu 15 parts, Gancao 6 parts, Tianmen Dong 12 parts, Dahuang 6 parts and Baizhu 12 parts.

[0013] The second aspect of the present application provides a preparation method of the above-mentioned traditional Chinese medicine preparation, which comprises the following steps:

[0014] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0015] (b) adding each traditional Chinese medicine component into water to decoct, filtering, adding water into the filter residue to continue decocting, filtering, and combining the filtrates, to obtain the traditional Chinese medicine preparation.

[0016] Preferably, the decocting comprises boiling with strong fire and decocting with weak fire for 1-2 hours.

[0017] Preferably, the mass ratio of the traditional Chinese medicine component to water is 1:(6-10).

[0018] Preferably, the amount of water added into the filter residue is 5-8 times of the mass of the traditional Chinese medicine component.

[0019] Compared with the prior art, the present application has at least the following beneficial effects:

[0020] According to the theory of traditional Chinese medicine, the present inventors screened Chinese herbal medicines with the effects of invigorating the spleen and replenishing qi, promoting blood circulation to remove blood stasis, soothing the liver and clearing heat, removing blood stasis to stop pain, and promoting qi to stop pain, etc. The combined use of the Chinese herbal medicines can quickly improve the symptoms of chronic pancreatitis, has a significant effect, and has no toxic and side effects. DETAILED DESCRIPTION

[0021] The embodiments of the technical solutions of the present application will be described in detail below with reference to the examples. The following examples are only used to more clearly illustrate the technical solutions of the present application, and therefore only serve as examples, but cannot limit the protection scope of the present application.

[0022] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in the present application should be understood as the usual meanings understood by the skilled person in the field to which the present application belongs.

[0023] Example 1

[0024] The present example is a traditional Chinese medicine preparation for treating chronic pancreatitis, which is prepared from the following components by weight parts:

[0025] Radix Codonopsis 5 parts, Patrinia 20 parts, Radix Bupleuri 5 parts, Radix Ampelopsis 8 parts, Radix Scutellariae 15 parts, Myrrh 5 parts, Fructus Aurantii Immaturus 5 parts, Fructus Meliae Toosendan 10 parts, Poria 10 parts, Polygonum Cuspidatum 4 parts, Radix Paeoniae Alba 20 parts, Curcuma 20 parts, Radix Glycyrrhizae 4 parts, Radix Asparagi 15 parts, Rhizoma et Radix Rhei 4 parts, and Rhizoma Atractylodis Macrocephalae 10 parts.

[0026] The preparation method of the above-mentioned traditional Chinese medicine preparation comprises the following steps:

[0027] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0028] (b) adding each traditional Chinese medicine component to water according to the mass ratio of the traditional Chinese medicine component to water being 1:6 to perform decocting and filtering, then adding water with a mass of 5 times that of the traditional Chinese medicine component to the filter residue to continue decocting and filtering, and combining the filtrates to obtain the traditional Chinese medicine preparation, wherein the decocting comprises boiling with strong fire and decocting with weak fire for 1 h.

[0029] Example 2

[0030] The present embodiment is a traditional Chinese medicine preparation for treating chronic pancreatitis, which is prepared from components comprising the following weight parts:

[0031] Radix Codonopsis 15 parts, Patrinia 10 parts, Radix Bupleuri 15 parts, Radix Ampelopsis 4 parts, Radix Scutellariae 5 parts, Myrrh 15 parts, Fructus Aurantii Immaturus 15 parts, Fructus Meliae Toosendan 5 parts, Poria 20 parts, Polygonum Cuspidatum 6 parts, Radix Paeoniae Alba 10 parts, Curcuma 10 parts, Radix Glycyrrhizae 8 parts, Radix Asparagi 10 parts, Rhizoma et Radix Rhei 8 parts, and Rhizoma Atractylodis Macrocephalae 15 parts.

[0032] The preparation method of the above-mentioned traditional Chinese medicine preparation comprises the following steps:

[0033] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0034] (b) adding each traditional Chinese medicine component to water according to the mass ratio of the traditional Chinese medicine component to water being 1:10 to perform decocting and filtering, then adding water with a mass of 8 times that of the traditional Chinese medicine component to the filter residue to continue decocting and filtering, and combining the filtrates to obtain the traditional Chinese medicine preparation, wherein the decocting comprises boiling with strong fire and decocting with weak fire for 2 h.

[0035] Example 3

[0036] The present embodiment is a traditional Chinese medicine preparation for treating chronic pancreatitis, which is prepared from components comprising the following weight parts:

[0037] Radix Codonopsis 8 parts, Patrinia 18 parts, Radix Bupleuri 12 parts, Radix Ampelopsis 7 parts, Radix Scutellariae 8 parts, Myrrh 8 parts, Fructus Aurantii Immaturus 8 parts, Fructus Meliae Toosendan 6 parts, Poria 18 parts, Polygonum Cuspidatum 5 parts, Radix Paeoniae Alba 18 parts, Curcuma 12 parts, Radix Glycyrrhizae 5 parts, Radix Asparagi 12 parts, Rhizoma et Radix Rhei 7 parts, and Rhizoma Atractylodis Macrocephalae 13 parts.

[0038] The preparation method of the traditional Chinese medicine preparation comprises the following steps:

[0039] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0040] (b) adding each traditional Chinese medicine component to water to perform decocting and filtering according to the mass ratio of the traditional Chinese medicine component to water being 1:8, then adding water with a mass of 6 times that of the traditional Chinese medicine component to the filter residue to continue decocting and filtering, and combining the filtrates to obtain the traditional Chinese medicine preparation, wherein the decocting comprises boiling with strong fire and decocting with weak fire for 1.5 h.

[0041] Example 4

[0042] The traditional Chinese medicine preparation for treating chronic pancreatitis is prepared from the following components with the weight parts:

[0043] Dangshen 12 parts, Baijiaocao 12 parts, Chaihu 8 parts, Baimaoteng 5 parts, Huangqi 12 parts, Wulingzhi 12 parts, Zhishi 12 parts, Chuanlianzi 8 parts, Fuling 12 parts, Hujiang 6 parts, Baishao 12 parts, Ezhu 18 parts, Gancao 7 parts, Tianmen Dong 13 parts, Dahuang 5 parts and Baizhu 12 parts.

[0044] The preparation method of the traditional Chinese medicine preparation comprises the following steps:

[0045] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0046] (b) adding each traditional Chinese medicine component to water to perform decocting and filtering according to the mass ratio of the traditional Chinese medicine component to water being 1:8, then adding water with a mass of 6 times that of the traditional Chinese medicine component to the filter residue to continue decocting and filtering, and combining the filtrates to obtain the traditional Chinese medicine preparation, wherein the decocting comprises boiling with strong fire and decocting with weak fire for 1.5 h.

[0047] Example 5

[0048] The traditional Chinese medicine preparation for treating chronic pancreatitis is prepared from the following components with the weight parts:

[0049] Dangshen 10 parts, Baijiaocao 15 parts, Chaihu 10 parts, Baimaoteng 6 parts, Huangqi 10 parts, Wulingzhi 10 parts, Zhishi 10 parts, Chuanlianzi 7 parts, Fuling 15 parts, Hujiang 6 parts, Baishao 15 parts, Ezhu 15 parts, Gancao 6 parts, Tianmen Dong 12 parts, Dahuang 6 parts and Baizhu 12 parts.

[0050] The preparation method of the traditional Chinese medicine preparation comprises the following steps:

[0051] (a) weighing each traditional Chinese medicine component according to the weight parts;

[0052] (b) each of the Chinese medicine components is added to water for decocting and filtering according to a mass ratio of the Chinese medicine component to water of 1:8, 6 times the mass of the Chinese medicine component of water is added to the residue for further decocting and filtering, and the filtrates are combined, to obtain the Chinese medicine preparation, wherein the decocting comprises boiling with a strong fire and decocting with a weak fire for 1.5 h.

[0053] Comparative Example 1

[0054] The present comparative example is a Chinese medicine preparation for treating chronic pancreatitis, which is prepared from components comprising the following weight parts:

[0055] Radix Codonopsis 10 parts, Bupleurum 10 parts, Caulis Ampelopsis 21 parts, Radix Scutellariae 10 parts, Myrrh 10 parts, Fructus Aurantii Immaturus 10 parts, Fructus Xanthoceras 7 parts, Poria 15 parts, Giant Knotweed 6 parts, Radix Paeoniae Alba 15 parts, Curcuma 15 parts, Radix Glycyrrhizae 6 parts, Radix Asparagi 12 parts, Rhubarb 6 parts, and Rhizoma Atractylodis Macrocephalae 12 parts.

[0056] The preparation method of the above Chinese medicine preparation comprises the following steps:

[0057] (a) each of the Chinese medicine components is weighed according to the weight parts;

[0058] (b) each of the Chinese medicine components is added to water for decocting and filtering according to a mass ratio of the Chinese medicine component to water of 1:8, 6 times the mass of the Chinese medicine component of water is added to the residue for further decocting and filtering, and the filtrates are combined, to obtain the Chinese medicine preparation, wherein the decocting comprises boiling with a strong fire and decocting with a weak fire for 1.5 h.

[0059] Comparative Example 2

[0060] The present comparative example is a Chinese medicine preparation for treating chronic pancreatitis, which is prepared from components comprising the following weight parts:

[0061] Radix Codonopsis 10 parts, Bupleurum 10 parts, Caulis Ampelopsis 21 parts, Radix Scutellariae 10 parts, Myrrh 10 parts, Fructus Aurantii Immaturus 10 parts, Fructus Xanthoceras 7 parts, Poria 15 parts, Giant Knotweed 6 parts, Radix Paeoniae Alba 15 parts, Curcuma 15 parts, Radix Glycyrrhizae 6 parts, Radix Asparagi 12 parts, Rhubarb 6 parts, and Rhizoma Atractylodis Macrocephalae 12 parts.

[0062] The preparation method of the above Chinese medicine preparation comprises the following steps:

[0063] (a) each of the Chinese medicine components is weighed according to the weight parts;

[0064] (b) each of the Chinese medicine components is added to water for decocting and filtering according to a mass ratio of the Chinese medicine component to water of 1:8, 6 times the mass of the Chinese medicine component of water is added to the residue for further decocting and filtering, and the filtrates are combined, to obtain the Chinese medicine preparation, wherein the decocting comprises boiling with a strong fire and decocting with a weak fire for 1.5 h.

[0065] Experimental Example

[0066] 87 patients were clinically diagnosed as chronic pancreatitis, 58 males and 19 females, aged 26-63 years, with a disease course of 0.5-2 years; the patients had at least 3 of the following clinical symptoms: abdominal pain, abdominal distension, nausea and vomiting, fever, and abdominal muscle tension;

[0067] Treatment method:

[0068] 43 cases were treated with the traditional Chinese medicine preparation of Example 5, 21 cases were treated with the traditional Chinese medicine preparation of Comparative Example 1, and 23 cases were treated with the traditional Chinese medicine preparation of Comparative Example 2;

[0069] Treatment method: 200ml each time, twice a day, for 1 month;

[0070] Efficacy evaluation:

[0071] Marked effect: all clinical symptoms disappeared;

[0072] Effective: at least one clinical symptom was relieved;

[0073] Ineffective: no change or aggravation of clinical symptoms.

[0074] The results are shown in Table 1:

[0075] Table 1

[0076] Group excellent (human) effective (human) ineffective (human) Example 5 23 18 2 Comparative Example 1 3 12 6 Comparative Example 2 1 13 9

[0077] From Table 1, it can be seen that:

[0078] Compared with the comparative examples, the traditional Chinese medicine preparation prepared by the application can better relieve the symptoms of chronic pancreatitis and has better therapeutic effect on pancreatitis.

[0079] Finally, it should be noted that: the above examples are only used to illustrate the technical solutions of the application, but not to limit them; although the application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing examples, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the application, and they should be covered in the scope of the claims and the specification of the application.

Claims

1. A traditional Chinese medicine preparation for treating chronic pancreatitis, characterized in that, The Chinese medicinal preparation is prepared from the following components in parts by weight: Dangshen 5-15 parts, Baijiangcao 10-20 parts, Chaihu 5-15 parts, Huamao 4-8 parts, Huangqi 5-15 parts, Wulingzhi 5-15 parts, Zhishi 5-15 parts, Chuanlianzi 5-10 parts, Fuling 10-20 parts, Hujiang 4-6 parts, Baishao 10-20 parts, E'zhu 10-20 parts, Gancao 4-8 parts, Tianmendong 10-15 parts, Dahuang 4-8 parts and Baizhu 10-15 parts.

2. The traditional Chinese medicine preparation according to claim 1, characterized in that, The Chinese medicinal preparation is prepared from the following components in parts by weight: Dangshen 8-12 parts, Baijiangcao 12-18 parts, Chaihu 8-12 parts, Huamao 5-7 parts, Huangqi 8-12 parts, Wulingzhi 8-12 parts, Zhishi 8-12 parts, Chuanlianzi 6-8 parts, Fuling 12-18 parts, Hujiang 5-6 parts, Baishao 12-18 parts, E'zhu 12-18 parts, Gancao 5-7 parts, Tianmendong 12-13 parts, Dahuang 5-7 parts and Baizhu 12-13 parts.

3. The traditional Chinese medicine preparation according to claim 1, characterized in that, The Chinese medicinal preparation is prepared from the following components in parts by weight: Dangshen 10 parts, Baijiangcao 15 parts, Chaihu 10 parts, Huamao 6 parts, Huangqi 10 parts, Wulingzhi 10 parts, Zhishi 10 parts, Chuanlianzi 7 parts, Fuling 15 parts, Hujiang 6 parts, Baishao 15 parts, E'zhu 15 parts, Gancao 6 parts, Tianmendong 12 parts, Dahuang 6 parts and Baizhu 12 parts.

4. The preparation method of the traditional Chinese medicine preparation according to any one of claims 1-3, characterized in that, The preparation method comprises the following steps: (a) weighing each Chinese medicinal component according to parts by weight; (b) adding each Chinese medicinal component into water to perform decocting, filtering, adding water into the filter residue to continue decocting, filtering, and combining the filtrates to obtain the Chinese medicinal preparation.

5. The production method according to claim 4, characterized by, The decocting comprises boiling with strong fire and decocting with weak fire for 1-2 hours.

6. The preparation method according to claim 4, characterized in that, The mass ratio of the Chinese medicinal component to water is 1:(6-10).

7. The preparation method according to claim 4, characterized in that, The amount of water added into the filter residue is 5-8 times of the mass of the Chinese medicinal component.